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Aliases for INCA1 Gene

Aliases for INCA1 Gene

  • Inhibitor Of CDK, Cyclin A1 Interacting Protein 1 2 3
  • Inhibitor Of CDK Interacting With Cyclin A1 4
  • Protein INCA1 3
  • HSD45 3

External Ids for INCA1 Gene

Previous GeneCards Identifiers for INCA1 Gene

  • GC17M005091
  • GC17M004832
  • GC17M004891

Summaries for INCA1 Gene

GeneCards Summary for INCA1 Gene

INCA1 (Inhibitor Of CDK, Cyclin A1 Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include cyclin binding and cyclin-dependent protein serine/threonine kinase inhibitor activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INCA1 Gene

Genomics for INCA1 Gene

Regulatory Elements for INCA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for INCA1 Gene

Start:
4,988,130 bp from pter
End:
4,997,919 bp from pter
Size:
9,790 bases
Orientation:
Minus strand

Genomic View for INCA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INCA1 Gene

Proteins for INCA1 Gene

  • Protein details for INCA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VD86-INCA1_HUMAN
    Recommended name:
    Protein INCA1
    Protein Accession:
    Q0VD86
    Secondary Accessions:
    • Q6J273
    • Q6PKN9

    Protein attributes for INCA1 Gene

    Size:
    236 amino acids
    Molecular mass:
    26817 Da
    Quaternary structure:
    • Interacts with CCNA1. Identified in a complex with CCNA1 and CDK2. Interacts with ZNF16; the interaction inhibits INCA1 activity and induces the cell cycle process.

    Alternative splice isoforms for INCA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INCA1 Gene

Proteomics data for INCA1 Gene at MOPED

Post-translational modifications for INCA1 Gene

  • Phosphorylated when part of a complex with CCNA1 and CDK2. Strongly phosphorylated by CDK2 on its C-terminal region spanning amino acid 149-221. Less intensively phosphorylated by CDK2 on its first 75 amino acid residues.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INCA1 Gene

No data available for DME Specific Peptides for INCA1 Gene

Domains for INCA1 Gene

Protein Domains for INCA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INCA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0VD86

UniProtKB/Swiss-Prot:

INCA1_HUMAN :
  • Q0VD86
Family:
  • Belongs to the INCA family.
genes like me logo Genes that share domains with INCA1: view

No data available for Gene Families for INCA1 Gene

Function for INCA1 Gene

Gene Ontology (GO) - Molecular Function for INCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IDA 21540187
GO:0005515 protein binding IPI 21874239
GO:0030332 cyclin binding IDA 21540187
genes like me logo Genes that share ontologies with INCA1: view
genes like me logo Genes that share phenotypes with INCA1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for INCA1 Gene

Localization for INCA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INCA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INCA1 Gene COMPARTMENTS Subcellular localization image for INCA1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for INCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with INCA1: view

Pathways for INCA1 Gene

SuperPathways for INCA1 Gene

No Data Available

Interacting Proteins for INCA1 Gene

Gene Ontology (GO) - Biological Process for INCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IEA --
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA 21540187
GO:2001235 positive regulation of apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with INCA1: view

No data available for Pathways by source for INCA1 Gene

Transcripts for INCA1 Gene

mRNA/cDNA for INCA1 Gene

(13) REFSEQ mRNAs :
(7) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INCA1 Gene

Inhibitor of CDK, cyclin A1 interacting protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INCA1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for INCA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INCA1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for INCA1 Gene

GeneLoc Exon Structure for
INCA1
ECgene alternative splicing isoforms for
INCA1

Expression for INCA1 Gene

mRNA expression in normal human tissues for INCA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INCA1 Gene

This gene is overexpressed in Testis (11.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for INCA1 Gene

SOURCE GeneReport for Unigene cluster for INCA1 Gene Hs.658926

mRNA Expression by UniProt/SwissProt for INCA1 Gene

Q0VD86-INCA1_HUMAN
Tissue specificity: Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors.
genes like me logo Genes that share expressions with INCA1: view

In Situ Assay Products

Orthologs for INCA1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for INCA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INCA1 35
  • 99.28 (n)
  • 98.37 (a)
INCA1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INCA1 35
  • 81.62 (n)
  • 73.5 (a)
INCA1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INCA1 35
  • 75.23 (n)
  • 62.16 (a)
INCA1 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inca1 35
  • 76.19 (n)
  • 62.34 (a)
Inca1 16
Inca1 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inca1 35
  • 77.12 (n)
  • 66.36 (a)
Species with no ortholog for INCA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INCA1 Gene

ENSEMBL:
Gene Tree for INCA1 (if available)
TreeFam:
Gene Tree for INCA1 (if available)

Paralogs for INCA1 Gene

No data available for Paralogs for INCA1 Gene

Variants for INCA1 Gene

Sequence variations from dbSNP and Humsavar for INCA1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs238225 -- 4,992,750(+) tgttg(C/T)ccagg intron-variant
rs238226 -- 4,993,171(+) cacca(C/T)gcctg intron-variant
rs238227 -- 4,993,544(+) gctca(C/T)tgcaa intron-variant
rs427703 -- 4,990,062(+) TAACC(C/G)CAGAC intron-variant
rs471064 -- 4,995,238(+) GGACT(A/G)TTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INCA1 Gene

Variant ID Type Subtype PubMed ID
nsv833349 CNV Loss 17160897
nsv907619 CNV Loss 21882294
nsv907620 CNV Loss 21882294
nsv833350 CNV Loss 17160897

Relevant External Links for INCA1 Gene

HapMap Linkage Disequilibrium report
INCA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INCA1 Gene

Disorders for INCA1 Gene

No disorders were found for INCA1 Gene.

No data available for UniProtKB/Swiss-Prot for INCA1 Gene

Publications for INCA1 Gene

  1. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PMID: 15159402) Diederichs S. … Mueller-Tidow C. (J. Biol. Chem. 2004) 2 3 4
  2. A novel testis protein, RSB-66, interacting with INCA1 (inhibitor of Cdk interacting with cyclin A1). (PMID: 18756329) Chen X. … Wang L. (Biochem. Cell Biol. 2008) 2 3 23
  3. Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1. (PMID: 21874239) Li X.B. … Zhang J.W. (Mol Med Rep 2011) 3 4
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3

Products for INCA1 Gene

Sources for INCA1 Gene

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