Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

INHA Gene

protein-coding GIFtS: 65
GCID: GC02P220433

inhibin, alpha

Explore 99 diseases affiliated with
INHA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Inhibin, Alpha¹ ²
A-Inhibin Subunit²
Inhibin Alpha Chain²

External Ids:	HGNC: 6065¹	Entrez Gene: 3623²	Ensembl: ENSG00000123999⁷	OMIM: 147380⁵	UniProtKB: P05111³

Export aliases for INHA gene to outside databases

Previous GC identifers: GC02P218459 GC02P219158 GC02P220400 GC02P220639 GC02P220262 GC02P220145 GC02P212289

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INHA:

This gene encodes the alpha subunit of inhibins A and B protein complexes. These complexes negatively regulate follicle

stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous

cellular processes including cell proliferation, apoptosis, immune response and hormone secretion.(provided by RefSeq,

Dec 2010)

UniProtKB/Swiss-Prot: INHA_HUMAN, P05111

Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary

gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary

hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin

secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.

Inhibins appear to oppose the functions of activins

Gene Wiki entry for INHA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the INHA gene promoter:
GR Pax-5 GATA-6 p53 GR-alpha GATA-2 E47 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: INHA promoter sequence

Search SABiosciences Chromatin IP Primers for INHA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INHA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33-q36 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q33-qter

INHA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INHA gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P220433: view genomic region (about GC identifiers)

Start:	220,433,884 bp from pter	End:	220,440,435 bp from pter
Size:	6,552 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: INHA_HUMAN, P05111 (See protein sequence)

Recommended Name: Inhibin alpha chain precursor

Size: 366 amino acids; 39670 Da

Subunit: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer

of alpha and beta-B

Subcellular location: Secreted

Secondary accessions: A8K8H5

Explore the universe of human proteins at neXtProt for INHA: NX_P05111

Post-translational modifications:

Proteolytic processing yields a number of bioactive forms. The 20/23 kDa forms consist solely of the mature alpha

chain, the 26/29 kDa forms consist of the most N-terminal propeptide linked through a disulfide bond to the mature

alpha chain, the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono- or

diglycosylated, causing the mass difference¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05111

INHA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002182.1

ENSEMBL proteins:

ENSP00000243786

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: INHA OriGene Custom Protein Services for INHA
	GenScript Custom Purified and Recombinant Proteins Services for INHA
	Novus Biologicals INHA Proteins Novus Biologicals INHA Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for INHA
	Uscn Proteins for INHA

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001750	photoreceptor outer segment	IEA	--
GO:0001917	photoreceptor inner segment	IEA	--
GO:0005576	extracellular region	TAS	12456957
GO:0005615	extracellular space	--	--
GO:0034673	inhibin-betaglycan-ActRII complex	IDA	10746731

INHA for ontologies About GeneDecksing

INHA Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: INHA OriGene Custom Antibody Services for INHA
	GenScript Custom Superior Antibodies Services for INHA
	Novus Biologicals INHA Antibodies
	Abcam antibodies for INHA
	Uscn Antibodies for INHA
	ThermoFisher Antibodies for INHA

Assay Products for INHA:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for INHA
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for INHA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

INHA for domains About GeneDecksing

4 InterPro domains/families:

IPR002405 Inhibin_asu

IPR017175 Inhibin_asu_subgr

IPR001839 TGF-b_C

IPR017948 TGFb_CS

Graphical View of Domain Structure for InterPro Entry P05111

ProtoNet protein and cluster: P05111

2 Blocks protein families:

IPB001839 Transforming growth factor beta (TGFb)

IPB002405 Inhibin alpha chain signature

UniProtKB/Swiss-Prot: INHA_HUMAN, P05111

Similarity: Belongs to the TGF-beta family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: INHA_HUMAN, P05111

Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary

gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary

hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin

secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.

