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Aliases for IMPDH2 Gene

Aliases for IMPDH2 Gene

  • Inosine Monophosphate Dehydrogenase 2 2 3 5
  • IMP (Inosine 5-Monophosphate) Dehydrogenase 2 2 3
  • EC 1.1.1.205 4 58
  • IMPDH-II 3 4
  • IMPDH 2 3 4
  • IMPD 2 3 4
  • IMPD2 3 4
  • IMP (Inosine Monophosphate) Dehydrogenase 2 3
  • Inosine Monophosphate Dehydrogenase Type II 3
  • Inosine-5-Monophosphate Dehydrogenase 2 3
  • Inosine 5 Phosphate Dehydrogenase 2 3
  • IMP Dehydrogenase 2 4
  • IMP Oxireductase 2 3

External Ids for IMPDH2 Gene

Previous GeneCards Identifiers for IMPDH2 Gene

  • GC03U990046
  • GC03M048208
  • GC03M048916
  • GC03M049020
  • GC03M049036
  • GC03M049061
  • GC03M049071
  • GC03M049080
  • GC03M049085
  • GC03M049090
  • GC03M049096
  • GC03M049102

Summaries for IMPDH2 Gene

Entrez Gene Summary for IMPDH2 Gene

  • This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

GeneCards Summary for IMPDH2 Gene

IMPDH2 (Inosine Monophosphate Dehydrogenase 2) is a Protein Coding gene. Diseases associated with IMPDH2 include Bartter Syndrome, Type 3 and Retinitis Pigmentosa. Among its related pathways are Metabolism and Irinotecan Pathway. GO annotations related to this gene include RNA binding and oxidoreductase activity. An important paralog of this gene is IMPDH1.

UniProtKB/Swiss-Prot for IMPDH2 Gene

  • Catalyzes the conversion of inosine 5-phosphate (IMP) to xanthosine 5-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Tocris Summary for IMPDH2 Gene

Gene Wiki entry for IMPDH2 Gene

Additional gene information for IMPDH2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMPDH2 Gene

Genomics for IMPDH2 Gene

Regulatory Elements for IMPDH2 Gene

Enhancers for IMPDH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H049338 1.9 FANTOM5 ENCODE dbSUPER 20.7 -316.3 -316349 14 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 AMT QRICH1 ATRIP ENSG00000235236 WDR6 RBM6 BSN-AS1 DALRD3 RBM5 IP6K2
GH03H049686 1.3 ENCODE dbSUPER 12.2 -658.6 -658647 4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 AMT RBM6 QRICH1 CDHR4 AMIGO3 GMPPB IMPDH2 USP19 PHF5EP IP6K1
GH03H049005 1.4 ENCODE dbSUPER 10.7 +22.3 22323 3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 WDR6 ATRIP QRICH1 USP19 CCDC36 ENSG00000225399 PRKAR2A IMPDH2 ENSG00000235236 ARIH2
GH03H049443 1.4 Ensembl ENCODE dbSUPER 10.3 -415.5 -415534 3 HDGF TBL1XR1 ARNT BATF THRB GTF3C2 ZNF207 FOS ATF7 ETV6 AMT QRICH1 IP6K2 USP19 TMEM115 QARS ATRIP SEMA3F-AS1 RHOA-IT1 WDR6
GH03H049217 1.3 Ensembl ENCODE 10.3 -189.0 -188981 2 FOXA2 MLX ZNF133 ARID4B DMAP1 GTF3C2 SLC30A9 ATF7 FOS SP5 WDR6 AMT QARS QRICH1 CCDC71 RBM5 ZNF589 RBM6 USP19 NME6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IMPDH2 on UCSC Golden Path with GeneCards custom track

Promoters for IMPDH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152180 401 601 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 FOS

Genomic Location for IMPDH2 Gene

Chromosome:
3
Start:
49,024,325 bp from pter
End:
49,029,701 bp from pter
Size:
5,377 bases
Orientation:
Minus strand

Genomic View for IMPDH2 Gene

Genes around IMPDH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IMPDH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IMPDH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMPDH2 Gene

