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GIFtS

IMPA1 Gene

protein-coding   GIFtS: 65
GCID: GC08M082569

inositol(myo)-1(or 4)-monophosphatase 1


(Previous symbol: IMPA)
 Explore 18 diseases affiliated with
IMPA1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IMPA1    

Aliases
for IMPA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inositol(Myo)-1(Or 4)-Monophosphatase 11 2     IMPase 12 3
IMPA1 2 3     EC 3.1.3.253 8
Inositol-1(Or 4)-Monophosphatase 12 3     IMP2
Lithium-Sensitive Myo-Inositol Monophosphatase A12 3     Inositol Monophosphatase 12
IMP 12 3     

External Ids:    HGNC: 60501   Entrez Gene: 36122   Ensembl: ENSG000001337317   OMIM: 6020645   UniProtKB: P292183   

Export aliases for IMPA1 gene to outside databases

Previous GC identifers: GC08M081447 GC08M082618 GC08M082293 GC08M082620 GC08M082732 GC08M078058


Summaries
for IMPA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IMPA1:
This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor
of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the
production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use
myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate,
glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows
magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of
inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain
the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing
results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on
chromosome 8q21.13. (provided by RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: IMPA1_HUMAN, P29218
Function: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and
polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use
myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate,
glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates

Gene Wiki entry for IMPA1


Genomic Views
for IMPA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IMPA1 gene promoter:
         TBP   Evi-1   Egr-4   RORalpha1   c-Rel   POU2F1   NRF-2   POU2F1a   TFIID   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IMPA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IMPA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IMPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.13-q21.3   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.1-q21.3

IMPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IMPA1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M082569:  view genomic region     (about GC identifiers)

Start:
 82,569,151 bp from pter      End:
 82,598,928 bp from pter
Size:
 29,778 bases      Orientation:
 minus strand

Proteins
for IMPA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IMPA1_HUMAN, P29218 (See protein sequence)
Recommended Name: Inositol monophosphatase 1  
Size: 277 amino acids; 30189 Da
Cofactor: Magnesium
Subunit: Homodimer
Subcellular location: Cytoplasm
6/9 PDB 3D structures from and Proteopedia for IMPA1 (see all 9):
1AWB (3D)        1IMA (3D)        1IMB (3D)        1IMC (3D)        1IMD (3D)        1IME (3D)    
Secondary accessions: B2R733 B4DLN3 B7Z6Q4 J3KQT7 Q9UK71
Alternative splicing: 3 isoforms:  P29218-1   P29218-2   P29218-3   (No experimental confirmation available. Ref.4 (BAH13340) sequence is in conflict in position: 17:Q->R)

Explore the universe of human proteins at neXtProt for IMPA1: NX_P29218

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P29218

    • 4/7 DME Specific Peptides for IMPA1 (P29218) (see all 7)
     GAFCNGQ  NFVHRFP  FIGEESVA  DGTTNFVH 

    IMPA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138350.1  NP_001138351.1  NP_005527.1  

    ENSEMBL proteins: 
     ENSP00000256108   ENSP00000311803   ENSP00000408526   ENSP00000429735   ENSP00000428812  
     ENSP00000429322   ENSP00000430283   ENSP00000428425   ENSP00000430081   ENSP00000429516  
     ENSP00000428594  
    Reactome Protein details: P29218
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: IMPA1
    OriGene Protein Over-expression Lysate (see all 2): IMPA1
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    Novus Biologicals IMPA1 Proteins
    Novus Biologicals IMPA1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for IMPA1
    Uscn Proteins for IMPA1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA17068342
    GO:0005739mitochondrion IDA--
    GO:0030424axon ----


    IMPA1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for IMPA1

    Protein Domains /
    Families
    for IMPA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IMPA1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020550 Inositol_monophosphatase_CS
     IPR000760 Inositol_monophosphatase
     IPR020583 Inositol_monoP_metal-BS
     IPR020552 Inositol_monoPase_Li-sen

