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ING2 Gene

protein-coding   GIFtS: 57
GCID: GC04P184426

Inhibitor Of Growth Family, Member 2

(Previous names: inhibitor of growth family, member 1-like)
(Previous symbol: ING1L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inhibitor Of Growth Family, Member 21 2     p322 3
ING1L1 2 3 5     p33ING22 3
Inhibitor Of Growth 1-Like Protein2 3     Inhibitor Of Growth Family, Member 1-Like1
ING1Lp2 3     Inhibitor Of Growth Protein 22

External Ids:    HGNC: 60631   Entrez Gene: 36222   Ensembl: ENSG000001685567   OMIM: 6042155   UniProtKB: Q9H1603   

Export aliases for ING2 gene to outside databases

Previous GC identifers: GC00U990666 GC0XM068188 GC0XM068944 GC0XM069578 GC0XM070494 GC04P184802 GC04P184663 GC04P180185


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ING2 Gene:
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and
modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in
DNA repair and apoptosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for ING2 Gene:
ING2 (inhibitor of growth family, member 2) is a protein-coding gene. Diseases associated with ING2 include soft tissue sarcoma, and basal cell carcinoma. GO annotations related to this gene include chromatin binding and phosphatidylinositol binding. An important paralog of this gene is ING4.

UniProtKB/Swiss-Prot: ING2_HUMAN, Q9H160
Function: Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by
enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in
deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides
(PtdInsPs)

Gene Wiki entry for ING2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ING2 gene promoter:
         TBP   STAT5B   Spz1   Sp1   p300   FAC1   Nkx6-1   HSF2   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidING2 promoter sequence
   Search Chromatin IP Primers for ING2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ING2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35.1

ING2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ING2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P184426:  view genomic region     (about GC identifiers)

Start:
184,426,147 bp from pter      End:
184,432,249 bp from pter
Size:
6,103 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ING2_HUMAN, Q9H160 (See protein sequence)
Recommended Name: Inhibitor of growth protein 2  
Size: 280 amino acids; 32808 Da
Subunit: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of a mSin3A-like complex at least
consisting of SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2
Secondary accessions: B6ZDS1 O95698
Alternative splicing: 2 isoforms:  Q9H160-1   Q9H160-2   (Low expression except in testis, where it reaches half of ING2a levels)

Explore the universe of human proteins at neXtProt for ING2: NX_Q9H160

Explore proteomics data for ING2 at MOPED

Post-translational modifications: 

  • Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is
    the case for TMEM711
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ING2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001555.1  
    ENSEMBL proteins: 
     ENSP00000307183   ENSP00000410291   ENSP00000412586  

    ING2 Human Recombinant Protein Products:

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    Novus Biologicals ING2 Lysates
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    Cloud-Clone Corp. Proteins for ING2

    ING2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for ING2

    ING2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ING2
    Cloud-Clone Corp. CLIAs for ING2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 8):
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR028651 ING_fam
     IPR028639 ING2
     IPR024610 ING_N

    Graphical View of Domain Structure for InterPro Entry Q9H160

    ProtoNet protein and cluster: Q9H160

    1 Blocks protein domain: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: ING2_HUMAN, Q9H160
    Domain: The PHD-type zinc finger mediates the binding to H3K4me3
    Domain: The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including
    phosphatidylinositol 5-phosphate (PtdIns(5)P)
    Similarity: Belongs to the ING family
    Similarity: Contains 1 PHD-type zinc finger


    ING2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ING2_HUMAN, Q9H160
    Function: Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by
    enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in
    deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides
    (PtdInsPs)
    Induction: Induced by the DNA-damaging agents etoposide and neocarzinostatin

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15243141
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI18334480
    GO:0008270zinc ion binding IEA--
    GO:0032403protein complex binding IDA18334480
         
    ING2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ING2:
     Decreased nuclei size in G2M 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ing2):
     cellular  endocrine/exocrine gland  hematopoietic system  immune system  mortality/aging 
     reproductive system  tumorigenesis 

