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Aliases for IMPA2 Gene

Aliases for IMPA2 Gene

  • Inositol Monophosphatase 2 2 3 5
  • EC 3.1.3.25 4 61
  • Inositol(Myo)-1(Or 4)-Monophosphatase 2 2
  • Inositol-1(Or 4)-Monophosphatase 2 4
  • Myo-Inositol Monophosphatase A2 4
  • Myo-Inositol Monophosphatase 2 2
  • IMPase 2 4
  • IMP.18P 4
  • IMP 2 4

External Ids for IMPA2 Gene

Previous GeneCards Identifiers for IMPA2 Gene

  • GC18P012247
  • GC18P012038
  • GC18P011971

Summaries for IMPA2 Gene

Entrez Gene Summary for IMPA2 Gene

  • This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]

GeneCards Summary for IMPA2 Gene

IMPA2 (Inositol Monophosphatase 2) is a Protein Coding gene. Diseases associated with IMPA2 include Bipolar Disorder and Whipple Disease. Among its related pathways are Inositol phosphate metabolism (KEGG) and Inositol phosphate metabolism (REACTOME). GO annotations related to this gene include protein homodimerization activity and inositol monophosphate 3-phosphatase activity. An important paralog of this gene is IMPA1.

UniProtKB/Swiss-Prot for IMPA2 Gene

  • Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.

Gene Wiki entry for IMPA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMPA2 Gene

Genomics for IMPA2 Gene

Regulatory Elements for IMPA2 Gene

Enhancers for IMPA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G012038 1.5 Ensembl ENCODE dbSUPER 23.4 +57.9 57873 1.6 ARID4B SIN3A ZNF2 ZNF48 YY1 GLIS2 ZNF143 KLF13 DEK ZNF263 IMPA2 ENSG00000267733 MPPE1 CHMP1B ENSG00000267480 ENSG00000267247 ENSG00000266995
GH18G012007 1.3 ENCODE dbSUPER 21.3 +30.1 30087 6.5 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 TCF12 SLC30A9 ZNF121 IMPA2 MPPE1 CHMP1B ENSG00000267733 LOC101927511 ENSG00000266955 ENSG00000267480
GH18G011993 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.1 +14.1 14128 4.2 ARID4B SIN3A ZNF143 DEK SP5 REST ZNF592 KAT8 NFIL3 SSRP1 IMPA2 MPPE1 CHMP1B ENSG00000266955 ENSG00000267480
GH18G011953 1.2 Ensembl ENCODE 19.4 -24.8 -24776 4.7 FOXA2 ARNT ARID4B ZNF48 CBX5 FOS SP5 PPARG KAT8 ZNF592 IMPA2 MPPE1 CHMP1B LOC101927511 GC18P012428
GH18G012032 0.9 Ensembl ENCODE dbSUPER 25.5 +52.2 52182 0.8 JUND FOS IMPA2 MPPE1 CHMP1B ENSG00000267480 ENSG00000266995
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IMPA2 on UCSC Golden Path with GeneCards custom track

Promoters for IMPA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000100915 475 2201 FOXA2 MLX CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for IMPA2 Gene

Chromosome:
18
Start:
11,981,025 bp from pter
End:
12,030,886 bp from pter
Size:
49,862 bases
Orientation:
Plus strand

Genomic View for IMPA2 Gene

Genes around IMPA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IMPA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IMPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMPA2 Gene

Proteins for IMPA2 Gene

  • Protein details for IMPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14732-IMPA2_HUMAN
    Recommended name:
    Inositol monophosphatase 2
    Protein Accession:
    O14732
    Secondary Accessions:
    • B0YJ29
    • Q9UJT3

    Protein attributes for IMPA2 Gene

    Size:
    288 amino acids
    Molecular mass:
    31321 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for IMPA2 Gene

    Alternative splice isoforms for IMPA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IMPA2 Gene

Selected DME Specific Peptides for IMPA2 Gene

O14732:
  • DLVTETD
  • GAADAYY
  • GAFCNGQ
  • NFVHRFP

Post-translational modifications for IMPA2 Gene

  • Ubiquitination at isoforms=2184
  • Modification sites at PhosphoSitePlus

Domains & Families for IMPA2 Gene

Gene Families for IMPA2 Gene

Graphical View of Domain Structure for InterPro Entry

O14732

UniProtKB/Swiss-Prot:

IMPA2_HUMAN :
  • Belongs to the inositol monophosphatase family.
Family:
  • Belongs to the inositol monophosphatase family.
genes like me logo Genes that share domains with IMPA2: view

Function for IMPA2 Gene

Molecular function for IMPA2 Gene

GENATLAS Biochemistry:
inositol(myo)-1(or 4)-monophosphatase 2,widely expressed in adult and fetal tissues but minimally in brain
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=5 mM for myo-inositol 1-monophosphate {ECO:0000269 PubMed:17068342}; pH dependence: Optimum pH is 7.5-8.0. {ECO:0000269 PubMed:17068342};
UniProtKB/Swiss-Prot CatalyticActivity:
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by high Li(+) and restricted Mg(2+) concentrations.
UniProtKB/Swiss-Prot Function:
Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.
UniProtKB/Swiss-Prot Induction:
Repressed by Li(+).

Enzyme Numbers (IUBMB) for IMPA2 Gene

Gene Ontology (GO) - Molecular Function for IMPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008934 inositol monophosphate 1-phosphatase activity TAS,IEA --
GO:0016787 hydrolase activity IEA --
GO:0042803 protein homodimerization activity IDA 17068342
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with IMPA2: view
genes like me logo Genes that share phenotypes with IMPA2: view

Animal Models for IMPA2 Gene

MGI Knock Outs for IMPA2:

Animal Model Products

  • Taconic Biosciences Mouse Models for IMPA2

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IMPA2 Gene

Localization for IMPA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IMPA2 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IMPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17068342
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IMPA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IMPA2 Gene

Pathways & Interactions for IMPA2 Gene

genes like me logo Genes that share pathways with IMPA2: view

UniProtKB/Swiss-Prot O14732-IMPA2_HUMAN

  • Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.

Gene Ontology (GO) - Biological Process for IMPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006020 inositol metabolic process IBA --
GO:0006021 inositol biosynthetic process IEA --
GO:0006796 phosphate-containing compound metabolic process TAS 9322233
GO:0007165 signal transduction TAS 9322233
GO:0043647 inositol phosphate metabolic process TAS --
genes like me logo Genes that share ontologies with IMPA2: view

No data available for SIGNOR curated interactions for IMPA2 Gene

Drugs & Compounds for IMPA2 Gene

(6) Drugs for IMPA2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lithium Approved Pharma Target, inhibitor 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Magnesium Nutra 0

(7) Additional Compounds for IMPA2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1D-myo-Inositol 3-phosphate
  • 1D-Myo-Inositol 3-monophosphate
  • 1L-Myo-Inositol 1-phosphate
  • D-Myo-Inositol 3-monophosphate
  • D-Myo-Inositol 3-phosphate
  • Inositol 3-monophosphate
2831-74-5
D-Myo-inositol 4-phosphate
  • 1D-Myo-inositol 4-monophosphate
  • 1D-Myo-inositol 4-phosphate
  • D-Myo-inositol-4-phosphate
  • D-Myoinositol 4-phosphate
  • Inositol 4-phosphate
46495-39-0
Inositol phosphate
  • 1D-Myo-Inositol 1-monophosphate
  • 1D-Myo-Inositol 1-phosphate
  • D-Myo-Inositol-1-Phosphate
  • Inositol 1-monophosphate
15421-51-9
Myoinositol
  • cis-1,2,3,5-trans-4,6-Cyclohexanehexol
  • i-Inositol
  • Iso-Inositol
  • Meat sugar
  • Meso-Inositol
87-89-8
Myo-inositol 1-phosphate
  • 1-(Dihydrogen phosphate) DL-myo-Inositol
  • 1-(Dihydrogen phosphate) myo-Inositol
  • DL-myo-Inositol 1-phosphate
  • Myo-Inositol 1-monophosphate
  • Myo-Inositol 1-phosphate
573-35-3
genes like me logo Genes that share compounds with IMPA2: view

Transcripts for IMPA2 Gene

Unigene Clusters for IMPA2 Gene

Inositol(myo)-1(or 4)-monophosphatase 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IMPA2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for IMPA2 Gene

GeneLoc Exon Structure for
IMPA2
ECgene alternative splicing isoforms for
IMPA2

Expression for IMPA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IMPA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IMPA2 Gene

This gene is overexpressed in Pancreas (x7.0), Muscle - Skeletal (x5.8), and Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for IMPA2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.7), Tonsil (11.3), Oral epithelium (6.9), and Pancreas (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IMPA2 Gene



