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INCENP Gene

protein-coding   GIFtS: 60
GCID: GC11P061891

Inner Centromere Protein Antigens 135/155kDa

(Previous names: inner centromere protein antigens (135kD, 155kD))
  See INCENP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inner Centromere Protein Antigens 135/155kDa1 2
Inner Centromere Protein Antigens (135kD, 155kD)1
Binds And Activates Aurora-B And -C In Vivo And In Vitro2
Chromosomal Passenger Protein2
Inner Centromere Protein2
Inner Centromere Protein INCENP2

External Ids:    HGNC: 60581   Entrez Gene: 36192   Ensembl: ENSG000001495037   OMIM: 6044115   UniProtKB: Q9NQS73   

Export aliases for INCENP gene to outside databases

Previous GC identifers: GC11U990069 GC11P063467 GC11P062142 GC11P061666 GC11P061648 GC11P058219


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INCENP Gene:
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding
centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The
constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141),
and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to
the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 (PubMed 8088460)). These
include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs
(e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke,
1991 (PubMed 1860899)), the initial members of the passenger protein group, display a broad localization along
chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle
progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular
bridge, where they are discarded after cytokinesis (Cutts et al., 1999 (PubMed 10369859)).(supplied by OMIM, Mar
2008)

GeneCards Summary for INCENP Gene:
INCENP (inner centromere protein antigens 135/155kDa) is a protein-coding gene. Diseases associated with INCENP include graham little-piccardi-lassueur syndrome, and roberts syndrome.

UniProtKB/Swiss-Prot: INCE_HUMAN, Q9NQS7
Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.
The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and
segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts
through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore
localization of BUB1

Gene Wiki entry for INCENP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INCENP gene promoter:
         STAT1   RFX1   Pbx1a   STAT1beta   C/EBPalpha   STAT1alpha   E47   FAC1   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): INCENP promoter sequence
   Search Chromatin IP Primers for INCENP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INCENP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

INCENP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INCENP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P061891:  view genomic region     (about GC identifiers)

Start:
61,891,445 bp from pter      End:
61,920,635 bp from pter
Size:
29,191 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: INCE_HUMAN, Q9NQS7 (See protein sequence)
Recommended Name: Inner centromere protein  
Size: 918 amino acids; 105429 Da
Subunit: Homodimer or heterodimer. Interacts with H2AFZ (By similarity). Interacts with CBX3. Interacts with
tubulin beta chain. Interacts with AURKB and AURKC. Component of the chromosomal passenger complex (CPC) composed
of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with EVI5. Interacts with CDCA8
and BIRC5; interaction is direct. Interacts with CBX5; POGZ and INCENP compete for interaction with CBX5.
Interacts with POGZ. Interacts with JTB
Caution: PubMed:11139336 experiments have been carried out partly in chicken and partly in human
2 PDB 3D structures from and Proteopedia for INCENP:
2QFA (3D)        4AF3 (3D)    
Secondary accessions: A8MQD2 Q5Y192
Alternative splicing: 2 isoforms:  Q9NQS7-1   Q9NQS7-2   

Explore the universe of human proteins at neXtProt for INCENP: NX_Q9NQS7

Explore proteomics data for INCENP at MOPED

Post-translational modifications: 

  • Phosphorylation by AURKB at its C-terminal part is important for AURKB activation by INCENP1
  • Ubiquitination2 at Lys51, Lys321, Lys602
  • Modification sites at PhosphoSitePlus

  • See INCENP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035784.1  NP_064623.2  

    ENSEMBL proteins: 
     ENSP00000378295   ENSP00000433100   ENSP00000278849  
    Reactome Protein details: Q9NQS7

    INCENP Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant INCENP Protein
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    Cloud-Clone Corp. Proteins for INCENP