Inhibins appear to oppose the functions of activins

Genatlas biochemistry entry for INHA:

inhibin,alpha subunit,18kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,to form inhibitin A or B

respectively,inhibitors of FSH secretion,homodimerizing to form activing A stimulator of FSH secretion and involved in

embryonic axis development or heterodimerizing with INHBB or INHA to form activin AB or inhibitin B,respectively

miRNA Products:		OriGene 3'-UTR Clone: INHA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INHA
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate INHA
		SwitchGear 3'UTR luciferase reporter plasmid: INHA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INHA (see all 7) OriGene shRNA RFP: INHA OriGene siRNA: INHA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INHA

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for INHA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INHA (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INHA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: INHA (NM_002191)
		Sino Biological Human cDNA Clone for INHA
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for INHA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INHA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for INHA
		Search LifeMap BioReagents cell lines for INHA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHA

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IPI	9032295
GO:0005125	cytokine activity	TAS	12456957
GO:0005179	hormone activity	TAS	12456957
GO:0005515	contributes to protein binding	IPI	10746731
GO:0008083	growth factor activity	TAS	12324653

INHA for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for INHA:

Decreased cell number and incr

Animal Models:
Mouse knock-out Inha^tm1Bay for INHA
13 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Inha):

cardiovascular system	digestive/alimentary	endocrine/exocrine gland	growth/size	hematopoietic system
homeostasis/metabolism	immune system	liver/biliary system	mortality/aging	normal
reproductive system	skeleton	tumorigenesis

INHA for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signal transduction Activin A signaling regulation

Signal transduction Activin A signaling regulation

1.00

Signal transduction_Activin A signaling regulation

0.96

Ovarian Infertility Genes

Ovarian Infertility Genes

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for INHA

Signal transduction Activin A signaling regulation

1 GeneGo (Thomson Reuters) Pathway for INHA

Signal transduction Activin A signaling regulation

1 BioSystems Pathway for INHA

Ovarian Infertility Genes

INHA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for INHA

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/9 Interacting proteins for INHA (P05111³ ENSP00000243786⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FST	P19883³, ENSP00000256759⁴	I2D: score=1 STRING: ENSP00000256759
TGFBR3	Q03167³, ENSP00000212355⁴	I2D: score=1 STRING: ENSP00000212355
ACVR2A	P27037³, ENSP00000241416⁴	I2D: score=1 STRING: ENSP00000241416
INHBA	P08476³, ENSP00000242208⁴	I2D: score=1 STRING: ENSP00000242208
INHBB	P09529³, ENSP00000295228⁴	I2D: score=1 STRING: ENSP00000295228

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	TAS	10865214
GO:0001541	ovarian follicle development	NAS	9166111
GO:0006917	induction of apoptosis	IDA	8267637
GO:0007050	cell cycle arrest	TAS	12456957
GO:0007165	signal transduction	TAS	3267209

INHA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

INHA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for INHA
10/34 Novoseek chemical compound relationships for INHA gene (see all 34) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
isoniazid	89	119	15854436 (5), 12543676 (4), 14974741 (3), 7599116 (3) (see all 74)
manganese(iii) pyrophosphate	80.4	1	11948876 (1)
rifampicin	77.5	48	19893355 (3), 18560033 (2), 19172878 (2), 17897230 (2) (see all 30)
ethionamide	76.1	10	19861006 (3), 7599116 (2), 14638486 (1), 19486070 (1) (see all 6)
progesterone	61.5	51	8080927 (6), 12783698 (3), 16580171 (3), 16831355 (3) (see all 24)
ethambutol	60.1	3	9494673 (1), 16870753 (1), 17360809 (1)
streptomycin	57.1	6	9494673 (1), 11601331 (1), 16249627 (1), 11796356 (1)
ribonucleic acid	55.8	7	8886632 (2), 1955539 (2), 1892206 (1), 11710435 (1) (see all 5)
pyrazinamide	49.5	2	9494673 (1), 17360809 (1)
testosterone	46.3	15	2307118 (4), 7608253 (2), 10569979 (1), 16429274 (1) (see all 11)

Search CenterWatch for drugs/clinical trials and news about INHA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for INHA gene:

NM_002191.3

Unigene Cluster for INHA:

Inhibin, alpha

Hs.407506 [show with all ESTs]

Unigene Representative Sequence: BC039076

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000489456 ENST00000243786(uc002vmk.2)

miRNA Products:		OriGene 3'-UTR Clone: INHA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INHA
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate INHA
		SwitchGear 3'UTR luciferase reporter plasmid: INHA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INHA (see all 7) OriGene shRNA RFP: INHA OriGene siRNA: INHA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INHA

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INHA (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INHA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: INHA (NM_002191)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for INHA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INHA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INHA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat INHA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INHA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INHA

Additional cDNA sequence:

BC006391.2 BC039076.1 BT006954.1 M13144.1 M13981.1

5 DOTS entries:

DT.411686 DT.97823930 DT.97824402 DT.101961551 DT.91819820

24/55 AceView cDNA sequences (see all 55):

