IMPDH2 Gene
protein-coding GIFtS: 66
GCID: GC03M049061
|
|
IMP (inosine 5'-monophosphate) dehydrogenase 2
| |
Aliases
for IMPDH2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| IMP (Inosine 5'-Monophosphate) Dehydrogenase 21 2 | | IMP (Inosine Monophosphate) Dehydrogenase 22 | | IMPD22 3 5 | | IMP Oxireductase 22 | | IMPDH-II2 3 | | Inosine 5' Phosphate Dehydrogenase 22 | | IMPD 22 3 | | Inosine Monophosphate Dehydrogenase Type II2 | | IMPDH 22 3 | | Inosine-5'-Monophosphate Dehydrogenase 22 | | EC 1.1.1.2053 8 | | IMP Dehydrogenase 23 |
Export aliases for IMPDH2 gene to outside databasesPrevious GC identifers: GC03U990046 GC03M048208 GC03M048916 GC03M049020 GC03M049036 |
Summaries
for IMPDH2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IMPDH2:
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved inmaintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded proteincatalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is thenconverted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a rolein malignant transformation. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268Function: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committedand rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in theregulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role inRNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of sometumors
Gene Wiki entry for IMPDH2
|
Genomic Views
for IMPDH2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IMPDH2 gene promoter:
POU2F2C E2F-3a E2F-4 E2F E2F-1 E2F-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for IMPDH2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IMPDH2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.2 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.2IMPDH2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M049061: view genomic region
(about GC identifiers)
Start:
|
49,061,758 bp from pter |
End:
|
49,066,875 bp from pter |
Size:
|
5,118 bases |
Orientation:
|
minus strand |
|
Proteins
for IMPDH2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268 (See
protein sequence)Recommended Name: Inosine-5'-monophosphate dehydrogenase 2 Size: 514 amino acids; 55805 Da
Cofactor: Potassium
Subunit: Homotetramer
Subcellular location: Cytoplasm. Nucleus
Miscellaneous: Because IMPDH activity is tightly linked with cell proliferation, it has been recognized as a target forcancer and viral chemotherapy and as a target for immunosuppressive drugs. The activities of the antitumor drugtiazofurin, the antiviral drug ribavirin, and the immunosuppressive drugs mizoribine and mycophenolic acid (MPA) areattributed to the inhibition of IMPDH. In addition, bacterial and parasitic IMPDH's differ significantly frommammalian enzymes, which makes it a suitable target for anti-infective drugs
3 PDB 3D structures from  and Proteopedia  for IMPDH2:1B3O (3D)
1NF7 (3D)
1NFB (3D)
Secondary accessions: Q6LEF3Explore the universe of human proteins at neXtProt for IMPDH2: NX_P12268
Post-translational modifications:
The N-terminus is blocked1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P12268
4/24 DME Specific Peptides for IMPDH2 (P12268) (see all 24)
IMPDH2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000875.2
ENSEMBL proteins: ENSP00000393525 ENSP00000321584 ENSP00000403502 Reactome Protein details: P12268
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
IMPDH2 for ontologies About GeneDecksing
IMPDH2 Antibody Products:
Assay Products for IMPDH2: |
Protein
Domains /
Families
for IMPDH2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IMPDH2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P12268ProtoNet protein and cluster: P12268 2 Blocks protein families: IPB000644 CBS domain IPB001093 IMP dehydrogenase/GMP reductase
UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268Similarity: Belongs to the IMPDH/GMPR familySimilarity: Contains 2 CBS domains |
Function
for IMPDH2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268Function: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committedand rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in theregulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role inRNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of sometumorsCatalytic activity: Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADHEnzyme regulation: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzymeconformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is acompetitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poorinhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. Subject to product inhibitionby XMP and NADH. Also inhibited by ADPBiophysicochemical properties: Kinetic parameters: KM=9.3 uM for Inosine 5'-phosphate; KM=32 uM for NAD(+);Induction: Selectively up-regulated in neoplastic and replicating cells Genatlas biochemistry entry for IMPDH2:inosine 5'-monophosphate dehydrogenase,type II,paralog to IMPDH1
Enzyme Number (IUBMB): EC 1.1.1.2051 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IMPDH2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IMPDH2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IMPDH2 (NM_000884) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IMPDH2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMPDH2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IMPDH2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
IMPDH2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Impdh2tm1Bmi for IMPDH2
