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INHA Gene

protein-coding   GIFtS: 68
GCID: GC02P220433

Inhibin, Alpha

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Inhibin, Alpha1 2
A-Inhibin Subunit2
Inhibin Alpha Chain2

External Ids:    HGNC: 60651   Entrez Gene: 36232   Ensembl: ENSG000001239997   OMIM: 1473805   UniProtKB: P051113   
ORGUL members:         

Export aliases for INHA gene to outside databases

Previous GC identifers: GC02P218459 GC02P219158 GC02P220400 GC02P220639 GC02P220262 GC02P220145 GC02P212289


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INHA Gene:
This gene encodes the alpha subunit of inhibins A and B protein complexes. These complexes negatively regulate
follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating
numerous cellular processes including cell proliferation, apoptosis, immune response and hormone
secretion.(provided by RefSeq, Dec 2010)

GeneCards Summary for INHA Gene:
INHA (inhibin, alpha) is a protein-coding gene. Diseases associated with INHA include sertoli cell tumor, and pleomorphic liposarcoma. GO annotations related to this gene include cytokine activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot: INHA_HUMAN, P05111
Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and
pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid
differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on
their subunit composition. Inhibins appear to oppose the functions of activins

Gene Wiki entry for INHA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the INHA gene promoter:
         GR   Pax-5   GATA-6   p53   GR-alpha   GATA-2   E47   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINHA promoter sequence
   Search Chromatin IP Primers for INHA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INHA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

INHA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INHA gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P220433:  view genomic region     (about GC identifiers)

Start:
220,433,884 bp from pter      End:
220,440,435 bp from pter
Size:
6,552 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: INHA_HUMAN, P05111 (See protein sequence)
Recommended Name: Inhibin alpha chain precursor  
Size: 366 amino acids; 39670 Da
Subunit: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a
dimer of alpha and beta-B
Secondary accessions: A8K8H5

Explore the universe of human proteins at neXtProt for INHA: NX_P05111

Explore proteomics data for INHA at MOPED

Post-translational modifications: 

  • Proteolytic processing yields a number of bioactive forms. The 20/23 kDa forms consist solely of the mature alpha
    chain, the 26/29 kDa forms consist of the most N-terminal propeptide linked through a disulfide bond to the
    mature alpha chain, the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either
    mono- or diglycosylated, causing the mass difference1
  • Glycosylation2 at Asn146, Asn268, Asn302
  • Modification sites at PhosphoSitePlus

  • See INHA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002182.1  
    ENSEMBL proteins: 
     ENSP00000243786  
    Reactome Protein details: P05111

    INHA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for INHA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for INHA
    GenScript Custom Purified and Recombinant Proteins Services for INHA
    Novus Biologicals INHA Proteins
    Novus Biologicals INHA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for INHA
    Cloud-Clone Corp. Proteins for INHA

    INHA Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for INHA
    OriGene Custom Antibody Services for INHA
    Novus Biologicals INHA Antibodies
    Abcam antibodies for INHA
    Cloud-Clone Corp. Antibodies for INHA
    ThermoFisher Antibodies for INHA
    LSBio Antibodies in human, mouse, rat for INHA

    INHA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for INHA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for INHA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INHA
    Cloud-Clone Corp. CLIAs for INHA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR002405 Inhibin_asu
     IPR017175 Inhibin_asu_subgr
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P05111

    ProtoNet protein and cluster: P05111

    2 Blocks protein domains:
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002405 Inhibin alpha chain signature


    UniProtKB/Swiss-Prot: INHA_HUMAN, P05111
    Similarity: Belongs to the TGF-beta family


    INHA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INHA_HUMAN, P05111
    Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
    gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and
    pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid
    differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on
    their subunit composition. Inhibins appear to oppose the functions of activins

         Genatlas biochemistry entry for INHA:
    inhibin,alpha subunit,18kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,to form inhibitin A or B
    respectively,inhibitors of FSH secretion,homodimerizing to form activing A stimulator of FSH secretion and
    involved in embryonic axis development or heterodimerizing with INHBB or INHA to form activin AB or inhibitin
    B,respectively

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI9032295
    GO:0005125cytokine activity TAS12456957
    GO:0005179hormone activity TAS12456957
    GO:0005515contributes to protein binding IPI10746731
    GO:0008083growth factor activity TAS12324653
         
    INHA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for INHA:
     Decreased cell number and incr 

         13 MGI mutant phenotypes (inferred from 1 allele(MGI details for Inha):
     cardiovascular system  digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  normal 
     reproductive system  skeleton  tumorigenesis 

