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Aliases for IMP4 Gene

Aliases for IMP4 Gene

  • IMP4, U3 Small Nucleolar Ribonucleoprotein 2 3 5
  • Brix Domain-Containing Protein 4 3 4
  • U3 SnoRNP Protein IMP4 3 4
  • BXDC4 3 4
  • IMP4, U3 Small Nucleolar Ribonucleoprotein, Homolog (Yeast) 2
  • IMP4, U3 Small Nucleolar Ribonucleoprotein, Homolog 3
  • IMP4 Homolog, U3 Small Nucleolar Ribonucleoprotein 3
  • U3 Small Nucleolar Ribonucleoprotein Protein IMP4 3
  • U3 SnoRNP Protein 4 Homolog 3

External Ids for IMP4 Gene

Previous GeneCards Identifiers for IMP4 Gene

  • GC02P131004
  • GC02P131193
  • GC02P130816
  • GC02P131099
  • GC02P123390

Summaries for IMP4 Gene

Entrez Gene Summary for IMP4 Gene

  • The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for IMP4 Gene

IMP4 (IMP4, U3 Small Nucleolar Ribonucleoprotein) is a Protein Coding gene. Among its related pathways are MAPK-Erk Pathway and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include snoRNA binding and rRNA primary transcript binding.

UniProtKB/Swiss-Prot for IMP4 Gene

  • Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Gene Wiki entry for IMP4 Gene

Additional gene information for IMP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMP4 Gene

Genomics for IMP4 Gene

Regulatory Elements for IMP4 Gene

Enhancers for IMP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H131016 0.8 Ensembl ENCODE 4.2 +675.4 675420 2.3 ZFHX2 NFIB GLIS1 CEBPB ZNF398 PRDM1 EGR2 MZT2A IMP4 PIR58035 GC02P130994
GH02H130327 0.4 ENCODE 5 -13.6 -13594 1.8 CTCF NRF1 PTPN18 KLF2P1 TUBA3E IMP4 ENSG00000224352 TEKT4P3
GH02H130336 1.4 Ensembl ENCODE 0.7 -3.9 -3918 3.5 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZNF766 ZNF143 ZNF207 FOS SMPD4 PTPN18 RAB6C-AS1 IMP4 TRE-TTC1-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IMP4 on UCSC Golden Path with GeneCards custom track

Promoters for IMP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for IMP4 Gene

Genomic Locations for IMP4 Gene
5,586 bases
Plus strand

Genomic View for IMP4 Gene

Genes around IMP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IMP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IMP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMP4 Gene

Proteins for IMP4 Gene

  • Protein details for IMP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U3 small nucleolar ribonucleoprotein protein IMP4
    Protein Accession:
    Secondary Accessions:
    • Q3ZTT3

    Protein attributes for IMP4 Gene

    291 amino acids
    Molecular mass:
    33757 Da
    Quaternary structure:
    • Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.

neXtProt entry for IMP4 Gene

Post-translational modifications for IMP4 Gene

  • Ubiquitination at posLast=183183
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IMP4 Gene

Domains & Families for IMP4 Gene

Gene Families for IMP4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for IMP4 Gene


Suggested Antigen Peptide Sequences for IMP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IMP4: view

No data available for UniProtKB/Swiss-Prot for IMP4 Gene

Function for IMP4 Gene

Molecular function for IMP4 Gene

UniProtKB/Swiss-Prot Function:
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Gene Ontology (GO) - Molecular Function for IMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12655004
GO:0030515 snoRNA binding IBA --
GO:0042134 rRNA primary transcript binding IBA --
genes like me logo Genes that share ontologies with IMP4: view
genes like me logo Genes that share phenotypes with IMP4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IMP4 Gene

Localization for IMP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IMP4 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IMP4 gene
Compartment Confidence
nucleus 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 12655004
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with IMP4: view

Pathways & Interactions for IMP4 Gene

genes like me logo Genes that share pathways with IMP4: view

Gene Ontology (GO) - Biological Process for IMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing NAS,TAS --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with IMP4: view

No data available for SIGNOR curated interactions for IMP4 Gene

Drugs & Compounds for IMP4 Gene

No Compound Related Data Available

Transcripts for IMP4 Gene

Unigene Clusters for IMP4 Gene

IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IMP4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: - - - - -
SP9: - - -

Relevant External Links for IMP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IMP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IMP4 Gene