     
    Search eBioscience for Proteins for INCENP 

    INCENP Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of INCENP
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    Novus Biologicals INCENP Antibodies
    Abcam antibodies for INCENP
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    LSBio Antibodies in human, mouse, rat for INCENP

    INCENP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for INCENP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INCENP
    Cloud-Clone Corp. CLIAs for INCENP
    Search eBioscience for ELISAs for INCENP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR022006 INCENP_N
     IPR005635 Inner_centromere_prot_ARK-bd

    Graphical View of Domain Structure for InterPro Entry Q9NQS7

    ProtoNet protein and cluster: Q9NQS7

    1 Blocks protein domain: IPB005635 Inner centromere protein

    UniProtKB/Swiss-Prot: INCE_HUMAN, Q9NQS7
    Similarity: Belongs to the INCENP family


    Find genes that share domains with INCENP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INCE_HUMAN, Q9NQS7
    Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.
    The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and
    segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts
    through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore
    localization of BUB1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14610074
         
    Find genes that share ontologies with INCENP           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for INCENP:
     Cell division defect  Decreased cell number, increas  Decreased viability of wild-ty  Increased cell number in G2M,  
     Increased cilium length after   Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Incenp):
     embryogenesis  mortality/aging 

    Find genes that share phenotypes with INCENP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Incenptm1Khac for INCENP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INCENP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INCENP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INCENP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INCENP

    miRNA
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    miRTarBase miRNAs that target INCENP:
    hsa-mir-181a-5p (MIRT025087), hsa-mir-423-3p (MIRT042486), hsa-mir-142-3p (MIRT021587)

    Block miRNA regulation of human, mouse, rat INCENP using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate INCENP:
    hsa-miR-214 hsa-miR-185* hsa-miR-2355-3p hsa-miR-1252 hsa-miR-1324 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidINCENP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat INCENP

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): INCENP (NM_020238)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INCENP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INCENP
    Addgene plasmids for INCENP 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INCENP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INCE_HUMAN, Q9NQS7: Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Nucleus. Chromosome, centromere,
    kinetochore. Note=Localizes to inner kinetochore. Localizes on chromosome arms and inner centromeres from
    prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through
    cytokinesis. Colocalizes with AURKB at mitotic chromosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA11084331
    GO:0000776kinetochore IDA16760428
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0000795synaptonemal complex ----
    GO:0000800lateral element IEA--

    Find genes that share ontologies with INCENP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for INCENP About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4Aurora B signaling
    Aurora B signaling
    Aurora C signaling0.00
    5Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32


    Find genes that share SuperPaths with INCENP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for INCENP
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for INCENP
        Cell cycle Chromosome condensation in prometaphase

    4 BioSystems Pathways for INCENP
        PLK1 signaling events
    Aurora C signaling
    Aurora B signaling
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    3 Reactome Pathways for INCENP
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INCENP
    Interactions:

        GeneGlobe Interaction Network for INCENP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for INCENP (Q9NQS71, 2, 3 ENSP000003782954) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AURKBQ96GD41, 2, 3, ENSP000003139504EBI-307907,EBI-624291 MINT-77928 I2D: score=4 STRING: ENSP00000313950
    CDCA8Q53HL21, 3, ENSP000003161214EBI-307907,EBI-979174 I2D: score=3 STRING: ENSP00000316121
    BIRC5O153921, 2, 3, ENSP000003016334EBI-307907,EBI-518823 MINT-4509563 MINT-4509570 MINT-77929 I2D: score=4 STRING: ENSP00000301633
    CBX5P459731, 3, ENSP000002098754EBI-307907,EBI-78219 I2D: score=3 STRING: ENSP00000209875
    H2AFZP0C0S53, ENSP000002964174I2D: score=2 STRING: ENSP00000296417
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0000910cytokinesis IMP16239925
    GO:0007059chromosome segregation IMP16239925
    GO:0007067mitosis IEA--

    Find genes that share ontologies with INCENP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INCENP (INCE)

