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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INHA Gene

protein-coding   GIFtS: 65
GCID: GC02P220433

Inhibin, Alpha

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Inhibin, Alpha1 2
A-Inhibin Subunit2
Inhibin Alpha Chain2

External Ids:    HGNC: 60651   Entrez Gene: 36232   Ensembl: ENSG000001239997   OMIM: 1473805   UniProtKB: P051113   

Export aliases for INHA gene to outside databases

Previous GC identifers: GC02P218459 GC02P219158 GC02P220400 GC02P220639 GC02P220262 GC02P220145 GC02P212289


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INHA Gene:
This gene encodes the alpha subunit of inhibins A and B protein complexes. These complexes negatively regulate
follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating
numerous cellular processes including cell proliferation, apoptosis, immune response and hormone
secretion.(provided by RefSeq, Dec 2010)

GeneCards Summary for INHA Gene: 
INHA (inhibin, alpha) is a protein-coding gene. Diseases associated with INHA include sertoli cell tumor, and multidrug-resistant tuberculosis, and among its related super-pathways are Histone modification. GO annotations related to this gene include growth factor activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot: INHA_HUMAN, P05111
Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and
pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid
differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on
their subunit composition. Inhibins appear to oppose the functions of activins

Gene Wiki entry for INHA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INHA gene promoter:
         GR   Pax-5   GATA-6   p53   GR-alpha   GATA-2   E47   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINHA promoter sequence
   Search SABiosciences Chromatin IP Primers for INHA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INHA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

INHA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INHA gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P220433:  view genomic region     (about GC identifiers)

Start:
220,433,884 bp from pter      End:
220,440,435 bp from pter
Size:
6,552 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INHA_HUMAN, P05111 (See protein sequence)
Recommended Name: Inhibin alpha chain precursor  
Size: 366 amino acids; 39670 Da
Subunit: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a
dimer of alpha and beta-B
Subcellular location: Secreted
Secondary accessions: A8K8H5

Explore the universe of human proteins at neXtProt for INHA: NX_P05111

Explore proteomics data for INHA at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytic processing yields a number of bioactive forms. The 20/23 kDa forms consist solely of the mature alpha
    chain, the 26/29 kDa forms consist of the most N-terminal propeptide linked through a disulfide bond to the
    mature alpha chain, the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either
    mono- or diglycosylated, causing the mass difference
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P05111

  • INHA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INHA Protein Expression
    REFSEQ proteins: NP_002182.1  
    ENSEMBL proteins: 
     ENSP00000243786  

    Human Recombinant Protein Products for INHA: 
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    OriGene Protein Over-expression Lysate for INHA
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    Novus Biologicals INHA Proteins
    Novus Biologicals INHA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for INHA
    Cloud-Clone Corp. Proteins for INHA 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001750photoreceptor outer segment IEA--
    GO:0001917photoreceptor inner segment IEA--
    GO:0005576extracellular region TAS12456957
    GO:0005615extracellular space ----
    GO:0034673inhibin-betaglycan-ActRII complex IDA10746731

    INHA for ontologies           About GeneDecksing



    INHA Antibody Products: 
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    Assay Products for INHA: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for INHA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR002405 Inhibin_asu
     IPR017175 Inhibin_asu_subgr
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P05111

    ProtoNet protein and cluster: P05111

    2 Blocks protein domains:
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002405 Inhibin alpha chain signature


    UniProtKB/Swiss-Prot: INHA_HUMAN, P05111
    Similarity: Belongs to the TGF-beta family


    INHA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INHA_HUMAN, P05111
    Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
    gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and
    pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid
    differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on
    their subunit composition. Inhibins appear to oppose the functions of activins

         Genatlas biochemistry entry for INHA:
    inhibin,alpha subunit,18kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,to form inhibitin A or B
    respectively,inhibitors of FSH secretion,homodimerizing to form activing A stimulator of FSH secretion and
    involved in embryonic axis development or heterodimerizing with INHBB or INHA to form activin AB or inhibitin
    B,respectively