    INHA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Inhatm1Bay for INHA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INHA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INHA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INHA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INHA

    miRNA
    Products:
        
    miRTarBase miRNAs that target INHA:
    hsa-mir-26b-5p (MIRT029233)

    Block miRNA regulation of human, mouse, rat INHA using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate INHA
    SwitchGear 3'UTR luciferase reporter plasmidINHA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INHA
    Predesigned siRNA for gene silencing in human, mouse, rat INHA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for INHA

    Clone
    Products:
         
    OriGene clones in human, mouse for INHA (see all 6)
    OriGene ORF clones in mouse, rat for INHA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INHA (NM_002191)
    Sino Biological Human cDNA Clone for INHA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INHA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INHA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for INHA
    Browse ESI BIO Cell Lines and PureStem Progenitors for INHA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INHA_HUMAN, P05111: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    cytoskeleton2
    nucleus2
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001750photoreceptor outer segment IEA--
    GO:0001917photoreceptor inner segment IEA--
    GO:0005576extracellular region TAS12456957
    GO:0005615extracellular space ----
    GO:0034673inhibin-betaglycan-ActRII complex IDA10746731

    INHA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for INHA About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Peptide hormone biosynthesis0.00
    Glycoprotein hormones0.00
    2Packaging Of Telomere Ends
    Signal transduction Activin A signaling regulation0.40
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4TGF-beta Signaling Pathway (sino)
    TGF-beta Signaling Pathway
    5Ovarian Infertility Genes
    Ovarian Infertility Genes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for INHA
        Signal transduction Activin A signaling regulation

    1 BioSystems Pathway for INHA
        Ovarian Infertility Genes

    1 Sino Biological Pathway for INHA
        TGF-beta Signaling Pathway

    1 Reactome Pathway for INHA
        Glycoprotein hormones



    INHA for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including INHA (see all 8): 
              Growth Factors in human mouse rat
              Cell Cycle in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Common Cytokines in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for INHA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for INHA (P051113 ENSP000002437864) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FSTP198833, ENSP000002567594I2D: score=1 STRING: ENSP00000256759
    TGFBR3Q031673, ENSP000002123554I2D: score=1 STRING: ENSP00000212355
    ACVR2AP270373, ENSP000002414164I2D: score=1 STRING: ENSP00000241416
    INHBAP084763, ENSP000002422084I2D: score=1 STRING: ENSP00000242208
    INHBBP095293, ENSP000002952284I2D: score=1 STRING: ENSP00000295228
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS10865214
    GO:0001541ovarian follicle development NAS9166111
    GO:0007050cell cycle arrest TAS12456957
    GO:0007165signal transduction TAS3267209
    GO:0007166cell surface receptor signaling pathway TAS12456957

    INHA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INHA

    Selected Novoseek inferred chemical compound relationships for INHA gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    isoniazid 89 119 15854436 (5), 12543676 (4), 14974741 (3), 7599116 (3) (see all 74)
    manganese(iii) pyrophosphate 80.4 1 11948876 (1)
    rifampicin 77.5 48 19893355 (3), 18560033 (2), 19172878 (2), 17897230 (2) (see all 30)
    ethionamide 76.1 10 19861006 (3), 7599116 (2), 14638486 (1), 19486070 (1) (see all 6)
    progesterone 61.5 51 8080927 (6), 12783698 (3), 16580171 (3), 16831355 (3) (see all 24)
    ethambutol 60.1 3 9494673 (1), 16870753 (1), 17360809 (1)
    streptomycin 57.1 6 9494673 (1), 11601331 (1), 16249627 (1), 11796356 (1)
    ribonucleic acid 55.8 7 8886632 (2), 1955539 (2), 1892206 (1), 11710435 (1) (see all 5)
    pyrazinamide 49.5 2 9494673 (1), 17360809 (1)
    testosterone 46.3 15 2307118 (4), 7608253 (2), 10569979 (1), 16429274 (1) (see all 11)



    INHA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for INHA gene: 
    NM_002191.3  

    Unigene Cluster for INHA:

    Inhibin, alpha
    Hs.407506  [show with all ESTs]
    Unigene Representative Sequence: BC039076
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489456 ENST00000243786(uc002vmk.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat INHA using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidINHA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat INHA
    Clone
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    OriGene clones in human, mouse for INHA (see all 6)
    OriGene ORF clones in mouse, rat for INHA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INHA (NM_002191)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INHA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INHA
    Primer
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    OriGene qPCR primer pairs and template standards for INHA
    OriGene qSTAR qPCR primer pairs in human, mouse for INHA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INHA
      QuantiTect SYBR Green Assays in human, mouse, rat INHA
      QuantiFast Probe-based Assays in human, mouse, rat INHA

