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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

INHBA Gene

protein-coding GIFtS: 64
GCID: GC07M041724

inhibin, beta A

(Previous names: inhibin, beta A (activin A, activin AB alpha polypeptide)...)

Explore 73 diseases affiliated with
INHBA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Inhibin, Beta A¹ ²		Erythroid Differentiation Factor²
Inhibin, Beta A (Activin A, Activin AB Alpha Polypeptide)¹ ²		Follicle-Stimulating Hormone-Releasing Protein²
Activin Beta-A Chain² ³		FSH-Releasing Protein²
Erythroid Differentiation Protein² ³		Inhibin Beta A Chain²
EDF² ³		Inhibin, Beta-1²
FRP²

External Ids:	HGNC: 6066¹	Entrez Gene: 3624²	Ensembl: ENSG00000122641⁷	OMIM: 147290⁵	UniProtKB: P08476³

Export aliases for INHBA gene to outside databases

Previous GC identifers: GC07M041375 GC07M041469 GC07M041502 GC07M041695

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INHBA:

The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown

to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum

levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker

for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary

severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and

a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form

a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit

mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in

the human genome. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: INHBA_HUMAN, P08476

Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary

gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary

hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin

secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.

Inhibins appear to oppose the functions of activins

Gene Wiki entry for INHBA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the INHBA gene promoter:
Sox5 Pax-5 IRF-1 Ik-3 NF-kappaB Arnt AREB6 FOXC1 NF-kappaB2 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): INHBA promoter sequence

Search SABiosciences Chromatin IP Primers for INHBA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INHBA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15-p13 Ensembl cytogenetic band: 7p14.1 HGNC cytogenetic band: 7p15-p13

INHBA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INHBA gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M041724: view genomic region (about GC identifiers)

Start:	41,724,712 bp from pter	End:	41,742,706 bp from pter
Size:	17,995 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 41,768,467-41,782,571

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: INHBA_HUMAN, P08476 (See protein sequence)

Recommended Name: Inhibin beta A chain precursor

Size: 426 amino acids; 47442 Da

Subunit: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer

of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of

beta-A and beta-B. Interacts with FST and FSTL3

Subcellular location: Secreted

6/8 PDB 3D structures from and Proteopedia for INHBA (see all 8):

1NYS (3D)

1NYU (3D)

1S4Y (3D)

2ARP (3D)

2ARV (3D)

2B0U (3D)

Secondary accessions: Q14599

Explore the universe of human proteins at neXtProt for INHBA: NX_P08476

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08476

INHBA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002183.1

ENSEMBL proteins:

ENSP00000242208 ENSP00000397197

Reactome Protein details: P08476
Human Recombinant Protein Products:

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	Sino Biological Recombinant Protein for INHBA
	ProSpec Recombinant Protein for INHBA
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0043509	activin A complex	IDA	7890768
GO:0043512	inhibin A complex	IDA	7890768

INHBA for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

INHBA for domains About GeneDecksing

5 InterPro domains/families:

IPR001111 TGF-b_N

IPR000491 Inhibin_betaA

IPR015615 TGF-beta-rel

IPR001839 TGF-b_C

IPR017948 TGFb_CS

Graphical View of Domain Structure for InterPro Entry P08476

ProtoNet protein and cluster: P08476

4 Blocks protein families:

IPB000491 Inhibin beta A chain signature

IPB001111 Transforming growth factor beta (TGFb)

IPB001839 Transforming growth factor beta (TGFb)

IPB002400 Growth factor cystine knot superfamily signature

UniProtKB/Swiss-Prot: INHBA_HUMAN, P08476

Similarity: Belongs to the TGF-beta family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: INHBA_HUMAN, P08476

Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary

gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary

hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin

secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.

Inhibins appear to oppose the functions of activins

Genatlas biochemistry entry for INHBA:

inhibin,beta A subunit,14kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,homodimerizing to form activing A

stimulator of FSH secretion and involved in embryonic axis development or heterodimerizing with INHBB or INHA to form

activin AB or inhibitin A,respectively

Summary:

INHBA as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Definitive endoderm-like cells, Endoderm-like cell (see all 40).

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		hsa-miR-1233 hsa-miR-135b hsa-miR-205 hsa-miR-452* hsa-miR-135a
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBA

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	--	--
GO:0005125	cytokine activity	IDA	9884026
GO:0005179	hormone activity	TAS	12456957
GO:0005515	protein binding	IPI	12697670
GO:0008083	growth factor activity	TAS	12324653

INHBA for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Inhba^tm1Zuk for INHBA
     15/16 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Inhba) (see all 16):

behavior/neurological	craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	integument	mortality/aging
muscle	normal	renal/urinary system	reproductive system	skeleton

INHBA for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signal transduction Activin A signaling regulation

Signal transduction Activin A signaling regulation

1.00

Signal transduction_Activin A signaling regulation

0.96

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

Signaling by NODAL

Signaling by Activin

0.36

Antagonism of Activin by Follistatin

0.00

PKA activation in glucagon signalling

Development_Role of Activin A in cell differentiation and proliferation

0.33

Development Role of Activin A in cell differentiation and proliferation

0.33

TGF Beta Signaling Pathway

TGF Beta Signaling Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for INHBA

	Development Role of Activin A in cell differentiation and proliferation
	Signal transduction Activin A signaling regulation

