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IMP3 Gene

protein-coding   GIFtS: 54
GCID: GC15M075931

IMP3, U3 Small Nucleolar Ribonucleoprotein

(Previous names: mitochondrial ribosomal protein S4, chromosome 15 open reading...)
(Previous symbols: MRPS4, C15orf12)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IMP3, U3 Small Nucleolar Ribonucleoprotein1 2     IMP3, U3 Small Nucleolar Ribonucleoprotein, Homolog (Yeast)1
MRPS41 2 3 5     Mitochondrial Ribosomal Protein S41
C15orf121 2 3     IMP3, U3 Small Nucleolar Ribonucleoprotein, Homolog2
BRMS22 3 5     U3 Small Nucleolar Ribonucleoprotein Protein IMP32
U3 SnoRNP Protein IMP32 3     U3 SnoRNP Protein 3 Homolog2
Chromosome 15 Open Reading Frame 121     

External Ids:    HGNC: 144971   Entrez Gene: 552722   Ensembl: ENSG000001779717   OMIM: 6129805   UniProtKB: Q9NV313   

Export aliases for IMP3 gene to outside databases

Previous GC identifers: GC15M073719 GC15M052687


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IMP3 Gene:
This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts
with the U3 snoRNP complex. The protein contains an S4 domain. (provided by RefSeq, Jul 2008)

GeneCards Summary for IMP3 Gene:
IMP3 (IMP3, U3 small nucleolar ribonucleoprotein) is a protein-coding gene. Diseases associated with IMP3 include gastric adenocarcinoma, and bile duct carcinoma. GO annotations related to this gene include rRNA binding.

UniProtKB/Swiss-Prot: IMP3_HUMAN, Q9NV31
Function: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early
cleavages during pre-18S ribosomal RNA processing

Gene Wiki entry for IMP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the IMP3 gene promoter:
         SRF   p53   SRF (504 AA)   FOXO3   FOXO3a   STAT5A   Tal-1beta   FOXO3b   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIMP3 promoter sequence
   Search Chromatin IP Primers for IMP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IMP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q24

IMP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IMP3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M075931:  view genomic region     (about GC identifiers)

Start:
75,931,426 bp from pter      End:
75,941,047 bp from pter
Size:
9,622 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IMP3_HUMAN, Q9NV31 (See protein sequence)
Recommended Name: U3 small nucleolar ribonucleoprotein protein IMP3  
Size: 184 amino acids; 21850 Da
Subunit: Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10
1 PDB 3D structure from and Proteopedia for IMP3:
2CQJ (3D)    
Secondary accessions: B3KQ67 Q53G10

Explore the universe of human proteins at neXtProt for IMP3: NX_Q9NV31

Explore proteomics data for IMP3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys82
  • Modification sites at PhosphoSitePlus

  • See IMP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060755.1  
    ENSEMBL proteins: 
     ENSP00000326981   ENSP00000385217  

    IMP3 Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for IMP3
    Browse Proteins at Cloud-Clone Corp.

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    IMP3 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR022801 Ribosomal_S4/S9
     IPR002942 S4_RNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9NV31

    ProtoNet protein and cluster: Q9NV31

    2 Blocks protein domains:
    IPB001912 Ribosomal protein S4
    IPB002942 RNA-binding S4


    UniProtKB/Swiss-Prot: IMP3_HUMAN, Q9NV31
    Similarity: Belongs to the ribosomal protein S4P family
    Similarity: Contains 1 S4 RNA-binding domain


    IMP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IMP3_HUMAN, Q9NV31
    Function: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early
    cleavages during pre-18S ribosomal RNA processing

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI12655004
    GO:0019843rRNA binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    IMP3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IMP3:
     Nucleolar pre-40S maturation d 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IMP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IMP3

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IMP3

    miRNA
    Products:
        
    miRTarBase miRNAs that target IMP3:
    hsa-mir-26b-5p (MIRT028891), hsa-mir-34a-5p (MIRT025305)

    Block miRNA regulation of human, mouse, rat IMP3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IMP3
    SwitchGear 3'UTR luciferase reporter plasmidIMP3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IMP3

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMP3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IMP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IMP3_HUMAN, Q9NV31: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA12655004
    GO:0030529ribonucleoprotein complex IEA--

    IMP3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IMP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for IMP3):
        Ribosome biogenesis in eukaryotes


    IMP3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IMP3
    Interactions:

        Search GeneGlobe Interaction Network for IMP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IMP3 (Q9NV312, 3 ENSP000003269814) via UniProtKB, MINT, STRING, and/or I2D (see all 315)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--

    IMP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IMP3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IMP3 gene: 
    NM_018285.3  

    Unigene Cluster for IMP3:

    IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
    Hs.513043  [show with all ESTs]
    Unigene Representative Sequence: BM542090
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314852(uc002bat.2) ENST00000565349 ENST00000403490
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IMP3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IMP3
    SwitchGear 3'UTR luciferase reporter plasmidIMP3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IMP3
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    OriGene ORF clones in mouse, rat for IMP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IMP3 (NM_000362)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IMP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMP3
    Primer
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    OriGene qPCR primer pairs and template standards for IMP3
    OriGene qSTAR qPCR primer pairs in human, mouse for IMP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IMP3
      QuantiTect SYBR Green Assays in human, mouse, rat IMP3
      QuantiFast Probe-based Assays in human, mouse, rat IMP3

    Additional mRNA sequence: 

