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Aliases for ING2 Gene

Aliases for ING2 Gene

  • Inhibitor Of Growth Family, Member 2 2 3
  • ING1L 3 4 6
  • Inhibitor Of Growth 1-Like Protein 3 4
  • P33ING2 3 4
  • ING1Lp 3 4
  • P32 3 4
  • Inhibitor Of Growth Family, Member 1-Like 2
  • Inhibitor Of Growth Protein 2 3

External Ids for ING2 Gene

Previous Symbols for ING2 Gene

  • ING1L

Summaries for ING2 Gene

Entrez Gene Summary for ING2 Gene

  • This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for ING2 Gene

ING2 (Inhibitor Of Growth Family, Member 2) is a Protein Coding gene. Among its related pathways are Senescence and Autophagy. GO annotations related to this gene include chromatin binding and phosphatidylinositol binding. An important paralog of this gene is ING4.

UniProtKB/Swiss-Prot for ING2 Gene

  • Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).

Gene Wiki entry for ING2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ING2 Gene

Genomics for ING2 Gene

Genomic Location for ING2 Gene

Start:
183,504,994 bp from pter
End:
183,512,269 bp from pter
Size:
7,276 bases
Orientation:
Plus strand

Genomic View for ING2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ING2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ING2 Gene

Regulatory Elements for ING2 Gene

Proteins for ING2 Gene

  • Protein details for ING2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H160-ING2_HUMAN
    Recommended name:
    Inhibitor of growth protein 2
    Protein Accession:
    Q9H160
    Secondary Accessions:
    • B6ZDS1
    • O95698

    Protein attributes for ING2 Gene

    Size:
    280 amino acids
    Molecular mass:
    32808 Da
    Quaternary structure:
    • Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of a mSin3A-like complex at least consisting of SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2.

    Alternative splice isoforms for ING2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ING2 Gene

Proteomics data for ING2 Gene at MOPED

Post-translational modifications for ING2 Gene

  • Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ING2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ING2 Gene

Domains for ING2 Gene

Gene Families for ING2 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

UniProtKB/Swiss-Prot:

ING2_HUMAN
Domain:
  • The PHD-type zinc finger mediates the binding to H3K4me3.:
    • Q9H160
  • The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P).:
    • Q9H160
Family:
  • Belongs to the ING family.:
    • Q9H160
Similarity:
  • Contains 1 PHD-type zinc finger.:
    • Q9H160
genes like me logo Genes that share domains with ING2: view

Function for ING2 Gene

Molecular function for ING2 Gene

UniProtKB/Swiss-Prot Function: Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
UniProtKB/Swiss-Prot Induction: Induced by the DNA-damaging agents etoposide and neocarzinostatin.

Gene Ontology (GO) - Molecular Function for ING2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 15243141
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 18334480
GO:0008270 zinc ion binding IEA --
GO:0032403 protein complex binding IDA 18334480
genes like me logo Genes that share ontologies with ING2: view
genes like me logo Genes that share phenotypes with ING2: view

Animal Models for ING2 Gene

MGI Knock Outs for ING2:

miRNA for ING2 Gene

miRTarBase miRNAs that target ING2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ING2 Gene

Localization for ING2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ING2 Gene

Nucleus. Note=Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ING2 Gene COMPARTMENTS Subcellular localization image for ING2 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ING2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15243141
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0016580 Sin3 complex IDA 16387653
genes like me logo Genes that share ontologies with ING2: view

Pathways for ING2 Gene

SuperPathways for ING2 Gene

Superpath Contained pathways
1 Senescence and Autophagy
genes like me logo Genes that share pathways with ING2: view

Pathways by source for ING2 Gene

1 BioSystems pathway for ING2 Gene

Gene Ontology (GO) - Biological Process for ING2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 15243141
GO:0007141 male meiosis I ISS 21124965
GO:0007165 signal transduction TAS 10072587
GO:0007283 spermatogenesis ISS 21124965
genes like me logo Genes that share ontologies with ING2: view

