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ING4 Gene

protein-coding   GIFtS: 55
GCID: GC12M006759

Inhibitor Of Growth Family, Member 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inhibitor Of Growth Family, Member 41 2
p29ING42 3
Brain My036 Protein2
Candidate Tumor Suppressor P33 ING1 Homolog2
Inhibitor Of Growth Protein 42
my0362

External Ids:    HGNC: 194231   Entrez Gene: 511472   Ensembl: ENSG000001116537   OMIM: 6085245   UniProtKB: Q9UNL43   

Export aliases for ING4 gene to outside databases

Previous GC identifers: GC12P006629 GC12P006754 GC12M006639 GC12M006630 GC12M006629


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ING4 Gene:
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins
involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl
transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively
spliced transcript variants have been observed that encode distinct proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for ING4 Gene:
ING4 (inhibitor of growth family, member 4) is a protein-coding gene. Diseases associated with ING4 include cryptogenic organizing pneumonia, and lung adenocarcinoma. GO annotations related to this gene include transcription coactivator activity and methylated histone residue binding. An important paralog of this gene is ING2.

UniProtKB/Swiss-Prot: ING4_HUMAN, Q9UNL4
Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced
activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin
acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional
output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through
transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress
loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's
(HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1)

Gene Wiki entry for ING4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ING4 gene promoter:
         Pbx1a   Sp1   MAZR   MyoD   STAT5A   POU3F2   Gfi-1   ARP-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidING4 promoter sequence
   Search Chromatin IP Primers for ING4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ING4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.32

ING4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ING4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006759:  view genomic region     (about GC identifiers)

Start:
6,759,446 bp from pter      End:
6,772,314 bp from pter
Size:
12,869 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ING4_HUMAN, Q9UNL4 (See protein sequence)
Recommended Name: Inhibitor of growth protein 4  
Size: 249 amino acids; 28530 Da
Subunit: Homodimer. Interacts with H3K4me3 and to a lesser extent with H3K4me2, the interaction augments HBO1
acetylation activity on H3 tails. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1,
MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with EP300, RELA and TP53; these interactions may be
indirect. Interacts with EGLN1
Sequence caution: Sequence=AAG43153.1; Type=Frameshift; Positions=240, 243;
5 PDB 3D structures from and Proteopedia for ING4:
2K1J (3D)        2M1R (3D)        2PNX (3D)        2VNF (3D)        4AFL (3D)    
Secondary accessions: A4KYM4 A4KYM6 D3DUR8 Q0EF62 Q0EF63 Q4VBQ6 Q96E15 Q9H3J0
Alternative splicing: 8 isoforms:  Q9UNL4-1   Q9UNL4-2   Q9UNL4-3   Q9UNL4-4   Q9UNL4-5   Q9UNL4-6   Q9UNL4-7   Q9UNL4-8   
(Lacks the nuclear localization signal (NLS), resulting in increased cytoplasmic localization)

Explore the universe of human proteins at neXtProt for ING4: NX_Q9UNL4

Explore proteomics data for ING4 at MOPED

Post-translational modifications: 

  • Citrullination by PADI4 within the nuclear localization signal disrupts the interaction with p53 and increases
    susceptibility to degradation1
  • Ubiquitination2 at Lys66
  • Modification sites at PhosphoSitePlus

  • See ING4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001121054.1  NP_001121055.1  NP_001121056.1  NP_001121057.1  NP_001121058.1  NP_057246.2  

    ENSEMBL proteins: 
     ENSP00000343396   ENSP00000380024   ENSP00000415903   ENSP00000435867   ENSP00000433081  
     ENSP00000431892   ENSP00000414008   ENSP00000412705   ENSP00000397343   ENSP00000473635  
     ENSP00000436406   ENSP00000437198  
    Reactome Protein details: Q9UNL4

    ING4 Human Recombinant Protein Products:

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    Novus Biologicals ING4 Proteins
    Novus Biologicals ING4 Lysates
    Sino Biological Recombinant Protein for ING4
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ING4

    ING4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ING4
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    Novus Biologicals ING4 Antibodies
    Abcam antibodies for ING4
    Cloud-Clone Corp. Antibodies for ING4
    Search ThermoFisher Antibodies for ING4
    LSBio Antibodies in human, mouse, rat for ING4