NM_002191 AI919290 BQ013783 M13981 BT006954 AW235196 CR617999 BC006391

BM711366 M13144 AU134634 BF312530 BI826892 BM670529 BI829338 AL540575

AU155550 BM546385 AI807888 BI520936 BM700412 AI351176 T29423 BE552259

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

INHA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGTTGTGG

About this image

INHA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Rod Bipolar Cells

Bipolar, Retina

Ovary

Skeletal Muscle

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See INHA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INHA

SOURCE GeneReport for Unigene cluster: Hs.407506

UniProtKB/Swiss-Prot: INHA_HUMAN, P05111

Tissue specificity: Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in

many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the

innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also

found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of

basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found

in male, whereas circulating inhibins A and B are found in female

SABiosciences Expression via Pathway-Focused PCR Arrays including INHA (see all 8):

Growth Factors in human mouse rat

Cell Cycle in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

Common Cytokines in human mouse rat

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INHA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat INHA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INHA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INHA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for INHA gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Inha^{1 , 5}	inhibin alpha^{1, 5}	82.5(n)¹ 79.72(a)¹		1 (39.16 cM)⁵ 16322¹ NM_010564.4¹ NP_034694.3¹ 75507077⁵
chicken (Gallus gallus)	Aves	INHA¹	inhibin, alpha	63.1(n) 55.66(a)		424197 NM_001031257.1 NP_001026428.1
lizard (Anolis carolinensis)	Reptilia	INHA⁶	--	49(a)	1 ↔ 1	1(94519299-94523134)
zebrafish (Danio rerio)	Actinopterygii	inha¹	inhibin, alpha	50.15(n) 38.77(a)		570520 NM_001045204.1 NP_001038669.1

ENSEMBL Gene Tree for INHA (if available)
TreeFam Gene Tree for INHA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111647913^1,2	C,	--	212289728(+)	`GTGTGT/AGAGAG`	3	--	us2k¹		1		CSA	2
rs72959667^1,2	C,	--	212289734(+)	`GAGAGT/AGTGTG`	3	--	us2k¹		1		CSA	2
rs74687137^1,2	C,F,	--	212289901(+)	`ATAAGG/ACTCAT`	3	--	us2k¹		1		WA	118
rs117544474^1,2	C,F,	--	212290514(+)	`AGCAAT/CAGGCC`	3	--	us2k¹		1		EA	120
rs12464250^1,2	C,H,	--	212290656(+)	`AGACCA/GGGGGT`	3	--	us2k¹		0	--	--	--	--
rs186208^1,2	H	--	212290697(+)	`CCCTTC/TCTGCC`	3	--	us2k¹		4		NS EA	418
rs62191616^1,2		--	212290794(+)	`ATACAG/TGCAAA`	3	--	us2k¹		2		NA	122
rs143377200^1,2		--	220436681(+)	`GTGTC-/TGTGTGT`	4	--	us2k¹		0	--	--	--	--
rs80038385^1,2	C,	--	220436694(+)	`GTGTGA/TGTGAG`	4	--	us2k¹		0	--	--	--	--
rs73089126^1,2	C,,	--	220436696(+)	`GTGTGT/AGAGAG`	4	--	us2k¹		1		CSA	2

HapMap Linkage Disequilibrium report for INHA (220433884 - 220440435 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for INHA: --
Human Gene Mutation Database (HGMD): INHA

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INHA

DNA2.0 Custom Variant and Variant Library Synthesis for INHA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

INHA for disorders           About GeneDecksing

OMIM gene information: 147380    OMIM disorders: --

20/99 diseases for INHA (see all 99):    About MalaCards

von hippel-lindau disease sex cord-gonadal stromal tumor sertoli-leydig cell tumor peutz-jeghers syndrome

mixed epithelial stromal tumour multidrug-resistant tuberculosis leydig cell tumor parovarian cyst

gestational trophoblastic neoplasm fallopian tube adenocarcinoma androgen insensitivity syndrome renal clear cell carcinoma

epithelioid trophoblastic tumor polycystic ovary syndrome sertoli cell tumor granular cell tumor

pre-eclampsia adenofibroma placental abruption serous cystadenoma

9 diseases from the University of Copenhagen DISEASES database for INHA:

Epithelioid trophoblastic tumor Sex cord-gonadal stromal tumor Premature ovarian failure Parovarian cyst

Sertoli cell tumor Leydig cell tumor Granular cell tumor Fallopian tube adenocarcinoma