    Additional mRNA sequence: 

    BC006391.2 BC039076.1 BT006954.1 M13144.1 M13981.1 

    5 DOTS entries:

    DT.411686  DT.97823930  DT.97824402  DT.101961551  DT.91819820 

    Selected AceView cDNA sequences (see all 55):

    AW235196 BQ013783 BT006954 AI919290 CR617999 NM_002191 BC006391 M13981 
    AU155550 BC039076 BE552259 CA487713 BM670529 AI351176 BI520936 AI807888 
    AU134634 AA936078 M13144 BM546385 BM906837 BF312530 T29423 AI148801 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INHA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGTTGTGG
    INHA Expression
    About this image


    INHA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             XY Germ Cells Testis Cord
             Seminiferous Tubules
     
     Gonad
             XY Germ Cells Testis Cord
     
     Eye (Sensory Organs)
             Mature Rod Bipolar Cells Inner Nuclear Layer
     
     Ovary (Reproductive System)
             Ovary Interstitium
     
     Neurons
             Mature Rod Bipolar Cells Inner Nuclear Layer
    INHA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INHA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.407506

    UniProtKB/Swiss-Prot: INHA_HUMAN, P05111
    Tissue specificity: Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed
    in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and
    the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in
    hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic
    hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only
    circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female

        Pathway & Disease-focused RT2 Profiler PCR Arrays including INHA (see all 8): 
              Growth Factors in human mouse rat
              Cell Cycle in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Common Cytokines in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for INHA
    OriGene qSTAR qPCR primer pairs in human, mouse for INHA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INHA
    QuantiTect SYBR Green Assays in human, mouse, rat INHA
    QuantiFast Probe-based Assays in human, mouse, rat INHA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for INHA gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inha1 , 5 inhibin alpha1, 5 82.61(n)1
    80.69(a)1
      1 (39.16 cM)5
    163221  NM_010564.41  NP_034694.31 
     755070775 
    chicken
    (Gallus gallus)
    Aves INHA1 inhibin, alpha 63.77(n)
    56.59(a)
      424197  NM_001031257.1  NP_001026428.1 
    lizard
    (Anolis carolinensis)
    Reptilia INHA6
    inhibin, alpha
    48(a)
    1 ↔ 1
    1(94516871-94523439)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia inha1 inhibin, alpha 57.25(n)
    50.32(a)
      613114  NM_001032351.1  NP_001027522.1 
    zebrafish
    (Danio rerio)
    Actinopterygii inha1 inhibin, alpha 49.9(n)
    38.68(a)
      570520  NM_001045204.1  NP_001038669.1 


    ENSEMBL Gene Tree for INHA (if available)
    TreeFam Gene Tree for INHA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INHA gene
    5 SIMAP similar genes for INHA using alignment to 2 protein entries:     INHA_HUMAN (see all proteins):
    BMP2    BMP3    GDF5    BMP7    NODAL

    INHA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INHA (see all 105)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355522601,2
    C--219818770(+) TTTTT-/G/T/TT
            
    GGTGT
    1 -- int11NA 2
    rs113420371,2
    C,F--220438310(+) TCTTC-/T/TT  
            
    TTTTT
    1 -- int1 trp32NA CSA 4
    rs1437336541,2
    C--220438310(+) TCTTC-/TTTTTTT 1 -- int10--------
    rs2009293011,2
    --220438311(+) TTCTT-/CTTTTT 1 -- int10--------
    rs118905881,2
    C,F,H--220438312(+) TTCTTC/TTTTTT 1 -- int1 trp33Minor allele frequency- T:0.25NA WA 8
    rs1834369671,2
    --220438419(+) AGGCCA/GGGCGC 1 -- int10--------
    rs1437092731,2
    --220438530(+) CTCTAA/CTAAAA 1 -- int10--------
    rs2018041371,2
    C--220438539(+) AATAC-/AAAAAA 1 -- int10--------
    rs1877601251,2
    --220438573(+) GCTACC/TCGGGA 1 -- int10--------
    rs1480451791,2
    --220438642(+) TGAGCC/TGAGAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for INHA (220433884 - 220440435 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for INHA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508887CNV Insertion20534489
    dgv4438n71CNV Loss21882294
    nsv875876CNV Loss21882294
    nsv834545CNV Loss17160897

