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Aliases for IMPDH2 Gene

Aliases for IMPDH2 Gene

  • IMP (Inosine 5'-Monophosphate) Dehydrogenase 2 2
  • IMP (Inosine 5-Monophosphate) Dehydrogenase 2 2 3 5
  • EC 1.1.1.205 4 63
  • IMPDH-II 3 4
  • IMPDH 2 3 4
  • IMPD 2 3 4
  • IMPD2 3 4
  • IMP (Inosine Monophosphate) Dehydrogenase 2 3
  • Inosine Monophosphate Dehydrogenase Type II 3
  • Inosine 5 Phosphate Dehydrogenase 2 3
  • IMP Dehydrogenase 2 4
  • IMP Oxireductase 2 3

External Ids for IMPDH2 Gene

Previous GeneCards Identifiers for IMPDH2 Gene

  • GC03U990046
  • GC03M048208
  • GC03M048916
  • GC03M049020
  • GC03M049036
  • GC03M049061
  • GC03M049071
  • GC03M049080

Summaries for IMPDH2 Gene

Entrez Gene Summary for IMPDH2 Gene

  • This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

GeneCards Summary for IMPDH2 Gene

IMPDH2 (IMP (Inosine 5'-Monophosphate) Dehydrogenase 2) is a Protein Coding gene. Diseases associated with IMPDH2 include Retinitis Pigmentosa. Among its related pathways are Purine metabolism and purine nucleotides de novo biosynthesis. GO annotations related to this gene include RNA binding and oxidoreductase activity. An important paralog of this gene is GMPR2.

UniProtKB/Swiss-Prot for IMPDH2 Gene

  • Catalyzes the conversion of inosine 5-phosphate (IMP) to xanthosine 5-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Tocris Summary for IMPDH2 Gene

Gene Wiki entry for IMPDH2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMPDH2 Gene

Genomics for IMPDH2 Gene

Regulatory Elements for IMPDH2 Gene

Enhancers for IMPDH2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IMPDH2 on UCSC Golden Path with GeneCards custom track

Promoters for IMPDH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IMPDH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IMPDH2 Gene

Chromosome:
3
Start:
49,024,325 bp from pter
End:
49,029,701 bp from pter
Size:
5,377 bases
Orientation:
Minus strand

Genomic View for IMPDH2 Gene

Genes around IMPDH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IMPDH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IMPDH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMPDH2 Gene

Proteins for IMPDH2 Gene

  • Protein details for IMPDH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12268-IMDH2_HUMAN
    Recommended name:
    Inosine-5-monophosphate dehydrogenase 2
    Protein Accession:
    P12268
    Secondary Accessions:
    • Q6LEF3

    Protein attributes for IMPDH2 Gene

    Size:
    514 amino acids
    Molecular mass:
    55805 Da
    Cofactor:
    Name=K(+); Xref=ChEBI:CHEBI:29103;
    Quaternary structure:
    • Homotetramer.
    Miscellaneous:
    • Because IMPDH activity is tightly linked with cell proliferation, it has been recognized as a target for cancer and viral chemotherapy and as a target for immunosuppressive drugs. The activities of the antitumor drug tiazofurin, the antiviral drug ribavirin, and the immunosuppressive drugs mizoribine and mycophenolic acid (MPA) are attributed to the inhibition of IMPDH. In addition, bacterial and parasitic IMPDHs differ significantly from mammalian enzymes, which makes it a suitable target for anti-infective drugs.

    Three dimensional structures from OCA and Proteopedia for IMPDH2 Gene

neXtProt entry for IMPDH2 Gene

Proteomics data for IMPDH2 Gene at MOPED

Post-translational modifications for IMPDH2 Gene

  • The N-terminus is blocked.
  • Ubiquitination at Lys 134, Lys 195, Lys 208, Lys 293, Lys 311, Lys 349, Lys 450, Lys 455, Lys 474, and Lys 489
  • Modification sites at PhosphoSitePlus

Other Protein References for IMPDH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IMPDH2 (IMP Dehydrogenase 2/IMPDH2)

Domains & Families for IMPDH2 Gene

Graphical View of Domain Structure for InterPro Entry

P12268

UniProtKB/Swiss-Prot:

IMDH2_HUMAN :
  • Contains 2 CBS domains.
  • Belongs to the IMPDH/GMPR family.
Domain:
  • Contains 2 CBS domains.
Family:
  • Belongs to the IMPDH/GMPR family.
genes like me logo Genes that share domains with IMPDH2: view

