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IMPDH2 Gene

protein-coding   GIFtS: 71
GCID: GC03M049061

IMP (Inosine 5'-Monophosphate) Dehydrogenase 2

  Search for IMPDH2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IMP (Inosine 5'-Monophosphate) Dehydrogenase 21 2     IMP (Inosine Monophosphate) Dehydrogenase 22
IMPD22 3 5     IMP Oxireductase 22
IMPDH-II2 3     Inosine 5' Phosphate Dehydrogenase 22
IMPD 22 3     Inosine Monophosphate Dehydrogenase Type II2
IMPDH 22 3     Inosine-5'-Monophosphate Dehydrogenase 22
EC 1.1.1.2053 8     IMP Dehydrogenase 23

External Ids:    HGNC: 60531   Entrez Gene: 36152   Ensembl: ENSG000001780357   OMIM: 1466915   UniProtKB: P122683   

Export aliases for IMPDH2 gene to outside databases

Previous GC identifers: GC03U990046 GC03M048208 GC03M048916 GC03M049020 GC03M049036


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IMPDH2 Gene:
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in
maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded
protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which
is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may
play a role in malignant transformation. (provided by RefSeq, Jul 2008)

GeneCards Summary for IMPDH2 Gene:
IMPDH2 (IMP (inosine 5'-monophosphate) dehydrogenase 2) is a protein-coding gene. GO annotations related to this gene include RNA binding and adenyl nucleotide binding. An important paralog of this gene is IMPDH1.

UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268
Function: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first
committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an
important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity
and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and
the growth progression of some tumors

Gene Wiki entry for IMPDH2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IMPDH2 gene promoter:
         POU2F2C   E2F-3a   E2F-4   E2F   E2F-1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIMPDH2 promoter sequence
   Search Chromatin IP Primers for IMPDH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IMPDH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.2   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.2

IMPDH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IMPDH2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049061:  view genomic region     (about GC identifiers)

Start:
49,061,758 bp from pter      End:
49,066,875 bp from pter
Size:
5,118 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268 (See protein sequence)
Recommended Name: Inosine-5'-monophosphate dehydrogenase 2  
Size: 514 amino acids; 55805 Da
Cofactor: Potassium
Subunit: Homotetramer
Miscellaneous: Because IMPDH activity is tightly linked with cell proliferation, it has been recognized as a
target for cancer and viral chemotherapy and as a target for immunosuppressive drugs. The activities of the
antitumor drug tiazofurin, the antiviral drug ribavirin, and the immunosuppressive drugs mizoribine and
mycophenolic acid (MPA) are attributed to the inhibition of IMPDH. In addition, bacterial and parasitic IMPDH's
differ significantly from mammalian enzymes, which makes it a suitable target for anti-infective drugs
3 PDB 3D structures from and Proteopedia for IMPDH2:
1B3O (3D)        1NF7 (3D)        1NFB (3D)    
Secondary accessions: Q6LEF3

Explore the universe of human proteins at neXtProt for IMPDH2: NX_P12268

Explore proteomics data for IMPDH2 at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Ubiquitination2 at Lys109, Lys124, Lys134, Lys195, Lys208, Lys293, Lys311, Lys349, Lys422, Lys450,
                                 Lys455, Lys474, Lys489
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for IMPDH2 (P12268) (see all 24)
     YRGMGSL  SKKGKLP  VAQGVSG  GLTYNDF 


    See IMPDH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000875.2  
    ENSEMBL proteins: 
     ENSP00000393525   ENSP00000321584   ENSP00000403502  
    Reactome Protein details: P12268

    IMPDH2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for IMPDH2

     
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    Search eBioscience for ELISAs for IMPDH2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR000644 CBS_dom
     IPR005990 IMP_DH
     IPR001093 IMP_DH_GMPRt
     IPR015875 IMP_DH/GMP_Rdtase_CS

