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IMP4 Gene

protein-coding   GIFtS: 54
GCID: GC02P131099

IMP4, U3 Small Nucleolar Ribonucleoprotein

(Previous names: IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast))
  Search for IMP4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IMP4, U3 Small Nucleolar Ribonucleoprotein1 2     IMP4, U3 Small Nucleolar Ribonucleoprotein, Homolog (Yeast)1
BXDC42 3 5     IMP4, U3 Small Nucleolar Ribonucleoprotein, Homolog2
Brix Domain-Containing Protein 42 3     U3 Small Nucleolar Ribonucleoprotein Protein IMP42
U3 SnoRNP Protein IMP42 3     U3 SnoRNP Protein 4 Homolog2

External Ids:    HGNC: 308561   Entrez Gene: 928562   Ensembl: ENSG000001367187   OMIM: 6129815   UniProtKB: Q96G213   

Export aliases for IMP4 gene to outside databases

Previous GC identifers: GC02P131004 GC02P131193 GC02P130816 GC02P123390


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IMP4 Gene:
IMP4 forms a ternary complex with IMP3 (MIM 612980) and MPP10 (MPHOSPHO10; MIM 605503) that interacts with U3
small nucleolar RNA (snoRNA), which is required for the early cleavage steps in pre-rRNA processing (Granneman et
al., 2003 (PubMed 12655004)).(supplied by OMIM, Aug 2009)

GeneCards Summary for IMP4 Gene:
IMP4 (IMP4, U3 small nucleolar ribonucleoprotein) is a protein-coding gene.

UniProtKB/Swiss-Prot: IMP4_HUMAN, Q96G21
Function: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early
cleavages during pre-18S ribosomal RNA processing

Gene Wiki entry for IMP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IMP4 gene promoter:
         SRF   SRF (504 AA)   MyoD   MIF-1   YY1   CREB   PPAR-alpha   deltaCREB   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIMP4 promoter sequence
   Search Chromatin IP Primers for IMP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IMP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21.1

IMP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IMP4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P131099:  view genomic region     (about GC identifiers)

Start:
131,099,798 bp from pter      End:
131,105,383 bp from pter
Size:
5,586 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IMP4_HUMAN, Q96G21 (See protein sequence)
Recommended Name: U3 small nucleolar ribonucleoprotein protein IMP4  
Size: 291 amino acids; 33757 Da
Subunit: Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10
Secondary accessions: Q3ZTT3

Explore the universe of human proteins at neXtProt for IMP4: NX_Q96G21

Explore proteomics data for IMP4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys183
  • Modification sites at PhosphoSitePlus

  • See IMP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_219484.1  
    ENSEMBL proteins: 
     ENSP00000259239   ENSP00000386411   ENSP00000386716   ENSP00000416756   ENSP00000389701  
     ENSP00000409371  

    IMP4 Human Recombinant Protein Products:

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    Novus Biologicals IMP4 Protein
    Novus Biologicals IMP4 Lysate
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    Cloud-Clone Corp. Proteins for IMP4

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007109 Brix
     IPR004154 Anticodon-bd

    Graphical View of Domain Structure for InterPro Entry Q96G21

    ProtoNet protein and cluster: Q96G21

    1 Blocks protein domain: IPB007109 Brix domain

    UniProtKB/Swiss-Prot: IMP4_HUMAN, Q96G21
    Similarity: Contains 1 Brix domain


    Find genes that share domains with IMP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IMP4_HUMAN, Q96G21
    Function: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early
    cleavages during pre-18S ribosomal RNA processing

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12655004
         
    Find genes that share ontologies with IMP4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for IMP4:
     Nuclear 40S maturation defects  Nucleolar pre-40S maturation d 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IMP4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IMP4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IMP4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IMP4

    miRNA
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    miRTarBase miRNAs that target IMP4:
    hsa-mir-320a (MIRT044455), hsa-mir-98-5p (MIRT027762)

    Block miRNA regulation of human, mouse, rat IMP4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IMP4
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    Predesigned siRNA for gene silencing in human, mouse, rat IMP4

    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for IMP4
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IMP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IMP4_HUMAN, Q96G21: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA12655004
    GO:0030529ribonucleoprotein complex IEA--

    Find genes that share ontologies with IMP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IMP4 About    
    See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes


    Find genes that share SuperPaths with IMP4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for IMP4):
        Ribosome biogenesis in eukaryotes

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IMP4
    Interactions:

        GeneGlobe Interaction Network for IMP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IMP4 (Q96G213 ENSP000002592394) via UniProtKB, MINT, STRING, and/or I2D (see all 235)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing NAS12655004

    Find genes that share ontologies with IMP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IMP4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IMP4 gene: 
    NM_033416.1  

    Unigene Cluster for IMP4:

    IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
    Hs.91579  [show with all ESTs]
    Unigene Representative Sequence: AF054996
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259239(uc002tra.1) ENST00000409935 ENST00000490895 ENST00000464432
    ENST00000462392 ENST00000473689 ENST00000470672 ENST00000477375 ENST00000409649
    ENST00000456713 ENST00000495606 ENST00000460766 ENST00000428740 ENST00000452955
    ENST00000460100 ENST00000462357 ENST00000475074
    miRNA
    Products:
         
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IMP4
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    OriGene ORF clones in mouse, rat for IMP4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IMP4 (NM_003256)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IMP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMP4
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IMP4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IMP4
      QuantiTect SYBR Green Assays in human, mouse, rat IMP4
      QuantiFast Probe-based Assays in human, mouse, rat IMP4

    Additional mRNA sequence: 

    AF054996.1 AK289878.1 AK292345.1 AK312808.1 AY364245.1 BC010042.1 

    Selected DOTS entries (see all 29):

