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IMPA2 Gene

protein-coding   GIFtS: 67
GCID: GC18P011981

Inositol(Myo)-1(Or 4)-Monophosphatase 2

  See IMPA2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inositol(Myo)-1(Or 4)-Monophosphatase 21 2     Inositol Monophosphatase 22
Myo-Inositol Monophosphatase A22 3     Inositol Monophosphatase 2 Variant 12
IMP 22 3     Inositol Monophosphatase 2 Variant 22
IMPase 22 3     IMP.18P3
EC 3.1.3.253 8     Inositol-1(Or 4)-Monophosphatase 23
Inosine Monophosphatase 22     

External Ids:    HGNC: 60511   Entrez Gene: 36132   Ensembl: ENSG000001414017   OMIM: 6059225   UniProtKB: O147323   

Export aliases for IMPA2 gene to outside databases

Previous GC identifers: GC18P012247 GC18P012038 GC18P011971


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IMPA2 Gene:
This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol
monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with
susceptibility to bipolar disorder. (provided by RefSeq, Jan 2011)

GeneCards Summary for IMPA2 Gene:
IMPA2 (inositol(myo)-1(or 4)-monophosphatase 2) is a protein-coding gene. Diseases associated with IMPA2 include bipolar disorder, and schizophrenia. GO annotations related to this gene include inositol monophosphate 3-phosphatase activity and protein homodimerization activity. An important paralog of this gene is IMPA1.

UniProtKB/Swiss-Prot: IMPA2_HUMAN, O14732
Function: Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate,
beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium
Li(+) action in brain

Gene Wiki entry for IMPA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the IMPA2 gene promoter:
         TBP   HOXA3   C/EBPalpha   Arnt   N-Myc   Zic1   ZIC2/Zic2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIMPA2 promoter sequence
   Search Chromatin IP Primers for IMPA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IMPA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.2   Ensembl cytogenetic band:  18p11.21   HGNC cytogenetic band: 18p11.2

IMPA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IMPA2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P011981:  view genomic region     (about GC identifiers)

Start:
11,981,024 bp from pter      End:
12,030,885 bp from pter
Size:
49,862 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IMPA2_HUMAN, O14732 (See protein sequence)
Recommended Name: Inositol monophosphatase 2  
Size: 288 amino acids; 31321 Da
Cofactor: Magnesium
Subunit: Homodimer
5 PDB 3D structures from and Proteopedia for IMPA2:
2CZH (3D)        2CZI (3D)        2CZK (3D)        2DDK (3D)        2FVZ (3D)    
Secondary accessions: B0YJ29 Q9UJT3
Alternative splicing: 2 isoforms:  O14732-1   O14732-2   

Explore the universe of human proteins at neXtProt for IMPA2: NX_O14732

Explore proteomics data for IMPA2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys184
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for IMPA2 (O14732)
     GAFCNGQ  NFVHRFP  DLVTETD  GAADAYY 


    See IMPA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055029.1  
    ENSEMBL proteins: 
     ENSP00000465416   ENSP00000269159   ENSP00000466059   ENSP00000372867   ENSP00000465938  
     ENSP00000464767   ENSP00000464754  
    Reactome Protein details: O14732

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: IMPase 2
    Inositol monophosphatase

    4 InterPro protein domains:
     IPR020550 Inositol_monophosphatase_CS
     IPR000760 Inositol_monophosphatase
     IPR020583 Inositol_monoP_metal-BS
     IPR020552 Inositol_monoPase_Li-sen

    Graphical View of Domain Structure for InterPro Entry O14732

    ProtoNet protein and cluster: O14732

    UniProtKB/Swiss-Prot: IMPA2_HUMAN, O14732
    Similarity: Belongs to the inositol monophosphatase family


