Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ING1 Gene

protein-coding   GIFtS: 64
GCID: GC13P111365

Inhibitor Of Growth Family, Member 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Inhibitor Of Growth Family, Member 11 2     p24ING1c2
Growth Inhibitor ING11 2     p332
Growth Inhibitory Protein ING11 2     p33ING12
Tumor Suppressor ING11 2     p33ING1b2
Inhibitor Of Growth 11     p472
Inhibitor Of Growth Protein 12     p47ING1a2

External Ids:    HGNC: 60621   Entrez Gene: 36212   Ensembl: ENSG000001534877   OMIM: 6015665   UniProtKB: Q9UK533   

Export aliases for ING1 gene to outside databases

Previous GC identifers: GC13P109725 GC13P105752 GC13P110202 GC13P109063 GC13P110163 GC13P091963


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ING1 Gene:
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein
is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the
p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ING1 Gene:
ING1 (inhibitor of growth family, member 1) is a protein-coding gene. Diseases associated with ING1 include squamous cell carcinoma, head and neck, somatic, and squamous cell carcinoma of the head and neck. GO annotations related to this gene include methylated histone residue binding. An important paralog of this gene is ING2.

UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53
Function: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent
transcriptional activation. Implicated as a tumor suppressor gene

Gene Wiki entry for ING1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_009952.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the ING1 gene promoter:
         COMP1   Nkx2-5   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ING1 promoter sequence
   Search Chromatin IP Primers for ING1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ING1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

ING1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ING1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P111365:  view genomic region     (about GC identifiers)

Start:
111,365,083 bp from pter      End:
111,373,421 bp from pter
Size:
8,339 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53 (See protein sequence)
Recommended Name: Inhibitor of growth protein 1  
Size: 422 amino acids; 46738 Da
Subunit: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Interacts with TP53
Sequence caution: Sequence=AAB60879.1; Type=Frameshift; Positions=149; Sequence=AAG02579.1; Type=Erroneous gene
model prediction;
1 PDB 3D structure from and Proteopedia for ING1:
2QIC (3D)    
Secondary accessions: O00532 O43658 Q53ZR3 Q5T9G8 Q5T9G9 Q5T9H0 Q5T9H1 Q9H007 Q9HD98 Q9HD99
Q9NS83 Q9P0U6 Q9UBC6 Q9UIJ1 Q9UIJ2 Q9UIJ3 Q9UIJ4 Q9UK52
Alternative splicing: 5 isoforms:  Q9UK53-1   Q9UK53-2   Q9UK53-3   Q9UK53-4   Q9UK53-5   

Explore the universe of human proteins at neXtProt for ING1: NX_Q9UK53

Explore proteomics data for ING1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ING1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001254657.1  NP_005528.4  NP_937860.1  NP_937861.1  NP_937862.1  

    ENSEMBL proteins: 
     ENSP00000345202   ENSP00000328436   ENSP00000364930   ENSP00000364929  

    ING1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ING1
    OriGene Protein Over-expression Lysate for ING1
    OriGene MassSpec for ING1
    OriGene Custom Protein Services for ING1
    GenScript Custom Purified and Recombinant Proteins Services for ING1
    Novus Biologicals ING1 Proteins
    Novus Biologicals ING1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ING1

    ING1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ING1
    R&D Systems Antibodies for ING1
    OriGene Antibodies for ING1
    OriGene Custom Antibody Services for ING1
    Novus Biologicals ING1 Antibodies
    Abcam antibodies for ING1
    Cloud-Clone Corp. Antibodies for ING1
    ThermoFisher Antibodies for ING1
    LSBio Antibodies in human, mouse, rat for ING1

    ING1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ING1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ING1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ING1
    Cloud-Clone Corp. CLIAs for ING1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 8):
     IPR001965 Znf_PHD
     IPR028643 ING1
     IPR013083 Znf_RING/FYVE/PHD
     IPR028651 ING_fam
     IPR024610 ING_N

    Graphical View of Domain Structure for InterPro Entry Q9UK53

    ProtoNet protein and cluster: Q9UK53

    1 Blocks protein domain: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53
    Domain: The PHD-type zinc finger mediates the binding to H3K4me3
    Domain: The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including
    phosphatidylinositol 5-phosphate (PtdIns(5)P) (By similarity)
    Similarity: Belongs to the ING family
    Similarity: Contains 1 PHD-type zinc finger


    ING1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ING1_HUMAN, Q9UK53
    Function: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent
    transcriptional activation. Implicated as a tumor suppressor gene

