Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ING4 Gene

protein-coding   GIFtS: 51
GCID: GC12M006759

inhibitor of growth family, member 4
 Explore 19 diseases affiliated with
ING4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ING4    

Aliases
for ING4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inhibitor Of Growth Family, Member 41 2
P29ING41
My0361
Brain My036 Protein2
Candidate Tumor Suppressor P33 ING1 Homolog2
Inhibitor Of Growth Protein 42

External Ids:    HGNC: 194231   Entrez Gene: 511472   Ensembl: ENSG000001116537   OMIM: 6085245   UniProtKB: Q9UNL43   

Export aliases for ING4 gene to outside databases

Previous GC identifers: GC12P006629 GC12P006754 GC12M006639 GC12M006630 GC12M006629


Summaries
for ING4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ING4:
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved
in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase
complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced
transcript variants have been observed that encode distinct proteins. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ING4_HUMAN, Q9UNL4
Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity
toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it
may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling
pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression
of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition
elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with
HIF prolyl hydroxylase 2 (EGLN1)

Gene Wiki entry for ING4


Genomic Views
for ING4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ING4 gene promoter:
         Pbx1a   Sp1   MAZR   MyoD   STAT5A   POU3F2   Gfi-1   ARP-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ING4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ING4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ING4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.32

ING4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ING4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006759:  view genomic region     (about GC identifiers)

Start:
 6,759,446 bp from pter      End:
 6,772,314 bp from pter
Size:
 12,869 bases      Orientation:
 minus strand

Proteins
for ING4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ING4_HUMAN, Q9UNL4 (See protein sequence)
Recommended Name: Inhibitor of growth protein 4  
Size: 249 amino acids; 28530 Da
Subunit: Homodimer. Interacts with H3K4me3 and to a lesser extent with H3K4me2, the interaction augments HBO1
acetylation activity on H3 tails. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6,
and one of PHF15, PHF16 and PHF17. Interacts with EP300, RELA and TP53; these interactions may be indirect. Interacts
with EGLN1
Subcellular location: Nucleus
Sequence caution: Sequence=AAG43153.1; Type=Frameshift; Positions=240, 243;
5 PDB 3D structures from and Proteopedia for ING4:
2K1J (3D)        2M1R (3D)        2PNX (3D)        2VNF (3D)        4AFL (3D)    
Secondary accessions: A4KYM4 A4KYM6 D3DUR8 Q0EF62 Q0EF63 Q4VBQ6 Q96E15 Q9H3J0
Alternative splicing: 8 isoforms:  Q9UNL4-1   Q9UNL4-2   Q9UNL4-3   Q9UNL4-4   Q9UNL4-5   Q9UNL4-6   Q9UNL4-7   Q9UNL4-8   
(Lacks the nuclear localization signal (NLS), resulting in increased cytoplasmic localization)

Explore the universe of human proteins at neXtProt for ING4: NX_Q9UNL4

Post-translational modifications:

  • Citrullination by PADI4 within the nuclear localization signal disrupts the interaction with p53 and increases
    • susceptibility to degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UNL4

    • ING4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001121054.1  NP_001121055.1  NP_001121056.1  NP_001121057.1  NP_001121058.1  NP_057246.2  

    ENSEMBL proteins: 
     ENSP00000343396   ENSP00000380024   ENSP00000415903   ENSP00000435867   ENSP00000433081  
     ENSP00000431892   ENSP00000397343   ENSP00000414008   ENSP00000412705   ENSP00000436406  
     ENSP00000437198  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ING4
    OriGene Protein Over-expression Lysate (see all 2): ING4
    OriGene Custom Protein Services for ING4 
    GenScript Custom Purified and Recombinant Proteins Services for ING4
    Novus Biologicals ING4 Proteins
    Novus Biologicals ING4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ING4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex IDA16387653
    GO:0005634nucleus IDA15029197


    ING4 for ontologies           About GeneDecksing



    ING4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: ING4
    OriGene Custom Antibody Services for ING4 
    GenScript Custom Superior Antibodies Services for ING4
    Novus Biologicals ING4 Antibodies
    Abcam antibodies for ING4 
    Uscn Antibodies for ING4
    Search ThermoFisher Antibodies for ING4

