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INADL Gene

protein-coding   GIFtS: 59
GCID: GC01P062208

InaD-Like (Drosophila)

  Search for INADL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
InaD-Like (Drosophila)1 2     InaD-like2
PATJ2 3 5     Channel-Interacting PDZ Domain Protein2
Pals1-Associated Tight Junction Protein2 3     Inactivation No After-Potential D-Like Protein2
Protein Associated To Tight Junctions2 3     InaD-Like Protein2
hINADL2 3     PDZ Domain Protein2
Cipp2     Inadl Protein3

External Ids:    HGNC: 288811   Entrez Gene: 102072   Ensembl: ENSG000001328497   OMIM: 6031995   UniProtKB: Q8NI353   

Export aliases for INADL gene to outside databases

Previous GC identifers: GC01P062141 GC01P061131 GC01P061565 GC01P061578 GC01P061920 GC01P060320


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INADL Gene:
This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and
proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein
localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a
scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. (provided
by RefSeq, Jul 2008)

GeneCards Summary for INADL Gene:
INADL (InaD-like (Drosophila)) is a protein-coding gene. An important paralog of this gene is PARD3B.

UniProtKB/Swiss-Prot: INADL_HUMAN, Q8NI35
Function: Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May
regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression
and/or function of ASIC3 in sensory neurons

Gene Wiki entry for INADL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INADL gene promoter:
         LHX3b/Lhx3b   Elk-1   Nkx2-2   GATA-1   CREB   IRF-2   Pax-3   GATA-6   LHX3a/Lhx3a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINADL promoter sequence
   Search Chromatin IP Primers for INADL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INADL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31

INADL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INADL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P062208:  view genomic region     (about GC identifiers)

Start:
62,208,149 bp from pter      End:
62,629,592 bp from pter
Size:
421,444 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: INADL_HUMAN, Q8NI35 (See protein sequence)
Recommended Name: InaD-like protein  
Size: 1801 amino acids; 196368 Da
Subunit: Interacts with ASIC3, KCNJ10, KCNJ15, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NLGN2, MPP7, HTR2A and SLC6A4 (By
similarity). Forms a ternary complex with MPP5, CRB1 and CRB3. Interacts with TJP3/ZO-3 and CLDN1/claudin-1.
Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Directly
interacts with HTR4 (By similarity). Interacts (via PDZ domain 8) with WWC1 (via the ADDV motif)
Sequence caution: Sequence=CAH70416.1; Type=Erroneous gene model prediction; Sequence=CAI21733.1; Type=Erroneous
gene model prediction; Sequence=CAI22258.1; Type=Erroneous gene model prediction;
Selected PDB 3D structures from and Proteopedia for INADL (see all 8):
1VF6 (3D)        2D92 (3D)        2DAZ (3D)        2DB5 (3D)        2DLU (3D)        2DM8 (3D)    
Secondary accessions: O15249 O43742 O60833 Q5VUA5 Q5VUA6 Q5VUA7 Q5VUA8 Q5VUA9 Q5VUB0 Q8WU78
Q9H3N9
Alternative splicing: 5 isoforms:  Q8NI35-1   Q8NI35-2   Q8NI35-3   Q8NI35-4   Q8NI35-5   

Explore the universe of human proteins at neXtProt for INADL: NX_Q8NI35

Explore proteomics data for INADL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See INADL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_795352.2  
    ENSEMBL proteins: 
     ENSP00000326199   ENSP00000360200   ENSP00000433669   ENSP00000307496   ENSP00000445790  
     ENSP00000440094  
    Reactome Protein details: Q8NI35

    INADL Human Recombinant Protein Products:

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    Novus Biologicals INADL Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INADL

     
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    Abcam antibodies for INADL (Q8NI35 , Q8NI35)
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    INADL Assay Products:

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    Search eBioscience for ELISAs for INADL 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR015132 L27_2
     IPR001478 PDZ
     IPR004172 L27

