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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ING4 Gene

protein-coding   GIFtS: 52
GCID: GC12M006759

Inhibitor Of Growth Family, Member 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Inhibitor Of Growth Family, Member 41 2
p29ING42 3
Brain My036 Protein2
Candidate Tumor Suppressor P33 ING1 Homolog2
Inhibitor Of Growth Protein 42
my0362

External Ids:    HGNC: 194231   Entrez Gene: 511472   Ensembl: ENSG000001116537   OMIM: 6085245   UniProtKB: Q9UNL43   

Export aliases for ING4 gene to outside databases

Previous GC identifers: GC12P006629 GC12P006754 GC12M006639 GC12M006630 GC12M006629


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ING4 Gene:
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins
involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl
transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively
spliced transcript variants have been observed that encode distinct proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for ING4 Gene: 
ING4 (inhibitor of growth family, member 4) is a protein-coding gene. Diseases associated with ING4 include cryptogenic organizing pneumonia, and gastric adenocarcinoma. GO annotations related to this gene include transcription coactivator activity and methylated histone residue binding. An important paralog of this gene is ING2.

UniProtKB/Swiss-Prot: ING4_HUMAN, Q9UNL4
Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced
activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin
acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional
output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through
transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress
loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's
(HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1)

Gene Wiki entry for ING4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009759.16  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ING4 gene promoter:
         Pbx1a   Sp1   MAZR   MyoD   STAT5A   POU3F2   Gfi-1   ARP-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidING4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ING4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ING4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.32

ING4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ING4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006759:  view genomic region     (about GC identifiers)

Start:
6,759,446 bp from pter      End:
6,772,314 bp from pter
Size:
12,869 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ING4_HUMAN, Q9UNL4 (See protein sequence)
Recommended Name: Inhibitor of growth protein 4  
Size: 249 amino acids; 28530 Da
Subunit: Homodimer. Interacts with H3K4me3 and to a lesser extent with H3K4me2, the interaction augments HBO1
acetylation activity on H3 tails. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1,
MEAF6, and one of PHF15, PHF16 and PHF17. Interacts with EP300, RELA and TP53; these interactions may be
indirect. Interacts with EGLN1
Subcellular location: Nucleus
Sequence caution: Sequence=AAG43153.1; Type=Frameshift; Positions=240, 243;
5 PDB 3D structures from and Proteopedia for ING4:
2K1J (3D)        2M1R (3D)        2PNX (3D)        2VNF (3D)        4AFL (3D)    
Secondary accessions: A4KYM4 A4KYM6 D3DUR8 Q0EF62 Q0EF63 Q4VBQ6 Q96E15 Q9H3J0
Alternative splicing: 8 isoforms:  Q9UNL4-1   Q9UNL4-2   Q9UNL4-3   Q9UNL4-4   Q9UNL4-5   Q9UNL4-6   Q9UNL4-7   Q9UNL4-8   
(Lacks the nuclear localization signal (NLS), resulting in increased cytoplasmic localization)

Explore the universe of human proteins at neXtProt for ING4: NX_Q9UNL4

Explore proteomics data for ING4 at MOPED 

Post-translational modifications:

  • UniProtKB: Citrullination by PADI4 within the nuclear localization signal disrupts the interaction with p53 and increases
    susceptibility to degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UNL4

  • ING4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ING4 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001121054.1  NP_001121055.1  NP_001121056.1  NP_001121057.1  NP_001121058.1  NP_057246.2  

    ENSEMBL proteins: 
     ENSP00000343396   ENSP00000380024   ENSP00000415903   ENSP00000435867   ENSP00000433081  
     ENSP00000431892   ENSP00000414008   ENSP00000412705   ENSP00000397343   ENSP00000473635  
     ENSP00000436406   ENSP00000437198  

    Human Recombinant Protein Products for ING4: 
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    Novus Biologicals ING4 Proteins
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    Sino Biological Recombinant Protein for ING4
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ING4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex IDA16387653
    GO:0005634nucleus IDA15029197

    ING4 for ontologies           About GeneDecksing



    ING4 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for ING4 
    Cloud-Clone Corp. CLIAs for ING4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PHF: Zinc fingers, PHD-type

    5/6 InterPro protein domains (see all 6):
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR024610 ING_N
     IPR019786 Zinc_finger_PHD-type_CS
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q9UNL4

    ProtoNet protein and cluster: Q9UNL4

    1 Blocks protein domain: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: ING4_HUMAN, Q9UNL4
    Domain: The PHD-type zinc finger mediates the binding to H3K4me3
    Domain: The N-terminal coiled-coil domain mediates homodimerization
    Similarity: Belongs to the ING family
    Similarity: Contains 1 PHD-type zinc finger


