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IMPA1 Gene

protein-coding   GIFtS: 71
GCID: GC08M082569

Inositol(Myo)-1(Or 4)-Monophosphatase 1


(Previous symbol: IMPA)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inositol(Myo)-1(Or 4)-Monophosphatase 11 2     IMPase 12 3
IMPA1 2 3     EC 3.1.3.253 8
Inositol-1(Or 4)-Monophosphatase 12 3     IMP2
Lithium-Sensitive Myo-Inositol Monophosphatase A12 3     Inositol Monophosphatase 12
IMP 12 3     

External Ids:    HGNC: 60501   Entrez Gene: 36122   Ensembl: ENSG000001337317   OMIM: 6020645   UniProtKB: P292183   

Export aliases for IMPA1 gene to outside databases

Previous GC identifers: GC08M081447 GC08M082618 GC08M082293 GC08M082620 GC08M082732 GC08M078058


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IMPA1 Gene:
This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a
precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction
via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can
also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate,
glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of
lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for
phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to
treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
A pseudogene of this gene is also present on chromosome 8q21.13. (provided by RefSeq, Nov 2009)

GeneCards Summary for IMPA1 Gene:
IMPA1 (inositol(myo)-1(or 4)-monophosphatase 1) is a protein-coding gene. Diseases associated with IMPA1 include chronic intestinal vascular insufficiency, and bipolar disorder. GO annotations related to this gene include inositol monophosphate 1-phosphatase activity and protein homodimerization activity. An important paralog of this gene is IMPA2.

UniProtKB/Swiss-Prot: IMPA1_HUMAN, P29218
Function: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and
polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use
myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate,
scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate,
and 2'-AMP as substrates

Gene Wiki entry for IMPA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the IMPA1 gene promoter:
         TBP   Evi-1   Egr-4   RORalpha1   c-Rel   POU2F1   NRF-2   POU2F1a   TFIID   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIMPA1 promoter sequence
   Search Chromatin IP Primers for IMPA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IMPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.13-q21.3   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.1-q21.3

IMPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IMPA1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M082569:  view genomic region     (about GC identifiers)

Start:
82,569,151 bp from pter      End:
82,598,928 bp from pter
Size:
29,778 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IMPA1_HUMAN, P29218 (See protein sequence)
Recommended Name: Inositol monophosphatase 1  
Size: 277 amino acids; 30189 Da
Cofactor: Magnesium
Subunit: Homodimer
Selected PDB 3D structures from and Proteopedia for IMPA1 (see all 9):
1AWB (3D)        1IMA (3D)        1IMB (3D)        1IMC (3D)        1IMD (3D)        1IME (3D)    
Secondary accessions: B2R733 B4DLN3 B7Z6Q4 J3KQT7 Q9UK71
Alternative splicing: 3 isoforms:  P29218-1   P29218-2   P29218-3   (No experimental confirmation available. Ref.4 (BAH13340) sequence is in conflict in position: 17:Q->R)

Explore the universe of human proteins at neXtProt for IMPA1: NX_P29218

Explore proteomics data for IMPA1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys145
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for IMPA1 (P29218) (see all 7)
     GAFCNGQ  NFVHRFP  FIGEESVA  DGTTNFVH 


    See IMPA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138350.1  NP_001138351.1  NP_005527.1  

    ENSEMBL proteins: 
     ENSP00000256108   ENSP00000311803   ENSP00000408526   ENSP00000429735   ENSP00000428812  
     ENSP00000429322   ENSP00000430283   ENSP00000428425   ENSP00000430081   ENSP00000429516  
     ENSP00000428594  
    Reactome Protein details: P29218

    IMPA1 Human Recombinant Protein Products:

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    Novus Biologicals IMPA1 Proteins
    Novus Biologicals IMPA1 Lysates
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    ProSpec Recombinant Protein for IMPA1
    Cloud-Clone Corp. Proteins for IMPA1

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    LSBio Antibodies in human, mouse, rat for IMPA1

    IMPA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for IMPA1
    Cloud-Clone Corp. CLIAs for IMPA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: IMPase 1
    Inositol monophosphatase

