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Aliases for INHBA Gene

Aliases for INHBA Gene

  • Inhibin Beta A 2 3 5
  • Inhibin, Beta A (Activin A, Activin AB Alpha Polypeptide) 2 3
  • Erythroid Differentiation Protein 3 4
  • Activin Beta-A Chain 3 4
  • EDF 3 4
  • Follicle-Stimulating Hormone-Releasing Protein 3
  • Erythroid Differentiation Factor 3
  • FSH-Releasing Protein 3
  • Inhibin, Beta A 2
  • Inhibin, Beta-1 3
  • FRP 3

External Ids for INHBA Gene

Previous GeneCards Identifiers for INHBA Gene

  • GC07M041375
  • GC07M041469
  • GC07M041502
  • GC07M041695
  • GC07M041724

Summaries for INHBA Gene

Entrez Gene Summary for INHBA Gene

  • The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for INHBA Gene

INHBA (Inhibin Beta A) is a Protein Coding gene. Diseases associated with INHBA include ovary adenocarcinoma and preterm premature rupture of the membranes. Among its related pathways are Signaling by GPCR and Transport to the Golgi and subsequent modification. GO annotations related to this gene include identical protein binding and receptor binding. An important paralog of this gene is INHBB.

UniProtKB/Swiss-Prot for INHBA Gene

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Gene Wiki entry for INHBA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INHBA Gene

Genomics for INHBA Gene

Regulatory Elements for INHBA Gene

Genomic Location for INHBA Gene

Chromosome:
7
Start:
41,685,114 bp from pter
End:
41,703,108 bp from pter
Size:
17,995 bases
Orientation:
Minus strand

Genomic View for INHBA Gene

Genes around INHBA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INHBA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INHBA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INHBA Gene

Proteins for INHBA Gene

  • Protein details for INHBA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08476-INHBA_HUMAN
    Recommended name:
    Inhibin beta A chain
    Protein Accession:
    P08476
    Secondary Accessions:
    • Q14599

    Protein attributes for INHBA Gene

    Size:
    426 amino acids
    Molecular mass:
    47442 Da
    Quaternary structure:
    • Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.

    Three dimensional structures from OCA and Proteopedia for INHBA Gene

neXtProt entry for INHBA Gene

Proteomics data for INHBA Gene at MOPED

Post-translational modifications for INHBA Gene

  • Glycosylation at Asn 165
  • Modification sites at PhosphoSitePlus

Other Protein References for INHBA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for INHBA Gene

Domains & Families for INHBA Gene

Gene Families for INHBA Gene

Graphical View of Domain Structure for InterPro Entry

P08476

UniProtKB/Swiss-Prot:

INHBA_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with INHBA: view

Function for INHBA Gene

Molecular function for INHBA Gene

GENATLAS Biochemistry:
inhibin,beta A subunit,14kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,homodimerizing to form activing A stimulator of FSH secretion and involved in embryonic axis development or heterodimerizing with INHBB or INHA to form activin AB or inhibitin A,respectively
UniProtKB/Swiss-Prot Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

LifeMap Function Summary for INHBA Gene

INHBA as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for INHBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005160 transforming growth factor beta receptor binding IBA --
genes like me logo Genes that share ontologies with INHBA: view
genes like me logo Genes that share phenotypes with INHBA: view

Animal Models for INHBA Gene

MGI Knock Outs for INHBA:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INHBA Gene

Localization for INHBA Gene

Subcellular locations from UniProtKB/Swiss-Prot for INHBA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INHBA Gene COMPARTMENTS Subcellular localization image for INHBA gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
mitochondrion 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for INHBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043512 inhibin A complex IDA 7890768
genes like me logo Genes that share ontologies with INHBA: view

Pathways & Interactions for INHBA Gene

genes like me logo Genes that share pathways with INHBA: view

Gene Ontology (GO) - Biological Process for INHBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 9884026
GO:0001707 mesoderm formation IEA --
GO:0001942 hair follicle development IGI 10932194
GO:0002244 hematopoietic progenitor cell differentiation IDA 15451575
GO:0006952 defense response TAS 12456957
genes like me logo Genes that share ontologies with INHBA: view

No data available for SIGNOR curated interactions for INHBA Gene

Drugs & Compounds for INHBA Gene

(4) Drugs for INHBA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for INHBA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INHBA: view

Transcripts for INHBA Gene

mRNA/cDNA for INHBA Gene

Unigene Clusters for INHBA Gene

Inhibin, beta A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INHBA Gene

No ASD Table

Relevant External Links for INHBA Gene

GeneLoc Exon Structure for
INHBA
ECgene alternative splicing isoforms for
INHBA

Expression for INHBA Gene

mRNA expression in normal human tissues for INHBA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INHBA Gene

This gene is overexpressed in Artery - Tibial (x6.8), Artery - Coronary (x6.4), and Artery - Aorta (x4.9).

