Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



INA Gene

protein-coding   GIFtS: 59
GCID: GC10P105026

Internexin Neuronal Intermediate Filament Protein, Alpha


(Previous symbol: NEF5)
  See INA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Internexin Neuronal Intermediate Filament Protein, Alpha1 2     alpha-internexin2
NEF51 2 3     Neurofilament 5 (66kD)2
66 KDa Neurofilament Protein2 3     Neurofilament-66, Tax-Binding Protein2
NF-662 3     Alpha-Inx3
TXBP-12     Neurofilament-663
alpha-Inx2     Neurofilament 53

External Ids:    HGNC: 60571   Entrez Gene: 91182   Ensembl: ENSG000001487987   OMIM: 6053385   UniProtKB: Q163523   

Export aliases for INA gene to outside databases

Previous GC identifers: GC10P103930 GC10P104270 GC10P105168 GC10P104701 GC10P098669


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for INA Gene:
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains.
Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a
role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family
and is involved in the morphogenesis of neurons. (provided by RefSeq, Jun 2009)

GeneCards Summary for INA Gene:
INA (internexin neuronal intermediate filament protein, alpha) is a protein-coding gene. Diseases associated with INA include prostate small cell carcinoma, and medulloepithelioma. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is LMNB1.

UniProtKB/Swiss-Prot: AINX_HUMAN, Q16352
Function: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the
morphogenesis of neurons. It may form an independent structural network without the involvement of other
neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to
form the cross-bridges




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the INA gene promoter:
         GR   NF-1   NF-1/L   GR-beta   CBF-C   GATA-2   CBF-B   CBF-A   GR-alpha   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINA promoter sequence
   Search Chromatin IP Primers for INA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.33   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q24

INA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INA gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P105026:  view genomic region     (about GC identifiers)

Start:
105,036,920 bp from pter      End:
105,050,108 bp from pter
Size:
13,189 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AINX_HUMAN, Q16352 (See protein sequence)
Recommended Name: Alpha-internexin  
Size: 499 amino acids; 55391 Da
Developmental stage: Expressed in brain as early as the 16th week of gestation, and increased rapidly and reached
a steady state level by the 18th week of gestation
Secondary accessions: B1AQK0 Q9BRC5

Explore the universe of human proteins at neXtProt for INA: NX_Q16352

Explore proteomics data for INA at MOPED

Post-translational modifications: 

  • O-glycosylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See INA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116116.1  
    ENSEMBL proteins: 
     ENSP00000358865  

    INA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for INA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for INA
    GenScript Custom Purified and Recombinant Proteins Services for INA
    Novus Biologicals INA Protein
    Novus Biologicals INA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for INA 

    INA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of INA
    R&D Systems Antibodies for INA (alpha-Internexin)
    OriGene Antibodies for INA
    OriGene Custom Antibody Services for INA
    Novus Biologicals INA Antibodies
    Abcam antibodies for INA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for INA
    LSBio Antibodies in human, mouse, rat for INA

    INA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for INA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for INA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for INA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IFF4: Intermediate filaments type IV

    4 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR027703 Alpha-Inx
     IPR006821 Intermed_filament_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q16352

    ProtoNet protein and cluster: Q16352

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: AINX_HUMAN, Q16352
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with INA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AINX_HUMAN, Q16352
    Function: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the
    morphogenesis of neurons. It may form an independent structural network without the involvement of other
    neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to
    form the cross-bridges

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity ----
    GO:0005200structural constituent of cytoskeleton TAS7769995
    GO:0005515protein binding ----
         
    Find genes that share ontologies with INA           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for INA:
     Increased cell number in G1, s 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ina):
     nervous system  normal 

    Find genes that share phenotypes with INA           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INA

    miRNA
    Products:
        
    miRTarBase miRNAs that target INA:
    hsa-mir-124-3p (MIRT022315), hsa-mir-128-3p (MIRT021884), hsa-mir-101-3p (MIRT027268), hsa-mir-155-5p (MIRT020605)

