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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ING5 Gene

protein-coding   GIFtS: 54
GCID: GC02P242641

Inhibitor Of Growth Family, Member 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Inhibitor Of Growth Family, Member 51 2
p28ING52 3
Inhibitor Of Growth Protein 52

External Ids:    HGNC: 194211   Entrez Gene: 842892   Ensembl: ENSG000001683957   OMIM: 6085255   UniProtKB: Q8WYH83   

Export aliases for ING5 gene to outside databases

Previous GC identifers: GC02M238853 GC02M239540 GC02P242661 GC02P242962 GC02P242361 GC02P242291 GC02P234396


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ING5 Gene:
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53,
inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in
proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone
acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. (provided by RefSeq,
Jul 2008)

GeneCards Summary for ING5 Gene: 
ING5 (inhibitor of growth family, member 5) is a protein-coding gene. Diseases associated with ING5 include gastric diffuse adenocarcinoma, and oral squamous cell carcinoma. GO annotations related to this gene include methylated histone residue binding and zinc ion binding. An important paralog of this gene is ING2.

UniProtKB/Swiss-Prot: ING5_HUMAN, Q8WYH8
Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced
activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the
MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate
DNA replication and may function as a transcriptional coactivator

Gene Wiki entry for ING5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005416.13  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ING5 gene promoter:
         NF-1   NF-1/L   GATA-3   Lmo2   Nkx2-5   Nkx5-1   AREB6   PPAR-gamma1   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ING5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ING5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ING5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

ING5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ING5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P242641:  view genomic region     (about GC identifiers)

Start:
242,641,450 bp from pter      End:
242,668,896 bp from pter
Size:
27,447 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ING5_HUMAN, Q8WYH8 (See protein sequence)
Recommended Name: Inhibitor of growth protein 5  
Size: 240 amino acids; 27751 Da
Subunit: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the HBO1 complex composed at
least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16 and PHF17. Component of the MOZ/MORF complex
composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with EP300 and
TP53
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for ING5:
3C6W (3D)    
Secondary accessions: A8K1P3 Q53NU6 Q57Z54 Q9BS30
Alternative splicing: 2 isoforms:  Q8WYH8-1   Q8WYH8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ING5: NX_Q8WYH8

Explore proteomics data for ING5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WYH8

  • ING5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ING5 Protein Expression
    REFSEQ proteins: NP_115705.2  
    ENSEMBL proteins: 
     ENSP00000322142   ENSP00000385937   ENSP00000416878  

    Human Recombinant Protein Products for ING5: 
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    Novus Biologicals ING5 Lysates
    Sino Biological Recombinant Protein for ING5
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ING5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18794358
    GO:0070776MOZ/MORF histone acetyltransferase complex IDA16387653

    ING5 for ontologies           About GeneDecksing



    ING5 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for ING5 
    Cloud-Clone Corp. CLIAs for ING5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PHF: Zinc fingers, PHD-type

    5/6 InterPro protein domains (see all 6):
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR024610 ING_N
     IPR019786 Zinc_finger_PHD-type_CS
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q8WYH8

    ProtoNet protein and cluster: Q8WYH8

    1 Blocks protein domain: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: ING5_HUMAN, Q8WYH8
    Domain: The PHD-type zinc finger mediates the binding to H3K4me3
    Similarity: Belongs to the ING family
    Similarity: Contains 1 PHD-type zinc finger


    ING5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ING5_HUMAN, Q8WYH8
    Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced
    activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the
    MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate
    DNA replication and may function as a transcriptional coactivator

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI12750254
    GO:0008270zinc ion binding IEA--
    GO:0035064methylated histone residue binding IDA16728974
         
    ING5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ING5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ING5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ING5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ING5 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ING5
    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate ING5 (see all 56):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-548j hsa-miR-640 hsa-miR-193a-3p hsa-miR-379* hsa-miR-513a-5p hsa-miR-128
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: ING5 (NM_032329)
    Sino Biological Human cDNA Clone for ING5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING5
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                         Customized lentivirus expression plasmids for stable overexpression of ING5 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ING5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for ING5 (Q8WYH82, 3 ENSP000003221424) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TADA3O755282, 3, ENSP000003076844MINT-3979398 I2D: score=4 STRING: ENSP00000307684
    KIAA1377Q9P2H02, 3, ENSP000002634684MINT-3981169 I2D: score=3 STRING: ENSP00000263468
    VIMP086702, 3, ENSP000002242374MINT-3980438 I2D: score=3 STRING: ENSP00000224237
    APLP1P516932, 3, ENSP000002218914MINT-3979876 I2D: score=2 STRING: ENSP00000221891
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8201859 I2D: score=1 STRING: ENSP00000250416
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IDA16387653
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006473protein acetylation IDA12750254
    GO:0008285negative regulation of cell proliferation IGI--
    GO:0043065positive regulation of apoptotic process IGI--

    ING5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ING5

    Search CenterWatch for drugs/clinical trials and news about ING5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ING5 gene: 
    NM_032329.4  

    Unigene Cluster for ING5:

    Inhibitor of growth family, member 5
    Hs.529172  [show with all ESTs]
    Unigene Representative Sequence: NM_032329
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492488 ENST00000313552(uc002wcd.3) ENST00000482774 ENST00000493261
    ENST00000406941 ENST00000445620 ENST00000489509(uc021vzk.1) ENST00000484145
    ENST00000493578 ENST00000474238 ENST00000486061
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ING5
    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate ING5 (see all 56):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-548j hsa-miR-640 hsa-miR-193a-3p hsa-miR-379* hsa-miR-513a-5p hsa-miR-128
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ING5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ING5
    Clone
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    OriGene clones in human, mouse for ING5 (see all 9)
    OriGene ORF clones in mouse, rat for ING5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ING5 (NM_032329)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING5
    Sirion Biotech Customized lentivirus for stable overexpression of ING5 
                         Customized lentivirus expression plasmids for stable overexpression of ING5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ING5
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ING5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ING5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ING5

