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Aliases for ING4 Gene

Aliases for ING4 Gene

  • Inhibitor Of Growth Family, Member 4 2 3
  • P29ING4 3 4
  • Candidate Tumor Suppressor P33 ING1 Homolog 3
  • Inhibitor Of Growth Protein 4 3
  • Brain My036 Protein 3
  • My036 3

External Ids for ING4 Gene

Summaries for ING4 Gene

Entrez Gene Summary for ING4 Gene

  • This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for ING4 Gene

ING4 (Inhibitor Of Growth Family, Member 4) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include transcription coactivator activity and methylated histone binding. An important paralog of this gene is ING2.

UniProtKB/Swiss-Prot for ING4 Gene

  • Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factors (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).

Gene Wiki entry for ING4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ING4 Gene

Genomics for ING4 Gene

Genomic Location for ING4 Gene

Start:
6,650,280 bp from pter
End:
6,663,148 bp from pter
Size:
12,869 bases
Orientation:
Minus strand

Genomic View for ING4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ING4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ING4 Gene

Regulatory Elements for ING4 Gene

Proteins for ING4 Gene

  • Protein details for ING4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNL4-ING4_HUMAN
    Recommended name:
    Inhibitor of growth protein 4
    Protein Accession:
    Q9UNL4
    Secondary Accessions:
    • A4KYM4
    • A4KYM6
    • D3DUR8
    • Q0EF62
    • Q0EF63
    • Q4VBQ6
    • Q96E15
    • Q9H3J0

    Protein attributes for ING4 Gene

    Size:
    249 amino acids
    Molecular mass:
    28530 Da
    Quaternary structure:
    • Homodimer. Interacts with H3K4me3 and to a lesser extent with H3K4me2, the interaction augments HBO1 acetylation activity on H3 tails. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with EP300, RELA and TP53; these interactions may be indirect. Interacts with EGLN1.
    SequenceCaution:
    • Sequence=AAG43153.1; Type=Frameshift; Positions=240, 243; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ING4 Gene

    Alternative splice isoforms for ING4 Gene

neXtProt entry for ING4 Gene

Proteomics data for ING4 Gene at MOPED

Post-translational modifications for ING4 Gene

  • Citrullination by PADI4 within the nuclear localization signal disrupts the interaction with p53 and increases susceptibility to degradation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys66

No data available for DME Specific Peptides for ING4 Gene

Domains for ING4 Gene

Gene Families for ING4 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

UniProtKB/Swiss-Prot:

ING4_HUMAN
Domain:
  • The PHD-type zinc finger mediates the binding to H3K4me3:
    • Q9UNL4
  • The N-terminal coiled-coil domain mediates homodimerization:
    • Q9UNL4
Family:
  • Belongs to the ING family.:
    • Q9UNL4
Similarity:
  • Contains 1 PHD-type zinc finger.:
    • Q9UNL4
genes like me logo Genes that share domains with ING4: view

Function for ING4 Gene

Molecular function for ING4 Gene

UniProtKB/Swiss-Prot Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factors (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).

Gene Ontology (GO) - Molecular Function for ING4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 16387653
GO:0005515 protein binding IPI 12750254
GO:0008270 zinc ion binding IEA --
GO:0035064 methylated histone binding IDA 16728974
genes like me logo Genes that share ontologies with ING4: view

Phenotypes for ING4 Gene

genes like me logo Genes that share phenotypes with ING4: view

miRNA for ING4 Gene

miRTarBase miRNAs that target ING4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ING4 Gene

Localization for ING4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ING4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ING4 Gene COMPARTMENTS Subcellular localization image for ING4 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ING4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 16387653
GO:0005634 nucleus IDA 15029197
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ING4: view

Pathways for ING4 Gene

genes like me logo Genes that share pathways with ING4: view

Pathways by source for ING4 Gene

Gene Ontology (GO) - Biological Process for ING4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IDA 16387653
GO:0006325 chromatin organization TAS --
GO:0006473 protein acetylation IDA 12750254
GO:0006915 apoptotic process IDA 15251430
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA 16387653
genes like me logo Genes that share ontologies with ING4: view

