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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INA Gene

protein-coding   GIFtS: 55
GCID: GC10P105026

internexin neuronal intermediate filament protein, alpha


(Previous symbol: NEF5)
 Explore 47 diseases affiliated with
INA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for INA    

Aliases
for INA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Internexin Neuronal Intermediate Filament Protein, Alpha1 2     Alpha-Internexin1
NEF51 2 3     Neurofilament 5 (66kD)2
NF-661 2 3     Neurofilament-66, Tax-Binding Protein2
66 KDa Neurofilament Protein2 3     Alpha-Inx3
TXBP-12     Neurofilament-663
Alpha-Inx3     Neurofilament 53

External Ids:    HGNC: 60571   Entrez Gene: 91182   Ensembl: ENSG000001487987   OMIM: 6053385   UniProtKB: Q163523   

Export aliases for INA gene to outside databases

Previous GC identifers: GC10P103930 GC10P104270 GC10P105168 GC10P104701 GC10P098669


Summaries
for INA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for INA:
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains.
Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role
in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is
involved in the morphogenesis of neurons. (provided by RefSeq, Jun 2009)

UniProtKB/Swiss-Prot: AINX_HUMAN, Q16352
Function: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of
neurons. It may form an independent structural network without the involvement of other neurofilaments or it may
cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges




Genomic Views
for INA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INA gene promoter:
         GR   NF-1   NF-1/L   GR-beta   CBF-C   GATA-2   CBF-B   CBF-A   GR-alpha   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: INA promoter sequence
   Search SABiosciences Chromatin IP Primers for INA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.33   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q24

INA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INA gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P105026:  view genomic region     (about GC identifiers)

Start:
 105,036,920 bp from pter      End:
 105,050,108 bp from pter
Size:
 13,189 bases      Orientation:
 plus strand

Proteins
for INA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AINX_HUMAN, Q16352 (See protein sequence)
Recommended Name: Alpha-internexin  
Size: 499 amino acids; 55391 Da
Developmental stage: Expressed in brain as early as the 16th week of gestation, and increased rapidly and reached a
steady state level by the 18th week of gestation
Secondary accessions: B1AQK0 Q9BRC5

Explore the universe of human proteins at neXtProt for INA: NX_Q16352

Post-translational modifications:

  • O-glycosylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16352

    • INA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_116116.1  
    ENSEMBL proteins: 
     ENSP00000358865  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: INA
    OriGene Custom Protein Services for INA 
    GenScript Custom Purified and Recombinant Proteins Services for INA
    Novus Biologicals INA Protein
    Novus Biologicals INA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005883neurofilament IEA--


    INA for ontologies           About GeneDecksing



    INA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of INA
    R&D Systems Antibodies for INA (alpha-Internexin)
    OriGene Antibodies (see all 3): INA
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    Abcam antibodies for INA 
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    ThermoFisher Antibody for INA

    Assay Products for INA: 
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for INA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    INA for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR006821 Intermed_filament_DNA-bd
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F

    Graphical View of Domain Structure for InterPro Entry Q16352

    ProtoNet protein and cluster: Q16352

    2 Blocks protein families:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: AINX_HUMAN, Q16352
    Similarity: Belongs to the intermediate filament family


    Function
    for INA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AINX_HUMAN, Q16352
    Function: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of
    neurons. It may form an independent structural network without the involvement of other neurofilaments or it may
    cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges

    miRNA
    Products:            		 OriGene 3'-UTR Clone: INA
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INA
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate INA (see all 23):
    hsa-miR-3164 hsa-miR-448 hsa-miR-642a hsa-miR-1288 hsa-miR-1271 hsa-miR-29c hsa-miR-29a hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmid: INA 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INA (see all 7)
    OriGene shRNA RFP: INA
    OriGene siRNA: INA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for INA

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INA (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INA (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: INA (NM_001085)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INA 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for INA
    Search LifeMap BioReagents cell lines for INA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INA

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005200structural constituent of cytoskeleton TAS7769995


    INA for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for INA:
     Increased cell number in G1, s 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ina):
     nervous system  normal 

    INA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for INA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeleton remodeling Neurofilaments
    		Cytoskeleton remodeling Neurofilaments1.00
    		Cytoskeleton remodeling_Neurofilaments0.91

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for INA
        Cytoskeleton remodeling Neurofilaments