    Find genes that share domains with IMPA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IMPA2_HUMAN, O14732
    Function: Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate,
    beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium
    Li(+) action in brain
    Catalytic activity: Myo-inositol phosphate + H(2)O = myo-inositol + phosphate
    Enzyme regulation: Inhibited by high Li(+) and restricted Mg(2+) concentrations
    Biophysicochemical properties: Kinetic parameters: KM=5 mM for myo-inositol 1-monophosphate; pH dependence:
    Optimum pH is 7.5-8.0;
    Induction: Repressed by Li(+)

         Genatlas biochemistry entry for IMPA2:
    inositol(myo)-1(or 4)-monophosphatase 2,widely expressed in adult and fetal tissues but minimally in brain

         Enzyme Number (IUBMB): EC 3.1.3.251 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008934inositol monophosphate 1-phosphatase activity IDA17068342
    GO:0042803protein homodimerization activity IPI17068342
    GO:0046872metal ion binding IEA--
    GO:0052832inositol monophosphate 3-phosphatase activity IEA--
    GO:0052833inositol monophosphate 4-phosphatase activity IEA--
         
    Find genes that share ontologies with IMPA2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IMPA2:
     Decreased focal adhesion (FA)  

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Impa2):
     behavior/neurological  nervous system  no phenotypic analysis  normal  renal/urinary system 

    Find genes that share phenotypes with IMPA2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Impa2tm1.2Tohn for IMPA2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IMPA2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IMPA2

    miRNA
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    miRTarBase miRNAs that target IMPA2:
    hsa-mir-484 (MIRT042179)

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    Selected qRT-PCR Assays for microRNAs that regulate IMPA2 (see all 14):
    hsa-miR-4324 hsa-miR-137 hsa-miR-92a hsa-miR-4251 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-33a
    SwitchGear 3'UTR luciferase reporter plasmidIMPA2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton3
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA17068342
    GO:0005829cytosol TAS--

    Find genes that share ontologies with IMPA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IMPA2 About    
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    myo-inositol biosynthesis0.00
    Phosphatidylinositol signaling system0.61
    D-myo-inositol (1,4,5)-trisphosphate degradation0.00
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Inositol phosphate metabolism (REACTOME)
    Inositol phosphate metabolism0.59
    Synthesis of IP2, IP, and Ins in the cytosol0.00


    Find genes that share SuperPaths with IMPA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for IMPA2
        D-myo-inositol (1,4,5)-trisphosphate degradation
    myo-inositol biosynthesis
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism

    1 Reactome Pathway for IMPA2
        Synthesis of IP2, IP, and Ins in the cytosol


    3 Kegg Pathways  (Kegg details for IMPA2):
        Inositol phosphate metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system

    UniProtKB/Swiss-Prot: IMPA2_HUMAN, O14732
    Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IMPA2
    Interactions:

        Search GeneGlobe Interaction Network for IMPA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IMPA2 (O147322, 3 ENSP000002691594) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF14Q929562, 3, ENSP000003479484MINT-8274500 I2D: score=2 STRING: ENSP00000347948
    HERPUD1Q150113, ENSP000003003024I2D: score=3 STRING: ENSP00000300302
    IMPA1ENSP000004085264STRING: ENSP00000408526
    INPP1ENSP000003254234STRING: ENSP00000325423
    INPP4AENSP000000743044STRING: ENSP00000074304
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006021inositol biosynthetic process IEA--
    GO:0006796phosphate-containing compound metabolic process TAS9322233
    GO:0007165signal transduction TAS9322233
    GO:0043647inositol phosphate metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with IMPA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IMPA2

    9 HMDB Compounds for IMPA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    1D-myo-Inositol 3-phosphateD-myo-Inositol 3-phosphate (see all 9)2831-74-5--
    D-Myo-inositol 4-phosphate1D-myo-inositol 4-monophosphate (see all 7)46495-39-0--
    Inositol phosphate1D-myo-Inositol 1-monophosphate (see all 4)15421-51-9--
    LithiumLi (see all 5)7439-93-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Myo-inositol 1-phosphate1-(dihydrogen phosphate) DL-myo-Inositol (see all 8)573-35-3--
    MyoinositolMI (see all 11)87-89-8--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for IMPA2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Lithium-- 7439-93-2targetinhibitor17251911 17068342 16841073