    4 InterPro protein domains:
     IPR020550 Inositol_monophosphatase_CS
     IPR000760 Inositol_monophosphatase
     IPR020583 Inositol_monoP_metal-BS
     IPR020552 Inositol_monoPase_Li-sen

    Graphical View of Domain Structure for InterPro Entry P29218

    ProtoNet protein and cluster: P29218

    1 Blocks protein domain: IPB000146 Inositol phosphatase/fructose-1,6-bisphosphatase

    UniProtKB/Swiss-Prot: IMPA1_HUMAN, P29218
    Similarity: Belongs to the inositol monophosphatase family


    IMPA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IMPA1_HUMAN, P29218
    Function: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and
    polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use
    myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate,
    scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate,
    and 2'-AMP as substrates
    Catalytic activity: Myo-inositol phosphate + H(2)O = myo-inositol + phosphate
    Enzyme regulation: Inhibited by Li(+)
    Biophysicochemical properties: pH dependence: Optimum pH is 7.0-7.5;

         Genatlas biochemistry entry for IMPA1:
    myo-inositol monophosphatase 1,putatively involved in response to lithium treatment

         Enzyme Number (IUBMB): EC 3.1.3.251 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008934inositol monophosphate 1-phosphatase activity IMP1377913
    GO:0042802identical protein binding IPI16189514
    GO:0042803protein homodimerization activity IPI17068342
    GO:0046872metal ion binding IEA--
    GO:0052832inositol monophosphate 3-phosphatase activity IEA--
         
    IMPA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IMPA1:
     Actin fiber cells 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Impa1):
     behavior/neurological  mortality/aging  nervous system 

    IMPA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Impa1tm1Lex for IMPA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IMPA1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IMPA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IMPA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target IMPA1:
    hsa-mir-215-5p (MIRT024884), hsa-mir-34a-5p (MIRT006254), hsa-mir-27a-3p (MIRT050020), hsa-mir-192-5p (MIRT026629), hsa-mir-132-3p (MIRT021823), hsa-mir-365a-3p (MIRT044020)

    Block miRNA regulation of human, mouse, rat IMPA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IMPA1 (see all 10):
    hsa-miR-3671 hsa-miR-433 hsa-miR-203 hsa-miR-607 hsa-miR-4307 hsa-miR-16-2* hsa-miR-302f hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidIMPA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IMPA1
    Predesigned siRNA for gene silencing in human, mouse, rat IMPA1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IMPA1

    Clone
    Products:
         
    OriGene clones in human, mouse for IMPA1 (see all 17)
    OriGene ORF clones in mouse, rat for IMPA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IMPA1 (NM_005536)
    Sino Biological Human cDNA Clone for IMPA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IMPA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMPA1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IMPA1 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IMPA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IMPA1_HUMAN, P29218: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion4
    nucleus4
    chloroplast1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA1377913
    GO:0005739mitochondrion ----
    GO:0005829cytosol TAS--

    IMPA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IMPA1 About    
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    myo-inositol biosynthesis0.00
    Phosphatidylinositol signaling system0.61
    D-myo-inositol (1,4,5)-trisphosphate degradation0.00
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Inositol phosphate metabolism (REACTOME)
    Inositol phosphate metabolism0.59
    Synthesis of IP2, IP, and Ins in the cytosol0.00
    4Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for IMPA1
        Integrated Breast Cancer Pathway
    D-myo-inositol (1,4,5)-trisphosphate degradation
    myo-inositol biosynthesis
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism


    1 Reactome Pathway for IMPA1
        Synthesis of IP2, IP, and Ins in the cytosol


    3 Kegg Pathways  (Kegg details for IMPA1):
        Inositol phosphate metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system

    UniProtKB/Swiss-Prot: IMPA1_HUMAN, P29218
    Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2


    IMPA1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IMPA1
    Interactions:

        Search GeneGlobe Interaction Network for IMPA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IMPA1 (P292181, 2, 3 ENSP000004085264) via UniProtKB, MINT, STRING, and/or I2D (see all 56)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    IMPA1P292181, 2EBI-752410,EBI-752410 MINT-68471
    CALB1P059373, ENSP000002654314I2D: score=2 STRING: ENSP00000265431
    PGLSO953363I2D: score=5 
    ARPC3O151453I2D: score=1 
    CETN3O151823I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006021inositol biosynthetic process IEA--
    GO:0006661phosphatidylinositol biosynthetic process IMP1377913
    GO:0006796phosphate-containing compound metabolic process IMP1377913
    GO:0007165signal transduction IMP1377913
    GO:0043647inositol phosphate metabolic process TAS--

    IMPA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IMPA1

    9 HMDB Compounds for IMPA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    1D-myo-Inositol 3-phosphateD-myo-Inositol 3-phosphate (see all 9)2831-74-5--
    D-Myo-inositol 4-phosphate1D-myo-inositol 4-monophosphate (see all 7)46495-39-0--
    Inositol phosphate1D-myo-Inositol 1-monophosphate (see all 4)15421-51-9--
    LithiumLi (see all 5)7439-93-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Myo-inositol 1-phosphate1-(dihydrogen phosphate) DL-myo-Inositol (see all 8)573-35-3--
    MyoinositolMI (see all 11)87-89-8--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for IMPA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Lithium-- 7439-93-2targetinhibitor17158747 20027624 16965760 16874097 17251911 17068342
    L-Myo-Inositol-1-Phosphate-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for IMPA1 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 93.4 270 11914086 (7), 9647837 (6), 15006136 (4), 11170378 (4) (see all 97)
    lithium 88.5 115 15093960 (4), 9462881 (3), 8035344 (3), 8883919 (2) (see all 56)
    di-myo-inositol-1,1'-phosphate 86.8 3 9647837 (1), 11170378 (1)
    inositol monophosphate 79.7 6 11914086 (2), 12587191 (1), 9322233 (1), 17725819 (1)
    phosphatidylinositol 65.4 31 7482796 (3), 8883919 (1), 12849935 (1), 17725819 (1) (see all 12)
    phosphoinositide 61.6 11 12975484 (1), 1377913 (1), 19383941 (1), 9536026 (1) (see all 7)
    galactose-1-phosphate 59.3 11 9462881 (4), 12450779 (3), 9647837 (1), 17643331 (1)
    glycogen 57.3 12 19442155 (2), 19015387 (1), 18715951 (1), 17316163 (1) (see all 10)
    valproate 52.4 3 12479670 (1), 15136794 (1)
    magnesium 48.5 8 17725819 (3), 9647837 (2), 17068342 (2), 15136794 (1)



    IMPA1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IMPA1 gene (3 alternative transcripts): 
    NM_001144878.1  NM_001144879.1  NM_005536.3  

    Unigene Cluster for IMPA1:

    Inositol(myo)-1(or 4)-monophosphatase 1
    Hs.656694  [show with all ESTs]
    Unigene Representative Sequence: NM_001144878
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256108(uc011lfq.1 uc003ych.2 uc011lfr.1) ENST00000311489
    ENST00000449740 ENST00000523942 ENST00000518188 ENST00000523710 ENST00000519964
    ENST00000521360 ENST00000520065 ENST00000521979 ENST00000522997 ENST00000518202
    ENST00000519816
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat IMPA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IMPA1 (see all 10):
    hsa-miR-3671 hsa-miR-433 hsa-miR-203 hsa-miR-607 hsa-miR-4307 hsa-miR-16-2* hsa-miR-302f hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidIMPA1 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 3): IMPA1 (NM_005536)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMPA1
    Primer
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    OriGene qPCR primer pairs and template standards for IMPA1
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      QuantiFast Probe-based Assays in human, mouse, rat IMPA1

    Additional mRNA sequence: 

    AF042729.2 AK297078.1 AK300750.1 AK312823.1 BC008381.1 BC009565.1 X66922.1 

    17 DOTS entries:

    DT.445367  DT.100754313  DT.100754312  DT.100754308  DT.92440351  DT.100663855  DT.100754309  DT.405439 
    DT.121485423  DT.92440352  DT.121485416  DT.121485408  DT.121485434  DT.95273653  DT.97781609  DT.97809016 
    DT.97802244 

