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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ING1 Gene

protein-coding   GIFtS: 64
GCID: GC13P111365

Inhibitor Of Growth Family, Member 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Inhibitor Of Growth Family, Member 11 2     p24ING1c2
Growth Inhibitor ING11 2     p332
Growth Inhibitory Protein ING11 2     p33ING12
Tumor Suppressor ING11 2     p33ING1b2
Inhibitor Of Growth 11     p472
Inhibitor Of Growth Protein 12     p47ING1a2

External Ids:    HGNC: 60621   Entrez Gene: 36212   Ensembl: ENSG000001534877   OMIM: 6015665   UniProtKB: Q9UK533   

Export aliases for ING1 gene to outside databases

Previous GC identifers: GC13P109725 GC13P105752 GC13P110202 GC13P109063 GC13P110163 GC13P091963


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ING1 Gene:
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein
is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the
p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ING1 Gene: 
ING1 (inhibitor of growth family, member 1) is a protein-coding gene. Diseases associated with ING1 include fibrosarcoma of bone, and fibrosarcoma. GO annotations related to this gene include methylated histone residue binding and zinc ion binding. An important paralog of this gene is ING2.

UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53
Function: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent
transcriptional activation. Implicated as a tumor suppressor gene

Gene Wiki entry for ING1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_009952.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ING1 gene promoter:
         COMP1   Nkx2-5   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ING1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ING1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ING1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

ING1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ING1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P111365:  view genomic region     (about GC identifiers)

Start:
111,365,083 bp from pter      End:
111,373,421 bp from pter
Size:
8,339 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53 (See protein sequence)
Recommended Name: Inhibitor of growth protein 1  
Size: 422 amino acids; 46738 Da
Subunit: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Interacts with TP53
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAB60879.1; Type=Frameshift; Positions=149; Sequence=AAG02579.1; Type=Erroneous gene
model prediction;
1 PDB 3D structure from and Proteopedia for ING1:
2QIC (3D)    
Secondary accessions: O00532 O43658 Q53ZR3 Q5T9G8 Q5T9G9 Q5T9H0 Q5T9H1 Q9H007 Q9HD98 Q9HD99
Q9NS83 Q9P0U6 Q9UBC6 Q9UIJ1 Q9UIJ2 Q9UIJ3 Q9UIJ4 Q9UK52
Alternative splicing: 5 isoforms:  Q9UK53-1   Q9UK53-2   Q9UK53-3   Q9UK53-4   Q9UK53-5   

Explore the universe of human proteins at neXtProt for ING1: NX_Q9UK53

Explore proteomics data for ING1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UK53

  • ING1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ING1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001254657.1  NP_005528.3  NP_937860.1  NP_937861.1  NP_937862.1  

    ENSEMBL proteins: 
     ENSP00000345202   ENSP00000328436   ENSP00000364930   ENSP00000364929  

    Human Recombinant Protein Products for ING1: 
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    Novus Biologicals ING1 Proteins
    Novus Biologicals ING1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ING1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10866301

    ING1 for ontologies           About GeneDecksing



    ING1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for ING1 

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ING1 
    Cloud-Clone Corp. CLIAs for ING1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PHF: Zinc fingers, PHD-type

    5/6 InterPro protein domains (see all 6):
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR024610 ING_N
     IPR019786 Zinc_finger_PHD-type_CS
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q9UK53

    ProtoNet protein and cluster: Q9UK53

    1 Blocks protein domain: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53
    Domain: The PHD-type zinc finger mediates the binding to H3K4me3
    Domain: The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including
    phosphatidylinositol 5-phosphate (PtdIns(5)P) (By similarity)
    Similarity: Belongs to the ING family
    Similarity: Contains 1 PHD-type zinc finger


    ING1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ING1_HUMAN, Q9UK53
    Function: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent
    transcriptional activation. Implicated as a tumor suppressor gene

         Genatlas biochemistry entry for ING1:
    inhibitor of cell growth 1,located in the nucleus,underexpressed in breast cancer and neuroblastoma cells

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18388957
    GO:0008270zinc ion binding IEA--
    GO:0035064methylated histone residue binding IDA16728974
         
    ING1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ING1:
     Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ing1):
     behavior/neurological  cellular  growth/size  hematopoietic system  immune system 
     mortality/aging  tumorigenesis 

    ING1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ing1tm1Avg for ING1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ING1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ING1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ING1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ING1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ING1
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ING1 (see all 23):
    hsa-miR-579 hsa-miR-374a hsa-miR-301a hsa-miR-578 hsa-miR-519a hsa-miR-570 hsa-miR-130b hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidING1 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for ING1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING1
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                         Customized lentivirus expression plasmids for stable overexpression of ING1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ING1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Senescence and Autophagy
    Senescence and Autophagy


