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IDO1 Gene

protein-coding GIFtS: 56

GC08P039891

indoleamine 2,3-dioxygenase 1
(Previous name: indoleamine-pyrrole 2,3 dioxygenase )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: IDO, INDO)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD107B ^²
EC 1.13.11.52 ^³
IDO ^², ³, ⁵
INDO ^², ⁵

Descriptions
Indoleamine-pyrrole 2,3-dioxygenase ^³
indole 2,3-dioxygenase ^²
indoleamine 2,3-dioxygenase 1 ^²
indoleamine-pyrrole 2,3 dioxygenase ^¹, ²

External Ids
HGNC: 6059¹
Entrez Gene: 3620²
UniProtKB: P14902³
Ensembl: ENSG00000131203⁷

Search outside databases for aliases for IDO1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IDO1:

Gamma-interferon (IFNG; MIM 147570) has an antiproliferative effect on many tumor cells and

inhibits intracellular pathogens such as Toxoplasma and Chlamydia, at least partly because of the

induction of indoleamine 2,3-dioxygenase (INDO; EC 1.13.11.52). This enzyme catalyzes the

degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine.[supplied by OMIM]

UniProtKB/Swiss-Prot: I23O_HUMAN, P14902

Function: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a

molecule of oxygen

Gene Wiki entry for IDO1 (Indoleamine_2%2C3-dioxygenase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12-p11 Ensembl cytogenetic band: 8p11.22 HGNC cytogenetic band: 8p12-p11

IDO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P039891: (about GC identifiers)

Start:	39,890,485 bp from pter
End:	39,905,107 bp from pter
Size:	14,623 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_007995.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: I23O_HUMAN, P14902 (See protein sequence)

Recommended Name: Indoleamine 2,3-dioxygenase

Size: 403 amino acids; 45326 Da

Cofactor: Binds 1 heme group per subunit

PDB structure from and Proteopedia :

2D0T (3D)

2D0U (3D)

REFSEQ proteins: NP_002155.1

ENSEMBL proteins:

ENSP00000253513

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant IDO1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Indoleamine 2, 3-dioxygenase)
	Human Recombinant Proteins from Abnova (INDO)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	EXP	16477023

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Antibodies for IDO1:

	Invitrogen Antibodies for IDO1
	Millipore Mono- and Polyclonal Antibodies for the study of IDO1
	Sigma-Aldrich Antibodies for IDO1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Indoleamine 2, 3-dioxygenase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (INDO)
	Novus Biologicals Antibodies for INDO

Assays for IDO1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P14902

ProtoNet protein and cluster: P14902

1 Blocks protein family: IPB000898 Indoleamine 2,3-dioxygenase

UniProtKB/Swiss-Prot: I23O_HUMAN, P14902

Similarity: Belongs to the indoleamine 2,3-dioxygenase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IDO1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (INDO)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002164

Applied Biosystems Silencer® siRNAs for IDO1

Sigma-Aldrich siRNA for IDO1

Sigma-Aldrich shRNA for IDO1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IDO1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002164
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002164
untagged cDNA clone in CMV expression vector: NM_002164

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002164

UniProtKB/Swiss-Prot: I23O_HUMAN, P14902

Function: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a

molecule of oxygen

Catalytic activity: D-tryptophan + O(2) = N-formyl-D-kynurenine

Catalytic activity: L-tryptophan + O(2) = N-formyl-L-kynurenine

Induction: By interferon gamma

Enzyme Number (IUBMB): EC 1.13.11.52

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ido1):

immune system

reproductive system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004833	tryptophan 2,3-dioxygenase activity	IEA	--
GO:0009055	electron carrier activity	TAS	2109605
GO:0016491	oxidoreductase activity	IEA	--
GO:0020037	heme binding	IEA	--
GO:0033754	indoleamine 2,3-dioxygenase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for IDO1 (Your Favorite Gene powered by Ingenuity)