    ING4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ING4_HUMAN, Q9UNL4
    Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced
    activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin
    acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional
    output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through
    transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress
    loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's
    (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA16387653
    GO:0005515protein binding IPI12750254
    GO:0008270zinc ion binding IEA--
    GO:0035064methylated histone residue binding IDA16728974
         
    ING4 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ing4):
     homeostasis/metabolism  immune system  mortality/aging 

    ING4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ING4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ING4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ING4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ING4 

    miRNA
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    miRTarBase miRNAs that target ING4:
    hsa-mir-650 (MIRT000448)

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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ING4 (see all 10):
    hsa-miR-3065-3p hsa-miR-3120-3p hsa-miR-650 hsa-miR-548g hsa-miR-214 hsa-miR-2116* hsa-miR-3154 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidING4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ING4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for ING4 (Q9UNL42, 3 ENSP000003800244) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3CP684312, 3MINT-3982463 MINT-3982492 MINT-3982477 I2D: score=2 
    HIST1H3DP684312, 3MINT-3982463 MINT-3982492 MINT-3982477 I2D: score=2 
    HIST1H3EP684312, 3MINT-3982463 MINT-3982492 MINT-3982477 I2D: score=2 
    HIST1H3FP684312, 3MINT-3982463 MINT-3982492 MINT-3982477 I2D: score=2 
    HIST1H3GP684312, 3MINT-3982463 MINT-3982492 MINT-3982477 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IDA16387653
    GO:0006473protein acetylation IDA12750254
    GO:0006915apoptotic process IDA15251430
    GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA16387653
    GO:0007050cell cycle arrest IDA15251430

    ING4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ING4

    Search CenterWatch for drugs/clinical trials and news about ING4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ING4 gene (7 alternative transcripts): 
    NM_001127582.1  NM_001127583.1  NM_001127584.1  NM_001127585.1  NM_001127586.1  NM_016162.3  NM_198287.1  

    Unigene Cluster for ING4:

    Inhibitor of growth family, member 4
    Hs.524210  [show with all ESTs]
    Unigene Representative Sequence: BC095434
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341550(uc001qpv.4 uc001qpw.4 uc001qpy.4 uc001qpx.4 uc009zes.3 uc009zet.3 uc009zeu.3 uc009zev.3)
    ENST00000396807 ENST00000446105 ENST00000486287 ENST00000484795 ENST00000482489
    ENST00000469749 ENST00000472002 ENST00000488381 ENST00000423703 ENST00000412586
    ENST00000444704 ENST00000437149 ENST00000467678 ENST00000479301 ENST00000493873
    ENST00000493267
    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ING4 (see all 10):
    hsa-miR-3065-3p hsa-miR-3120-3p hsa-miR-650 hsa-miR-548g hsa-miR-214 hsa-miR-2116* hsa-miR-3154 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidING4 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING4
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ING4

    Additional mRNA sequence: 

    AB197695.1 AB197696.1 AB197697.1 AF063594.1 AF110645.1 AF156552.1 AK293169.1 AK303354.1 
    AK313621.1 BC007781.2 BC013038.2 BC095434.1 EF152349.1 EF152350.1 EF152351.1 EF152352.1 

    14 DOTS entries:

    DT.444794  DT.100813613  DT.417440  DT.92429632  DT.100669859  DT.40121290  DT.121171421  DT.95073601 
    DT.100799981  DT.100813607  DT.121171423  DT.95105352  DT.95105354  DT.92064217 

    24/225 AceView cDNA sequences (see all 225):

    BM724484 AI687958 AA356566 AL526123 AW954171 CB157524 AA130135 BU627656 
    BQ575730 CD108916 BG742312 T80761 CB960584 CB850518 AA504961 AL534106 
    AI472417 AI081362 W24291 CB119731 NM_198287 BM970448 BF513966 BM723442 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for ING4 (see all 22)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ·
    SP1:        -           -     -                                   -           -                                                                                 
    SP2:        -           -     -                                   -           -                                                                                 
    SP3:        -           -     -                             -     -           -                                                                                 
    SP4:        -     -     -     -                                   -           -                                                                                 
    SP5:                    -     -                             -     -           -                                                                                 

    ExUns: 11h
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ING4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ING4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ING4 Expression
    About this image