    Block miRNA regulation of human, mouse, rat INA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INA (see all 23):
    hsa-miR-3164 hsa-miR-448 hsa-miR-642a hsa-miR-1288 hsa-miR-1271 hsa-miR-29c hsa-miR-29a hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidINA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INA
    Predesigned siRNA for gene silencing in human, mouse, rat INA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for INA

    Clone
    Products:
         
    OriGene clones in human, mouse for INA (see all 7)
    OriGene ORF clones in mouse, rat for INA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INA (NM_001085)
    Sino Biological Human cDNA Clone for INA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for INA
    Browse ESI BIO Cell Lines and PureStem Progenitors for INA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    nucleus3
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005882intermediate filament ----
    GO:0005883neurofilament IEA--

    Find genes that share ontologies with INA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for INA About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoskeleton remodeling Neurofilaments0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for INA
        Cytoskeleton remodeling Neurofilaments



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INA
    Interactions:

        Search GeneGlobe Interaction Network for INA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for INA (Q163523 ENSP000003588654) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIN1Q055863, ENSP000003606164I2D: score=4 STRING: ENSP00000360616
    SQSTM1Q135013, ENSP000003744554I2D: score=3 STRING: ENSP00000374455
    GRIN2DO153993, ENSP000002632694I2D: score=1 STRING: ENSP00000263269
    TANC1Q9C0D53, ENSP000002636354I2D: score=1 STRING: ENSP00000263635
    STAU1O957933, ENSP000003609224I2D: score=4 STRING: ENSP00000360922
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development ----
    GO:0021762substantia nigra development IEP--
    GO:0030154cell differentiation IEA--
    GO:0045104intermediate filament cytoskeleton organization ----
    GO:0060052neurofilament cytoskeleton organization IEA--

    Find genes that share ontologies with INA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INA (AINX)

    3 Novoseek inferred chemical compound relationships for INA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 12.4 2 7609647 (2)
    opiate 10.2 1 14969742 (1)
    calcium 0 1 9482252 (1)



    Find genes that share compounds with INA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for INA gene: 
    NM_032727.3  

    Unigene Cluster for INA:

    Internexin neuronal intermediate filament protein, alpha
    Hs.500916  [show with all ESTs]
    Unigene Representative Sequence: NM_032727
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369849(uc009xxj.3 uc001kws.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat INA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INA (see all 23):
    hsa-miR-3164 hsa-miR-448 hsa-miR-642a hsa-miR-1288 hsa-miR-1271 hsa-miR-29c hsa-miR-29a hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidINA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for INA
    Predesigned siRNA for gene silencing in human, mouse, rat INA
    Clone
    Products:
         
    OriGene clones in human, mouse for INA (see all 7)
    OriGene ORF clones in mouse, rat for INA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INA (NM_001085)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for INA
    OriGene qSTAR qPCR primer pairs in human, mouse for INA
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat INA
      QuantiTect SYBR Green Assays in human, mouse, rat INA
      QuantiFast Probe-based Assays in human, mouse, rat INA

    Additional mRNA sequence: 

    AB209785.1 AK293490.1 AK311620.1 BC006359.2 S78296.1 

    8 DOTS entries:

    DT.316335  DT.100803480  DT.97820084  DT.97820643  DT.100809962  DT.95096205  DT.100672227  DT.40266245 

    Selected AceView cDNA sequences (see all 144):

    BM720667 BF447588 N78535 AI879375 BX281645 BM676458 BU736437 BM679369 
    AI216734 AA621661 AW157033 BQ892997 BU738821 CB132103 BM713757 BC006359 
    AI589857 BF593926 AA084642 AA962249 NM_032727 BF448968 CA848830 AW157275 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    INA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCAATAGT
    INA Expression
    About this image


    INA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Horizontal Cells Inner Nuclear Layer
             Retina
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Gonad (Reproductive System)    fully expand to see all 2 entries
             Primordial Germ Cells Primitive Gonad
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
    INA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500916