    Graphical View of Domain Structure for InterPro Entry Q8NI35

    ProtoNet protein and cluster: Q8NI35

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: INADL_HUMAN, Q8NI35
    Domain: The L27 domain (also called Maguk recruitment domain) is required for interaction with MPP5 and CRB3, and
    MPP5 localization to tight junctions
    Domain: The PDZ domain 6 mediates interaction with the C-terminus of TJP3 and is crucial for localization to the
    tight junctions. The PDZ domain 8 interacts with CLDN1 but is not required for proper localization
    Similarity: Contains 1 L27 domain
    Similarity: Contains 10 PDZ (DHR) domains


    Find genes that share domains with INADL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INADL_HUMAN, Q8NI35
    Function: Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May
    regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression
    and/or function of ASIC3 in sensory neurons

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11927608
         
    Find genes that share ontologies with INADL           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INADL
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INADL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INADL

    miRNA
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    miRTarBase miRNAs that target INADL:
    hsa-mir-15b-5p (MIRT046482), hsa-mir-548b-3p (MIRT040510)

    Block miRNA regulation of human, mouse, rat INADL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INADL (see all 33):
    hsa-miR-21* hsa-miR-579 hsa-miR-4307 hsa-miR-642a hsa-miR-330-5p hsa-miR-570 hsa-miR-4325 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidINADL 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat INADL

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: INADL (NM_176877)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INADL

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INADL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INADL_HUMAN, Q8NI35: Membrane. Cell junction, tight junction. Apical cell membrane. Cytoplasm, perinuclear
    region. Note=Localized in the paranodal region of myelinating Schwann cells (By similarity). Membrane-associated.
    Localizes to tight junctions in epithelial cells. Also found at the apical plasma membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005923tight junction IDA--
    GO:0016324apical plasma membrane IEA--
    GO:0043234protein complex IEA--
    GO:0045177apical part of cell ----

    Find genes that share ontologies with INADL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for INADL About    
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    2Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    3Tight junction
    Tight junction
    4Hippo signaling pathway
    Hippo signaling pathway


    Find genes that share SuperPaths with INADL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for INADL
        Epithelial Tight Junctions

    1 Reactome Pathway for INADL
        Tight junction interactions


    2 Kegg Pathways  (Kegg details for INADL):
        Hippo signaling pathway
    Tight junction

        Pathway & Disease-focused RT2 Profiler PCR Array including INADL: 
              Tight Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for INADL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for INADL (Q8NI351, 2, 3 ENSP000003602004) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX18Q9NVP12, 3, ENSP000002632394MINT-65643 I2D: score=3 STRING: ENSP00000263239
    MPP5Q8N3R91, 2, 3, ENSP000002616814EBI-724390,EBI-2513978 MINT-1774417 MINT-1774200 MINT-2843240 I2D: score=2 STRING: ENSP00000261681
    CRB1P822791, 2, 3, ENSP000003563704EBI-724390,EBI-1048648 MINT-1774293 MINT-1774377 I2D: score=1 STRING: ENSP00000356370
    TJP3O950492, 3, ENSP000002629684MINT-58720 MINT-58722 MINT-58721 I2D: score=2 STRING: ENSP00000262968
    F2RL2O002542, 3, ENSP000002966414MINT-4300898 MINT-4300885 I2D: score=1 STRING: ENSP00000296641
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034329cell junction assembly TAS--
    GO:0035556intracellular signal transduction NAS9280290
    GO:0045216cell-cell junction organization TAS--
    GO:0070830tight junction assembly TAS--

    Find genes that share ontologies with INADL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INADL

    6 Novoseek inferred chemical compound relationships for INADL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 30.5 7 9647694 (2), 18615145 (1), 12853458 (1), 18923045 (1)
    tyrosine 25.5 4 19138174 (1), 11983165 (1)
    glutamate 20.3 1 9647694 (1)
    calcium 0 7 12765677 (1), 12716953 (1), 14718565 (1), 17409629 (1)
    potassium 0 1 16878697 (1)
    dopamine 0 1 15295038 (1)



    Find genes that share compounds with INADL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for INADL gene (3 alternative transcripts): 
    NM_176877.2  NM_005799.2  NM_176878.1  

