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Aliases for ING5 Gene

Aliases for ING5 Gene

  • Inhibitor Of Growth Family Member 5 2 3 5
  • P28ING5 3 4
  • Inhibitor Of Growth Protein 5 3

External Ids for ING5 Gene

Previous GeneCards Identifiers for ING5 Gene

  • GC02M238853
  • GC02M239540
  • GC02P242661
  • GC02P242962
  • GC02P242361
  • GC02P242291
  • GC02P234396
  • GC02P242641

Summaries for ING5 Gene

Entrez Gene Summary for ING5 Gene

  • This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]

GeneCards Summary for ING5 Gene

ING5 (Inhibitor Of Growth Family Member 5) is a Protein Coding gene. Among its related pathways are Regulation of TP53 Activity and Gene Expression. GO annotations related to this gene include chromatin binding and methylated histone binding. An important paralog of this gene is ING4.

UniProtKB/Swiss-Prot for ING5 Gene

  • Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator.

Gene Wiki entry for ING5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ING5 Gene

Genomics for ING5 Gene

Regulatory Elements for ING5 Gene

Enhancers for ING5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G241700 1.1 ENCODE 32.2 +14.9 14939 3.0 HDGF CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143 ING5 ENSG00000235351 ATG4B ENSG00000223374 GC02M241683 PIR47998
GH02G241685 1.1 ENCODE 30.2 +0.1 83 3.1 HNRNPUL1 PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000235351 ING5 ENSG00000215692 D2HGDH RTP5 ENSG00000234793 ATG4B GC02M241683
GH02G241664 1.1 Ensembl ENCODE 23.3 -21.4 -21370 2.1 PKNOX1 ARID4B SIN3A RAD21 ZEB1 GLIS2 ZNF366 SCRT2 FOS KDM4B ING5 ATG4B D2HGDH ENSG00000234793 DTYMK GC02M241661
GH02G241678 0.9 Ensembl ENCODE 23.1 -6.1 -6064 4.3 JUN BHLHE40 SIN3A ZNF121 ZFHX2 JUND POLR2A ZNF341 FOS MAFK ING5 ATG4B STK25 ENSG00000235351 BOK LINC01238 D2HGDH DTYMK GC02M241661
GH02G241616 1.2 ENCODE dbSUPER 16.1 -68.1 -68079 4.1 HDGF PKNOX1 GLI4 YY1 ETS1 ZNF143 FOS SP3 YY2 TSHZ1 SNED1 ENSG00000223374 ENSG00000235351 BOK ING5 DTYMK LOC100422094 PASK PPP1R7 FARP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ING5 on UCSC Golden Path with GeneCards custom track

Promoters for ING5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000133313 15 2201 HNRNPUL1 PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for ING5 Gene

Chromosome:
2
Start:
241,687,085 bp from pter
End:
241,729,481 bp from pter
Size:
42,397 bases
Orientation:
Plus strand

Genomic View for ING5 Gene

Genes around ING5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ING5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ING5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ING5 Gene

Proteins for ING5 Gene

  • Protein details for ING5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYH8-ING5_HUMAN
    Recommended name:
    Inhibitor of growth protein 5
    Protein Accession:
    Q8WYH8
    Secondary Accessions:
    • A8K1P3
    • Q53NU6
    • Q57Z54
    • Q9BS30

    Protein attributes for ING5 Gene

    Size:
    240 amino acids
    Molecular mass:
    27751 Da
    Quaternary structure:
    • Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with EP300 and TP53.

    Three dimensional structures from OCA and Proteopedia for ING5 Gene

    Alternative splice isoforms for ING5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ING5 Gene

Post-translational modifications for ING5 Gene

  • Ubiquitination at posLast=6767
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ING5 Gene

Domains & Families for ING5 Gene

Gene Families for ING5 Gene

Suggested Antigen Peptide Sequences for ING5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WYH8

UniProtKB/Swiss-Prot:

ING5_HUMAN :
  • The PHD-type zinc finger mediates the binding to H3K4me3.
  • Belongs to the ING family.
Domain:
  • The PHD-type zinc finger mediates the binding to H3K4me3.
Family:
  • Belongs to the ING family.
genes like me logo Genes that share domains with ING5: view

Function for ING5 Gene

Molecular function for ING5 Gene

UniProtKB/Swiss-Prot Function:
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator.