Proteins for IMPDH2 Gene

  • Protein details for IMPDH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12268-IMDH2_HUMAN
    Recommended name:
    Inosine-5-monophosphate dehydrogenase 2
    Protein Accession:
    P12268
    Secondary Accessions:
    • Q6LEF3

    Protein attributes for IMPDH2 Gene

    Size:
    514 amino acids
    Molecular mass:
    55805 Da
    Cofactor:
    Name=K(+); Xref=ChEBI:CHEBI:29103;
    Quaternary structure:
    • Homotetramer.
    Miscellaneous:
    • Because IMPDH activity is tightly linked with cell proliferation, it has been recognized as a target for cancer and viral chemotherapy and as a target for immunosuppressive drugs. The activities of the antitumor drug tiazofurin, the antiviral drug ribavirin, and the immunosuppressive drugs mizoribine and mycophenolic acid (MPA) are attributed to the inhibition of IMPDH. In addition, bacterial and parasitic IMPDHs differ significantly from mammalian enzymes, which makes it a suitable target for anti-infective drugs.

    Three dimensional structures from OCA and Proteopedia for IMPDH2 Gene

neXtProt entry for IMPDH2 Gene

Selected DME Specific Peptides for IMPDH2 Gene

P12268:
  • YRGMGSL
  • NDFLILPG
  • GGIGFIHHNCTPEFQANEVRKVKK
  • GMGSGSICITQE
  • EDDKYRLDLL
  • KKGKLPIV
  • KFVPYLIAGIQH
  • VMMGSLLA
  • DGLTAQQLF
  • MMYSGELKFEKRT
  • VAQGVSG
  • LGASTVMMGS
  • VIADGGIQNVGH
  • KITLKTPL
  • QHSCQDIG
  • IARTDLKK
  • EAPGEYFFSDG
  • GIPITDTG
  • AQAKNLIDAGVD
  • EQGFITDPVVLSP
  • SKKGKLP
  • VSSPMDTVTE
  • GLTYNDF
  • RYFSEADK

Post-translational modifications for IMPDH2 Gene

  • The N-terminus is blocked.
  • Ubiquitination at posLast=134134, isoforms=195, isoforms=208, posLast=293293, posLast=311311, isoforms=349, posLast=450450, isoforms=455, isoforms=474, and isoforms=489
  • Modification sites at PhosphoSitePlus

Other Protein References for IMPDH2 Gene

Antibody Products

  • R&D Systems Antibodies for IMPDH2 (IMP Dehydrogenase 2/IMPDH2)
  • Abcam antibodies for IMPDH2

Domains & Families for IMPDH2 Gene

Gene Families for IMPDH2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P12268

UniProtKB/Swiss-Prot:

IMDH2_HUMAN :
  • Belongs to the IMPDH/GMPR family.
Family:
  • Belongs to the IMPDH/GMPR family.
genes like me logo Genes that share domains with IMPDH2: view

Function for IMPDH2 Gene

Molecular function for IMPDH2 Gene

GENATLAS Biochemistry:
inosine 5-monophosphate dehydrogenase,type II,paralog to IMPDH1
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=9.3 uM for Inosine 5-phosphate {ECO:0000269 PubMed:7763314, ECO:0000269 PubMed:7903306}; KM=32 uM for NAD(+) {ECO:0000269 PubMed:7763314, ECO:0000269 PubMed:7903306};
UniProtKB/Swiss-Prot CatalyticActivity:
Inosine 5-phosphate + NAD(+) + H(2)O = xanthosine 5-phosphate + NADH.
UniProtKB/Swiss-Prot EnzymeRegulation:
Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. Subject to product inhibition by XMP and NADH. Also inhibited by ADP.
UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of inosine 5-phosphate (IMP) to xanthosine 5-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
UniProtKB/Swiss-Prot Induction:
Selectively up-regulated in neoplastic and replicating cells.