    1 DrugBank Compound for INCENP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine-- --target--10592235

    3 Novoseek inferred chemical compound relationships for INCENP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paclitaxel 23.6 3 19951914 (2), 17699588 (1)
    threonine 21.2 1 16571674 (1)
    serine 12.4 1 16571674 (1)



    Find genes that share compounds with INCENP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for INCENP gene (2 alternative transcripts): 
    NM_001040694.1  NM_020238.2  

    Unigene Cluster for INCENP:

    Inner centromere protein antigens 135/155kDa
    Hs.142179  [show with all ESTs]
    Unigene Representative Sequence: NM_001040694
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394818(uc009ynw.1 uc001nsw.1 uc001nsx.1) ENST00000533896
    ENST00000278849 ENST00000528037(uc009ynv.3) ENST00000528375 ENST00000531099

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate INCENP:
    hsa-miR-214 hsa-miR-185* hsa-miR-2355-3p hsa-miR-1252 hsa-miR-1324 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidINCENP 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for INCENP 
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      QuantiTect SYBR Green Assays in human, mouse, rat INCENP
      QuantiFast Probe-based Assays in human, mouse, rat INCENP

    Additional mRNA sequence: 

    AF282265.1 AK056195.1 AK307633.1 AK310714.1 AY714053.1 BC032678.1 BC098576.1 BC111732.1 

    3 DOTS entries:

    DT.206959  DT.91940121  DT.95263802 

    Selected AceView cDNA sequences (see all 54):

    N46208 BP359042 AI280357 AA252884 CR599315 AA253422 BM853659 AI924134 
    AA789124 BP355762 BP354754 BQ277988 AF282265 BM550428 BP351552 AA825487 
    BU931247 CB267478 AI222734 BP355738 BF885443 AI290465 CO246074 BM922517 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for INCENP    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b
    SP1:                                                                                -                       -               
    SP2:                                                                                                                        
    SP3:                                                                                -                                       
    SP4:        -                                                                                                               


    ECgene alternative splicing isoforms for INCENP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INCENP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    INCENP Expression
    About this image


    INCENP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Mesencephalic Ventricular Zone
    INCENP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INCENP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.142179
        Custom PCR Arrays for INCENP
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INCENP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INCENP gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Incenp1 , 5 inner centromere protein1, 5 77.3(n)1
    72.58(a)1
      19 (6.10 cM)5
    163191  NM_016692.31  NP_057901.21 
     98722975 
    chicken
    (Gallus gallus)
    Aves INCENP1 inner centromere protein antigens 135/155kDa 58.26(n)
    53.85(a)
      396270  NM_205330.1  NP_990661.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    51(a)
    43(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    3(73727883-73732099)
    GL343235.1(2331069-2354574)
    African clawed frog
    (Xenopus laevis)
    Amphibia U95094.22   -- 77.35(n)    U95094.2 
    zebrafish
    (Danio rerio)
    Actinopterygii INCENP6
    inner centromere protein antigens 135/155kDa
    33(a)
    1 ↔ 1
    25(3555053-3581279) ENSDARG00000077270
    fruit fly
    (Drosophila melanogaster)
    Insecta Incenp6
    Inner centromere protein
    17(a)
    1 ↔ 1
    2R(3165972-3169066)
    worm
    (Caenorhabditis elegans)
    Secernentea icp-16
    Protein ICP-1 (icp-1) mRNA, complete cds
    21(a)
    1 ↔ 1
    I(2304470-2306816) WBGene00002047