    Assay Products for ING4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ING4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ING4

    Protein Domains /
    Families
    for ING4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ING4 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR024610 ING_N
     IPR019786 Zinc_finger_PHD-type_CS
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q9UNL4

    ProtoNet protein and cluster: Q9UNL4

    1 Blocks protein family: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: ING4_HUMAN, Q9UNL4
    Domain: The PHD-type zinc finger mediates the binding to H3K4me3
    Domain: The N-terminal coiled-coil domain mediates homodimerization
    Similarity: Belongs to the ING family
    Similarity: Contains 1 PHD-type zinc finger


    Function
    for ING4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ING4_HUMAN, Q9UNL4
    Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity
    toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it
    may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling
    pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression
    of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition
    elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with
    HIF prolyl hydroxylase 2 (EGLN1)

    miRNA
    Products:            		miRTarBase miRNAs that target ING4:
    hsa-mir-650 (MIRT000448)

    OriGene 3'-UTR Clone (see all 6): ING4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ING4
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ING4 (see all 10):
    hsa-miR-3065-3p hsa-miR-3120-3p hsa-miR-650 hsa-miR-548g hsa-miR-214 hsa-miR-2116* hsa-miR-3154 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ING4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ING4 (see all 7)
    OriGene shRNA RFP: ING4
    OriGene siRNA: ING4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ING4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ING4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ING4 (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ING4 (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): ING4 (NM_001127582)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ING4
    Search LifeMap BioReagents cell lines for ING4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING4

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA16387653
    GO:0005515protein binding IPI15029197
    GO:0008270zinc ion binding IEA--
    GO:0035064methylated histone residue binding IDA16728974


    ING4 for ontologies           About GeneDecksing


    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ing4):
     homeostasis/metabolism  immune system  mortality/aging 

    ING4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ING4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ING4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for ING4 (Q9UNL42, 3 ENSP000003800244) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3CP684312, 3MINT-3982463 MINT-3982492 MINT-3982477 I2D: score=2 
    HIST1H3DP684312, 3MINT-3982463 MINT-3982492 MINT-3982477 I2D: score=2 
    HIST1H3EP684312, 3MINT-3982463 MINT-3982492 MINT-3982477 I2D: score=2 
    HIST1H3FP684312, 3MINT-3982463 MINT-3982492 MINT-3982477 I2D: score=2 
    HIST1H3GP684312, 3MINT-3982463 MINT-3982492 MINT-3982477 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IDA16387653
    GO:0006473protein acetylation IDA12750254
    GO:0006915apoptotic process IDA15251430
    GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA16387653
    GO:0007050cell cycle arrest IDA15251430


    ING4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ING4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ING4
    Search CenterWatch for drugs/clinical trials and news about ING4 

    Transcripts
    for ING4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ING4 gene (7 alternative transcripts): 
    NM_001127582.1  NM_001127583.1  NM_001127584.1  NM_001127585.1  NM_001127586.1  NM_016162.3  NM_198287.1  

    Unigene Cluster for ING4:

    Inhibitor of growth family, member 4
    Hs.524210  [show with all ESTs]
    Unigene Representative Sequence: BC095434
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341550(uc001qpv.4 uc001qpw.4 uc001qpy.4 uc001qpx.4 uc009zes.3 uc009zet.3 uc009zeu.3 uc009zev.3)
    ENST00000396807 ENST00000446105 ENST00000486287 ENST00000484795 ENST00000482489
    ENST00000469749 ENST00000472002 ENST00000488381 ENST00000444704 ENST00000423703
    ENST00000412586 ENST00000437149 ENST00000467678 ENST00000479301 ENST00000493873
    ENST00000493267

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 6): ING4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ING4
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ING4 (see all 10):
    hsa-miR-3065-3p hsa-miR-3120-3p hsa-miR-650 hsa-miR-548g hsa-miR-214 hsa-miR-2116* hsa-miR-3154 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ING4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ING4 (see all 7)
    OriGene shRNA RFP: ING4
    OriGene siRNA: ING4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ING4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ING4 (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ING4 (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): ING4 (NM_001127582)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ING4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ING4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ING4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ING4

    Additional cDNA sequence: 