    1 BioSystems Pathway for ING1
        Senescence and Autophagy



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ING1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for ING1 (Q9UK532, 3 ENSP000003649294) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST4H4P628053, ENSP000003507674I2D: score=1 STRING: ENSP00000350767
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006606protein import into nucleus IEA--
    GO:0007049cell cycle IEA--
    GO:0008285negative regulation of cell proliferation TAS8944021
    GO:0010941regulation of cell death IEA--
    GO:0030308negative regulation of cell growth NAS8944021

    ING1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ING1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ING1

    5 Novoseek inferred chemical compound relationships for ING1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    etoposide 14.9 2 15191662 (1), 11481424 (1)
    zinc 0 1 12632089 (1)
    estrogen 0 15 14630091 (6), 14718790 (6)
    cisplatin 0 6 17763999 (4)
    paclitaxel 0 6 15662138 (5)

    Search CenterWatch for drugs/clinical trials and news about ING1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ING1 gene (5 alternative transcripts): 
    NM_001267728.1  NM_005537.4  NM_198217.2  NM_198218.2  NM_198219.2  

    Unigene Cluster for ING1:

    Inhibitor of growth family, member 1
    Hs.46700  [show with all ESTs]
    Unigene Representative Sequence: AF181850
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338450 ENST00000333219(uc001vrf.3 uc001vrg.3 uc001vrh.3)
    ENST00000375775 ENST00000375774(uc001vri.3) ENST00000464141
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ING1
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ING1 (see all 23):
    hsa-miR-579 hsa-miR-374a hsa-miR-301a hsa-miR-578 hsa-miR-519a hsa-miR-570 hsa-miR-130b hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidING1 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    OriGene clones in human, mouse for ING1 (see all 23)
    OriGene ORF clones in mouse, rat for ING1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ING1 (NM_000062)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING1
    Sirion Biotech Customized lentivirus for stable overexpression of ING1 
                         Customized lentivirus expression plasmids for stable overexpression of ING1 
    Primer
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    OriGene qPCR primer pairs and template standards for ING1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ING1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ING1

    Additional mRNA sequence: 

    AB024401.1 AB024402.1 AB031269.1 AB037594.2 AF001954.1 AF044076.1 AF078835.1 AF149721.1 
    AF149722.1 AF149723.1 AF181849.1 AF181850.1 AJ310392.1 AK302353.1 BC018348.1 BC093942.1 
    BC093944.1 

    10 DOTS entries:

    DT.445761  DT.306030  DT.40271316  DT.95261599  DT.97859918  DT.91696048  DT.100745733  DT.100827727 
    DT.102843367  DT.75110001 

    24/461 AceView cDNA sequences (see all 461):

    BM457587 CB216294 AI272911 BQ883364 AJ310392 BM671482 BF338696 AW469145 
    AB037594 BM477126 BQ955656 NM_198219 AW439216 AA939010 BM020864 AI056700 
    BM977421 AA450055 BM830518 AA336370 AI350377 AU131402 AI540596 AI383830 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ING1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTGCTAT
    ING1 Expression
    About this image


    See ING1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ING1

    SOURCE GeneReport for Unigene cluster: Hs.46700

    UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53
    Tissue specificity: Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast
    cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed
    in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis
    and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma
    cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including ING1: 
              Cancer PathwayFinder in human mouse rat
              Cellular Senescence in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ING1 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ing11 , 5 inhibitor of growth family, member 11, 5 85.78(n)1
    90.32(a)1
      8 (5.73 cM)5
    263561  NM_011919.41  NP_036049.21 
     115560665 
    chicken
    (Gallus gallus)
    Aves ING11 inhibitor of growth family, member 1 75.36(n)
    87.18(a)
      418759  XM_416956.3  XP_416956.3 
    lizard
    (Anolis carolinensis)
    Reptilia ING16
    Uncharacterized protein
    74(a)
    1 ↔ 1
    3(104502076-104507934)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480487972   -- 77.23(n)    48048797 
    zebrafish
    (Danio rerio)
    Actinopterygii 570790992   -- 74.67(n)    57079099 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73791 CG7379 51.74(n)
    43.02(a)
      42140  NM_142399.2  NP_650656.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO23(YNL097C)4
    PHO231
    Probable component of the Rpd3 histone deacetylase more4
    Pho23p1
    45.37(n)1
    32.54(a)1
      14(442358-441366)4
    8556261, 4  NP_014302.31  NP_014302.14 
    rice
    (Oryza sativa)
    Liliopsida AB110188.12   -- 72.35(n)    AB110188.1 


    ENSEMBL Gene Tree for ING1 (if available)
    TreeFam Gene Tree for ING1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ING1 gene
    ING22  ING42  ING52  ING32  
    3 SIMAP similar genes for ING1 using alignment to 1 protein entry:     ING1_HUMAN:
    ING2    ING2b    ING4

    ING1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ING1
    PGOHUM00000258731 PGOHUM00000241382