Transcripts for ING2 Gene

Unigene Clusters for ING2 Gene

Inhibitor of growth family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ING2 Gene

No ASD Table

Relevant External Links for ING2 Gene

GeneLoc Exon Structure for
ING2
ECgene alternative splicing isoforms for
ING2

Expression for ING2 Gene

mRNA expression in normal human tissues for ING2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ING2 Gene

SOURCE GeneReport for Unigene cluster for ING2 Gene Hs.107153

mRNA Expression by UniProt/SwissProt for ING2 Gene

Q9H160-ING2_HUMAN
Tissue specificity: Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
genes like me logo Genes that share expressions with ING2: view

Orthologs for ING2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ING2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ING2 36
  • 99.88 (n)
  • 100 (a)
ING2 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ING2 36
  • 91.55 (n)
  • 98.21 (a)
ING2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ING2 36
  • 94.88 (n)
  • 97.5 (a)
ING2 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ing2 36
  • 90.6 (n)
  • 96.79 (a)
Ing2 16
Ing2 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ING2 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ing2 36
  • 91.4 (n)
  • 96.77 (a)
chicken
(Gallus gallus)
Aves ING2 36
  • 75.55 (n)
  • 81.97 (a)
ING2 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ING2 37
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398266 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ing2 36
  • 71.68 (n)
  • 70.61 (a)
Str.6306 36
zebrafish
(Danio rerio)
Actinopterygii ing2 36
  • 67.7 (n)
  • 76.45 (a)
ing2 37
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7379 37
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO23 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10422 37
  • 30 (a)
OneToMany
Species with no ortholog for ING2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ING2 Gene

ENSEMBL:
Gene Tree for ING2 (if available)
TreeFam:
Gene Tree for ING2 (if available)

Paralogs for ING2 Gene

Paralogs for ING2 Gene

Selected SIMAP similar genes for ING2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ING2: view

Variants for ING2 Gene

Sequence variations from dbSNP and Humsavar for ING2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3193658 -- 183,511,029(-) ATGCA(G/T)TTACC utr-variant-3-prime
rs3193659 -- 183,511,004(-) GAAAG(C/T)AAACG utr-variant-3-prime
rs3193661 -- 183,510,994(-) GAATT(A/C)TATAA utr-variant-3-prime
rs3193663 -- 183,510,980(-) ACAAA(G/T)AACCC utr-variant-3-prime
rs3193666 -- 183,510,954(-) GCCTT(C/T)ACTAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ING2 Gene

Variant ID Type Subtype PubMed ID
nsv830165 CNV Loss 17160897
nsv822873 CNV Gain 20364138

Relevant External Links for ING2 Gene

HapMap Linkage Disequilibrium report
ING2

Disorders for ING2 Gene

(1) Novoseek inferred disease relationships for ING2 Gene

Disease -log(P) Hits PubMed IDs
tumors 15.7 4

Relevant External Links for ING2

Genetic Association Database (GAD)
ING2
genes like me logo Genes that share disorders with ING2: view

No data available for UniProtKB/Swiss-Prot for ING2 Gene

Publications for ING2 Gene

  1. Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor. (PMID: 10072587) Shimada Y. … Horie M. (Cytogenet. Cell Genet. 1998) 2 3 4 23
  2. DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. (PMID: 11481424) Nagashima M. … Harris C.C. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23
  3. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. (PMID: 12859901) Gozani O. … Yuan J. (Cell 2003) 3 4 23
  4. ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. (PMID: 16024799) Pedeux R. … Harris C.C. (Mol. Cell. Biol. 2005) 3 23
  5. Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). (PMID: 11784859) Kuzmichev A. … Reinberg D. (Mol. Cell. Biol. 2002) 3 4

Products for ING2 Gene

Sources for ING2 Gene

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