2 GeneGo (Thomson Reuters) Pathways for INHBA

	Signal transduction Activin A signaling regulation
	Development Role of Activin A in cell differentiation and proliferation

5 BioSystems Pathways for INHBA

	Senescence and Autophagy
	TGF Beta Signaling Pathway
	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	ALK1 signaling events

3 Reactome Pathways for INHBA

	Signaling by Activin
	Signal Transduction
	Antagonism of Activin by Follistatin

2 Kegg Pathways (Kegg details for INHBA):

	Cytokine-cytokine receptor interaction
	TGF-beta signaling pathway

INHBA for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for INHBA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/26 Interacting proteins for INHBA (P08476^{2, 3} ENSP00000242208⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 26)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACVR2B	Q13705³, ENSP00000340361⁴	I2D: score=4 STRING: ENSP00000340361
ACVR1B	P36896³, ENSP00000257963⁴	I2D: score=2 STRING: ENSP00000257963
CHRDL2	Q6WN34³, ENSP00000263671⁴	I2D: score=2 STRING: ENSP00000263671
FST	P19883³, ENSP00000256759⁴	I2D: score=2 STRING: ENSP00000256759
ACVR1	Q04771³, ENSP00000263640⁴	I2D: score=1 STRING: ENSP00000263640

About this table

Gene Ontology (GO): 5/41 biological process terms (GO ID links to tree view) (see all 41): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	IDA	9884026
GO:0001541	ovarian follicle development	NAS	9166111
GO:0001707	mesoderm formation	--	--
GO:0001942	hair follicle development	IGI	10932194
GO:0002244	hematopoietic progenitor cell differentiation	IDA	15451575

INHBA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

INHBA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for INHBA
7 Novoseek chemical compound relationships for INHBA gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
5-aza-2'deoxycytidine	29	5	19308293 (2), 19240652 (1)
oligonucleotide	22.7	5	19240652 (2), 10810314 (1), 19308293 (1), 1863557 (1)
progesterone	12.4	1	10965925 (1)
testosterone	9.39	1	1750706 (1)
cycloheximide	2.59	1	10906757 (1)
forskolin	1.38	2	12538609 (1)
estrogen	0	2	7536182 (1)

Search CenterWatch for drugs/clinical trials and news about INHBA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for INHBA gene:

NM_002192.2

Unigene Cluster for INHBA:

Inhibin, beta A

Hs.583348 [show with all ESTs]

Unigene Representative Sequence: BX648811

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000242208(uc003thq.3 uc003thr.3) ENST00000464515 ENST00000442711

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		5 QIAGEN miScript miRNA Assays for microRNAs that regulate INHBA:
		hsa-miR-1233 hsa-miR-135b hsa-miR-205 hsa-miR-452* hsa-miR-135a
		SwitchGear 3'UTR luciferase reporter plasmid: INHBA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INHBA

Additional cDNA sequence:

AF218018.1 AK222742.1 AK290584.1 BC007858.2 BX648811.1 D49743.1 J03634.1 M13436.1

X72498.1

9 DOTS entries:

DT.91741308 DT.452433 DT.92030578 DT.92008315 DT.99942006 DT.100707716 DT.102831894 DT.40316631

DT.95173216

24/110 AceView cDNA sequences (see all 110):

AI738775 CA310336 AU139087 AI905388 BP341643 BQ574581 CN480753 CD367517

BM555692 BF439415 AA948385 AL599843 CK825381 AI753619 BQ006749 CD366041

BQ267396 BC007858 BF000451 BQ003646 T29604 BM554468 AI188646 BG747890

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

INHBA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCGTGGAGG

About this image

INHBA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Pancreas

Dorsal Pancreatic Bud

Alpha Progenitor Cells

Pancreas

Ventral Pancreatic Bud

Alpha Progenitor Cells

Pancreas

Early Embryo

Developing Peritubular Myoid Cells

Reproductive System

Heart

Endocardium

Cushion Mesenchymal Cells

Endocardium

Cartilage

Lumbar Intervertebral Disc

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mature follicles (In-vitro growth and ...)

See INHBA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INHBA

SOURCE GeneReport for Unigene cluster: Hs.583348

SABiosciences Expression via Pathway-Focused PCR Arrays including INHBA (see all 8):

Growth Factors in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Common Cytokines in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INHBA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for INHBA gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	INHBA¹	inhibin, beta A	80.35(n) 84.43(a)		396361 NM_205396.1 NP_990727.1
lizard (Anolis carolinensis)	Reptilia	INHBA⁶	--	83(a)	1 ↔ 1	6(49715246-49730887)
zebrafish (Danio rerio)	Actinopterygii	AF475092.1²	--	75.89(n)		30072 AF475092.1
fruit fly (Drosophila melanogaster)	Insecta	Actbeta¹	Activin-beta	46.42(n) 35.57(a)		43826 NM_143685.2 NP_651942.2

