Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IMPDH2 Gene

Aliases for IMPDH2 Gene

  • IMP (Inosine 5'-Monophosphate) Dehydrogenase 2 2
  • IMPD2 3 4 6
  • IMP (Inosine 5-Monophosphate) Dehydrogenase 2 2 3
  • EC 1.1.1.205 4 63
  • IMPDH-II 3 4
  • IMPDH 2 3 4
  • IMPD 2 3 4
  • IMP (Inosine Monophosphate) Dehydrogenase 2 3
  • Inosine Monophosphate Dehydrogenase Type II 3
  • Inosine-5-Monophosphate Dehydrogenase 2 3
  • Inosine 5 Phosphate Dehydrogenase 2 3
  • IMP Dehydrogenase 2 4
  • IMP Oxireductase 2 3

External Ids for IMPDH2 Gene

Previous GeneCards Identifiers for IMPDH2 Gene

  • GC03U990046
  • GC03M048208
  • GC03M048916
  • GC03M049020
  • GC03M049036
  • GC03M049061

Summaries for IMPDH2 Gene

Entrez Gene Summary for IMPDH2 Gene

  • This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

GeneCards Summary for IMPDH2 Gene

IMPDH2 (IMP (Inosine 5'-Monophosphate) Dehydrogenase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include RNA binding and adenyl nucleotide binding. An important paralog of this gene is GMPR.

UniProtKB/Swiss-Prot for IMPDH2 Gene

  • Catalyzes the conversion of inosine 5-phosphate (IMP) to xanthosine 5-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors

Gene Wiki entry for IMPDH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMPDH2 Gene

Genomics for IMPDH2 Gene

Regulatory Elements for IMPDH2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IMPDH2 Gene

Start:
49,024,325 bp from pter
End:
49,029,634 bp from pter
Size:
5,310 bases
Orientation:
Minus strand

Genomic View for IMPDH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IMPDH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMPDH2 Gene

Proteins for IMPDH2 Gene

  • Protein details for IMPDH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12268-IMDH2_HUMAN
    Recommended name:
    Inosine-5-monophosphate dehydrogenase 2
    Protein Accession:
    P12268
    Secondary Accessions:
    • Q6LEF3

    Protein attributes for IMPDH2 Gene

    Size:
    514 amino acids
    Molecular mass:
    55805 Da
    Cofactor:
    Name=K(+); Xref=ChEBI:CHEBI:29103;
    Quaternary structure:
    • Homotetramer.
    Miscellaneous:
    • Because IMPDH activity is tightly linked with cell proliferation, it has been recognized as a target for cancer and viral chemotherapy and as a target for immunosuppressive drugs. The activities of the antitumor drug tiazofurin, the antiviral drug ribavirin, and the immunosuppressive drugs mizoribine and mycophenolic acid (MPA) are attributed to the inhibition of IMPDH. In addition, bacterial and parasitic IMPDHs differ significantly from mammalian enzymes, which makes it a suitable target for anti-infective drugs

    Three dimensional structures from OCA and Proteopedia for IMPDH2 Gene

neXtProt entry for IMPDH2 Gene

Proteomics data for IMPDH2 Gene at MOPED

Post-translational modifications for IMPDH2 Gene

  • The N-terminus is blocked
  • Ubiquitination at Lys109, Lys124, Lys134, Lys195, Lys208, Lys293, Lys311, Lys349, Lys422, Lys450, Lys455, Lys474, and Lys489
  • Modification sites at PhosphoSitePlus

Other Protein References for IMPDH2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IMPDH2 (IMP Dehydrogenase 2/IMPDH2)

Domains for IMPDH2 Gene

Graphical View of Domain Structure for InterPro Entry

P12268

UniProtKB/Swiss-Prot:

IMDH2_HUMAN :
  • P12268
Domain:
  • Contains 2 CBS domains.
Family:
  • Belongs to the IMPDH/GMPR family.
genes like me logo Genes that share domains with IMPDH2: view

No data available for Gene Families for IMPDH2 Gene

Function for IMPDH2 Gene

Molecular function for IMPDH2 Gene

GENATLAS Biochemistry:
inosine 5-monophosphate dehydrogenase,type II,paralog to IMPDH1
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=9.3 uM for Inosine 5-phosphate {ECO:0000269 PubMed:7763314, ECO:0000269 PubMed:7903306}; KM=32 uM for NAD(+) {ECO:0000269 PubMed:7763314, ECO:0000269 PubMed:7903306};
UniProtKB/Swiss-Prot CatalyticActivity:
Inosine 5-phosphate + NAD(+) + H(2)O = xanthosine 5-phosphate + NADH.
UniProtKB/Swiss-Prot EnzymeRegulation:
Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. Subject to product inhibition by XMP and NADH. Also inhibited by ADP.
UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of inosine 5-phosphate (IMP) to xanthosine 5-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors
UniProtKB/Swiss-Prot Induction:
Selectively up-regulated in neoplastic and replicating cells