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI9032295
    GO:0005125cytokine activity TAS12456957
    GO:0005179hormone activity TAS12456957
    GO:0005515contributes to protein binding IPI10746731
    GO:0008083growth factor activity TAS12324653
         
    INHA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for INHA:
     Decreased cell number and incr 

         13 MGI mutant phenotypes (inferred from 1 allele(MGI details for Inha):
     cardiovascular system  digestive/alimentary  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  normal 
     reproductive system  skeleton  tumorigenesis 

    INHA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Inhatm1Bay for INHA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for INHA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INHA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INHA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INHA 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidINHA 3' UTR sequence
    Inhib. RNA
    Products:
        
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    GenScript: all cDNA clones in your preferred vector: INHA (NM_002191)
    Sino Biological Human cDNA Clone for INHA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for INHA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31
    2Ovarian Infertility Genes
    Ovarian Infertility Genes
    3TGF-beta Signaling Pathway
    TGF-beta Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for INHA
        Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for INHA
        Signal transduction Activin A signaling regulation

    1 BioSystems Pathway for INHA
        Ovarian Infertility Genes

    1 Sino Biological Pathway for INHA 
        TGF-beta Signaling Pathway



    INHA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INHA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for INHA (P051113 ENSP000002437864) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FSTP198833, ENSP000002567594I2D: score=1 STRING: ENSP00000256759
    TGFBR3Q031673, ENSP000002123554I2D: score=1 STRING: ENSP00000212355
    ACVR2AP270373, ENSP000002414164I2D: score=1 STRING: ENSP00000241416
    INHBAP084763, ENSP000002422084I2D: score=1 STRING: ENSP00000242208
    INHBBP095293, ENSP000002952284I2D: score=1 STRING: ENSP00000295228
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS10865214
    GO:0001541ovarian follicle development NAS9166111
    GO:0007050cell cycle arrest TAS12456957
    GO:0007165signal transduction TAS3267209
    GO:0007166cell surface receptor signaling pathway TAS12456957

    INHA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INHA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INHA

    10/34 Novoseek inferred chemical compound relationships for INHA gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    isoniazid 89 119 15854436 (5), 12543676 (4), 14974741 (3), 7599116 (3) (see all 74)
    manganese(iii) pyrophosphate 80.4 1 11948876 (1)
    rifampicin 77.5 48 19893355 (3), 18560033 (2), 19172878 (2), 17897230 (2) (see all 30)
    ethionamide 76.1 10 19861006 (3), 7599116 (2), 14638486 (1), 19486070 (1) (see all 6)
    progesterone 61.5 51 8080927 (6), 12783698 (3), 16580171 (3), 16831355 (3) (see all 24)
    ethambutol 60.1 3 9494673 (1), 16870753 (1), 17360809 (1)
    streptomycin 57.1 6 9494673 (1), 11601331 (1), 16249627 (1), 11796356 (1)
    ribonucleic acid 55.8 7 8886632 (2), 1955539 (2), 1892206 (1), 11710435 (1) (see all 5)
    pyrazinamide 49.5 2 9494673 (1), 17360809 (1)
    testosterone 46.3 15 2307118 (4), 7608253 (2), 10569979 (1), 16429274 (1) (see all 11)

    Search CenterWatch for drugs/clinical trials and news about INHA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INHA gene: 
    NM_002191.3  

    Unigene Cluster for INHA:

    Inhibin, alpha
    Hs.407506  [show with all ESTs]
    Unigene Representative Sequence: BC039076
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489456 ENST00000243786(uc002vmk.2)
    miRNA
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INHA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INHA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INHA

    Additional mRNA sequence: 

    BC006391.2 BC039076.1 BT006954.1 M13144.1 M13981.1 

    5 DOTS entries:

    DT.411686  DT.97823930  DT.97824402  DT.101961551  DT.91819820 

    24/55 AceView cDNA sequences (see all 55):