    Graphical View of Domain Structure for InterPro Entry P12268

    ProtoNet protein and cluster: P12268

    2 Blocks protein domains:
    IPB000644 CBS domain
    IPB001093 IMP dehydrogenase/GMP reductase


    UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268
    Similarity: Belongs to the IMPDH/GMPR family
    Similarity: Contains 2 CBS domains


    Find genes that share domains with IMPDH2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IMDH2_HUMAN, P12268
    Function: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first
    committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an
    important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity
    and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and
    the growth progression of some tumors
    Catalytic activity: Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
    Enzyme regulation: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed
    enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP)
    is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs
    but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. Subject to
    product inhibition by XMP and NADH. Also inhibited by ADP
    Biophysicochemical properties: Kinetic parameters: KM=9.3 uM for Inosine 5'-phosphate; KM=32 uM for NAD(+);
    Induction: Selectively up-regulated in neoplastic and replicating cells

         Genatlas biochemistry entry for IMPDH2:
    inosine 5'-monophosphate dehydrogenase,type II,paralog to IMPDH1

         Enzyme Number (IUBMB): EC 1.1.1.2051 2

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IDA14766016
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IEA--
    GO:0003824catalytic activity ----
    GO:0003938IMP dehydrogenase activity IEA--
         
    Find genes that share ontologies with IMPDH2           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Impdh2):
     cellular  hematopoietic system  immune system  mortality/aging 

    Find genes that share phenotypes with IMPDH2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Impdh2tm1Bmi for IMPDH2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IMPDH2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IMPDH2

    miRNA
    Products:
        
    miRTarBase miRNAs that target IMPDH2:
    hsa-mir-23b-3p (MIRT046295), hsa-mir-17-3p (MIRT050763), hsa-mir-16-5p (MIRT031800), hsa-mir-615-3p (MIRT039630), hsa-mir-30b-5p (MIRT046109), hsa-mir-34a-5p (MIRT006255), hsa-let-7b-5p (MIRT032398), hsa-mir-33b-5p (MIRT039581), hsa-mir-324-3p (MIRT042838), hsa-mir-378a-5p (MIRT043988), hsa-mir-23a-3p (MIRT050406)

    Block miRNA regulation of human, mouse, rat IMPDH2 using miScript Target Protectors
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    Sino Biological Human cDNA Clone for IMPDH2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IMPDH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IMDH2_HUMAN, P12268: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    peroxisome5
    cytosol4
    mitochondrion2
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA14766016
    GO:0005737cytoplasm IDA14766016
    GO:0005778peroxisomal membrane IDA--
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with IMPDH2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IMPDH2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (REACTOME)
    Purine metabolism0.42
    purine nucleotides degradation0.00
    Metabolism of nucleotides0.42
    urate biosynthesis/inosine 5-phosphate degradation0.00
    Purine ribonucleoside monophosphate biosynthesis0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3purine nucleotide salvage
    purine nucleotide salvage0.78
    guanosine nucleotides de novo biosynthesis0.00
    purine nucleotides de novo biosynthesis0.78
    guanosine ribonucleotides de novo biosynthesis0.00
    4Irinotecan Pathway, Pharmacokinetics
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics0.50
    5Purine metabolism (KEGG)
    Purine metabolism0.38


    Find genes that share SuperPaths with IMPDH2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for IMPDH2 (see all 6)
        purine nucleotides de novo biosynthesis
    guanosine nucleotides de novo biosynthesis
    purine nucleotide salvage
    urate biosynthesis/inosine 5-phosphate degradation
    purine nucleotides degradation


    1 Reactome Pathway for IMPDH2
        Purine ribonucleoside monophosphate biosynthesis

    1 PharmGKB Pathway for IMPDH2
        Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics

    3 Kegg Pathways  (Kegg details for IMPDH2):
        Purine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways

    UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268
    Pathway: Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IMPDH2
    Interactions:

        Search GeneGlobe Interaction Network for IMPDH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IMPDH2 (P122682, 3 ENSP000003215844) via UniProtKB, MINT, STRING, and/or I2D (see all 212)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206435P305043I2D: score=1 
    ENSG00000206452P305043I2D: score=1 
    HLA-CP305043I2D: score=1 
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2860079 I2D: score=3 STRING: ENSP00000357292
    PIAS4Q8N2W92, 3, ENSP000002629714MINT-3980557 I2D: score=3 STRING: ENSP00000262971
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006051N-acetylmannosamine metabolic process ----
    GO:0006144purine nucleobase metabolic process TAS--
    GO:0006164purine nucleotide biosynthetic process ----
    GO:0006177GMP biosynthetic process IEA--
    GO:0009168purine ribonucleoside monophosphate biosynthetic process TAS--

    Find genes that share ontologies with IMPDH2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IMPDH2 (IMDH2)

    6 HMDB Compounds for IMPDH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Inosinic acid5'-IMP (see all 9)131-99-7--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    PotassiumK+ (see all 16)7440-09-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Xanthylic acid(9-D-ribosylxanthine)-5'-phosphate (see all 7)523-98-8--

    8 DrugBank Compounds for IMPDH2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Mycophenolic acid-- 24280-93-1targetinhibitor17496727 11752352 15621150 16647299 10592235 16629948 15614187
    Inosinic Acid-- 131-99-7target--17139284 17016423 10592235
    Mycophenolate mofetilMMF (see all 4)128794-94-5targetinhibitor17463174 11752352 15621150
    6-Chloropurine Riboside, 5'-Monophosphate-- --target--17139284 17016423
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423
    Ribavirin Monophosphate-- 40925-28-8target--17139284 17016423
    Selenazole-4-Carboxyamide-Adenine Dinucleotide-- --target--17139284 17016423
    NADHbeta-DPNH (see all 18)606-68-8target--17496727

    7 Novoseek inferred chemical compound relationships for IMPDH2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inosine monophosphate 95.6 52 17496727 (3), 7707313 (3), 16647299 (2), 18976158 (2) (see all 28)
    xanthosine-5'-monophosphate 87.4 2 7906542 (1)
    mycophenolic acid 84.8 17 19299544 (2), 19770842 (2), 15614187 (1), 7600680 (1) (see all 9)
    purine 59.9 4 17496727 (1), 16647299 (1), 15621150 (1)
    mycophenolate mofetil 57.1 5 12193749 (1), 15252268 (1), 15621150 (1), 17805303 (1)
    methotrexate 21.3 6 16609701 (3), 15614187 (1), 15670151 (1)
    hydrogen 0 1 9434751 (1)

    3 PharmGKB related drug/compound annotations for IMPDH2 gene    About this table
    Drug/compound PharmGKB Annotation
    cyclosporineCA  
    mycophenolate mofetilCA  
    mycophenolic acidCA  



    Find genes that share compounds with IMPDH2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IMPDH2 gene: 
    NM_000884.2  

    Unigene Cluster for IMPDH2:

    IMP (inosine 5'-monophosphate) dehydrogenase 2
    Hs.654400  [show with all ESTs]
    Unigene Representative Sequence: AK293397
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472328 ENST00000466147 ENST00000429182 ENST00000326739(uc003cvt.3)
    ENST00000463903 ENST00000484872 ENST00000481274 ENST00000462980 ENST00000442157
    ENST00000491610 ENST00000485500 ENST00000496837
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    Additional mRNA sequence: 

    AF075074.1 AK293397.1 AY545560.1 BC006124.1 BC009236.2 BC012840.1 BC015567.2 J04208.1 

    Selected DOTS entries (see all 37):

    DT.100671256  DT.449997  DT.100045605  DT.100769128  DT.100671233  DT.100045602  DT.95250877  DT.100671235 
    DT.95250897  DT.100671239  DT.102838814  DT.100671243  DT.427613  DT.95250899  DT.120910354  DT.424101 
    DT.92469759  DT.100866768  DT.121643111  DT.92469756  DT.100671245  DT.100858086  DT.120910380  DT.120910392 