    DT.450053  DT.91948915  DT.100883138  DT.120981334  DT.92445665  DT.75121503  DT.100883130  DT.120980760 
    DT.100766528  DT.100038658  DT.120981118  DT.100883144  DT.120981417  DT.91639139  DT.100883137  DT.100664930 
    DT.100883131  DT.100883153  DT.92410799  DT.97860327  DT.100761357  DT.120980911  DT.120981316  DT.120981345 

    Selected AceView cDNA sequences (see all 377):

    BM479134 BM794988 BM747882 AA988456 AF054996 BQ689899 BQ574839 BM927168 
    BQ889555 AA809328 CD365640 CB156743 AA767301 CF552770 BF525851 BI761694 
    BG253898 NM_033416 BM787472 H21404 N62833 BG677213 BG747960 AI188061 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IMP4 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
    SP1:                                      -     -     -           -           -                                         -               
    SP2:                    -                 -     -     -           -           -                                         -               
    SP3:                                            -     -           -           -                                                         
    SP4:                    -                 -     -     -                       -                                                         
    SP5:                                      -     -     -                       -                                                         


    ECgene alternative splicing isoforms for IMP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IMP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IMP4 Expression
    About this image

    IMP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IMP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.91579
        Custom PCR Arrays for IMP4
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IMP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IMP4 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Imp41 , 5 IMP4, U3 small nucleolar ribonucleoprotein, homolog more1, 5 87.62(n)1
    97.86(a)1
      1 (13.22 cM)5
    279931  NM_178601.31  NP_848716.21 
     344398515 
    chicken
    (Gallus gallus)
    Aves IMP41 IMP4, U3 small nucleolar ribonucleoprotein, homolog more 63.9(n)
    63.9(a)
      100857200  NM_001277715.1  NP_001264644.1 
    lizard
    (Anolis carolinensis)
    Reptilia IMP46
    IMP4, U3 small nucleolar ribonucleoprotein, homolo...
    85(a)
    1 ↔ 1
    2(68997140-69012888)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.61142 Xenopus laevis transcribed sequence with weak similarity more 77.22(n)    BU901638.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.193452 Transcribed sequence with weak similarity to protein more 76.06(n)    BQ450453.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG119201 CG11920 56.2(n)
    53.79(a)
      43009  NM_143078.2  NP_651335.2 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_ZK795.31 CELE_ZK795.3 56(n)
    60.66(a)
      178207  NM_070003.4  NP_502404.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IMP4(YNL075W)4
    IMP41
    Component of the SSU processome, which is required more4
    IMP41
    49.15(n)1
    52.19(a)1
      14(485607-486479)4
    8556491, 4  NP_014324.31  NP_014324.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons IMP41 IMP4 53.38(n)
    51.09(a)
      842682  NM_105054.3  NP_176564.1 
    rice
    (Oryza sativa)
    Liliopsida AK099613.12   -- 73.29(n)    AK099613.1 


    ENSEMBL Gene Tree for IMP4 (if available)
    TreeFam Gene Tree for IMP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IMP4 gene
    1 SIMAP similar gene for IMP4 using alignment to 6 protein entries:     IMP4_HUMAN (see all proteins):
    RPF1

    Find genes that share paralogs with IMP4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IMP4 (see all 134)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs791641541,2
    C--131102067(+) TATCCA/GTGCTT 1 -- int10--------
    rs1811364011,2
    --131102105(+) TTTTTA/GTTTCA 1 -- int10--------
    rs1419153451,2
    --131102120(+) TGTGCA/GGGCTA 1 -- int10--------
    rs2011817211,2
    C--131102182(+) CAGCCC/TCTCTC 1 -- int10--------
    rs348157851,2
    C,F--131102232(+) ACGCCG/AAGAGG 2 /Q /R mis14Minor allele frequency- A:0.00NA CSA 4634
    rs1506023451,2
    C,F--131102263(+) CTGGAG/ATTTGA 2 /E syn11Minor allele frequency- A:0.00NA 4552
    rs1387255731,2
    C--131102272(+) GATGAG/TGCTGG 2 E D mis10--------
    rs22928511,2
    F--131102402(-) GACAAG/AGGCAT 1 -- int11Minor allele frequency- A:0.01EA 1498
    rs1125557261,2
    F--131102494(+) TCTGCG/ACCTGG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs22928501,2
    C,F,A,H--131102538(-) GTCTTG/TCCCCA 1 -- int126Minor allele frequency- N:0.00EA NS NA WA CSA 4005

    HapMap Linkage Disequilibrium report for IMP4 (131099798 - 131105383 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IMP4 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv459274CNV Loss19166990
    nsv428403CNV Loss18775914
    nsv875097CNV Loss21882294
    nsv459341CNV Loss19166990
    dgv4306n71CNV Gain21882294
    dgv4309n71CNV Gain21882294
    dgv475n27CNV Gain19166990
    nsv818080CNV Gain17921354
    dgv4305n71CNV Gain21882294
    dgv4308n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612981    OMIM disorders: --


    Find genes that share disorders with IMP4           About GenesLikeMe


    Export disorders for IMP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IMP4 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with IMP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. (PubMed id 12655004)1, 2, 3 Granneman S.... Pruijn G.J.M. (Nucleic Acids Res. 2003)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
    5. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. NovelFam3000 -- uncharacterized human protein domains conserved across model organisms. (PubMed id 16533400)2 Kemmer D.... Wasserman W.W. (BMC Genomics 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92856 HGNC: 30856 AceView: IMP4 Ensembl:ENSG00000136718 euGenes: HUgn92856
    ECgene: IMP4 Kegg: 92856 H-InvDB: IMP4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IMP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IMP4 gene:
    Search GeneIP for patents involving IMP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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