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Impdh2):
IMPDH2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for IMPDH2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Purine metabolism | | | 2 | purine nucleotides de novo biosynthesis II | | | 3 | Metabolism | | | 4 | purine nucleotides degradation II (aerobic) | | | 5 | Purine metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3  BioSystems Pathways for IMPDH2
4 
Reactome Pathways for IMPDH2
1  PharmGKB Pathway for IMPDH2
3 
Kegg Pathways (Kegg details for IMPDH2):
UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268Pathway: Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1
IMPDH2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IMPDH2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/99 Interacting proteins for IMPDH2 (P122682, 3 ENSP000003215844) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006144 | purine nucleobase metabolic process |
TAS | -- | | GO:0006164 | purine nucleotide biosynthetic process |
-- | -- | | GO:0006177 | GMP biosynthetic process |
IEA | -- | | GO:0009168 | purine ribonucleoside monophosphate biosynthetic process |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
IMPDH2 for ontologies About GeneDecksing
|
Drugs & Compounds
for IMPDH2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
IMPDH2 for compounds About GeneDecksing
 Browse Tocris compounds for IMPDH2
6 HMDB Compounds for IMPDH2 About this table
8 DrugBank Compounds for IMPDH2 About this table
7 Novoseek chemical compound relationships for IMPDH2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inosine monophosphate |
95.6 |
52 |
17496727 (3), 7707313 (3), 16647299 (2), 18976158 (2) (see all 28) |
| xanthosine-5'-monophosphate |
87.4 |
2 |
7906542 (1) |
| mycophenolic acid |
84.8 |
17 |
19299544 (2), 19770842 (2), 15614187 (1), 7600680 (1) (see all 9) |
| purine |
59.9 |
4 |
17496727 (1), 16647299 (1), 15621150 (1) |
| mycophenolate mofetil |
57.1 |
5 |
12193749 (1), 15252268 (1), 15621150 (1), 17805303 (1) |
| methotrexate |
21.3 |
6 |
16609701 (3), 15614187 (1), 15670151 (1) |
| hydrogen |
0 |
1 |
9434751 (1) |
Search CenterWatch for drugs/clinical trials and news about IMPDH2 / IMDH2
|
Transcripts
for IMPDH2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IMPDH2 gene: NM_000884.2 Unigene Cluster for IMPDH2: IMP (inosine 5'-monophosphate) dehydrogenase 2 Hs.654400 [show with all ESTs]Unigene Representative Sequence: AK29339712 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000472328 ENST00000466147 ENST00000429182 ENST00000326739(uc003cvt.3)
ENST00000463903 ENST00000484872 ENST00000481274 ENST00000462980 ENST00000442157
ENST00000491610 ENST00000485500 ENST00000496837
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IMPDH2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IMPDH2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IMPDH2 (NM_000884) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IMPDH2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMPDH2 |
Additional cDNA sequence: AF075074.1 AK293397.1 AY545560.1 BC006124.1 BC009236.2 BC012840.1 BC015567.2 J04208.1 24/37 DOTS entries (see all 37): DT.100671256 DT.449997 DT.100045605 DT.100769128 DT.100671233 DT.100045602 DT.95250877 DT.100671235 DT.95250897 DT.100671239 DT.102838814 DT.100671243 DT.427613 DT.95250899 DT.120910354 DT.424101 DT.92469759 DT.100866768 DT.121643111 DT.92469756 DT.100671245 DT.100858086 DT.120910380 DT.120910392 24/1197 AceView cDNA sequences (see all 1197): BM461598 BM810527 CA422217 BM927655 BM909186 BM743753 BE740038 BE304335 BI334776 BX383894 BE409362 BG766209 BM810528 BC015567 BU189137 BM740653 BQ943162 BU170490 BU677607 BU155005 BF797477 BM810431 BQ641754 BM423394
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for IMPDH2 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 15 |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for IMPDH2
|
Expression
for IMPDH2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IMPDH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGTACTCTG
About this image
See IMPDH2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IMPDH2
SOURCE GeneReport for Unigene cluster: Hs.654400
UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268Tissue specificity: IMP type I is the main species in normal leukocytes and type II predominates over type I in thetumor
SABiosciences Custom PCR Arrays for IMPDH2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IMPDH2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IMPDH2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IMPDH2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IMPDH2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IMPDH2 |
Orthologs
for IMPDH2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for IMPDH2 gene from 9/39 species (see all 39) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
IMPDH21 |
IMP (inosine 5'-monophosphate) dehydrogenase 2 |
80.35(n)
94.94(a) |
|
416058 NM_001030601.1 NP_001025772.1 |
lizard
(Anolis carolinensis) |
Reptilia |
IMPDH26 |
-- |
88(a) |
1 ↔ 1 |
2(187890460-187924741) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC042315.12 |
-- |
77.22(n) |
|
BC042315.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.26362 |
Danio rerio mRNA similar to IMP (inosine monophosphate) more |
78.83(n) |
|
BC046905.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
ras3 |
GMP biosynthesis IMP dehydrogenase |