    ENSEMBL Gene Tree for INCENP (if available)
    TreeFam Gene Tree for INCENP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for INCENP (see all 893)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38623891,2
    C,F,A,H--61889542(-) TGTTCC/TCAGGT 2 -- us2k124Minor allele frequency- T:0.34NS EA NA WA 2488
    rs38623901,2
    C,F,A--61889595(-) AATCTT/CGAAGA 2 -- us2k19Minor allele frequency- C:0.32NA WA EA 370
    rs1384311991,2
    --61889681(+) CAGCAG/TCAATT 2 -- us2k10--------
    rs1429056571,2
    --61889682(+) AGCAGC/TAATTC 2 -- us2k10--------
    rs1915053861,2
    --61889735(+) TATGCA/GCTAGA 2 -- us2k10--------
    rs1507470621,2
    --61889781(+) AATACC/GACTAA 2 -- us2k10--------
    rs1836531901,2
    --61889837(+) GGGGCA/GGAGGT 2 -- us2k10--------
    rs122735611,2
    C,F,H--61889960(+) CACACT/CCCGTT 2 -- us2k111Minor allele frequency- C:0.08NS EA NA WA 1210
    rs2019127221,2
    C--61890174(+) GCTAA-/TTTTTTT 2 -- us2k10--------
    rs1124365031,2
    C,F--61890433(+) CTTGTC/GTTTCC 2 -- us2k12Minor allele frequency- G:0.09CSA WA 120

    HapMap Linkage Disequilibrium report for INCENP (61891445 - 61920635 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for INCENP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744601CNV Deletion23290073
    esv2480486CNV Deletion19546169
    esv2658380CNV Deletion23128226
    nsv897620CNV Loss21882294
    esv997129CNV Gain20482838
    esv2751033CNV Gain17911159
    dgv391e1CNV Complex17122850
    nsv7219OTHER Inversion18451855
    esv259724OTHER Complex20981092
    esv259660OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INCENP
    DNA2.0 Custom Variant and Variant Library Synthesis for INCENP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604411    OMIM disorders: --

    2 diseases for INCENP:    
    About MalaCards
    graham little-piccardi-lassueur syndrome    roberts syndrome

    1 disease from the University of Copenhagen DISEASES database for INCENP:
    Roberts syndrome

    Find genes that share disorders with INCENP           About GenesLikeMe

    2 Novoseek inferred disease relationships for INCENP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma 0 4 16402339 (2), 19221486 (1)
    cancer 0 3 19221486 (1), 18752045 (1)


    Export disorders for INCENP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INCENP gene, integrated from 10 sources (see all 140):
    (articles sorted by number of sources associating them with INCENP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. (PubMed id 11453556)1, 2, 3, 9 Adams R.R.... Earnshaw W.C. (Chromosoma 2001)
    2. Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. (PubMed id 14610074)1, 2, 9 Wheatley S.P.... Earnshaw W.C. (J. Biol. Chem. 2004)
    3. Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. (PubMed id 15316025)1, 2, 9 Li X.... Urano T. (J. Biol. Chem. 2004)
    4. Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. (PubMed id 12925766)1, 2, 9 Honda R.... Nigg E.A. (Mol. Biol. Cell 2003)
    5. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. (PubMed id 15249581)1, 2, 9 Gassmann R.... Earnshaw W.C. (J. Cell Biol. 2004)
    6. Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. (PubMed id 17956729)1, 2, 9 Jeyaprakash A.A....Conti E. (Cell 2007)
    7. EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. (PubMed id 16764853)1, 2, 9 Faitar S.L.... Cowell J.K. (Exp. Cell Res. 2006)
    8. Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation. (PubMed id 1860899)1, 3, 9 Earnshaw W.C. and Cooke C.A. (J. Cell. Sci. 1991)
    9. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PubMed id 20562864)1, 2 Nozawa R.S.... Obuse C. (Nat. Cell Biol. 2010)
    10. Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. (PubMed id 16760428)1, 2 Qi W.... Yu H. (Mol. Biol. Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3619 HGNC: 6058 AceView: INCENP Ensembl:ENSG00000149503 euGenes: HUgn3619
    ECgene: INCENP H-InvDB: INCENP

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for INCENP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for INCENP gene:
    Search GeneIP for patents involving INCENP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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