         Genatlas biochemistry entry for ING1:
    inhibitor of cell growth 1,located in the nucleus,underexpressed in breast cancer and neuroblastoma cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18388957
    GO:0008270zinc ion binding IEA--
    GO:0035064methylated histone residue binding IDA16728974
         
    ING1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ING1:
     Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ing1):
     behavior/neurological  cellular  growth/size/body  hematopoietic system  immune system 
     mortality/aging  tumorigenesis 

    ING1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ing1tm1Avg for ING1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ING1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ING1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ING1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ING1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ING1:
    hsa-mir-662 (MIRT006996), hsa-mir-103a-3p (MIRT026987)

    Block miRNA regulation of human, mouse, rat ING1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ING1 (see all 23):
    hsa-miR-579 hsa-miR-374a hsa-miR-301a hsa-miR-578 hsa-miR-519a hsa-miR-570 hsa-miR-130b hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidING1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ING1
    Predesigned siRNA for gene silencing in human, mouse, rat ING1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ING1

    Clone
    Products:
         
    OriGene clones in human, mouse for ING1 (see all 22)
    OriGene ORF clones in mouse, rat for ING1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ING1 (NM_000062)
    Sino Biological Human cDNA Clone for ING1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ING1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ING1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ING1_HUMAN, Q9UK53: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10866301

    ING1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ING1 About    
    See pathways by source

    SuperPathContained pathways About
    1Senescence and Autophagy
    Senescence and Autophagy


    1 BioSystems Pathway for ING1
        Senescence and Autophagy



        Pathway & Disease-focused RT2 Profiler PCR Arrays including ING1: 
              Cancer PathwayFinder in human mouse rat
              Cellular Senescence in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ING1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ING1 (Q9UK531, 2, 3 ENSP000003649294) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST4H4P628053, ENSP000003507674I2D: score=1 STRING: ENSP00000350767
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006606protein import into nucleus IEA--
    GO:0007049cell cycle IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0010941regulation of cell death IEA--
    GO:0016568chromatin modification IEA--

    ING1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ING1

    5 Novoseek inferred chemical compound relationships for ING1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    etoposide 14.9 2 15191662 (1), 11481424 (1)
    zinc 0 1 12632089 (1)
    estrogen 0 15 14630091 (6), 14718790 (6)
    cisplatin 0 6 17763999 (4)
    paclitaxel 0 6 15662138 (5)



    ING1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ING1 gene (5 alternative transcripts): 
    NM_001267728.1  NM_005537.5  NM_198217.2  NM_198218.2  NM_198219.2  

    Unigene Cluster for ING1:

    Inhibitor of growth family, member 1
    Hs.46700  [show with all ESTs]
    Unigene Representative Sequence: AF181850
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338450 ENST00000333219(uc001vrf.3 uc001vrg.3 uc001vrh.3)
    ENST00000375775 ENST00000375774(uc001vri.3) ENST00000464141
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ING1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ING1 (see all 23):
    hsa-miR-579 hsa-miR-374a hsa-miR-301a hsa-miR-578 hsa-miR-519a hsa-miR-570 hsa-miR-130b hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidING1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ING1
    Predesigned siRNA for gene silencing in human, mouse, rat ING1
    Clone
    Products:
         
    OriGene clones in human, mouse for ING1 (see all 22)
    OriGene ORF clones in mouse, rat for ING1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ING1 (NM_000062)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ING1
    OriGene qSTAR qPCR primer pairs in human, mouse for ING1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ING1
      QuantiTect SYBR Green Assays in human, mouse, rat ING1
      QuantiFast Probe-based Assays in human, mouse, rat ING1

    Additional mRNA sequence: 

    AB024401.1 AB024402.1 AB031269.1 AB037594.2 AF001954.1 AF044076.1 AF078835.1 AF149721.1 
    AF149722.1 AF149723.1 AF181849.1 AF181850.1 AJ310392.1 AK302353.1 BC018348.1 BC093942.1 
    BC093944.1 

    10 DOTS entries:

    DT.445761  DT.306030  DT.40271316  DT.95261599  DT.97859918  DT.91696048  DT.100745733  DT.100827727 
    DT.102843367  DT.75110001 

    Selected AceView cDNA sequences (see all 461):

    NM_198217 AK093771 AW469151 AA628769 BM699852 AA010947 AA916415 BQ683151 
    AA828160 AI368102 BM979895 BM023119 AA984395 CB216294 BF338696 BM020864 
    BQ955656 AA336510 AA256598 AL541840 AI350377 CF529479 AA598872 AA975682 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ING1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTGCTAT
    ING1 Expression
    About this image