No data available for Gene Families for IMPDH2 Gene

Function for IMPDH2 Gene

Molecular function for IMPDH2 Gene

GENATLAS Biochemistry:
inosine 5-monophosphate dehydrogenase,type II,paralog to IMPDH1
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=9.3 uM for Inosine 5-phosphate {ECO:0000269 PubMed:7763314, ECO:0000269 PubMed:7903306}; KM=32 uM for NAD(+) {ECO:0000269 PubMed:7763314, ECO:0000269 PubMed:7903306};
UniProtKB/Swiss-Prot CatalyticActivity:
Inosine 5-phosphate + NAD(+) + H(2)O = xanthosine 5-phosphate + NADH.
UniProtKB/Swiss-Prot EnzymeRegulation:
Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. Subject to product inhibition by XMP and NADH. Also inhibited by ADP.
UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of inosine 5-phosphate (IMP) to xanthosine 5-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
UniProtKB/Swiss-Prot Induction:
Selectively up-regulated in neoplastic and replicating cells.

Enzyme Numbers (IUBMB) for IMPDH2 Gene

Gene Ontology (GO) - Molecular Function for IMPDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IDA 14766016
GO:0003824 catalytic activity IEA --
GO:0003938 IMP dehydrogenase activity EXP,IEA 7763314
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with IMPDH2: view
genes like me logo Genes that share phenotypes with IMPDH2: view

Animal Models for IMPDH2 Gene

MGI Knock Outs for IMPDH2:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IMPDH2 Gene

Localization for IMPDH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IMPDH2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IMPDH2 Gene COMPARTMENTS Subcellular localization image for IMPDH2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
peroxisome 5
mitochondrion 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for IMPDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 14766016
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with IMPDH2: view

Pathways & Interactions for IMPDH2 Gene

genes like me logo Genes that share pathways with IMPDH2: view

UniProtKB/Swiss-Prot P12268-IMDH2_HUMAN

  • Pathway: Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.

Gene Ontology (GO) - Biological Process for IMPDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009168 purine ribonucleoside monophosphate biosynthetic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046651 lymphocyte proliferation IEA --
GO:0051289 protein homotetramerization IEA --
GO:0055086 nucleobase-containing small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with IMPDH2: view

No data available for SIGNOR curated interactions for IMPDH2 Gene

Drugs & Compounds for IMPDH2 Gene

(18) Drugs for IMPDH2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mycophenolic acid Approved Pharma inhibitor, Target 906
Mycophenolate mofetil Approved, Investigational Pharma inhibitor, Target IMPDH inhibitor 906
Mercaptopurine Approved Pharma Target, Inhibitor 0
Cyclosporine Approved, Investigational Pharma Immunosuppressant drug 0
Ribavirin Approved Pharma inhibitor 962

(9) Additional Compounds for IMPDH2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
6-Thioinosine-5'-monophosphate
6-Thioxanthine 5'-monophosphate
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Xanthylic acid
  • (9-D-ribosylxanthine)-5'-phosphate
  • 5'-Xanthonylate monophosphate
  • Xanthosine 5'-phosphate
  • Xanthosine-5'-P
  • Xanthosine-5'-phosphate
523-98-8

(3) ApexBio Compounds for IMPDH2 Gene

Compound Action Cas Number
Ammonium Glycyrrhizinate 1407-03-0
Mizoribine 50924-49-7
Mycophenolic acid 24280-93-1
genes like me logo Genes that share compounds with IMPDH2: view

Transcripts for IMPDH2 Gene

Unigene Clusters for IMPDH2 Gene

IMP (inosine 5-monophosphate) dehydrogenase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IMPDH2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
SP1: - -
SP2: - -
SP3: -
SP4:
SP5: - - -
SP6: - -
SP7:
SP8:
SP9: - - - -
SP10:

ExUns: 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for IMPDH2 Gene

GeneLoc Exon Structure for
IMPDH2
ECgene alternative splicing isoforms for
IMPDH2

Expression for IMPDH2 Gene

mRNA expression in normal human tissues for IMPDH2 Gene

Protein differential expression in normal tissues from HIPED for IMPDH2 Gene

This gene is overexpressed in Breast (11.5), Lymph node (7.2), and Fetal ovary (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IMPDH2 Gene



SOURCE GeneReport for Unigene cluster for IMPDH2 Gene Hs.654400

mRNA Expression by UniProt/SwissProt for IMPDH2 Gene

P12268-IMDH2_HUMAN
Tissue specificity: IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
genes like me logo Genes that share expression patterns with IMPDH2: view

Protein tissue co-expression partners for IMPDH2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for IMPDH2 Gene