    ING2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ing2tm1.1Ccha for ING2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ING2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ING2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ING2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ING2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ING2:
    hsa-mir-26b-5p (MIRT029061)

    Block miRNA regulation of human, mouse, rat ING2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ING2 (see all 14):
    hsa-miR-448 hsa-miR-137 hsa-miR-92a hsa-miR-586 hsa-miR-367 hsa-miR-25 hsa-miR-944 hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidING2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ING2
    Predesigned siRNA for gene silencing in human, mouse, rat ING2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ING2

    Clone
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    OriGene clones in human, mouse for ING2 (see all 7)
    OriGene ORF clones in mouse, rat for ING2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ING2 (NM_001564)
    Sino Biological Human cDNA Clone for ING2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ING2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ING2_HUMAN, Q9H160: Nucleus. Note=Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced
    PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular2
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15243141
    GO:0016580Sin3 complex IDA16387653
    GO:0016602CCAAT-binding factor complex IDA15243141

    ING2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ING2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Senescence and Autophagy
    Senescence and Autophagy


    1 BioSystems Pathway for ING2
        Senescence and Autophagy



        Pathway & Disease-focused RT2 Profiler PCR Array including ING2: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ING2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ING2 (Q9H1601, 2, 3 ENSP000003071834) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA15243141
    GO:0007141male meiosis I ISS--
    GO:0007165signal transduction TAS10072587
    GO:0007283spermatogenesis ISS--

    ING2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ING2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ING2 gene: 
    NM_001564.2  

    Unigene Cluster for ING2:

    Inhibitor of growth family, member 2
    Hs.107153  [show with all ESTs]
    Unigene Representative Sequence: NM_001564
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302327(uc003ivs.1 uc011ckk.1) ENST00000412117 ENST00000434682

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ING2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ING2 (see all 14):
    hsa-miR-448 hsa-miR-137 hsa-miR-92a hsa-miR-586 hsa-miR-367 hsa-miR-25 hsa-miR-944 hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidING2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ING2
    Predesigned siRNA for gene silencing in human, mouse, rat ING2
    Clone
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    OriGene ORF clones in mouse, rat for ING2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ING2 (NM_001564)
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    Primer
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    OriGene qPCR primer pairs and template standards for ING2
    OriGene qSTAR qPCR primer pairs in human, mouse for ING2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ING2
      QuantiTect SYBR Green Assays in human, mouse, rat ING2
      QuantiFast Probe-based Assays in human, mouse, rat ING2

    Additional mRNA sequence: 

    AB012853.1 AB196793.1 AF053537.1 AJ006851.1 AK294310.1 AK314000.1 BC030128.2 

    2 DOTS entries:

    DT.214433  DT.92426807 

    Selected AceView cDNA sequences (see all 51):

    AW674790 AA312454 AF053537 N59134 BM929984 BC030128 BF740046 BG741809 
    BM982877 BM719460 BE772998 CD675497 BF063702 NM_001564 BG211544 AB012853 
    BI460319 N75172 AJ006851 AI160411 BI548536 BE773086 AI126389 BU196949 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ING2 expression in normal human tissues (normalized intensities)      ING2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTCACTT
    ING2 Expression
    About this image


    ING2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    ING2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ING2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.107153

    UniProtKB/Swiss-Prot: ING2_HUMAN, Q9H160
    Tissue specificity: Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including ING2: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat ING2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ING2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ing21 , 5 inhibitor of growth family, member 21, 5 90.6(n)1
    96.79(a)1
      8 (26.87 cM)5
    692601  NM_023503.31  NP_075992.21 
     476671785 
    chicken
    (Gallus gallus)
    Aves ING21 inhibitor of growth family, member 2 75.55(n)
    81.97(a)
      422553  XM_004941133.1  XP_004941190.1 
    lizard
    (Anolis carolinensis)
    Reptilia ING26
    inhibitor of growth family, member 2
    69(a)
    1 ↔ 1
    5(113810896-113817387)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3982662 p32INGL 74.92(n)    AY014017.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ing21 inhibitor of growth family, member 2 67.7(n)
    76.45(a)
      436721  NM_001002448.1  NP_001002448.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73796
    --
    25(a)
    1 → many
    3R(13622098-13624026)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO236
    Probable component of the Rpd3 histone deacetylase...
    21(a)
    1 → many
    XIV(441366-442358) YNL097C


