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Aliases for ING1 Gene

Aliases for ING1 Gene

  • Inhibitor Of Growth Family Member 1 2 3 5
  • Growth Inhibitory Protein ING1 2 3
  • Tumor Suppressor ING1 2 3
  • Growth Inhibitor ING1 2 3
  • Inhibitor Of Growth Protein 1 3
  • Inhibitor Of Growth 1 2
  • P24ING1c 3
  • P33ING1b 3
  • P47ING1a 3
  • P33ING1 3
  • P47 3
  • P33 3

External Ids for ING1 Gene

Previous GeneCards Identifiers for ING1 Gene

  • GC13P109725
  • GC13P105752
  • GC13P110202
  • GC13P109063
  • GC13P110163
  • GC13P111365
  • GC13P091963

Summaries for ING1 Gene

Entrez Gene Summary for ING1 Gene

  • This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for ING1 Gene

ING1 (Inhibitor Of Growth Family Member 1) is a Protein Coding gene. Diseases associated with ING1 include Squamous Cell Carcinoma, Head And Neck and Squamous Cell Carcinoma. Among its related pathways are Senescence and Autophagy in Cancer and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include methylated histone binding. An important paralog of this gene is ING2.

UniProtKB/Swiss-Prot for ING1 Gene

  • Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

Gene Wiki entry for ING1 Gene

Additional gene information for ING1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ING1 Gene

Genomics for ING1 Gene

GeneHancer (GH) Regulatory Elements for ING1 Gene

Promoters and enhancers for ING1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I110710 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.6 1559 6.4 ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 CARS2 ING1 PIR46428 LOC105376684 ANKRD10-IT1 NAXD ANKRD10 GC13P110711
GH13I110873 Enhancer 1.4 FANTOM5 Ensembl ENCODE 10 +162.0 162004 1.7 HDGF PKNOX1 ZNF2 GATA2 KLF7 SP3 SP5 SMARCA4 NBN KDM1A ANKRD10 ING1 CARS2 NAXD RAB20 ANKRD10-IT1 LINC00346 GC13M110864 GC13P110892
GH13I110657 Enhancer 1.1 Ensembl ENCODE dbSUPER 12 -54.5 -54477 1.7 BATF FOXK2 ATF7 ETV6 IKZF2 RUNX3 NFE2L2 CBFB HLF JUNB CARS2 NAXD ING1 ANKRD10 COL4A2-AS2 COL4A2 GC13P110640 GC13P110711 GC13P110574
GH13I110675 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.8 -36.0 -36006 2 HDGF PKNOX1 RB1 BACH1 EBF1 BMI1 ZNF207 ETV6 IKZF2 RUNX3 CARS2 ING1 NAXD GC13P110711 GC13P110640 GC13P110574
GH13I110644 Enhancer 0.9 ENCODE dbSUPER 11.5 -67.8 -67762 0.8 CTCF USF1 BACH1 SIN3A ZIC2 RAD21 YY1 GLIS2 POLR2A SCRT2 CARS2 NAXD ING1 ANKRD10 GC13P110640 GC13P110711 GC13P110574
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ING1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ING1 gene promoter:

Genomic Locations for ING1 Gene

Genomic Locations for ING1 Gene
chr13:110,712,623-110,723,339
(GRCh38/hg38)
Size:
10,717 bases
Orientation:
Plus strand
chr13:111,365,083-111,373,421
(GRCh37/hg19)

Genomic View for ING1 Gene

Genes around ING1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ING1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ING1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ING1 Gene

Proteins for ING1 Gene

  • Protein details for ING1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK53-ING1_HUMAN
    Recommended name:
    Inhibitor of growth protein 1
    Protein Accession:
    Q9UK53
    Secondary Accessions:
    • O00532
    • O43658
    • Q53ZR3
    • Q5T9G8
    • Q5T9G9
    • Q5T9H0
    • Q5T9H1
    • Q9H007
    • Q9HD98
    • Q9HD99
    • Q9NS83
    • Q9P0U6
    • Q9UBC6
    • Q9UIJ1
    • Q9UIJ2
    • Q9UIJ3
    • Q9UIJ4
    • Q9UK52

    Protein attributes for ING1 Gene

    Size:
    422 amino acids
    Molecular mass:
    46738 Da
    Quaternary structure:
    • Interacts with H3K4me3 and to a lesser extent with H3K4me2. Interacts with TP53. Isoform 2 interacts with RSL1D1.
    SequenceCaution:
    • Sequence=AAB60879.1; Type=Frameshift; Positions=149; Evidence={ECO:0000305}; Sequence=AAG02579.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ING1 Gene

    Alternative splice isoforms for ING1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ING1 Gene

Post-translational modifications for ING1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ING1 Gene

Domains & Families for ING1 Gene

Gene Families for ING1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ING1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UK53

UniProtKB/Swiss-Prot:

ING1_HUMAN :
  • The PHD-type zinc finger mediates the binding to H3K4me3.
  • Belongs to the ING family.
Domain:
  • The PHD-type zinc finger mediates the binding to H3K4me3.
  • The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P).
Family:
  • Belongs to the ING family.
genes like me logo Genes that share domains with ING1: view

Function for ING1 Gene

Molecular function for ING1 Gene

GENATLAS Biochemistry:
inhibitor of cell growth 1,located in the nucleus,underexpressed in breast cancer and neuroblastoma cells
UniProtKB/Swiss-Prot Function:
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

Phenotypes From GWAS Catalog for ING1 Gene

Gene Ontology (GO) - Molecular Function for ING1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18388957
GO:0035064 methylated histone binding IDA 16728974
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ING1: view
genes like me logo Genes that share phenotypes with ING1: view

