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IMP3 Gene

protein-coding   GIFtS: 54

GC15M073719
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
(Previous names: mitochondrial ribosomal protein S4, chromosome 15 open reading frame 12 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: MRPS4, C15orf12)
Services    

Aliases &
Descriptions
for IMP3

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
BRMS2 1, 2, 3
C15orf12 2, 3
DKFZp586L0118 2
FLJ10968 1, 2
MRPS4 2, 3
SPPL2A 5
Descriptions
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast) 2
U3 snoRNP protein 3 homolog 2
U3 snoRNP protein IMP3 3
chromosome 15 open reading frame 12 1
mitochondrial ribosomal protein S4 1
External Ids
HGNC: 144971
Entrez Gene: 552722
UniProtKB: Q9NV313
Ensembl: ENSG000001779717
Search outside databases for aliases for IMP3 gene

Summaries
for IMP3

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for IMP3:
This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the
nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by
RefSeq]

UniProtKB/Swiss-Prot: IMP3_HUMAN, Q9NV31
Function: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for
the early cleavages during pre-18S ribosomal RNA processing

Gene Wiki entry for IMP3

Genomic Location
for IMP3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the IMP3 gene  

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q24

IMP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M073719:     (about GC identifiers)

Start:
 73,718,481 bp from pter
End:
 73,728,102 bp from pter
Size:
 9,622 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000015.8  NT_010194.16  

Proteins
for IMP3

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: IMP3_HUMAN, Q9NV31 (See protein sequence)
Recommended Name: U3 small nucleolar ribonucleoprotein protein IMP3  
Size: 184 amino acids; 21850 Da
Subunit: Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with
MPHOSPH10
Subcellular location: Nucleus, nucleolus
PDB structures from and Proteopedia :
2CQJ (3D)    
Secondary accessions: Q53G10

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_060755.1  

    ENSEMBL proteins: 
    ENSP00000385217 ENSP00000326981 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (IMP3)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    GO:0005730 nucleolus IDA12655004
    GO:0030529 ribonucleoprotein complex IEA--
    About this table

    Antibodies for IMP3: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for IMP3

    Assays for IMP3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for IMP3

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR002942 S4_RNA_bd
     IPR001912 Ribosomal_S4
     IPR018079 Ribosomal_S4_CS


       GeneDecks  IMP3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9NV31

    ProtoNet protein and cluster: Q9NV31

    2 Blocks protein families:
    IPB001912 Ribosomal protein S4
    IPB002942 RNA-binding S4


    UniProtKB/Swiss-Prot: IMP3_HUMAN, Q9NV31
    Similarity: Belongs to the ribosomal protein S4P family
    Similarity: Contains 1 S4 RNA-binding domain

    Gene Function
    for IMP3

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (IMP3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (IMP3)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018285

                  Applied Biosystems Silencer® siRNAs for IMP3

                  Sigma-Aldrich siRNA for IMP3  
                         Sigma-Aldrich shRNA for IMP3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for IMP3
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018285
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018285
                                     untagged cDNA clone in CMV expression vector: NM_018285 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_018285

    UniProtKB/Swiss-Prot: IMP3_HUMAN, Q9NV31
    Function: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for
    the early cleavages during pre-18S ribosomal RNA processing

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI12655004
    GO:0019843 rRNA binding IEA--
    About this table

    Pathways & Interactions
    for IMP3

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5/7 Interacting proteins for IMP3 (Q9NV312 ENSP000003269813) via UniProtKB, MINT, and/or STRING (see all 7 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LPXNO607112MINT-67065
    PNO1ENSP000002636573STRING (score=.75)
    MPHOSPH10ENSP000002442303STRING (score=.749)
    EMG1ENSP000002614063STRING (score=.738)
    KRR1ENSP000002292143STRING (score=.725)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364 rRNA processing IEA--
    About this table

    Drugs & Compounds
    for IMP3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for IMP3

    Transcripts
    for IMP3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (IMP3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (IMP3)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018285

                  Sigma-Aldrich siRNA for IMP3  
                         Sigma-Aldrich shRNA for IMP3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_018285  

    REFSEQ mRNAs for IMP3 gene: 

    NM_018285.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_018285  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018285
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018285
                                     untagged cDNA clone in CMV expression vector: NM_018285 

    Additional cDNA sequence: 

    AK001830.1 AK223121.1 AK307159.1 AL136913.1 AY050497.1 BC006487.1 BC011745.2 BC020557.2 
    CR590019.1 CR599893.1 CR601431.1 CR604682.1 

    10 DOTS entries:

    DT.92440652  DT.448090  DT.100806827  DT.95159750  DT.100812850  DT.100819507  DT.100819504  DT.97820062 
    DT.100723474  DT.121052586 

    24/387 AceView cDNA sequences (see all 387 ):