    4 Novoseek inferred chemical compound relationships for IMPA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 84 21 10822344 (3), 15505643 (2), 11317223 (2), 10822345 (1) (see all 13)
    inositol monophosphate 77.7 1 17340635 (1)
    lithium 74 21 15505643 (3), 15504365 (2), 10822344 (1), 17068342 (1) (see all 7)
    calcium 1.92 3 18922242 (1), 11673796 (1), 17340635 (1)



    Find genes that share compounds with IMPA2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IMPA2 gene: 
    NM_014214.2  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588752 ENST00000589238 ENST00000269159(uc002kqp.2 uc021uhq.1)
    ENST00000590107 ENST00000383376(uc010dlb.2) ENST00000590138 ENST00000588927
    ENST00000588863 ENST00000588167 ENST00000586230 ENST00000589374
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    hsa-miR-4324 hsa-miR-137 hsa-miR-92a hsa-miR-4251 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-33a
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    Selected AceView cDNA sequences (see all 269):

    BM854579 CR594604 BG698388 AI636703 BE222751 AA595049 BG164583 BM927957 
    AI015559 BC017176 CR623705 BF819323 BQ644649 CR622241 F28856 BG742941 
    CB243598 BI060040 BU177364 BX284019 BQ933557 BI755999 CB243545 BM856907 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IMPA2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                      -                       -                                 
    SP2:              -     -     -           -                       -                                 
    SP3:                    -     -           -                       -                                 
    SP4:                                      -           -           -                                 
    SP5:                                      -                                                         


    ECgene alternative splicing isoforms for IMPA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IMPA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGTGGCTC
    IMPA2 Expression
    About this image


    IMPA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Kidney (Urinary System)
             Metanephros
     
     Adipose (Muscoskeletal System)
             Thoracic Perivascular Adipose
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Colon (Gastrointestinal Tract)
    IMPA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IMPA2 Protein Expression
        Custom PCR Arrays for IMPA2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IMPA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for IMPA2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Impa21 , 5 inositol (myo)-1(or 4)-monophosphatase 21, 5 87.38(n)1
    90.97(a)1
      18 (39.92 cM)5
    1146631  NM_053261.21  NP_444491.11 
     672892235 
    chicken
    (Gallus gallus)
    Aves IMPA21 inositol(myo)-1(or 4)-monophosphatase 2 77.2(n)
    84.03(a)
      421032  XM_419118.3  XP_419118.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.150172 Transcribed sequence with moderate similarity to protein more 76.17(n)    AL872125.2 
    zebrafish
    (Danio rerio)
    Actinopterygii impa21 inositol(myo)-1(or 4)-monophosphatase 2 65.93(n)
    69.74(a)
      553595  NM_001020572.1  NP_001018408.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG93913
    CG93891
    dephosphorylation myo-inositol-1(or
    4)-monophosphatase3
    CG93891
    46(a)
    (best of 5)3
    51.44(n)1
    47.24(a)1
      78C33
    403471  NM_141038.31  NP_649295.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F13G3.53 myo-inositol-1-monophosphatase 43(a)   I(7309454-7311033)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes INM16
    INM26
    Inositol monophosphatase, involved in biosynthesis...
    Inositol monophosphatase, involved in biosynthesis...
    27(a)
    27(a)
    many ↔ many
    many ↔ many
    VIII(197398-198285) YHR046C
    IV(1035995-1036873) YDR287W


    ENSEMBL Gene Tree for IMPA2 (if available)
    TreeFam Gene Tree for IMPA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IMPA2 gene
    IMPA12  
    1 SIMAP similar gene for IMPA2 using alignment to 13 protein entries:     IMPA2_HUMAN (see all proteins):
    IMPA1

    Find genes that share paralogs with IMPA2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IMPA2 (see all 1303)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs670318551,2
    C--11934162(+) CTGTC-/TT    
       