Protein differential expression in normal tissues from HIPED for INHBA Gene

This gene is overexpressed in Amniocyte (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for INHBA Gene



SOURCE GeneReport for Unigene cluster for INHBA Gene Hs.583348

genes like me logo Genes that share expression patterns with INHBA: view

Protein tissue co-expression partners for INHBA Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for INHBA Gene

Orthologs for INHBA Gene

This gene was present in the common ancestor of animals.

Orthologs for INHBA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia INHBA 35
  • 91.69 (n)
  • 96.47 (a)
INHBA 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INHBA 35
  • 89.86 (n)
  • 92.22 (a)
INHBA 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inhba 35
  • 89.78 (n)
  • 94.58 (a)
Inhba 16
Inhba 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia INHBA 35
  • 99.61 (n)
  • 100 (a)
INHBA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inhba 35
  • 90.09 (n)
  • 94.58 (a)
oppossum
(Monodelphis domestica)
Mammalia INHBA 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INHBA 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves INHBA 35
  • 80.27 (n)
  • 84.43 (a)
INHBA 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INHBA 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia inhba 35
  • 69.91 (n)
  • 71.29 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
inhbab 35
  • 63.74 (n)
  • 63.31 (a)
inhbaa 36
  • 57 (a)
OneToMany
inhbab 36
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Actbeta 35
  • 46.98 (n)
  • 35.91 (a)
Actbeta 36
  • 13 (a)
OneToMany
Species with no ortholog for INHBA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INHBA Gene

ENSEMBL:
Gene Tree for INHBA (if available)
TreeFam:
Gene Tree for INHBA (if available)

Paralogs for INHBA Gene

Paralogs for INHBA Gene

(2) SIMAP similar genes for INHBA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INHBA: view

Variants for INHBA Gene

Sequence variations from dbSNP and Humsavar for INHBA Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs41294833 - 41,690,035(-) CCGGC(A/C)GTCTG reference, missense
VAR_072640 -
VAR_072641 -
rs2237435 -- 41,691,455(-) GCCAC(G/T)TTCTG intron-variant
rs2237436 -- 41,691,333(-) AGGAG(C/G)CCTTC intron-variant

Variation tolerance for INHBA Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INHBA Gene

HapMap Linkage Disequilibrium report
INHBA
Human Gene Mutation Database (HGMD)
INHBA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for INHBA Gene

Disorders for INHBA Gene

MalaCards: The human disease database

(2) MalaCards diseases for INHBA Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
ovary adenocarcinoma
  • adenocarcinoma of the ovary
preterm premature rupture of the membranes
  • preterm premature rupture of the membranes, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search INHBA in MalaCards View complete list of genes associated with diseases

Relevant External Links for INHBA

Genetic Association Database (GAD)
INHBA
Human Genome Epidemiology (HuGE) Navigator
INHBA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INHBA
genes like me logo Genes that share disorders with INHBA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INHBA Gene

Publications for INHBA Gene

  1. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PMID: 18413775) Purdue M.P. … McGlynn K.A. (Cancer Res. 2008) 3 23 48 67
  2. INHBA overexpression promotes cell proliferation and may be epigenetically regulated in esophageal adenocarcinoma. (PMID: 19240652) Seder C.W. … Beer D.G. (J Thorac Oncol 2009) 3 23
  3. Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma. (PMID: 19308293) Seder C.W. … Beer D.G. (Neoplasia 2009) 3 23
  4. Activin A enhances MMP-7 activity via the transcription factor AP-1 in an esophageal squamous cell carcinoma cell line. (PMID: 18695873) Yoshinaga K. … Mori M. (Int. J. Oncol. 2008) 3 23
  5. Activin a causes cancer cell aggressiveness in esophageal squamous cell carcinoma cells. (PMID: 17909904) Yoshinaga K. … Mori M. (Ann. Surg. Oncol. 2008) 3 23

Products for INHBA Gene

Sources for INHBA Gene

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