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Aliases for IMP3 Gene

Aliases for IMP3 Gene

  • IMP3, U3 Small Nucleolar Ribonucleoprotein 2 3
  • MRPS4 3 4 6
  • BRMS2 3 4 6
  • U3 SnoRNP Protein IMP3 3 4
  • C15orf12 3 4
  • IMP3, U3 Small Nucleolar Ribonucleoprotein, Homolog (Yeast) 2
  • IMP3, U3 Small Nucleolar Ribonucleoprotein, Homolog 3
  • U3 Small Nucleolar Ribonucleoprotein Protein IMP3 3
  • Chromosome 15 Open Reading Frame 12 2
  • Mitochondrial Ribosomal Protein S4 2
  • U3 SnoRNP Protein 3 Homolog 3

External Ids for IMP3 Gene

Previous Symbols for IMP3 Gene

  • MRPS4
  • C15orf12

Summaries for IMP3 Gene

Entrez Gene Summary for IMP3 Gene

  • This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for IMP3 Gene

IMP3 (IMP3, U3 Small Nucleolar Ribonucleoprotein) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include rRNA binding.

UniProtKB/Swiss-Prot for IMP3 Gene

  • Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Gene Wiki entry for IMP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMP3 Gene

Genomics for IMP3 Gene

Genomic Location for IMP3 Gene

75,639,085 bp from pter
75,648,706 bp from pter
9,622 bases
Minus strand

Genomic View for IMP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMP3 Gene

Regulatory Elements for IMP3 Gene

Proteins for IMP3 Gene

  • Protein details for IMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U3 small nucleolar ribonucleoprotein protein IMP3
    Protein Accession:
    Secondary Accessions:
    • B3KQ67
    • Q53G10

    Protein attributes for IMP3 Gene

    184 amino acids
    Molecular mass:
    21850 Da
    Quaternary structure:
    • Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.

    Three dimensional structures from OCA and Proteopedia for IMP3 Gene

neXtProt entry for IMP3 Gene

Proteomics data for IMP3 Gene at MOPED

Post-translational modifications for IMP3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys82

Other Protein References for IMP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IMP3 Gene

Domains for IMP3 Gene

Protein Domains for IMP3 Gene

Suggested Antigen Peptide Sequences for IMP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 S4 RNA-binding domain.:
    • Q9NV31
  • Belongs to the ribosomal protein S4P family.:
    • Q9NV31
genes like me logo Genes that share domains with IMP3: view

No data available for Gene Families for IMP3 Gene

Function for IMP3 Gene

Molecular function for IMP3 Gene

UniProtKB/Swiss-Prot Function: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Gene Ontology (GO) - Molecular Function for IMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0003735 NOT structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 12655004
GO:0019843 NOT rRNA binding IBA --
GO:0030515 snoRNA binding IBA --
genes like me logo Genes that share ontologies with IMP3: view

Phenotypes for IMP3 Gene

GenomeRNAi human phenotypes for IMP3:
genes like me logo Genes that share phenotypes with IMP3: view

miRNA for IMP3 Gene

miRTarBase miRNAs that target IMP3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IMP3 Gene

Localization for IMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IMP3 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for IMP3 Gene COMPARTMENTS Subcellular localization image for IMP3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0015935 NOT small ribosomal subunit IBA --
GO:0030529 ribonucleoprotein complex --
genes like me logo Genes that share ontologies with IMP3: view

Pathways for IMP3 Gene

genes like me logo Genes that share pathways with IMP3: view

Pathways by source for IMP3 Gene

1 KEGG pathway for IMP3 Gene

Gene Ontology (GO) - Biological Process for IMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IBA --
GO:0045903 NOT positive regulation of translational fidelity IBA --
genes like me logo Genes that share ontologies with IMP3: view

Transcripts for IMP3 Gene

mRNA/cDNA for IMP3 Gene

Unigene Clusters for IMP3 Gene

IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IMP3 Gene

No ASD Table

Relevant External Links for IMP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IMP3 Gene

mRNA expression in normal human tissues for IMP3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for IMP3 Gene