    1 GeneGo (Thomson Reuters) Pathway for INA
        Cytoskeleton remodeling Neurofilaments



    INA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/25 Interacting proteins for INA (Q163523 ENSP000003588654) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIN1Q055863, ENSP000003606164I2D: score=4 STRING: ENSP00000360616
    GRIN2DO153993, ENSP000002632694I2D: score=1 STRING: ENSP00000263269
    TANC1Q9C0D53, ENSP000002636354I2D: score=1 STRING: ENSP00000263635
    STAU1O957933, ENSP000003609224I2D: score=4 STRING: ENSP00000360922
    SQSTM1Q135013I2D: score=3 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--
    GO:0042246tissue regeneration ----
    GO:0045104intermediate filament cytoskeleton organization ----
    GO:0060052neurofilament cytoskeleton organization IEA--


    INA for ontologies           About GeneDecksing



    Drugs & Compounds
    for INA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INA
    3 Novoseek chemical compound relationships for INA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 12.4 2 7609647 (2)
    opiate 10.2 1 14969742 (1)
    calcium 0 1 9482252 (1)

    Search CenterWatch for drugs/clinical trials and news about INA / AINX 

    Transcripts
    for INA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for INA gene: 
    NM_032727.3  

    Unigene Cluster for INA:

    Internexin neuronal intermediate filament protein, alpha
    Hs.500916  [show with all ESTs]
    Unigene Representative Sequence: NM_032727
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369849(uc009xxj.3 uc001kws.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: INA
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INA
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate INA (see all 23):
    hsa-miR-3164 hsa-miR-448 hsa-miR-642a hsa-miR-1288 hsa-miR-1271 hsa-miR-29c hsa-miR-29a hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmid: INA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INA (see all 7)
    OriGene shRNA RFP: INA
    OriGene siRNA: INA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INA
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INA (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INA (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: INA (NM_001085)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INA 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INA
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat INA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INA

    Additional cDNA sequence: 

    AB209785.1 AK293490.1 AK311620.1 BC006359.2 S78296.1 

    8 DOTS entries:

    DT.316335  DT.100803480  DT.97820084  DT.97820643  DT.100809962  DT.95096205  DT.100672227  DT.40266245 

    24/144 AceView cDNA sequences (see all 144):

    BM720667 BE781432 BM676458 AI128642 BX952021 AI039101 AA903936 AI928960 
    AA084642 AL134581 BX281645 N78535 AA206803 Z42524 AA621661 BQ892997 
    CA848830 AA962249 CB132103 CR591335 NM_032727 BM695813 AW157275 AI879375 

    GeneLoc Exon Structure


    Expression
    for INA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTCAATAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    INA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeGanglion Cell LayerMature Ganglion CellsGanglion, Retina
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    EyeRetinaEye
    Gut TubeMidgutGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Matrigel embedded cells (Derivation of cardio...)

    See INA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INA

    SOURCE GeneReport for Unigene cluster: Hs.500916

    UniProtKB/Swiss-Prot: AINX_HUMAN, Q16352
    Tissue specificity: Found predominantly in adult CNS

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INA

    Orthologs
    for INA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for INA gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		possible ortholog
    		 AAWZ02039762(4434-6932)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ina-A2 internexin neuronal intermediate filament protein, more 75.4(n)    U63711.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii gefiltin2 gefiltin 78.29(n)   30230  NM_131032.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea ifp-16
    ifc-26
    (see all 12)    		 Intermediate filament protein ifc-2
    (see all 12)    		 8(a)
    7(a)
    (see all 12)    		 possible ortholog
    possible ortholog
    (see all 12)    		 X(9675786-9680111)
    X(642160-654902)


    ENSEMBL Gene Tree for INA (if available)
    TreeFam Gene Tree for INA (if available) 

    Paralogs
    for INA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INA gene
    LMNB12  SYNM2  VIM2  LMNA2  NES2  PRPH2  DES2  NEFM2  
    LMNB22  NEFH2  GFAP2  
    18/32 SIMAP similar genes for INA using alignment to 1 protein entry:     AINX_HUMAN(see all similar genes):
    GFAP    VIM    DES    tmp_locus_29    NEFM    PRPH
    NEFL    DKFZp761K0922    NEFH    KRT5    KRT75    KRT3
    KRT8    KRT81    KRT83    KRT86    KRT13    KRT16