Enzyme Numbers (IUBMB) for IMPDH2 Gene

Gene Ontology (GO) - Molecular Function for IMPDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IDA 14766016
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0003824 catalytic activity --
GO:0003938 IMP dehydrogenase activity IEA --
genes like me logo Genes that share ontologies with IMPDH2: view
genes like me logo Genes that share phenotypes with IMPDH2: view

Animal Models for IMPDH2 Gene

MGI Knock Outs for IMPDH2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IMPDH2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for IMPDH2 Gene

Localization for IMPDH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IMPDH2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IMPDH2 Gene COMPARTMENTS Subcellular localization image for IMPDH2 gene
Compartment Confidence
nucleus 5
peroxisome 5
cytosol 4
mitochondrion 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for IMPDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14766016
GO:0005737 cytoplasm IDA 14766016
GO:0005778 peroxisomal membrane IDA 21525035
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with IMPDH2: view

Pathways for IMPDH2 Gene

genes like me logo Genes that share pathways with IMPDH2: view

UniProtKB/Swiss-Prot P12268-IMDH2_HUMAN

  • Pathway: Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.

Gene Ontology (GO) - Biological Process for IMPDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006051 N-acetylmannosamine metabolic process --
GO:0006144 purine nucleobase metabolic process TAS --
GO:0006164 purine nucleotide biosynthetic process --
GO:0006177 GMP biosynthetic process IEA --
GO:0009168 purine ribonucleoside monophosphate biosynthetic process TAS --
genes like me logo Genes that share ontologies with IMPDH2: view

Compounds for IMPDH2 Gene

(3) ApexBio Compounds for IMPDH2 Gene

Compound Action Cas Number
Ammonium Glycyrrhizinate [1407-03-0]
Mizoribine [50924-49-7]
Mycophenolic acid [24280-93-1]

(6) HMDB Compounds for IMPDH2 Gene

Compound Synonyms Cas Number PubMed IDs
Inosinic acid
  • 5'-IMP
131-99-7
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
Potassium
  • K+
7440-09-7
Water
  • Dihydrogen oxide
7732-18-5

(8) Drugbank Compounds for IMPDH2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
6-Chloropurine Riboside, 5'-Monophosphate
target
Inosinic Acid
131-99-7 target
Mycophenolate mofetil
  • MMF
128794-94-5 target inhibitor
Mycophenolic acid
24280-93-1 target inhibitor
NADH
  • beta-DPNH
606-68-8 target

(7) Novoseek inferred chemical compound relationships for IMPDH2 Gene

Compound -log(P) Hits PubMed IDs
inosine monophosphate 95.6 35
xanthosine-5-monophosphate 87.4 1
mycophenolic acid 84.8 11
purine 59.9 3
mycophenolate mofetil 57.1 4

(3) PharmGKB related drug/compound annotations for IMPDH2 Gene

Drug/compound Annotation
cyclosporine CA
mycophenolate mofetil CA
mycophenolic acid CA
genes like me logo Genes that share compounds with IMPDH2: view

Transcripts for IMPDH2 Gene

Unigene Clusters for IMPDH2 Gene

IMP (inosine 5-monophosphate) dehydrogenase 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IMPDH2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IMPDH2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
SP1: - -
SP2: - -
SP3: -
SP4:
SP5: - - -
SP6: - -
SP7:
SP8:
SP9: - - - -
SP10:

ExUns: 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for IMPDH2 Gene

GeneLoc Exon Structure for
IMPDH2
ECgene alternative splicing isoforms for
IMPDH2

Expression for IMPDH2 Gene

mRNA expression in normal human tissues for IMPDH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for IMPDH2 Gene

This gene is overexpressed in Breast (11.5), Lymph node (7.2), and Fetal ovary (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IMPDH2 Gene

SOURCE GeneReport for Unigene cluster for IMPDH2 Gene Hs.654400

mRNA Expression by UniProt/SwissProt for IMPDH2 Gene

P12268-IMDH2_HUMAN
Tissue specificity: IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor
genes like me logo Genes that share expressions with IMPDH2: view

Expression partners for IMPDH2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for IMPDH2 Gene

