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Aliases for INHA Gene

Aliases for INHA Gene

  • Inhibin Alpha 2 3 5
  • Inhibin, Alpha 2

External Ids for INHA Gene

Previous GeneCards Identifiers for INHA Gene

  • GC02P218459
  • GC02P219158
  • GC02P220400
  • GC02P220639
  • GC02P220262
  • GC02P220145
  • GC02P220433
  • GC02P212289

Summaries for INHA Gene

Entrez Gene Summary for INHA Gene

  • This gene encodes a member of the TGF-beta superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mice in which a similar gene has been ablated exhibit sex cord-stromal tumors and symptoms that mimic the human cancer cachexia syndrome. [provided by RefSeq, Jan 2016]

GeneCards Summary for INHA Gene

INHA (Inhibin Alpha) is a Protein Coding gene. Diseases associated with INHA include Sex Cord-Gonadal Stromal Tumor and Sertoli Cell Tumor. Among its related pathways are Ovarian Infertility Genes and Peptide hormone metabolism. GO annotations related to this gene include protein heterodimerization activity and cytokine activity.

UniProtKB/Swiss-Prot for INHA Gene

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Gene Wiki entry for INHA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INHA Gene

Genomics for INHA Gene

Regulatory Elements for INHA Gene

Enhancers for INHA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around INHA on UCSC Golden Path with GeneCards custom track

Promoters for INHA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around INHA on UCSC Golden Path with GeneCards custom track

Genomic Location for INHA Gene

Chromosome:
2
Start:
219,569,162 bp from pter
End:
219,575,713 bp from pter
Size:
6,552 bases
Orientation:
Plus strand

Genomic View for INHA Gene

Genes around INHA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INHA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INHA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INHA Gene

Proteins for INHA Gene

  • Protein details for INHA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05111-INHA_HUMAN
    Recommended name:
    Inhibin alpha chain
    Protein Accession:
    P05111
    Secondary Accessions:
    • A8K8H5

    Protein attributes for INHA Gene

    Size:
    366 amino acids
    Molecular mass:
    39670 Da
    Quaternary structure:
    • Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.

neXtProt entry for INHA Gene

Proteomics data for INHA Gene at MOPED

Post-translational modifications for INHA Gene

  • Proteolytic processing yields a number of bioactive forms. The 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono- or diglycosylated, causing the mass difference.
  • Glycosylation at Asn 146, Asn 268, and Asn 302
  • Modification sites at PhosphoSitePlus

Other Protein References for INHA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for INHA Gene

Domains & Families for INHA Gene

Suggested Antigen Peptide Sequences for INHA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05111

UniProtKB/Swiss-Prot:

INHA_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with INHA: view

No data available for Gene Families for INHA Gene

Function for INHA Gene

Molecular function for INHA Gene

GENATLAS Biochemistry:
inhibin,alpha subunit,18kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,to form inhibitin A or B respectively,inhibitors of FSH secretion,homodimerizing to form activing A stimulator of FSH secretion and involved in embryonic axis development or heterodimerizing with INHBB or INHA to form activin AB or inhibitin B,respectively
UniProtKB/Swiss-Prot Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Gene Ontology (GO) - Molecular Function for INHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005160 transforming growth factor beta receptor binding IBA --
genes like me logo Genes that share ontologies with INHA: view
genes like me logo Genes that share phenotypes with INHA: view

Animal Models for INHA Gene

MGI Knock Outs for INHA:

Animal Model Products

miRNA for INHA Gene

miRTarBase miRNAs that target INHA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INHA Gene

Localization for INHA Gene

Subcellular locations from UniProtKB/Swiss-Prot for INHA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INHA Gene COMPARTMENTS Subcellular localization image for INHA gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
nucleus 1

Gene Ontology (GO) - Cellular Components for INHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034673 inhibin-betaglycan-ActRII complex IDA 10746731
GO:0043512 inhibin A complex IEA,IDA 7890768
genes like me logo Genes that share ontologies with INHA: view

Pathways & Interactions for INHA Gene

genes like me logo Genes that share pathways with INHA: view

Pathways by source for INHA Gene

1 Sino Biological pathway for INHA Gene
1 BioSystems pathway for INHA Gene

SIGNOR curated interactions for INHA Gene

Inactivates:

Gene Ontology (GO) - Biological Process for INHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS 12456957
GO:0007165 signal transduction TAS 3267209
GO:0007267 cell-cell signaling TAS 12456957
GO:0007399 nervous system development NAS 10320815
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA --
genes like me logo Genes that share ontologies with INHA: view

Drugs & Compounds for INHA Gene

(21) Drugs for INHA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(13) Additional Compounds for INHA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INHA: view

Transcripts for INHA Gene

mRNA/cDNA for INHA Gene

Unigene Clusters for INHA Gene

Inhibin, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INHA Gene

No ASD Table

Relevant External Links for INHA Gene

GeneLoc Exon Structure for
INHA
ECgene alternative splicing isoforms for
INHA

Expression for INHA Gene

mRNA expression in normal human tissues for INHA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INHA Gene

This gene is overexpressed in Ovary (x14.3), Testis (x11.4), and Adrenal Gland (x9.3).

