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Aliases for INADL Gene

Aliases for INADL Gene

  • InaD-Like (Drosophila) 2 3
  • PATJ 3 4 6
  • Protein Associated To Tight Junctions 3 4
  • HINADL 3 4
  • Inactivation No After-Potential D-Like Protein 3
  • PALS1-Associated Tight Junction Protein 3
  • Pals1-Associated Tight Junction Protein 4
  • Channel-Interacting PDZ Domain Protein 3
  • PDZ Domain Protein 3
  • InaD-Like Protein 3
  • Inadl Protein 4
  • InaD-Like 3
  • Cipp 3

External Ids for INADL Gene

Summaries for INADL Gene

Entrez Gene Summary for INADL Gene

  • This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for INADL Gene

INADL (InaD-Like (Drosophila)) is a Protein Coding gene. Among its related pathways are Hippo signaling pathway and Cell junction organization. An important paralog of this gene is PARD3B.

UniProtKB/Swiss-Prot for INADL Gene

  • Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons.

Gene Wiki entry for INADL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INADL Gene

Genomics for INADL Gene

Genomic Location for INADL Gene

Start:
61,742,477 bp from pter
End:
62,163,920 bp from pter
Size:
421,444 bases
Orientation:
Plus strand

Genomic View for INADL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INADL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INADL Gene

Regulatory Elements for INADL Gene

Proteins for INADL Gene

  • Protein details for INADL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI35-INADL_HUMAN
    Recommended name:
    InaD-like protein
    Protein Accession:
    Q8NI35
    Secondary Accessions:
    • O15249
    • O43742
    • O60833
    • Q5VUA5
    • Q5VUA6
    • Q5VUA7
    • Q5VUA8
    • Q5VUA9
    • Q5VUB0
    • Q8WU78
    • Q9H3N9

    Protein attributes for INADL Gene

    Size:
    1801 amino acids
    Molecular mass:
    196368 Da
    Quaternary structure:
    • Interacts with ASIC3, KCNJ10, KCNJ15, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NLGN2, MPP7, HTR2A and SLC6A4 (By similarity). Forms a ternary complex with MPP5, CRB1 and CRB3. Interacts with TJP3/ZO-3 and CLDN1/claudin-1. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Directly interacts with HTR4 (By similarity). Interacts (via PDZ domain 8) with WWC1 (via the ADDV motif).
    SequenceCaution:
    • Sequence=CAH70416.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21733.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22258.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for INADL Gene

    Alternative splice isoforms for INADL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INADL Gene

Proteomics data for INADL Gene at MOPED

Post-translational modifications for INADL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INADL Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for INADL Gene

Domains for INADL Gene

Protein Domains for INADL Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

INADL_HUMAN
Domain:
  • The L27 domain (also called Maguk recruitment domain) is required for interaction with MPP5 and CRB3, and MPP5 localization to tight junctions:
    • Q8NI35
  • The PDZ domain 6 mediates interaction with the C-terminus of TJP3 and is crucial for localization to the tight junctions. The PDZ domain 8 interacts with CLDN1 but is not required for proper localization:
    • Q8NI35
  • Contains 1 L27 domain.:
    • Q8NI35
  • Contains 10 PDZ (DHR) domains.:
    • Q8NI35
genes like me logo Genes that share domains with INADL: view

No data available for Gene Families for INADL Gene

Function for INADL Gene

Molecular function for INADL Gene

UniProtKB/Swiss-Prot Function: Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons.

Gene Ontology (GO) - Molecular Function for INADL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11927608
genes like me logo Genes that share ontologies with INADL: view

miRNA for INADL Gene

miRTarBase miRNAs that target INADL

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for INADL Gene

Localization for INADL Gene

Subcellular locations from UniProtKB/Swiss-Prot for INADL Gene

Membrane. Cell junction, tight junction. Apical cell membrane. Cytoplasm, perinuclear region. Note=Localized in the paranodal region of myelinating Schwann cells (By similarity). Membrane-associated. Localizes to tight junctions in epithelial cells. Also found at the apical plasma membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INADL Gene COMPARTMENTS Subcellular localization image for INADL gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for INADL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005923 bicellular tight junction IDA 22006950
GO:0016324 apical plasma membrane IEA --
GO:0043234 protein complex IEA --
GO:0045177 apical part of cell --
genes like me logo Genes that share ontologies with INADL: view

Pathways for INADL Gene

genes like me logo Genes that share pathways with INADL: view

Pathways by source for INADL Gene

Gene Ontology (GO) - Biological Process for INADL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034329 cell junction assembly TAS --
GO:0035556 intracellular signal transduction NAS 9280290
GO:0045216 cell-cell junction organization TAS --
GO:0070830 bicellular tight junction assembly TAS --
genes like me logo Genes that share ontologies with INADL: view

Compounds for INADL Gene

(6) Novoseek inferred chemical compound relationships for INADL Gene

Compound -log(P) Hits PubMed IDs
nmda 30.5 5
tyrosine 25.5 2
glutamate 20.3 1
calcium 0 4
potassium 0 1
genes like me logo Genes that share compounds with INADL: view

Transcripts for INADL Gene

Unigene Clusters for INADL Gene

InaD-like (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INADL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47
SP1: - - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - - -
SP6: - -
SP7: -
SP8:

Relevant External Links for INADL Gene

GeneLoc Exon Structure for
INADL
ECgene alternative splicing isoforms for
INADL

Expression for INADL Gene

mRNA expression in normal human tissues for INADL Gene

mRNA differential expression in normal tissues according to GTEx for INADL Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.8) and Brain - Cerebellum (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INADL Gene

SOURCE GeneReport for Unigene cluster for INADL Gene Hs.478125

mRNA Expression by UniProt/SwissProt for INADL Gene

Q8NI35-INADL_HUMAN
Tissue specificity: Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain.
genes like me logo Genes that share expressions with INADL: view

Orthologs for INADL Gene

This gene was present in the common ancestor of animals.