    AB197695.1 AB197696.1 AB197697.1 AF063594.1 AF110645.1 AF156552.1 AK293169.1 AK303354.1 
    AK313621.1 BC007781.2 BC013038.2 BC095434.1 EF152349.1 EF152350.1 EF152351.1 EF152352.1 

    14 DOTS entries:

    DT.444794  DT.100813613  DT.417440  DT.92429632  DT.100669859  DT.40121290  DT.121171421  DT.95073601 
    DT.100799981  DT.100813607  DT.121171423  DT.95105352  DT.95105354  DT.92064217 

    24/225 AceView cDNA sequences (see all 225):

    BM970448 BQ017358 W24291 BU181515 AA643092 CA488048 CB119734 NM_198287 
    CB850518 BF434392 BU627656 AL526123 AI364043 AA356566 AL534106 AA130135 
    BX421859 BM724484 AF156552 BQ575730 BM994099 CB157524 CB119530 BF513966 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for ING4 (see all 22)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ·
    SP1:        -           -     -                                   -           -                                                                                 
    SP2:        -           -     -                                   -           -                                                                                 
    SP3:        -           -     -                             -     -           -                                                                                 
    SP4:        -     -     -     -                                   -           -                                                                                 
    SP5:                    -     -                             -     -           -                                                                                 

    ExUns: 11h
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ING4

    Expression
    for ING4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ING4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ING4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ING4

    SOURCE GeneReport for Unigene cluster: Hs.524210
        SABiosciences Expression via Pathway-Focused PCR Arrays including ING4: 
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ING4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ING4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ING4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ING4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING4

    Orthologs
    for ING4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ING4 gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ING41 inhibitor of growth family, member 4 81.66(n)
    96.79(a)    		   418281  NM_001006251.1  NP_001006251.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ING46
    		 --
    		 97(a)
    		 1 ↔ 1
    		 GL343381.1(852327-859475)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb11d092 Transcribed sequence with moderate similarity to protein more 79(n)    57043060 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG92933   -- 42(a)   34B9   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y43H11AL.16
    lsy-136
    (see all 3)    		 --
    		 6(a)
    12(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 II(222700-232741)
    IV(16862363-16865452)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ING16
    ING26
    		 PHD finger protein-like protein
    		 28(a)
    13(a)
    		 possible ortholog
    1 ↔ many
    		 3(8675956-8678220)
    1(20304567-20307024)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 PHD-finger domain containing protein, putative, ex...
    PHD-finger domain containing protein, putative, ex...
    		 31(a)
    20(a)
    		 possible ortholog
    1 ↔ many
    		 3(2408857-2412428)
    3(30784503-30789908)


    ENSEMBL Gene Tree for ING4 (if available)
    TreeFam Gene Tree for ING4 (if available) 

    Paralogs
    for ING4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ING4 gene
    ING22  ING52  ING32  ING12  
    5 SIMAP similar genes for ING4 using alignment to 6 protein entries:     ING4_HUMAN (see all proteins):
    ING5    ING3    ING2    ING2b    ING1

    ING4 for paralogs           About GeneDecksing



    Genomic Variants
    for ING4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/252 NCBI SNPs in ING4 are shown (see all 252)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1872115361,2
    		--6759254(+) CTCTAA/CTAAAA 6 -- ds50010--------
    rs1475341831,2
    		--6759347(+) GGAGGC/TGGAGA 6 -- ds50010--------
    rs1402422011,2
    		--6759348(+) GAGGCA/GGAGAC 6 -- ds50010--------
    rs1920964611,2
    		--6759454(+) AGTATA/GGCAGT 6 -- ds50010--------
    rs1809527131,2
    		--6759506(+) TGAAAC/GATGTT 6 -- ds50010--------
    rs79619401,2
    		C,F,H,--6759568(+) AGGCCC/TACCCT 6 -- ds500124Minor allele frequency- T:0.06NS EA NA WA CSA 1873
    rs110643011,2
    		C--6759645(+) CATGTC/TGTGTC 6 -- ds5001 ese30--------
    rs740570511,2
    		C,--6759646(+) ATGTCG/ATGTCC 6 -- ds50012Minor allele frequency- A:0.15WA 120
    rs79620471,2
    		C,H,--6759679(+) CACATC/TGCATC 6 -- ds5001 ese314Minor allele frequency- T:0.01NA WA CSA EA 377
    rs1455322741,2
    		--6759934(+) GGAAGA/GGAATG 6 -- ut310--------

