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ING5 Gene

protein-coding   GIFtS: 57
GCID: GC02P242641

Inhibitor Of Growth Family, Member 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inhibitor Of Growth Family, Member 51 2
p28ING52 3
Inhibitor Of Growth Protein 52

External Ids:    HGNC: 194211   Entrez Gene: 842892   Ensembl: ENSG000001683957   OMIM: 6085255   UniProtKB: Q8WYH83   

Export aliases for ING5 gene to outside databases

Previous GC identifers: GC02M238853 GC02M239540 GC02P242661 GC02P242962 GC02P242361 GC02P242291 GC02P234396


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ING5 Gene:
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53,
inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in
proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone
acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. (provided by RefSeq,
Jul 2008)

GeneCards Summary for ING5 Gene:
ING5 (inhibitor of growth family, member 5) is a protein-coding gene. Diseases associated with ING5 include gastric diffuse adenocarcinoma, and oral squamous cell carcinoma. GO annotations related to this gene include chromatin binding and methylated histone residue binding. An important paralog of this gene is ING2.

UniProtKB/Swiss-Prot: ING5_HUMAN, Q8WYH8
Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced
activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the
MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate
DNA replication and may function as a transcriptional coactivator

Gene Wiki entry for ING5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ING5 gene promoter:
         NF-1   NF-1/L   GATA-3   Lmo2   Nkx2-5   Nkx5-1   AREB6   PPAR-gamma1   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ING5 promoter sequence
   Search Chromatin IP Primers for ING5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ING5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

ING5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ING5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P242641:  view genomic region     (about GC identifiers)

Start:
242,641,450 bp from pter      End:
242,668,896 bp from pter
Size:
27,447 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ING5_HUMAN, Q8WYH8 (See protein sequence)
Recommended Name: Inhibitor of growth protein 5  
Size: 240 amino acids; 27751 Da
Subunit: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the HBO1 complex composed at
least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Component of the MOZ/MORF complex
composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with EP300 and
TP53
1 PDB 3D structure from and Proteopedia for ING5:
3C6W (3D)    
Secondary accessions: A8K1P3 Q53NU6 Q57Z54 Q9BS30
Alternative splicing: 2 isoforms:  Q8WYH8-1   Q8WYH8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ING5: NX_Q8WYH8

Explore proteomics data for ING5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys67
  • Modification sites at PhosphoSitePlus

  • See ING5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115705.2  
    ENSEMBL proteins: 
     ENSP00000322142   ENSP00000385937   ENSP00000416878  
    Reactome Protein details: Q8WYH8

    ING5 Human Recombinant Protein Products:

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    Novus Biologicals ING5 Lysates
    Sino Biological Recombinant Protein for ING5
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ING5

    ING5 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for ING5

    ING5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ING5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ING5
    Cloud-Clone Corp. CLIAs for ING5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 8):
     IPR028638 ING5
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR028651 ING_fam
     IPR024610 ING_N

    Graphical View of Domain Structure for InterPro Entry Q8WYH8

    ProtoNet protein and cluster: Q8WYH8

    1 Blocks protein domain: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: ING5_HUMAN, Q8WYH8
    Domain: The PHD-type zinc finger mediates the binding to H3K4me3
    Similarity: Belongs to the ING family
    Similarity: Contains 1 PHD-type zinc finger


    ING5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ING5_HUMAN, Q8WYH8
    Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced
    activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the
    MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate
    DNA replication and may function as a transcriptional coactivator

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI12750254
    GO:0008270zinc ion binding IEA--
    GO:0035064methylated histone residue binding IDA16728974
         
    ING5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ING5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ING5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ING5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ING5

    miRNA
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    Block miRNA regulation of human, mouse, rat ING5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ING5 (see all 56):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-548j hsa-miR-640 hsa-miR-193a-3p hsa-miR-379* hsa-miR-513a-5p hsa-miR-128
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ING5
    Predesigned siRNA for gene silencing in human, mouse, rat ING5