Gene Ontology (GO) - Molecular Function for ING5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12750254
GO:0008270 zinc ion binding IEA --
GO:0035064 methylated histone binding IDA 16728974
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ING5: view
genes like me logo Genes that share phenotypes with ING5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ING5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ING5 Gene

Localization for ING5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ING5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ING5 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
golgi apparatus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ING5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18794358
GO:0005654 nucleoplasm TAS --
GO:0070776 MOZ/MORF histone acetyltransferase complex IDA,IEA 16387653
genes like me logo Genes that share ontologies with ING5: view

Pathways & Interactions for ING5 Gene

genes like me logo Genes that share pathways with ING5: view

Gene Ontology (GO) - Biological Process for ING5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IDA 16387653
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006473 protein acetylation IDA 12750254
GO:0008285 negative regulation of cell proliferation IEA,IGI 21750715
genes like me logo Genes that share ontologies with ING5: view

No data available for SIGNOR curated interactions for ING5 Gene

Drugs & Compounds for ING5 Gene

No Compound Related Data Available

Transcripts for ING5 Gene

Unigene Clusters for ING5 Gene

Inhibitor of growth family, member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ING5

Alternative Splicing Database (ASD) splice patterns (SP) for ING5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5:

Relevant External Links for ING5 Gene

GeneLoc Exon Structure for
ING5
ECgene alternative splicing isoforms for
ING5

Expression for ING5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ING5 Gene

Protein differential expression in normal tissues from HIPED for ING5 Gene

This gene is overexpressed in NK cells (27.7), Liver (11.5), Monocytes (10.3), and Breast (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ING5 Gene



Protein tissue co-expression partners for ING5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ING5 Gene:

ING5

SOURCE GeneReport for Unigene cluster for ING5 Gene:

Hs.529172

Evidence on tissue expression from TISSUES for ING5 Gene

  • Nervous system(4.4)
  • Skin(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with ING5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ING5 Gene

Orthologs for ING5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ING5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ING5 34 35
  • 99.44 (n)
oppossum
(Monodelphis domestica)
Mammalia ING5 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ING5 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ING5 34 35
  • 90.28 (n)
cow
(Bos Taurus)
Mammalia ING5 34 35
  • 89.03 (n)
mouse
(Mus musculus)
Mammalia Ing5 34 16 35
  • 88.47 (n)
chicken
(Gallus gallus)
Aves ING5 34 35
  • 84.07 (n)
lizard
(Anolis carolinensis)
Reptilia ING5 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ing5 34
  • 73.73 (n)
zebrafish
(Danio rerio)
Actinopterygii ing5a 34 35
  • 71.69 (n)
ing5b 35
  • 67 (a)
OneToMany
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG9293 35
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO23 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToMany
Species where no ortholog for ING5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ING5 Gene

ENSEMBL:
Gene Tree for ING5 (if available)
TreeFam:
Gene Tree for ING5 (if available)

Paralogs for ING5 Gene

Paralogs for ING5 Gene

(3) SIMAP similar genes for ING5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ING5: view

Variants for ING5 Gene

Sequence variations from dbSNP and Humsavar for ING5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000005372 -- 241,697,563(+) ATTGC(C/T)GAGTG intron-variant
rs1000182821 -- 241,723,679(+) CGGGG(C/T)ATGGA intron-variant, nc-transcript-variant
rs1000242398 -- 241,688,233(+) CACTC(C/T)TACCT intron-variant, upstream-variant-2KB
rs1000242627 -- 241,720,308(+) TGGTG(C/G)CAGGC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000279918 -- 241,723,687(+) GGATC(C/T)GGGGC intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ING5 Gene

Variant ID Type Subtype PubMed ID
dgv165e55 CNV loss 17911159
nsv1002941 CNV gain 25217958
nsv1006733 CNV gain 25217958
nsv1073033 CNV deletion 25765185
nsv1143973 CNV deletion 24896259
nsv508901 CNV insertion 20534489
nsv584974 CNV gain 21841781
nsv584975 CNV loss 21841781
nsv997984 CNV gain 25217958

Variation tolerance for ING5 Gene

Residual Variation Intolerance Score: 27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ING5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ING5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ING5 Gene

Disorders for ING5 Gene

Relevant External Links for ING5

Genetic Association Database (GAD)
ING5
Human Genome Epidemiology (HuGE) Navigator
ING5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ING5

No disorders were found for ING5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ING5 Gene

Publications for ING5 Gene

  1. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. (PMID: 12750254) Shiseki M. … Harris C.C. (Cancer Res. 2003) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide. (PMID: 18623064) Champagne K.S. … Kutateladze T.G. (Proteins 2008) 3 4 64
  4. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. (PMID: 18794358) Ullah M. … Yang X.-J. (Mol. Cell. Biol. 2008) 3 4 64
  5. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PMID: 16387653) Doyon Y. … Cote J. (Mol. Cell 2006) 3 4 64

Products for ING5 Gene

  • Addgene plasmids for ING5

Sources for ING5 Gene

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