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Aliases for INCA1 Gene

Aliases for INCA1 Gene

  • Inhibitor Of CDK, Cyclin A1 Interacting Protein 1 2 3 5
  • Inhibitor Of CDK Interacting With Cyclin A1 4
  • Protein INCA1 3
  • HSD45 3

External Ids for INCA1 Gene

Previous GeneCards Identifiers for INCA1 Gene

  • GC17M005091
  • GC17M004832
  • GC17M004891

Summaries for INCA1 Gene

GeneCards Summary for INCA1 Gene

INCA1 (Inhibitor Of CDK, Cyclin A1 Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include cyclin binding and cyclin-dependent protein serine/threonine kinase inhibitor activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INCA1 Gene

Genomics for INCA1 Gene

Regulatory Elements for INCA1 Gene

Enhancers for INCA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G004965 1.4 ENCODE dbSUPER 25.1 +29.3 29306 5.4 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 SPAG7 ZNF232 INCA1 CHRNE LOC100130950 LOC101927979 KIF1C DHX33 CAMTA2 RNF167
GH17G004502 1.4 Ensembl ENCODE dbSUPER 13.8 +493.3 493280 4.5 HDGF PKNOX1 FOXA2 ZFP64 BMI1 TCF12 ZNF121 FOS EGR2 ZNF680 LOC101927979 ZNF594 ZNF232 LOC100130950 LOC105371492 INCA1 DHX33 MYBBP1A GC17M004505 PIR54894
GH17G005041 1.3 Ensembl ENCODE 11.7 -44.5 -44548 1.4 PKNOX1 AGO1 ARID4B SIN3A YY1 TCF12 GLIS2 KLF7 FOS DEK SPAG7 ENO3 ENSG00000234203 KIF1C INCA1 CAMTA2 ZFP3 PFN1 SLC52A1 LOC105371502
GH17G005047 1.2 FANTOM5 ENCODE 10.8 -49.6 -49641 0.8 HDAC1 PKNOX1 SREBF2 ARID4B ZNF335 ZNF366 SCRT2 ZNF207 PCBP1 CREM CAMTA2 ENO3 SPAG7 ZFP3 PFN1 INCA1 KIF1C USP6 SLC52A1 LOC105371502
GH17G005044 1.1 ENCODE 11.7 -47.3 -47332 2.3 HDGF PKNOX1 FOXA2 ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 SPAG7 CAMTA2 ENO3 NUP88 ENSG00000234203 KIF1C INCA1 PFN1 ZFP3 ZNF232
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INCA1 on UCSC Golden Path with GeneCards custom track

Promoters for INCA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090571 -278 2001 MLX ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 SP3 SP5

Genomic Location for INCA1 Gene

Chromosome:
17
Start:
4,988,130 bp from pter
End:
4,997,922 bp from pter
Size:
9,793 bases
Orientation:
Minus strand

Genomic View for INCA1 Gene

Genes around INCA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INCA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INCA1 Gene

Proteins for INCA1 Gene

  • Protein details for INCA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VD86-INCA1_HUMAN
    Recommended name:
    Protein INCA1
    Protein Accession:
    Q0VD86
    Secondary Accessions:
    • Q6J273
    • Q6PKN9

    Protein attributes for INCA1 Gene

    Size:
    236 amino acids
    Molecular mass:
    26817 Da
    Quaternary structure:
    • Interacts with CCNA1. Identified in a complex with CCNA1 and CDK2. Interacts with ZNF16; the interaction inhibits INCA1 activity and induces the cell cycle process.

    Alternative splice isoforms for INCA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INCA1 Gene

Post-translational modifications for INCA1 Gene

  • Phosphorylated when part of a complex with CCNA1 and CDK2. Strongly phosphorylated by CDK2 on its C-terminal region spanning amino acid 149-221. Less intensively phosphorylated by CDK2 on its first 75 amino acid residues.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INCA1 Gene

Domains & Families for INCA1 Gene

Protein Domains for INCA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INCA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0VD86

UniProtKB/Swiss-Prot:

INCA1_HUMAN :
  • Belongs to the INCA family.
Family:
  • Belongs to the INCA family.
genes like me logo Genes that share domains with INCA1: view

