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Aliases & Descriptions for ING1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases OTTHUMP00000018703 2 OTTHUMP00000018704 2 OTTHUMP00000018705 2 OTTHUMP00000018706 2 p24ING1c 1 , 2 p33 1 , 2 p33ING1 1 , 2 p33ING1b 1 , 2 p47 1 , 2 p47ING1a 1 , 2
Descriptions growth inhibitor ING1 2 growth inhibitory protein ING1 2 inhibitor of growth family, member 1 2 tumor suppressor ING1 2
Search outside databases for aliases for ING1 genePrevious GC identifers: GC13P109725 GC13P105752 GC13P110202 GC13P109063
Summaries for ING1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ING1 : This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. Theencoded protein is a nuclear protein that physically interacts with the tumor suppressor proteinTP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of thisgene have been detected in various cancers. Multiple alternatively spliced transcript variantsencoding distinct isoforms have been reported. [provided by RefSeq] UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53 Function : Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulatingp53-dependent transcriptional activation. Implicated as a tumor suppressor gene
Gene Wiki entry for ING1
Genomic Location for ING1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ING1 gene Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34 ING1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure
GeneLoc location for GC13P110163:
(about GC identifiers )
Start:
110,163,084 bp from pter
End:
110,171,422 bp from pter
Size:
8,339 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000013.9 NT_009952.14 Proteins for ING1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53 (See
protein sequence )Recommended Name: Inhibitor of growth protein 1 Size : 422 amino acids; 46738 Da
Subunit : Interacts with TP53
Subcellular location : Nucleus (Probable)
Sequence caution : Sequence=AAB60879.1; Type=Frameshift; Positions=149; Sequence=AAG02579.1;Type=Erroneous gene model prediction;
PDB structures from and Proteopedia : 2QIC (3D)
 
Secondary accessions : O00532 O43658 Q5T9G9 Q9H007 Q9HD98 Q9HD99 Q9NS83 Q9P0U6 Q9UBC6 Q9UIJ1 Q9UIJ2Q9UIJ3 Q9UIJ4 Q9UK52 Alternative splicing : 5 isoforms : Q9UK53-1 Q9UK53-2 Q9UK53-3 Q9UK53-4 Q9UK53-5
REFSEQ proteins (4 alternative transcripts):
NP_005528.3 NP_937860.1 NP_937861.1 NP_937862.1 ENSEMBL proteins: ENSP00000364930 ENSP00000364932 ENSP00000328436 ENSP00000364929 ENSP00000345202 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
About this table Antibodies for ING1: Assays for ING1:
Protein
Domains/ Families for ING1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UK53 ProtoNet protein and cluster: Q9UK53
1 Blocks protein family : IPB001965 Zn-finger-like UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53 Similarity : Belongs to the ING familySimilarity : Contains 1 PHD-type zinc finger
Gene Function for ING1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
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siRNAs from
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_005537 Applied Biosystems Silencer ® siRNAs for ING1 Sigma-Aldrich siRNA and siRNA Panels for ING1 Sigma-Aldrich shRNA for ING1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_005537                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_005537                                  untagged cDNA clones in CMV expression vector (see all 5 ): AF181850  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005537 UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53 Function : Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulatingp53-dependent transcriptional activation. Implicated as a tumor suppressor gene
Genatlas biochemistry entry for ING1 :inhibitor of cell growth 1,located in the nucleus,underexpressed in breast cancer and neuroblastomacells
7 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Ing1) :4 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for ING1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for ING1 5/34 Interacting proteins for ING1 (Q9UK53 2 ENSP00000364929 3 ) via UniProtKB, MINT, and/or STRING (see all 34
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for ING1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ING1 1 Novoseek chemical compound relationship for ING1 gene
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
zinc
0.00
1
12632089 (1)
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Transcripts for ING1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_005537 Sigma-Aldrich siRNA and siRNA Panels for ING1 Sigma-Aldrich shRNA for ING1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_005537 NM_198217 NM_198218 NM_198219
REFSEQ mRNAs for ING1 gene (4 alternative transcripts): NM_005537.3 NM_198217.1 NM_198218.1 NM_198219.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005537 NM_198217 NM_198218 NM_198219
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_005537                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_005537                                  untagged cDNA clones in CMV expression vector (see all 5 ): AF181850  
