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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INCA1 Gene

protein-coding   GIFtS: 43
GCID: GC17M004891

inhibitor of CDK, cyclin A1 interacting protein 1

 Explore 1 disease affiliated with
INCA1 via our new
 Human Malady Compendium 
Biological research products
for INCA1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Inhibitor Of CDK, Cyclin A1 Interacting Protein 11 2
Protein INCA12
Inhibitor Of CDK Interacting With Cyclin A13

External Ids:    HGNC: 322241   Entrez Gene: 3883242   Ensembl: ENSG000001963887   UniProtKB: Q0VD863   

Export aliases for INCA1 gene to outside databases

Previous GC identifers: GC17M005091 GC17M004832


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INCA1 gene promoter:
         E2F-4   E2F-3a   E2F-5   SREBP-1c   E2F-2   Nkx2-5   SREBP-1b   E2F   SREBP-1a   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINCA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for INCA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INCA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.2

INCA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INCA1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M004891:  view genomic region     (about GC identifiers)

Start:
4,891,425 bp from pter      End:
4,900,905 bp from pter
Size:
9,481 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: INCA1_HUMAN, Q0VD86 (See protein sequence)
Recommended Name: Protein INCA1  
Size: 236 amino acids; 26817 Da
Subunit: Interacts with CCNA1. Identified in a complex with CCNA1 and CDK2
Subcellular location: Nucleus
Secondary accessions: Q6J273 Q6PKN9
Alternative splicing: 2 isoforms:  Q0VD86-1   Q0VD86-2   

Explore the universe of human proteins at neXtProt for INCA1: NX_Q0VD86

Post-translational modifications:

  • Phosphorylated when part of a complex with CCNA1 and CDK2. Strongly phosphorylated by CDK2 on its C-terminal region
  • spanning amino acid 149-221. Less intensively phosphorylated by CDK2 on its first 75 amino acid residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q0VD86

  • INCA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001161457.1  NP_001161458.1  NP_001161459.1  NP_998891.2  

    ENSEMBL proteins: 
     ENSP00000347129   ENSP00000461844   ENSP00000460673   ENSP00000458316   ENSP00000380041  

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    Uscn Proteins for INCA1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    INCA1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    INCA1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026238 INCA1

    Graphical View of Domain Structure for InterPro Entry Q0VD86

    ProtoNet protein and cluster: Q0VD86

    UniProtKB/Swiss-Prot: INCA1_HUMAN, Q0VD86
    Similarity: Belongs to the INCA family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INCA1
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    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004861cyclin-dependent protein kinase inhibitor activity IDA--
    GO:0030332cyclin binding IDA--


    INCA1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for INCA1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Inca1):
     cellular  hematopoietic system  immune system 

    INCA1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INCA1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for INCA1 (Q0VD863 ENSP000003471294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK2P249413, ENSP000002669704I2D: score=1 STRING: ENSP00000266970
    CCNA1P783963, ENSP000002554654I2D: score=2 STRING: ENSP00000255465
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045736negative regulation of cyclin-dependent protein kinase activity IDA--


    INCA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INCA1
    Search CenterWatch for drugs/clinical trials and news about INCA1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INCA1 gene (4 alternative transcripts): 
    NM_001167985.1  NM_001167986.1  NM_001167987.1  NM_213726.2  

    Unigene Cluster for INCA1:

    Inhibitor of CDK, cyclin A1 interacting protein 1
    Hs.658926  [show with all ESTs]
    Unigene Representative Sequence: NM_001167986
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355025(uc002gal.3) ENST00000575780(uc002gam.3) ENST00000576820
    ENST00000574617 ENST00000396829(uc002gaj.3 uc002gak.3)

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    Inhib. RNA
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    OriGene siRNA: INCA1
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INCA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INCA1

    Additional cDNA sequence: 