Enzyme Numbers (IUBMB) for IMPDH2 Gene

Phenotypes From GWAS Catalog for IMPDH2 Gene

Gene Ontology (GO) - Molecular Function for IMPDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IDA 14766016
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0003824 catalytic activity IEA --
GO:0003938 IMP dehydrogenase activity EXP,IBA --
genes like me logo Genes that share ontologies with IMPDH2: view
genes like me logo Genes that share phenotypes with IMPDH2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IMPDH2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IMPDH2 Gene

Localization for IMPDH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IMPDH2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IMPDH2 gene
Compartment Confidence
extracellular 5
peroxisome 5
nucleus 5
cytosol 5
mitochondrion 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Rods & Rings (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IMPDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA,IDA 14766016
GO:0005737 cytoplasm IEA,IDA 14766016
GO:0005778 peroxisomal membrane IDA 21525035
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with IMPDH2: view

Pathways & Interactions for IMPDH2 Gene

genes like me logo Genes that share pathways with IMPDH2: view

UniProtKB/Swiss-Prot P12268-IMDH2_HUMAN

  • Pathway: Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.

Gene Ontology (GO) - Biological Process for IMPDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006164 purine nucleotide biosynthetic process IEA --
GO:0006177 GMP biosynthetic process IEA --
GO:0006183 GTP biosynthetic process IBA --
GO:0009168 purine ribonucleoside monophosphate biosynthetic process TAS --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with IMPDH2: view

No data available for SIGNOR curated interactions for IMPDH2 Gene

Drugs & Compounds for IMPDH2 Gene

(18) Drugs for IMPDH2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mycophenolate mofetil Approved, Investigational Pharma inhibitor, Target IMPDH inhibitor 972
Mycophenolic acid Approved Pharma inhibitor, Target 972
Ribavirin Approved Pharma inhibitor, Target 1011
Mercaptopurine Approved Pharma Target, inhibitor 0
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0

(8) Additional Compounds for IMPDH2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
6-Thioinosine-5'-monophosphate
6-Thioxanthine 5'-monophosphate
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Xanthylic acid
  • (9-D-ribosylxanthine)-5'-phosphate
  • 5'-Xanthonylate monophosphate
  • Xanthosine 5'-phosphate
  • Xanthosine-5'-P
  • Xanthosine-5'-phosphate
523-98-8

(4) ApexBio Compounds for IMPDH2 Gene

Compound Action Cas Number
Ammonium Glycyrrhizinate 1407-03-0
Mizoribine 50924-49-7
Mycophenolate Mofetil IMPDH inhibitor 128794-94-5
Mycophenolic acid 24280-93-1
genes like me logo Genes that share compounds with IMPDH2: view

Drug Products

Transcripts for IMPDH2 Gene

Unigene Clusters for IMPDH2 Gene

IMP (inosine 5-monophosphate) dehydrogenase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IMPDH2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IMPDH2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
SP1: - -
SP2: - -
SP3: -
SP4:
SP5: - - -
SP6: - -
SP7:
SP8:
SP9: - - - -
SP10:

ExUns: 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for IMPDH2 Gene

GeneLoc Exon Structure for
IMPDH2
ECgene alternative splicing isoforms for
IMPDH2

Expression for IMPDH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IMPDH2 Gene

Protein differential expression in normal tissues from HIPED for IMPDH2 Gene

This gene is overexpressed in Breast (11.5), Lymph node (7.2), and Fetal ovary (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IMPDH2 Gene



Protein tissue co-expression partners for IMPDH2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IMPDH2 Gene:

IMPDH2

SOURCE GeneReport for Unigene cluster for IMPDH2 Gene:

Hs.654400

mRNA Expression by UniProt/SwissProt for IMPDH2 Gene:

P12268-IMDH2_HUMAN
Tissue specificity: IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.

Evidence on tissue expression from TISSUES for IMPDH2 Gene

  • Blood(4.7)
  • Intestine(4.7)
  • Nervous system(4.7)
  • Liver(4.5)
  • Lung(4.5)
  • Eye(4.4)
  • Skin(4.3)
  • Spleen(4.3)
  • Kidney(3.3)
  • Muscle(2.4)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with IMPDH2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IMPDH2 Gene