    UniProtKB/Swiss-Prot: AINX_HUMAN, Q16352
    Tissue specificity: Found predominantly in adult CNS

        Custom PCR Arrays for INA
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for INA
    OriGene qSTAR qPCR primer pairs in human, mouse for INA
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat INA
    QuantiTect SYBR Green Assays in human, mouse, rat INA
    QuantiFast Probe-based Assays in human, mouse, rat INA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for INA gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ina1 , 5 internexin neuronal intermediate filament protein, more1, 5 90.05(n)1
    94.19(a)1
      19 (39.07 cM)5
    2261801  NM_146100.41  NP_666212.31 
     470146985 
    chicken
    (Gallus gallus)
    Aves INA6
    internexin neuronal intermediate filament protein,...
    43(a)
    1 ↔ 1
    6(23104676-23106678)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    44(a)
    1 → many
    3(40591073-40593702)
    African clawed frog
    (Xenopus laevis)
    Amphibia ina-A2 internexin neuronal intermediate filament protein, more 75.4(n)    U63711.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gefiltin2 gefiltin 78.29(n)   30230  NM_131032.1 


    ENSEMBL Gene Tree for INA (if available)
    TreeFam Gene Tree for INA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for INA gene
    LMNB12  VIM2  LMNA2  PRPH2  NEFM2  DES2  LMNB22  NEFH2  
    GFAP2  
    Selected SIMAP similar genes for INA using alignment to 1 protein entry:     AINX_HUMAN(see all similar genes):
    GFAP    VIM    DES    tmp_locus_29    NEFM    NEFL
    PRPH    DKFZp761K0922    NEFH    KRT5    KRT75    KRT3
    KRT8    KRT81    KRT83    KRT86    KRT13    KRT16

    Find genes that share paralogs with INA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for INA (see all 299)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363694
    A breast cancer sample4--see VAR_0363692 E Q mis40--------
    rs352140961,2
    C--105043083(+) AGCTA-/AGAGGG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs710196751,2
    C--105046093(-) TTTTTT/-TTTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs761378811,2
    C--105046118(+) AAAAA-/G/GA  
            
    ATTCC
    1 -- int10--------
    rs355207641,2
    C--105046451(+) AAAATA/-CATCT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs79069771,2
    C,F--105396723(+) aactcC/Tgtctc 1 -- us2k12Minor allele frequency- T:0.21WA 120
    rs1164198601,2
    F--105396777(+) AATTAT/CGTAGT 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1446663281,2
    --105396835(+) CACCCA/GCACCT 1 -- us2k10--------
    rs1915667241,2
    --105396964(+) ATCTTC/TTATTG 1 -- us2k10--------
    rs792261011,2
    F--105396982(+) TACCAG/CGTCTT 1 -- us2k12Minor allele frequency- C:0.03CSA WA 120

    HapMap Linkage Disequilibrium report for INA (105036920 - 105050108 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for INA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509365CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INA
    DNA2.0 Custom Variant and Variant Library Synthesis for INA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605338    OMIM disorders: --

    5 diseases for INA:    
    About MalaCards
    prostate small cell carcinoma    medulloepithelioma    wernicke encephalopathy    hypothalamic hamartomas
    gliomatosis cerebri

    2 diseases from the University of Copenhagen DISEASES database for INA:
    Cerebrovascular accident     Prostate small cell carcinoma

    Find genes that share disorders with INA           About GenesLikeMe

    10 Novoseek inferred disease relationships for INA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cmv infection 69.5 11 15170578 (2), 16722980 (1), 15883343 (1), 16005115 (1) (see all 9)
    frontotemporal dementia 66.5 5 15170578 (2), 19669651 (1), 16005115 (1)
    motor neuron disease 58.2 2 15170578 (2)
    tauopathies 55.8 1 15170578 (1)
    neurodegenerative diseases 36 5 15170578 (3), 16911480 (1)
    neurological disorders 28.5 5 15170578 (2), 15161649 (1), 16005115 (1)
    astrocytoma 16.2 1 16598485 (1)
    alzheimers disease 10.8 3 15686957 (2), 15170578 (1)
    shock 0 3 19898260 (1), 15731543 (1), 9482252 (1)
    tumors 0 11 19139367 (2), 18528283 (2), 8078299 (1), 18492260 (1) (see all 5)

