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IMPG2 Gene

protein-coding   GIFtS: 50
GCID: GC03M100944

Interphotoreceptor Matrix Proteoglycan 2

  See IMPG2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interphotoreceptor Matrix Proteoglycan 21 2     RP562 5
IPM2002 3 5     SPACRCAN2
Interphotoreceptor Matrix Proteoglycan Of 200 KDa2 3     Interphotoreceptor Matrix Proteoglycan IPM 2002
Sialoprotein Associated With Cones And Rods Proteoglycan2 3     Spacrcan3
IPM 2002 3     

External Ids:    HGNC: 183621   Entrez Gene: 509392   Ensembl: ENSG000000811487   OMIM: 6070565   UniProtKB: Q9BZV33   

Export aliases for IMPG2 gene to outside databases

Previous GC identifers: GC03M097598 GC03M100372 GC03M102226 GC03M102266 GC03M102428 GC03M098313


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IMPG2 Gene:
The protein encoded by this gene binds chondroitin sulfate and hyaluronan and is a proteoglycan. The encoded
protein plays a role in the organization of the interphotoreceptor matrix and may promote the growth and
maintenance of the light-sensitive photoreceptor outer segment. Defects in this gene are a cause of retinitis
pigmentosa type 56 and maculopathy, IMPG2-related.(provided by RefSeq, Mar 2011)

GeneCards Summary for IMPG2 Gene:
IMPG2 (interphotoreceptor matrix proteoglycan 2) is a protein-coding gene. Diseases associated with IMPG2 include maculopathy, impg2-related, and impg2-related retinitis pigmentosa. GO annotations related to this gene include heparin binding and hyaluronic acid binding. An important paralog of this gene is IMPG1.

UniProtKB/Swiss-Prot: IMPG2_HUMAN, Q9BZV3
Function: Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of
interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor
outer segment. Binds heparin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the IMPG2 gene promoter:
         Oct-B1   E2F-3a   E2F-4   E2F-5   oct-B2   E2F-2   E2F   E2F-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIMPG2 promoter sequence
   Search Chromatin IP Primers for IMPG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IMPG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.2-q12.3   Ensembl cytogenetic band:  3q12.3   HGNC cytogenetic band: 3q12.2-q12.3

IMPG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IMPG2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M100944:  view genomic region     (about GC identifiers)

Start:
100,941,390 bp from pter      End:
101,039,419 bp from pter
Size:
98,030 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IMPG2_HUMAN, Q9BZV3 (See protein sequence)
Recommended Name: Interphotoreceptor matrix proteoglycan 2 precursor  
Size: 1241 amino acids; 138621 Da
Secondary accessions: A8MWT5 Q9UKD4 Q9UKK5

Explore the universe of human proteins at neXtProt for IMPG2: NX_Q9BZV3

Explore proteomics data for IMPG2 at MOPED

Post-translational modifications: 

  • Highly glycosylated (N- and O-linked carbohydrates)1
  • Glycosylation2 at Asn154, Thr190, Thr192, Asn301, Asn320, Asn370, Thr544, Thr556, Asn942, Asn956

  • See IMPG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057331.2  
    ENSEMBL proteins: 
     ENSP00000193391  

    IMPG2 Human Recombinant Protein Products:

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    Novus Biologicals IMPG2 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IMPG2

     
    Search eBioscience for Proteins for IMPG2 

     
    antibodies-online proteins for IMPG2 (2 products) 

     
    antibodies-online peptides for IMPG2

    IMPG2 Antibody Products:

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    Search ThermoFisher Antibodies for IMPG2
    antibodies-online antibodies for IMPG2 (4 products) 

    IMPG2 Assay Products:

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    Cloud-Clone Corp. ELISAs for IMPG2
    Cloud-Clone Corp. CLIAs for IMPG2
    Search eBioscience for ELISAs for IMPG2 
    antibodies-online kits for IMPG2 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR000082 SEA_dom
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry Q9BZV3

    ProtoNet protein and cluster: Q9BZV3

    1 Blocks protein domain: IPB000082 SEA domain

    UniProtKB/Swiss-Prot: IMPG2_HUMAN, Q9BZV3
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 2 SEA domains


    Find genes that share domains with IMPG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IMPG2_HUMAN, Q9BZV3
    Function: Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of
    interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor
    outer segment. Binds heparin

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent TAS10702256
    GO:0005515protein binding ----
    GO:0005540hyaluronic acid binding TAS10702256
    GO:0008201heparin binding IEA--
         
    Find genes that share ontologies with IMPG2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IMPG2:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IMPG2

