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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INADL Gene

protein-coding   GIFtS: 54
GCID: GC01P062208

InaD-like (Drosophila)

 Explore 10 diseases affiliated with
INADL via our new
 Human Malady Compendium 
Biological research products
for INADL
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
InaD-Like (Drosophila)1 2     InaD-Like1
PATJ1 2 3 5     Channel-Interacting PDZ Domain Protein2
Cipp1 2     Inactivation No After-Potential D-Like Protein2
Pals1-Associated Tight Junction Protein2 3     InaD-Like Protein2
Protein Associated To Tight Junctions2 3     PDZ Domain Protein2
HINADL1     Inadl Protein3

External Ids:    HGNC: 288811   Entrez Gene: 102072   Ensembl: ENSG000001328497   OMIM: 6031995   UniProtKB: Q8NI353   

Export aliases for INADL gene to outside databases

Previous GC identifers: GC01P062141 GC01P061131 GC01P061565 GC01P061578 GC01P061920 GC01P060320


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INADL:
This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins
with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight
junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein
which tethers several members of a multimeric signaling complex in photoreceptors. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: INADL_HUMAN, Q8NI35
Function: Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May
regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or
function of ASIC3 in sensory neurons

Gene Wiki entry for INADL


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INADL gene promoter:
         LHX3b/Lhx3b   Elk-1   Nkx2-2   GATA-1   CREB   IRF-2   Pax-3   GATA-6   LHX3a/Lhx3a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINADL promoter sequence
   Search SABiosciences Chromatin IP Primers for INADL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INADL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31

INADL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INADL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P062208:  view genomic region     (about GC identifiers)

Start:
62,208,149 bp from pter      End:
62,629,592 bp from pter
Size:
421,444 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: INADL_HUMAN, Q8NI35 (See protein sequence)
Recommended Name: InaD-like protein  
Size: 1801 amino acids; 196368 Da
Subunit: Interacts with ASIC3, KCNJ10, KCNJ15, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NLGN2, MPP7, HTR2A and SLC6A4 (By
similarity). Forms a ternary complex with MPP5, CRB1 and CRB3. Interacts with TJP3/ZO-3 and CLDN1/claudin-1. Component
of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Directly interacts with
HTR4 (By similarity). Interacts (via PDZ domain 8) with WWC1 (via the ADDV motif)
Subcellular location: Membrane. Cell junction, tight junction. Apical cell membrane. Cytoplasm, perinuclear region.
Note=Localized in the paranodal region of myelinating Schwann cells (By similarity). Membrane-associated. Localizes to
tight junctions in epithelial cells. Also found at the apical plasma membrane
Sequence caution: Sequence=CAH70416.1; Type=Erroneous gene model prediction; Sequence=CAI21733.1; Type=Erroneous gene
model prediction; Sequence=CAI22258.1; Type=Erroneous gene model prediction;
6/8 PDB 3D structures from and Proteopedia for INADL (see all 8):
1VF6 (3D)        2D92 (3D)        2DAZ (3D)        2DB5 (3D)        2DLU (3D)        2DM8 (3D)    
Secondary accessions: O15249 O43742 O60833 Q5VUA5 Q5VUA6 Q5VUA7 Q5VUA8 Q5VUA9 Q5VUB0 Q8WU78 Q9H3N9
Alternative splicing: 5 isoforms:  Q8NI35-1   Q8NI35-2   Q8NI35-3   Q8NI35-4   Q8NI35-5   

Explore the universe of human proteins at neXtProt for INADL: NX_Q8NI35

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NI35

  • INADL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_795352.2  
    ENSEMBL proteins: 
     ENSP00000360200   ENSP00000326199   ENSP00000433669   ENSP00000307496   ENSP00000445790  
     ENSP00000440094  
    Reactome Protein details: Q8NI35
    Human Recombinant Protein Products: 
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    Uscn Proteins for INADL

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane TAS--
    GO:0005923tight junction IDA--
    GO:0016324apical plasma membrane IEA--
    GO:0045177apical part of cell ----


    INADL for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    INADL for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001478 PDZ
     IPR004172 L27
     IPR015132 L27_2

    Graphical View of Domain Structure for InterPro Entry Q8NI35

    ProtoNet protein and cluster: Q8NI35

    1 Blocks protein family: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: INADL_HUMAN, Q8NI35
    Domain: The L27 domain (also called Maguk recruitment domain) is required for interaction with MPP5 and CRB3, and MPP5
    localization to tight junctions
    Domain: The PDZ domain 6 mediates interaction with the C-terminus of TJP3 and is crucial for localization to the tight
    junctions. The PDZ domain 8 interacts with CLDN1 but is not required for proper localization
    Similarity: Contains 1 L27 domain
    Similarity: Contains 10 PDZ (DHR) domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: INADL_HUMAN, Q8NI35
    Function: Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May
    regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or
    function of ASIC3 in sensory neurons

    miRNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    INADL for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    Cell-cell junction organization1.00
    Tight junction interactions0.49
    Cell junction organization0.69
    Cell-Cell communication0.45
    2Tight junction
    Tight junction1.00
    3Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for INADL
        Epithelial Tight Junctions