SOURCE GeneReport for Unigene cluster for IMP3 Gene Hs.513043

genes like me logo Genes that share expressions with IMP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IMP3 Gene

Orthologs for IMP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IMP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IMP3 35
  • 99.64 (n)
  • 100 (a)
IMP3 36
  • 100 (a)
(Bos Taurus)
Mammalia IMP3 35
  • 90.4 (n)
  • 97.83 (a)
IMP3 36
  • 98 (a)
(Canis familiaris)
Mammalia IMP3 35
  • 91.67 (n)
  • 96.2 (a)
IMP3 36
  • 79 (a)
(Mus musculus)
Mammalia Imp3 35
  • 89.86 (n)
  • 96.2 (a)
Imp3 16
Imp3 36
  • 96 (a)
(Monodelphis domestica)
Mammalia IMP3 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Imp3 35
  • 88.59 (n)
  • 96.2 (a)
(Anolis carolinensis)
Reptilia IMP3 36
  • 73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10835 35
tropical clawed frog
(Silurana tropicalis)
Amphibia imp3 35
  • 64.83 (n)
  • 71.82 (a)
Str.17594 35
(Danio rerio)
Actinopterygii imp3 35
  • 60.98 (n)
  • 67.06 (a)
imp3 36
  • 69 (a)
zgc56526 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006372 35
  • 62.25 (n)
  • 57.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4866 35
  • 58.38 (n)
  • 57.46 (a)
CG4866 36
  • 57 (a)
(Caenorhabditis elegans)
Secernentea C48B6.2 35
  • 52.49 (n)
  • 51.38 (a)
C48B6.2 36
  • 51 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL131C 35
  • 61.3 (n)
  • 54.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IMP3 35
  • 52.67 (n)
  • 54.14 (a)
IMP3 36
  • 54 (a)
IMP3 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15995g 35
  • 52.78 (n)
  • 54.44 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5075 35
(Glycine max)
eudicotyledons Gma.3731 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15750 35
  • 54.03 (n)
  • 53.3 (a)
(Zea mays)
Liliopsida Zm.3908 35
(Oryza sativa)
Liliopsida Os.15267 35
Os04g0662100 35
  • 62.96 (n)
  • 69.14 (a)
(Triticum aestivum)
Liliopsida Ta.13412 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01008 35
  • 56.35 (n)
  • 50.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes imp3 35
  • 51.38 (n)
  • 49.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.54 36
  • 63 (a)
Species with no ortholog for IMP3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for IMP3 Gene

Gene Tree for IMP3 (if available)
Gene Tree for IMP3 (if available)

Paralogs for IMP3 Gene Pseudogenes for IMP3 Gene

genes like me logo Genes that share paralogs with IMP3: view

No data available for Paralogs for IMP3 Gene

Variants for IMP3 Gene

Sequence variations from dbSNP and Humsavar for IMP3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs13737 -- 75,639,788(-) GCTGC(A/C)GTGGC synonymous-codon, reference
rs1139203 -- 75,640,675(+) TCCCC(C/G)CCGCC upstream-variant-2KB
rs3203297 -- 75,640,747(+) GTGGC(A/C)CCGAA upstream-variant-2KB
rs4886724 -- 75,639,436(+) ACATT(C/T)CCTGG utr-variant-3-prime
rs7168301 -- 75,641,302(+) tgcgc(A/G)cctgt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IMP3 Gene

Variant ID Type Subtype PubMed ID
esv2749894 CNV Deletion 23290073
esv2749895 CNV Deletion 23290073
nsv527186 CNV Loss 19592680
dgv2415n71 CNV Loss 21882294
dgv2416n71 CNV Loss 21882294

Relevant External Links for IMP3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IMP3 Gene

Disorders for IMP3 Gene

No disorders were found for IMP3 Gene.

No data available for UniProtKB/Swiss-Prot for IMP3 Gene

Publications for IMP3 Gene

  1. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. (PMID: 12655004) Granneman S. … Pruijn G.J.M. (Nucleic Acids Res. 2003) 2 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for IMP3 Gene

Sources for IMP3 Gene

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