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Aliases for IMP3 Gene

Aliases for IMP3 Gene

  • IMP3, U3 Small Nucleolar Ribonucleoprotein 2 3 5
  • U3 SnoRNP Protein IMP3 3 4
  • C15orf12 3 4
  • MRPS4 3 4
  • BRMS2 3 4
  • IMP3, U3 Small Nucleolar Ribonucleoprotein, Homolog (Yeast) 2
  • IMP3, U3 Small Nucleolar Ribonucleoprotein, Homolog 3
  • Chromosome 15 Open Reading Frame 12 2
  • Mitochondrial Ribosomal Protein S4 2
  • U3 SnoRNP Protein 3 Homolog 3

External Ids for IMP3 Gene

Previous HGNC Symbols for IMP3 Gene

  • MRPS4
  • C15orf12

Previous GeneCards Identifiers for IMP3 Gene

  • GC15M073719
  • GC15M075931
  • GC15M052687

Summaries for IMP3 Gene

Entrez Gene Summary for IMP3 Gene

  • This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for IMP3 Gene

IMP3 (IMP3, U3 Small Nucleolar Ribonucleoprotein) is a Protein Coding gene. Diseases associated with IMP3 include pilomyxoid astrocytoma. Among its related pathways are Gene Expression and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for IMP3 Gene

  • Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Gene Wiki entry for IMP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMP3 Gene

Genomics for IMP3 Gene

Regulatory Elements for IMP3 Gene

Promoters for IMP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IMP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for IMP3 Gene

Chromosome:
15
Start:
75,639,085 bp from pter
End:
75,648,706 bp from pter
Size:
9,622 bases
Orientation:
Minus strand

Genomic View for IMP3 Gene

Genes around IMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMP3 Gene

Proteins for IMP3 Gene

  • Protein details for IMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV31-IMP3_HUMAN
    Recommended name:
    U3 small nucleolar ribonucleoprotein protein IMP3
    Protein Accession:
    Q9NV31
    Secondary Accessions:
    • B3KQ67
    • Q53G10

    Protein attributes for IMP3 Gene

    Size:
    184 amino acids
    Molecular mass:
    21850 Da
    Quaternary structure:
    • Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.

    Three dimensional structures from OCA and Proteopedia for IMP3 Gene

neXtProt entry for IMP3 Gene

Proteomics data for IMP3 Gene at MOPED

Post-translational modifications for IMP3 Gene

  • Ubiquitination at Lys 82
  • Modification sites at PhosphoSitePlus

Other Protein References for IMP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IMP3 Gene

Domains & Families for IMP3 Gene

Protein Domains for IMP3 Gene

Suggested Antigen Peptide Sequences for IMP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NV31

UniProtKB/Swiss-Prot:

IMP3_HUMAN :
  • Contains 1 S4 RNA-binding domain.
  • Belongs to the ribosomal protein S4P family.
Domain:
  • Contains 1 S4 RNA-binding domain.
Family:
  • Belongs to the ribosomal protein S4P family.
genes like me logo Genes that share domains with IMP3: view

No data available for Gene Families for IMP3 Gene

Function for IMP3 Gene

Molecular function for IMP3 Gene

UniProtKB/Swiss-Prot Function:
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Gene Ontology (GO) - Molecular Function for IMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with IMP3: view
genes like me logo Genes that share phenotypes with IMP3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IMP3 Gene

Localization for IMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IMP3 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IMP3 Gene COMPARTMENTS Subcellular localization image for IMP3 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015935 NOT small ribosomal subunit IBA --
genes like me logo Genes that share ontologies with IMP3: view

Pathways & Interactions for IMP3 Gene

genes like me logo Genes that share pathways with IMP3: view

Pathways by source for IMP3 Gene

Gene Ontology (GO) - Biological Process for IMP3 Gene

None

No data available for SIGNOR curated interactions for IMP3 Gene

Drugs & Compounds for IMP3 Gene

No Compound Related Data Available

Transcripts for IMP3 Gene

mRNA/cDNA for IMP3 Gene

Unigene Clusters for IMP3 Gene

IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IMP3 Gene

No ASD Table

Relevant External Links for IMP3 Gene

GeneLoc Exon Structure for
IMP3
ECgene alternative splicing isoforms for
IMP3

Expression for IMP3 Gene

mRNA expression in normal human tissues for IMP3 Gene

Protein differential expression in normal tissues from HIPED for IMP3 Gene

This gene is overexpressed in Monocytes (16.8), Tlymphocyte (12.9), Peripheral blood mononuclear cells (7.0), and Bone (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IMP3 Gene