    Graphical View of Domain Structure for InterPro Entry P29218

    ProtoNet protein and cluster: P29218

    1 Blocks protein family: IPB000146 Inositol phosphatase/fructose-1,6-bisphosphatase

    UniProtKB/Swiss-Prot: IMPA1_HUMAN, P29218
    Similarity: Belongs to the inositol monophosphatase family


    Function
    for IMPA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IMPA1_HUMAN, P29218
    Function: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and
    polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use
    myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate,
    glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates
    Catalytic activity: Myo-inositol phosphate + H(2)O = myo-inositol + phosphate
    Enzyme regulation: Inhibited by Li(+)
    Biophysicochemical properties: pH dependence: Optimum pH is 7.0-7.5;

         Genatlas biochemistry entry for IMPA1:
    myo-inositol monophosphatase 1,putatively involved in response to lithium treatment

    Enzyme Number (IUBMB): EC 3.1.3.251 2

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate IMPA1 (see all 10):
    hsa-miR-3671 hsa-miR-433 hsa-miR-203 hsa-miR-607 hsa-miR-4307 hsa-miR-16-2* hsa-miR-302f hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: IMPA1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: IMPA1
    OriGene siRNA: IMPA1
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IMPA1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IMPA1 (see all 6)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): IMPA1 (NM_005536)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMPA1 

    Cell Line
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    Search LifeMap BioReagents cell lines for IMPA1

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008934inositol monophosphate 1-phosphatase activity IMP1377913
    GO:0042803protein homodimerization activity IPI17068342
    GO:0046872metal ion binding IEA--
    GO:0052832inositol monophosphate 3-phosphatase activity IEA--
    GO:0052833inositol monophosphate 4-phosphatase activity IEA--


    IMPA1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for IMPA1:
     Actin fiber cells 

    Animal Models:
         Mouse knock-out Impa1tm1Lex for IMPA1
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Impa1):
     behavior/neurological  mortality/aging  nervous system 

    IMPA1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IMPA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    		superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.75
    		Synthesis of IP2, IP, and Ins in the cytosol0.24
    		D-myo-inositol (1,4,5)-trisphosphate degradation0.40
    2Inositol phosphate metabolism
    		Inositol phosphate metabolism1.00
    		Phosphatidylinositol signaling system0.59
    3Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    4Integrated Breast Cancer Pathway
    		Integrated Breast Cancer Pathway1.00
    5myo-inositol biosynthesis
    		myo-inositol biosynthesis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4 BioSystems Pathways for IMPA1 
        Integrated Breast Cancer Pathway
    D-myo-inositol (1,4,5)-trisphosphate degradation
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
    myo-inositol biosynthesis

    3        Reactome Pathways for IMPA1
        Synthesis of IP2, IP, and Ins in the cytosol
    Metabolism
    Inositol phosphate metabolism


    3         Kegg Pathways  (Kegg details for IMPA1):
        Inositol phosphate metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system

    UniProtKB/Swiss-Prot: IMPA1_HUMAN, P29218
    Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2


    IMPA1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IMPA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/41 Interacting proteins for IMPA1 (P292181, 2, 3 ENSP000004085264) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    IMPA1P292181, 2EBI-752410,EBI-752410 MINT-68471
    CALB1P059373, ENSP000002654314I2D: score=2 STRING: ENSP00000265431
    PGLSO953363I2D: score=5 
    ARPC3O151453I2D: score=1 
    CETN3O151823I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006021inositol biosynthetic process IEA--
    GO:0006661phosphatidylinositol biosynthetic process IMP1377913
    GO:0006796phosphate-containing compound metabolic process IMP1377913
    GO:0007165signal transduction IMP1377913
    GO:0010226response to lithium ion ----


    IMPA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IMPA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IMPA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IMPA1

