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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INHBA Gene

protein-coding   GIFtS: 64
GCID: GC07M041724

Inhibin, Beta A

(Previous names: inhibin, beta A (activin A, activin AB alpha polypeptide))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Inhibin, Beta A1 2     Erythroid Differentiation Factor2
Inhibin, Beta A (Activin A, Activin AB Alpha Polypeptide)1 2     Follicle-Stimulating Hormone-Releasing Protein2
Activin Beta-A Chain2 3     FSH-Releasing Protein2
Erythroid Differentiation Protein2 3     Inhibin Beta A Chain2
EDF2 3     Inhibin, Beta-12
FRP2     

External Ids:    HGNC: 60661   Entrez Gene: 36242   Ensembl: ENSG000001226417   OMIM: 1472905   UniProtKB: P084763   

Export aliases for INHBA gene to outside databases

Previous GC identifers: GC07M041375 GC07M041469 GC07M041502 GC07M041695


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INHBA Gene:
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been
shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In
addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore
be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various
extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a
growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and
also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor
subunit mRNA and that only one gene for this mRNA exists in the human genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for INHBA Gene: 
INHBA (inhibin, beta A) is a protein-coding gene. Diseases associated with INHBA include ectopic pregnancy, and ovarian clear cell adenocarcinoma, and among its related super-pathways are Signaling by Activin and Signaling by GPCR. GO annotations related to this gene include growth factor activity and protein heterodimerization activity. An important paralog of this gene is GDF11.

UniProtKB/Swiss-Prot: INHBA_HUMAN, P08476
Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and
pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid
differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on
their subunit composition. Inhibins appear to oppose the functions of activins

Gene Wiki entry for INHBA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INHBA gene promoter:
         Sox5   Pax-5   IRF-1   Ik-3   NF-kappaB   Arnt   AREB6   FOXC1   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): INHBA promoter sequence
   Search SABiosciences Chromatin IP Primers for INHBA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INHBA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15-p13   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p15-p13

INHBA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INHBA gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M041724:  view genomic region     (about GC identifiers)

Start:
41,724,712 bp from pter      End:
41,742,706 bp from pter
Size:
17,995 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 41,768,467-41,782,571     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INHBA_HUMAN, P08476 (See protein sequence)
Recommended Name: Inhibin beta A chain precursor  
Size: 426 amino acids; 47442 Da
Subunit: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a
dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is
a dimer of beta-A and beta-B. Interacts with FST and FSTL3
Subcellular location: Secreted
6/8 PDB 3D structures from and Proteopedia for INHBA (see all 8):
1NYS (3D)        1NYU (3D)        1S4Y (3D)        2ARP (3D)        2ARV (3D)        2B0U (3D)    
Secondary accessions: Q14599

Explore the universe of human proteins at neXtProt for INHBA: NX_P08476

Explore proteomics data for INHBA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08476

  • INHBA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INHBA Protein Expression
    REFSEQ proteins: NP_002183.1  
    ENSEMBL proteins: 
     ENSP00000242208   ENSP00000397197  
    Reactome Protein details: P08476
    Human Recombinant Protein Products for INHBA: 
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    Novus Biologicals INHBA Proteins
    Novus Biologicals INHBA Lysates
    Sino Biological Recombinant Protein for INHBA
    Sino Biological Cell Lysate for INHBA 
    ProSpec Recombinant Protein for INHBA
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0043509activin A complex IDA7890768
    GO:0043512inhibin A complex IDA7890768

    INHBA for ontologies           About GeneDecksing



    INHBA Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR000491 Inhibin_betaA
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P08476

    ProtoNet protein and cluster: P08476

    4 Blocks protein domains:
    IPB000491 Inhibin beta A chain signature
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: INHBA_HUMAN, P08476
    Similarity: Belongs to the TGF-beta family


    INHBA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INHBA_HUMAN, P08476
    Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
    gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and
    pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid
    differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on
    their subunit composition. Inhibins appear to oppose the functions of activins

         Genatlas biochemistry entry for INHBA:
    inhibin,beta A subunit,14kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,homodimerizing to form
    activing A stimulator of FSH secretion and involved in embryonic axis development or heterodimerizing with INHBB
    or INHA to form activin AB or inhibitin A,respectively

         Summary:
    INHBA as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: BMP4-induced embryoid bodies from Mesoderm, Definitive endoderm-like cells from Endoderm (see all).

