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Aliases for INAVA Gene

Aliases for INAVA Gene

  • Innate Immunity Activator 2
  • Chromosome 1 Open Reading Frame 106 2 3 5
  • C1orf106 3 4 5
  • Uncharacterized Protein C1orf106 3

External Ids for INAVA Gene

Previous HGNC Symbols for INAVA Gene

  • C1orf106

Summaries for INAVA Gene

GeneCards Summary for INAVA Gene

INAVA (Innate Immunity Activator) is a Protein Coding gene. An important paralog of this gene is FRMD4A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INAVA Gene

Genomics for INAVA Gene

Regulatory Elements for INAVA Gene

Enhancers for INAVA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G200890 2 FANTOM5 Ensembl ENCODE dbSUPER 13.6 +4.6 4588 10.0 HDGF FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF143 ZNF207 INAVA MROH3P ENSG00000234132 CSRP1 IGFN1 TMEM9 GC01M200900
GH01G200915 1.2 ENCODE dbSUPER 11.4 +25.8 25812 1.9 PKNOX1 TCF12 ZNF766 CAVIN1 MIER2 REST TBX21 ZNF592 MEF2D CREB3 MROH3P INAVA GPR25 ENSG00000234132 GC01M200933
GH01G200861 1.1 ENCODE dbSUPER 11.4 -28.1 -28149 2.2 HDGF PKNOX1 MXI1 ARNT MAX EBF1 ZIC2 ZBTB40 RELA ZNF121 INAVA CAMSAP2 LOC101929224 RPL34P6 GC01M200787
GH01G200780 1 Ensembl ENCODE 10.3 -110.2 -110248 0.8 MXI1 ZNF384 ZNF2 ZNF316 PRDM10 RELB IKZF2 MAFK ZNF362 MTA2 CAMSAP2 INAVA GPR25 GC01M200787 PIR37471
GH01G200970 0.9 ENCODE 11.2 +79.1 79140 0.1 HDGF PKNOX1 TBL1XR1 WRNIP1 BMI1 RAD21 ZNF143 ZNF207 RELB IKZF2 ENSG00000234132 ENSG00000229191 KIF21B INAVA PIR41355 GC01P200949
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INAVA on UCSC Golden Path with GeneCards custom track

Promoters for INAVA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000018007 452 1401 ZFP64 SIN3A ZNF48 ZNF121 ELK1 ZNF143 ZNF207 ZNF263 SP5 PPARG

Genomic Location for INAVA Gene

Chromosome:
1
Start:
200,891,048 bp from pter
End:
200,915,736 bp from pter
Size:
24,689 bases
Orientation:
Plus strand

Genomic View for INAVA Gene

Genes around INAVA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INAVA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INAVA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INAVA Gene

Proteins for INAVA Gene

  • Protein details for INAVA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KP66-CA106_HUMAN
    Recommended name:
    Uncharacterized protein C1orf106
    Protein Accession:
    Q3KP66
    Secondary Accessions:
    • B4E1K9
    • E9PFY0
    • Q9NV65
    • Q9NVI0

    Protein attributes for INAVA Gene

    Size:
    663 amino acids
    Molecular mass:
    72914 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91771.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for INAVA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INAVA Gene

Post-translational modifications for INAVA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INAVA Gene

No data available for DME Specific Peptides for INAVA Gene

Domains & Families for INAVA Gene

Protein Domains for INAVA Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with INAVA: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for INAVA Gene

Function for INAVA Gene

Phenotypes for INAVA Gene

genes like me logo Genes that share phenotypes with INAVA: view

Animal Models for INAVA Gene

MGI Knock Outs for INAVA:

Animal Model Products

miRNA for INAVA Gene

miRTarBase miRNAs that target INAVA

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INAVA Gene

Localization for INAVA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INAVA gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for INAVA Gene

Pathways & Interactions for INAVA Gene

SuperPathways for INAVA Gene

No Data Available

Interacting Proteins for INAVA Gene

Gene Ontology (GO) - Biological Process for INAVA Gene

None

No data available for Pathways by source and SIGNOR curated interactions for INAVA Gene

Drugs & Compounds for INAVA Gene

No Compound Related Data Available

Transcripts for INAVA Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INAVA Gene

No ASD Table

Relevant External Links for INAVA Gene

GeneLoc Exon Structure for
INAVA
ECgene alternative splicing isoforms for
INAVA

Expression for INAVA Gene

NURSA nuclear receptor signaling pathways regulating expression of INAVA Gene:

INAVA
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for INAVA Gene

Orthologs for INAVA Gene

This gene was present in the common ancestor of animals.

Orthologs for INAVA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf106 35
  • 99 (a)
OneToOne
C1H1orf106 34
  • 96.8 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 85 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 5730559C18Rik 16 35 34
  • 84.54 (n)
rat
(Rattus norvegicus)
Mammalia RGD1311892 34
  • 84.44 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf106 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf106 35
  • 72 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1orf106 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1ORF106 34
  • 63.56 (n)
C1orf106 35
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf106 35
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-163l21.4 34
  • 62.32 (n)
C8H1orf106 (2 of 2) 35
  • 36 (a)
OneToMany
C11H1orf106 (1 of 2) 35
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F07C6.4 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 8 (a)
OneToMany
Species where no ortholog for INAVA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for INAVA Gene

ENSEMBL:
Gene Tree for INAVA (if available)
TreeFam:
Gene Tree for INAVA (if available)

Paralogs for INAVA Gene

Paralogs for INAVA Gene

Pseudogenes.org Pseudogenes for INAVA Gene

genes like me logo Genes that share paralogs with INAVA: view

Variants for INAVA Gene

Sequence variations from dbSNP and Humsavar for INAVA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000059611 -- 200,894,242(+) TGCCT(C/G)TCAGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000243829 -- 200,897,374(+) TTGAA(A/G)GTTGT intron-variant
rs1000307818 -- 200,897,559(+) GGCGT(A/G)GGACA intron-variant
rs1000326230 -- 200,905,429(+) CACCT(A/G)TAGTC intron-variant
rs1000336809 -- 200,899,269(+) GAGTT(A/G)TAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INAVA Gene

Variant ID Type Subtype PubMed ID
esv2721362 CNV deletion 23290073
esv2721373 CNV deletion 23290073
esv2721384 CNV deletion 23290073
esv33174 CNV loss 17666407
esv3588563 CNV gain 21293372
nsv1012562 CNV gain 25217958
nsv1133931 CNV deletion 24896259
nsv548991 CNV gain 21841781
nsv946574 CNV duplication 23825009

Variation tolerance for INAVA Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.61; 72.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INAVA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INAVA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INAVA Gene

Disorders for INAVA Gene

Relevant External Links for INAVA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INAVA

No disorders were found for INAVA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INAVA Gene

Publications for INAVA Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes. (PMID: 28436939) Yan J. … Abraham C. (J. Clin. Invest. 2017) 2 64
  4. Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis. (PMID: 27980695) Zhou F. … Zhang X. (Clin Epigenetics 2016) 3 64
  5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. (PMID: 25468996) Guo Z. … Zaidel-Bar R. (Sci Signal 2014) 3 64

Products for INAVA Gene

Sources for INAVA Gene

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