    4        Reactome Pathways for INADL
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    1         Kegg Pathway  (Kegg details for INADL):
        Tight junction


    INADL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INADL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for INADL (Q8NI351, 2, 3 ENSP000003602004) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX18Q9NVP12, 3, ENSP000002632394MINT-65643 I2D: score=3 STRING: ENSP00000263239
    MPP5Q8N3R92, 3, ENSP000002616814MINT-1774417 MINT-1774200 MINT-2843240 I2D: score=2 STRING: ENSP00000261681
    TJP3O950492, 3, ENSP000002629684MINT-58720 MINT-58722 MINT-58721 I2D: score=2 STRING: ENSP00000262968
    CRB1P822792, 3, ENSP000003563704MINT-1774293 MINT-1774377 I2D: score=1 STRING: ENSP00000356370
    F2RL2O002542, 3, ENSP000002966414MINT-4300898 MINT-4300885 I2D: score=1 STRING: ENSP00000296641
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034329cell junction assembly TAS--
    GO:0035556intracellular signal transduction NAS9280290
    GO:0045216cell-cell junction organization TAS--
    GO:0070830tight junction assembly TAS--


    INADL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INADL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INADL
    6 Novoseek chemical compound relationships for INADL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 30.5 7 9647694 (2), 18615145 (1), 12853458 (1), 18923045 (1)
    tyrosine 25.5 4 19138174 (1), 11983165 (1)
    glutamate 20.3 1 9647694 (1)
    calcium 0 7 12765677 (1), 12716953 (1), 14718565 (1), 17409629 (1)
    potassium 0 1 16878697 (1)
    dopamine 0 1 15295038 (1)

    Search CenterWatch for drugs/clinical trials and news about INADL 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INADL gene (3 alternative transcripts): 
    NM_176877.2  NM_005799.2  NM_176878.1  

    Unigene Cluster for INADL:

    InaD-like (Drosophila)
    Hs.478125  [show with all ESTs]
    Unigene Representative Sequence: NM_176877
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371158(uc001dab.3 uc009wag.3) ENST00000484562(uc001dad.3)
    ENST00000316485(uc009waf.1) ENST00000459752(uc001daa.2 uc010oou.1)
    ENST00000484937(uc001dac.3) ENST00000488913 ENST00000493967 ENST00000494842
    ENST00000490547 ENST00000307297 ENST00000465798 ENST00000472512 ENST00000543708(uc010oot.2)
    ENST00000545929

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    hsa-miR-21* hsa-miR-579 hsa-miR-4307 hsa-miR-642a hsa-miR-330-5p hsa-miR-570 hsa-miR-4325 hsa-miR-155
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF397170.1 AJ001306.1 AJ224747.1 AJ224748.1 AK293519.1 AK294187.1 AK304355.1 AK307713.1 
    AK308428.1 AK308665.1 BC021135.1 BC142661.1 BC142723.1 BC144135.1 

    18 DOTS entries:

    DT.110720  DT.100781932  DT.121419068  DT.97789417  DT.70104727  DT.119248  DT.100721371  DT.97833684 
    DT.121419091  DT.40314090  DT.97789428  DT.75154718  DT.75192209  DT.91674136  DT.91748005  DT.95362168 
    DT.40250926  DT.75189274 

    24/155 AceView cDNA sequences (see all 155):

    AI392921 CD356816 BE392595 AI697184 BQ439979 AW305081 NM_005799 NM_176877 
    AI765784 AA777657 BE501835 BF331554 BU678903 AJ224747 AI601105 BF475257 
    AA843633 AU132556 NM_176878 NM_170605 BE073934 CB047676 AA357999 AJ224748 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for INADL (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47
    SP1:        -                 -                                   -                 -                                                         
    SP2:        -                 -                                                                                                               
    SP3:        -                 -                                   -                                                                           
    SP4:        -                 -                                   -     -                                                                     
    SP5:        -                 -                                   -                 -                                                         


    ECgene alternative splicing isoforms for INADL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INADL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See INADL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INADL

    SOURCE GeneReport for Unigene cluster: Hs.478125

    UniProtKB/Swiss-Prot: INADL_HUMAN, Q8NI35
    Tissue specificity: Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and
    cerebellum in the brain

