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Aliases for IMP4 Gene

Aliases for IMP4 Gene

  • IMP4 Homolog, U3 Small Nucleolar Ribonucleoprotein 2 3 5
  • IMP4, U3 Small Nucleolar Ribonucleoprotein 2 3
  • Brix Domain-Containing Protein 4 3 4
  • U3 SnoRNP Protein IMP4 3 4
  • BXDC4 3 4
  • IMP4, U3 Small Nucleolar Ribonucleoprotein, Homolog (Yeast) 2
  • IMP4, U3 Small Nucleolar Ribonucleoprotein, Homolog 3
  • U3 SnoRNP Protein 4 Homolog 3

External Ids for IMP4 Gene

Previous GeneCards Identifiers for IMP4 Gene

  • GC02P131004
  • GC02P131193
  • GC02P130816
  • GC02P131099
  • GC02P123390

Summaries for IMP4 Gene

Entrez Gene Summary for IMP4 Gene

  • The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for IMP4 Gene

IMP4 (IMP4 Homolog, U3 Small Nucleolar Ribonucleoprotein) is a Protein Coding gene. Among its related pathways are Gene Expression and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include snoRNA binding and rRNA primary transcript binding.

UniProtKB/Swiss-Prot for IMP4 Gene

  • Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Gene Wiki entry for IMP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMP4 Gene

Genomics for IMP4 Gene

Regulatory Elements for IMP4 Gene

Promoters for IMP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IMP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for IMP4 Gene

Chromosome:
2
Start:
130,342,225 bp from pter
End:
130,347,810 bp from pter
Size:
5,586 bases
Orientation:
Plus strand

Genomic View for IMP4 Gene

Genes around IMP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IMP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IMP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMP4 Gene

Proteins for IMP4 Gene

  • Protein details for IMP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G21-IMP4_HUMAN
    Recommended name:
    U3 small nucleolar ribonucleoprotein protein IMP4
    Protein Accession:
    Q96G21
    Secondary Accessions:
    • Q3ZTT3

    Protein attributes for IMP4 Gene

    Size:
    291 amino acids
    Molecular mass:
    33757 Da
    Quaternary structure:
    • Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.

neXtProt entry for IMP4 Gene

Proteomics data for IMP4 Gene at MOPED

Post-translational modifications for IMP4 Gene

  • Ubiquitination at Lys 183
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for IMP4 Gene

Domains & Families for IMP4 Gene

Protein Domains for IMP4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IMP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G21

UniProtKB/Swiss-Prot:

IMP4_HUMAN :
  • Contains 1 Brix domain.
Domain:
  • Contains 1 Brix domain.
genes like me logo Genes that share domains with IMP4: view

No data available for Gene Families for IMP4 Gene

Function for IMP4 Gene

Molecular function for IMP4 Gene

UniProtKB/Swiss-Prot Function:
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Gene Ontology (GO) - Molecular Function for IMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042134 rRNA primary transcript binding IBA --
genes like me logo Genes that share ontologies with IMP4: view
genes like me logo Genes that share phenotypes with IMP4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IMP4 Gene

Localization for IMP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IMP4 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IMP4 Gene COMPARTMENTS Subcellular localization image for IMP4 gene
Compartment Confidence
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 12655004
genes like me logo Genes that share ontologies with IMP4: view

Pathways & Interactions for IMP4 Gene

genes like me logo Genes that share pathways with IMP4: view

Pathways by source for IMP4 Gene

Gene Ontology (GO) - Biological Process for IMP4 Gene

None

No data available for SIGNOR curated interactions for IMP4 Gene

Drugs & Compounds for IMP4 Gene

No Compound Related Data Available

Transcripts for IMP4 Gene

Unigene Clusters for IMP4 Gene

IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IMP4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: - - - - -
SP9: - - -
SP10:
SP11:
SP12:

Relevant External Links for IMP4 Gene

GeneLoc Exon Structure for
IMP4
ECgene alternative splicing isoforms for
IMP4

Expression for IMP4 Gene

mRNA expression in normal human tissues for IMP4 Gene

Protein differential expression in normal tissues from HIPED for IMP4 Gene

This gene is overexpressed in Plasma (26.6), Cervix (21.6), and Lung (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IMP4 Gene



SOURCE GeneReport for Unigene cluster for IMP4 Gene Hs.91579

genes like me logo Genes that share expression patterns with IMP4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IMP4 Gene

