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inactivation escape 1 (non-protein coding)
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Aliases
for INE1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): lncRNA
Quality score for this RNA gene is 3
| Aliases |
|---|
| Inactivation Escape 1 (Non-Protein Coding)1 2 | | NCRNA000101 2 | | DXS6974E3 |
| External Ids: | HGNC: 60601 | Entrez Gene: 85522 | Ensembl: ENSG000002249757 | OMIM: 3001645 | UniProtKB: O152253 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n385760 | |
Export aliases for INE1 gene to outside databasesPrevious GC identifers: GC0XU990270 GC0XP045890 GC0XP046110 GC0XP046820 GC0XP046950 GC0XP044774
Summaries
for INE1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for INE1:
X chromosome inactivation provides dosage compensation for the expression level of X-linked genes from the single X inmales and the two in females. This X chromosome gene is intronless and was identified because its transcriptionescapes X inactivation in females. This gene does not make a protein.(provided by RefSeq, May 2010)
|
Genomic Views
for INE1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the INE1 gene promoter:
p53 Brachyury HOXA5 Cart-1 ZIC2/Zic2 CUTL1 c-Ets-1 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for INE1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INE1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.4-p11.3 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.4-p11.3INE1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP047064: view genomic region
(about GC identifiers)
Start:
|
47,064,247 bp from pter |
End:
|
47,065,264 bp from pter |
Size:
|
1,018 bases |
Orientation:
|
plus strand |
|
Proteins
for INE1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: INE1_HUMAN, O15225 (See
protein sequence)Recommended Name: Putative inactivation escape 1 protein Size: 51 amino acids; 5365 Da
Caution: Product of a dubious gene prediction. Encoded in intron of UBA1
Secondary accessions: Q5JRR7 Q6NSX0Explore the universe of human proteins at neXtProt for INE1: NX_O15225
INE1 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000416095
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
-- | -- |
INE1 for ontologies About GeneDecksing
INE1 Antibody Products:
Assay Products for INE1: |
Protein
Domains /
Families
for INE1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O15225 |
Function
for INE1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for INE1:EST transcript from a gene escaping inactivation
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INE1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
-- | -- |
INE1 for ontologies About GeneDecksing
|
Pathways & Interactions
for INE1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INE1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
-- | -- |
INE1 for ontologies About GeneDecksing
|
Drugs & Compounds
for INE1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for INE1
Search CenterWatch for drugs/clinical trials and news about INE1 
|
Transcripts
for INE1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for INE1 gene: NM_003669.1 Unigene Cluster for INE1: Inactivation escape 1 (non-protein coding) Hs.657350 [show with all ESTs]Unigene Representative Sequence: NR_0246161 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000456273(uc004dhl.3)
Additional cDNA sequence: BC069671.1 BC069696.1 BC069772.1 BC112149.1 BC112175.1 NR_024616.1 Y10696.1 3 DOTS entries: DT.86853428 DT.91752333 DT.40312137 24/826 AceView cDNA sequences (see all 826): BE699861 CD674702 BQ068690 NM_003334 BF726043 BF149397 BQ438206 BQ718446 BE701773 AU124908 BQ641656 BU542121 CF143525 BE378821 BM806764 BM694877 BQ071461 BU782707 BE735567 F36171 CN482434 BM979323 BU902472 NM_153280
GeneLoc Exon Structure
|
Expression
for INE1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for INE1:none
INE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See INE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INE1
SOURCE GeneReport for Unigene cluster: Hs.657350
UniProtKB/Swiss-Prot: INE1_HUMAN, O15225Tissue specificity: Highly expressed in pancreas, heart and liver followed by brain, placenta, lung, skeletal muscleand kidney. Mostly expressed in females
SABiosciences Custom PCR Arrays for INE1
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INE1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat INE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INE1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INE1 |
Orthologs
for INE1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for INE1 (if available)
TreeFam Gene Tree for INE1 (if available) |
Paralogs
for INE1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for INE1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Locus Specific Mutation Databases (LSDB): INE1
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for INE1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
INE1 for disorders About GeneDecksing
OMIM gene information: 300164
OMIM disorders: --
1  disease for INE1: About MalaCardsx inactivation
Export disorders for INE1 gene to outside databases
|
Publications
for INE1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for INE1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with INE1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Escape from X inactivation of two new genes associated with DXS6974E and DXS7020E. (PubMed id 9244435)1, 2, 3 Esposito T.... Forabosco A. (1997)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Regulation of X-chromosome inactivation in development in mice and humans. (PubMed id 9618446)1 Goto T. and Monk M. (1998)
|
External Searches for INE1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing INE1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing INE1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing INE1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for INE1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for INE1 gene:
Search GeneIP for patents involving INE1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for INE1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INE1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INE1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INE1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INE1 |
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 |  |  |  | |
| | | | Search Tocris compounds for INE1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INE1 |
|  |  |  | | | | Search ThermoFisher Antibodies for INE1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat INE1 |
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