No data available for Gene Families for INCA1 Gene

Function for INCA1 Gene

Gene Ontology (GO) - Molecular Function for INCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IDA 21540187
GO:0005515 protein binding IPI 21874239
GO:0030332 cyclin binding IDA 21540187
genes like me logo Genes that share ontologies with INCA1: view
genes like me logo Genes that share phenotypes with INCA1: view

Animal Models for INCA1 Gene

MGI Knock Outs for INCA1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for INCA1 Gene

Localization for INCA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INCA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INCA1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for INCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA,IEA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with INCA1: view

Pathways & Interactions for INCA1 Gene

SuperPathways for INCA1 Gene

No Data Available

Pathways by source for INCA1 Gene

1 GeneTex pathway for INCA1 Gene

Gene Ontology (GO) - Biological Process for INCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IBA,IEA --
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA 21540187
GO:2001235 positive regulation of apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with INCA1: view

No data available for SIGNOR curated interactions for INCA1 Gene

Transcripts for INCA1 Gene

mRNA/cDNA for INCA1 Gene

(12) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INCA1 Gene

Inhibitor of CDK, cyclin A1 interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INCA1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for INCA1 Gene

GeneLoc Exon Structure for
INCA1
ECgene alternative splicing isoforms for
INCA1

Expression for INCA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INCA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INCA1 Gene

This gene is overexpressed in Testis (x11.0).

Protein differential expression in normal tissues from HIPED for INCA1 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for INCA1 Gene



Protein tissue co-expression partners for INCA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of INCA1 Gene:

INCA1

SOURCE GeneReport for Unigene cluster for INCA1 Gene:

Hs.658926

mRNA Expression by UniProt/SwissProt for INCA1 Gene:

Q0VD86-INCA1_HUMAN
Tissue specificity: Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors.
genes like me logo Genes that share expression patterns with INCA1: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for INCA1 Gene

Orthologs for INCA1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for INCA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INCA1 34 35
  • 99.28 (n)
cow
(Bos Taurus)
Mammalia INCA1 34 35
  • 81.62 (n)
rat
(Rattus norvegicus)
Mammalia Inca1 34
  • 77.12 (n)
mouse
(Mus musculus)
Mammalia Inca1 34 16 35
  • 76.19 (n)
dog
(Canis familiaris)
Mammalia INCA1 34 35
  • 75.23 (n)
Species where no ortholog for INCA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INCA1 Gene

ENSEMBL:
Gene Tree for INCA1 (if available)
TreeFam:
Gene Tree for INCA1 (if available)

Paralogs for INCA1 Gene

No data available for Paralogs for INCA1 Gene

Variants for INCA1 Gene

Sequence variations from dbSNP and Humsavar for INCA1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000464490 -- 4,999,457(+) CCTTT(C/T)CTCTC intron-variant, upstream-variant-2KB
rs1000725177 -- 4,999,629(+) TCTCT(C/G/T)TCTGT intron-variant, upstream-variant-2KB
rs1000917238 -- 4,999,485(+) GCATG(A/C)CCTCA intron-variant, upstream-variant-2KB
rs1001073394 -- 4,993,984(+) CCAGG(C/T)TGGTC intron-variant
rs1001194001 -- 4,988,534(+) AGGGG(G/T)CTCCA nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for INCA1 Gene

Variant ID Type Subtype PubMed ID
dgv5431n54 CNV loss 21841781
esv3639799 CNV loss 21293372
nsv574273 CNV gain 21841781
nsv833349 CNV loss 17160897
nsv833350 CNV loss 17160897

Variation tolerance for INCA1 Gene

Residual Variation Intolerance Score: 65.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INCA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INCA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INCA1 Gene

Disorders for INCA1 Gene

Relevant External Links for INCA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INCA1

No disorders were found for INCA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INCA1 Gene

Publications for INCA1 Gene

  1. A novel testis protein, RSB-66, interacting with INCA1 (inhibitor of Cdk interacting with cyclin A1). (PMID: 18756329) Chen X. … Wang L. (Biochem. Cell Biol. 2008) 2 3 22 64
  2. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PMID: 15159402) Diederichs S. … Mueller-Tidow C. (J. Biol. Chem. 2004) 2 3 4 64
  3. Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1. (PMID: 21874239) Li X.B. … Zhang J.W. (Mol Med Rep 2011) 3 4 64
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for INCA1 Gene

Sources for INCA1 Gene

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