Testicular cancer

10/80 Novoseek disease relationships for INHA gene (see all 80) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sex cord-stromal tumor	87.5	19	11192074 (3), 10747314 (2), 15256111 (2), 15381902 (1) (see all 11)
granulosa cell tumor	86.6	20	17609358 (4), 9190962 (3), 10843483 (3), 19115695 (2) (see all 12)
sertoli cell tumor	84.3	5	19255517 (1), 15363041 (1), 11971979 (1)
sertoli-leydig cell tumor	82.6	3	9475192 (1), 20158943 (1), 12502966 (1)
trophoblastic tumor	82.5	3	11603223 (2), 10202672 (1)
tuberculosis	76.1	146	15854436 (4), 11802940 (4), 8684371 (3), 20200152 (3) (see all 85)
trophoblastic tumor placental site	75	3	11603223 (2), 10202672 (1)
thecoma	72.4	1	20198651 (1)
adenoma adrenocortical	70	12	12910679 (4), 11556749 (2), 15256108 (1), 15970011 (1) (see all 6)
stromal tumors	69.3	5	15059165 (3), 11192073 (1)

Genetic Association Database (GAD): INHA
Human Genome Epidemiology (HuGE) Navigator: INHA (35 documents)
Tumor Gene Database (TGDB): INHA

Export disorders for INHA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for INHA gene, integrated from 9 sources (see all 510):
(articles sorted by number of sources associating them with INHA)

Utopia: connect your pdf to the dynamic
world of online information

INHA promoter polymorphisms are associated with premature ovarian failure. (PubMed id 16390856)^{1, 4, 9} Harris S.E....Shelling A.N. (2005)
Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer. (PubMed id 9506758)^{1, 2, 9} Mellor S.L....Risbridger G.P. (1998)
Controversial role of inhibin alpha-subunit gene in the aetiology of premature ovarian failure. (PubMed id 16396934)^{1, 4} Sundblad V....Dain L. (2006)
Mutational analysis of the inhibin alpha gene in preeclamptic women. (PubMed id 15816368)^{1, 4} Ciarmela P....Petraglia F. (2005)
[The use of DNA analysis for diagnostics of hereditary premature ovarian failure] (PubMed id 16161415)^{1, 4} Livshyts' H.B....Sudoma I.A. (2005)
G769A variation of inhibin alpha-gene in korean women with premature ovarian failure. (PubMed id 15227735)^{1, 4} Jeong H.J....Cha K.Y. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mutation analysis of the inhibin alpha gene in a cohort of Italian women affected by ovarian failure. (PubMed id 12093833)^{1, 4} Marozzi A....Ginelli E. (2002)
Inhibin: a candidate gene for premature ovarian failure. (PubMed id 11098038)^{1, 2} Shelling A.N....Winship I.M. (2000)
Characterization and determination of the biological activities of noncleavable high molecular weight forms of inhibin A and activin A. (PubMed id 8885240)^{1, 2} Mason A.J.... Sullivan J. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3623	HGNC: 6065	AceView: INHA	Ensembl:ENSG00000123999	euGenes: HUgn3623
ECgene: INHA	H-InvDB: INHA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for INHA	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for INHA	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Inhibin

Intellectual Property for INHA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for INHA gene:
Search GeneIP for patents involving INHA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for INHA		OriGene shRNA RFP for INHA
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INHA		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INHA
	OriGene Protein Over-expression Lysate for INHA		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for INHA		OriGene 3'-UTR Clone for INHA
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INHA		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INHA
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for INHA		OriGene Custom Protein Services for INHA
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INHA
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INHA
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INHA
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INHA
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INHA
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INHA

	GenScript Custom Purified and Recombinant Proteins Services for INHA		GenScript cDNA clones with any tag delivered in your preferred vector for INHA
	GenScript Custom Assay Services for INHA		GenScript Custom Superior Antibodies Services for INHA
	GenScript Custom overexpressing Cell Line Services for INHA		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in INHA promoter
	Search Chromatin IP Primers for INHA
	RT² qPCR Primer Assay in human, mouse, rat INHA
	GNC Network for INHA
	SABiosciences PCR Arrays including human, mouse, rat INHA

Search Tocris compounds for INHA

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for INHA
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	INHA antibodies
	INHA proteins
	INHA lysates

	Antibodies for INHA
	See all of Abcam's Antibodies, Kits and Proteins for INHA
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for INHA

