Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ING3 Gene

Aliases for ING3 Gene

  • Inhibitor Of Growth Family, Member 3 2 3
  • P47ING3 3 4
  • Inhibitor Of Growth Protein 3 3
  • MEAF4 3
  • Eaf4 3
  • ING2 3
  • P47 6

External Ids for ING3 Gene

Previous GeneCards Identifiers for ING3 Gene

  • GC07P119068
  • GC07P120131
  • GC07P120145
  • GC07P120184
  • GC07P120378
  • GC07P120590
  • GC07P114954

Summaries for ING3 Gene

Entrez Gene Summary for ING3 Gene

  • The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for ING3 Gene

ING3 (Inhibitor Of Growth Family, Member 3) is a Protein Coding gene. Diseases associated with ING3 include squamous cell carcinoma, head and neck. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include histone acetyltransferase activity and methylated histone binding. An important paralog of this gene is ING4.

UniProtKB/Swiss-Prot for ING3 Gene

  • Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Gene Wiki entry for ING3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ING3 Gene

Genomics for ING3 Gene

Regulatory Elements for ING3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ING3 Gene

Start:
120,950,749 bp from pter
End:
120,977,216 bp from pter
Size:
26,468 bases
Orientation:
Plus strand

Genomic View for ING3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ING3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ING3 Gene

Proteins for ING3 Gene

  • Protein details for ING3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXR8-ING3_HUMAN
    Recommended name:
    Inhibitor of growth protein 3
    Protein Accession:
    Q9NXR8
    Secondary Accessions:
    • A8K790
    • O60394
    • Q567P3
    • Q6GMT3
    • Q7Z762
    • Q969G0
    • Q96DT4
    • Q9HC99
    • Q9P081

    Protein attributes for ING3 Gene

    Size:
    418 amino acids
    Molecular mass:
    46743 Da
    Quaternary structure:
    • Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. Component of a SWR1-like complex.
    SequenceCaution:
    • Sequence=AAF28979.1; Type=Frameshift; Positions=90; Evidence={ECO:0000305}; Sequence=AAH73865.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ING3 Gene

    Alternative splice isoforms for ING3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ING3 Gene

Proteomics data for ING3 Gene at MOPED

Post-translational modifications for ING3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ING3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ING3 Gene

Domains for ING3 Gene

Gene Families for ING3 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

Suggested Antigen Peptide Sequences for ING3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXR8

UniProtKB/Swiss-Prot:

ING3_HUMAN :
  • Q9NXR8
Domain:
  • The PHD-type zinc finger mediates the binding to H3K4me3.
Family:
  • Belongs to the ING family.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with ING3: view

Function for ING3 Gene

Molecular function for ING3 Gene

UniProtKB/Swiss-Prot Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Gene Ontology (GO) - Molecular Function for ING3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004402 contributes_to histone acetyltransferase activity IDA 14966270
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0035064 methylated histone binding IDA 16728974
genes like me logo Genes that share ontologies with ING3: view

Animal Model Products

CRISPR Products

miRNA for ING3 Gene

miRTarBase miRNAs that target ING3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ING3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ING3 Gene

Localization for ING3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ING3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ING3 Gene COMPARTMENTS Subcellular localization image for ING3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ING3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ING3: view

Pathways for ING3 Gene

genes like me logo Genes that share pathways with ING3: view

Pathways by source for ING3 Gene

1 BioSystems pathway for ING3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Modification Enzymes in human,mouse,rat
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat

Gene Ontology (GO) - Biological Process for ING3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016568 chromatin modification --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with ING3: view

Transcripts for ING3 Gene

Unigene Clusters for ING3 Gene

Inhibitor of growth family, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ING3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ING3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ING3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for ING3 Gene

GeneLoc Exon Structure for
ING3
ECgene alternative splicing isoforms for
ING3

Expression for ING3 Gene

mRNA expression in normal human tissues for ING3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ING3 Gene

SOURCE GeneReport for Unigene cluster for ING3 Gene Hs.489811

mRNA Expression by UniProt/SwissProt for ING3 Gene

Q9NXR8-ING3_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus
genes like me logo Genes that share expressions with ING3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ING3 Gene

Orthologs for ING3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ING3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ING3 35
  • 99.92 (n)
  • 100 (a)
ING3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ING3 35
  • 92.26 (n)
  • 98.09 (a)
ING3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ING3 35
  • 93.7 (n)
  • 99.04 (a)
ING3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ing3 35
  • 87.4 (n)
  • 95.93 (a)
Ing3 16
Ing3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ING3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ING3 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ing3 35
  • 88.2 (n)
  • 97.13 (a)
chicken
(Gallus gallus)
Aves ING3 35
  • 82.57 (n)
  • 92.09 (a)
ING3 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ING3 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ing3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ing3 35
  • 78.88 (n)
  • 88.43 (a)
zebrafish
(Danio rerio)
Actinopterygii ing3 35
  • 73.62 (n)
  • 84.47 (a)
ing3 36
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ing3 36
  • 29 (a)
OneToOne
CG6632 37
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea ing-3 36
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNG1 38
YNG2 36
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ING1 35
  • 53.02 (n)
  • 46.2 (a)
rice
(Oryza sativa)
Liliopsida Os03g0143600 35
  • 52.08 (n)
  • 49.43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1861 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for ING3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ING3 Gene

ENSEMBL:
Gene Tree for ING3 (if available)
TreeFam:
Gene Tree for ING3 (if available)

Paralogs for ING3 Gene

Paralogs for ING3 Gene

Selected SIMAP similar genes for ING3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ING3: view

Variants for ING3 Gene

Sequence variations from dbSNP and Humsavar for ING3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs13881 -- 120,975,956(+) TTTGA(C/T)TGGAG downstream-variant-500B
rs2074576 -- 120,970,578(+) GCTTA(C/G)ACTTT intron-variant
rs2074577 -- 120,971,109(+) TTGGT(A/G)TACCA intron-variant
rs2189544 -- 120,974,361(+) CAGCA(A/G)ATAAG intron-variant
rs2248890 -- 120,957,939(+) TACTG(A/G)AGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ING3 Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
nsv831114 CNV Loss 17160897

Relevant External Links for ING3 Gene

HapMap Linkage Disequilibrium report
ING3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ING3 Gene

Disorders for ING3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ING3 Gene including...

Search for ING3 Gene in MalaCards »

UniProtKB/Swiss-Prot

ING3_HUMAN
  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. {ECO:0000269 PubMed:12080476}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

(1) Novoseek inferred disease relationships for ING3 Gene

Disease -log(P) Hits PubMed IDs
tumors 33.3 6

Relevant External Links for ING3

Genetic Association Database (GAD)
ING3
Human Genome Epidemiology (HuGE) Navigator
ING3
genes like me logo Genes that share disorders with ING3: view

Publications for ING3 Gene

  1. A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis. (PMID: 12545155) Nagashima M. … Harris C.C. (Oncogene 2003) 3 4 23
  2. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. (PMID: 12080476) Gunduz M. … Shimizu K. (Oncogene 2002) 2 3 4
  3. Arabidopsis ING and Alfin1-like protein families localize to the nucleus and bind to H3K4me3/2 via plant homeodomain fingers. (PMID: 19154204) Lee W.Y. … Kwon C.S. (Plant J. 2009) 3 4
  4. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PMID: 16387653) Doyon Y. … Cote J. (Mol. Cell 2006) 3 4
  5. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. (PMID: 16728974) Shi X. … Gozani O. (Nature 2006) 3 4

Products for ING3 Gene

Sources for ING3 Gene

Back to Top

Content