Protein differential expression in normal tissues from HIPED for INHA Gene

This gene is overexpressed in Testis (46.9), Fetal ovary (11.6), and Fetal testis (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for INHA Gene



SOURCE GeneReport for Unigene cluster for INHA Gene Hs.407506

mRNA Expression by UniProt/SwissProt for INHA Gene

P05111-INHA_HUMAN
Tissue specificity: Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.
genes like me logo Genes that share expression patterns with INHA: view

Protein tissue co-expression partners for INHA Gene

- Elite partner

Primer Products

Orthologs for INHA Gene

This gene was present in the common ancestor of chordates.

Orthologs for INHA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia INHA 35
  • 85.1 (n)
  • 83.67 (a)
INHA 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INHA 35
  • 83.47 (n)
  • 79.44 (a)
INHA 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inha 35
  • 82.61 (n)
  • 80.69 (a)
Inha 16
Inha 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia INHA 35
  • 99.36 (n)
  • 98.91 (a)
INHA 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inha 35
  • 82.44 (n)
  • 80.17 (a)
oppossum
(Monodelphis domestica)
Mammalia INHA 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INHA 36
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves INHA 35
  • 63.77 (n)
  • 56.59 (a)
INHA 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INHA 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia inha 35
  • 57.25 (n)
  • 50.32 (a)
zebrafish
(Danio rerio)
Actinopterygii inha 35
  • 49.9 (n)
  • 38.68 (a)
inha 36
  • 36 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9068 35
Species with no ortholog for INHA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INHA Gene

ENSEMBL:
Gene Tree for INHA (if available)
TreeFam:
Gene Tree for INHA (if available)

Paralogs for INHA Gene

(5) SIMAP similar genes for INHA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INHA: view

No data available for Paralogs for INHA Gene

Variants for INHA Gene

Sequence variations from dbSNP and Humsavar for INHA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs12720062 - 219,575,194(+) AACCG(A/G)CTGCC reference, missense
rs12720061 - 219,575,104(+) GTGGA(A/G)GGGAG reference, missense
VAR_072639 -
rs2229913 -- 219,575,538(+) GGGGT(C/G)TTCCT utr-variant-3-prime
rs2229914 -- 219,575,531(+) AGGGT(C/G/T)GGGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for INHA Gene

Variant ID Type Subtype PubMed ID
dgv4438n71 CNV Loss 21882294
nsv875876 CNV Loss 21882294
nsv834545 CNV Loss 17160897
nsv508887 CNV Insertion 20534489

Variation tolerance for INHA Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INHA Gene

Human Gene Mutation Database (HGMD)
INHA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INHA Gene

Disorders for INHA Gene

MalaCards: The human disease database

(43) MalaCards diseases for INHA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sex cord-gonadal stromal tumor
  • malignant testicular sex cord-stromal tumor
sertoli cell tumor
  • tubular androblastoma nos
multidrug-resistant tuberculosis
  • tuberculosis multidrug-resistant
granular cell tumor
  • granular cell tumor nos
cystadenoma
  • cystoma
- elite association - COSMIC cancer census association via MalaCards
Search INHA in MalaCards View complete list of genes associated with diseases

Relevant External Links for INHA

Genetic Association Database (GAD)
INHA
Human Genome Epidemiology (HuGE) Navigator
INHA
Tumor Gene Database (TGDB):
INHA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INHA
genes like me logo Genes that share disorders with INHA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INHA Gene

Publications for INHA Gene

  1. Investigating the association between inhibin alpha gene promoter polymorphisms and premature ovarian failure. (PMID: 18249384) Woad K.J. … Shelling A.N. (Fertil. Steril. 2009) 3 23 48 67
  2. Calponin is expressed in serous cystadenomas of the pancreas but not in adenocarcinomas or endocrine tumors. (PMID: 19391217) Marsh W.L. … Frankel W.L. (Appl. Immunohistochem. Mol. Morphol. 2009) 3 23
  3. Expression of estrogen and progesterone receptors and inhibin-alpha in hepatobiliary cystadenoma: an immunohistochemical study. (PMID: 17457606) Abdul-Al H.M. … Goodman Z.D. (Virchows Arch. 2007) 3 23
  4. Immunoreactivity of CD10 and inhibin alpha in differentiating hemangioblastoma of central nervous system from metastatic clear cell renal cell carcinoma. (PMID: 15578072) Jung S.M. … Kuo T.T. (Mod. Pathol. 2005) 3 23
  5. Inhibin alpha-subunit and the inhibin coreceptor betaglycan are downregulated in endometrial carcinoma. (PMID: 15745937) Florio P. … Petraglia F. (Eur. J. Endocrinol. 2005) 3 23

Products for INHA Gene

Sources for INHA Gene

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