Orthologs for IMPDH2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IMPDH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IMPDH2 33 34
  • 99.94 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 97 (a)
ManyToMany
-- 34
  • 75 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 96 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia IMPDH2 33 34
  • 92.15 (n)
cow
(Bos Taurus)
Mammalia IMPDH2 33 34
  • 91.31 (n)
mouse
(Mus musculus)
Mammalia Impdh2 34 33
  • 90.08 (n)
ManyToMany
Impdh2-ps 16
rat
(Rattus norvegicus)
Mammalia Impdh2 33
  • 89.49 (n)
chicken
(Gallus gallus)
Aves IMPDH2 33
  • 80.35 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 88 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia impdh2 33
  • 78.6 (n)
zebrafish
(Danio rerio)
Actinopterygii impdh2 33 34
  • 76.98 (n)
Dr.2636 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13891 33
fruit fly
(Drosophila melanogaster)
Insecta ras 35
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea T22D1.3 34
  • 53 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IMD3 34 36
  • 61 (a)
ManyToMany
IMD4 34
  • 61 (a)
ManyToMany
IMD2 34
  • 60 (a)
ManyToMany
IMD1 34
  • 55 (a)
ManyToMany
soybean
(Glycine max)
eudicotyledons Gma.898 33
barley
(Hordeum vulgare)
Liliopsida Hv.10632 33
rice
(Oryza sativa)
Liliopsida Os.4738 33
wheat
(Triticum aestivum)
Liliopsida Ta.3649 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8181 34
  • 57 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4205 33
Species where no ortholog for IMPDH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for IMPDH2 Gene

ENSEMBL:
Gene Tree for IMPDH2 (if available)
TreeFam:
Gene Tree for IMPDH2 (if available)

Paralogs for IMPDH2 Gene

Paralogs for IMPDH2 Gene

(3) SIMAP similar genes for IMPDH2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IMPDH2: view

Variants for IMPDH2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IMPDH2 Gene

IMDH2_HUMAN-P12268
Genetic variants in the IMPDH2 gene may account for the large inter-individual variability in enzyme activity, immunosuppressive efficacy and side effects in transplant recipients receiving mycophenolic acid.

Sequence variations from dbSNP and Humsavar for IMPDH2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs121434586 other 49,026,719(-) ACTTG(C/T)TCGCC reference, missense
rs1000245176 -- 49,027,122(+) CCCAA(G/T)TAGCT intron-variant
rs1002423663 -- 49,026,858(+) AGCTC(A/T)TCATC reference, missense
rs1002729214 -- 49,028,476(+) ATGGG(A/G)GAGGA reference, synonymous-codon
rs1002784462 -- 49,024,589(+) GAAGG(A/G)CAGAG intron-variant

Variation tolerance for IMPDH2 Gene

Residual Variation Intolerance Score: 8.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IMPDH2 Gene

Human Gene Mutation Database (HGMD)
IMPDH2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IMPDH2

No data available for Structural Variations from Database of Genomic Variants (DGV) for IMPDH2 Gene

Disorders for IMPDH2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IMPDH2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
bartter syndrome, type 3
  • bartter disease type 3
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IMPDH2

Genetic Association Database (GAD)
IMPDH2
Human Genome Epidemiology (HuGE) Navigator
IMPDH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IMPDH2
genes like me logo Genes that share disorders with IMPDH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IMPDH2 Gene

Publications for IMPDH2 Gene

  1. A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity. (PMID: 17496727) Wang J … Burckart GJ (Pharmacogenetics and genomics 2007) 3 4 22 25 45 60
  2. An inosine 5'-monophosphate dehydrogenase 2 single-nucleotide polymorphism impairs the effect of mycophenolic acid. (PMID: 19770842) Winnicki W … Sengoelge G (The pharmacogenomics journal 2010) 3 22 45 60
  3. Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals. (PMID: 20045992) Kudo M … Hiratsuka M (Drug metabolism and pharmacokinetics 2009) 3 22 45 60
  4. Interpopulation variation frequency of human inosine 5'-monophosphate dehydrogenase type II (IMPDH2) genetic polymorphisms. (PMID: 18976158) Mohamed MF … Langaee TY (Genetic testing 2008) 3 22 45 60
  5. An exploratory study on pharmacogenetics of inosine-monophosphate dehydrogenase II in peripheral mononuclear cells from liver-transplant recipients. (PMID: 15621150) Vannozzi F … Del Tacca M (Transplantation proceedings 2004) 3 22 25 60

Products for IMPDH2 Gene

Sources for IMPDH2 Gene

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