    BM474156 BI838066 BU789349 W73226 CB109445 AA865089 AA805485 BI225648 
    BG236839 AY050497 AA973646 CB109346 BM453521 BM762076 AA252370 CB145339 
    AA639860 BG281195 BM450180 BQ880266 BG503800 AI675795 BE542990 BI754594 

    highest scoring ESTs for IMP3:

    AA313706 AA336528 AA403275 AI870481 AK001830 AL110462 AU134944 AW248337 AW955929 AY050497 

    Unigene Cluster for IMP3:

    IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
    Hs.513043  [show with all ESTs]
    Unigene Representative Sequence: BM542090


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000403490  ENST00000314852  

    Expression
    for IMP3

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    IMP3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for IMP3

    1 / 2 / 3

    3 probe-sets matching IMP3 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		57201_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI870481 0.80 1.00 0.91 1

    		221688_s_at2, 3 U133-A 1 1.00 1.00 -- -- AL136913 0.60 1.00 0.82 1

    		221688_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CATAGAGCCA

    SOURCE GeneReport for Unigene cluster: Hs.513043

    Orthologs
    for IMP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for IMP3 gene from 5/24 species (see all 24 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 IMP31   -- IMP3, U3 small nucleolar ribonucleoprotein, homolog more 91.67(n)
    96.2(a)    		 487656  XM_544781.2  XP_544781.1 
    chimpanzee
    (Pan troglodytes)    		 IMP31   -- IMP3, U3 small nucleolar ribonucleoprotein, homolog more 99.64(n)
    100(a)    		 453760  XM_510683.2  XP_510683.2 
    cow
    (Bos taurus)    		 IMP31   -- IMP3, U3 small nucleolar ribonucleoprotein, homolog more 90.58(n)
    98.37(a)    		 511560  XM_001251855.1  XP_001251856.1 
    rat
    (Rattus norvegicus)    		 Imp31   -- IMP3, U3 small nucleolar ribonucleoprotein, homolog more 88.59(n)
    96.2(a)    		 315697  XM_236276.4  XP_236276.4 
    mouse
    (Mus musculus)    		 Imp31, 5 95
    		 IMP3, U3 small nucleolar ribonucleoprotein, homolog more1, 5 89.86(n)1
    96.2(a)1    		 1024621  NM_133976.21  NP_598737.11 
     AI2565945  AK0044565  (see all 9)
    About this table        Species with no ortholog for IMP3

    ENSEMBL Gene Tree for IMP3

    Paralogs
    for IMP3

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for IMP3 gene
    RPS9P42  

    SNPs/Variants
    for IMP3

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/27 NCBI SNPs in IMP3 are shown (see all 27 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 15)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    --
    rs71683011,2
    		A,C73720698(+) tgcgcA/Gcctgt 1 -- ng310--------
    rs110725531,2
    		A,C73719832(+) GGTTCC/TGCGCG 1 -- ng310--------
    rs32032971,2
    		F73720143(+) GTGGCA/CCCGAA 1 -- ng311Minor allele frequency- C:0.02MN 184
    rs48867241,2
    		C73718832(+) ACATTC/TCCTGG 1 -- ut310--------
    --
    rs99204471,2
    		H73718178(+) AggctG/Aggcgc 1 -- ng514Minor allele frequency- A:0.00EU EA WA 416
    rs137371,2
    		C,F,H73719184(-) GCTGCC/AGTGGC 1 A/A syn16Minor allele frequency- A:0.33MN EU EA WA 782
    --
    rs558164761,2
    		--73720847(+) ATATA-/TAAAATA 1 -- ng310--------
    --
    rs727328511,2
    		--73720947(+) TAGGCA/CTGGTG 1 -- ng310--------
    --
    rs124375861,2
    		--73720632(+) AAAAAA/GAAAAA 1 -- ng31 trp30--------
    --
    rs607372331,2
    		--73720724(+) GGAGGA/CTGAGG 1 -- ng310--------
    About this table

    HapMap Linkage Disequilibrium images for IMP3 (up to first 250kb)

    Disorders & Mutations
    for IMP3

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 608238

    Medical News
    for IMP3

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    Publications
    for IMP3

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/19 PubMed articles for IMP3 gene (see all 19 ):

    Search for IMP3

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IMP3

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 55272 HGNC: 14497 AceView: C15orf12 Ensembl:ENSG00000177971 euGenes: HUgn55272
    ECgene: IMP3 H-InvDB: IMP3

    Other Databases showing IMP3

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing IMP3

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for IMP3

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for IMP3

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for IMP3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for IMP3-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for IMP3 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for IMP3 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

     Recombinant Proteins (IMP3)
     Search for Antibodies
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     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Search for Recombinant Proteins
     Search for Antibodies
     Search OriGene for IMP3
     Search Tocris compounds for IMP3




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for IMP3

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