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Aliases for IMP4 Gene

Aliases for IMP4 Gene

  • IMP4, U3 Small Nucleolar Ribonucleoprotein 2 3
  • BXDC4 3 4 6
  • Brix Domain-Containing Protein 4 3 4
  • U3 SnoRNP Protein IMP4 3 4
  • IMP4, U3 Small Nucleolar Ribonucleoprotein, Homolog (Yeast) 2
  • IMP4, U3 Small Nucleolar Ribonucleoprotein, Homolog 3
  • U3 Small Nucleolar Ribonucleoprotein Protein IMP4 3
  • U3 SnoRNP Protein 4 Homolog 3

External Ids for IMP4 Gene

Summaries for IMP4 Gene

Entrez Gene Summary for IMP4 Gene

  • IMP4 forms a ternary complex with IMP3 (MIM 612980) and MPP10 (MPHOSPHO10; MIM 605503) that interacts with U3 small nucleolar RNA (snoRNA), which is required for the early cleavage steps in pre-rRNA processing (Granneman et al., 2003 [PubMed 12655004]).[supplied by OMIM, Aug 2009]

GeneCards Summary for IMP4 Gene

IMP4 (IMP4, U3 Small Nucleolar Ribonucleoprotein) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes.

UniProtKB/Swiss-Prot for IMP4 Gene

  • Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Gene Wiki entry for IMP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMP4 Gene

Genomics for IMP4 Gene

Genomic Location for IMP4 Gene

130,342,225 bp from pter
130,347,810 bp from pter
5,586 bases
Plus strand

Genomic View for IMP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IMP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMP4 Gene

Regulatory Elements for IMP4 Gene

Proteins for IMP4 Gene

  • Protein details for IMP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U3 small nucleolar ribonucleoprotein protein IMP4
    Protein Accession:
    Secondary Accessions:
    • Q3ZTT3

    Protein attributes for IMP4 Gene

    291 amino acids
    Molecular mass:
    33757 Da
    Quaternary structure:
    • Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.

neXtProt entry for IMP4 Gene

Proteomics data for IMP4 Gene at MOPED

Post-translational modifications for IMP4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys183

Other Protein References for IMP4 Gene

No data available for DME Specific Peptides for IMP4 Gene

Domains for IMP4 Gene

Protein Domains for IMP4 Gene


Suggested Antigen Peptide Sequences for IMP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Brix domain.:
    • Q96G21
genes like me logo Genes that share domains with IMP4: view

No data available for Gene Families for IMP4 Gene

Function for IMP4 Gene

Molecular function for IMP4 Gene

UniProtKB/Swiss-Prot Function: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Gene Ontology (GO) - Molecular Function for IMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12655004
GO:0030515 snoRNA binding IBA --
GO:0042134 rRNA primary transcript binding IBA --
genes like me logo Genes that share ontologies with IMP4: view

Phenotypes for IMP4 Gene

genes like me logo Genes that share phenotypes with IMP4: view

miRNA for IMP4 Gene

miRTarBase miRNAs that target IMP4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IMP4 Gene

Localization for IMP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IMP4 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for IMP4 Gene COMPARTMENTS Subcellular localization image for IMP4 gene
Compartment Confidence
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 12655004
GO:0030529 ribonucleoprotein complex --
GO:0032040 small-subunit processome IBA --
GO:0034457 Mpp10 complex IBA --
genes like me logo Genes that share ontologies with IMP4: view

Pathways for IMP4 Gene

genes like me logo Genes that share pathways with IMP4: view

Pathways by source for IMP4 Gene

1 KEGG pathway for IMP4 Gene

Gene Ontology (GO) - Biological Process for IMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing NAS 12655004
genes like me logo Genes that share ontologies with IMP4: view

Transcripts for IMP4 Gene

Unigene Clusters for IMP4 Gene

IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IMP4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: - - - - -
SP9: - - -

Relevant External Links for IMP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IMP4 Gene

mRNA expression in normal human tissues for IMP4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IMP4 Gene

SOURCE GeneReport for Unigene cluster for IMP4 Gene Hs.91579

genes like me logo Genes that share expressions with IMP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IMP4 Gene

