External Ids for INHA Gene
Previous GeneCards Identifiers for INHA Gene
This gene encodes a member of the TGF-beta superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mice in which a similar gene has been ablated exhibit sex cord-stromal tumors and symptoms that mimic the human cancer cachexia syndrome. [provided by RefSeq, Jan 2016]
GeneCards Summary for INHA Gene
INHA (Inhibin Alpha) is a Protein Coding gene. Diseases associated with INHA include Sex Cord-Gonadal Stromal Tumor and Sertoli Cell Tumor. Among its related pathways are Ovarian Infertility Genes and Peptide hormone metabolism. GO annotations related to this gene include protein heterodimerization activity and cytokine activity.
UniProtKB/Swiss-Prot for INHA Gene
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.