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Aliases for INHBA Gene

Aliases for INHBA Gene

  • Inhibin, Beta A 2 3
  • Inhibin, Beta A (Activin A, Activin AB Alpha Polypeptide) 2 3
  • Erythroid Differentiation Protein 3 4
  • Activin Beta-A Chain 3 4
  • EDF 3 4
  • Follicle-Stimulating Hormone-Releasing Protein 3
  • Erythroid Differentiation Factor 3
  • FSH-Releasing Protein 3
  • Inhibin Beta A Chain 3
  • Inhibin, Beta-1 3
  • FRP 3

External Ids for INHBA Gene

Summaries for INHBA Gene

Entrez Gene Summary for INHBA Gene

  • The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for INHBA Gene

INHBA (Inhibin, Beta A) is a Protein Coding gene. Diseases associated with INHBA include ovary adenocarcinoma and preterm premature rupture of the membranes. Among its related pathways are Signaling by GPCR and Cardiac Progenitor Differentiation. GO annotations related to this gene include identical protein binding and cytokine activity. An important paralog of this gene is INHBB.

UniProtKB/Swiss-Prot for INHBA Gene

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins

Gene Wiki entry for INHBA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INHBA Gene

Genomics for INHBA Gene

Genomic Location for INHBA Gene

Start:
41,685,114 bp from pter
End:
41,703,108 bp from pter
Size:
17,995 bases
Orientation:
Minus strand

Genomic View for INHBA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INHBA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INHBA Gene

Regulatory Elements for INHBA Gene

Proteins for INHBA Gene

  • Protein details for INHBA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08476-INHBA_HUMAN
    Recommended name:
    Inhibin beta A chain
    Protein Accession:
    P08476
    Secondary Accessions:
    • Q14599

    Protein attributes for INHBA Gene

    Size:
    426 amino acids
    Molecular mass:
    47442 Da
    Quaternary structure:
    • Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.

    Three dimensional structures from OCA and Proteopedia for INHBA Gene

neXtProt entry for INHBA Gene

Proteomics data for INHBA Gene at MOPED

Post-translational modifications for INHBA Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn165

Other Protein References for INHBA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for INHBA Gene

Domains for INHBA Gene

Gene Families for INHBA Gene

HGNC:

UniProtKB/Swiss-Prot:

INHBA_HUMAN
Family:
  • Belongs to the TGF-beta family.:
    • P08476
genes like me logo Genes that share domains with INHBA: view

Function for INHBA Gene

Molecular function for INHBA Gene

GENATLAS Biochemistry: inhibin,beta A subunit,14kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,homodimerizing to form activing A stimulator of FSH secretion and involved in embryonic axis development or heterodimerizing with INHBB or INHA to form activin AB or inhibitin A,respectively
UniProtKB/Swiss-Prot Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins

LifeMap Function Summary for INHBA Gene

INHBA as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for INHBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005125 cytokine activity IDA 9884026
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0005179 hormone activity TAS 12456957
GO:0005515 protein binding IPI 12697670
genes like me logo Genes that share ontologies with INHBA: view
genes like me logo Genes that share phenotypes with INHBA: view

Animal Models for INHBA Gene

MGI Knock Outs for INHBA:

miRNA for INHBA Gene

miRTarBase miRNAs that target INHBA

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for INHBA Gene

Localization for INHBA Gene

Subcellular locations from UniProtKB/Swiss-Prot for INHBA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INHBA Gene COMPARTMENTS Subcellular localization image for INHBA gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
mitochondrion 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for INHBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0043509 activin A complex IDA 7890768
GO:0043512 inhibin A complex IDA 7890768
genes like me logo Genes that share ontologies with INHBA: view

Pathways for INHBA Gene

genes like me logo Genes that share pathways with INHBA: view

Gene Ontology (GO) - Biological Process for INHBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 9884026
GO:0001541 ovarian follicle development NAS 9166111
GO:0001707 mesoderm formation --
GO:0001942 hair follicle development IGI 10932194
GO:0002244 hematopoietic progenitor cell differentiation IDA 15451575
genes like me logo Genes that share ontologies with INHBA: view

Compounds for INHBA Gene

(7) Novoseek inferred chemical compound relationships for INHBA Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 29 3
oligonucleotide 22.7 5
progesterone 12.4 1
testosterone 9.39 1
cycloheximide 2.59 1
genes like me logo Genes that share compounds with INHBA: view

Transcripts for INHBA Gene

mRNA/cDNA for INHBA Gene

Unigene Clusters for INHBA Gene

Inhibin, beta A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INHBA Gene

No ASD Table

Relevant External Links for INHBA Gene

GeneLoc Exon Structure for
INHBA
ECgene alternative splicing isoforms for
INHBA

Expression for INHBA Gene

mRNA expression in normal human tissues for INHBA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INHBA Gene

This gene is overexpressed in Artery - Tibial (6.8), Artery - Coronary (6.4), and Artery - Aorta (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INHBA Gene

SOURCE GeneReport for Unigene cluster for INHBA Gene Hs.583348

genes like me logo Genes that share expressions with INHBA: view

Orthologs for INHBA Gene

This gene was present in the common ancestor of animals.