        SABiosciences Expression via Pathway-Focused PCR Array including INADL: 
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INADL gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves INADL1 InaD-like (Drosophila) 70.9(n)
    69.19(a)
      424682  XM_003641694.1  XP_003641742.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    40(a)
    possible ortholog
    4(100183574-100312687)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480234012   -- 73.88(n)    48023401 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.206032 Transcribed sequence with weak similarity to protein more 78.35(n)    57092330 
    fruit fly
    (Drosophila melanogaster)
    Insecta Patj6
    CG158036
    (see all 3)
    --
    23(a)
    19(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    3L(1798803-1802184)
    3R(14159008-14186699)
    worm
    (Caenorhabditis elegans)
    Secernentea mpz-16
    Multiple PDZ domain protein family member (mpz-1)
    10(a)
    1 → many
    II(10738927-10775002)


    ENSEMBL Gene Tree for INADL (if available)
    TreeFam Gene Tree for INADL (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INADL gene
    PARD3B2  PDZD22  IL162  PARD32  LNX22  MPDZ2  LNX12  
    6 SIMAP similar genes for INADL using alignment to 4 protein entries:     INADL_HUMAN (see all proteins):
    DLG4    TJP2    MPDZ    ARHGAP23    SYNJ2BP    DLG2

    INADL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7635 NCBI SNPs in INADL are shown (see all 7635    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1466890021,2
    --62206252(+) ACAGAA/GCGAGA 1 -- us2k10--------
    rs1122061771,2
    C,--62206281(+) ACAAC-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs11517781,2
    C,--62206358(+) CCAGGT/CAATAA 1 -- us2k1 tfbs38Minor allele frequency- C:0.00NA WA CSA 14
    rs12904411,2
    C,F,A,H,--62206567(+) TCCATC/TTGGCA 1 -- us2k19Minor allele frequency- T:0.15NS EA NA CSA WA 541
    rs11517791,2
    C,F,--62206620(-) TGGTTT/CCTGCT 1 -- us2k15Minor allele frequency- C:0.32NA CSA WA 125
    rs1498761141,2
    --62206644(+) TGTCTA/TCTTAC 1 -- us2k10--------
    rs120749121,2
    C,F,--62206678(+) CTTTTA/CAAACA 1 -- us2k1 tfbs31Minor allele frequency- C:0.06WA 118
    rs1449203951,2
    --62206859(+) CTCCGA/GGCTAA 1 -- us2k10--------
    rs75385471,2
    C,A,--62206968(+) cctccT/Cgggtt 1 -- us2k13Minor allele frequency- C:0.20NA CSA 5
    rs1886732241,2
    --62207068(+) GTTTCA/CTCATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for INADL (62208149 - 62458149 bp, first 250kb of INADL)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 20 variations for INADL
         11 CNVs: 1002 63907 34827 1001 48347 84279 31625 1542 48349 9884 48348
         9 Indels: 11398 97371 97370 44600 42393 60829 39609 63899 24238

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    INADL for disorders           About GeneDecksing

    OMIM gene information: 603199    OMIM disorders: --

    10 diseases for INADL:    About MalaCards
    leber congenital amaurosis    bullous pemphigoid    retinal degeneration    cystic fibrosis
    fibrosis    retinitis    cervical cancer    cervicitis
    pharyngitis    neuronitis

    3 Novoseek disease relationships for INADL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal degeneration 29.1 1 15755798 (1)
    cystic fibrosis 9.81 1 11707463 (1)
    tumors 0 2 19015633 (1)

    Human Genome Epidemiology (HuGE) Navigator: INADL (1 document)

    Export disorders for INADL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INADL gene, integrated from 9 sources (see all 116):
    (articles sorted by number of sources associating them with INADL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of a novel PDZ domain protein with homology to INAD from Drosophila melanogaster. (PubMed id 9280290)1, 2, 3, 9 Philipp S. and Flockerzi V. (1997)
    2. Isolation of novel heart-specific genes using the BodyMap database. (PubMed id 11374908)1, 2, 3 Soejima H.... Mukai T. (2001)
    3. The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. (PubMed id 11927608)1, 2, 9 Roh M.H.... Margolis B. (2002)
    4. KIBRA modulates directional migration of podocytes. (PubMed id 18596123)1, 2 Duning K.... Pavenstaedt H. (2008)
    5. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. (PubMed id 16678097)1, 2 Wells C.D.... Pawson T. (2006)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    7. Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes. (PubMed id 15241471)1, 2 Li Y.... Lavie A. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions. (PubMed id 12021270)1, 2 Roh M.H.... Margolis B. (2002)
    10. hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells. (PubMed id 11964389)1, 2 Lemmers C....Le Bivic A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10207 HGNC: 28881 AceView: INADL Ensembl:ENSG00000132849 euGenes: HUgn10207
    ECgene: INADL Kegg: 10207 H-InvDB: INADL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INADL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INADL gene:
    Search GeneIP for patents involving INADL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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