    ING1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ING1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.46700

    UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53
    Tissue specificity: Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast
    cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed
    in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis
    and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma
    cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ING1: 
              Cancer PathwayFinder in human mouse rat
              Cellular Senescence in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ING1
    OriGene qSTAR qPCR primer pairs in human, mouse for ING1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ING1
    QuantiTect SYBR Green Assays in human, mouse, rat ING1
    QuantiFast Probe-based Assays in human, mouse, rat ING1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ING1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ing11 , 5 inhibitor of growth family, member 11, 5 85.78(n)1
    90.32(a)1
      8 (5.73 cM)5
    263561  NM_011919.41  NP_036049.21 
     115560665 
    chicken
    (Gallus gallus)
    Aves ING11 inhibitor of growth family, member 1 75.32(n)
    87.23(a)
      418759  XM_416956.4  XP_416956.4 
    lizard
    (Anolis carolinensis)
    Reptilia ING16
    inhibitor of growth family, member 1
    76(a)
    1 ↔ 1
    3(104502076-104507934)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480487972   -- 77.23(n)    48048797 
    zebrafish
    (Danio rerio)
    Actinopterygii 570790992   -- 74.67(n)    57079099 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73791 CG7379 59.9(n)
    47.4(a)
      42140  NM_142399.3  NP_650656.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO23(YNL097C)4 Probable component of the Rpd3 histone deacetylase more   --   14(442358-441366) 855626  NP_014302.1 
    rice
    (Oryza sativa)
    Liliopsida AB110188.12   -- 72.35(n)    AB110188.1 


    ENSEMBL Gene Tree for ING1 (if available)
    TreeFam Gene Tree for ING1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ING1 gene
    ING22  ING42  ING52  ING32  
    2 SIMAP similar genes for ING1 using alignment to 1 protein entry:     ING1_HUMAN:
    ING2    ING4

    ING1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ING1
    PGOHUM00000258731 PGOHUM00000241382


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ING1 (see all 281)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0174224
    Squamous cell carcinoma of the head and neck (HNSCC)4--see VAR_0174222 N S mis40--------
    VAR_0174204
    Squamous cell carcinoma of the head and neck (HNSCC)4--see VAR_0174202 A D mis40--------
    VAR_0174214
    Squamous cell carcinoma of the head and neck (HNSCC)4--see VAR_0174212 C S mis40--------
    rs47732411,2
    C,F,A,H--91961442(+) GCTTGG/ATCTTC 1 -- us2k123Minor allele frequency- A:0.35NS EA NA WA CSA 2344
    rs1177733281,2
    C,F--91961527(+) GTAAAG/ACTCCA 1 -- us2k11Minor allele frequency- A:0.04NA 120
    rs1170799921,2
    F--91961634(+) TTTGGT/CTTATG 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1840121721,2
    --91961655(+) GAGAGC/TACATA 1 -- us2k10--------
    rs583423011,2
    C--91961715(+) TTTTT-/T/TT  
            
    AAAAA
    1 -- us2k10--------
    rs23918661,2
    C--91961716(+) TTTTTT/AAAAAG 1 -- us2k1 trp31Minor allele frequency- A:0.50NA 2
    rs1919529871,2
    --91961920(+) ACTTTA/GTACTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ING1 (111365083 - 111373421 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ING1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901014CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ING1
    DNA2.0 Custom Variant and Variant Library Synthesis for ING1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601566   
    OMIM disorders: 275355  
    UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53
  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting
    the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for ING1 (see all 29):    
    About MalaCards
    squamous cell carcinoma, head and neck, somatic    squamous cell carcinoma of the head and neck    fibrosarcoma of bone    fibrosarcoma
    sporadic breast cancer    mantle cell lymphoma    osteosarcoma    oral squamous cell carcinoma
    basal cell carcinoma    oral cancer    hepatocellular carcinoma    squamous cell carcinoma
    colorectal cancer    laryngeal squamous cell carcinoma    gastric adenocarcinoma    laryngitis
    breast cancer    astrocytoma    neuroblastoma    melanoma