    ING4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ING4
    Cloud-Clone Corp. CLIAs for ING4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 8):
     IPR001965 Znf_PHD
     IPR028647 ING4
     IPR013083 Znf_RING/FYVE/PHD
     IPR028651 ING_fam
     IPR024610 ING_N

    Graphical View of Domain Structure for InterPro Entry Q9UNL4

    ProtoNet protein and cluster: Q9UNL4

    1 Blocks protein domain: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: ING4_HUMAN, Q9UNL4
    Domain: The PHD-type zinc finger mediates the binding to H3K4me3
    Domain: The N-terminal coiled-coil domain mediates homodimerization
    Similarity: Belongs to the ING family
    Similarity: Contains 1 PHD-type zinc finger


    ING4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ING4_HUMAN, Q9UNL4
    Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced
    activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin
    acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional
    output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through
    transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress
    loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's
    (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA16387653
    GO:0005515protein binding IPI12750254
    GO:0008270zinc ion binding IEA--
    GO:0035064methylated histone residue binding IDA16728974
         
    ING4 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ing4):
     homeostasis/metabolism  immune system  mortality/aging 

    ING4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ING4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ING4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ING4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ING4

    miRNA
    Products:
        
    miRTarBase miRNAs that target ING4:
    hsa-mir-650 (MIRT000448), hsa-mir-335-5p (MIRT017117)

    Block miRNA regulation of human, mouse, rat ING4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ING4 (see all 10):
    hsa-miR-3065-3p hsa-miR-3120-3p hsa-miR-650 hsa-miR-548g hsa-miR-214 hsa-miR-2116* hsa-miR-3154 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidING4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ING4
    Predesigned siRNA for gene silencing in human, mouse, rat ING4

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ING4

    Clone
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    OriGene clones in human, mouse for ING4 (see all 32)
    OriGene ORF clones in mouse, rat for ING4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): ING4 (NM_001127582)
    Sino Biological Human cDNA Clone for ING4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ING4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ING4_HUMAN, Q9UNL4: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex IDA16387653
    GO:0005634nucleus IDA15029197
    GO:0005654nucleoplasm TAS--

    ING4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ING4 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for ING4
        HATs acetylate histones



    ING4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ING4: 
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ING4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ING4 (Q9UNL41, 2, 3 ENSP000003800244) via UniProtKB, MINT, STRING, and/or I2D (see all 133)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3CP684311, 2, 3EBI-2866661,EBI-79722 MINT-3982463 MINT-3982492 MINT-3982477 I2D: score=2 
    HIST1H3DP684311, 2, 3EBI-2866661,EBI-79722 MINT-3982463 MINT-3982492 MINT-3982477 I2D: score=2 
    HIST1H3EP684311, 2, 3EBI-2866661,EBI-79722 MINT-3982463 MINT-3982492 MINT-3982477 I2D: score=2 
    HIST1H3FP684311, 2, 3EBI-2866661,EBI-79722 MINT-3982463 MINT-3982492 MINT-3982477 I2D: score=2 
    HIST1H3GP684311, 2, 3EBI-2866661,EBI-79722 MINT-3982463 MINT-3982492 MINT-3982477 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IDA16387653
    GO:0006325chromatin organization TAS--
    GO:0006473protein acetylation IDA12750254
    GO:0006915apoptotic process IDA15251430
    GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA16387653

    ING4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ING4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ING4 gene (7 alternative transcripts): 
    NM_001127582.1  NM_001127583.1  NM_001127584.1  NM_001127585.1  NM_001127586.1  NM_016162.3  NM_198287.1  

    Unigene Cluster for ING4:

    Inhibitor of growth family, member 4
    Hs.524210  [show with all ESTs]
    Unigene Representative Sequence: BC095434
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341550(uc001qpv.4 uc001qpw.4 uc001qpy.4 uc001qpx.4 uc009zes.3 uc009zet.3 uc009zeu.3 uc009zev.3)
    ENST00000396807 ENST00000446105 ENST00000486287 ENST00000484795 ENST00000482489
    ENST00000469749 ENST00000472002 ENST00000488381 ENST00000423703 ENST00000412586
    ENST00000444704 ENST00000437149 ENST00000467678 ENST00000479301 ENST00000493873
    ENST00000493267
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ING4 (see all 10):
    hsa-miR-3065-3p hsa-miR-3120-3p hsa-miR-650 hsa-miR-548g hsa-miR-214 hsa-miR-2116* hsa-miR-3154 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidING4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ING4
    Clone
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    OriGene clones in human, mouse for ING4 (see all 32)
    OriGene ORF clones in mouse, rat for ING4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): ING4 (NM_001127582)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING4
    Primer
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    OriGene qPCR primer pairs and template standards for ING4
    OriGene qSTAR qPCR primer pairs in human, mouse for ING4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ING4
      QuantiTect SYBR Green Assays in human, mouse, rat ING4
      QuantiFast Probe-based Assays in human, mouse, rat ING4

    Additional mRNA sequence: 

    AB197695.1 AB197696.1 AB197697.1 AF063594.1 AF110645.1 AF156552.1 AK293169.1 AK303354.1 
    AK313621.1 BC007781.2 BC013038.2 BC095434.1 EF152349.1 EF152350.1 EF152351.1 EF152352.1 

    14 DOTS entries:

    DT.444794  DT.100813613  DT.417440  DT.92429632  DT.100669859  DT.40121290  DT.121171421  DT.95073601 
    DT.100799981  DT.100813607  DT.121171423  DT.95105352  DT.95105354  DT.92064217 

    Selected AceView cDNA sequences (see all 225):

    AA130216 BQ017358 AL534106 BG742312 AI081362 CD108916 BM970448 AF156552 
    BE350257 AI472417 BM724484 BU627656 CA445104 BF434392 BQ575730 CR596785 
    AW629657 AA504961 BX421859 CB850518 CB119734 W24291 CB119731 BF513966 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ING4 (see all 22)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ·
    SP1:        -           -     -                                   -           -                                                                                 
    SP2:        -           -     -                                   -           -                                                                                 
    SP3:        -           -     -                             -     -           -                                                                                 
    SP4:        -     -     -     -                                   -           -                                                                                 
    SP5:                    -     -                             -     -           -                                                                                 

    ExUns: 11h
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ING4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ING4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ING4 Expression
    About this image

    ING4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ING4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524210
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ING4: 
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ING4
    OriGene qSTAR qPCR primer pairs in human, mouse for ING4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ING4
    QuantiTect SYBR Green Assays in human, mouse, rat ING4
    QuantiFast Probe-based Assays in human, mouse, rat ING4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ING4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ing41 , 5 inhibitor of growth family, member 41, 5 92.95(n)1
    96.75(a)1
      6 (59.17 cM)5
    280191  NM_133345.21  NP_579923.11 
     1250397605 
    chicken
    (Gallus gallus)
    Aves ING41 inhibitor of growth family, member 4 79.81(n)
    93.9(a)
      418281  NM_001006251.1  NP_001006251.1 
    lizard
    (Anolis carolinensis)
    Reptilia ING46
    inhibitor of growth family, member 4
    97(a)
    1 ↔ 1
    GL343381.1(851941-859943)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ing41 inhibitor of growth family, member 4 76.19(n)
    86.53(a)
      100491241  XM_004915767.1  XP_004915824.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb11d092 Transcribed sequence with moderate similarity to protein more 79(n)    57043060 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92931 , 3 CG92931 42(a)3
    58.67(n)1
    56.1(a)1
      34B93
    347521  NM_135803.31  NP_609647.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO236
    Probable component of the Rpd3 histone deacetylase...
    19(a)
    1 → many
    XIV(441366-442358) YNL097C
    barley
    (Hordeum vulgare)
    Liliopsida AJ472374.12   -- 73.77(n)    AJ472374.1 


    ENSEMBL Gene Tree for ING4 (if available)
    TreeFam Gene Tree for ING4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ING4 gene
    ING22  ING52  ING32  ING12  
    4 SIMAP similar genes for ING4 using alignment to 7 protein entries:     ING4_HUMAN (see all proteins):
    ING5    ING3    ING2    ING1