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for ING5 (see all 8)
    OriGene ORF clones in mouse, rat for ING5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ING5 (NM_032329)
    Sino Biological Human cDNA Clone for ING5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING5

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ING5_HUMAN, Q8WYH8: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18794358
    GO:0005654nucleoplasm TAS--
    GO:0070776MOZ/MORF histone acetyltransferase complex IDA16387653

    ING5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ING5 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for ING5
        HATs acetylate histones



    ING5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ING5: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ING5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ING5 (Q8WYH82, 3 ENSP000003221424) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TADA3O755282, 3, ENSP000003076844MINT-3979398 I2D: score=4 STRING: ENSP00000307684
    KIAA1377Q9P2H02, 3, ENSP000002634684MINT-3981169 I2D: score=3 STRING: ENSP00000263468
    VIMP086702, 3, ENSP000002242374MINT-3980438 I2D: score=3 STRING: ENSP00000224237
    APLP1P516932, 3, ENSP000002218914MINT-3979876 I2D: score=2 STRING: ENSP00000221891
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8201859 I2D: score=1 STRING: ENSP00000250416
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IDA16387653
    GO:0006325chromatin organization TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006473protein acetylation IDA12750254
    GO:0008285negative regulation of cell proliferation IGI--

    ING5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ING5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ING5 gene: 
    NM_032329.4  

    Unigene Cluster for ING5:

    Inhibitor of growth family, member 5
    Hs.529172  [show with all ESTs]
    Unigene Representative Sequence: NM_032329
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492488 ENST00000313552(uc002wcd.3) ENST00000482774 ENST00000493261
    ENST00000406941 ENST00000445620 ENST00000489509(uc021vzk.1) ENST00000484145
    ENST00000493578 ENST00000474238 ENST00000486061
    miRNA
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    Block miRNA regulation of human, mouse, rat ING5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ING5 (see all 56):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-548j hsa-miR-640 hsa-miR-193a-3p hsa-miR-379* hsa-miR-513a-5p hsa-miR-128
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ING5
    Predesigned siRNA for gene silencing in human, mouse, rat ING5
    Clone
    Products:
         
    OriGene clones in human, mouse for ING5 (see all 8)
    OriGene ORF clones in mouse, rat for ING5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ING5 (NM_032329)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ING5
    OriGene qSTAR qPCR primer pairs in human, mouse for ING5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ING5
      QuantiTect SYBR Green Assays in human, mouse, rat ING5
      QuantiFast Probe-based Assays in human, mouse, rat ING5

    Additional mRNA sequence: 

    AF189286.1 AK074422.1 AK128322.1 AK289958.1 AK300790.1 AY203944.1 BC005370.1 BC039028.1 
    BC071899.1 

    10 DOTS entries:

    DT.109463  DT.95157863  DT.95097414  DT.95147505  DT.40267004  DT.40276527  DT.97772176  DT.100667978 
    DT.100744199  DT.95293497 

    Selected AceView cDNA sequences (see all 130):

    BQ677883 CK906086 AI868796 CB055130 AW195045 BQ675901 BU632347 AW135831 
    BU149727 CK906087 AA490608 BM127448 BQ771894 BI962551 AW818264 AI972491 
    AI422531 CA771128 AF189286 BE218301 BM055236 AI337313 BU185422 AI124772 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ING5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                            -     -     -     -                 -         
    SP2:                                            -     -     -     -                           
    SP3:                                            -                                             
    SP4:                                            -           -                                 
    SP5:                                                                                          


    ECgene alternative splicing isoforms for ING5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ING5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATAGATTA
    ING5 Expression
    About this image

