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Aliases for ING5 Gene

Aliases for ING5 Gene

  • Inhibitor Of Growth Family, Member 5 2 3
  • P28ING5 3 4
  • Inhibitor Of Growth Protein 5 3

External Ids for ING5 Gene

Previous GeneCards Identifiers for ING5 Gene

  • GC02M238853
  • GC02M239540
  • GC02P242661
  • GC02P242962
  • GC02P242361
  • GC02P242291
  • GC02P234396
  • GC02P242641

Summaries for ING5 Gene

Entrez Gene Summary for ING5 Gene

  • The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for ING5 Gene

ING5 (Inhibitor Of Growth Family, Member 5) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include chromatin binding and methylated histone binding. An important paralog of this gene is ING4.

UniProtKB/Swiss-Prot for ING5 Gene

  • Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator.

Gene Wiki entry for ING5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ING5 Gene

Genomics for ING5 Gene

Regulatory Elements for ING5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ING5 Gene

Start:
241,702,035 bp from pter
End:
241,729,481 bp from pter
Size:
27,447 bases
Orientation:
Plus strand

Genomic View for ING5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ING5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ING5 Gene

Proteins for ING5 Gene

  • Protein details for ING5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYH8-ING5_HUMAN
    Recommended name:
    Inhibitor of growth protein 5
    Protein Accession:
    Q8WYH8
    Secondary Accessions:
    • A8K1P3
    • Q53NU6
    • Q57Z54
    • Q9BS30

    Protein attributes for ING5 Gene

    Size:
    240 amino acids
    Molecular mass:
    27751 Da
    Quaternary structure:
    • Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with EP300 and TP53.

    Three dimensional structures from OCA and Proteopedia for ING5 Gene

    Alternative splice isoforms for ING5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ING5 Gene

Proteomics data for ING5 Gene at MOPED

Post-translational modifications for ING5 Gene

  • Ubiquitination at Lys67
  • Modification sites at PhosphoSitePlus

Other Protein References for ING5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ING5 Gene

Domains for ING5 Gene

Gene Families for ING5 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

Suggested Antigen Peptide Sequences for ING5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WYH8

UniProtKB/Swiss-Prot:

ING5_HUMAN :
  • Q8WYH8
Domain:
  • The PHD-type zinc finger mediates the binding to H3K4me3.
Family:
  • Belongs to the ING family.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with ING5: view

Function for ING5 Gene

Molecular function for ING5 Gene

UniProtKB/Swiss-Prot Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator.

Gene Ontology (GO) - Molecular Function for ING5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 12750254
GO:0008270 zinc ion binding IEA --
GO:0035064 methylated histone binding IDA 16728974
genes like me logo Genes that share ontologies with ING5: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ING5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ING5 Gene

Localization for ING5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ING5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ING5 Gene COMPARTMENTS Subcellular localization image for ING5 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ING5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18794358
GO:0005654 nucleoplasm TAS --
GO:0070776 MOZ/MORF histone acetyltransferase complex IDA 16387653
genes like me logo Genes that share ontologies with ING5: view

Pathways for ING5 Gene

genes like me logo Genes that share pathways with ING5: view

Pathways by source for ING5 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ING5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IDA 16387653
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006473 protein acetylation IDA 12750254
GO:0008285 negative regulation of cell proliferation IGI 21750715
genes like me logo Genes that share ontologies with ING5: view

Transcripts for ING5 Gene

Unigene Clusters for ING5 Gene

Inhibitor of growth family, member 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ING5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ING5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5:

Relevant External Links for ING5 Gene

GeneLoc Exon Structure for
ING5
ECgene alternative splicing isoforms for
ING5

Expression for ING5 Gene

mRNA expression in normal human tissues for ING5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ING5 Gene

SOURCE GeneReport for Unigene cluster for ING5 Gene Hs.529172

genes like me logo Genes that share expressions with ING5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ING5 Gene

Orthologs for ING5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ING5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ING5 35
  • 99.44 (n)
  • 100 (a)
ING5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ING5 35
  • 89.03 (n)
  • 96.67 (a)
ING5 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ING5 35
  • 90.28 (n)
  • 98.33 (a)
ING5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ing5 35
  • 88.47 (n)
  • 94.58 (a)
Ing5 16
Ing5 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ING5 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ING5 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves ING5 35
  • 84.07 (n)
  • 90.71 (a)
ING5 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ING5 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ing5 35
  • 73.73 (n)
  • 83.47 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ing5a 35
  • 71.69 (n)
  • 77.41 (a)
ing5a 36
  • 77 (a)
OneToMany
ing5b 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9293 36
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO23 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for ING5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ING5 Gene

ENSEMBL:
Gene Tree for ING5 (if available)
TreeFam:
Gene Tree for ING5 (if available)

Paralogs for ING5 Gene

Paralogs for ING5 Gene

Selected SIMAP similar genes for ING5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ING5: view

Variants for ING5 Gene

Sequence variations from dbSNP and Humsavar for ING5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs10047 -- 241,725,564(+) TCGGA(C/T)GGGCC utr-variant-3-prime, nc-transcript-variant
rs12048 -- 241,725,593(+) TTCCC(C/T)GGAGG utr-variant-3-prime, nc-transcript-variant
rs12903 -- 241,729,120(-) ATTTA(A/G)GAAAA utr-variant-3-prime, nc-transcript-variant
rs1133811 -- 241,725,905(-) GGGCC(C/T)GGGAA utr-variant-3-prime, nc-transcript-variant
rs3887696 -- 241,705,436(-) TGGGC(A/G)ACAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ING5 Gene

Variant ID Type Subtype PubMed ID
nsv876226 CNV Loss 21882294
dgv4493n71 CNV Loss 21882294
dgv4494n71 CNV Loss 21882294
dgv4495n71 CNV Loss 21882294
dgv165e55 CNV Loss 17911159
dgv4496n71 CNV Loss 21882294
nsv508901 CNV Insertion 20534489
nsv876242 CNV Loss 21882294
dgv4497n71 CNV Loss 21882294
dgv4498n71 CNV Loss 21882294
nsv876249 CNV Loss 21882294
nsv876250 CNV Gain 21882294
nsv876253 CNV Loss 21882294

Relevant External Links for ING5 Gene

HapMap Linkage Disequilibrium report
ING5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ING5 Gene

Disorders for ING5 Gene

Relevant External Links for ING5

Genetic Association Database (GAD)
ING5
Human Genome Epidemiology (HuGE) Navigator
ING5
genes like me logo Genes that share disorders with ING5: view

No data available for UniProtKB/Swiss-Prot for ING5 Gene

Publications for ING5 Gene

  1. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. (PMID: 12750254) Shiseki M. … Harris C.C. (Cancer Res. 2003) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PMID: 16387653) Doyon Y. … Cote J. (Mol. Cell 2006) 3 4
  4. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. (PMID: 16728974) Shi X. … Gozani O. (Nature 2006) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for ING5 Gene

  • Addgene plasmids for ING5

Sources for ING5 Gene

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