Transcripts for ING4 Gene

Unigene Clusters for ING4 Gene

Inhibitor of growth family, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ING4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: - - -
SP9: - - - - -
SP10: - - - - - - -
SP11: - - -
SP12: - - - -
SP13: - -
SP14: - - - -
SP15: - -
SP16: - - -
SP17: - - - - -
SP18: - - -
SP19: - - - - - - - -
SP20:
SP21: - - -
SP22: -

ExUns: 11h
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for ING4 Gene

GeneLoc Exon Structure for
ING4
ECgene alternative splicing isoforms for
ING4

Expression for ING4 Gene

mRNA expression in normal human tissues for ING4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ING4 Gene

SOURCE GeneReport for Unigene cluster for ING4 Gene Hs.524210

genes like me logo Genes that share expressions with ING4: view

Orthologs for ING4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ING4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ING4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ING4 36
  • 94.58 (n)
  • 97.15 (a)
ING4 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 91 (a)
OneToMany
-- 37
  • 99 (a)
OneToMany
ING4 36
  • 95.93 (n)
  • 99.19 (a)
mouse
(Mus musculus)
Mammalia Ing4 36
  • 92.95 (n)
  • 96.75 (a)
Ing4 16
Ing4 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ING4 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ing4 36
  • 96.05 (n)
  • 99.18 (a)
chicken
(Gallus gallus)
Aves ING4 36
  • 79.81 (n)
  • 93.9 (a)
ING4 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ING4 37
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ing4 36
  • 76.19 (n)
  • 86.53 (a)
zebrafish
(Danio rerio)
Actinopterygii ing4 36
  • 73.2 (n)
  • 82.45 (a)
ing4 37
  • 81 (a)
OneToOne
wufb11d09 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009992 36
  • 58.4 (n)
  • 58.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9293 36
  • 58.67 (n)
  • 56.1 (a)
CG9293 37
  • 49 (a)
OneToMany
CG9293 38
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO23 37
  • 19 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.14443 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
OneToMany
Species with no ortholog for ING4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for ING4 Gene

ENSEMBL:
Gene Tree for ING4 (if available)
TreeFam:
Gene Tree for ING4 (if available)

Paralogs for ING4 Gene

Paralogs for ING4 Gene

Selected SIMAP similar genes for ING4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ING4: view

Variants for ING4 Gene

Sequence variations from dbSNP and Humsavar for ING4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs14542 -- 6,650,772(+) GGGAA(C/T)GGAGA utr-variant-3-prime, nc-transcript-variant
rs2365101 -- 6,651,645(+) caagc(C/T)attct intron-variant
rs2365102 -- 6,651,784(+) tgatc(C/T)gctca intron-variant
rs3809244 -- 6,663,709(+) GATCA(A/C)CTTTC upstream-variant-2KB
rs3809245 -- 6,664,435(+) AGTAT(C/T)TTAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ING4 Gene

Variant ID Type Subtype PubMed ID
nsv509452 CNV Insertion 20534489
nsv832322 CNV Loss 17160897
nsv898635 CNV Loss 21882294
nsv832323 CNV Loss 17160897

Relevant External Links for ING4 Gene

HapMap Linkage Disequilibrium report
ING4

Disorders for ING4 Gene

(1) Novoseek inferred disease relationships for ING4 Gene

Disease -log(P) Hits PubMed IDs
tumors 23.1 15
genes like me logo Genes that share disorders with ING4: view

No data available for UniProtKB/Swiss-Prot for ING4 Gene

Publications for ING4 Gene

  1. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. (PMID: 12750254) Shiseki M. … Harris C.C. (Cancer Res. 2003) 2 3 4 23
  2. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. (PMID: 15029197) Garkavtsev I. … Jain R.K. (Nature 2004) 3 4 23
  3. Nuclear localization signal of ING4 plays a key role in its binding to p53. (PMID: 15882981) Zhang X. … Han Z.G. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  4. Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas. (PMID: 15935570) Gunduz M. … Nagai N. (Gene 2005) 3 23
  5. Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4. (PMID: 16096374) Ozer A. … Bruick R.K. (Cell Cycle 2005) 3 23

Products for ING4 Gene

Sources for ING4 Gene

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