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Aliases for INA Gene

Aliases for INA Gene

  • Internexin Neuronal Intermediate Filament Protein, Alpha 2 3
  • 66 KDa Neurofilament Protein 3 4
  • Alpha-Inx 3 4
  • NF-66 3 4
  • NEF5 3 4
  • Neurofilament-66, Tax-Binding Protein 3
  • Neurofilament 5 (66kD) 3
  • Neurofilament-66 4
  • Neurofilament 5 4
  • TXBP-1 3

External Ids for INA Gene

Previous HGNC Symbols for INA Gene

  • NEF5

Previous GeneCards Identifiers for INA Gene

  • GC10P103930
  • GC10P104270
  • GC10P105168
  • GC10P104701
  • GC10P105026
  • GC10P098669

Summaries for INA Gene

Entrez Gene Summary for INA Gene

  • Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]

GeneCards Summary for INA Gene

INA (Internexin Neuronal Intermediate Filament Protein, Alpha) is a Protein Coding gene. Diseases associated with INA include hypothalamic hamartomas and medullomyoblastoma. Among its related pathways are Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is LMNB2.

UniProtKB/Swiss-Prot for INA Gene

  • Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INA Gene

Genomics for INA Gene

Regulatory Elements for INA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for INA Gene

Chromosome:
10
Start:
103,277,163 bp from pter
End:
103,290,351 bp from pter
Size:
13,189 bases
Orientation:
Plus strand

Genomic View for INA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INA Gene

Proteins for INA Gene

  • Protein details for INA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16352-AINX_HUMAN
    Recommended name:
    Alpha-internexin
    Protein Accession:
    Q16352
    Secondary Accessions:
    • B1AQK0
    • Q9BRC5

    Protein attributes for INA Gene

    Size:
    499 amino acids
    Molecular mass:
    55391 Da
    Quaternary structure:
    No Data Available

neXtProt entry for INA Gene

Proteomics data for INA Gene at MOPED

Post-translational modifications for INA Gene

Other Protein References for INA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for INA (alpha-Internexin)

No data available for DME Specific Peptides for INA Gene

Domains & Families for INA Gene

Gene Families for INA Gene

Suggested Antigen Peptide Sequences for INA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16352

UniProtKB/Swiss-Prot:

AINX_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with INA: view

Function for INA Gene

Molecular function for INA Gene

UniProtKB/Swiss-Prot Function:
Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges

Gene Ontology (GO) - Molecular Function for INA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity --
GO:0005200 structural constituent of cytoskeleton TAS 7769995
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with INA: view
genes like me logo Genes that share phenotypes with INA: view

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for INA Gene

Localization for INA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INA Gene COMPARTMENTS Subcellular localization image for INA gene
Compartment Confidence
extracellular 5
cytoskeleton 4
nucleus 4

Gene Ontology (GO) - Cellular Components for INA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005654 nucleoplasm IDA --
GO:0005882 intermediate filament --
GO:0005883 neurofilament IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with INA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for INA Gene

Pathways & Interactions for INA Gene

genes like me logo Genes that share pathways with INA: view

Pathways by source for INA Gene

1 GeneGo (Thomson Reuters) pathway for INA Gene

Gene Ontology (GO) - Biological Process for INA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development --
GO:0021762 substantia nigra development IEP 22926577
GO:0030154 cell differentiation IEA --
GO:0045104 intermediate filament cytoskeleton organization --
GO:0060052 neurofilament cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with INA: view

No data available for SIGNOR curated interactions for INA Gene

Drugs & Compounds for INA Gene

(1) Drugs for INA Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0

(2) Additional Compounds for INA Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Opiate
retinoic acid
302-79-4
genes like me logo Genes that share compounds with INA: view

Transcripts for INA Gene

mRNA/cDNA for INA Gene

Unigene Clusters for INA Gene

Internexin neuronal intermediate filament protein, alpha:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INA Gene

No ASD Table

Relevant External Links for INA Gene

GeneLoc Exon Structure for
INA
ECgene alternative splicing isoforms for
INA

Expression for INA Gene

mRNA expression in normal human tissues for INA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INA Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.1), Brain - Hypothalamus (x5.6), Brain - Cortex (x5.4), and Brain - Anterior cingulate cortex (BA24) (x5.2).