    /TTTT
    TTTTT
    1 -- us2k11NA 2
    rs772399441,2
    C--11939580(+) AAAAAA/CAACAA 1 -- int10--------
    rs746488111,2
    C--11939581(+) AAAACA/TACAAA 1 -- int10--------
    rs2000084681,2
    C--11941576(-) GCAAAA/GCAAAA 1 -- int10--------
    rs1412506981,2
    C--11957396(+) GTCTC-/AAAA  
            
    AAAAA
    1 -- int10--------
    rs1996528921,2
    C--11963870(+) CTCCA-/CTGGGC 1 -- int10--------
    rs3772979331,2
    C--11964253(+) GCTGG-/ATTCC 
            
    TTCCC
    1 -- int10--------
    rs1422366981,2
    --11966666(+) TTAGCG/TGCCCC 1 -- us2k10--------
    rs749505211,2
    F--11966687(+) GGTGGG/CAGGCA 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1878498761,2
    --11966695(+) GCAGGA/GCAATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IMPA2 (11981024 - 12030885 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for IMPA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663207CNV Deletion23128226
    nsv909387CNV Loss21882294
    nsv909385CNV Loss21882294
    nsv909386CNV Loss21882294
    nsv528699CNV Loss19592680
    esv9600CNV Gain19470904
    nsv909384CNV Gain21882294
    dgv3385n71CNV Gain21882294
    dgv1011e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): IMPA2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IMPA2
    DNA2.0 Custom Variant and Variant Library Synthesis for IMPA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605922    OMIM disorders: --

    2 diseases for IMPA2:    
    About MalaCards
    bipolar disorder    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for IMPA2:
    Schizophrenia

    Find genes that share disorders with IMPA2           About GenesLikeMe

    4 Novoseek inferred disease relationships for IMPA2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bipolar disorder 74.1 27 17251911 (5), 10822344 (2), 15505643 (2), 17340635 (2) (see all 10)
    seizures febrile 71.6 6 17388992 (1), 17340635 (1), 17068342 (1), 15557493 (1)
    mood disorders 51.4 1 11317223 (1)
    schizophrenia 34 8 11317223 (3), 17340635 (1), 17068342 (1)

    Genetic Association Database (GAD): IMPA2
    Human Genome Epidemiology (HuGE) Navigator: IMPA2 (8 documents)

    Export disorders for IMPA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IMPA2 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with IMPA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. (PubMed id 17068342)1, 2, 7, 9 Ohnishi T.... Yoshikawa T. (J. Biol. Chem. 2007)
    2. A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. (PubMed id 9322233)1, 2, 3, 9 Yoshikawa T....Detera-Wadleigh S.D. (Mol. Psychiatry 1997)
    3. Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures. (PubMed id 17340635)1, 2, 9 Arai R.... Yokoyama S. (Proteins 2007)
    4. A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription. (PubMed id 17251911)1, 7, 9 Ohnishi T....Yoshikawa T. (Neuropsychopharmacology 2007)
    5. A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic- depressive patients. (PubMed id 10822345)1, 2, 9 Sjoeholt G....Steen V.M. (Mol. Psychiatry 2000)
    6. Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients. (PubMed id 17388992)1, 4, 9 Blair M.A....Hedera P. (Eur. J. Neurol. 2007)
    7. Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples. (PubMed id 11317223)1, 4, 9 Yoshikawa T....Detera-Wadleigh S.D. (Mol. Psychiatry 2001)
    8. Association study of myo-inositol monophosphatase 2 (IMPA2) polymorphisms with bipolar affective disorder and response to lithium treatment. (PubMed id 15505643)1, 4, 9 Dimitrova A....Kirov G. (Pharmacogenomics J. 2005)
    9. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    10. Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke. (PubMed id 19910543)1, 4 Ding H....Wang D.W. ( a journal of cerebral circulation 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3613 HGNC: 6051 AceView: IMPA2 Ensembl:ENSG00000141401 euGenes: HUgn3613
    ECgene: IMPA2 Kegg: 3613 H-InvDB: IMPA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IMPA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IMPA2 gene:
    Search GeneIP for patents involving IMPA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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