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Aliases for INHBA Gene

Aliases for INHBA Gene

  • Inhibin Beta A Subunit 2 3 5
  • Inhibin, Beta A (Activin A, Activin AB Alpha Polypeptide) 2 3
  • Erythroid Differentiation Protein 3 4
  • Activin Beta-A Chain 3 4
  • EDF 3 4
  • Follicle-Stimulating Hormone-Releasing Protein 3
  • Erythroid Differentiation Factor 3
  • FSH-Releasing Protein 3
  • Inhibin Beta A Chain 3
  • Inhibin, Beta A 2
  • Inhibin, Beta-1 3
  • Inhibin Beta A 2
  • FRP 3

External Ids for INHBA Gene

Previous GeneCards Identifiers for INHBA Gene

  • GC07M041375
  • GC07M041469
  • GC07M041502
  • GC07M041695
  • GC07M041724
  • GC07M041686

Summaries for INHBA Gene

Entrez Gene Summary for INHBA Gene

  • This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]

GeneCards Summary for INHBA Gene

INHBA (Inhibin Beta A Subunit) is a Protein Coding gene. Diseases associated with INHBA include Ovary Adenocarcinoma and Preterm Premature Rupture Of The Membranes. Among its related pathways are Signaling by NODAL and Mesodermal Commitment Pathway. GO annotations related to this gene include identical protein binding and receptor binding. An important paralog of this gene is INHBB.

UniProtKB/Swiss-Prot for INHBA Gene

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Gene Wiki entry for INHBA Gene

Additional gene information for INHBA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INHBA Gene

Genomics for INHBA Gene

Regulatory Elements for INHBA Gene

Enhancers for INHBA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H040823 0.9 Ensembl ENCODE dbSUPER 21.1 +879.8 879758 4 HNF4A TEAD3 INHBA ENSG00000227658 LOC105375242
GH07H040807 0.9 Ensembl ENCODE dbSUPER 20.2 +896.5 896507 4 JUND POLR2A INHBA ENSG00000227658 LOC105375242
GH07H041732 1.4 FANTOM5 Ensembl ENCODE 11.8 -26.8 -26844 1 CTCF TBL1XR1 JUN ZSCAN4 BATF RAD21 EED SCRT2 SMC3 ATF7 INHBA INHBA-AS1 GC07P041710 GC07P041910
GH07H041572 1.3 Ensembl ENCODE dbSUPER 11.2 +131.1 131113 4 PKNOX1 ESRRA FOXA2 JUN CTBP1 GATA3 FOSL2 FOS MAFK NFE2L2 INHBA-AS1 INHBA LOC105375247 GC07P041337
GH07H040763 0.7 Ensembl ENCODE 17.7 +941.7 941741 1 CTCF RAD21 INHBA INHBA-AS1 GC07P040768 LOC105375243
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INHBA on UCSC Golden Path with GeneCards custom track

Promoters for INHBA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000211469 434 801 CTCF IRF2 RAD21 HIC1 GATA3 ZBTB48 POLR2A EED PATZ1 SMC3

Genomic Location for INHBA Gene

Chromosome:
7
Start:
41,667,168 bp from pter
End:
41,705,834 bp from pter
Size:
38,667 bases
Orientation:
Minus strand

Genomic View for INHBA Gene

Genes around INHBA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INHBA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INHBA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INHBA Gene

Proteins for INHBA Gene

  • Protein details for INHBA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08476-INHBA_HUMAN
    Recommended name:
    Inhibin beta A chain
    Protein Accession:
    P08476
    Secondary Accessions:
    • Q14599

    Protein attributes for INHBA Gene

    Size:
    426 amino acids
    Molecular mass:
    47442 Da
    Quaternary structure:
    • Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.

    Three dimensional structures from OCA and Proteopedia for INHBA Gene

neXtProt entry for INHBA Gene

Post-translational modifications for INHBA Gene

  • Glycosylation at isoforms=165
  • Modification sites at PhosphoSitePlus

Other Protein References for INHBA Gene

Antibody Products

Protein Products

Assay Products

No data available for DME Specific Peptides for INHBA Gene

Domains & Families for INHBA Gene

Gene Families for INHBA Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

P08476

UniProtKB/Swiss-Prot:

INHBA_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with INHBA: view

Function for INHBA Gene

Molecular function for INHBA Gene

GENATLAS Biochemistry:
inhibin,beta A subunit,14kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,homodimerizing to form activing A stimulator of FSH secretion and involved in embryonic axis development or heterodimerizing with INHBB or INHA to form activin AB or inhibitin A,respectively
UniProtKB/Swiss-Prot Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

LifeMap Function Summary for INHBA Gene

INHBA as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for INHBA Gene

Gene Ontology (GO) - Molecular Function for INHBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005125 cytokine activity IDA 9884026
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0005179 hormone activity TAS 12456957
GO:0005515 protein binding IPI 2575216
genes like me logo Genes that share ontologies with INHBA: view
genes like me logo Genes that share phenotypes with INHBA: view

Animal Models for INHBA Gene

MGI Knock Outs for INHBA:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for INHBA
  • Applied Biological Materials Clones for INHBA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INHBA Gene