    AI919290 BT006954 CR617999 BC006391 NM_002191 BQ013783 M13981 AW235196 
    BI829338 BI520936 BE552259 AL540575 M13144 BM804780 AI148801 CA487713 
    BM700412 AI351176 BM670529 AU134634 AI807888 BI826892 AA936078 BM906837 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INHA expression in normal human tissues (normalized intensities)      INHA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGTTGTGG
    INHA Expression
    About this image


    INHA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             XY Germ Cells Testis Cord
             Seminiferous Tubules
             testis ; cells in seminiferus ducts   
     
     Adrenal Gland (Endocrine System)    fully expand to see all 2 entries
             adrenal gland ; glandular cells   
             adrenal cortex   
     
     Ovary (Reproductive System)
             Ovary Interstitium
     
     Gonad
             XY Germ Cells Testis Cord
     
     Eye (Sensory Organs)
             Mature Rod Bipolar Cells Inner Nuclear Layer

    See INHA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INHA

    SOURCE GeneReport for Unigene cluster: Hs.407506

    UniProtKB/Swiss-Prot: INHA_HUMAN, P05111
    Tissue specificity: Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed
    in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and
    the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in
    hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic
    hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only
    circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female

        SABiosciences Expression via Pathway-Focused PCR Arrays including INHA (see all 8): 
              Growth Factors in human mouse rat
              Cell Cycle in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Common Cytokines in human mouse rat
              Apoptosis 384HT in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INHA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for INHA gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inha1 , 5 inhibin alpha1, 5 82.5(n)1
    79.72(a)1
      1 (39.16 cM)5
    163221  NM_010564.41  NP_034694.31 
     755070775 
    chicken
    (Gallus gallus)
    Aves INHA1 inhibin, alpha 63.1(n)
    55.66(a)
      424197  NM_001031257.1  NP_001026428.1 
    lizard
    (Anolis carolinensis)
    Reptilia INHA6
    Uncharacterized protein
    47(a)
    1 ↔ 1
    1(94516871-94523439)
    zebrafish
    (Danio rerio)
    Actinopterygii inha1 inhibin, alpha 50.15(n)
    38.77(a)
      570520  NM_001045204.1  NP_001038669.1 


    ENSEMBL Gene Tree for INHA (if available)
    TreeFam Gene Tree for INHA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INHA gene
    5 SIMAP similar genes for INHA using alignment to 2 protein entries:     INHA_HUMAN (see all proteins):
    BMP2    BMP3    GDF5    BMP7    NODAL

    INHA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/105 SNPs in INHA are shown (see all 105)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355522601,2
    C--219818770(+) TTTTT-/G/T/TT
            
    GGTGT
    1 -- int11NA 2
    rs113420371,2
    C,F--220438310(+) TCTTC-/T/TT  
            
    TTTTT
    1 -- int1 trp32NA CSA 4
    rs1437336541,2
    C--220438310(+) TCTTC-/TTTTTTT 1 -- int10--------
    rs2009293011,2
    --220438311(+) TTCTT-/CTTTTT 1 -- int10--------
    rs118905881,2
    C,F,H--220438312(+) TTCTTC/TTTTTT 1 -- int1 trp33Minor allele frequency- T:0.25NA WA 8
    rs1834369671,2
    --220438419(+) AGGCCA/GGGCGC 1 -- int10--------
    rs1437092731,2
    --220438530(+) CTCTAA/CTAAAA 1 -- int10--------
    rs2018041371,2
    C--220438539(+) AATAC-/AAAAAA 1 -- int10--------
    rs1877601251,2
    --220438573(+) GCTACC/TCGGGA 1 -- int10--------
    rs1480451791,2
    --220438642(+) TGAGCC/TGAGAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for INHA (220433884 - 220440435 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for INHA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508887CNV Insertion20534489
    dgv4438n71CNV Loss21882294
    nsv875876CNV Loss21882294
    nsv834545CNV Loss17160897


    Human Gene Mutation Database (HGMD): INHA
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147380    OMIM disorders: --