    ING5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ING5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529172
        Pathway & Disease-focused RT2 Profiler PCR Array including ING5: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ING5
    OriGene qSTAR qPCR primer pairs in human, mouse for ING5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ING5
    QuantiTect SYBR Green Assays in human, mouse, rat ING5
    QuantiFast Probe-based Assays in human, mouse, rat ING5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ING5 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ing51 , 5 inhibitor of growth family, member 51, 5 88.47(n)1
    94.58(a)1
      1 (47.34 cM)5
    662621  NM_025454.21  NP_079730.11 
     938039655 
    chicken
    (Gallus gallus)
    Aves ING51 inhibitor of growth family, member 5 84.07(n)
    90.71(a)
      424852  NM_001031312.1  NP_001026483.1 
    lizard
    (Anolis carolinensis)
    Reptilia ING56
    inhibitor of growth family, member 5
    85(a)
    1 ↔ 1
    3(30571592-30587392)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA794009.12   -- 78.04(n)    CA794009.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY391432.12   -- 76.39(n)   386591  AY391432.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92936
    --
    48(a)
    1 → many
    2L(13385848-13387299)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO236
    Probable component of the Rpd3 histone deacetylase...
    20(a)
    1 → many
    XIV(441366-442358) YNL097C


    ENSEMBL Gene Tree for ING5 (if available)
    TreeFam Gene Tree for ING5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ING5 gene
    ING22  ING42  ING32  ING12  
    3 SIMAP similar genes for ING5 using alignment to 2 protein entries:     ING5_HUMAN (see all proteins):
    ING4    ING2    ING3

    ING5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ING5 (see all 690)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs797083351,2
    C--242639474(+) CTCACA/TGCAAC 1 -- us2k10--------
    rs794339531,2
    C--242639688(+) TGCCTG/CGGCCG 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs116958991,2
    C,H--242639842(+) gctggT/Aattac 1 -- us2k11Minor allele frequency- A:0.00NA 4
    rs1918678311,2
    --242639965(+) TCCCAA/GGCTCA 1 -- us2k10--------
    rs1839881511,2
    --242640032(+) TGCCCG/TGCTAG 1 -- us2k10--------
    rs1893980011,2
    --242640040(+) TAGTTG/TTTGTA 1 -- us2k10--------
    rs2002806721,2
    --242640043(+) TTTTG-/TATTATTA 1 -- cds10--------
    rs1460662011,2
    --242640044(+) TTTTGC/TATTAT 1 -- us2k10--------
    rs621913121,2
    --242640201(+) ACGCCA/CGGGTA 1 -- us2k10--------
    rs1809592071,2
    --242640300(+) CCTCCC/TAAAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ING5 (242641450 - 242668896 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ING5 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508901CNV Insertion20534489
    dgv4495n71CNV Loss21882294
    dgv4493n71CNV Loss21882294
    dgv4494n71CNV Loss21882294
    dgv4496n71CNV Loss21882294
    dgv4498n71CNV Loss21882294
    nsv876242CNV Loss21882294
    nsv876249CNV Loss21882294
    nsv876226CNV Loss21882294
    dgv4497n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608525    OMIM disorders: --

    6 diseases for ING5:    
    About MalaCards
    gastric diffuse adenocarcinoma    oral squamous cell carcinoma    huntington's disease    squamous cell carcinoma
    adenocarcinoma    malaria


    ING5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ING5
    Human Genome Epidemiology (HuGE) Navigator: ING5 (1 document)

    Export disorders for ING5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ING5 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with ING5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. (PubMed id 12750254)1, 2, 3, 9 Shiseki M....Harris C.C. (Cancer Res. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide. (PubMed id 18623064)1, 2 Champagne K.S.... Kutateladze T.G. (Proteins 2008)
    4. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. (PubMed id 18794358)1, 2 Ullah M....Yang X.-J. (Mol. Cell. Biol. 2008)
    5. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. (PubMed id 16728974)1, 2 Shi X.... Gozani O. (Nature 2006)
    6. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2 Doyon Y.... Cote J. (Mol. Cell 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84289 HGNC: 19421 AceView: LOC401047 Ensembl:ENSG00000168395 euGenes: HUgn84289
    ECgene: ING5 H-InvDB: ING5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ING5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ING5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ING5 gene:
    Search GeneIP for patents involving ING5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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