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Aliases for INHA Gene

Aliases for INHA Gene

  • Inhibin, Alpha 2 3

External Ids for INHA Gene

Summaries for INHA Gene

Entrez Gene Summary for INHA Gene

  • This gene encodes the alpha subunit of inhibins A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion.[provided by RefSeq, Dec 2010]

GeneCards Summary for INHA Gene

INHA (Inhibin, Alpha) is a Protein Coding gene. Diseases associated with INHA include parovarian cyst and fallopian tube adenocarcinoma. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and TGF-beta Signaling Pathway (sino). GO annotations related to this gene include protein heterodimerization activity and cytokine activity.

UniProtKB/Swiss-Prot for INHA Gene

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins

Gene Wiki entry for INHA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INHA Gene

Genomics for INHA Gene

Genomic Location for INHA Gene

Start:
219,569,162 bp from pter
End:
219,575,713 bp from pter
Size:
6,552 bases
Orientation:
Plus strand

Genomic View for INHA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INHA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INHA Gene

Regulatory Elements for INHA Gene

Proteins for INHA Gene

  • Protein details for INHA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05111-INHA_HUMAN
    Recommended name:
    Inhibin alpha chain
    Protein Accession:
    P05111
    Secondary Accessions:
    • A8K8H5

    Protein attributes for INHA Gene

    Size:
    366 amino acids
    Molecular mass:
    39670 Da
    Quaternary structure:
    • Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B

neXtProt entry for INHA Gene

Proteomics data for INHA Gene at MOPED

Post-translational modifications for INHA Gene

  • Proteolytic processing yields a number of bioactive forms. The 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono- or diglycosylated, causing the mass difference.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn146, Asn268, and Asn302

Other Protein References for INHA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for INHA Gene

Domains for INHA Gene

UniProtKB/Swiss-Prot:

INHA_HUMAN
Family:
  • Belongs to the TGF-beta family.:
    • P05111
genes like me logo Genes that share domains with INHA: view

No data available for Gene Families for INHA Gene

Function for INHA Gene

Molecular function for INHA Gene

GENATLAS Biochemistry: inhibin,alpha subunit,18kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,to form inhibitin A or B respectively,inhibitors of FSH secretion,homodimerizing to form activing A stimulator of FSH secretion and involved in embryonic axis development or heterodimerizing with INHBB or INHA to form activin AB or inhibitin B,respectively
UniProtKB/Swiss-Prot Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins

Gene Ontology (GO) - Molecular Function for INHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 9032295
GO:0005125 cytokine activity TAS 12456957
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0005179 hormone activity TAS 12456957
GO:0005515 contributes_to protein binding IPI 10746731
genes like me logo Genes that share ontologies with INHA: view
genes like me logo Genes that share phenotypes with INHA: view

Animal Models for INHA Gene

MGI Knock Outs for INHA:

miRNA for INHA Gene

miRTarBase miRNAs that target INHA

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for INHA Gene

Localization for INHA Gene

Subcellular locations from UniProtKB/Swiss-Prot for INHA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INHA Gene COMPARTMENTS Subcellular localization image for INHA gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for INHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IEA --
GO:0001917 photoreceptor inner segment IEA --
GO:0005576 extracellular region TAS 12456957
GO:0005615 extracellular space --
GO:0034673 inhibin-betaglycan-ActRII complex IDA 10746731
genes like me logo Genes that share ontologies with INHA: view

Pathways for INHA Gene

genes like me logo Genes that share pathways with INHA: view

Pathways by source for INHA Gene

1 Sino Biological pathway for INHA Gene
1 GeneGo (Thomson Reuters Life Sciences Research) pathway for INHA Gene

Gene Ontology (GO) - Biological Process for INHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 10865214
GO:0001541 ovarian follicle development NAS 9166111
GO:0007050 cell cycle arrest TAS 12456957
GO:0007165 signal transduction TAS 3267209
GO:0007166 cell surface receptor signaling pathway TAS 12456957
genes like me logo Genes that share ontologies with INHA: view

Compounds for INHA Gene

(34) Novoseek inferred chemical compound relationships for INHA Gene

Compound -log(P) Hits PubMed IDs
isoniazid 89 103
manganese(iii) pyrophosphate 80.4 1
rifampicin 77.5 36
ethionamide 76.1 9
progesterone 61.5 38
genes like me logo Genes that share compounds with INHA: view

Transcripts for INHA Gene

mRNA/cDNA for INHA Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(55) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INHA Gene

Inhibin, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INHA Gene

No ASD Table

Relevant External Links for INHA Gene

GeneLoc Exon Structure for
INHA
ECgene alternative splicing isoforms for
INHA

Expression for INHA Gene

mRNA expression in normal human tissues for INHA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INHA Gene

This gene is overexpressed in Ovary (14.3), Testis (11.4), and Adrenal Gland (9.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for INHA Gene

SOURCE GeneReport for Unigene cluster for INHA Gene Hs.407506

mRNA Expression by UniProt/SwissProt for INHA Gene

P05111-INHA_HUMAN
Tissue specificity: Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.
genes like me logo Genes that share expressions with INHA: view

Orthologs for INHA Gene

This gene was present in the common ancestor of chordates.

Orthologs for INHA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INHA 36
  • 99.36 (n)
  • 98.91 (a)
INHA 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INHA 36
  • 85.1 (n)
  • 83.67 (a)
INHA 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INHA 36
  • 83.47 (n)
  • 79.44 (a)
INHA 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inha 36
  • 82.61 (n)
  • 80.69 (a)
Inha 16
Inha 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INHA 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INHA 37
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inha 36
  • 82.44 (n)
  • 80.17 (a)
chicken
(Gallus gallus)
Aves INHA 36
  • 63.77 (n)
  • 56.59 (a)
INHA 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INHA 37
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia inha 36
  • 57.25 (n)
  • 50.32 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9068 36
zebrafish
(Danio rerio)
Actinopterygii inha 36
  • 49.9 (n)
  • 38.68 (a)
inha 37
  • 36 (a)
OneToOne
Species with no ortholog for INHA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INHA Gene

ENSEMBL:
Gene Tree for INHA (if available)
TreeFam:
Gene Tree for INHA (if available)

Paralogs for INHA Gene

Selected SIMAP similar genes for INHA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INHA: view

No data available for Paralogs for INHA Gene

Variants for INHA Gene

Sequence variations from dbSNP and Humsavar for INHA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2229913 -- 219,575,538(+) GGGGT(C/G)TTCCT utr-variant-3-prime
rs2229914 -- 219,575,531(+) AGGGT(G/T)GGGGG utr-variant-3-prime
rs7588807 -- 219,574,380(+) ACAAA(G/T)TCTTa intron-variant
rs7602141 -- 219,573,988(+) aaaaa(A/T)GGTAA intron-variant
rs10182701 -- 219,575,996(+) ACATG(A/C)CCACA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for INHA Gene

Variant ID Type Subtype PubMed ID
dgv4438n71 CNV Loss 21882294
nsv875876 CNV Loss 21882294
nsv834545 CNV Loss 17160897
nsv508887 CNV Insertion 20534489

Relevant External Links for INHA Gene

HapMap Linkage Disequilibrium report
INHA
Human Gene Mutation Database (HGMD)
INHA

Disorders for INHA Gene

(80) Novoseek inferred disease relationships for INHA Gene

Disease -log(P) Hits PubMed IDs
sex cord-stromal tumor 87.5 15
granulosa cell tumor 86.6 20
sertoli cell tumor 84.3 3
sertoli-leydig cell tumor 82.6 3
trophoblastic tumor 82.5 3

Relevant External Links for INHA

Genetic Association Database (GAD)
INHA
Human Genome Epidemiology (HuGE) Navigator
INHA
Tumor Gene Database (TGDB):
INHA
genes like me logo Genes that share disorders with INHA: view

No data available for UniProtKB/Swiss-Prot for INHA Gene

Publications for INHA Gene

  1. Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer. (PMID: 9506758) Mellor S.L. … Risbridger G.P. (J. Clin. Endocrinol. Metab. 1998) 3 4 23
  2. INHA promoter polymorphisms are associated with premature ovarian failure. (PMID: 16390856) Harris S.E. … Shelling A.N. (Mol. Hum. Reprod. 2005) 3 23 49
  3. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PMID: 18413775) Purdue M.P. … McGlynn K.A. (Cancer Res. 2008) 3 23 49
  4. The 769G>A variant of the inhibin-alpha gene in Korean patients with preeclampsia. (PMID: 18852530) Kim S.Y. … Ryu H.M. (J. Endocrinol. Invest. 2008) 3 23 49
  5. Investigating the association between inhibin alpha gene promoter polymorphisms and premature ovarian failure. (PMID: 18249384) Woad K.J. … Shelling A.N. (Fertil. Steril. 2009) 3 23 49

Products for INHA Gene

Sources for INHA Gene

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