Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



INCA1 Gene

protein-coding   GIFtS: 42
GCID: GC17M004891

Inhibitor Of CDK, Cyclin A1 Interacting Protein 1

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Inhibitor Of CDK, Cyclin A1 Interacting Protein 11 2
Protein INCA12
Inhibitor Of CDK Interacting With Cyclin A13

External Ids:    HGNC: 322241   Entrez Gene: 3883242   Ensembl: ENSG000001963887   UniProtKB: Q0VD863   

Export aliases for INCA1 gene to outside databases

Previous GC identifers: GC17M005091 GC17M004832


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for INCA1 Gene:
INCA1 (inhibitor of CDK, cyclin A1 interacting protein 1) is a protein-coding gene. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and cyclin binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INCA1 gene promoter:
         E2F-4   E2F-3a   E2F-5   SREBP-1c   E2F-2   Nkx2-5   SREBP-1b   E2F   SREBP-1a   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINCA1 promoter sequence
   Search Chromatin IP Primers for INCA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INCA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.2

INCA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INCA1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M004891:  view genomic region     (about GC identifiers)

Start:
4,891,425 bp from pter      End:
4,900,905 bp from pter
Size:
9,481 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: INCA1_HUMAN, Q0VD86 (See protein sequence)
Recommended Name: Protein INCA1  
Size: 236 amino acids; 26817 Da
Subunit: Interacts with CCNA1. Identified in a complex with CCNA1 and CDK2. Interacts with ZNF16; the interaction
inhibits INCA1 activity and induces the cell cycle process
Secondary accessions: Q6J273 Q6PKN9
Alternative splicing: 2 isoforms:  Q0VD86-1   Q0VD86-2   

Explore the universe of human proteins at neXtProt for INCA1: NX_Q0VD86

Explore proteomics data for INCA1 at MOPED

Post-translational modifications: 

  • Phosphorylated when part of a complex with CCNA1 and CDK2. Strongly phosphorylated by CDK2 on its C-terminal
    region spanning amino acid 149-221. Less intensively phosphorylated by CDK2 on its first 75 amino acid residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See INCA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001161457.1  NP_001161458.1  NP_001161459.1  NP_998891.2  

    ENSEMBL proteins: 
     ENSP00000347129   ENSP00000461844   ENSP00000460673   ENSP00000458316   ENSP00000380041  

    INCA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for INCA1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for INCA1
    GenScript Custom Purified and Recombinant Proteins Services for INCA1
    Novus Biologicals INCA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INCA1

     
    Search eBioscience for Proteins for INCA1 

    INCA1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for INCA1
    Novus Biologicals INCA1 Antibody
    Search for Antibodies for INCA1 at Abcam
    Cloud-Clone Corp. Antibodies for INCA1
    Search ThermoFisher Antibodies for INCA1
    LSBio Antibodies in human, mouse, rat for INCA1

    INCA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for INCA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for INCA1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INCA1
    Cloud-Clone Corp. CLIAs for INCA1
    Search eBioscience for ELISAs for INCA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR026238 INCA1

    Graphical View of Domain Structure for InterPro Entry Q0VD86

    ProtoNet protein and cluster: Q0VD86

    UniProtKB/Swiss-Prot: INCA1_HUMAN, Q0VD86
    Similarity: Belongs to the INCA family


    Find genes that share domains with INCA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity IDA--
    GO:0005515protein binding IPI--
    GO:0030332cyclin binding IDA--
         
    Find genes that share ontologies with INCA1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for INCA1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Inca1):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with INCA1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INCA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INCA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INCA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INCA1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat INCA1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate INCA1
    SwitchGear 3'UTR luciferase reporter plasmidINCA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INCA1
    Predesigned siRNA for gene silencing in human, mouse, rat INCA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for INCA1

    Clone
    Products:
         