    See ING4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ING4

    SOURCE GeneReport for Unigene cluster: Hs.524210
        SABiosciences Expression via Pathway-Focused PCR Arrays including ING4: 
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ING4 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ing41 , 5 inhibitor of growth family, member 41, 5 95.16(n)1
    98.79(a)1
      6 (59.17 cM)5
    280191  NM_133345.21  NP_579923.11 
     1250397605 
    chicken
    (Gallus gallus)
    Aves ING41 inhibitor of growth family, member 4 81.66(n)
    96.79(a)
      418281  NM_001006251.1  NP_001006251.1 
    lizard
    (Anolis carolinensis)
    Reptilia ING46
    Uncharacterized protein
    97(a)
    1 ↔ 1
    GL343381.1(851941-859943)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb11d092 Transcribed sequence with moderate similarity to protein more 79(n)    57043060 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92933   -- 42(a)   34B9   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO236
    Probable component of the Rpd3 histone deacetylase...
    18(a)
    1 → many
    XIV(441366-442358)
    barley
    (Hordeum vulgare)
    Liliopsida AJ472374.12   -- 73.77(n)    AJ472374.1 


    ENSEMBL Gene Tree for ING4 (if available)
    TreeFam Gene Tree for ING4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ING4 gene
    ING22  ING52  ING32  ING12  
    5 SIMAP similar genes for ING4 using alignment to 7 protein entries:     ING4_HUMAN (see all proteins):
    ING5    ING3    ING2    ING2b    ING1

    ING4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/322 SNPs in ING4 are shown (see all 322)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872115361,2
    C--6759254(+) CTCTAA/CTAAAA 6 -- ds50010--------
    rs1475341831,2
    C--6759347(+) GGAGGC/TGGAGA 6 -- ds50010--------
    rs1402422011,2
    --6759348(+) GAGGCA/GGAGAC 6 -- ds50010--------
    rs1920964611,2
    --6759454(+) AGTATA/GGCAGT 6 -- ds50010--------
    rs1809527131,2
    --6759506(+) TGAAAC/GATGTT 6 -- ds50010--------
    rs79619401,2
    C,F,H--6759568(+) AGGCCC/TACCCT 6 -- ds500124Minor allele frequency- T:0.06NS EA NA WA CSA 1873
    rs110643011,2
    C--6759645(+) CATGTC/TGTGTC 6 -- ds5001 ese30--------
    rs740570511,2
    C,F--6759646(+) ATGTCG/ATGTCC 6 -- ds50012Minor allele frequency- A:0.15WA 120
    rs79620471,2
    C,H--6759679(+) CACATC/TGCATC 6 -- ds5001 ese314Minor allele frequency- T:0.01NA WA CSA EA 377
    rs1455322741,2
    C--6759934(+) GGAAGA/GGAATG 6 -- ut310--------

    HapMap Linkage Disequilibrium report for ING4 (6759446 - 6772314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ING4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509452CNV Insertion20534489
    nsv898635CNV Loss21882294
    nsv832323CNV Loss17160897
    nsv832322CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608524    OMIM disorders: --

    17 diseases for ING4:    About MalaCards
    cryptogenic organizing pneumonia    gastric adenocarcinoma    lung adenocarcinoma    pneumonia
    hypoxia    pulmonary fibrosis    astrocytoma    adenocarcinoma
    glioblastoma    gastric cancer    myeloma    colorectal cancer
    lung cancer    melanoma    squamous cell carcinoma    colon cancer
    breast cancer


    ING4 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ING4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 23.1 16 15935570 (4), 16096374 (3), 18789575 (3), 19571607 (2) (see all 7)


    Export disorders for ING4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ING4 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with ING4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. (PubMed id 12750254)1, 2, 3, 9 Shiseki M....Harris C.C. (2003)
    2. Nuclear localization signal of ING4 plays a key role in its binding to p53. (PubMed id 15882981)1, 2, 9 Zhang X....Han Z.G. (2005)
    3. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. (PubMed id 15029197)1, 2, 9 Garkavtsev I.... Jain R.K. (2004)
    4. Crystal structure of inhibitor of growth 4 (ING4) dime rization domain reveals functional organization of ING family of chromatin-bindi ng proteins. (PubMed id 22334692)1, 2 Culurgioni S....Blanco F.J. (2012)
    5. Citrullination of inhibitor of growth 4 (ING4) by pep tidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53. (PubMed id 21454715)1, 2 Guo Q. and Fast W. (2011)
    6. Molecular basis of histone H3K4me3 recognition by ING 4. (PubMed id 18381289)1, 2 Palacios A....Blanco F.J. (2008)
    7. Detection of novel mRNA splice variants of human ING4 tumor suppressor gene. (PubMed id 17325660)1, 2 Raho G.... Greco A. (2007)
    8. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. (PubMed id 16728974)1, 2 Shi X....Gozani O. (2006)
    9. Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility. (PubMed id 16973615)1, 2 Unoki M.... Harris C.C. (2006)
    10. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2 Doyon Y.... Cote J. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51147 HGNC: 19423 AceView: ING4 Ensembl:ENSG00000111653 euGenes: HUgn51147
    ECgene: ING4 H-InvDB: ING4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ING4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ING4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ING4 gene:
    Search GeneIP for patents involving ING4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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