Tryptophan Metabolism

GeneDecks IDO1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for IDO1

5/68 Interacting proteins for IDO1 (ENSP00000253513³ P14902²) via UniProtKB, MINT, and/or STRING (see all 68 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DDX24	Q9GZR7²	MINT-65410
PPP1R16A	Q96I34²	MINT-65182
IFNG	ENSP00000229135³	STRING (score=.987)
IL10	ENSP00000356066³	STRING (score=.976)
KYNU	ENSP00000264170³	STRING (score=.973)

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002666	positive regulation of T cell tolerance induction	IEA	--
GO:0002678	positive regulation of chronic inflammatory response	IEA	--
GO:0002830	positive regulation of T-helper 2 type immune response	IEA	--
GO:0007565	female pregnancy	TAS	9712583
GO:0019441	tryptophan catabolic process to kynurenine	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IDO1
10/35 Novoseek chemical compound relationships for IDO1 gene (see all 35 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
indoleamine	99.04	389	17942160 (2), 15063631 (2), 16394644 (2), 16686756 (2) (see all 99)
kynurenine	96.96	241	10756023 (6), 8293279 (5), 19327051 (5), 10731095 (4) (see all 99)
1-methyltryptophan	94.46	59	18418598 (5), 16887964 (3), 17605849 (2), 17999277 (2) (see all 23)
1-methyl-d-tryptophan	90.90	14	15281097 (1), 17114500 (1), 18832696 (1), 17945538 (1) (see all 8)
n-formylkynurenine	89.26	13	8288893 (1), 1591013 (1), 15206718 (1), 19275153 (1) (see all 13)
neopterin	82.06	17	15302611 (1), 17136028 (1), 7790043 (1), 15206718 (1) (see all 16)
quinolinic acid	82.05	19	17457312 (2), 18063923 (2), 14592780 (1), 18516521 (1) (see all 16)
indolamine	82.02	11	10206145 (2), 15516717 (1), 19079205 (1), 17157205 (1) (see all 10)
3-hydroxykynurenine	80.25	3	10731095 (1), 7617307 (1), 8817290 (1)
4-phenylimidazole	75.30	5	18665584 (2), 16477023 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IDO1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (INDO)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002164

Sigma-Aldrich siRNA for IDO1

Sigma-Aldrich shRNA for IDO1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002164

REFSEQ mRNAs for IDO1 gene:

NM_002164.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002164

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002164
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002164
                                 untagged cDNA clone in CMV expression vector: NM_002164

Additional cDNA sequence:

AK313259.1 AY221100.1 BC027882.1 CR591703.1 CR613807.1 CR614485.1 CR616634.1 CR621546.1

M34455.1 X17668.1

8 DOTS entries:

DT.408798 DT.100691410 DT.100788833 DT.65287506 DT.95330370 DT.92018039 DT.92451035 DT.95216114

24/86 AceView cDNA sequences (see all 86 ):

AY221100 AA478338 BQ007037 CD370496 CA432661 CB529600 CB118974 AL549011

AU137351 AL554455 BC027882 NM_002164 CB217134 X17668 AL545869 CD742761

CR614485 CR616634 CR621546 AL549895 BX113985 CD369108 BE466403 AI308058

Unigene Cluster for IDO1:

Indoleamine 2,3-dioxygenase 1

Hs.840 [show with all ESTs]

Unigene Representative Sequence: M34455

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000253513

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IDO1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IDO1

¹ / ²

5 probe-sets matching IDO1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
70099_g_at²	U95-D	1	1.00	1.00	0.98	0.93	--	--	--	--	--
36804_at²	U95-A	1	1.00	1.00	0.92	1.28	--	--	--	--	--
70097_at²	U95-D	1	0.31	1.00	0.89	0.82	--	--	--	--	--
210029_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
210029_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IDO1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGAAGATATA

SOURCE GeneReport for Unigene cluster: Hs.840

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IDO1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	INDO¹	--	indoleamine-pyrrole 2,3 dioxygenase	78.62(n) 68.18(a)	475574 XM_532793.2 XP_532793.1
chimpanzee (Pan troglodytes)	INDO¹	--	indoleamine-pyrrole 2,3 dioxygenase	99.26(n) 99.01(a)	464134 XM_519723.2 XP_519723.2
cow (Bos taurus)	INDO¹	--	indoleamine-pyrrole 2,3 dioxygenase	78.98(n) 70.6(a)	506281 XM_582707.3 XP_582707.3
rat (Rattus norvegicus)	Indo¹	--	indoleamine-pyrrole 2,3 dioxygenase	72.41(n) 63.8(a)	66029 NM_023973.1 NP_076463.1
mouse (Mus musculus)	Ido1⁵ Indo¹	8⁵	indoleamine 2,3-dioxygenase 1⁵ indoleamine-pyrrole 2,3 dioxygenase¹	72.24(n)¹ 62.53(a)¹	15930¹ NM_008324.1¹ NP_032350.1¹ AK033783⁵ BC049931⁵ (see all 6)

About this table Species with no ortholog for IDO1

ENSEMBL Gene Tree for IDO1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IDO1 gene

IDO2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/71 NCBI SNPs in IDO1 are shown (see all 71 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 46)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3808606^1,2	A,C,F,H	39888532(-)	`CAGGTC/TGTTAT`	1	--	ng5¹		9		NA EU EA WA	742
	rs3824259^1,2	A,C,F,H	39888750(-)	`TCAATG/TTTATC`	1	--	ng5¹		16		EU EA WA NA	1474
--	rs9298585^1,2	A,C	39888892(+)	`tctcgA/Ggctca`	1	--	ng5¹		0	--	--	--	--
	rs35059413^1,2	C,F	39890608(-)	`CATAGC/TGTGTG`	1	A/T	mis¹		5		NA EU EA WA	498
	rs10089084^1,2	F,H	39889106(+)	`GGATAG/CATTTA`	1	--	ng5¹		4		EU EA WA	416
--	rs4463407^1,2	H	39895507(+)	`AAATAT/GTGCTG`	1	S/I	mis¹		4		EU EA WA	420
	rs12545877^1,2	H	39895501(+)	`GCCAAG/AAAATA`	1	K/R	mis¹		4		EU EA WA	420
	rs12545878^1,2	C,H	39895535(+)	`TCCAAG/AAAACT`	1	K/K	syn¹ ese³		4		EU EA WA	420
	rs3739319^1,2	A,C,F,H	39904478(+)	`CCTCCG/ATATTT`	1	--	int¹		20		EA NA EU WA	2478
	rs7820268^1,2	A,C,F,H	39896686(+)	`TCAATC/TAAATA`	1	--	int¹		8		EA NA EU WA	626

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HapMap Linkage Disequilibrium images for IDO1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147435

10/71 Novoseek disease relationships for IDO1 gene (see all 71 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
bladder diseases	43.23	1	17537219 (1)
toxoplasmosis cerebral	40.28	1	8617321 (1)
infection chronic	40.20	4	17876564 (1), 17671174 (1), 17767193 (1), 19007906 (1)
nuclear cataract	38.19	1	16897708 (1)
autoimmune diseases	37.72	7	17430113 (3), 15206723 (1), 18847306 (1), 18660704 (1) (see all 5)
tumors	37.72	153	14678522 (7), 2116480 (6), 18056175 (6), 15132006 (4) (see all 67)
inflammation	37.41	28	18547472 (2), 18036645 (2), 18063923 (2), 17136028 (1) (see all 22)
immunodeficiency	36.44	9	16139256 (1), 17626075 (1), 16902147 (1), 17430111 (1) (see all 8)
spontaneous abortion	34.84	11	17321596 (3), 16421220 (2), 15206723 (1), 17430108 (1) (see all 5)
autoimmunity	32.97	6	16476191 (1), 19023117 (1), 17360980 (1), 17767193 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/477 PubMed articles for IDO1 gene (see all 477 ):