Additional cDNA sequence: AB024401.1 AB024402.1 AB031269.1 AB037594.2 AF001954.1 AF044076.1 AF078835.1 AF149721.1 AF149722.1 AF149723.1 AF181849.1 AF181850.1 AJ310392.1 AK302353.1 BC018348.1 BC093942.1 BC093944.1
10 DOTS entries : DT.445761 DT.306030 DT.40271316 DT.95261599 DT.97859918 DT.91696048 DT.100745733 DT.100827727 DT.102843367 DT.75110001
24/461 AceView cDNA sequences (see all 461
):BM699852 AI056700 CB216294 BQ706137 AL043324 CK903371 BU621253 NM_198217 AA450055 AA371035 AI368102 BQ955656 AU132591 AI990313 AA632248 AK095260 BU620930 AI670736 AL541840 BM721522 AW469151 BM979895 AA452691 AA984395
highest scoring ESTs for ING1 :AB024401 AA045055 AA364494 AA450055 AA452691 AB024402 AB031269 AB037594 AF001954 AF044076
Unigene Cluster for ING1: Inhibitor of growth family, member 1 Hs.46700 [show with all ESTs ] Unigene Representative Sequence: NM_198219 GeneLoc Exon Structure 5 Ensembl transcripts including schematic representations : ENST00000375775
ENST00000375777
ENST00000333219
ENST00000375774
ENST00000338450
Expression for ING1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ING1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ING1 1 / 2 / 3
7 probe-sets matching ING1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.46700 Expression variation in blood from EXPOLDB for ING1
UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53 Tissue specificity : Isoform 2 was expressed in all normal tissues and cells examined, as well as inall breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, andkidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes.Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed inbreast, colon, kidney, melanocytes, breast cancer or melanoma cell lines
Orthologs for ING1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ING1 gene from 5/17 species (see all 17
)
About this table Species with no ortholog for ING1 ENSEMBL Gene Tree for ING1 Paralogs for ING1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ING1 gene INGX 2 ING2 2 ING3 2
SNPs/Variants for ING1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ING1 (up to first 250kb)
Disorders & Mutations for ING1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 601566 disorders : 275355 UniProtKB/Swiss-Prot: ING1_HUMAN, Q9UK53
Defects in ING1 are a cause of squamous cell carcinoma of the head and neck (HNSCC)[MIM:275355]
10/20 Novoseek disease relationships for ING1 gene (see all 20
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
tumors
54.01
119
11991811 (5), 10679922 (4), 12637159 (4), 17763999 (4) (see all 56 )
allelic loss
46.75
1
10866301 (1)
melanoma
33.71
35
11966686 (6), 12429989 (6), 12012016 (4), 15201991 (3) (see all 7 )
cancer
29.20
21
10498868 (2), 12835293 (2), 12835295 (1), 12523595 (1) (see all 15 )
glioma
25.25
18
12882685 (5), 14676120 (5), 10554029 (3), 12653407 (1) (see all 5 )
neoplastic transformation
23.72
4
8944021 (1), 9330636 (1)
carcinoma squamous cell
23.42
7
17805569 (2), 11287275 (2), 10866301 (1), 9330636 (1)
hepatocellular carcinoma
22.03
8
12523595 (2), 14642087 (2), 18450387 (1), 19085961 (1)
breast cancer
18.83
30
10626813 (5), 12835295 (4), 10754201 (4), 10498868 (4) (see all 8 )
brain tumors
14.42
12
14676120 (6), 12820433 (3)
About this table Human Genome Epidemiology Navigator: ING1 (1 document)
Medical News for ING1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ING1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/123 PubMed articles for ING1 gene (see all 123
): Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation. (PubMed id 8944021) 1, 2, 3, 4 Garkavtsev I.A.... Riabowol K. (1996) Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene. (PubMed id 10626813) 1, 3, 4 Jaeger D.... Chen Y.-T. (1999) The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control. (PubMed id 9440695) 1, 3, 4 Garkavtsev I.A.... Gudkov A.V. (1998) Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1). (PubMed id 9186514) 1, 2, 3 Garkavtsev I....Riabowol K. (1997) Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. (PubMed id 10866301) 1, 3, 4 Gunduz M.... Shimizu K. (2000) p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1. (PubMed id 10807544) 3, 4 Saito A....Horii A. (2000) Genomic organization of the suppressor gene for tumor growth ING1. (PubMed id 10779953) 3, 4 Baranova A.V.... Iankovskii N.K. (2000) Human inhibitor of growth 1 inhibits hepatoma cell growth and influences p53 stability in a variant-dependent manner. (PubMed id 19085961) 1, 3 Zhu Z....Zhu M. (2009) Decreased expression of the candidate tumor suppressor gene ING1 is associated with poor prognosis in advanced neuroblastomas. (PubMed id 15375504) 1, 3 Takahashi M....Nakagawara A. (2004) Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras. (PubMed id 15601862) 1, 3 Goeman F....Baniahmad A. (2005)
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Genome Databases showing ING1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ING1
(According to HUGE )
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--
Specialized Databases showing ING1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for ING1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for ING1:
Recombinant Proteins (ING1 ) Antibodies (ING1 )
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