    9 HMDB Compounds for IMPA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    1D-myo-Inositol 3-phosphateD-myo-Inositol 3-phosphate (see all 9)2831-74-5--
    D-Myo-inositol 4-phosphate1D-myo-inositol 4-monophosphate (see all 7)46495-39-0--
    Inositol phosphate1D-myo-Inositol 1-monophosphate (see all 4)15421-51-9--
    LithiumLi (see all 5)7439-93-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Myo-inositol 1-phosphate1-(dihydrogen phosphate) DL-myo-Inositol (see all 8)573-35-3--
    MyoinositolMI (see all 11)87-89-8--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for IMPA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Lithium-- 7439-93-2targetinhibitor17158747 16965760 16874097 17251911 17068342
    L-Myo-Inositol-1-Phosphate-- --target--17139284 17016423

    10/20 Novoseek chemical compound relationships for IMPA1 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 93.4 270 11914086 (7), 9647837 (6), 15006136 (4), 11170378 (4) (see all 97)
    lithium 88.5 115 15093960 (4), 9462881 (3), 8035344 (3), 8883919 (2) (see all 56)
    di-myo-inositol-1,1'-phosphate 86.8 3 9647837 (1), 11170378 (1)
    inositol monophosphate 79.7 6 11914086 (2), 12587191 (1), 9322233 (1), 17725819 (1)
    phosphatidylinositol 65.4 31 7482796 (3), 8883919 (1), 12849935 (1), 17725819 (1) (see all 12)
    phosphoinositide 61.6 11 12975484 (1), 1377913 (1), 19383941 (1), 9536026 (1) (see all 7)
    galactose-1-phosphate 59.3 11 9462881 (4), 12450779 (3), 9647837 (1), 17643331 (1)
    glycogen 57.3 12 19442155 (2), 19015387 (1), 18715951 (1), 17316163 (1) (see all 10)
    valproate 52.4 3 12479670 (1), 15136794 (1)
    magnesium 48.5 8 17725819 (3), 9647837 (2), 17068342 (2), 15136794 (1)

    Search CenterWatch for drugs/clinical trials and news about IMPA1 

    Transcripts
    for IMPA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IMPA1 gene (3 alternative transcripts): 
    NM_001144878.1  NM_001144879.1  NM_005536.3  

    Unigene Cluster for IMPA1:

    Inositol(myo)-1(or 4)-monophosphatase 1
    Hs.656694  [show with all ESTs]
    Unigene Representative Sequence: NM_001144878
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256108(uc011lfq.1 uc003ych.2 uc011lfr.1) ENST00000311489
    ENST00000449740 ENST00000523942 ENST00000518188 ENST00000523710 ENST00000519964
    ENST00000521360 ENST00000520065 ENST00000521979 ENST00000522997 ENST00000518202
    ENST00000519816

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    hsa-miR-3671 hsa-miR-433 hsa-miR-203 hsa-miR-607 hsa-miR-4307 hsa-miR-16-2* hsa-miR-302f hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: IMPA1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF042729.2 AK297078.1 AK300750.1 AK312823.1 BC008381.1 BC009565.1 X66922.1 

    17 DOTS entries:

    DT.445367  DT.100754313  DT.100754312  DT.100754308  DT.100663855  DT.100754309  DT.405439  DT.92440351 
    DT.121485423  DT.92440352  DT.121485416  DT.121485408  DT.121485434  DT.95273653  DT.97781609  DT.97809016 
    DT.97802244 

    24/223 AceView cDNA sequences (see all 223):

    AU108083 H59217 BG779260 BQ215654 BM456197 AA406379 BU684167 AU140070 
    CR606000 BI460905 AU100304 AF042729 AU143775 BU683659 BU170296 BU169473 
    AI342745 AW471319 F05906 AA713489 F08887 AI570888 BU950124 AW298497 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IMPA1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
    SP1:        -     -                                   -                                 
    SP2:        -                                                                           
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for IMPA1

    Expression
    for IMPA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IMPA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATAAAACTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See IMPA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IMPA1