Orthologs for IMPDH2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IMPDH2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IMPDH2 35
  • 91.31 (n)
  • 98.05 (a)
IMPDH2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IMPDH2 35
  • 92.15 (n)
  • 99.42 (a)
IMPDH2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Impdh2 35
  • 90.08 (n)
  • 98.83 (a)
Impdh2 16
Impdh2 36
  • 99 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia IMPDH2 35
  • 99.94 (n)
  • 100 (a)
IMPDH2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Impdh2 35
  • 89.49 (n)
  • 98.44 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
ManyToMany
-- 36
  • 97 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 96 (a)
ManyToMany
chicken
(Gallus gallus)
Aves IMPDH2 35
  • 80.35 (n)
  • 94.94 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia impdh2 35
  • 78.6 (n)
  • 93.19 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.2636 35
impdh2 35
  • 76.98 (n)
  • 91.25 (a)
impdh2 36
  • 91 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13891 35
fruit fly
(Drosophila melanogaster)
Insecta ras 37
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea T22D1.3 36
  • 53 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IMD1 36
  • 55 (a)
ManyToMany
IMD2 36
  • 60 (a)
ManyToMany
IMD3 36
  • 61 (a)
ManyToMany
IMD4 36
  • 61 (a)
ManyToMany
IMD2 38
soybean
(Glycine max)
eudicotyledons Gma.898 35
barley
(Hordeum vulgare)
Liliopsida Hv.10632 35
rice
(Oryza sativa)
Liliopsida Os.4738 35
wheat
(Triticum aestivum)
Liliopsida Ta.3649 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4205 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8181 36
  • 57 (a)
OneToMany
Species with no ortholog for IMPDH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for IMPDH2 Gene

ENSEMBL:
Gene Tree for IMPDH2 (if available)
TreeFam:
Gene Tree for IMPDH2 (if available)

Paralogs for IMPDH2 Gene

Paralogs for IMPDH2 Gene

Selected SIMAP similar genes for IMPDH2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IMPDH2: view

Variants for IMPDH2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IMPDH2 Gene

P12268-IMDH2_HUMAN
Genetic variants in the IMPDH2 gene may account for the large inter-individual variability in enzyme activity, immunosuppressive efficacy and side effects in transplant recipients receiving mycophenolic acid

Sequence variations from dbSNP and Humsavar for IMPDH2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1049818 -- 49,024,386(-) CTTTT(C/T)TGAAA reference, synonymous-codon
rs1134122 -- 49,024,299(+) CCCAC(A/C)TGTCT downstream-variant-500B
rs3891187 -- 49,024,225(-) CTCAG(C/G)GCCCG downstream-variant-500B
rs3929973 -- 49,027,317(-) GGGTG(G/T)TTTGG intron-variant
rs3929974 -- 49,025,454(-) GAGGT(A/C)CGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IMPDH2 Gene

Variant ID Type Subtype PubMed ID
nsv876764 CNV Loss 21882294

Relevant External Links for IMPDH2 Gene

HapMap Linkage Disequilibrium report
IMPDH2
Human Gene Mutation Database (HGMD)
IMPDH2

Disorders for IMPDH2 Gene

(3) Novoseek inferred disease relationships for IMPDH2 Gene

Disease -log(P) Hits PubMed IDs
cancer 8.66 4
leukemia 0 1
tumors 0 2

Relevant External Links for IMPDH2

Genetic Association Database (GAD)
IMPDH2
Human Genome Epidemiology (HuGE) Navigator
IMPDH2
genes like me logo Genes that share disorders with IMPDH2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for IMPDH2 Gene

Publications for IMPDH2 Gene

  1. A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity. (PMID: 17496727) Wang J. … Burckart G.J. (Pharmacogenet. Genomics 2007) 3 4 23 25 48
  2. An inosine 5'-monophosphate dehydrogenase 2 single-nucleotide polymorphism impairs the effect of mycophenolic acid. (PMID: 19770842) Winnicki W. … Sengoelge G. (Pharmacogenomics J. 2010) 3 23 48
  3. Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals. (PMID: 20045992) Kudo M. … Hiratsuka M. (Drug Metab. Pharmacokinet. 2009) 3 23 48
  4. Two distinct cDNAs for human IMP dehydrogenase. (PMID: 1969416) Natsumeda Y. … Suzuki K. (J. Biol. Chem. 1990) 2 3 4
  5. Interpopulation variation frequency of human inosine 5'-monophosphate dehydrogenase type II (IMPDH2) genetic polymorphisms. (PMID: 18976158) Mohamed M.F. … Langaee T.Y. (Genet. Test. 2008) 3 23 48

Products for IMPDH2 Gene

Sources for IMPDH2 Gene

Back to Top

Content