    ING1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ING1 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 54.8 123 11991811 (5), 10679922 (4), 12637159 (4), 17763999 (4) (see all 59)
    allelic loss 46.2 1 10866301 (1)
    melanoma 32.3 35 11966686 (6), 12429989 (6), 12012016 (4), 15201991 (3) (see all 7)
    cancer 29.7 21 10498868 (2), 12835293 (2), 12835295 (1), 12523595 (1) (see all 15)
    glioma 29.1 19 12882685 (5), 14676120 (5), 10554029 (3), 12653407 (1) (see all 6)
    neoplastic transformation 22.6 4 8944021 (1), 9330636 (1)
    carcinoma squamous cell 21.9 7 17805569 (2), 11287275 (2), 10866301 (1), 9330636 (1)
    hepatocellular carcinoma 20.2 8 12523595 (2), 14642087 (2), 18450387 (1), 19085961 (1)
    breast cancer 17 30 10626813 (5), 12835295 (4), 10754201 (4), 10498868 (4) (see all 8)
    brain tumors 12.7 12 14676120 (6), 12820433 (3)

    Genetic Association Database (GAD): ING1
    Human Genome Epidemiology (HuGE) Navigator: ING1 (2 documents)

    Export disorders for ING1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ING1 gene, integrated from 10 sources (see all 149):
    (articles sorted by number of sources associating them with ING1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation. (PubMed id 8944021)1, 2, 3, 9 Garkavtsev I.A.... Riabowol K. (Nat. Genet. 1996)
    2. Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. (PubMed id 18533182)1, 2, 9 Pena P.V.... Kutateladze T.G. (J. Mol. Biol. 2008)
    3. Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene. (PubMed id 10626813)1, 2, 9 Jaeger D.... Chen Y.-T. (Cancer Res. 1999)
    4. The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control. (PubMed id 9440695)1, 2, 9 Garkavtsev I.A.... Gudkov A.V. (Nature 1998)
    5. DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. (PubMed id 11481424)1, 2, 9 Nagashima M.... Harris C.C. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    6. Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1). (PubMed id 9186514)1, 3, 9 Garkavtsev I....Riabowol K. (Cytogenet. Cell Genet. 1997)
    7. Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. (PubMed id 10866301)1, 2, 9 Gunduz M.... Shimizu K. (Cancer Res. 2000)
    8. Genetic variation in healthy oldest-old. (PubMed id 19680556)1, 4, 9 Halaschek-Wiener J....Brooks-Wilson A.R. (PLoS ONE 2009)
    9. The predictive value of p53 and p33(ING1b) in patients with Dukes'C colorectal cancer. (PubMed id 17949449)1, 4 Ahmed I.A....Lunec J. (Colorectal Dis 2008)
    10. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. (PubMed id 16728974)1, 2 Shi X.... Gozani O. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3621 HGNC: 6062 AceView: ING1andFLJ10769 Ensembl:ENSG00000153487 euGenes: HUgn3621
    ECgene: ING1 H-InvDB: ING1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ING1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ING1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ING1 gene:
    Search GeneIP for patents involving ING1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ING1
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for ING1 (ING1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ING1   OriGene RNAi products in human, mouse, rat for ING1  
     OriGene qPCR primer pairs and template standards for ING1   OriGene Protein Over-expression Lysate for ING1  
     OriGene MassSpec something-or-other for ING1   OriGene clones in human, mouse for ING1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ING1   OriGene Purified Protein for ING1  
     OriGene ORF clones in mouse, rat for ING1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ING1   OriGene Custom Protein Services for ING1  

     
     
     Block miRNA regulation of human, mouse, rat ING1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ING1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ING1 Predesigned siRNA for gene silencing in human, mouse, rat ING1
     QuantiFast Probe-based Assays in human, mouse, rat ING1 QuantiTect SYBR Green Assays in human, mouse, rat ING1
     PCR Arrays including human, mouse, rat ING1 Search Chromatin IP Primers for ING1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ING1  GeneGlobe Interaction Network for ING1
     Regulatory tfbs in ING1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ING1 GenScript cDNA clones with any tag delivered in your preferred vector for ING1
     GenScript Custom Assay Services for ING1 GenScript Custom overexpressing Cell Line Services for ING1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ING1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ING1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ING1 antibodies
     ING1 proteins
     ING1 lysates
     Antibodies for ING1
     See all of Abcam's Antibodies, Kits and Proteins for ING1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ING1
     Antibodies for ING1
     ELISAs for ING1
     CLIAs for ING1



     Browse ESI BIO Cell Lines and PureStem Progenitors for ING1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING1
     SwitchGear 3'UTR luciferase reporter plasmids for ING1
     SwitchGear Promoter luciferase reporter plasmids for ING1
     ThermoFisher Antibodies for ING1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ING1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ING1
     LSBio Antibodies in human, mouse, rat for ING1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ING1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4