Localization for INHBA Gene

Subcellular locations from UniProtKB/Swiss-Prot for INHBA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INHBA gene
Compartment Confidence
extracellular 5
mitochondrion 2
endoplasmic reticulum 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for INHBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0043509 activin A complex IDA 7890768
GO:0043512 inhibin A complex IDA 7890768
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with INHBA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for INHBA Gene

Pathways & Interactions for INHBA Gene

genes like me logo Genes that share pathways with INHBA: view

Gene Ontology (GO) - Biological Process for INHBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 9884026
GO:0001541 ovarian follicle development NAS 9166111
GO:0001707 mesoderm formation IEA --
GO:0001942 hair follicle development IGI 10932194
GO:0002244 hematopoietic progenitor cell differentiation IDA 15451575
genes like me logo Genes that share ontologies with INHBA: view

No data available for SIGNOR curated interactions for INHBA Gene

Drugs & Compounds for INHBA Gene

(4) Drugs for INHBA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for INHBA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INHBA: view

Transcripts for INHBA Gene

Unigene Clusters for INHBA Gene

Inhibin, beta A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for INHBA
  • Applied Biological Materials Clones for INHBA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for INHBA Gene

No ASD Table

Relevant External Links for INHBA Gene

GeneLoc Exon Structure for
INHBA
ECgene alternative splicing isoforms for
INHBA

Expression for INHBA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INHBA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INHBA Gene

This gene is overexpressed in Artery - Tibial (x6.8), Artery - Coronary (x6.4), and Artery - Aorta (x4.9).

Protein differential expression in normal tissues from HIPED for INHBA Gene

This gene is overexpressed in Amniocyte (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INHBA Gene



Protein tissue co-expression partners for INHBA Gene

NURSA nuclear receptor signaling pathways regulating expression of INHBA Gene:

INHBA

SOURCE GeneReport for Unigene cluster for INHBA Gene:

Hs.583348

Evidence on tissue expression from TISSUES for INHBA Gene

  • Eye(4.1)
genes like me logo Genes that share expression patterns with INHBA: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INHBA Gene

Orthologs for INHBA Gene

This gene was present in the common ancestor of animals.

Orthologs for INHBA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INHBA 33 34
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia INHBA 33 34
  • 91.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia INHBA 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inhba 33
  • 90.09 (n)
dog
(Canis familiaris)
Mammalia INHBA 33 34
  • 89.86 (n)
mouse
(Mus musculus)
Mammalia Inhba 33 16 34
  • 89.78 (n)
oppossum
(Monodelphis domestica)
Mammalia INHBA 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves INHBA 33 34
  • 80.27 (n)
lizard
(Anolis carolinensis)
Reptilia INHBA 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia inhba 33
  • 69.91 (n)
zebrafish
(Danio rerio)
Actinopterygii inhbab 33 34
  • 63.74 (n)
inhbaa 34
  • 57 (a)
OneToMany
-- 33
fruit fly
(Drosophila melanogaster)
Insecta Actbeta 33 34
  • 46.98 (n)
Species where no ortholog for INHBA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INHBA Gene

ENSEMBL:
Gene Tree for INHBA (if available)
TreeFam:
Gene Tree for INHBA (if available)

Paralogs for INHBA Gene

Paralogs for INHBA Gene

(2) SIMAP similar genes for INHBA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INHBA: view

Variants for INHBA Gene

Sequence variations from dbSNP and Humsavar for INHBA Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000119442 -- 41,705,435(+) TCTTT(C/T)AAGAG intron-variant, reference, synonymous-codon
rs1000132102 -- 41,695,521(+) CTACA(A/G)TAGAG intron-variant
rs1000367260 -- 41,698,452(+) TGTAA(A/G)TATTT intron-variant
rs1000379176 -- 41,684,826(+) GTTGC(C/T)ACTAC downstream-variant-500B
rs1000424417 -- 41,692,266(+) GGGAA(A/C)AATCT intron-variant, upstream-variant-2KB

Variation tolerance for INHBA Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INHBA Gene

Human Gene Mutation Database (HGMD)
INHBA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INHBA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for INHBA Gene

Disorders for INHBA Gene

MalaCards: The human disease database

(3) MalaCards diseases for INHBA Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ovary adenocarcinoma
  • adenocarcinoma of the ovary
preterm premature rupture of the membranes
  • preterm premature rupture of membranes
myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency
  • cms ie
- elite association - COSMIC cancer census association via MalaCards
Search INHBA in MalaCards View complete list of genes associated with diseases

Relevant External Links for INHBA

Genetic Association Database (GAD)
INHBA
Human Genome Epidemiology (HuGE) Navigator
INHBA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INHBA
genes like me logo Genes that share disorders with INHBA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INHBA Gene

Publications for INHBA Gene

  1. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PMID: 18413775) Purdue MP … McGlynn KA (Cancer research 2008) 3 22 45 60
  2. Germline mutations of inhibins in early-onset ovarian epithelial tumors. (PMID: 24302632) Tournier I … Frebourg T (Human mutation 2014) 3 4 60
  3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 45 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 45 60

Products for INHBA Gene

  • Addgene plasmids for INHBA

Sources for INHBA Gene

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