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/281 SNPs in ING1 are shown (see all 281)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0174224
    Squamous cell carcinoma of the head and neck (HNSCC)4--see VAR_0174222 N S mis40--------
    VAR_0174204
    Squamous cell carcinoma of the head and neck (HNSCC)4--see VAR_0174202 A D mis40--------
    VAR_0174214
    Squamous cell carcinoma of the head and neck (HNSCC)4--see VAR_0174212 C S mis40--------
    rs47732411,2
    C,F,A,H--91961442(+) GCTTGG/ATCTTC 1 -- us2k123Minor allele frequency- A:0.35NS EA NA WA CSA 2344
    rs1177733281,2
    C,F--91961527(+) GTAAAG/ACTCCA 1 -- us2k11Minor allele frequency- A:0.04NA 120
    rs1170799921,2
    F--91961634(+) TTTGGT/CTTATG 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1840121721,2
    --91961655(+) GAGAGC/TACATA 1 -- us2k10--------
    rs583423011,2
    C--91961715(+) TTTTT-/T/TT  
            
    AAAAA
    1 -- us2k10--------
    rs23918661,2
    C--91961716(+) TTTTTT/AAAAAG 1 -- us2k1 trp31Minor allele frequency- A:0.50NA 2
    rs1919529871,2
    --91961920(+) ACTTTA/GTACTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ING1 (111365083 - 111373421 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ING1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv901014CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601566   
    OMIM disorders: 275355  
    UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53
  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting
    the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/24 diseases for ING1 (see all 24):    About MalaCards
    fibrosarcoma of bone    fibrosarcoma    sporadic breast cancer    mantle cell lymphoma
    osteosarcoma    oral squamous cell carcinoma    basal cell carcinoma    hepatocellular carcinoma
    oral cancer    gastric cancer    squamous cell carcinoma    colorectal cancer
    breast cancer    astrocytoma    melanoma    glioblastoma
    neuroblastoma    laryngitis    esophagitis    lung cancer


    ING1 for disorders           About GeneDecksing

    10/20 Novoseek inferred disease relationships for ING1 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 54.8 123 11991811 (5), 10679922 (4), 12637159 (4), 17763999 (4) (see all 59)
    allelic loss 46.2 1 10866301 (1)
    melanoma 32.3 35 11966686 (6), 12429989 (6), 12012016 (4), 15201991 (3) (see all 7)
    cancer 29.7 21 10498868 (2), 12835293 (2), 12835295 (1), 12523595 (1) (see all 15)
    glioma 29.1 19 12882685 (5), 14676120 (5), 10554029 (3), 12653407 (1) (see all 6)
    neoplastic transformation 22.6 4 8944021 (1), 9330636 (1)
    carcinoma squamous cell 21.9 7 17805569 (2), 11287275 (2), 10866301 (1), 9330636 (1)
    hepatocellular carcinoma 20.2 8 12523595 (2), 14642087 (2), 18450387 (1), 19085961 (1)
    breast cancer 17 30 10626813 (5), 12835295 (4), 10754201 (4), 10498868 (4) (see all 8)
    brain tumors 12.7 12 14676120 (6), 12820433 (3)

    Genetic Association Database (GAD): ING1
    Human Genome Epidemiology (HuGE) Navigator: ING1 (2 documents)

    Export disorders for ING1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ING1 gene, integrated from 9 sources (see all 146):
    (articles sorted by number of sources associating them with ING1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation. (PubMed id 8944021)1, 2, 3, 9 Garkavtsev I.A.... Riabowol K. (1996)
    2. Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. (PubMed id 18533182)1, 2, 9 Pena P.V....Kutateladze T.G. (2008)
    3. Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene. (PubMed id 10626813)1, 2, 9 Jaeger D.... Chen Y.-T. (1999)
    4. The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control. (PubMed id 9440695)1, 2, 9 Garkavtsev I.A.... Gudkov A.V. (1998)
    5. DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. (PubMed id 11481424)1, 2, 9 Nagashima M.... Harris C.C. (2001)
    6. Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1). (PubMed id 9186514)1, 3, 9 Garkavtsev I....Riabowol K. (1997)
    7. Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. (PubMed id 10866301)1, 2, 9 Gunduz M.... Shimizu K. (2000)
    8. Genetic variation in healthy oldest-old. (PubMed id 19680556)1, 4, 9 Halaschek-Wiener J....Brooks-Wilson A.R. (2009)
    9. The predictive value of p53 and p33(ING1b) in patients with Dukes'C colorectal cancer. (PubMed id 17949449)1, 4 Ahmed I.A....Lunec J. (2008)
    10. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. (PubMed id 16728974)1, 2 Shi X....Gozani O. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3621 HGNC: 6062 AceView: ING1andFLJ10769 Ensembl:ENSG00000153487 euGenes: HUgn3621
    ECgene: ING1 H-InvDB: ING1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ING1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ING1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ING1 gene:
    Search GeneIP for patents involving ING1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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