    HapMap Linkage Disequilibrium report for ING4 (6759446 - 6772314 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ING4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ING4
    DNA2.0 Custom Variant and Variant Library Synthesis for ING4

    Disorders / Diseases
    for ING4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ING4 for disorders           About GeneDecksing

    OMIM gene information: 608524    OMIM disorders: --

    19 diseases for ING4:    About MalaCards
    cryptogenic organizing pneumonia    squamous cell carcinoma    pulmonary fibrosis    gastric adenocarcinoma
    lung adenocarcinoma    fibrosis    adenocarcinoma    gastric cancer
    lung carcinoma    breast carcinoma    colorectal cancer    astrocytoma
    lung cancer    carcinoma    myeloma    glioblastoma
    pneumonia    hypoxia    melanoma

    1 Novoseek disease relationship for ING4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 23.1 16 15935570 (4), 16096374 (3), 18789575 (3), 19571607 (2) (see all 7)


    Export disorders for ING4 gene to outside databases

    Publications
    for ING4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ING4 gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with ING4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. (PubMed id 12750254)1, 2, 3, 9 Shiseki M....Harris C.C. (2003)
    2. Nuclear localization signal of ING4 plays a key role in its binding to p53. (PubMed id 15882981)1, 2, 9 Zhang X....Han Z.G. (2005)
    3. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. (PubMed id 15029197)1, 2, 9 Garkavtsev I.... Jain R.K. (2004)
    4. Crystal structure of inhibitor of growth 4 (ING4) dime rization domain reveals functional organization of ING family of chromatin-bindi ng proteins. (PubMed id 22334692)1, 2 Culurgioni S....Blanco F.J. (2012)
    5. Citrullination of inhibitor of growth 4 (ING4) by pep tidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53. (PubMed id 21454715)1, 2 Guo Q. and Fast W. (2011)
    6. Molecular basis of histone H3K4me3 recognition by ING 4. (PubMed id 18381289)1, 2 Palacios A....Blanco F.J. (2008)
    7. Detection of novel mRNA splice variants of human ING4 tumor suppressor gene. (PubMed id 17325660)1, 2 Raho G.... Greco A. (2007)
    8. Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility. (PubMed id 16973615)1, 2 Unoki M.... Harris C.C. (2006)
    9. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. (PubMed id 16728974)1, 2 Shi X....Gozani O. (2006)
    10. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2 Doyon Y.... Cote J. (2006)

    External Searches for ING4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ING4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51147 HGNC: 19423 AceView: ING4 Ensembl:ENSG00000111653 euGenes: HUgn51147
    ECgene: ING4 H-InvDB: ING4

    Other Databases showing ING4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ING4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ING4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ING4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ING4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ING4 gene:
    Search GeneIP for patents involving ING4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ING4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for ING4   OriGene shRNA RFP for ING4  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ING4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ING4  
     OriGene Protein Over-expression Lysate for ING4   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ING4   OriGene 3'-UTR Clone for ING4  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ING4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ING4  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ING4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ING4   OriGene Custom Protein Services for ING4  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ING4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ING4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ING4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ING4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ING4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ING4
     GenScript Custom Purified and Recombinant Proteins Services for ING4 GenScript cDNA clones with any tag delivered in your preferred vector for ING4
     GenScript Custom Assay Services for ING4 GenScript Custom Superior Antibodies Services for ING4
     GenScript Custom overexpressing Cell Line Services for ING4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ING4 promoter
     Search Chromatin IP Primers for ING4
     RT2 qPCR Primer Assay in human, mouse, rat ING4
     GNC Network for ING4
     SABiosciences PCR Arrays including human, mouse, rat ING4
     Search Tocris compounds for ING4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ING4 antibodies
     ING4 proteins
     ING4 lysates
     Antibodies for ING4
     See all of Abcam's Antibodies, Kits and Proteins for ING4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ING4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ING4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING4
     SwitchGear 3'UTR luciferase reporter plasmids for ING4
     SwitchGear Promoter luciferase reporter plasmids for ING4
     Search ThermoFisher Antibodies for ING4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING4
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ING4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4