    ING4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ING4 (see all 322)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872115361,2
    C--6759254(+) CTCTAA/CTAAAA 6 -- ds50010--------
    rs1475341831,2
    C--6759347(+) GGAGGC/TGGAGA 6 -- ds50010--------
    rs1402422011,2
    --6759348(+) GAGGCA/GGAGAC 6 -- ds50010--------
    rs1920964611,2
    --6759454(+) AGTATA/GGCAGT 6 -- ds50010--------
    rs1809527131,2
    --6759506(+) TGAAAC/GATGTT 6 -- ds50010--------
    rs79619401,2
    C,F,H--6759568(+) AGGCCC/TACCCT 6 -- ds500124Minor allele frequency- T:0.06NS EA NA WA CSA 1873
    rs110643011,2
    C--6759645(+) CATGTC/TGTGTC 6 -- ds5001 ese30--------
    rs740570511,2
    C,F--6759646(+) ATGTCG/ATGTCC 6 -- ds50012Minor allele frequency- A:0.15WA 120
    rs79620471,2
    C,H--6759679(+) CACATC/TGCATC 6 -- ds5001 ese314Minor allele frequency- T:0.01NA WA CSA EA 377
    rs1455322741,2
    C--6759934(+) GGAAGA/GGAATG 6 -- ut310--------

    HapMap Linkage Disequilibrium report for ING4 (6759446 - 6772314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ING4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509452CNV Insertion20534489
    nsv898635CNV Loss21882294
    nsv832323CNV Loss17160897
    nsv832322CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ING4
    DNA2.0 Custom Variant and Variant Library Synthesis for ING4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608524    OMIM disorders: --

    17 diseases for ING4:    
    About MalaCards
    cryptogenic organizing pneumonia    lung adenocarcinoma    gastric adenocarcinoma    pneumonia
    hypoxia    pulmonary fibrosis    sarcoidosis    astrocytoma
    adenocarcinoma    myeloma    colorectal cancer    lung cancer
    squamous cell carcinoma    melanoma    breast cancer    hepatocellular carcinoma
    endotheliitis


    ING4 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ING4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 23.1 16 15935570 (4), 16096374 (3), 18789575 (3), 19571607 (2) (see all 7)


    Export disorders for ING4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ING4 gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with ING4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. (PubMed id 12750254)1, 2, 3, 9 Shiseki M....Harris C.C. (Cancer Res. 2003)
    2. Nuclear localization signal of ING4 plays a key role in its binding to p53. (PubMed id 15882981)1, 2, 9 Zhang X....Han Z.G. (Biochem. Biophys. Res. Commun. 2005)
    3. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. (PubMed id 15029197)1, 2, 9 Garkavtsev I.... Jain R.K. (Nature 2004)
    4. Crystal structure of inhibitor of growth 4 (ING4) dimerization domain reveals functional organization of ING family of chromatin-binding proteins. (PubMed id 22334692)1, 2 Culurgioni S.... Blanco F.J. (J. Biol. Chem. 2012)
    5. Citrullination of inhibitor of growth 4 (ING4) by peptidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53. (PubMed id 21454715)1, 2 Guo Q. and Fast W. (J. Biol. Chem. 2011)
    6. Molecular basis of histone H3K4me3 recognition by ING4. (PubMed id 18381289)1, 2 Palacios A.... Blanco F.J. (J. Biol. Chem. 2008)
    7. Detection of novel mRNA splice variants of human ING4 tumor suppressor gene. (PubMed id 17325660)1, 2 Raho G.... Greco A. (Oncogene 2007)
    8. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. (PubMed id 16728974)1, 2 Shi X.... Gozani O. (Nature 2006)
    9. Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility. (PubMed id 16973615)1, 2 Unoki M.... Harris C.C. (J. Biol. Chem. 2006)
    10. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2 Doyon Y.... Cote J. (Mol. Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51147 HGNC: 19423 AceView: ING4 Ensembl:ENSG00000111653 euGenes: HUgn51147
    ECgene: ING4 H-InvDB: ING4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ING4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ING4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ING4 gene:
    Search GeneIP for patents involving ING4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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