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate IMPG2 (see all 52):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-136 hsa-let-7d hsa-miR-488 hsa-miR-570 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidIMPG2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IMPG2

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    GenScript: all cDNA clones in your preferred vector: IMPG2 (NM_016247)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMPG2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IMPG2_HUMAN, Q9BZV3: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix TAS10702256
    GO:0016021integral component of membrane IEA--
    GO:0043235receptor complex IDA--

    Find genes that share ontologies with IMPG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IMPG2 About    
    See pathways by source

    SuperPathContained pathways About
    1Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    PTEN Pathway0.56

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IMPG2 (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IMPG2
    Interactions:

        Search GeneGlobe Interaction Network for IMPG2

    1 Interacting protein for IMPG2 (Q9BZV33) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CAP677753I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007601visual perception TAS10702256

    Find genes that share ontologies with IMPG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IMPG2

    1 HMDB Compound for IMPG2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronanhyaluronic acid (see all 13)9004-61-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IMPG2 gene: 
    NM_016247.3  

    Unigene Cluster for IMPG2:

    Interphotoreceptor matrix proteoglycan 2
    Hs.209249  [show with all ESTs]
    Unigene Representative Sequence: NM_016247
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000193391(uc011bhe.2 uc003duq.2 uc010hpj.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat IMPG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IMPG2 (see all 52):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-136 hsa-let-7d hsa-miR-488 hsa-miR-570 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidIMPG2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IMPG2
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    OriGene ORF clones in mouse, rat for IMPG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IMPG2 (NM_016247)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IMPG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMPG2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IMPG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IMPG2
      QuantiTect SYBR Green Assays in human, mouse, rat IMPG2
      QuantiFast Probe-based Assays in human, mouse, rat IMPG2

    Additional mRNA sequence: 

    AB593127.1 AF157624.1 AF173155.1 AF319972.1 BC144092.1 

    5 DOTS entries:

    DT.101955084  DT.97839976  DT.95189990  DT.425499  DT.100739143 

    Selected AceView cDNA sequences (see all 35):

    BX953412 BM799621 BX510203 AA744481 AF157624 AF319972 BX954997 BX953550 
    AA364834 BX953286 BM929973 AA721009 AL712421 BU167472 NM_016247 BX283908 
    BX953290 AA815118 BX491222 AF173155 AL713046 AA736980 BX642541 BX509854 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IMPG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAGTCTG
    IMPG2 Expression
    About this image

    IMPG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IMPG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.209249

    UniProtKB/Swiss-Prot: IMPG2_HUMAN, Q9BZV3
    Tissue specificity: Expressed in the retina. Expressed by photoreceptors of the interphotoreceptor matrix (IPM)
    surrounding both rods and cones. IPM occupies the subretinal space between the apices of the retinal pigment
    epithelium and the neural retina. Detected in the pineal gland

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IMPG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IMPG2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Impg21 , 5 interphotoreceptor matrix proteoglycan 21, 5 81.52(n)1
    72.73(a)1
      16 (33.91 cM)5
    2242241  NM_174876.31  NP_777365.21 
     562043135 
    chicken
    (Gallus gallus)
    Aves IMPG21 interphotoreceptor matrix proteoglycan 2 63.39(n)
    54.38(a)
      418393  NM_001044639.1  NP_001038104.1 
    lizard
    (Anolis carolinensis)
    Reptilia IMPG26
    interphotoreceptor matrix proteoglycan 2
    44(a)
    1 ↔ 1
    3(173699472-173771539)
    zebrafish
    (Danio rerio)
    Actinopterygii IMPG2 (4 of 4)6
    IMPG2 (1 of 4)6
    (see all 4)
    interphotoreceptor matrix proteoglycan 2
    (see all 4)
    66(a)
    38(a)
    (see all 4)
    many → 1
    many → 1
    (see all 4)
    22(30302867-30339587) ENSDARG00000094099
    9(31213330-31226051) ENSDARG00000019782


    ENSEMBL Gene Tree for IMPG2 (if available)
    TreeFam Gene Tree for IMPG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IMPG2 gene
    IMPG12  
    1 SIMAP similar gene for IMPG2 using alignment to 3 protein entries:     IMPG2_HUMAN (see all proteins):
    DKFZp686K0887