    Selected AceView cDNA sequences (see all 223):

    F05906 BG528895 AA406379 BI460905 AL553170 AU108085 H59218 AU142381 
    BU683659 AU140070 AU108083 AI934967 BU078773 AF042729 AW298497 BU170296 
    AU100304 BC009565 CA841642 NM_005536 F08887 AA713489 AU143775 BU684167 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IMPA1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
    SP1:        -     -                                   -                                 
    SP2:        -                                                                           
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for IMPA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IMPA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAACTT
    IMPA1 Expression
    About this image


    IMPA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Eye (Sensory Organs)
             Lens
    IMPA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IMPA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656694
        Custom PCR Arrays for IMPA1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IMPA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IMPA1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Impa11 , 5 inositol (myo)-1(or 4)-monophosphatase 11, 5 83.57(n)1
    86.59(a)1
      3 (2.61 cM)5
    559801  NM_018864.51  NP_061352.21 
     103135405 
    chicken
    (Gallus gallus)
    Aves IMPA11 inositol(myo)-1(or 4)-monophosphatase 1 76.69(n)
    80.07(a)
      420199  XM_418310.4  XP_418310.3 
    lizard
    (Anolis carolinensis)
    Reptilia IMPA16
    inositol(myo)-1(or 4)-monophosphatase 1
    80(a)
    1 ↔ 1
    4(24432470-24450759)
    African clawed frog
    (Xenopus laevis)
    Amphibia impa1-prov2 inositol(myo)-1(or 4)-monophosphatase 1 77.13(n)    BC054268.1 
    zebrafish
    (Danio rerio)
    Actinopterygii impa11 inositol(myo)-1(or 4)-monophosphatase 1 69.33(n)
    67.64(a)
      437018  NM_001002745.1  NP_001002745.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG93911 , 3 dephosphorylation myo-inositol-1(or
    4)-monophosphatase3
    CG93911
    46(a)
    (best of 5)3
    51.18(n)1
    46.47(a)1
      78C33
    403461  NM_141037.51  NP_649294.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F13G3.53
    ttx-71
    myo-inositol-1-monophosphatase3
    ttx-71
    45(a)3
    52.13(n)1
    47.74(a)1
      I(7309454-7311033)3
    1724771  NM_001128981.21  NP_001122453.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes INM2(YDR287W)4
    INM21
    Inositol monophosphatase, involved in biosynthesis more4
    INM21
    52.74(n)1
    44.13(a)1
      4(1035995-1036873)4
    8518811, 4  NP_010573.31  NP_010573.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VTC41 VTC4 50.57(n)
    41.06(a)
      821206  NM_111155.2  NP_186936.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g05870001 Os03g0587000 51.94(n)
    45.74(a)
      4333347  NM_001057109.1  NP_001050574.1 


    ENSEMBL Gene Tree for IMPA1 (if available)
    TreeFam Gene Tree for IMPA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IMPA1 gene
    IMPA22  
    Selected SIMAP similar genes for IMPA1 using alignment to 9 protein entries:     IMPA1_HUMAN (see all proteins) (see all similar genes):
    ZNF737    ZNF547    FKBP3    TMEM14B    ZNF738    ZNF74
    UTY    AURA2    SHANK2    ZNF212    ZNF564    ZNF83
    IMPA2    NF2    ZNF28    ZNF546    CHID1    ZNF468

    IMPA1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for IMPA1
    PGOHUM00000256860 PGOHUM00000257193


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IMPA1 (see all 858)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs585501591,2
    C--82579968(+) CTGAG-/TGAG  
            