Orthologs for IMP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IMP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IMP4 35
  • 87.74 (n)
  • 95.71 (a)
IMP4 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IMP4 35
  • 87.64 (n)
  • 94.91 (a)
IMP4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Imp4 35
  • 87.62 (n)
  • 97.86 (a)
Imp4 16
Imp4 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IMP4 35
  • 98.74 (n)
  • 98.28 (a)
IMP4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Imp4 35
  • 86.31 (n)
  • 97.86 (a)
oppossum
(Monodelphis domestica)
Mammalia IMP4 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IMP4 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves IMP4 35
  • 63.9 (n)
  • 63.9 (a)
IMP4 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IMP4 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia imp4 35
  • 74.17 (n)
  • 78.57 (a)
Str.1165 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6114 35
zebrafish
(Danio rerio)
Actinopterygii Dr.19345 35
imp4 35
  • 67.38 (n)
  • 76.43 (a)
imp4 36
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2996 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003890 35
  • 58.9 (n)
  • 60.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11920 35
  • 56.2 (n)
  • 53.79 (a)
CG11920 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_ZK795.3 35
  • 56 (n)
  • 60.66 (a)
ZK795.3 36
  • 59 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER430W 35
  • 55.43 (n)
  • 51.48 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E07833g 35
  • 49.51 (n)
  • 51.85 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IMP4 35
  • 49.15 (n)
  • 52.19 (a)
IMP4 36
  • 52 (a)
OneToOne
IMP4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons IMP4 35
  • 53.38 (n)
  • 51.09 (a)
rice
(Oryza sativa)
Liliopsida Os08g0155000 35
  • 56.7 (n)
  • 57.69 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8068 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04243 35
  • 51.59 (n)
  • 46.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC19A8.07c 35
  • 50.69 (n)
  • 51.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6162 36
  • 63 (a)
OneToOne
Species with no ortholog for IMP4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IMP4 Gene

ENSEMBL:
Gene Tree for IMP4 (if available)
TreeFam:
Gene Tree for IMP4 (if available)

Paralogs for IMP4 Gene

(1) SIMAP similar genes for IMP4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IMP4: view

No data available for Paralogs for IMP4 Gene

Variants for IMP4 Gene

Sequence variations from dbSNP and Humsavar for IMP4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2292850 -- 130,344,965(-) GTCTT(G/T)CCCCA intron-variant
rs2292851 -- 130,344,829(-) GACAA(A/G)GGCAT intron-variant
rs11542413 -- 130,345,790(+) TCATC(A/G)TCAGC reference, missense
rs11542414 -- 130,346,476(+) ACACT(C/T)ACCAC utr-variant-3-prime
rs11542415 -- 130,346,062(+) GATGA(C/G/T)AGCCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IMP4 Gene

Variant ID Type Subtype PubMed ID
nsv459274 CNV Loss 19166990
dgv1247e1 CNV Complex 17122850
esv2751826 CNV Gain 17911159
dgv1250e1 CNV Complex 17122850
nsv428403 CNV Loss 18775914
dgv4305n71 CNV Gain 21882294
dgv4306n71 CNV Gain 21882294
nsv7327 OTHER Inversion 18451855
dgv4307n71 CNV Gain 21882294
nsv520559 CNV Gain+Loss 19592680
nsv875084 CNV Gain+Loss 21882294
dgv4308n71 CNV Gain 21882294
nsv470485 CNV Gain 18288195
nsv818080 CNV Gain 17921354
dgv475n27 CNV Gain 19166990
essv2399 CNV CNV 17122850
dgv4309n71 CNV Gain 21882294
nsv459341 CNV Loss 19166990
nsv875097 CNV Loss 21882294
nsv875098 CNV Gain 21882294
dgv4310n71 CNV Gain 21882294

Variation tolerance for IMP4 Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.55; 72.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IMP4 Gene

HapMap Linkage Disequilibrium report
IMP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IMP4 Gene

Disorders for IMP4 Gene

Relevant External Links for IMP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IMP4

No disorders were found for IMP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IMP4 Gene

Publications for IMP4 Gene

  1. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. (PMID: 12655004) Granneman S. … Pruijn G.J.M. (Nucleic Acids Res. 2003) 2 3 4 67
  2. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for IMP4 Gene

Sources for IMP4 Gene

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