    Unigene Cluster for INADL:

    InaD-like (Drosophila)
    Hs.478125  [show with all ESTs]
    Unigene Representative Sequence: NM_176877
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316485(uc009waf.1) ENST00000459752(uc001daa.2 uc010oou.1)
    ENST00000484562(uc001dad.3) ENST00000371158(uc001dab.3 uc009wag.3)
    ENST00000484937(uc001dac.3) ENST00000488913 ENST00000493967 ENST00000494842
    ENST00000490547 ENST00000307297 ENST00000465798 ENST00000472512 ENST00000543708(uc010oot.2)
    ENST00000545929
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate INADL (see all 33):
    hsa-miR-21* hsa-miR-579 hsa-miR-4307 hsa-miR-642a hsa-miR-330-5p hsa-miR-570 hsa-miR-4325 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidINADL 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INADL (NM_176877)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INADL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INADL
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INADL
      QuantiTect SYBR Green Assays in human, mouse, rat INADL
      QuantiFast Probe-based Assays in human, mouse, rat INADL

    Additional mRNA sequence: 

    AF397170.1 AJ001306.1 AJ224747.1 AJ224748.1 AK293519.1 AK294187.1 AK304355.1 AK307713.1 
    AK308428.1 AK308665.1 BC021135.1 BC142661.1 BC142723.1 BC144135.1 

    18 DOTS entries:

    DT.110720  DT.100781932  DT.121419068  DT.97789417  DT.70104727  DT.119248  DT.100721371  DT.97833684 
    DT.121419091  DT.40314090  DT.97789428  DT.75154718  DT.75192209  DT.91674136  DT.91748005  DT.95362168 
    DT.40250926  DT.75189274 

    Selected AceView cDNA sequences (see all 155):

    CB047676 NM_176877 BE073929 BE501835 AW305081 AI392921 BU678903 CD356816 
    NM_176878 BE392595 NM_005799 AJ224747 AI631843 AJ224748 AI601105 BF475257 
    AA843633 BF331554 AI765784 AA357999 AU132556 BQ439979 NM_170605 AA777657 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for INADL (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47
    SP1:        -                 -                                   -                 -                                                         
    SP2:        -                 -                                                                                                               
    SP3:        -                 -                                   -                                                                           
    SP4:        -                 -                                   -     -                                                                     
    SP5:        -                 -                                   -                 -                                                         


    ECgene alternative splicing isoforms for INADL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INADL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    INADL Expression
    About this image

    INADL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INADL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.478125

    UniProtKB/Swiss-Prot: INADL_HUMAN, Q8NI35
    Tissue specificity: Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas
    and cerebellum in the brain

        Pathway & Disease-focused RT2 Profiler PCR Array including INADL: 
              Tight Junctions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INADL gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inadl1 , 5 InaD-like (Drosophila)1, 5 81.87(n)1
    81.2(a)1
      4 (45.60 cM)5
    126951  NM_172696.21  NP_766284.21 
     983957855 
    chicken
    (Gallus gallus)
    Aves INADL1 InaD-like (Drosophila) 70.03(n)
    68.35(a)
      424682  XM_004936854.1  XP_004936911.1 
    lizard
    (Anolis carolinensis)
    Reptilia INADL6
    InaD-like (Drosophila)
    61(a)
    1 ↔ 1
    4(100116045-100312720)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480234012   -- 73.88(n)    48023401 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.206032 Transcribed sequence with weak similarity to protein more 78.35(n)    57092330 
    fruit fly
    (Drosophila melanogaster)
    Insecta Patj6
    Patj
    31(a)
    1 ↔ 1
    3L(1798803-1802184)
    worm
    (Caenorhabditis elegans)
    Secernentea mpz-16
    Protein MPZ-1, isoform b (C52A11.5) mRNA, complete...
    19(a)
    1 ↔ 1
    II(10738647-10775061) WBGene00003404