INHA Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for INHA

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHA

	SwitchGear 3'UTR luciferase reporter plasmids for INHA
	SwitchGear Promoter luciferase reporter plasmids for INHA

ThermoFisher Antibodies for INHA

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INHA

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes INHA gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

INHA Gene

inhibin, alpha

Aliases
for INHA gene

Summaries
for INHA gene

Genomic Views
for INHA gene

Proteins
for INHA gene

Protein Domains /
Families
for INHA gene

Function
for INHA gene

Pathways & Interactions
for INHA gene

Drugs & Compounds
for INHA gene

Transcripts
for INHA gene

Expression
for INHA gene

Orthologs
for INHA gene

Paralogs
for INHA gene

Genomic Variants
for INHA gene

Disorders / Diseases
for INHA gene

Publications
for INHA gene

External Searches for INHA gene

Genome Databases showing INHA gene

Other Databases showing INHA gene

Specialized Databases showing INHA gene

Intellectual Property
for INHA gene

Products
for INHA gene

View Random Gene

Down Syndrome
Thecoma
Infertility
von Hippel-Lindau Disease
Breast Cancer
Dysgerminoma
Adenocarcinoma
Seminoma
Cancer
Klinefelters Syndrome
Rhabdomyosarcoma
Lymphoma
Miscarriage
Ovarian Cancer
Hamartoma
Tuberculosis
Cysts
Gynecomastia
ENDOMETRIAL CARCINOMA
Sex Cord-Stromal Tumor
prostate cancer
Tumors
Metastasis
Pheochromocytoma
Carcinoma Ductal
Autoimmunity
Atresia
Preeclampsia
Cushing Syndrome
renal clear cell carcinoma
Adenoma Adrenocortical
Ovarian Neoplasms
Melanoma
Brain Tumors
Sarcoma Endometrial Stromal
Tuberculosis Pulmonary
TWINNING, DIZYGOTIC
Hyperplasia
PITUITARY ADENOMA
Peutz-Jeghers Syndrome
Germinoma
Cystadenoma
Astrocytoma
Carcinoma
Trophoblastic Tumor Placental Site
PROSTATE CARCINOMA
epithelial tumor
METASTATIC CARCINOMA
Hydatidiform Mole
Ovarian Failure Premature
Carcinoma Endometrioid
Chordoma
Hemangioblastoma
Carcinoid
Carcinoma Renal Cell
small cell lung cancer
Wilms tumor
Adenofibroma
Carcinoma Adrenocortical
Granulosa Cell Tumor
Meningioma
Sertoli-Leydig Cell Tumor
Pancreatic tumor
Sertoli Cell Tumor
Adenoma
OVARIAN CARCINOMA
Adrenogenital Syndrome
OBESITY
Polycystic Ovary Syndrome
Carcinoma Squamous Cell
Trophoblastic disease
Schwannoma
ADRENAL TUMOR
Granular cell tumor
stromal tumors
Trophoblastic Tumor
Leiomyosarcoma
Tuberculosis Multidrug-Resistant
Yolk Sac Tumor
Choriocarcinoma

Advanced Search

Export list of displayed genes

INHA Gene

inhibin, alpha

Aliasesfor INHA gene

Summariesfor INHA gene

Genomic Viewsfor INHA gene

Proteinsfor INHA gene

Protein Domains /Familiesfor INHA gene

Functionfor INHA gene

Pathways & Interactionsfor INHA gene

Drugs & Compoundsfor INHA gene

Transcriptsfor INHA gene

Expression for INHA gene

Orthologsfor INHA gene

Paralogsfor INHA gene

Genomic Variantsfor INHA gene

Disorders / Diseasesfor INHA gene

Publicationsfor INHA gene

External Searches for INHA gene

Genome Databases showing INHA gene

Other Databases showing INHA gene

Specialized Databases showing INHA gene

Intellectual Propertyfor INHA gene

Productsfor INHA gene

View Random Gene

Aliases
for INHA gene

Summaries
for INHA gene

Genomic Views
for INHA gene

Proteins
for INHA gene

Protein Domains /
Families
for INHA gene

Function
for INHA gene

Pathways & Interactions
for INHA gene

Drugs & Compounds
for INHA gene

Transcripts
for INHA gene

Expression
for INHA gene

Orthologs
for INHA gene

Paralogs
for INHA gene

Genomic Variants
for INHA gene

Disorders / Diseases
for INHA gene

Publications
for INHA gene

Intellectual Property
for INHA gene

Products
for INHA gene