    AY604176.1 BC119781.1 BC122873.1 

    4 DOTS entries:

    DT.102824452  DT.121003021  DT.40109241  DT.75184825 

    7 AceView cDNA sequences:

    AY601907 AY604176 AY601906 NM_213726 AI904086 BU537690 BF884285 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for INCA1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:              -                                       
    SP2:                                                      


    ECgene alternative splicing isoforms for INCA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INCA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    INCA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryOvigerous CordXX Germ CellsFemale Gametocytes, Germ Cells
    OvaryOvigerous CordOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See INCA1 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.658926

    UniProtKB/Swiss-Prot: INCA1_HUMAN, Q0VD86
    Tissue specificity: Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INCA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for INCA1 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inca11 , 5 inhibitor of CDK, cyclin A1 interacting protein 11, 5 76.19(n)1
    62.34(a)1
      11 (43.21 cM)5
    1038441  NM_213729.11  NP_998894.11 
     706883615 


    ENSEMBL Gene Tree for INCA1 (if available)
    TreeFam Gene Tree for INCA1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/116 NCBI SNPs in INCA1 are shown (see all 116    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421579531,2
    C--4893203(+) ATGTGC/GTGCTC 8 H Q mis11Minor allele frequency- G:0.00NA 4552
    rs1149339011,2
    C,F,--4893206(+) TGCTGC/TTCCTC 8 E syn12Minor allele frequency- T:0.00WA NA 4670
    rs1932316081,2
    C,--4893260(+) CAGAGG/AGGACA 4 -- int11Minor allele frequency- A:0.00EU 1309
    rs1444571181,2
    C,--4893274(+) CCATCC/TATATT 4 -- int10--------
    rs1834637971,2
    --4893311(+) CCTTTC/GTGTCA 4 -- int10--------
    rs4277031,2
    C,F,A,H,--4893357(+) TAACCC/GCAGAC 4 -- int115Minor allele frequency- G:0.43MN NA WA CSA EA 746
    rs798317371,2
    C,F,--4893461(+) TGATTA/GAGGTT 8 L syn14Minor allele frequency- G:0.02WA EA NA EU 6109
    rs1469228111,2
    C--4893464(+) TTAAGG/CTTCTT 8 /N /K mis11Minor allele frequency- C:0.00NA 4552
    rs2014671241,2
    --4893488(+) CCATAA/CCGCTG 8 R syn10--------
    rs2009140541,2
    --4893489(+) CATAAC/TGCTGG 8 H R mis10--------

    HapMap Linkage Disequilibrium report for INCA1 (4891425 - 4900905 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for INCA1
         1 CNV: 4987

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    INCA1 for disorders           About GeneDecksing

    1 disease for INCA1:    About MalaCards
    testicular cancer


    Export disorders for INCA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INCA1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with INCA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PubMed id 15159402)1, 2, 3 Diederichs S.... Mueller-Tidow C. (2004)
    2. A novel testis protein, RSB-66, interacting with INCA 1 (inhibitor of Cdk interacting with cyclin A1). (PubMed id 18756329)1, 3, 9 Chen X....Wang L. (2008)
    3. The inhibitor of growth protein 5 (ING5) depends on I NCA1 as a co-factor for its antiproliferative effects. (PubMed id 21750715)1 Zhang F....MA1ller-Tidow C. (2011)
    4. Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic si gnaling. (PubMed id 21540187)1 Baumer N....Muller-Tidow C. (2011)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    6. Inhibition of the calcineurin-NFAT interaction by sma ll organic molecules reflects binding at an allosteric site. (PubMed id 16148011)1 Kang S....Hogan P.G. (2005)
    7. Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development. (PubMed id 15800920)1 Diederichs S....Muller-Tidow C. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388324 HGNC: 32224 AceView: INCA1 Ensembl:ENSG00000196388 euGenes: HUgn388324
    ECgene: INCA1 H-InvDB: INCA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INCA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INCA1 gene:
    Search GeneIP for patents involving INCA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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