    ENSEMBL Gene Tree for INADL (if available)
    TreeFam Gene Tree for INADL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INADL gene
    PARD3B2  IL162  PDZD22  LNX22  PARD32  MPDZ2  LNX12  
    6 SIMAP similar genes for INADL using alignment to 4 protein entries:     INADL_HUMAN (see all proteins):
    DLG4    MPDZ    TJP2    ARHGAP23    SYNJ2BP    DLG2

    Find genes that share paralogs with INADL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INADL (see all 8835)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs671822321,2
    C--60430879(+) GATCA-/GCACGACC 1 -- int10--------
    rs1466890021,2
    C--62206252(+) ACAGAA/GCGAGA 1 -- us2k10--------
    rs1122061771,2
    C--62206283(+) ACAAC-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs11517781,2
    C--62206358(+) ccaggT/Caataa 1 -- us2k1 tfbs38Minor allele frequency- C:0.00NA WA CSA 14
    rs12904411,2
    C,F,A,H--62206567(+) TCCATC/TTGGCA 1 -- us2k19Minor allele frequency- T:0.15NS EA NA CSA WA 541
    rs11517791,2
    C,F--62206620(-) TGGTTT/CCTGCT 1 -- us2k15Minor allele frequency- C:0.32NA CSA WA 125
    rs1498761141,2
    --62206644(+) TGTCTA/TCTTAC 1 -- us2k10--------
    rs120749121,2
    C,F--62206678(+) CTTTTA/CAAACA 1 -- us2k1 tfbs31Minor allele frequency- C:0.06WA 118
    rs1449203951,2
    C--62206859(+) CTCCGA/GGCTAA 1 -- us2k10--------
    rs1132969521,2
    C--62206897(+) TTGAGG/ACGGGG 1 -- us2k11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for INADL (62208149 - 62458149 bp, first 250kb of INADL)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for INADL (see all 36):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673058CNV Deletion23128226
    esv2748974CNV Deletion23290073
    esv2472996CNV Deletion19546169
    esv2663885CNV Deletion23128226
    esv5270CNV Deletion18987735
    esv2421746CNV Deletion20811451
    esv1040191CNV Deletion17803354
    esv2549769CNV Deletion19546169
    esv2670379CNV Deletion23128226
    esv1003515CNV Deletion20482838

    Human Gene Mutation Database (HGMD): INADL
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INADL
    DNA2.0 Custom Variant and Variant Library Synthesis for INADL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603199    OMIM disorders: --


    Find genes that share disorders with INADL           About GenesLikeMe

    3 Novoseek inferred disease relationships for INADL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal degeneration 29.1 1 15755798 (1)
    cystic fibrosis 9.81 1 11707463 (1)
    tumors 0 2 19015633 (1)

    Genetic Association Database (GAD): INADL
    Human Genome Epidemiology (HuGE) Navigator: INADL (1 document)

    Export disorders for INADL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INADL gene, integrated from 10 sources (see all 126):
    (articles sorted by number of sources associating them with INADL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of a novel PDZ domain protein with homology to INAD from Drosophila melanogaster. (PubMed id 9280290)1, 2, 3, 9 Philipp S. and Flockerzi V. (FEBS Lett. 1997)
    2. Isolation of novel heart-specific genes using the BodyMap database. (PubMed id 11374908)1, 2, 3 Soejima H.... Mukai T. (Genomics 2001)
    3. The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. (PubMed id 11927608)1, 2, 9 Roh M.H.... Margolis B. (J. Cell Biol. 2002)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. KIBRA modulates directional migration of podocytes. (PubMed id 18596123)1, 2 Duning K.... Pavenstaedt H. (J. Am. Soc. Nephrol. 2008)
    6. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. (PubMed id 16678097)1, 2 Wells C.D.... Pawson T. (Cell 2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes. (PubMed id 15241471)1, 2 Li Y.... Lavie A. (EMBO J. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions. (PubMed id 12021270)1, 2 Roh M.H.... Margolis B. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10207 HGNC: 28881 AceView: INADL Ensembl:ENSG00000132849 euGenes: HUgn10207
    ECgene: INADL Kegg: 10207 H-InvDB: INADL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for INADL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INADL gene:
    Search GeneIP for patents involving INADL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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