    Human Gene Mutation Database (HGMD): INHA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INHA
    DNA2.0 Custom Variant and Variant Library Synthesis for INHA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147380    OMIM disorders: --

    Selected diseases for INHA (see all 95):    
    About MalaCards
    sertoli cell tumor    pleomorphic liposarcoma    mixed epithelial stromal tumour    invasive mole
    epithelioid trophoblastic tumor    parovarian cyst    ovarian small cell carcinoma    fallopian tube adenocarcinoma
    multidrug-resistant tuberculosis    peutz-jeghers syndrome    sex cord-gonadal stromal tumor    sertoli-leydig cell tumor
    granular cell tumor    hemangioblastoma    conn's syndrome    leydig cell tumor
    adenofibroma    preterm premature rupture of the membranes    gynecomastia    dysgerminoma

    9 diseases from the University of Copenhagen DISEASES database for INHA:
    Epithelioid trophoblastic tumor     Sex cord-gonadal stromal tumor     Premature ovarian failure     Parovarian cyst
    Sertoli cell tumor     Leydig cell tumor     Granular cell tumor     Fallopian tube adenocarcinoma
    Testicular cancer

    INHA for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for INHA gene (see all 80)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sex cord-stromal tumor 87.5 19 11192074 (3), 10747314 (2), 15256111 (2), 15381902 (1) (see all 11)
    granulosa cell tumor 86.6 20 17609358 (4), 9190962 (3), 10843483 (3), 19115695 (2) (see all 12)
    sertoli cell tumor 84.3 5 19255517 (1), 15363041 (1), 11971979 (1)
    sertoli-leydig cell tumor 82.6 3 9475192 (1), 20158943 (1), 12502966 (1)
    trophoblastic tumor 82.5 3 11603223 (2), 10202672 (1)
    tuberculosis 76.1 146 15854436 (4), 11802940 (4), 8684371 (3), 20200152 (3) (see all 85)
    trophoblastic tumor placental site 75 3 11603223 (2), 10202672 (1)
    thecoma 72.4 1 20198651 (1)
    adenoma adrenocortical 70 12 12910679 (4), 11556749 (2), 15256108 (1), 15970011 (1) (see all 6)
    stromal tumors 69.3 5 15059165 (3), 11192073 (1)

    Genetic Association Database (GAD): INHA
    Human Genome Epidemiology (HuGE) Navigator: INHA (35 documents)
    Tumor Gene Database (TGDB): INHA

    Export disorders for INHA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INHA gene, integrated from 10 sources (see all 515):
    (articles sorted by number of sources associating them with INHA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Investigating the association between inhibin alpha gene promoter polymorphisms and premature ovarian failure. (PubMed id 18249384)1, 4, 9 Woad K.J....Shelling A.N. (Fertil. Steril. 2009)
    2. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PubMed id 18413775)1, 4, 9 Purdue M.P....McGlynn K.A. (Cancer Res. 2008)
    3. The 769G&gt;A variant of the inhibin-alpha gene in Korean patients with preeclampsia. (PubMed id 18852530)1, 4, 9 Kim S.Y....Ryu H.M. (J. Endocrinol. Invest. 2008)
    4. INHA promoter polymorphisms are associated with premature ovarian failure. (PubMed id 16390856)1, 4, 9 Harris S.E....Shelling A.N. (Mol. Hum. Reprod. 2005)
    5. Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer. (PubMed id 9506758)1, 2, 9 Mellor S.L....Risbridger G.P. (J. Clin. Endocrinol. Metab. 1998)
    6. Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage. (PubMed id 20716560)1, 4 Hanna C.W....Robinson W.P. (Hum. Reprod. 2010)
    7. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    8. Inhibin and premature ovarian failure. (PubMed id 19752047)1, 4 Chand A.L....Shelling A.N. (Hum. Reprod. Update 2010)
    9. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (Hum. Mol. Genet. 2010)
    10. Mutational analysis of inhibin alpha gene revealed three novel variations in Indian women with premature ovarian failure. (PubMed id 19324345)1, 4 Prakash G.J....Sujatha M. (Fertil. Steril. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3623 HGNC: 6065 AceView: INHA Ensembl:ENSG00000123999 euGenes: HUgn3623
    ECgene: INHA H-InvDB: INHA

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for INHA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for INHA Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Inhibin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INHA gene:
    Search GeneIP for patents involving INHA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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