Protein differential expression in normal tissues from HIPED for IMP4 Gene

This gene is overexpressed in Plasma (26.6), Cervix (21.6), and Lung (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IMP4 Gene

NURSA nuclear receptor signaling pathways regulating expression of IMP4 Gene:


SOURCE GeneReport for Unigene cluster for IMP4 Gene:


Evidence on tissue expression from TISSUES for IMP4 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with IMP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IMP4 Gene

Orthologs for IMP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IMP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IMP4 33 34
  • 98.74 (n)
(Bos Taurus)
Mammalia IMP4 33 34
  • 87.74 (n)
(Canis familiaris)
Mammalia IMP4 33 34
  • 87.64 (n)
(Mus musculus)
Mammalia Imp4 33 16 34
  • 87.62 (n)
(Rattus norvegicus)
Mammalia Imp4 33
  • 86.31 (n)
(Monodelphis domestica)
Mammalia IMP4 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia IMP4 34
  • 80 (a)
(Gallus gallus)
Aves IMP4 33 34
  • 63.9 (n)
(Anolis carolinensis)
Reptilia IMP4 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia imp4 33
  • 74.17 (n)
Str.1165 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6114 33
(Danio rerio)
Actinopterygii imp4 33 34
  • 67.38 (n)
Dr.19345 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2996 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003890 33
  • 58.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11920 33 34
  • 56.2 (n)
(Caenorhabditis elegans)
Secernentea ZK795.3 34
  • 59 (a)
CELE_ZK795.3 33
  • 56 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER430W 33
  • 55.43 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E07833g 33
  • 49.51 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IMP4 33 34 36
  • 49.15 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons IMP4 33
  • 53.38 (n)
(Oryza sativa)
Liliopsida Os08g0155000 33
  • 56.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6162 34
  • 63 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04243 33
  • 51.59 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC19A8.07c 33
  • 50.69 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8068 33
Species where no ortholog for IMP4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IMP4 Gene

Gene Tree for IMP4 (if available)
Gene Tree for IMP4 (if available)

Paralogs for IMP4 Gene

(1) SIMAP similar genes for IMP4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IMP4: view

No data available for Paralogs for IMP4 Gene

Variants for IMP4 Gene

Sequence variations from dbSNP and Humsavar for IMP4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs751325113 Pathogenic 130,342,034(+) CGTTC(A/G)ACACC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs869025583 Pathogenic 130,342,095(-) AGCTG(G/T)ATTCG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000095126 -- 130,341,416(+) ACACA(C/T)AGATA intron-variant, upstream-variant-2KB
rs1000327396 -- 130,344,162(+) TCTCT(A/T)CTAAA intron-variant, upstream-variant-2KB
rs1000490505 -- 130,342,695(+) AAGTC(A/G)CGTGT upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for IMP4 Gene

Variant ID Type Subtype PubMed ID
nsv998333 CNV gain+loss 25217958
nsv818080 CNV gain 17921354
nsv7327 OTHER inversion 18451855
nsv583133 CNV loss 21841781
nsv583132 CNV gain 21841781
nsv583113 CNV gain 21841781
nsv583046 CNV loss 21841781
nsv520559 CNV gain+loss 19592680
nsv470485 CNV gain 18288195
nsv459341 CNV loss 19166990
nsv459274 CNV loss 19166990
nsv428403 CNV loss 18775914
nsv1147463 OTHER inversion 26484159
nsv1005664 CNV loss 25217958
nsv1001073 CNV gain 25217958
esv3893326 CNV gain 25118596
esv3592451 CNV gain 21293372
esv3592450 CNV loss 21293372
esv3584065 CNV loss 25503493
esv2763387 CNV loss 21179565
esv2760631 CNV gain+loss 21179565
esv2759092 CNV gain+loss 17122850
esv2751826 CNV gain 17911159
dgv7083n54 CNV loss 21841781
dgv7080n54 CNV gain 21841781
dgv7079n54 CNV loss 21841781
dgv475n27 CNV gain 19166990
dgv4073n100 CNV gain 25217958
dgv2032n106 OTHER inversion 24896259

Variation tolerance for IMP4 Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.55; 72.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IMP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IMP4 Gene

Disorders for IMP4 Gene

Relevant External Links for IMP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IMP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IMP4 Gene

Publications for IMP4 Gene

  1. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. (PMID: 12655004) Granneman S … Pruijn GJ (Nucleic acids research 2003) 2 3 4 60
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 60
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 60

Products for IMP4 Gene

Sources for IMP4 Gene

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