    Genetic Association Database (GAD): INA
    Human Genome Epidemiology (HuGE) Navigator: INA (12 documents)

    Export disorders for INA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for INA gene, integrated from 10 sources (see all 111):
    (articles sorted by number of sources associating them with INA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and developmental expression of human 66 kd neurofilament protein. (PubMed id 7769995)1, 2, 3, 9 Chan S.-O. and Chiu F.-C. (Brain Res. Mol. Brain Res. 1995)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. alpha-Internexin expression identifies 1p19q codeleted gliomas. (PubMed id 19139367)1, 9 Ducray F....Sanson M. (Neurology 2009)
    5. A comparative immunohistochemical analysis of small round cell tumors of childhood: utility of peripherin and alpha-internexin as markers for neuroblastomas. (PubMed id 18528283)1, 9 Willoughby V....Donner L.R. (amp 2008)
    6. alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease. (PubMed id 15161649)1, 9 Cairns N.J....Trojanowski J.Q. (Am. J. Pathol. 2004)
    7. Specific interaction of HTLV tax protein and a human type IV neuronal intermediate filament protein. (PubMed id 9435256)1, 9 Reddy T.R....Wong-Staal F. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    8. Topography of alpha-internexin-positive neuronal aggregates in 10 patients with neuronal intermediate filament inclusion disease. (PubMed id 16722980)1, 9 Armstrong R.A. and Cairns N.J. (Eur. J. Neurol. 2006)
    9. Expression of neuronal and glial polypeptides during histogenesis of the human cerebellar cortex including observations on the dentate nucleus. (PubMed id 7690783)1, 9 Yachnis A.T....Trojanowski J.Q. (J. Comp. Neurol. 1993)
    10. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9118 HGNC: 6057 AceView: INA Ensembl:ENSG00000148798 euGenes: HUgn9118
    ECgene: INA H-InvDB: INA

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for INA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for INA gene:
    Search GeneIP for patents involving INA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of INA
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for INA (alpha-Internexin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for INA   OriGene RNAi products in human, mouse, rat for INA  
     OriGene qPCR primer pairs and template standards for INA   OriGene Protein Over-expression Lysate for INA  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for INA  
     OriGene qSTAR qPCR primer pairs in human, mouse for INA   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for INA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for INA   OriGene Custom Protein Services for INA  

     
     
     Block miRNA regulation of human, mouse, rat INA using miScript Target Protectors SeqTarget long-range PCR primers for resequencing INA
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INA Predesigned siRNA for gene silencing in human, mouse, rat INA
     QuantiFast Probe-based Assays in human, mouse, rat INA QuantiTect SYBR Green Assays in human, mouse, rat INA
     Custom PCR Arrays for INA Search Chromatin IP Primers for INA
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat INA  Search GeneGlobe Interaction Network for INA
     Regulatory tfbs in INA promoter
     GenScript Custom Purified and Recombinant Proteins Services for INA GenScript cDNA clones with any tag delivered in your preferred vector for INA
     GenScript Custom Assay Services for INA GenScript Custom overexpressing Cell Line Services for INA
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for INA (AINX)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for INA
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     INA antibodies
     INA proteins
     INA lysates
     Antibodies for INA
     See all of Abcam's Antibodies, Kits and Proteins for INA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for INA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INA
     SwitchGear 3'UTR luciferase reporter plasmids for INA
     SwitchGear Promoter luciferase reporter plasmids for INA
     ThermoFisher Antibody for INA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INA
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INA
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INA
     LSBio Antibodies in human, mouse, rat for INA
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for INA
      Search eBioscience for proteins for INA
      Search eBioscience for elisas for INA
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      INA gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4