IMP3 Gene
protein-coding GIFtS: 52
GCID: GC15M075931
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IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)(Previous names: mitochondrial ribosomal protein S4, chromosome 15 open...)
(Previous symbols: MRPS4, C15orf12)
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Aliases
for IMP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| IMP3, U3 Small Nucleolar Ribonucleoprotein, Homolog (Yeast)1 2 | | FLJ109681 | | BRMS21 2 3 5 | | Chromosome 15 Open Reading Frame 121 | | MRPS41 2 3 5 | | Mitochondrial Ribosomal Protein S41 | | C15orf121 2 3 | | U3 Small Nucleolar Ribonucleoprotein Protein IMP32 | | U3 SnoRNP Protein IMP32 3 | | U3 SnoRNP Protein 3 Homolog2 |
Export aliases for IMP3 gene to outside databasesPrevious GC identifers: GC15M073719 GC15M052687 |
Summaries
for IMP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IMP3:
This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts withthe U3 snoRNP complex. The protein contains an S4 domain. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: IMP3_HUMAN, Q9NV31Function: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavagesduring pre-18S ribosomal RNA processing
Gene Wiki entry for IMP3
|
Genomic Views
for IMP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IMP3 gene promoter:
SRF p53 SRF (504 AA) FOXO3 FOXO3a STAT5A Tal-1beta FOXO3b En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IMP3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IMP3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q24 Ensembl cytogenetic band: 15q24.2 HGNC cytogenetic band: 15q24IMP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M075931: view genomic region
(about GC identifiers)
Start:
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75,931,426 bp from pter |
End:
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75,941,047 bp from pter |
Size:
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9,622 bases |
Orientation:
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minus strand |
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Proteins
for IMP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IMP3_HUMAN, Q9NV31 (See
protein sequence)Recommended Name: U3 small nucleolar ribonucleoprotein protein IMP3 Size: 184 amino acids; 21850 Da
Subunit: Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10
Subcellular location: Nucleus, nucleolus
1 PDB 3D structure from  and Proteopedia  for IMP3:2CQJ (3D)
Secondary accessions: B3KQ67 Q53G10Explore the universe of human proteins at neXtProt for IMP3: NX_Q9NV31
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NV31
IMP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060755.1
ENSEMBL proteins: ENSP00000326981 ENSP00000385217
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
IMP3 for ontologies About GeneDecksing
IMP3 Antibody Products:
Assay Products for IMP3: |
Protein
Domains /
Families
for IMP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IMP3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NV31ProtoNet protein and cluster: Q9NV31 2 Blocks protein families: IPB001912 Ribosomal protein S4 IPB002942 RNA-binding S4
UniProtKB/Swiss-Prot: IMP3_HUMAN, Q9NV31Similarity: Belongs to the ribosomal protein S4P familySimilarity: Contains 1 S4 RNA-binding domain |
Function
for IMP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IMP3_HUMAN, Q9NV31Function: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavagesduring pre-18S ribosomal RNA processing
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IMP3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IMP3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IMP3 (NM_000362) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IMP3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMP3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IMP3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
IMP3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for IMP3:
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Pathways & Interactions
for IMP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ribosome biogenesis in eukaryotes | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for IMP3):
IMP3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IMP3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/98 Interacting proteins for IMP3 (Q9NV312, 3 ENSP000003269814) via UniProtKB, MINT, STRING, and/or I2D (see all 98)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006364 | rRNA processing |
IEA | -- |
IMP3 for ontologies About GeneDecksing
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Drugs & Compounds
for IMP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IMP3
Search CenterWatch for drugs/clinical trials and news about IMP3
|
Transcripts
for IMP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IMP3 gene: NM_018285.3 Unigene Cluster for IMP3: IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast) Hs.513043 [show with all ESTs]Unigene Representative Sequence: BM5420903 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000314852(uc002bat.2) ENST00000565349 ENST00000403490
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IMP3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IMP3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IMP3 (NM_000362) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IMP3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMP3 |
Additional cDNA sequence: AK001830.1 AK223121.1 AK307159.1 AL136913.1 AY050497.1 BC006487.1 BC011745.2 BC020557.2 11 DOTS entries: DT.92440652 DT.448090 DT.100806827 DT.95159750 DT.100812850 DT.100819507 DT.100819504 DT.121052586 DT.95159760 DT.97820062 DT.100723474 24/387 AceView cDNA sequences (see all 387): AA639860 AA614467 CB109638 BM796680 BQ049205 W73226 AI597896 CB109878 BI225648 BM474156 R10729 CB109927 BE542990 BM704861 BG027395 BG503800 BU506814 CB145339 CB109346 AY050497 AA805485 CR599893 BU149088 BQ880266
GeneLoc Exon Structure
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Expression
for IMP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IMP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATAGAGCCA
About this image
See IMP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IMP3
SOURCE GeneReport for Unigene cluster: Hs.513043
SABiosciences Custom PCR Arrays for IMP3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IMP3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IMP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IMP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IMP3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IMP3 |
Orthologs
for IMP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for IMP3 gene from 10/37 species (see all 37) About this table
ENSEMBL Gene Tree for IMP3 (if available)
TreeFam Gene Tree for IMP3 (if available) |
Paralogs
for IMP3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IMP3 gene
IMP3 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for IMP3
PGOHUM00000233563 PGOHUM00000235962
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Genomic Variants
for IMP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IMP3 (75931426 - 75941047 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IMP3: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for IMP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IMP3 for disorders About GeneDecksing
OMIM gene information: 612980
OMIM disorders: --
19  diseases for IMP3: About MalaCardsbile duct carcinoma adenoid cystic carcinoma pancreatic ductal adenocarcinoma malignant mesothelioma
intrahepatic cholangiocarcinoma adenoiditis cholangiocarcinoma colon cancer
ovarian cancer osteosarcoma adenocarcinoma prostate cancer
pancreatitis carcinoma esophagitis neuroblastoma
prostatitis thyroiditis malaria
Export disorders for IMP3 gene to outside databases
|
Publications
for IMP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IMP3 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with IMP3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. (PubMed id 12655004)1, 2, 3, 9 Granneman S....Pruijn G.J. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 3 Kenmochi N....Tanaka T. (2001)
- Regulation of IMP3 by EGFR signaling and repression by ERb: implications for triple-negative breast cancer. (PubMed id 22266872)1 Samanta S....Mercurio A.M. (2012)
- IMP3 immunocytochemical staining increases sensitivity in the routine cytologic evaluation of biliary brush specimens. (PubMed id 22431320)1 Hart J....Ligato S. (2012)
- Functional invadopodia formation through stabilization of the PDPN transcript by IMP-3 and cancer-stromal crosstalk for PDPN expressio n. (PubMed id 22859271)1 Hwang Y.S....Chung W.Y. (2012)
- Oncofetal protein, IMP-3, a potential marker for predi ction of postoperative peritoneal dissemination in gastric adenocarcinoma. (PubMed id 22012575)1 Okada K....Doki Y. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
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External Searches for IMP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing IMP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IMP3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IMP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IMP3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for IMP3 gene:
Search GeneIP for patents involving IMP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IMP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IMP3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IMP3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IMP3 | | | OriGene Protein Over-expression Lysate for IMP3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IMP3 | | OriGene 3'-UTR Clone for IMP3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IMP3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IMP3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IMP3 | | OriGene Custom Protein Services for IMP3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IMP3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IMP3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IMP3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IMP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IMP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IMP3 |
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| | | | Search Tocris compounds for IMP3 |
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 | | | IMP3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IMP3 |
|  |  |  | | | | ThermoFisher Antibody for IMP3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMP3 |
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