NURSA nuclear receptor signaling pathways regulating expression of IMPA2 Gene:

IMPA2

SOURCE GeneReport for Unigene cluster for IMPA2 Gene:

Hs.743311

Evidence on tissue expression from TISSUES for IMPA2 Gene

  • Skin(4.4)
  • Kidney(2.5)
  • Muscle(2.3)
  • Pancreas(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with IMPA2: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IMPA2 Gene

Orthologs for IMPA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IMPA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IMPA2 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia IMPA2 34 35
  • 88.98 (n)
rat
(Rattus norvegicus)
Mammalia Impa2 34
  • 88.08 (n)
mouse
(Mus musculus)
Mammalia Impa2 34 16 35
  • 87.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IMPA2 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IMPA2 35
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IMPA2 34 35
  • 82.75 (n)
chicken
(Gallus gallus)
Aves IMPA2 34 35
  • 77.2 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia impa2 34
  • 71.48 (n)
Str.15017 34
zebrafish
(Danio rerio)
Actinopterygii impa2 34 35
  • 65.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9389 36 34
  • 51.44 (n)
CG9391 36
  • 46 (a)
CG17029 36 35
  • 36 (a)
CG17026 36 35
  • 35 (a)
CG17027 36 35
  • 34 (a)
CG17028 35
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F13G3.5 36
  • 43 (a)
ttx-7 35
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes INM1 35
  • 27 (a)
ManyToMany
INM2 35
  • 27 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06022 34
  • 49.22 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToMany
Species where no ortholog for IMPA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IMPA2 Gene

ENSEMBL:
Gene Tree for IMPA2 (if available)
TreeFam:
Gene Tree for IMPA2 (if available)

Paralogs for IMPA2 Gene

Paralogs for IMPA2 Gene

genes like me logo Genes that share paralogs with IMPA2: view

Variants for IMPA2 Gene

Sequence variations from dbSNP and Humsavar for IMPA2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000050585 -- 12,029,389(+) AATTA(C/T)AGGCA intron-variant
rs1000221246 -- 12,028,241(+) GGAGG(A/C)AGCCT intron-variant
rs1000222223 -- 11,997,396(+) AGTTA(C/T)GGCTA intron-variant
rs1000236548 -- 12,021,708(+) GATGG(A/G)GCTTC intron-variant
rs1000268738 -- 11,982,844(+) GGAGG(G/T)GTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IMPA2 Gene

Variant ID Type Subtype PubMed ID
esv2663207 CNV deletion 23128226
esv2758713 CNV loss 17122850
esv3641826 CNV loss 21293372
esv3893075 CNV gain 25118596
esv9600 CNV gain 19470904
nsv1071430 CNV deletion 25765185
nsv1129331 OTHER inversion 24896259
nsv1153637 OTHER inversion 26484159
nsv528699 CNV loss 19592680
nsv576495 CNV loss 21841781

Variation tolerance for IMPA2 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IMPA2 Gene

Human Gene Mutation Database (HGMD)
IMPA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IMPA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IMPA2 Gene

Disorders for IMPA2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for IMPA2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bipolar disorder
  • bipolar depression
whipple disease
  • intestinal lipodystrophy
mood disorder
  • episodic mood disorder
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search IMPA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IMPA2

Genetic Association Database (GAD)
IMPA2
Human Genome Epidemiology (HuGE) Navigator
IMPA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IMPA2
genes like me logo Genes that share disorders with IMPA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IMPA2 Gene

Publications for IMPA2 Gene

  1. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. (PMID: 17068342) Ohnishi T. … Yoshikawa T. (J. Biol. Chem. 2007) 3 4 22 25 64
  2. A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. (PMID: 9322233) Yoshikawa T. … Detera-Wadleigh S.D. (Mol. Psychiatry 1997) 2 3 4 22 64
  3. A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription. (PMID: 17251911) Ohnishi T. … Yoshikawa T. (Neuropsychopharmacology 2007) 3 22 25 64
  4. Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients. (PMID: 17388992) Blair M.A. … Hedera P. (Eur. J. Neurol. 2007) 3 22 46 64
  5. Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures. (PMID: 17340635) Arai R. … Yokoyama S. (Proteins 2007) 3 4 22 64

Products for IMPA2 Gene

Sources for IMPA2 Gene

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