    INA for paralogs           About GeneDecksing



    Genomic Variants
    for INA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/227 NCBI SNPs in INA are shown (see all 227)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs79069771,2
    		C,--98667296(+) aactcC/Tgtctc 1 -- us2k12Minor allele frequency- T:0.21WA 120
    rs792261011,2
    		--98667555(+) TACCAG/CGTCTT 1 -- us2k12Minor allele frequency- C:0.03CSA WA 120
    rs763040211,2
    		F,--98667833(+) CTGGAA/GTTCTG 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs779318441,2
    		F,--98667893(+) ATCCTG/AAATGA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1131315981,2
    		--98667940(+) CCACAC/ATGACC 1 -- us2k12Minor allele frequency- A:0.02CSA WA 120
    rs800201941,2
    		C,--98668283(+) ATACAA/GATGGC 1 -- us2k13Minor allele frequency- G:0.06NA EA 242
    rs111916291,2
    		C,F,H,--98668380(+) ATCTCC/ATGGTT 1 -- us2k19Minor allele frequency- A:0.17NS NA WA 1014
    rs762870081,2
    		--98669236(+) CTGCCG/TCACCT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs10634551,2
    		H--98669571(+) TCCGCA/TCCAAC 2 T S mis1 ese37Minor allele frequency- T:0.00MN NS EA NA 578
    rs10634571,2
    		H--98670084(+) TGACCT/GCGGCT 2 /A /S mis1 ese35Minor allele frequency- G:0.00MN NS EA 564

    HapMap Linkage Disequilibrium report for INA (105036920 - 105050108 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for INA: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INA
    DNA2.0 Custom Variant and Variant Library Synthesis for INA

    Disorders / Diseases
    for INA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    INA for disorders           About GeneDecksing

    OMIM gene information: 605338    OMIM disorders: --

    20/47 diseases for INA (see all 47):    About MalaCards
    neuronitis    atypical teratoid rhabdoid tumor    gliomatosis cerebri    vertebrobasilar insufficiency
    focal cortical dysplasia    hypothalamic hamartomas    temporal lobe epilepsy    frontotemporal dementia
    retinal microaneurysm    wernicke encephalopathy    motor neuron disease    rhabdoid tumors
    medulloepithelioma    amyotrophic lateral sclerosis    cerebrovascular accident    anaplastic oligodendroglioma
    myotilinopathy    lateral sclerosis    prostate small cell carcinoma    tauopathy

    1 disease from the University of Copenhagen DISEASES database for INA:
    Cerebrovascular accident

    10 Novoseek disease relationships for INA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cmv infection 69.5 11 15170578 (2), 16722980 (1), 15883343 (1), 16005115 (1) (see all 9)
    frontotemporal dementia 66.5 5 15170578 (2), 19669651 (1), 16005115 (1)
    motor neuron disease 58.2 2 15170578 (2)
    tauopathies 55.8 1 15170578 (1)
    neurodegenerative diseases 36 5 15170578 (3), 16911480 (1)
    neurological disorders 28.5 5 15170578 (2), 15161649 (1), 16005115 (1)
    astrocytoma 16.2 1 16598485 (1)
    alzheimers disease 10.8 3 15686957 (2), 15170578 (1)
    shock 0 3 19898260 (1), 15731543 (1), 9482252 (1)
    tumors 0 11 19139367 (2), 18528283 (2), 8078299 (1), 18492260 (1) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: INA (12 documents)

    Export disorders for INA gene to outside databases

    Publications
    for INA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INA gene, integrated from 9 sources (see all 109):
    (articles sorted by number of sources associating them with INA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and developmental expression of human 66 kd neurofilament protein. (PubMed id 7769995)1, 2, 3, 9 Chan S.-O. and Chiu F.-C. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. alpha-Internexin expression identifies 1p19q codeleted gliomas. (PubMed id 19139367)1, 9 Ducray F....Sanson M. (2009)
    4. A comparative immunohistochemical analysis of small round cell tumors of childhood: utility of peripherin and alpha-internexin as markers for neuroblastomas. (PubMed id 18528283)1, 9 Willoughby V....Donner L.R. (2008)
    5. alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease. (PubMed id 15161649)1, 9 Cairns N.J....Trojanowski J.Q. (2004)
    6. Specific interaction of HTLV tax protein and a human type IV neuronal intermediate filament protein. (PubMed id 9435256)1, 9 Reddy T.R....Wong-Staal F. (1998)
    7. Topography of alpha-internexin-positive neuronal aggregates in 10 patients with neuronal intermediate filament inclusion disease. (PubMed id 16722980)1, 9 Armstrong R.A. and Cairns N.J. (2006)
    8. Expression of neuronal and glial polypeptides during histogenesis of the human cerebellar cortex including observations on the dentate nucleus. (PubMed id 7690783)1, 9 Yachnis A.T....Trojanowski J.Q. (1993)
    9. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    10. Genome-wide association analysis identifies susceptibi lity loci for migraine without aura. (PubMed id 22683712)1 Freilinger T....van den Maagdenberg A.M. (2012)

    External Searches for INA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing INA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9118 HGNC: 6057 AceView: INA Ensembl:ENSG00000148798 euGenes: HUgn9118
    ECgene: INA H-InvDB: INA

    Other Databases showing INA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing INA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for INA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for INA gene:
    Search GeneIP for patents involving INA

    GeneCards and IP:
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