    Find genes that share paralogs with IMPG2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IMPG2 (see all 1922)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0643364
    Maculopathy, IMPG2-related (MACLP-IMPG2)4--see VAR_0643362 F L mis40--------
    rs2018935451,2
    Cpathogenic1100990410(+) CCAAAA/GAGTCC 2 L F mis10--------
    rs729324681,2
    C,F--98352665(+) TTGTAT/CGGAAC 1 -- int12Minor allele frequency- C:0.03WA 120
    rs3776335821,2
    C--98398029(+) GTCTC-/AAAAAAA
    AAAAAAAAA
    AAAAA
    1 -- int10--------
    rs2000399611,2
    C--98399480(+) TATAC-/AAAAAA 1 -- int10--------
    rs360909401,2
    C--98404553(+) GGTGG-/GCATT 
    ATAAATGG
    TCATG
    1 -- int11Minor allele frequency- GCATTATAAATGG:0.00NA 2
    rs105405431,2
    C--98407612(+) AATAA-/AGTAGTAT 1 -- int10--------
    rs1895105011,2
    C--98407613(+) ATAAAA/G/TTAGTA 1 -- int10--------
    rs1918329911,2
    --100908300(+) TGTTTA/TTTTCT 1 -- ds50010--------
    rs1167137081,2
    C,F--100908302(+) TTTATT/GTCTTC 1 -- ds50011Minor allele frequency- G:0.04WA 118

    HapMap Linkage Disequilibrium report for IMPG2 (100941390 - 101039419 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IMPG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508232CNV Loss20534489
    nsv877222CNV Gain21882294

    Human Gene Mutation Database (HGMD): IMPG2
    Locus Specific Mutation Databases (LSDB): IMPG2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IMPG2
    DNA2.0 Custom Variant and Variant Library Synthesis for IMPG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607056   
    OMIM disorders: 613581  
    UniProtKB/Swiss-Prot: IMPG2_HUMAN, Q9BZV3
  • Retinitis pigmentosa 56 (RP56) [MIM:613581]: A retinal dystrophy belonging to the group of pigmentary
    retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination
    and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically
    have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose
    their far peripheral visual field and eventually central vision as well. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Maculopathy, IMPG2-related (MACLP-IMPG2) [MIM:613581]: A mild maculopathy characterized by full-field
    electroretinogram responses within normal limits, normal color vision, elevation of the photoreceptor layer in
    the foveal region and mild nuclear sclerosis. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 4 diseases for IMPG2:    
    About MalaCards
    maculopathy, impg2-related    impg2-related retinitis pigmentosa    retinitis pigmentosa 56    leber congenital amaurosis


    Find genes that share disorders with IMPG2           About GenesLikeMe

    Genetic Association Database (GAD): IMPG2
    Human Genome Epidemiology (HuGE) Navigator: IMPG2 (1 document)

    Export disorders for IMPG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IMPG2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with IMPG2)
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    world of online information

    1. Molecular characterization and genomic mapping of human IPM 200, a second member of a novel family of proteoglycans. (PubMed id 10542133)1, 2, 3 Kuehn M.H. and Hageman G.S. (Mol. Cell Biol. Res. Commun. 1999)
    2. SPACRCAN, a novel human interphotoreceptor matrix hyaluronan-binding proteoglycan synthesized by photoreceptors and pinealocytes. (PubMed id 10702256)1, 2, 9 Acharya S.... Hollyfield J.G. (J. Biol. Chem. 2000)
    3. Organization of the human IMPG2 gene and its evaluation as a candidate gene in age-related macular degeneration and other retinal degenerative disorders. (PubMed id 11726612)1, 2, 9 Kuehn M.H.... Hageman G.S. (Invest. Ophthalmol. Vis. Sci. 2001)
    4. Mutations in IMPG2, encoding interphotoreceptor matrix proteoglycan 2, cause autosomal-recessive retinitis pigmentosa. (PubMed id 20673862)1, 2 Bandah-Rozenfeld D....den Hollander A.I. (Am. J. Hum. Genet. 2010)
    5. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (Invest. Ophthalmol. Vis. Sci. 2011)
    6. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    9. Retinitis Pigmentosa Overview (PubMed id 20301590)1 Pagon R.A....Stephens K. (1993)
    10. SPACRCAN in the interphotoreceptor matrix of the mouse retina: molecular, developmental and promoter analysis. (PubMed id 12589770)9 Chen Q....Hollyfield J.G. (Exp. Eye Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50939 HGNC: 18362 AceView: IMPG2 Ensembl:ENSG00000081148 euGenes: HUgn50939
    ECgene: IMPG2 H-InvDB: IMPG2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IMPG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IMPG2 gene:
    Search GeneIP for patents involving IMPG2

    GeneCards and IP:
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