    Selected AceView cDNA sequences (see all 1197):

    BF797477 BQ687944 AL542763 BQ669958 BE734311 BQ668825 BE279890 BQ950072 
    BU856343 BU540543 BQ226900 BU856873 BQ941627 BU151534 BM552658 AA722433 
    C21495 BX460210 BM810527 BM739180 BI824466 BU740154 BM452548 BM810336 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IMPDH2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
    SP1:                          -                                                                                               -                                 
    SP2:                          -                                   -                                                                                             
    SP3:                          -                                                                                                                                 
    SP4:                                                                                                                                                            
    SP5:                          -     -     -                                                                                                                     

    ExUns: 15
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for IMPDH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IMPDH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTACTCTG
    IMPDH2 Expression
    About this image


    IMPDH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Gonad
             Spermatid Seminiferous Tubules
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Testis (Reproductive System)
             Spermatid Seminiferous Tubules
    IMPDH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IMPDH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654400

    UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268
    Tissue specificity: IMP type I is the main species in normal leukocytes and type II predominates over type I in
    the tumor

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IMPDH2 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Impdh21 , 5 inosine 5'-phosphate dehydrogenase 21, 5 90.08(n)1
    98.83(a)1
      9 (59.50 cM)5
    239181  NM_011830.31  NP_035960.21 
     1085605345 
    chicken
    (Gallus gallus)
    Aves IMPDH21 IMP (inosine 5'-monophosphate) dehydrogenase 2 80.35(n)
    94.94(a)
      416058  NM_001030601.1  NP_001025772.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Inosine-5'-monophosphate dehydrogenase
    88(a)
    many ↔ many
    2(187890460-187925010)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC042315.12   -- 77.22(n)    BC042315.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.26362 Danio rerio mRNA similar to IMP (inosine monophosphate) more 78.83(n)    BC046905.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T22D1.36
    Protein T22D1.3, isoform a
    53(a)
    many ↔ many
    IV(6913538-6917116) WBGene00020682
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IMD2(YHR216W)4 Inosine monophosphate dehydrogenase, catalyzes the more   --   8(554396-555967) 856626  NP_012088.1 
    soybean
    (Glycine max)
    eudicotyledons Gma.8982 Glycine max mRNA for inosine monophosphate dehydrogenase 72.5(n)    AJ010201.1 
    rice
    (Oryza sativa)
    Liliopsida Os.47382 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.57(n)    AK065289.1 


    ENSEMBL Gene Tree for IMPDH2 (if available)
    TreeFam Gene Tree for IMPDH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IMPDH2 gene
    IMPDH12  GMPR22  GMPR2  
    3 SIMAP similar genes for IMPDH2 using alignment to 6 protein entries:     IMDH2_HUMAN (see all proteins):
    DKFZp781N0678    IMPDH1    GMPR2

    Find genes that share paralogs with IMPDH2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    IMDH2_HUMAN, P12268: Genetic variants in the IMPDH2 gene may account for the large inter-individual variability in enzyme
    activity, immunosuppressive efficacy and side effects in transplant recipients receiving mycophenolic acid


    Selected SNPs for IMPDH2 (see all 232)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs726249151,2
    C,F--48995864(-) CCTGGC/TCTTCT 1 -- int11Minor allele frequency- T:0.00--576
    rs726249131,2
    C--48996073(-) ATTACG/ACAGGA 2 /T syn12Minor allele frequency- A:0.00NA 5056
    rs1903470331,2
    C--48996145(+) TTGGCC/TTGGGC 2 Q syn10--------
    rs115575461,2
    C,F--48996157(-) GTGGTC/GACTGC 2 V syn12Minor allele frequency- G:0.00NA EU 5781
    rs726249121,2
    C--48996235(-) GAAGGA/GTGTGT 1 -- int11Minor allele frequency- G:0.00--576
    rs1816731031,2
    C--48996415(+) CACCTA/GTGTAG 1 -- int10--------
    rs117060521,2
    C,F,H--48996419(+) TGTGTA/GGCAGC 1 -- int123Minor allele frequency- G:0.08NS EA NA EU 4262
    rs1490472261,2
    C,F--48996435(+) AAAACC/TACTAC 2 V syn12Minor allele frequency- T:0.00NA EU 5873
    rs115575441,2
    C--48996528(-) GATGCC/TAAGAA 2 A syn12Minor allele frequency- T:0.00NA 4
    rs1858526341,2
    C--48996545(+) GGCTAA/GTGGGT 2 L syn10--------