    SOURCE GeneReport for Unigene cluster: Hs.656694
        SABiosciences Custom PCR Arrays for IMPA1
    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for IMPA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for IMPA1 gene from 11/34 species (see all 34)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Impa11 , 5 inositol (myo)-1(or 4)-monophosphatase 11, 5 83.57(n)1
    86.59(a)1    		   3 (2.61 cM)5
    559801  NM_018864.51  NP_061352.21 
     103135405 
    chicken
    (Gallus gallus)    		 Aves IMPA11 inositol(myo)-1(or 4)-monophosphatase 1 78.06(n)
    82.91(a)    		   420199  XM_418310.3  XP_418310.2 
    lizard
    (Anolis carolinensis)    		 Reptilia IMPA16
    		 --
    		 80(a)
    		 1 ↔ 1
    		 4(24438136-24447569)
    African clawed frog
    (Xenopus laevis)    		 Amphibia impa1-prov2 inositol(myo)-1(or 4)-monophosphatase 1 77.13(n)    BC054268.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii impa11 inositol(myo)-1(or 4)-monophosphatase 1 69.33(n)
    67.64(a)    		   437018  NM_001002745.1  NP_001002745.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG93911 , 3 dephosphorylation myo-inositol-1(or
    4)-monophosphatase3
    CG93911    		 46(a)
    (best of 5)3
    51.74(n)1
    47.76(a)1    		   78C33
    403461  NM_141037.41  NP_649294.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea F13G3.53
    ttx-71    		 myo-inositol-1-monophosphatase3
    Protein TTX-71    		 45(a)3
    52.13(n)1
    47.74(a)1    		   I(7309454-7311033)3
    1724771  NM_001128981.11  NP_001122453.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes INM2(YDR287W)4
    INM21    		 Inositol monophosphatase, involved in biosynthesis more4
    Inm2p1    		 52.74(n)1
    44.13(a)1    		   4(1035995-1036873)4
    8518811, 4  NP_010573.31  NP_010573.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons VTC41 inositol-phosphate phosphatase 50.44(n)
    41.06(a)    		   821206  NM_111155.2  NP_186936.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g05870001 hypothetical protein 51.94(n)
    45.74(a)    		   4333347  NM_001057109.1  NP_001050574.1 


    ENSEMBL Gene Tree for IMPA1 (if available)
    TreeFam Gene Tree for IMPA1 (if available) 

    Paralogs
    for IMPA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IMPA1 gene
    IMPA22  
    14 SIMAP similar genes for IMPA1 using alignment to 9 protein entries:     IMPA1_HUMAN (see all proteins):
    FKBP3    TMEM14B    ZNF74    UTY    AURA2    SHANK2
    ZNF212    ZNF564    IMPA2    NF2    CHID1    TCEB1
    FAM3A    APOD

    IMPA1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for IMPA1
    PGOHUM00000256860 PGOHUM00000257193


    Genomic Variants
    for IMPA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/720 NCBI SNPs in IMPA1 are shown (see all 720)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs625122801,2
    		C,--78058882(+) ACCAAT/CTCTAA 3 -- ds50012Minor allele frequency- C:0.07NA 122
    rs780504421,2
    		--78058891(+) AAGAAT/CGGCTG 3 -- ds50011Minor allele frequency- C:0.01WA 118
    rs119873561,2
    		C,F,H,--78059620(+) CAAGAC/TACTGT 3 -- ut316Minor allele frequency- T:0.02NS EA NA WA 506
    rs119944811,2
    		C,F,H,--78059697(+) ATATCA/GTGGCC 3 -- ut319Minor allele frequency- G:0.09NS EA NA CSA WA 776
    rs117767571,2
    		C,F,H--78060025(+) ATGATC/TGTCTT 3 -- ut31 ese37Minor allele frequency- T:0.01NS EA NA 588
    rs169094711,2
    		C,F,H,--78060400(+) TCCAGC/TGGCAA 3 -- ut31 ese316Minor allele frequency- T:0.06NA NS EA WA CSA 1446
    rs2047981,2
    		H--78060425(-) TAGTCT/GTCTTA 3 -- ut31 ese37Minor allele frequency- G:0.00MN NS EA NA 594
    rs788918461,2
    		C,F,--78060727(+) ATGGTA/GACGTG 3 -- ut312Minor allele frequency- G:0.08WA NA 238
    rs101051651,2
    		H--78061392(+) AGGCTG/ACCTTA 3 -- ut314Minor allele frequency- A:0.00NS EA 420
    rs1128966921,2
    		--78061595(+) TACTAC/TGGTCA 3 -- int11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for IMPA1 (82569151 - 82598928 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IMPA1: --

