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Aliases for ING3 Gene

Aliases for ING3 Gene

  • Inhibitor Of Growth Family Member 3 2 3 5
  • P47ING3 3 4
  • Inhibitor Of Growth Protein 3 3
  • MEAF4 3
  • Eaf4 3
  • ING2 3

External Ids for ING3 Gene

Previous GeneCards Identifiers for ING3 Gene

  • GC07P119068
  • GC07P120131
  • GC07P120145
  • GC07P120184
  • GC07P120378
  • GC07P120590
  • GC07P114954

Summaries for ING3 Gene

Entrez Gene Summary for ING3 Gene

  • The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for ING3 Gene

ING3 (Inhibitor Of Growth Family Member 3) is a Protein Coding gene. Diseases associated with ING3 include Squamous Cell Carcinoma, Head And Neck and Breast Adenoma. Among its related pathways are Chromatin organization. GO annotations related to this gene include histone acetyltransferase activity and methylated histone binding. An important paralog of this gene is ING4.

UniProtKB/Swiss-Prot for ING3 Gene

  • Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Gene Wiki entry for ING3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ING3 Gene

Genomics for ING3 Gene

Regulatory Elements for ING3 Gene

Enhancers for ING3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G120987 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +40.1 40113 7.1 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT WRNIP1 SIN3A DMAP1 ZNF2 YY1 TSPAN12 ING3 CPED1 HMGN1P18
GH07G121081 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +133.9 133858 6.3 HNRNPUL1 HDGF PKNOX1 ATF1 ARNT AGO1 SIN3A ZNF2 FOS KLF13 CPED1 ING3 RNA5SP241 GC07M121084 GC07P121089
GH07G121075 1.5 Ensembl ENCODE dbSUPER 11.3 +126.0 125964 1.8 PKNOX1 ATF1 CREB3L1 ARNT TCF12 ZNF766 ELK1 GATA2 FOS JUNB CPED1 ING3 GC07M121084 RNA5SP241 HMGN1P18
GH07G121018 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.8 +69.3 69293 2.8 FOXA2 ATF1 ZNF133 ZBTB40 CHAMP1 YY1 EGR1 FOS ZNF174 ZNF362 TSPAN12 ING3 CPED1 HMGN1P18
GH07G121077 1 dbSUPER 11.3 +128.4 128409 2.7 HDGF PKNOX1 ARNT YY1 ZNF766 ZNF592 CREB3 SMARCA4 MYNN NBN CPED1 ING3 GC07M121084 RNA5SP241 HMGN1P18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ING3 on UCSC Golden Path with GeneCards custom track

Promoters for ING3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000217360 51 2001 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for ING3 Gene

Chromosome:
7
Start:
120,950,749 bp from pter
End:
120,977,216 bp from pter
Size:
26,468 bases
Orientation:
Plus strand

Genomic View for ING3 Gene

Genes around ING3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ING3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ING3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ING3 Gene

Proteins for ING3 Gene

  • Protein details for ING3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXR8-ING3_HUMAN
    Recommended name:
    Inhibitor of growth protein 3
    Protein Accession:
    Q9NXR8
    Secondary Accessions:
    • A8K790
    • O60394
    • Q567P3
    • Q6GMT3
    • Q7Z762
    • Q969G0
    • Q96DT4
    • Q9HC99
    • Q9P081

    Protein attributes for ING3 Gene

    Size:
    418 amino acids
    Molecular mass:
    46743 Da
    Quaternary structure:
    • Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. Component of a SWR1-like complex.
    SequenceCaution:
    • Sequence=AAF28979.1; Type=Frameshift; Positions=90; Evidence={ECO:0000305}; Sequence=AAH73865.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ING3 Gene

    Alternative splice isoforms for ING3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ING3 Gene

Post-translational modifications for ING3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ING3 Gene

No data available for DME Specific Peptides for ING3 Gene

Domains & Families for ING3 Gene

Gene Families for ING3 Gene

Suggested Antigen Peptide Sequences for ING3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXR8

UniProtKB/Swiss-Prot:

ING3_HUMAN :
  • The PHD-type zinc finger mediates the binding to H3K4me3.
  • Belongs to the ING family.
Domain:
  • The PHD-type zinc finger mediates the binding to H3K4me3.
Family:
  • Belongs to the ING family.
genes like me logo Genes that share domains with ING3: view

Function for ING3 Gene

Molecular function for ING3 Gene

UniProtKB/Swiss-Prot Function:
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Gene Ontology (GO) - Molecular Function for ING3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004402 contributes_to histone acetyltransferase activity IDA 14966270
GO:0005515 protein binding IPI --
GO:0008270 zinc ion binding IEA --
GO:0035064 methylated histone binding IDA 16728974
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ING3: view

Phenotypes for ING3 Gene

genes like me logo Genes that share phenotypes with ING3: view

Animal Model Products

CRISPR Products

miRNA for ING3 Gene

miRTarBase miRNAs that target ING3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ING3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ING3 Gene

Localization for ING3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ING3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ING3 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ING3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus IDA,IEA --
GO:0005654 nucleoplasm TAS --
GO:0032777 Piccolo NuA4 histone acetyltransferase complex IDA 14966270
GO:0035267 NuA4 histone acetyltransferase complex IDA 14966270
genes like me logo Genes that share ontologies with ING3: view

Pathways & Interactions for ING3 Gene

genes like me logo Genes that share pathways with ING3: view

Pathways by source for ING3 Gene

Gene Ontology (GO) - Biological Process for ING3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016569 covalent chromatin modification IEA --
GO:0040008 regulation of growth IEA --
GO:0043065 positive regulation of apoptotic process IDA 16387653
genes like me logo Genes that share ontologies with ING3: view

No data available for SIGNOR curated interactions for ING3 Gene

Drugs & Compounds for ING3 Gene

No Compound Related Data Available

Transcripts for ING3 Gene

Unigene Clusters for ING3 Gene

Inhibitor of growth family, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ING3

Alternative Splicing Database (ASD) splice patterns (SP) for ING3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for ING3 Gene

GeneLoc Exon Structure for
ING3
ECgene alternative splicing isoforms for
ING3

Expression for ING3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ING3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ING3 Gene

This gene is overexpressed in Fetal Brain (19.1), CD8 Tcells (18.6), and Peripheral blood mononuclear cells (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ING3 Gene



Protein tissue co-expression partners for ING3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ING3 Gene:

ING3

SOURCE GeneReport for Unigene cluster for ING3 Gene:

Hs.489811

mRNA Expression by UniProt/SwissProt for ING3 Gene:

Q9NXR8-ING3_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.

Evidence on tissue expression from TISSUES for ING3 Gene

  • Lung(4.4)
  • Blood(4.3)
  • Liver(4.2)
  • Muscle(4.2)
  • Pancreas(4.1)
  • Lymph node(2.2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with ING3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ING3 Gene

Orthologs for ING3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ING3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ING3 34 35
  • 99.92 (n)
dog
(Canis familiaris)
Mammalia ING3 34 35
  • 93.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ING3 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ING3 34 35
  • 92.26 (n)
rat
(Rattus norvegicus)
Mammalia Ing3 34
  • 88.2 (n)
mouse
(Mus musculus)
Mammalia Ing3 34 16 35
  • 87.4 (n)
oppossum
(Monodelphis domestica)
Mammalia ING3 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ING3 34 35
  • 82.57 (n)
lizard
(Anolis carolinensis)
Reptilia ING3 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ing3 34
  • 78.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia ing3-prov 34
zebrafish
(Danio rerio)
Actinopterygii ing3 34 35
  • 73.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6632 36
  • 62 (a)
Ing3 35
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ing-3 35
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNG2 35
  • 25 (a)
OneToOne
YNG1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons ING1 34
  • 53.02 (n)
rice
(Oryza sativa)
Liliopsida Os03g0143600 34
  • 52.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1861 34
Species where no ortholog for ING3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ING3 Gene

ENSEMBL:
Gene Tree for ING3 (if available)
TreeFam:
Gene Tree for ING3 (if available)

Paralogs for ING3 Gene

Paralogs for ING3 Gene

(3) SIMAP similar genes for ING3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ING3: view

Variants for ING3 Gene

Sequence variations from dbSNP and Humsavar for ING3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_021263 Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]
rs1000154375 -- 120,949,897(+) TATAT(C/T)ACAGG upstream-variant-2KB
rs1000206236 -- 120,950,066(+) TGAAG(-/ATT)ATTAT upstream-variant-2KB
rs1000303065 -- 120,956,622(+) AAAAT(G/T)TCATA intron-variant, utr-variant-3-prime
rs1000310117 -- 120,950,675(+) GCCGG(G/T)CTACG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ING3 Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER inversion 18451855
nsv831114 CNV loss 17160897

Variation tolerance for ING3 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ING3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ING3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ING3 Gene

Disorders for ING3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ING3 Gene - From: Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
squamous cell carcinoma, head and neck
  • squamous cell carcinoma, head and neck, somatic
breast adenoma
  • ademoma - breast
pneumatosis cystoides intestinalis
- elite association - COSMIC cancer census association via MalaCards
Search ING3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ING3_HUMAN
  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. {ECO:0000269 PubMed:12080476}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Relevant External Links for ING3

Genetic Association Database (GAD)
ING3
Human Genome Epidemiology (HuGE) Navigator
ING3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ING3
genes like me logo Genes that share disorders with ING3: view

No data available for Genatlas for ING3 Gene

Publications for ING3 Gene

  1. A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis. (PMID: 12545155) Nagashima M. … Harris C.C. (Oncogene 2003) 3 4 22 64
  2. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. (PMID: 12080476) Gunduz M. … Shimizu K. (Oncogene 2002) 2 3 4 64
  3. ANP32E is a histone chaperone that removes H2A.Z from chromatin. (PMID: 24463511) Obri A. … Hamiche A. (Nature 2014) 3 4 64
  4. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3 46 64
  5. Arabidopsis ING and Alfin1-like protein families localize to the nucleus and bind to H3K4me3/2 via plant homeodomain fingers. (PMID: 19154204) Lee W.Y. … Kwon C.S. (Plant J. 2009) 3 4 64

Products for ING3 Gene

  • Addgene plasmids for ING3

Sources for ING3 Gene

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