Orthologs for IMP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IMP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IMP4 35
  • 98.74 (n)
  • 98.28 (a)
IMP4 36
  • 98 (a)
(Bos Taurus)
Mammalia IMP4 35
  • 87.74 (n)
  • 95.71 (a)
IMP4 36
  • 96 (a)
(Canis familiaris)
Mammalia IMP4 35
  • 87.64 (n)
  • 94.91 (a)
IMP4 36
  • 95 (a)
(Mus musculus)
Mammalia Imp4 35
  • 87.62 (n)
  • 97.86 (a)
Imp4 16
Imp4 36
  • 98 (a)
(Monodelphis domestica)
Mammalia IMP4 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia IMP4 36
  • 80 (a)
(Rattus norvegicus)
Mammalia Imp4 35
  • 86.31 (n)
  • 97.86 (a)
(Gallus gallus)
Aves IMP4 35
  • 63.9 (n)
  • 63.9 (a)
IMP4 36
  • 64 (a)
(Anolis carolinensis)
Reptilia IMP4 36
  • 85 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6114 35
tropical clawed frog
(Silurana tropicalis)
Amphibia imp4 35
  • 74.17 (n)
  • 78.57 (a)
Str.1165 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2996 35
(Danio rerio)
Actinopterygii Dr.19345 35
imp4 35
  • 67.38 (n)
  • 76.43 (a)
imp4 36
  • 77 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003890 35
  • 58.9 (n)
  • 60.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11920 35
  • 56.2 (n)
  • 53.79 (a)
CG11920 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea CELE_ZK795.3 35
  • 56 (n)
  • 60.66 (a)
ZK795.3 36
  • 59 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER430W 35
  • 55.43 (n)
  • 51.48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IMP4 35
  • 49.15 (n)
  • 52.19 (a)
IMP4 36
  • 52 (a)
IMP4 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E07833g 35
  • 49.51 (n)
  • 51.85 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons IMP4 35
  • 53.38 (n)
  • 51.09 (a)
(Oryza sativa)
Liliopsida Os08g0155000 35
  • 56.7 (n)
  • 57.69 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04243 35
  • 51.59 (n)
  • 46.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC19A8.07c 35
  • 50.69 (n)
  • 51.7 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8068 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6162 36
  • 63 (a)
Species with no ortholog for IMP4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IMP4 Gene

Gene Tree for IMP4 (if available)
Gene Tree for IMP4 (if available)

Paralogs for IMP4 Gene

Selected SIMAP similar genes for IMP4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IMP4: view

No data available for Paralogs for IMP4 Gene

Variants for IMP4 Gene

Sequence variations from dbSNP and Humsavar for IMP4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2292850 -- 130,344,965(-) GTCTT(G/T)CCCCA intron-variant
rs2292851 -- 130,344,829(-) GACAA(A/G)GGCAT intron-variant
rs11542413 -- 130,345,790(+) TCATC(A/G)TCAGC missense, reference
rs11542414 -- 130,346,476(+) ACACT(C/T)ACCAC utr-variant-3-prime
rs11542415 -- 130,346,062(+) GATGA(C/T)AGCCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IMP4 Gene

Variant ID Type Subtype PubMed ID
nsv459274 CNV Loss 19166990
dgv1247e1 CNV Complex 17122850
esv2751826 CNV Gain 17911159
dgv1250e1 CNV Complex 17122850
nsv428403 CNV Loss 18775914
dgv4305n71 CNV Gain 21882294
dgv4306n71 CNV Gain 21882294
nsv7327 OTHER Inversion 18451855
dgv4307n71 CNV Gain 21882294
nsv520559 CNV Gain+Loss 19592680
nsv875084 CNV Gain+Loss 21882294
dgv4308n71 CNV Gain 21882294
nsv470485 CNV Gain 18288195
nsv818080 CNV Gain 17921354
dgv475n27 CNV Gain 19166990
essv2399 CNV CNV 17122850
dgv4309n71 CNV Gain 21882294
nsv459341 CNV Loss 19166990
nsv875097 CNV Loss 21882294
nsv875098 CNV Gain 21882294
dgv4310n71 CNV Gain 21882294

Relevant External Links for IMP4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IMP4 Gene

Disorders for IMP4 Gene

No disorders were found for IMP4 Gene.

No data available for UniProtKB/Swiss-Prot for IMP4 Gene

Publications for IMP4 Gene

  1. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. (PMID: 12655004) Granneman S. … Pruijn G.J.M. (Nucleic Acids Res. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  4. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for IMP4 Gene

Sources for IMP4 Gene

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