    OriGene clones in human, mouse for INCA1 (see all 19)
    OriGene ORF clones in mouse, rat for INCA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): INCA1 (NM_213726)
    Sino Biological Human cDNA Clone for INCA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INCA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INCA1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for INCA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for INCA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INCA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    INCA1_HUMAN, Q0VD86: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with INCA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INCA1
    Interactions:

        Search GeneGlobe Interaction Network for INCA1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for INCA1 (Q0VD861, 3 ENSP000003471294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK2P249413, ENSP000002669704I2D: score=1 STRING: ENSP00000266970
    CCNA1P783963, ENSP000002554654I2D: score=2 STRING: ENSP00000255465
    ZNF16P170201EBI-6509505,EBI-3921553
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0043065positive regulation of apoptotic process ----
    GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA--
    GO:2001235positive regulation of apoptotic signaling pathway IEA--

    Find genes that share ontologies with INCA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INCA1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for INCA1 gene (4 alternative transcripts): 
    NM_001167985.1  NM_001167986.1  NM_001167987.1  NM_213726.2  

    Unigene Cluster for INCA1:

    Inhibitor of CDK, cyclin A1 interacting protein 1
    Hs.658926  [show with all ESTs]
    Unigene Representative Sequence: NM_001167986
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355025(uc002gal.3) ENST00000575780(uc002gam.3) ENST00000576820
    ENST00000574617 ENST00000396829(uc002gaj.3 uc002gak.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat INCA1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate INCA1
    SwitchGear 3'UTR luciferase reporter plasmidINCA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for INCA1
    Predesigned siRNA for gene silencing in human, mouse, rat INCA1
    Clone
    Products:
         
    OriGene clones in human, mouse for INCA1 (see all 19)
    OriGene ORF clones in mouse, rat for INCA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): INCA1 (NM_213726)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INCA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INCA1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for INCA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INCA1
      QuantiTect SYBR Green Assays in human, mouse, rat INCA1
      QuantiFast Probe-based Assays in human, mouse, rat INCA1

    Additional mRNA sequence: 

    AY604176.1 BC119781.1 BC122873.1 

    4 DOTS entries:

    DT.102824452  DT.121003021  DT.40109241  DT.75184825 

    7 AceView cDNA sequences:

    AY601907 AY604176 AY601906 NM_213726 AI904086 BU537690 BF884285 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for INCA1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:              -                                       
    SP2:                                                      


    ECgene alternative splicing isoforms for INCA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    INCA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    INCA1 Expression
    About this image


    INCA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             XX Germ Cells Ovigerous Cord
             Ovigerous Cord
     
     Gonad
             XX Germ Cells Ovigerous Cord
    INCA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INCA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658926

    UniProtKB/Swiss-Prot: INCA1_HUMAN, Q0VD86
    Tissue specificity: Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors

        Custom PCR Arrays for INCA1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for INCA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INCA1
    QuantiTect SYBR Green Assays in human, mouse, rat INCA1
    QuantiFast Probe-based Assays in human, mouse, rat INCA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INCA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for INCA1 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inca11 , 5 inhibitor of CDK, cyclin A1 interacting protein 11, 5 76.19(n)1
    62.34(a)1
      11 (43.21 cM)5
    1038441  NM_001252482.11  NP_001239411.11 
     706883615 


    ENSEMBL Gene Tree for INCA1 (if available)
    TreeFam Gene Tree for INCA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for INCA1 (see all 134)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1149339011,2
    C,F--4893206(+) TGCTGC/TTCCTC 8 E syn12Minor allele frequency- T:0.00WA NA 4670
    rs1932316081,2
    C--4893260(+) CAGAGG/AGGACA 4 -- int11Minor allele frequency- A:0.00EU 1309
    rs1133981741,2
    C--4893270(+) ATGTCA/CATCCA 4 -- int10--------
    rs1444571181,2
    C--4893274(+) CCATCC/TATATT 4 -- int10--------
    rs1834637971,2
    --4893311(+) CCTTTC/GTGTCA 4 -- int10--------
    rs4277031,2
    C,F,A,H--4893357(+) TAACCC/GCAGAC 4 -- int115Minor allele frequency- G:0.43MN NA WA CSA EA 746
    rs798317371,2
    C,F--4893461(+) TGATTA/GAGGTT 8 L syn14Minor allele frequency- G:0.02WA EA NA EU 6109
    rs1469228111,2
    C--4893464(+) TTAAGG/CTTCTT 8 /N /K mis11Minor allele frequency- C:0.00NA 4552
    rs2014671241,2
    --4893488(+) CCATAA/CCGCTG 8 R syn10--------
    rs2009140541,2
    --4893489(+) CATAAC/TGCTGG 8 H R mis10--------