ENSEMBL Gene Tree for INHBA (if available)
TreeFam Gene Tree for INHBA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for INHBA gene

TGFB3² INHBC² GDF11² MSTN² INHBE² TGFB1² INHBB² TGFB2²

2 SIMAP similar genes for INHBA using alignment to 2 protein entries: INHBA_HUMAN (see all proteins):

DKFZp686A06204 INHBB

INHBA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145663506^1,2		--	41728140(+)	`AATAAC/TAATTA`	1	--	ds500¹		0	--	--	--	--
rs150682343^1,2		--	41728251(+)	`GAAAAC/TACTTG`	1	--	ds500¹		0	--	--	--	--
rs151200370^1,2		--	41728310(+)	`CGATT-/AAAAAA`	1	--	ds500¹		0	--	--	--	--
rs115124068^1,2	C,F,	--	41728654(+)	`ACACGA/CTTGTT`	1	--	ut3¹		1		WA	118
rs139104018^1,2	C,	--	41728701(+)	`ATGCC-/TGTGTG TGTGT`	1	--	ut3¹		0	--	--	--	--
rs139923980^1,2		--	41728811(+)	`CCTGTC/GATGGG`	1	--	ut3¹		0	--	--	--	--
rs182551348^1,2		--	41728877(+)	`CTGCAA/GACTAG`	1	--	ut3¹		0	--	--	--	--
rs187123304^1,2		--	41728937(+)	`TACCCC/TGTTTA`	1	--	ut3¹		0	--	--	--	--
rs191980835^1,2		--	41729022(+)	`TCTCTC/TTCACT`	1	--	ut3¹		0	--	--	--	--
rs151304258^1,2		--	41729107(+)	`TTTTG-/TTTTTT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for INHBA (41724712 - 41742706 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for INHBA: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

INHBA for disorders           About GeneDecksing

OMIM gene information: 147290    OMIM disorders: --

20/73 diseases for INHBA (see all 73):    About MalaCards

pre-eclampsia testicular germ cell tumor dental caries ectopic pregnancy

clear cell adenocarcinoma familial adenomatous polyposis germ cell tumor ovarian clear cell adenocarcinoma

premature ovarian failure polycystic ovary syndrome intrauterine infections myocardial infarction

acute myocardial infarction somatotrophinoma esophageal squamous cell carcinoma squamous cell carcinoma

pancreatic ductal adenocarcinoma inflammatory bowel disease goiter brain injury

10/14 Novoseek disease relationships for INHBA gene (see all 14) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sex cord-stromal tumor	56.7	4	10747314 (3)
erythroleukemia	46.2	3	1542647 (1), 1402687 (1), 2323849 (1)
esophageal carcinoma	40.4	6	15355896 (1), 18695873 (1), 12469187 (1), 17909904 (1)
epithelial tumor	20.8	1	10747314 (1)
tumors	19.8	18	10747314 (3), 17609433 (2), 12206515 (2), 7829603 (1) (see all 9)
pheochromocytoma	19.8	5	10810314 (3), 11344232 (1), 17680997 (1)
adenoma	14.7	5	9691207 (1), 7599706 (1), 12821114 (1)
goiter	14.6	2	11069203 (1), 12729472 (1)
endometrial carcinoma	13.8	1	11585411 (1)
carcinoma	11.5	4	19308293 (1), 9570994 (1), 17909904 (1), 12729472 (1)

Genetic Association Database (GAD): INHBA
Human Genome Epidemiology (HuGE) Navigator: INHBA (15 documents)

Export disorders for INHBA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for INHBA gene, integrated from 9 sources (see all 275):
(articles sorted by number of sources associating them with INHBA)

Utopia: connect your pdf to the dynamic
world of online information

The structure of FSTL3.activin A complex. Differential binding of N- terminal domains influences follistatin-type antagonist specificity. (PubMed id 18768470)^{1, 2} Stamler R....Thompson T.B. (2008)
Mutational analysis of the mature peptide region of inhibin genes in Indian women with ovarian failure. (PubMed id 15205401)^{1, 4} Dixit H....Singh L. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions. (PubMed id 12660162)^{1, 2} Thompson T.B.... Jardetzky T.S. (2003)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG). (PubMed id 12697670)^{1, 2} Schneyer A....Sidis Y. (2003)
Structure and sequence analysis of the human activin beta A subunit gene. (PubMed id 1777673)^{1, 2} Tanimoto K.... Fukamizu A. (1991)
Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain. (PubMed id 3267209)^{1, 2} Murata M.... Muramatsu M. (1988)
Inhibin: definition and nomenclature, including related substances. (PubMed id 3345731)^{1, 3} Burger H.G. and Igarashi M. (1988)
Structure of two human ovarian inhibins. (PubMed id 3754442)^{1, 2} Mason A.J.... Seeburg P.H. (1986)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3624	HGNC: 6066	AceView: INHBA	Ensembl:ENSG00000122641	euGenes: HUgn3624
ECgene: INHBA	Kegg: 3624	H-InvDB: INHBA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for INHBA	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for INHBA	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Activin

Intellectual Property for INHBA gene
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Patent Information for INHBA gene:
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GeneCards and IP:
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