    GAACA
    3 -- int10--------
    rs598540081,2
    C--82590008(+) ATATA-/ACATTC 3 -- int10--------
    rs1136246151,2
    F--82599858(+) TTAAAC/AACACA 3 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1489025591,2
    --82667155(+) ACCAGA/CAACAA 3 -- ds50010--------
    rs1877420251,2
    --82667169(+) CTAAAA/GGAGTT 3 -- ds50010--------
    rs1914612191,2
    --82667192(+) CTAGGA/GTGGGA 3 -- ds50010--------
    rs1842544761,2
    --82667446(+) AATACA/CTATCC 3 -- ds50010--------
    rs1897791431,2
    --82667472(+) CTTAGC/GATTGT 3 -- ds50010--------
    rs1434675881,2
    --82667476(+) GCATTC/GTAAAC 3 -- ds50010--------
    rs625122801,2
    C,F--82667485(+) ACCAAT/CTCTAA 3 -- ds50012Minor allele frequency- C:0.07NA 122

    HapMap Linkage Disequilibrium report for IMPA1 (82569151 - 82598928 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for IMPA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737230CNV Deletion23290073
    esv2665097CNV Deletion23128226
    esv1774004CNV Insertion17803354
    nsv831368CNV Gain17160897
    nsv465721CNV Gain19166990
    nsv831369CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IMPA1
    DNA2.0 Custom Variant and Variant Library Synthesis for IMPA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602064    OMIM disorders: --

    19 diseases for IMPA1:    
    About MalaCards
    chronic intestinal vascular insufficiency    bipolar disorder    galactosemia    ischemic heart disease
    mood disorder    febrile seizures    schizophrenia    down syndrome
    huntington's disease    dementia    pneumonia    tuberculosis
    neuroblastoma    hepatocellular carcinoma    ovarian cancer    malaria
    breast cancer    cerebritis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for IMPA1:
    Chronic intestinal vascular insufficiency     Galactosemia

    IMPA1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for IMPA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bipolar disorder 79.5 18 7482796 (3), 14699425 (2), 15809430 (1), 9322233 (1) (see all 13)
    mood disorders 52.3 1 11673796 (1)
    manic episode 43.5 1 15093960 (1)
    erectile dysfunction 37 8 16281836 (2), 12846094 (2), 17918321 (1), 15560162 (1) (see all 5)
    mania 18.4 1 16542185 (1)
    schizophrenia 1.51 1 9777174 (1)


    Export disorders for IMPA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IMPA1 gene, integrated from 10 sources (see all 140):
    (articles sorted by number of sources associating them with IMPA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. (PubMed id 17068342)1, 2, 7, 9 Ohnishi T.... Yoshikawa T. (J. Biol. Chem. 2007)
    2. cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme. (PubMed id 1377913)1, 2, 3, 9 McAllister G.... Ragan C.I. (Biochem. J. 1992)
    3. Genomic structure and chromosomal localization of a human myo- inositol monophosphatase gene (IMPA). (PubMed id 9339367)1, 2, 9 Sjoeholt G....Steen V.M. (Genomics 1997)
    4. Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catalysis. (PubMed id 8068621)1, 2, 9 Bone R.... Atack J.R. (Biochemistry 1994)
    5. Structure of inositol monophosphatase, the putative target of lithium therapy. (PubMed id 1332026)1, 2, 9 Bone R.... Atack J.R. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The contribution of lysine-36 to catalysis by human myo-inositol monophosphatase. (PubMed id 8718889)1, 2 Ganzhorn A.J....Rondeau J.-M. (Biochemistry 1996)
    8. Inositol monophosphatase activity in normal, Down syndrome and dementia of the Alzheimer type CSF. (PubMed id 11959401)1, 9 Atack J.R. and Schapiro M.B. (Neurobiol. Aging 2002)
    9. Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder. (PubMed id 14699425)1, 9 SjA...Steen V.M. (Mol. Psychiatry 2004)
    10. Myo-inositol monophosphatase is an activated target of calbindin D28k. (PubMed id 12176979)1, 9 Berggard T....Linse S. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3612 HGNC: 6050 AceView: IMPA1 Ensembl:ENSG00000133731 euGenes: HUgn3612
    ECgene: IMPA1 Kegg: 3612 H-InvDB: IMPA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IMPA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IMPA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IMPA1 gene:
    Search GeneIP for patents involving IMPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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