    20/91 diseases for INHA (see all 91):    About MalaCards
    sertoli cell tumor    multidrug-resistant tuberculosis    epithelioid trophoblastic tumor    sertoli-leydig cell tumor
    pleomorphic liposarcoma    mixed epithelial stromal tumour    invasive mole    ovarian small cell carcinoma
    parovarian cyst    fallopian tube adenocarcinoma    adenofibroma    clear cell renal cell carcinoma
    leydig cell tumor    pancreas adenocarcinoma    peutz-jeghers syndrome    conn's syndrome
    sex cord-gonadal stromal tumor    granular cell tumor    von hippel-lindau disease    ovarian endometriosis

    9 diseases from the University of Copenhagen DISEASES database for INHA:
    Epithelioid trophoblastic tumor     Sex cord-gonadal stromal tumor     Premature ovarian failure     Parovarian cyst
    Sertoli cell tumor     Leydig cell tumor     Granular cell tumor     Fallopian tube adenocarcinoma
    Testicular cancer

    INHA for disorders           About GeneDecksing

    10/80 Novoseek inferred disease relationships for INHA gene (see all 80)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sex cord-stromal tumor 87.5 19 11192074 (3), 10747314 (2), 15256111 (2), 15381902 (1) (see all 11)
    granulosa cell tumor 86.6 20 17609358 (4), 9190962 (3), 10843483 (3), 19115695 (2) (see all 12)
    sertoli cell tumor 84.3 5 19255517 (1), 15363041 (1), 11971979 (1)
    sertoli-leydig cell tumor 82.6 3 9475192 (1), 20158943 (1), 12502966 (1)
    trophoblastic tumor 82.5 3 11603223 (2), 10202672 (1)
    tuberculosis 76.1 146 15854436 (4), 11802940 (4), 8684371 (3), 20200152 (3) (see all 85)
    trophoblastic tumor placental site 75 3 11603223 (2), 10202672 (1)
    thecoma 72.4 1 20198651 (1)
    adenoma adrenocortical 70 12 12910679 (4), 11556749 (2), 15256108 (1), 15970011 (1) (see all 6)
    stromal tumors 69.3 5 15059165 (3), 11192073 (1)

    Genetic Association Database (GAD): INHA
    Human Genome Epidemiology (HuGE) Navigator: INHA (35 documents)
    Tumor Gene Database (TGDB): INHA

    Export disorders for INHA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INHA gene, integrated from 9 sources (see all 512):
    (articles sorted by number of sources associating them with INHA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Investigating the association between inhibin alpha gene promoter polymorphisms and premature ovarian failure. (PubMed id 18249384)1, 4, 9 Woad K.J....Shelling A.N. (2008)
    2. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PubMed id 18413775)1, 4, 9 Purdue M.P....McGlynn K.A. (2008)
    3. The 769G>A variant of the inhibin-alpha gene in Korean patients with preeclampsia. (PubMed id 18852530)1, 4, 9 Kim S.Y....Ryu H.M. (2008)
    4. INHA promoter polymorphisms are associated with premature ovarian failure. (PubMed id 16390856)1, 4, 9 Harris S.E....Shelling A.N. (2005)
    5. Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer. (PubMed id 9506758)1, 2, 9 Mellor S.L....Risbridger G.P. (1998)
    6. Genetic variation within the hypothalamus-pituitary-o varian axis in women with recurrent miscarriage. (PubMed id 20716560)1, 4 Hanna C.W....Robinson W.P. (2010)
    7. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    8. Inhibin and premature ovarian failure. (PubMed id 19752047)1, 4 Chand A.L....Shelling A.N. (2010)
    9. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolis m and breast cancer risk in the NCI breast and prostate cancer cohort consortiu m. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (2010)
    10. Quantitative trait loci predicting circulating sex st eroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3). (PubMed id 19574343)1, 4 Ahn J....Hayes R.B. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3623 HGNC: 6065 AceView: INHA Ensembl:ENSG00000123999 euGenes: HUgn3623
    ECgene: INHA H-InvDB: INHA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INHA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for INHA Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Inhibin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INHA gene:
    Search GeneIP for patents involving INHA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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