    AK001830.1 AK223121.1 AK307159.1 AL136913.1 AY050497.1 BC006487.1 BC011745.2 BC020557.2 

    11 DOTS entries:

    DT.92440652  DT.448090  DT.100806827  DT.95159750  DT.100812850  DT.100819507  DT.100819504  DT.121052586 
    DT.95159760  DT.97820062  DT.100723474 

    Selected AceView cDNA sequences (see all 387):

    R10729 BC011745 Z39312 CR590019 AA252370 AL110462 BU506814 BI834678 
    CB109426 CR604682 AA973646 BP430676 AA805485 CB109346 BU177159 BI754594 
    AA970149 BE748142 T74821 BG503800 BM796680 AA865089 F04823 BM474156 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IMP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATAGAGCCA
    IMP3 Expression
    About this image

    IMP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IMP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513043
        Custom PCR Arrays for IMP3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IMP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IMP3 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Imp31 , 5 IMP3, U3 small nucleolar ribonucleoprotein, homolog more1, 5 89.86(n)1
    96.2(a)1
      9 (30.53 cM)5
    1024621  NM_133976.21  NP_598737.11 
     569374755 
    lizard
    (Anolis carolinensis)
    Reptilia IMP36
    IMP3, U3 small nucleolar ribonucleoprotein, homolo...
    73(a)
    1 ↔ 1
    GL343325.1(239270-239833)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.108352 Xenopus laevis transcribed sequence with moderate similarity more 75.91(n)    CA983055.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565262 hypothetical protein MGC56526 73.01(n)   393237  BC049039.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG48661 CG4866 58.38(n)
    57.46(a)
      36976  NM_137380.3  NP_611224.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C48B6.21 C48B6.2 52.49(n)
    51.38(a)
      172420  NM_059571.5  NP_491972.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IMP3(YHR148W)4
    IMP31
    Component of the SSU processome, which is required more4
    IMP31
    52.67(n)1
    54.14(a)1
      8(393534-394085)4
    8565531, 4  NP_012018.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G157501 AT5G15750 54.03(n)
    53.3(a)
      831431  NM_121580.2  NP_568321.1 
    rice
    (Oryza sativa)
    Liliopsida Os.152672 Oryza sativa (japonica cultivar-group) cDNA clone0 more 76.28(n)    AK109706.1 


    ENSEMBL Gene Tree for IMP3 (if available)
    TreeFam Gene Tree for IMP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IMP3 gene

    IMP3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for IMP3
    PGOHUM00000233563 PGOHUM00000235962


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IMP3 (see all 92)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1835753651,2
    --75930997(+) AACATC/TCTGCA 1 -- ds50010--------
    rs1896139281,2
    --75931042(+) ACAGGA/CAGGTC 1 -- ds50010--------
    rs99204471,2
    C,F,H--75931123(+) AggctG/Aggcgc 1 -- ds50019Minor allele frequency- A:0.02NS EA NA 1094
    rs1930918251,2
    --75931185(+) TCACGA/TGTTCA 1 -- ds50010--------
    rs1432529171,2
    --75931278(+) GCCTAC/TACTCC 1 -- ds50010--------
    rs1856917451,2
    --75931333(+) AGGCGA/GAGGTT 1 -- ds50010--------
    rs1898189561,2
    --75931472(+) CATTTA/CAACAA 1 -- ut310--------
    rs1388258831,2
    --75931628(+) GAAACA/TGGGCG 1 -- ut310--------
    rs757738721,2
    C,F--75931735(+) CAAGGC/TACAGT 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs48867241,2
    C,H--75931777(+) ACATTT/CCCTGG 1 -- ut3113Minor allele frequency- C:0.01NA WA CSA EA 378

    HapMap Linkage Disequilibrium report for IMP3 (75931426 - 75941047 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for IMP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749894CNV Deletion23290073
    esv2749895CNV Deletion23290073
    dgv2416n71CNV Loss21882294
    dgv2415n71CNV Loss21882294
    nsv527186CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IMP3
    DNA2.0 Custom Variant and Variant Library Synthesis for IMP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612980    OMIM disorders: --

    Selected diseases for IMP3 (see all 30):    
    About MalaCards
    gastric adenocarcinoma    bile duct carcinoma    adenoid cystic carcinoma    pancreatic ductal adenocarcinoma
    keratoacanthoma    adenoiditis    leiomyosarcoma    malignant mesothelioma
    pancreatic endocrine tumors    lung squamous cell carcinoma    cervical intraepithelial neoplasia    intrahepatic cholangiocarcinoma
    small cell carcinoma    peritonitis    cholangiocarcinoma    adenocarcinoma
    osteosarcoma    neuroblastoma    esophagitis    lung adenocarcinoma


    IMP3 for disorders           About GeneDecksing


    Export disorders for IMP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IMP3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with IMP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. (PubMed id 12655004)1, 2, 3, 9 Granneman S.... Pruijn G.J.M. (Nucleic Acids Res. 2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 3 Kenmochi N.... Tanaka T. (Genomics 2001)
    6. Combined detection of p16(INK4a) and IMP3 increase the concordance rate between cervical cytologic and histologic diagnosis. (PubMed id 23923073)1 Wei Q....Zhao T. (Int J Clin Exp Pathol 2013)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55272 HGNC: 14497 AceView: C15orf12 Ensembl:ENSG00000177971 euGenes: HUgn55272
    ECgene: IMP3 Kegg: 55272 H-InvDB: IMP3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IMP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IMP3 gene:
    Search GeneIP for patents involving IMP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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