    ENSEMBL Gene Tree for ING2 (if available)
    TreeFam Gene Tree for ING2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ING2 gene
    ING42  ING52  ING32  ING12  
    4 SIMAP similar genes for ING2 using alignment to 3 protein entries:     ING2_HUMAN (see all proteins):
    ING3    ING1    ING5    ING4

    ING2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ING2 (see all 111)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872235491,2
    --184427688(+) TAAAAA/GGGGAA 1 -- int10--------
    rs1916338461,2
    --184427751(+) GGAAAC/GAGCCA 1 -- int10--------
    rs1405225961,2
    C--184427780(+) TTTCCG/TGGACC 1 -- int10--------
    rs726893821,2
    C,F--184427839(+) TCTAAG/AGAATC 1 -- int11Minor allele frequency- A:0.19EA 120
    rs726893831,2
    C,F--184427875(+) GATGTT/CTTTTA 1 -- int12Minor allele frequency- C:0.10NA EA 240
    rs738705801,2
    C,F--184428003(+) TATTTC/ATTTTA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1456740791,2
    --184428032(+) AGTAAC/TTCGTC 1 -- int10--------
    rs767656321,2
    C,F--184428065(+) TTGGCT/CCCAGA 1 -- int11Minor allele frequency- C:0.08EA 120
    rs1894272991,2
    --184428072(+) CAGAGC/TCTGCT 1 -- int10--------
    rs1931511051,2
    --184428085(+) TGTAGA/GTGCAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for ING2 (184426147 - 184432249 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ING2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830165CNV Loss17160897
    nsv822873CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ING2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604215    OMIM disorders: --

    7 diseases for ING2:    About MalaCards
    soft tissue sarcoma    basal cell carcinoma    sarcoma    lung cancer
    hepatocellular carcinoma    melanoma    squamous cell carcinoma


    ING2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ING2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 15.7 5 10072587 (2), 12859901 (1), 16024799 (1)

    Genetic Association Database (GAD): ING2

    Export disorders for ING2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ING2 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with ING2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor. (PubMed id 10072587)1, 2, 3, 9 Shimada Y.... Horie M. (Cytogenet. Cell Genet. 1998)
    2. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. (PubMed id 12859901)1, 2, 9 Gozani O.... Yuan J. (Cell 2003)
    3. DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. (PubMed id 11481424)1, 2, 9 Nagashima M.... Harris C.C. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    4. Sumoylation of ING2 regulates the transcription mediated by Sin3A. (PubMed id 20676127)1, 2 Ythier D....Pedeux R. (Oncogene 2010)
    5. A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis. (PubMed id 18951897)1, 2 Unoki M....Harris C.C. (FEBS Lett. 2008)
    6. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. (PubMed id 16728974)1, 2 Shi X.... Gozani O. (Nature 2006)
    7. The polybasic region that follows the plant homeodomain zinc finger 1 of Pf1 is necessary and sufficient for specific phosphoinositide binding. (PubMed id 16893883)1, 2 Kaadige M.R. and Ayer D.E. (J. Biol. Chem. 2006)
    8. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2 Doyon Y.... Cote J. (Mol. Cell 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). (PubMed id 11784859)1, 2 Kuzmichev A.... Reinberg D. (Mol. Cell. Biol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3622 HGNC: 6063 AceView: ING1L Ensembl:ENSG00000168556 euGenes: HUgn3622
    ECgene: ING2 H-InvDB: ING2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ING2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ING2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ING2 gene:
    Search GeneIP for patents involving ING2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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