    HapMap Linkage Disequilibrium report for IMPDH2 (49061758 - 49066875 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IMPDH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876764CNV Loss21882294

    Human Gene Mutation Database (HGMD): IMPDH2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IMPDH2
    DNA2.0 Custom Variant and Variant Library Synthesis for IMPDH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 146691    OMIM disorders: --


    Find genes that share disorders with IMPDH2           About GenesLikeMe

    3 Novoseek inferred disease relationships for IMPDH2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 8.66 7 20233875 (1), 19108589 (1), 18976158 (1), 19583440 (1)
    leukemia 0 1 11370715 (1)
    tumors 0 6 18976158 (1), 19597826 (1)

    Genetic Association Database (GAD): IMPDH2
    Human Genome Epidemiology (HuGE) Navigator: IMPDH2 (13 documents)

    Export disorders for IMPDH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IMPDH2 gene, integrated from 10 sources (see all 132):
    (articles sorted by number of sources associating them with IMPDH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity. (PubMed id 17496727)1, 2, 4, 7, 9 Wang J....Burckart G.J. (Pharmacogenet. Genomics 2007)
    2. Two distinct cDNAs for human IMP dehydrogenase. (PubMed id 1969416)1, 2, 3 Natsumeda Y.... Suzuki K. (J. Biol. Chem. 1990)
    3. An exploratory study on pharmacogenetics of inosine-monophosphate dehydrogenase II in peripheral mononuclear cells from liver-transplant recipients. (PubMed id 15621150)1, 7, 9 Vannozzi F....Del Tacca M. (Transplant. Proc. 2004)
    4. Interpopulation variation frequency of human inosine 5'-monophosphate dehydrogenase type II (IMPDH2) genetic polymorphisms. (PubMed id 18976158)1, 4, 9 Mohamed M.F....Langaee T.Y. (Genet. Test. 2008)
    5. Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals. (PubMed id 20045992)1, 4, 9 Kudo M....Hiratsuka M. (Drug Metab. Pharmacokinet. 2009)
    6. Chromosomal localization and structure of the human type II IMP dehydrogenase gene. (PubMed id 8098009)1, 2, 9 Glesne D.A.... Huberman E. (Genomics 1993)
    7. An inosine 5'-monophosphate dehydrogenase 2 single-nucleotide polymorphism impairs the effect of mycophenolic acid. (PubMed id 19770842)1, 4, 9 Winnicki W....Sengoelge G. (Pharmacogenomics J. 2010)
    8. Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design. (PubMed id 10097070)1, 2, 9 Colby T.D....Goldstein B.M. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    9. Assignment1 of inosine '-monophosphate dehydrogenase type 2 (IMPDH2) to human chromosome band 3p21.2 by in situ hybridization. (PubMed id 9858805)1, 3, 9 Kost-Alimova M.V....Zelenin A.V. (Cytogenet. Cell Genet. 1998)
    10. Characterization of the human inosine-5'-monophosphate dehydrogenase type II gene. (PubMed id 7896827)1, 2, 9 Zimmermann A.G.... Mitchell B.S. (J. Biol. Chem. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3615 HGNC: 6053 AceView: IMPDH2 Ensembl:ENSG00000178035 euGenes: HUgn3615
    ECgene: IMPDH2 Kegg: 3615 H-InvDB: IMPDH2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IMPDH2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IMPDH2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IMPDH2 gene:
    Search GeneIP for patents involving IMPDH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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