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005125cytokine activity IDA9884026
    GO:0005179hormone activity TAS12456957
    GO:0005515protein binding IPI12697670
    GO:0008083growth factor activity TAS12324653
         
    INHBA for ontologies           About GeneDecksing


    Phenotypes:
         15/16 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Inhba) (see all 16):
     behavior/neurological  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  integument  mortality/aging 
     muscle  normal  renal/urinary system  reproductive system  skeleton 

    INHBA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Inhbatm1Zuk for INHBA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for INHBA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INHBA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INHBA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INHBA 

    miRNA
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    hsa-miR-1233 hsa-miR-135b hsa-miR-205 hsa-miR-452* hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidINHBA 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for INHBA About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by NODAL
    Signaling by Activin0.36
    Antagonism of Activin by Follistatin0.33
    2Signaling by GPCR
    Signal Transduction0.55
    3PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    4PKA activation in glucagon signalling
    Development Role of Activin A in cell differentiation and proliferation0.33
    5Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for INHBA
        Development Role of Activin A in cell differentiation and proliferation
    Signal transduction Activin A signaling regulation


    2 GeneGo (Thomson Reuters) Pathways for INHBA
        Signal transduction Activin A signaling regulation
    Development Role of Activin A in cell differentiation and proliferation

    5 BioSystems Pathways for INHBA
        TGF Beta Signaling Pathway
    Senescence and Autophagy
    Cardiac Progenitor Differentiation
    Integrated Pancreatic Cancer Pathway
    ALK1 signaling events

    1 Sino Biological Pathway for INHBA 
        TGF-beta Signaling Pathway

    3        Reactome Pathways for INHBA
        Signaling by Activin
    Signal Transduction
    Antagonism of Activin by Follistatin


    2         Kegg Pathways  (Kegg details for INHBA):
        Cytokine-cytokine receptor interaction
    TGF-beta signaling pathway


    INHBA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INHBA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/26 Interacting proteins for INHBA (P084762, 3 ENSP000002422084) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR2BQ137053, ENSP000003403614I2D: score=4 STRING: ENSP00000340361
    ACVR1BP368963, ENSP000002579634I2D: score=2 STRING: ENSP00000257963
    CHRDL2Q6WN343, ENSP000002636714I2D: score=2 STRING: ENSP00000263671
    FSTP198833, ENSP000002567594I2D: score=2 STRING: ENSP00000256759
    ACVR1Q047713, ENSP000002636404I2D: score=1 STRING: ENSP00000263640
    About this table

    Gene Ontology (GO): 5/42 biological process terms (GO ID links to tree view) (see all 42):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IDA9884026
    GO:0001541ovarian follicle development NAS9166111
    GO:0001707mesoderm formation ----
    GO:0001942hair follicle development IGI10932194
    GO:0002244hematopoietic progenitor cell differentiation IDA15451575

    INHBA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INHBA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INHBA

    7 Novoseek inferred chemical compound relationships for INHBA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 29 5 19308293 (2), 19240652 (1)
    oligonucleotide 22.7 5 19240652 (2), 10810314 (1), 19308293 (1), 1863557 (1)
    progesterone 12.4 1 10965925 (1)
    testosterone 9.39 1 1750706 (1)
    cycloheximide 2.59 1 10906757 (1)
    forskolin 1.38 2 12538609 (1)
    estrogen 0 2 7536182 (1)

    Search CenterWatch for drugs/clinical trials and news about INHBA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INHBA gene: 
    NM_002192.2  

    Unigene Cluster for INHBA:

    Inhibin, beta A
    Hs.583348  [show with all ESTs]
    Unigene Representative Sequence: BX648811
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000242208(uc003thq.3 uc003thr.3) ENST00000464515 ENST00000442711


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    hsa-miR-1233 hsa-miR-135b hsa-miR-205 hsa-miR-452* hsa-miR-135a
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    Additional mRNA sequence: 

    AF218018.1 AK222742.1 AK290584.1 BC007858.2 BX648811.1 D49743.1 J03634.1 M13436.1 
    X72498.1 

    9 DOTS entries:

    DT.91741308  DT.452433  DT.92030578  DT.92008315  DT.99942006  DT.100707716  DT.102831894  DT.40316631 
    DT.95173216 

    24/110 AceView cDNA sequences (see all 110):

    AI738775 CD367517 CD366041 BC007858 AI753619 BQ267396 BQ574581 BP341643 
    BM554468 BQ006749 BF439415 AL599843 T29604 AI905388 CN480753 BF000451 
    BM555692 CK825381 CA310336 BQ003646 AU139087 AA948385 CF594232 BM423883 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INHBA expression in normal human tissues (normalized intensities)      INHBA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCGTGGAGG
    INHBA Expression
    About this image


    INHBA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/42 selected tissues (see all 42) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Septum   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             Intervertebral Disc Annulus Fibrosus Cells Lumbar Intervertebral Disc
             fetal cartilage   
     
     Testis (Reproductive System)    fully expand to see all 6 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Tooth
             Dental Mesenchymal Cells Branchial Arch 1
             visceral organ/oral region/upper jaw   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
             lung ; macrophages   

    See INHBA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INHBA

    SOURCE GeneReport for Unigene cluster: Hs.583348
        SABiosciences Expression via Pathway-Focused PCR Arrays including INHBA (see all 8): 
              Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Common Cytokines in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INHBA gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inhba1 , 5 inhibin beta-A1, 5 90.88(n)1
    96.46(a)1
      13 (5.85 cM)5
    163231  NM_008380.11  NP_032406.11 
     160144755 
    chicken
    (Gallus gallus)
    Aves INHBA1 inhibin, beta A 80.35(n)
    84.43(a)
      396361  NM_205396.1  NP_990727.1 
    lizard
    (Anolis carolinensis)
    Reptilia INHBA6
    Uncharacterized protein
    82(a)
    1 ↔ 1
    6(49715246-49731227)
    zebrafish
    (Danio rerio)
    Actinopterygii AF475092.12   -- 75.89(n)   30072  AF475092.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Actbeta1 Activin-beta 46.42(n)
    35.57(a)
      43826  NM_143685.2  NP_651942.2 