68(a) |
|
9E2 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
T22D1.36 |
Inosine-5'-monophosphate dehydrogenase |
52(a) |
1 → many |
IV(6913523-6917105) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G163506AT1G794706 |
inosine-5'-monophosphate dehydrogenase |
48(a)47(a) |
many ↔ manymany ↔ many |
1(5590951-5593007) 1(29894598-29897166) |
rice
(Oryza sativa) |
Liliopsida |
Os.47382 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
75.57(n) |
|
AK065289.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
guaB6 |
IMP dehydrogenase |
40(a) |
possible ortholog |
Chromosome(2630626-2632092) |
ENSEMBL Gene Tree for IMPDH2 (if available)
TreeFam Gene Tree for IMPDH2 (if available) |
Paralogs
for IMPDH2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IMPDH2 gene
- GMPR22 IMPDH12 GMPR2
4 SIMAP similar genes for IMPDH2 using alignment to 6 protein entries: IMDH2_HUMAN (see all proteins):DKFZp781N0678 IMPDH IMPDH1 GMPR2
IMPDH2 for paralogs About GeneDecksing
|
Genomic Variants
for IMPDH2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IMPDH2 (49061758 - 49066875 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IMPDH2: --
Human Gene Mutation Database (HGMD): IMPDH2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IMPDH2 |
|
Disorders
/ Diseases
for IMPDH2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IMPDH2 for disorders About GeneDecksing
OMIM gene information: 146691
OMIM disorders: --
20  diseases for IMPDH2: About MalaCardsretinitis pigmentosa glanders diabetes mellitus down syndrome
multiple sclerosis huntington's disease neurodegeneration retinitis
colon cancer gastric cancer colorectal cancer osteosarcoma
ataxia pneumonia neuroblastoma schizophrenia
tuberculosis melanoma malaria mycobacterium tuberculosis
3 Novoseek disease relationships for IMPDH2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: IMPDH2 (13 documents)
Export disorders for IMPDH2 gene to outside databases
|
Publications
for IMPDH2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IMPDH2 gene, integrated from 9 sources (see all 121):
(articles sorted by number of sources associating them with IMPDH2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Two distinct cDNAs for human IMP dehydrogenase. (PubMed id 1969416)1, 2, 3 Natsumeda Y.... Suzuki K. (1990)
- An exploratory study on pharmacogenetics of inosine-monophosphate dehydrogenase II in peripheral mononuclear cells from liver-transplant recipients. (PubMed id 15621150)1, 7, 9 Vannozzi F....Del Tacca M. (2004)
- A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity. (PubMed id 17496727)1, 7, 9 Wang J....Burckart G.J. (2007)
- Chromosomal localization and structure of the human type II IMP dehydrogenase gene. (PubMed id 8098009)1, 2, 9 Glesne D.A.... Huberman E. (1993)
- Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design. (PubMed id 10097070)1, 2, 9 Colby T.D....Goldstein B.M. (1999)
- Assignment1 of inosine '-monophosphate dehydrogenase type 2 (IMPDH2) to human chromosome band 3p21.2 by in situ hybridization. (PubMed id 9858805)1, 3, 9 Kost-Alimova M.V....Zelenin A.V. (1998)
- Characterization of the human inosine-5'-monophosphate dehydrogenase type II gene. (PubMed id 7896827)1, 2, 9 Zimmermann A.G.... Mitchell B.S. (1995)
- Cloning and sequence of the human type II IMP dehydrogenase gene. (PubMed id 7999076)1, 2, 9 Glesne D.A. and Huberman E. (1994)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo. (PubMed id 14766016)1, 2 McLean J.E....Hedstrom L. (2004)
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External Searches for IMPDH2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing IMPDH2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing IMPDH2 gene
(According to HUGE)
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Specialized Databases showing IMPDH2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for IMPDH2 gene:
Search GeneIP for patents involving IMPDH2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for IMPDH2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for IMPDH2 | | OriGene shRNA RFP for IMPDH2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IMPDH2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IMPDH2 | | | OriGene Protein Over-expression Lysate for IMPDH2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IMPDH2 | | OriGene 3'-UTR Clone for IMPDH2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IMPDH2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IMPDH2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IMPDH2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IMPDH2 | | OriGene Custom Protein Services for IMPDH2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IMPDH2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IMPDH2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IMPDH2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IMPDH2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IMPDH2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IMPDH2 |
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| | | | Search Tocris compounds for IMPDH2 |
| |  |  |  |  | | | | | | Recombinant Protein for IMPDH2 |
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 | | | IMPDH2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IMPDH2 |
|  |  |  | | | | ThermoFisher Antibodies for IMPDH2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMPDH2 |
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