    HapMap Linkage Disequilibrium report for INCA1 (4891425 - 4900905 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for INCA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv907620CNV Loss21882294
    nsv833350CNV Loss17160897
    nsv833349CNV Loss17160897
    nsv907619CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INCA1
    DNA2.0 Custom Variant and Variant Library Synthesis for INCA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for INCA1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with INCA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PubMed id 15159402)1, 2, 3 Diederichs S.... Mueller-Tidow C. (J. Biol. Chem. 2004)
    2. A novel testis protein, RSB-66, interacting with INCA1 (inhibitor of Cdk interacting with cyclin A1). (PubMed id 18756329)1, 3, 9 Chen X....Wang L. (Biochem. Cell Biol. 2008)
    3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    4. The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects. (PubMed id 21750715)1 Zhang F....MA1ller-Tidow C. (PLoS ONE 2011)
    5. Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. (PubMed id 21540187)1 BAoumer N....MA1ller-Tidow C. (J. Biol. Chem. 2011)
    6. Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1. (PubMed id 21874239)2 Li X.B....Zhang J.W. (Mol Med Rep 2011)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    8. Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site. (PubMed id 16148011)1 Kang S....Hogan P.G. (J. Biol. Chem. 2005)
    9. Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development. (PubMed id 15800920)1 Diederichs S....MA1ller-Tidow C. (Int. J. Cancer 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 388324 HGNC: 32224 AceView: INCA1 Ensembl:ENSG00000196388 euGenes: HUgn388324
    ECgene: INCA1 H-InvDB: INCA1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for INCA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for INCA1 gene:
    Search GeneIP for patents involving INCA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for INCA1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for INCA1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for INCA1  
     OriGene qSTAR qPCR primer pairs in human, mouse for INCA1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for INCA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for INCA1   OriGene Custom Protein Services for INCA1  

     
     
     Block miRNA regulation of human, mouse, rat INCA1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing INCA1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INCA1 Predesigned siRNA for gene silencing in human, mouse, rat INCA1
     QuantiFast Probe-based Assays in human, mouse, rat INCA1 QuantiTect SYBR Green Assays in human, mouse, rat INCA1
     Custom PCR Arrays for INCA1 Search Chromatin IP Primers for INCA1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INCA1  Search GeneGlobe Interaction Network for INCA1
     Regulatory tfbs in INCA1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for INCA1 GenScript cDNA clones with any tag delivered in your preferred vector for INCA1
     GenScript Custom Assay Services for INCA1 GenScript Custom overexpressing Cell Line Services for INCA1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for INCA1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for INCA1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     INCA1 antibodies
     INCA1 lysates
     Search for Antibodies for INCA1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for INCA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for INCA1
     Antibodies for INCA1
     ELISAs for INCA1
     CLIAs for INCA1



     Browse ESI BIO Cell Lines and PureStem Progenitors for INCA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INCA1
     SwitchGear 3'UTR luciferase reporter plasmids for INCA1
     SwitchGear Promoter luciferase reporter plasmids for INCA1
     Search ThermoFisher Antibodies for INCA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INCA1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INCA1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INCA1
     LSBio Antibodies in human, mouse, rat for INCA1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for INCA1
      Search eBioscience for proteins for INCA1
      Search eBioscience for elisas for INCA1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      INCA1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4