Orthologs for INHBA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INHBA 36
  • 99.61 (n)
  • 100 (a)
INHBA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INHBA 36
  • 91.69 (n)
  • 96.47 (a)
INHBA 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INHBA 36
  • 89.86 (n)
  • 92.22 (a)
INHBA 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inhba 36
  • 89.78 (n)
  • 94.58 (a)
Inhba 16
Inhba 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INHBA 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INHBA 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inhba 36
  • 90.09 (n)
  • 94.58 (a)
chicken
(Gallus gallus)
Aves INHBA 36
  • 80.27 (n)
  • 84.43 (a)
INHBA 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INHBA 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia inhba 36
  • 69.91 (n)
  • 71.29 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
inhbaa 37
  • 57 (a)
OneToMany
inhbab 36
  • 63.74 (n)
  • 63.31 (a)
inhbab 37
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Actbeta 36
  • 46.98 (n)
  • 35.91 (a)
Actbeta 37
  • 13 (a)
OneToMany
Species with no ortholog for INHBA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INHBA Gene

ENSEMBL:
Gene Tree for INHBA (if available)
TreeFam:
Gene Tree for INHBA (if available)

Paralogs for INHBA Gene

Paralogs for INHBA Gene

Selected SIMAP similar genes for INHBA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INHBA: view

Variants for INHBA Gene

Sequence variations from dbSNP and Humsavar for INHBA Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1139448 -- 41,689,476(-) CAGAT(A/G)AAACA utr-variant-3-prime
rs2237435 -- 41,691,455(-) GCCAC(G/T)TTCTG intron-variant
rs2237436 -- 41,691,333(-) AGGAG(C/G)CCTTC intron-variant
rs6961410 -- 41,688,552(+) ataat(A/T)ataat downstream-variant-500B
rs34617847 -- 41,690,391(+) GGTGC(-/G)TTCTG reference, frameshift-variant

Relevant External Links for INHBA Gene

HapMap Linkage Disequilibrium report
INHBA
Human Gene Mutation Database (HGMD)
INHBA

No data available for Structural Variations from Database of Genomic Variants (DGV) for INHBA Gene

Disorders for INHBA Gene

(14) Novoseek inferred disease relationships for INHBA Gene

Disease -log(P) Hits PubMed IDs
sex cord-stromal tumor 56.7 3
erythroleukemia 46.2 3
esophageal carcinoma 40.4 4
epithelial tumor 20.8 1
tumors 19.8 13

Relevant External Links for INHBA

Genetic Association Database (GAD)
INHBA
Human Genome Epidemiology (HuGE) Navigator
INHBA
genes like me logo Genes that share disorders with INHBA: view

No data available for UniProtKB/Swiss-Prot for INHBA Gene

Publications for INHBA Gene

  1. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PMID: 18413775) Purdue M.P. … McGlynn K.A. (Cancer Res. 2008) 3 23 49
  2. Activin A enhances MMP-7 activity via the transcription factor AP-1 in an esophageal squamous cell carcinoma cell line. (PMID: 18695873) Yoshinaga K. … Mori M. (Int. J. Oncol. 2008) 3 23
  3. The distribution of activin and activin receptors in gestational tissues across human pregnancy and during labour. (PMID: 11969340) Schneider-Kolsky M.E. … Wallace E.M. (Placenta 2002) 3 23
  4. Activin a causes cancer cell aggressiveness in esophageal squamous cell carcinoma cells. (PMID: 17909904) Yoshinaga K. … Mori M. (Ann. Surg. Oncol. 2008) 3 23
  5. Inhibin/activin betaB-subunit expression in pheochromocytomas favors benign diagnosis. (PMID: 11344232) Salmenkivi K. … Liu J. (J. Clin. Endocrinol. Metab. 2001) 3 23

Products for INHBA Gene

Sources for INHBA Gene

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