Molecular cloning, sequencing and expression of human interferon- gamma-inducible indoleamine 2,3-dioxygenase cDNA. (PubMed id 2109605)^{2, 3, 4} Dai W. and Gupta S.L. (1990)
Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase. (PubMed id 16477023)^{1, 3, 4} Sugimoto H.... Shiro Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Localization of indoleamine 2,3-dioxygenase gene (INDO) to chromosome 8p12-->p11 by fluorescent in situ hybridization. (PubMed id 8404046)^{2, 3} Najfeld V....Gupta S.L. (1993)
Gene structure of human indoleamine 2,3-dioxygenase. (PubMed id 1449503)^{3, 4} Kadoya A.... Kido R. (1992)
Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA. (PubMed id 2326172)^{3, 4} Tone S....Kido R. (1990)
Astrocyte indoleamine 2,3-dioxygenase is induced by the TLR3 ligand poly(I:C): mechanism of induction and role in antiviral response. (PubMed id 17626075)^{1, 3} Suh H.S....Lee S.C. (2007)
Indoleamine-dioxygenase is expressed in human decidua at the time maternal tolerance is established. (PubMed id 17321596)^{1, 3} von Rango U....Classen-Linke I. (2007)
Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma. (PubMed id 19058839)^{1, 3} Maneechotesuwan K....Wongkajornsilp A. (2009)
Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells. (PubMed id 18299324)^{1, 3} Maghzal G.J....Stocker R. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3620	HGNC: 6059	AceView: INDO	Ensembl:ENSG00000131203	euGenes: HUgn3620
ECgene: IDO1	H-InvDB: IDO1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for IDO1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IDO1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IDO1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IDO1		Antibodies for IDO1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IDO1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (INDO)
	Antibodies (INDO)
	Chimera RNAi (INDO)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Indoleamine 2, 3-dioxygenase)
	Antibodies (Indoleamine 2, 3-dioxygenase)

Search OriGene for IDO1

Search Tocris compounds for IDO1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for INDO

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IDO1 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for IDO1

Summaries
for IDO1

Genomic Location
for IDO1

Proteins
for IDO1

Protein Domains/
Families
for IDO1

Gene Function
for IDO1

Pathways & Interactions
for IDO1

Drugs & Compounds
for IDO1

Transcripts
for IDO1

Expression
for IDO1

Orthologs
for IDO1

Paralogs
for IDO1

SNPs/Variants
for IDO1

Disorders & Mutations
for IDO1

Medical News
for IDO1

Publications
for IDO1

Search for IDO1

Genome Databases showing IDO1

Other Databases showing IDO1

Specialized Databases showing IDO1

Licensable Technologies
for IDO1

Services
for IDO1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IDO1 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor IDO1

Summariesfor IDO1

Genomic Locationfor IDO1

Proteinsfor IDO1

Protein Domains/Familiesfor IDO1

Gene Functionfor IDO1

Pathways & Interactionsfor IDO1

Drugs & Compoundsfor IDO1

Transcriptsfor IDO1

Expression for IDO1

Orthologsfor IDO1

Paralogsfor IDO1

SNPs/Variantsfor IDO1

Disorders & Mutationsfor IDO1

Medical Newsfor IDO1

Publicationsfor IDO1

Search for IDO1

Genome Databases showing IDO1

Other Databases showing IDO1

Specialized Databases showing IDO1

Licensable Technologiesfor IDO1

Servicesfor IDO1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IDO1

Summaries
for IDO1

Genomic Location
for IDO1

Proteins
for IDO1

Protein Domains/
Families
for IDO1

Gene Function
for IDO1

Pathways & Interactions
for IDO1

Drugs & Compounds
for IDO1

Transcripts
for IDO1

Expression
for IDO1

Orthologs
for IDO1

Paralogs
for IDO1

SNPs/Variants
for IDO1

Disorders & Mutations
for IDO1

Medical News
for IDO1

Publications
for IDO1

Licensable Technologies
for IDO1

Services
for IDO1