Human Phenotype Ontology for ING1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ING1 Gene

MGI Knock Outs for ING1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ING1 Gene

Localization for ING1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ING1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ING1 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ING1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS,IEA 10866301
genes like me logo Genes that share ontologies with ING1: view

Pathways & Interactions for ING1 Gene

genes like me logo Genes that share pathways with ING1: view

Pathways by source for ING1 Gene

1 Cell Signaling Technology pathway for ING1 Gene
1 BioSystems pathway for ING1 Gene

Gene Ontology (GO) - Biological Process for ING1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IEA --
GO:0007049 cell cycle IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0010941 regulation of cell death IEA --
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with ING1: view

No data available for SIGNOR curated interactions for ING1 Gene

Drugs & Compounds for ING1 Gene

(5) Drugs for ING1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ING1: view

Transcripts for ING1 Gene

Unigene Clusters for ING1 Gene

Inhibitor of growth family, member 1:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ING1 Gene

No ASD Table

Relevant External Links for ING1 Gene

GeneLoc Exon Structure for
ING1
ECgene alternative splicing isoforms for
ING1

Expression for ING1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ING1 Gene

Protein differential expression in normal tissues from HIPED for ING1 Gene

This gene is overexpressed in Heart (33.6) and Peripheral blood mononuclear cells (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ING1 Gene



Protein tissue co-expression partners for ING1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ING1 Gene:

ING1

SOURCE GeneReport for Unigene cluster for ING1 Gene:

Hs.46700

mRNA Expression by UniProt/SwissProt for ING1 Gene:

Q9UK53-ING1_HUMAN
Tissue specificity: Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.

Evidence on tissue expression from TISSUES for ING1 Gene

  • Nervous system(4.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ING1 Gene

Germ Layers:
  • ectoderm
Systems:
  • integumentary
Organs:
General:
  • skin
genes like me logo Genes that share expression patterns with ING1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ING1 Gene

Orthologs for ING1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ING1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ING1 33 34
  • 99.64 (n)
cow
(Bos Taurus)
Mammalia ING1 33 34
  • 87.41 (n)
mouse
(Mus musculus)
Mammalia Ing1 33 16 34
  • 85.78 (n)
rat
(Rattus norvegicus)
Mammalia Ing1 33
  • 84.47 (n)
dog
(Canis familiaris)
Mammalia ING1 33
  • 82.68 (n)
-- 34
  • 77 (a)
OneToMany
-- 34
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ING1 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ING1 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ING1 33 34
  • 75.32 (n)
lizard
(Anolis carolinensis)
Reptilia ING1 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ing1 33
  • 73.12 (n)
zebrafish
(Danio rerio)
Actinopterygii ing1 33 34
  • 67.5 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2460 33
fruit fly
(Drosophila melanogaster)
Insecta CG7379 33 34
  • 59.9 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO23 34 36
  • 20 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.8482 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10422 34
  • 29 (a)
OneToMany
Species where no ortholog for ING1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ING1 Gene

ENSEMBL:
Gene Tree for ING1 (if available)
TreeFam:
Gene Tree for ING1 (if available)

Paralogs for ING1 Gene

Paralogs for ING1 Gene

(2) SIMAP similar genes for ING1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ING1 Gene

genes like me logo Genes that share paralogs with ING1: view

Variants for ING1 Gene

Sequence variations from dbSNP and Humsavar for ING1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs121909250 pathogenic, Squamous cell carcinoma of the head and neck 110,719,736(+) G/C coding_sequence_variant, missense_variant
rs121909251 pathogenic, Squamous cell carcinoma of the head and neck 110,719,739(+) A/G coding_sequence_variant, missense_variant
rs121909252 pathogenic, Squamous cell carcinoma of the head and neck 110,719,667(+) C/A coding_sequence_variant, missense_variant
VAR_017420 Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355] p.Ala335Asp
VAR_017421 Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355] p.Cys358Ser

Structural Variations from Database of Genomic Variants (DGV) for ING1 Gene

Variant ID Type Subtype PubMed ID
nsv1044234 CNV gain 25217958
nsv1044340 CNV gain 25217958

Variation tolerance for ING1 Gene

Residual Variation Intolerance Score: 40.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ING1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ING1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ING1 Gene

Disorders for ING1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ING1 Gene - From: OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
squamous cell carcinoma, head and neck
  • hnscc
squamous cell carcinoma
  • epidermoid carcinoma
melanoma
  • malignant melanoma
breast cancer
  • breast cancer, familial
fibrosarcoma of bone
  • fibrosarcoma of the bone
- elite association - COSMIC cancer census association via MalaCards
Search ING1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ING1_HUMAN
  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. {ECO:0000269 PubMed:10866301}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ING1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ING1: view

No data available for Genatlas for ING1 Gene

Publications for ING1 Gene

  1. Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation. (PMID: 8944021) Garkavtsev I … Riabowol K (Nature genetics 1996) 2 3 4 22 58
  2. Genetic variation in healthy oldest-old. (PMID: 19680556) Halaschek-Wiener J … Brooks-Wilson AR (PloS one 2009) 3 22 44 58
  3. Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. (PMID: 18533182) Peña PV … Kutateladze TG (Journal of molecular biology 2008) 3 4 22 58
  4. DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. (PMID: 11481424) Nagashima M … Harris CC (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 22 58
  5. Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. (PMID: 10866301) Gunduz M … Shimizu K (Cancer research 2000) 3 4 22 58

Products for ING1 Gene

  • Addgene plasmids for ING1

Sources for ING1 Gene

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