SOURCE GeneReport for Unigene cluster for IMP3 Gene Hs.513043

genes like me logo Genes that share expression patterns with IMP3: view

Protein tissue co-expression partners for IMP3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IMP3 Gene

Orthologs for IMP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IMP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IMP3 35
  • 90.4 (n)
  • 97.83 (a)
IMP3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IMP3 35
  • 91.67 (n)
  • 96.2 (a)
IMP3 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Imp3 35
  • 89.86 (n)
  • 96.2 (a)
Imp3 16
Imp3 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IMP3 35
  • 99.64 (n)
  • 100 (a)
IMP3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Imp3 35
  • 88.59 (n)
  • 96.2 (a)
oppossum
(Monodelphis domestica)
Mammalia IMP3 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IMP3 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia imp3 35
  • 64.83 (n)
  • 71.82 (a)
Str.17594 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.10835 35
zebrafish
(Danio rerio)
Actinopterygii imp3 35
  • 60.98 (n)
  • 67.06 (a)
zgc56526 35
imp3 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006372 35
  • 62.25 (n)
  • 57.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4866 35
  • 58.38 (n)
  • 57.46 (a)
CG4866 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C48B6.2 35
  • 52.49 (n)
  • 51.38 (a)
C48B6.2 36
  • 51 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL131C 35
  • 61.3 (n)
  • 54.44 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15995g 35
  • 52.78 (n)
  • 54.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IMP3 35
  • 52.67 (n)
  • 54.14 (a)
IMP3 36
  • 54 (a)
OneToOne
IMP3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15750 35
  • 54.03 (n)
  • 53.3 (a)
soybean
(Glycine max)
eudicotyledons Gma.3731 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5075 35
rice
(Oryza sativa)
Liliopsida Os.15267 35
Os04g0662100 35
  • 62.96 (n)
  • 69.14 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.13412 35
corn
(Zea mays)
Liliopsida Zm.3908 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01008 35
  • 56.35 (n)
  • 50.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes imp3 35
  • 51.38 (n)
  • 49.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.54 36
  • 63 (a)
OneToOne
Species with no ortholog for IMP3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for IMP3 Gene

ENSEMBL:
Gene Tree for IMP3 (if available)
TreeFam:
Gene Tree for IMP3 (if available)

Paralogs for IMP3 Gene

Pseudogenes.org Pseudogenes for IMP3 Gene

genes like me logo Genes that share paralogs with IMP3: view

No data available for Paralogs for IMP3 Gene

Variants for IMP3 Gene

Sequence variations from dbSNP and Humsavar for IMP3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs13737 -- 75,639,788(-) GCTGC(A/C/T)GTGGC reference, synonymous-codon
rs1139203 -- 75,640,675(+) TCCCC(C/G)CCGCC upstream-variant-2KB
rs3203297 -- 75,640,747(+) GTGGC(A/C)CCGAA upstream-variant-2KB
rs4886724 -- 75,639,436(+) ACATT(C/T)CCTGG utr-variant-3-prime
rs7168301 -- 75,641,302(+) tgcgc(A/G)cctgt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IMP3 Gene

Variant ID Type Subtype PubMed ID
esv2749894 CNV Deletion 23290073
esv2749895 CNV Deletion 23290073
nsv527186 CNV Loss 19592680
dgv2415n71 CNV Loss 21882294
dgv2416n71 CNV Loss 21882294

Variation tolerance for IMP3 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IMP3 Gene

HapMap Linkage Disequilibrium report
IMP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IMP3 Gene

Disorders for IMP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IMP3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
pilomyxoid astrocytoma
- elite association - COSMIC cancer census association via MalaCards
Search IMP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IMP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IMP3
genes like me logo Genes that share disorders with IMP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IMP3 Gene

Publications for IMP3 Gene

  1. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. (PMID: 12655004) Granneman S. … Pruijn G.J.M. (Nucleic Acids Res. 2003) 2 3 4 23 67
  2. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3
  3. IMP-3 promotes migration and invasion of melanoma cells by modulating the expression of HMGA2 and predicts poor prognosis in melanoma. (PMID: 25380351) Sheen Y.S. … Chu C.Y. (J. Invest. Dermatol. 2015) 3
  4. Expression of IMP3 and IGF2 in giant cell tumor of spine is associated with tumor recurrence and angiogenesis. (PMID: 25740666) Zhang K. … Yang H. (Clin Transl Oncol 2015) 3
  5. Overexpression of the RNA-binding proteins Lin28B and IGF2BP3 (IMP3) is associated with chemoresistance and poor disease outcome in ovarian cancer. (PMID: 26158423) Hsu K.F. … Ho C.L. (Br. J. Cancer 2015) 3

Products for IMP3 Gene

Sources for IMP3 Gene

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