External Ids for ING5 Gene
Previous GeneCards Identifiers for ING5 Gene
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq, Jul 2008]
GeneCards Summary for ING5 Gene
ING5 (Inhibitor Of Growth Family, Member 5) is a Protein Coding gene. Among its related pathways are Chromatin organization. GO annotations related to this gene include chromatin binding and methylated histone binding. An important paralog of this gene is ING4.
UniProtKB/Swiss-Prot for ING5 Gene
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator.