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ING3 Gene

protein-coding   GIFtS: 60
GCID: GC07P120590

Inhibitor Of Growth Family, Member 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inhibitor Of Growth Family, Member 31 2     MEAF42
p47ING32 3     Inhibitor Of Growth Protein 32
Eaf42     P475
ING22     

External Ids:    HGNC: 145871   Entrez Gene: 545562   Ensembl: ENSG000000712437   OMIM: 6074935   UniProtKB: Q9NXR83   

Export aliases for ING3 gene to outside databases

Previous GC identifers: GC07P119068 GC07P120131 GC07P120145 GC07P120184 GC07P120378 GC07P114954


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ING3 Gene:
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53,
inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in
proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including
promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce
apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two
alternatively spliced transcript variants encoding different isoforms have been observed. (provided by RefSeq,
Jul 2008)

GeneCards Summary for ING3 Gene:
ING3 (inhibitor of growth family, member 3) is a protein-coding gene. Diseases associated with ING3 include squamous cell carcinoma of the head and neck, and eaf. GO annotations related to this gene include histone acetyltransferase activity and methylated histone residue binding. An important paralog of this gene is ING2.

UniProtKB/Swiss-Prot: ING3_HUMAN, Q9NXR8
Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional
activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may
both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins
which positively regulate transcription. This complex may be required for the activation of transcriptional
programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth
arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when
directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the
removal of histone H2A.Z/H2AFZ from the nucleosome

Gene Wiki entry for ING3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ING3 gene promoter:
         E2F-3a   E2F-4   E2F-5   Pbx1a   E2F-2   S8   E2F-1   E2F   Meis-1a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ING3 promoter sequence
   Search Chromatin IP Primers for ING3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ING3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31   Ensembl cytogenetic band:  7q31.31   HGNC cytogenetic band: 7q31

ING3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ING3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P120590:  view genomic region     (about GC identifiers)

Start:
120,590,803 bp from pter      End:
120,617,270 bp from pter
Size:
26,468 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 119,985,911-120,010,805     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ING3_HUMAN, Q9NXR8 (See protein sequence)
Recommended Name: Inhibitor of growth protein 3  
Size: 418 amino acids; 46743 Da
Subunit: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone
acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400,
BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX,
MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein.
HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. Component of a
SWR1-like complex
Sequence caution: Sequence=AAF28979.1; Type=Frameshift; Positions=90; Sequence=AAH73865.1; Type=Miscellaneous
discrepancy; Note=Intron retention;
1 PDB 3D structure from and Proteopedia for ING3:
1X4I (3D)    
Secondary accessions: A8K790 O60394 Q567P3 Q6GMT3 Q7Z762 Q969G0 Q96DT4 Q9HC99 Q9P081
Alternative splicing: 3 isoforms:  Q9NXR8-1   Q9NXR8-2   Q9NXR8-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ING3: NX_Q9NXR8

Explore proteomics data for ING3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ING3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_061944.2  NP_938008.1  

    ENSEMBL proteins: 
     ENSP00000320566   ENSP00000341697   ENSP00000410406   ENSP00000395719   ENSP00000388506  
    Reactome Protein details: Q9NXR8

    ING3 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ING3

    ING3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Antibodies for ING3
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    Novus Biologicals ING3 Antibody
    Abcam antibodies for ING3
    Cloud-Clone Corp. Antibodies for ING3
    ThermoFisher Antibodies for ING3
    LSBio Antibodies in human, mouse, rat for ING3

    ING3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ING3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ING3
    Cloud-Clone Corp. CLIAs for ING3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 8):
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR028651 ING_fam
     IPR028645 ING3
     IPR024610 ING_N

    Graphical View of Domain Structure for InterPro Entry Q9NXR8

    ProtoNet protein and cluster: Q9NXR8

    1 Blocks protein domain: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: ING3_HUMAN, Q9NXR8
    Domain: The PHD-type zinc finger mediates the binding to H3K4me3
    Similarity: Belongs to the ING family
    Similarity: Contains 1 PHD-type zinc finger


    ING3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ING3_HUMAN, Q9NXR8
    Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional
    activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may
    both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins
    which positively regulate transcription. This complex may be required for the activation of transcriptional
    programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth
    arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when
    directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the
    removal of histone H2A.Z/H2AFZ from the nucleosome

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004402contributes to histone acetyltransferase activity IDA14966270
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0035064methylated histone residue binding IDA16728974
         
    ING3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ING3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ING3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ING3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ING3

    miRNA
    Products:
        
    miRTarBase miRNAs that target ING3:
    hsa-mir-378a-5p (MIRT043992)

    Block miRNA regulation of human, mouse, rat ING3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ING3 (see all 33):
    hsa-miR-596 hsa-miR-142-5p hsa-miR-3910 hsa-miR-448 hsa-miR-4288 hsa-miR-632 hsa-miR-181a-2* hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidING3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ING3
    Predesigned siRNA for gene silencing in human, mouse, rat ING3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ING3

    Clone
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    OriGene clones in human, mouse for ING3 (see all 12)
    OriGene ORF clones in mouse, rat for ING3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ING3 (NM_019071)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ING3
    Browse ESI BIO Cell Lines and PureStem Progenitors for ING3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ING3_HUMAN, Q9NXR8: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000812Swr1 complex IDA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    ING3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ING3 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ING3
        HATs acetylate histones



    ING3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ING3: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ING3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ING3 (Q9NXR83 ENSP000003205664) via UniProtKB, MINT, STRING, and/or I2D (see all 291)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H3F3AP842433, ENSP000003557784I2D: score=2 STRING: ENSP00000355778
    H3F3BP842433, ENSP000002548104I2D: score=2 STRING: ENSP00000254810
    DHX37Q8IY373, ENSP000003111354I2D: score=4 STRING: ENSP00000311135
    DMAP1Q9NPF53, ENSP000003126974I2D: score=4 STRING: ENSP00000312697
    MORF4L1Q9UBU83, ENSP000003313104I2D: score=4 STRING: ENSP00000331310
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0040008regulation of growth IEA--
    GO:0043065positive regulation of apoptotic process IDA16387653

    ING3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ING3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ING3 gene (3 alternative transcripts): 
    NM_019071.2  NM_198267.1  NM_198266.1  

    Unigene Cluster for ING3:

    Inhibitor of growth family, member 3
    Hs.489811  [show with all ESTs]
    Unigene Representative Sequence: NM_019071
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315870(uc003vjn.3 uc003vjo.3 uc003vjp.3 uc011kns.2)
    ENST00000339121(uc011knr.1 uc003vjm.1) ENST00000427726 ENST00000445699(uc003vjl.3)
    ENST00000431467 ENST00000497502
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ING3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ING3 (see all 33):
    hsa-miR-596 hsa-miR-142-5p hsa-miR-3910 hsa-miR-448 hsa-miR-4288 hsa-miR-632 hsa-miR-181a-2* hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidING3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ING3
    Predesigned siRNA for gene silencing in human, mouse, rat ING3
    Clone
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    OriGene clones in human, mouse for ING3 (see all 12)
    OriGene ORF clones in mouse, rat for ING3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ING3 (NM_019071)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ING3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ING3
      QuantiTect SYBR Green Assays in human, mouse, rat ING3
      QuantiFast Probe-based Assays in human, mouse, rat ING3

    Additional mRNA sequence: 

    AF074968.1 AF161419.1 AF180298.1 AK000096.1 AK291905.1 AK293682.1 AY007790.1 BC009776.1 
    BC009777.1 BC010851.1 BC062634.1 BC073865.1 BC093091.1 BC093689.1 BC101609.1 BC143316.1 

    9 DOTS entries:

    DT.443169  DT.453271  DT.312049  DT.95173727  DT.95173730  DT.91754837  DT.95353265  DT.100913559 
    DT.121041811 

    Selected AceView cDNA sequences (see all 157):

    BF792005 AI216055 BG435269 BI861001 AA714651 AA251773 AA280851 AI129337 
    AA280947 NM_019071 BC073865 BG574907 BC062634 CR621026 AA935593 CR598359 
    BC009776 BM458202 AA468552 NM_198266 AA768602 CB159730 AA173556 BE503566 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ING3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                      -     -                 -                                       
    SP2:                                      -     -     -           -                                       
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for ING3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ING3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGAGGGGG
    ING3 Expression
    About this image


    ING3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
    ING3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ING3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.489811

    UniProtKB/Swiss-Prot: ING3_HUMAN, Q9NXR8
    Tissue specificity: Expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle,
    small intestine, spleen, testis and thymus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ING3: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ING3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ING3
    QuantiTect SYBR Green Assays in human, mouse, rat ING3
    QuantiFast Probe-based Assays in human, mouse, rat ING3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ING3 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ing31 , 5 inhibitor of growth family, member 31, 5 87.4(n)1
    95.93(a)1
      6 (8.81 cM)5
    717771  NM_023626.41  NP_076115.31 
     219495715 
    chicken
    (Gallus gallus)
    Aves ING31 inhibitor of growth family, member 3 82.57(n)
    92.09(a)
      417762  NM_001030733.1  NP_001025904.1 
    lizard
    (Anolis carolinensis)
    Reptilia ING36
    inhibitor of growth family, member 3
    90(a)
    1 ↔ 1
    5(63574169-63595894)
    African clawed frog
    (Xenopus laevis)
    Amphibia ing3-prov2 inhibitor of growth family, member 3 80.11(n)    BC045263.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ing32 inhibitor of growth family, member 3 77.84(n)   393911  AY423027.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66323   -- 62(a)   17C7   --
    worm
    (Caenorhabditis elegans)
    Secernentea ing-36
    Protein ING-3 (ing-3) mRNA, complete cds
    20(a)
    1 ↔ 1
    II(13876034-13882587) WBGene00013095
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YNG1(YOR064C)4 Subunit of the NuA3 histone acetyltransferase complex more   --   15(446738-446079) 854230  NP_014707.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ING11 ING1 53.02(n)
    46.2(a)
      821986  NM_113306.3  NP_566742.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01436001 Os03g0143600 52.08(n)
    49.43(a)
      4331591  NM_001055474.1  NP_001048939.1 


    ENSEMBL Gene Tree for ING3 (if available)
    TreeFam Gene Tree for ING3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ING3 gene
    ING22  ING42  ING52  ING12  
    3 SIMAP similar genes for ING3 using alignment to 3 protein entries:     ING3_HUMAN (see all proteins):
    ING2    ING4    ING5

    ING3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ING3 (see all 527)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0212634
    Squamous cell carcinoma of the head and neck (HNSCC)4--see VAR_0212632 D G mis40--------
    rs339477041,2
    C--119985881(+) CGCCT-/GCAGGC 2 -- us2k10--------
    rs743208771,2
    C--120613536(+) GTTAT-/AT/TA 
            
    GTTGT
    1 -- int10--------
    rs615538271,2
    C--120615330(+) AAAAA-/A/AA  
            
    GTCAG
    2 -- ut310--------
    rs1921579091,2
    --123937807(+) CTCAAA/GGAATC 2 -- us2k10--------
    rs1845243321,2
    --123937857(+) AAATCA/GCAACC 2 -- us2k10--------
    rs117709911,2
    C,H--123937915(+) TAGCAC/GTAAAA 2 -- us2k1 tfbs34Minor allele frequency- G:0.00NS EA 414
    rs1413809681,2
    --123937977(+) ATAATC/TTGTAT 2 -- us2k10--------
    rs1132446431,2
    C--123938097(+) GAATAA/CAGAGA 2 -- us2k13Minor allele frequency- C:0.03WA EA 240
    rs1469708021,2
    --123938124(+) AAAATG/TAGAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ING3 (120590803 - 120617270 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ING3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831114CNV Loss17160897
    nsv7405OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ING3
    DNA2.0 Custom Variant and Variant Library Synthesis for ING3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607493    OMIM disorders: --

    UniProtKB/Swiss-Prot: ING3_HUMAN, Q9NXR8
  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting
    the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
    Note=The disease may be caused by mutations affecting the gene represented in this entry

  • 10 diseases for ING3:    
    About MalaCards
    squamous cell carcinoma of the head and neck    eaf    squamous cell carcinoma    hepatocellular carcinoma
    melanoma    thyroiditis    lung cancer    multiple myeloma
    myeloma    prostatitis


    ING3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ING3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 33.3 7 18160212 (3), 16465410 (2), 15935570 (1)

    Genetic Association Database (GAD): ING3
    Human Genome Epidemiology (HuGE) Navigator: ING3 (1 document)

    Export disorders for ING3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ING3 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with ING3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. (PubMed id 12080476)1, 2, 3 Gunduz M.... Shimizu K. (Oncogene 2002)
    2. A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis. (PubMed id 12545155)1, 2, 9 Nagashima M.... Harris C.C. (Oncogene 2003)
    3. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (Mol. Psychiatry 2010)
    4. Arabidopsis ING and Alfin1-like protein families localize to the nucleus and bind to H3K4me3/2 via plant homeodomain fingers. (PubMed id 19154204)1, 2 Lee W.Y.... Kwon C.S. (Plant J. 2009)
    5. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. (PubMed id 16728974)1, 2 Shi X.... Gozani O. (Nature 2006)
    6. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2 Doyon Y.... Cote J. (Mol. Cell 2006)
    7. The highly conserved and multifunctional NuA4 HAT complex. (PubMed id 15196461)1, 2 Doyon Y. and Cote J. (Curr. Opin. Genet. Dev. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. (PubMed id 14966270)1, 2 Doyon Y.... Cote J. (Mol. Cell. Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54556 HGNC: 14587 AceView: ING3 Ensembl:ENSG00000071243 euGenes: HUgn54556
    ECgene: ING3 H-InvDB: ING3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ING3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ING3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ING3 gene:
    Search GeneIP for patents involving ING3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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