Orthologs for IMPDH2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IMPDH2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IMPDH2 35
  • 91.31 (n)
  • 98.05 (a)
IMPDH2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IMPDH2 35
  • 92.15 (n)
  • 99.42 (a)
IMPDH2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Impdh2 35
  • 90.08 (n)
  • 98.83 (a)
Impdh2 16
Impdh2 36
  • 99 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia IMPDH2 35
  • 99.94 (n)
  • 100 (a)
IMPDH2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Impdh2 35
  • 89.49 (n)
  • 98.44 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
ManyToMany
-- 36
  • 97 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 96 (a)
ManyToMany
chicken
(Gallus gallus)
Aves IMPDH2 35
  • 80.35 (n)
  • 94.94 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia impdh2 35
  • 78.6 (n)
  • 93.19 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.2636 35
impdh2 35
  • 76.98 (n)
  • 91.25 (a)
impdh2 36
  • 91 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13891 35
fruit fly
(Drosophila melanogaster)
Insecta ras 37
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea T22D1.3 36
  • 53 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IMD1 36
  • 55 (a)
ManyToMany
IMD2 36
  • 60 (a)
ManyToMany
IMD3 36
  • 61 (a)
ManyToMany
IMD4 36
  • 61 (a)
ManyToMany
IMD2 38
soybean
(Glycine max)
eudicotyledons Gma.898 35
barley
(Hordeum vulgare)
Liliopsida Hv.10632 35
rice
(Oryza sativa)
Liliopsida Os.4738 35
wheat
(Triticum aestivum)
Liliopsida Ta.3649 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4205 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8181 36
  • 57 (a)
OneToMany
Species with no ortholog for IMPDH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for IMPDH2 Gene

ENSEMBL:
Gene Tree for IMPDH2 (if available)
TreeFam:
Gene Tree for IMPDH2 (if available)

Paralogs for IMPDH2 Gene

Paralogs for IMPDH2 Gene

(3) SIMAP similar genes for IMPDH2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IMPDH2: view

Variants for IMPDH2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IMPDH2 Gene

IMDH2_HUMAN-P12268
Genetic variants in the IMPDH2 gene may account for the large inter-individual variability in enzyme activity, immunosuppressive efficacy and side effects in transplant recipients receiving mycophenolic acid.

Sequence variations from dbSNP and Humsavar for IMPDH2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs121434586 - 49,026,719(-) ACTTG(C/T)TCGCC reference, missense
rs1049818 -- 49,024,386(-) CTTTT(C/T)TGAAA reference, synonymous-codon
rs1134122 -- 49,024,299(+) CCCAC(A/C)TGTCT downstream-variant-500B
rs11557540 -- 49,024,938(+) TCTCG(A/C/G/T)TGCCA reference, missense
rs11557541 -- 49,028,302(-) GGCTT(C/T)ATCCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IMPDH2 Gene

Variant ID Type Subtype PubMed ID
nsv876764 CNV Loss 21882294

Variation tolerance for IMPDH2 Gene

Residual Variation Intolerance Score: 8.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IMPDH2 Gene

Human Gene Mutation Database (HGMD)
IMPDH2

Disorders for IMPDH2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IMPDH2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IMPDH2

Genetic Association Database (GAD)
IMPDH2
Human Genome Epidemiology (HuGE) Navigator
IMPDH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IMPDH2
genes like me logo Genes that share disorders with IMPDH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IMPDH2 Gene

Publications for IMPDH2 Gene

  1. A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity. (PMID: 17496727) Wang J. … Burckart G.J. (Pharmacogenet. Genomics 2007) 3 4 23 25 26 48 67
  2. An exploratory study on pharmacogenetics of inosine-monophosphate dehydrogenase II in peripheral mononuclear cells from liver-transplant recipients. (PMID: 15621150) Vannozzi F. … Del Tacca M. (Transplant. Proc. 2004) 3 23 25 26
  3. Ex vivo selection and expansion of cells based on expression of a mutated inosine monophosphate dehydrogenase 2 after HIV vector transduction: effects on lymphocytes, monocytes, and CD34+ stem cells. (PMID: 16647299) Yam P. … Yee J.K. (Mol. Ther. 2006) 23 25 26
  4. Sensitization of human erythroleukemia K562 cells resistant to methotrexate by inhibiting IMPDH. (PMID: 15614187) PeA+uelas S. … Ciudad C.J. (Med. Sci. Monit. 2005) 23 25 26
  5. Assignment1 of inosine '-monophosphate dehydrogenase type 2 (IMPDH2) to human chromosome band 3p21.2 by in situ hybridization. (PMID: 9858805) Kost-Alimova M.V. … Zelenin A.V. (Cytogenet. Cell Genet. 1998) 2 3 23

Products for IMPDH2 Gene

Sources for IMPDH2 Gene

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