Protein differential expression in normal tissues from HIPED for INA Gene

This gene is overexpressed in Fetal Brain (20.3), Brain (14.0), Frontal cortex (13.3), and Spinal cord (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for INA Gene



SOURCE GeneReport for Unigene cluster for INA Gene Hs.500916

mRNA Expression by UniProt/SwissProt for INA Gene

Q16352-AINX_HUMAN
Tissue specificity: Found predominantly in adult CNS
genes like me logo Genes that share expression patterns with INA: view

Protein tissue co-expression partners for INA Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for INA Gene

This gene was present in the common ancestor of chordates.

Orthologs for INA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia INA 35
  • 94.39 (n)
  • 97.19 (a)
INA 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INA 35
  • 94.12 (n)
  • 96.59 (a)
INA 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ina 35
  • 90.05 (n)
  • 94.19 (a)
Ina 16
Ina 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia INA 35
  • 99.53 (n)
  • 99.8 (a)
INA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ina 35
  • 91.52 (n)
  • 95.39 (a)
oppossum
(Monodelphis domestica)
Mammalia INA 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INA 36
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves INA 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ina 35
  • 68.37 (n)
  • 67.87 (a)
Str.8421 35
African clawed frog
(Xenopus laevis)
Amphibia ina-A 35
zebrafish
(Danio rerio)
Actinopterygii gefiltin 35
INA (2 of 3) 36
  • 43 (a)
OneToMany
inaa 36
  • 58 (a)
OneToMany
inab 36
  • 58 (a)
OneToMany
Species with no ortholog for INA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INA Gene

ENSEMBL:
Gene Tree for INA (if available)
TreeFam:
Gene Tree for INA (if available)

Paralogs for INA Gene

Paralogs for INA Gene

genes like me logo Genes that share paralogs with INA: view

Variants for INA Gene

Sequence variations from dbSNP and Humsavar for INA Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs908647 -- 103,286,729(+) GTTCA(A/G)AACTA intron-variant
rs1063454 -- 103,277,400(+) CTCGG(A/C)CTGGC synonymous-codon, reference
rs1063455 - 103,277,485(+) TCCGC(A/T)CCAAC reference, missense
rs1063456 - 103,277,656(+) TGCGC(C/G)ACCTG missense, reference
rs1063457 -- 103,277,998(+) TGACC(G/T)CGGCT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for INA Gene

Variant ID Type Subtype PubMed ID
nsv509365 CNV Insertion 20534489

Variation tolerance for INA Gene

Residual Variation Intolerance Score: 42.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INA Gene

HapMap Linkage Disequilibrium report
INA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INA Gene

Disorders for INA Gene

MalaCards: The human disease database

(5) MalaCards diseases for INA Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hypothalamic hamartomas
  • hamartoma of the hypothalamus
medullomyoblastoma
dementia, frontotemporal
  • dementia, frontotemporal, with or without parkinsonism
motor neuron disease
  • motor neuron diseases
tauopathy
  • tauopathies
- elite association
Search INA in MalaCards View complete list of genes associated with diseases

Relevant External Links for INA

Genetic Association Database (GAD)
INA
Human Genome Epidemiology (HuGE) Navigator
INA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INA
genes like me logo Genes that share disorders with INA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INA Gene

Publications for INA Gene

  1. Cloning and developmental expression of human 66 kd neurofilament protein. (PMID: 7769995) Chan S.-O. … Chiu F.-C. (Brain Res. Mol. Brain Res. 1995) 2 23 67
  2. Loss of astrocytic glutamate transporters in Wernicke encephalopathy. (PMID: 19565658) Hazell A.S. … Wang C. (Glia 2010) 23 67
  3. [Gliomatosis cerebri: a biopsy and autopsy case report]. (PMID: 20223351) San Millan B. … Gray F. (Ann Pathol 2010) 23 67
  4. Dysfunctions of neuronal and glial intermediate filaments in disease. (PMID: 19587456) Liem R.K. … Messing A. (J. Clin. Invest. 2009) 23 67
  5. Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease. (PMID: 19669651) Neumann M. … Mackenzie I.R. (Acta Neuropathol. 2009) 23 67

Products for INA Gene

Sources for INA Gene

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