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    Disorders / Diseases
    for IMPA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IMPA1 for disorders           About GeneDecksing

    OMIM gene information: 602064    OMIM disorders: --

    18 diseases for IMPA1:    About MalaCards
    bipolar disorder    chronic intestinal vascular insufficiency    febrile seizures    ischemic heart disease
    galactosemia    seizures    down syndrome    huntington's disease
    hepatocellular carcinoma    neurodegeneration    schizophrenia    dementia
    pneumonia    neuroblastoma    tuberculosis    carcinoma
    neuronitis    mycobacterium tuberculosis

    2 diseases from the University of Copenhagen DISEASES database for IMPA1:
    Chronic intestinal vascular insufficiency     Galactosemia

    6 Novoseek disease relationships for IMPA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bipolar disorder 79.5 18 7482796 (3), 14699425 (2), 15809430 (1), 9322233 (1) (see all 13)
    mood disorders 52.3 1 11673796 (1)
    manic episode 43.5 1 15093960 (1)
    erectile dysfunction 37 8 16281836 (2), 12846094 (2), 17918321 (1), 15560162 (1) (see all 5)
    mania 18.4 1 16542185 (1)
    schizophrenia 1.51 1 9777174 (1)


    Export disorders for IMPA1 gene to outside databases

    Publications
    for IMPA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IMPA1 gene, integrated from 9 sources (see all 137):
    (articles sorted by number of sources associating them with IMPA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. (PubMed id 17068342)1, 2, 7, 9 Ohnishi T....Yoshikawa T. (2007)
    2. cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme. (PubMed id 1377913)1, 2, 3, 9 McAllister G.... Ragan C.I. (1992)
    3. Genomic structure and chromosomal localization of a human myo- inositol monophosphatase gene (IMPA). (PubMed id 9339367)1, 2, 9 Sjoeholt G....Steen V.M. (1997)
    4. Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catalysis. (PubMed id 8068621)1, 2, 9 Bone R.... Atack J.R. (1994)
    5. Structure of inositol monophosphatase, the putative target of lithium therapy. (PubMed id 1332026)1, 2, 9 Bone R.... Atack J.R. (1992)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The contribution of lysine-36 to catalysis by human myo-inositol monophosphatase. (PubMed id 8718889)1, 2 Ganzhorn A.J....Rondeau J.-M. (1996)
    8. Inositol monophosphatase activity in normal, Down syndrome and dementia of the Alzheimer type CSF. (PubMed id 11959401)1, 9 Atack J.R. and Schapiro M.B. (2002)
    9. Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder. (PubMed id 14699425)1, 9 Sjoholt G....Steen V.M. (2004)
    10. Myo-inositol monophosphatase is an activated target of calbindin D28k. (PubMed id 12176979)1, 9 Berggard T....Linse S. (2002)

    External Searches for IMPA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IMPA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3612 HGNC: 6050 AceView: IMPA1 Ensembl:ENSG00000133731 euGenes: HUgn3612
    ECgene: IMPA1 Kegg: 3612 H-InvDB: IMPA1

    Other Databases showing IMPA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IMPA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IMPA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IMPA1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for IMPA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IMPA1 gene:
    Search GeneIP for patents involving IMPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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