Orthologs for INADL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INADL 36
  • 99.37 (n)
  • 99.16 (a)
INADL 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INADL 36
  • 88.44 (n)
  • 87.44 (a)
INADL 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INADL 36
  • 89.98 (n)
  • 88.57 (a)
INADL 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inadl 36
  • 81.87 (n)
  • 81.2 (a)
Inadl 16
Inadl 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INADL 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INADL 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inadl 36
  • 81.82 (n)
  • 81.2 (a)
chicken
(Gallus gallus)
Aves INADL 36
  • 70.03 (n)
  • 68.35 (a)
INADL 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INADL 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia inadl 36
  • 64.71 (n)
  • 62.03 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1952 36
zebrafish
(Danio rerio)
Actinopterygii Dr.20603 36
inadl 36
  • 58.86 (n)
  • 59.2 (a)
inadl 37
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Patj 37
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mpz-1 37
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToMany
CSA.5918 37
  • 30 (a)
OneToMany
Species with no ortholog for INADL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INADL Gene

ENSEMBL:
Gene Tree for INADL (if available)
TreeFam:
Gene Tree for INADL (if available)

Paralogs for INADL Gene

Paralogs for INADL Gene

Selected SIMAP similar genes for INADL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with INADL: view

Variants for INADL Gene

Sequence variations from dbSNP and Humsavar for INADL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1363 -- 62,052,250(-) AAACC(C/T)GAAAG intron-variant
rs2938 -- 61,865,716(+) GGAAA(C/T)AGACT intron-variant
rs505903 -- 61,781,086(+) ATTGC(C/T)CTAGG intron-variant
rs525526 -- 61,777,472(-) ggctc(A/G)aagca intron-variant
rs535242 -- 61,780,151(-) AATGA(A/G)CATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INADL Gene

Variant ID Type Subtype PubMed ID
nsv830004 CNV Gain 17160897
esv2670379 CNV Deletion 23128226
nsv1099 CNV Loss 18451855
esv2673058 CNV Deletion 23128226
dgv6n21 CNV Loss 19592680
esv1631480 CNV Insertion 17803354
esv2549769 CNV Deletion 19546169
esv2323512 CNV Deletion 18987734
esv5270 CNV Deletion 18987735
nsv159038 CNV Loss 16902084
esv2472996 CNV Deletion 19546169
esv2748974 CNV Deletion 23290073
esv6133 CNV Loss 19470904
esv1003515 CNV Deletion 20482838
esv1040191 CNV Deletion 17803354
nsv1110 CNV Loss 18451855
esv29630 CNV Loss 19812545
nsv437210 CNV Loss 16327808
nsv10217 CNV Loss 18304495
nsv517696 CNV Loss 19592680
nsv437211 CNV Loss 16327808
esv2667576 CNV Deletion 23128226
esv26149 CNV Loss 19812545
nsv818189 CNV Loss 17921354
esv2421746 CNV Deletion 20811451
nsv438388 CNV Loss 16468122
esv2659941 CNV Deletion 23128226
esv268426 CNV Insertion 20981092
esv2748985 CNV Deletion 23290073
esv2514338 CNV Insertion 19546169
esv1091714 CNV Insertion 17803354
nsv822998 CNV Loss 20364138
nsv511694 CNV Loss 21212237
esv2672562 CNV Deletion 23128226
esv997498 CNV Gain 20482838
esv2663885 CNV Deletion 23128226

Relevant External Links for INADL Gene

HapMap Linkage Disequilibrium report
INADL
Human Gene Mutation Database (HGMD)
INADL

Disorders for INADL Gene

(3) Novoseek inferred disease relationships for INADL Gene

Disease -log(P) Hits PubMed IDs
retinal degeneration 29.1 1
cystic fibrosis 9.81 1
tumors 0 1

Relevant External Links for INADL

Genetic Association Database (GAD)
INADL
Human Genome Epidemiology (HuGE) Navigator
INADL
genes like me logo Genes that share disorders with INADL: view

No data available for UniProtKB/Swiss-Prot for INADL Gene

Publications for INADL Gene

  1. Molecular characterization of a novel PDZ domain protein with homology to INAD from Drosophila melanogaster. (PMID: 9280290) Philipp S. … Flockerzi V. (FEBS Lett. 1997) 2 3 4 23
  2. Isolation of novel heart-specific genes using the BodyMap database. (PMID: 11374908) Soejima H. … Mukai T. (Genomics 2001) 2 3 4
  3. The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. (PMID: 11927608) Roh M.H. … Margolis B. (J. Cell Biol. 2002) 3 4 23
  4. CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. (PMID: 9647694) Kurschner C. … Surmeier D.J. (Mol. Cell. Neurosci. 1998) 3 23
  5. PATJ, a tight junction-associated PDZ protein, is a novel degradation target of high-risk human papillomavirus E6 and the alternatively spliced isoform 18 E6. (PMID: 17287269) Storrs C.H. … Silverstein S.J. (J. Virol. 2007) 3 23

Products for INADL Gene

Sources for INADL Gene

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