    Additional mRNA sequence: 

    AF189286.1 AK074422.1 AK128322.1 AK289958.1 AK300790.1 AY203944.1 BC005370.1 BC039028.1 
    BC071899.1 

    10 DOTS entries:

    DT.109463  DT.95157863  DT.95097414  DT.95147505  DT.40267004  DT.40276527  DT.97772176  DT.100667978 
    DT.100744199  DT.95293497 

    24/130 AceView cDNA sequences (see all 130):

    BQ678481 BU149727 AI422531 AA490608 H69731 BU509620 CA771128 AI675196 
    BU632347 BQ683118 BQ877416 BQ771894 CF529546 BQ677883 CA842795 BQ675901 
    BU629905 BM055236 CB055130 BI962551 BE218301 AA353456 CK906086 AW195045 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ING5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                            -     -     -     -                 -         
    SP2:                                            -     -     -     -                           
    SP3:                                            -                                             
    SP4:                                            -           -                                 
    SP5:                                                                                          


    ECgene alternative splicing isoforms for ING5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ING5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATAGATTA
    ING5 Expression
    About this image


    See ING5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ING5

    SOURCE GeneReport for Unigene cluster: Hs.529172
        SABiosciences Expression via Pathway-Focused PCR Array including ING5: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ING5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ING5 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ing51 , 5 inhibitor of growth family, member 51, 5 88.47(n)1
    94.58(a)1
      1 (47.34 cM)5
    662621  NM_025454.21  NP_079730.11 
     938039655 
    chicken
    (Gallus gallus)
    Aves ING51 inhibitor of growth family, member 5 84.07(n)
    90.71(a)
      424852  NM_001031312.1  NP_001026483.1 
    lizard
    (Anolis carolinensis)
    Reptilia ING56
    Uncharacterized protein
    85(a)
    1 ↔ 1
    3(30571592-30587392)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA794009.12   -- 78.04(n)    CA794009.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY391432.12   -- 76.39(n)   386591  AY391432.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92931 CG9293 61.23(n)
    59.41(a)
      34752  NM_165042.2  NP_723814.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YNG21 Yng2p 45.34(n)
    30.51(a)
      856490   NP_011958.1 


    ENSEMBL Gene Tree for ING5 (if available)
    TreeFam Gene Tree for ING5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ING5 gene
    ING22  ING42  ING32  ING12  
    4 SIMAP similar genes for ING5 using alignment to 2 protein entries:     ING5_HUMAN (see all proteins):
    ING4    ING2    ING3    ING2b

    ING5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/690 SNPs in ING5 are shown (see all 690)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs797083351,2
    C--242639474(+) CTCACA/TGCAAC 1 -- us2k10--------
    rs794339531,2
    C--242639688(+) TGCCTG/CGGCCG 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs116958991,2
    C,H--242639842(+) gctggT/Aattac 1 -- us2k11Minor allele frequency- A:0.00NA 4
    rs1918678311,2
    --242639965(+) TCCCAA/GGCTCA 1 -- us2k10--------
    rs1839881511,2
    --242640032(+) TGCCCG/TGCTAG 1 -- us2k10--------
    rs1893980011,2
    --242640040(+) TAGTTG/TTTGTA 1 -- us2k10--------
    rs2002806721,2
    --242640043(+) TTTTG-/TATTATTA 1 -- cds10--------
    rs1460662011,2
    --242640044(+) TTTTGC/TATTAT 1 -- us2k10--------
    rs621913121,2
    --242640201(+) ACGCCA/CGGGTA 1 -- us2k10--------
    rs1809592071,2
    --242640300(+) CCTCCC/TAAAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ING5 (242641450 - 242668896 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for ING5 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508901CNV Insertion20534489
    dgv4495n71CNV Loss21882294
    dgv4493n71CNV Loss21882294
    dgv4494n71CNV Loss21882294
    dgv4496n71CNV Loss21882294
    dgv4498n71CNV Loss21882294
    nsv876242CNV Loss21882294
    nsv876249CNV Loss21882294
    nsv876226CNV Loss21882294
    dgv4497n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608525    OMIM disorders: --

    4 diseases for ING5:    About MalaCards
    gastric diffuse adenocarcinoma    oral squamous cell carcinoma    squamous cell carcinoma    adenocarcinoma


    ING5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ING5
    Human Genome Epidemiology (HuGE) Navigator: ING5 (1 document)

    Export disorders for ING5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ING5 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with ING5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. (PubMed id 12750254)1, 2, 3, 9 Shiseki M....Harris C.C. (2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide. (PubMed id 18623064)1, 2 Champagne K.S....Kutateladze T.G. (2008)
    4. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. (PubMed id 18794358)1, 2 Ullah M....Yang X.-J. (2008)
    5. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. (PubMed id 16728974)1, 2 Shi X....Gozani O. (2006)
    6. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2 Doyon Y.... Cote J. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84289 HGNC: 19421 AceView: LOC401047 Ensembl:ENSG00000168395 euGenes: HUgn84289
    ECgene: ING5 H-InvDB: ING5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ING5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ING5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ING5 gene:
    Search GeneIP for patents involving ING5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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