    ENSEMBL Gene Tree for INHBA (if available)
    TreeFam Gene Tree for INHBA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INHBA gene
    GDF112  MSTN2  INHBE2  TGFB22  INHBB2  TGFB32  INHBC2  TGFB12  
    2 SIMAP similar genes for INHBA using alignment to 2 protein entries:     INHBA_HUMAN (see all proteins):
    DKFZp686A06204    INHBB

    INHBA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/96 SNPs in INHBA are shown (see all 96)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456635061,2
    --41728140(+) AATAAC/TAATTA 1 -- ds50010--------
    rs1506823431,2
    --41728251(+) GAAAAC/TACTTG 1 -- ds50010--------
    rs1512003701,2
    C--41728310(+) CGATT-/AAAAAA 1 -- ds50010--------
    rs1151240681,2
    C,F--41728654(+) ACACGA/CTTGTT 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs1391040181,2
    C--41728701(+) ATGCC-/TGTGTG
            
    TGTGT
    1 -- cds10--------
    rs1399239801,2
    C--41728811(+) CCTGTC/GATGGG 1 -- ut310--------
    rs1825513481,2
    --41728877(+) CTGCAA/GACTAG 1 -- ut310--------
    rs1871233041,2
    --41728937(+) TACCCC/TGTTTA 1 -- ut310--------
    rs1919808351,2
    --41729022(+) TCTCTC/TTCACT 1 -- ut310--------
    rs1513042581,2
    C--41729111(+) TTTTG-/TTTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for INHBA (41724712 - 41742706 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for INHBA: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing INHBA
    DNA2.0 Custom Variant and Variant Library Synthesis for INHBA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147290    OMIM disorders: --

    20/66 diseases for INHBA (see all 66):    About MalaCards
    ectopic pregnancy    ovarian clear cell adenocarcinoma    clear cell adenocarcinoma    intrauterine infections
    preterm premature rupture of the membranes    dental caries    klinefelter's syndrome    goiter
    endometrial adenocarcinoma    folliculitis    pheochromocytoma    premature ovarian failure
    pancreatic ductal adenocarcinoma    pre-eclampsia    rheumatic disease    eclampsia
    esophagitis    germ cell tumors    seminoma    endometrial carcinoma


    INHBA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/14 Novoseek inferred disease relationships for INHBA gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sex cord-stromal tumor 56.7 4 10747314 (3)
    erythroleukemia 46.2 3 1542647 (1), 1402687 (1), 2323849 (1)
    esophageal carcinoma 40.4 6 15355896 (1), 18695873 (1), 12469187 (1), 17909904 (1)
    epithelial tumor 20.8 1 10747314 (1)
    tumors 19.8 18 10747314 (3), 17609433 (2), 12206515 (2), 7829603 (1) (see all 9)
    pheochromocytoma 19.8 5 10810314 (3), 11344232 (1), 17680997 (1)
    adenoma 14.7 5 9691207 (1), 7599706 (1), 12821114 (1)
    goiter 14.6 2 11069203 (1), 12729472 (1)
    endometrial carcinoma 13.8 1 11585411 (1)
    carcinoma 11.5 4 19308293 (1), 9570994 (1), 17909904 (1), 12729472 (1)

    Genetic Association Database (GAD): INHBA
    Human Genome Epidemiology (HuGE) Navigator: INHBA (15 documents)

    Export disorders for INHBA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INHBA gene, integrated from 9 sources (see all 281):
    (articles sorted by number of sources associating them with INHBA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PubMed id 18413775)1, 4, 9 Purdue M.P....McGlynn K.A. (2008)
    2. Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    6. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    7. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolis m and breast cancer risk in the NCI breast and prostate cancer cohort consortiu m. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (2010)
    8. Genome-wide association study for colorectal cancer i dentifies risk polymorphisms in German familial cases and implicates MAPK signa lling pathways in disease susceptibility. (PubMed id 20610541)1, 4 Lascorz J....Hemminki K. (2010)
    9. Family-based analysis of candidate genes for polycyst ic ovary syndrome. (PubMed id 20200332)1, 4 Ewens K.G....Spielman R.S. (2010)
    10. Quantitative trait loci predicting circulating sex st eroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3). (PubMed id 19574343)1, 4 Ahn J....Hayes R.B. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3624 HGNC: 6066 AceView: INHBA Ensembl:ENSG00000122641 euGenes: HUgn3624
    ECgene: INHBA Kegg: 3624 H-InvDB: INHBA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INHBA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for INHBA Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Activin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INHBA gene:
    Search GeneIP for patents involving INHBA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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