Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IMMT Gene

Aliases for IMMT Gene

  • Inner Membrane Protein, Mitochondrial 2 3
  • Mitofilin 2 3 4
  • HMP 3 4 6
  • Mitochondrial Inner Membrane Organizing System 2 2 3
  • Cell Proliferation-Inducing Gene 4/52 Protein 3 4
  • Mitochondrial Inner Membrane Protein 3 4
  • P87/89 3 4
  • MINOS2 3 4
  • Inner Membrane Protein, Mitochondrial (Mitofilin) 2
  • Cell Proliferation-Inducing Protein 52 3
  • Proliferation-Inducing Gene 4 3
  • MICOS Complex Subunit MIC60 3
  • Motor Protein 3
  • PIG52 3
  • MIC60 4
  • PIG4 3
  • P87 3
  • P89 3

External Ids for IMMT Gene

Summaries for IMMT Gene

GeneCards Summary for IMMT Gene

IMMT (Inner Membrane Protein, Mitochondrial) is a Protein Coding gene. Diseases associated with IMMT include melanoma-associated retinopathy and gracile syndrome.

UniProtKB/Swiss-Prot for IMMT Gene

  • Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

Gene Wiki entry for IMMT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMMT Gene

Genomics for IMMT Gene

Genomic Location for IMMT Gene

Start:
86,143,932 bp from pter
End:
86,195,770 bp from pter
Size:
51,839 bases
Orientation:
Minus strand

Genomic View for IMMT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IMMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMMT Gene

Regulatory Elements for IMMT Gene

Proteins for IMMT Gene

  • Protein details for IMMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16891-MIC60_HUMAN
    Recommended name:
    MICOS complex subunit MIC60
    Protein Accession:
    Q16891
    Secondary Accessions:
    • B1H0U5
    • B2R5N6
    • Q14539
    • Q15092
    • Q68D41
    • Q69HW5
    • Q6IBL0
    • Q7Z3X1
    • Q8TAJ5
    • Q9P0V2

    Protein attributes for IMMT Gene

    Size:
    758 amino acids
    Molecular mass:
    83678 Da
    Quaternary structure:
    • Interacts with HSPA1A/HSPA1B and OPA1, preferentially with the soluble OPA1 form (By similarity). Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27 and IMMT/MIC60. The complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2, and with HSPA9.
    SequenceCaution:
    • Sequence=CAH18389.1; Type=Erroneous termination; Positions=759; Note=Translated as stop.; Evidence={ECO:0000305};

    Alternative splice isoforms for IMMT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IMMT Gene

Proteomics data for IMMT Gene at MOPED

Post-translational modifications for IMMT Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys102, Lys110, and Lys451

No data available for DME Specific Peptides for IMMT Gene

Domains for IMMT Gene

Protein Domains for IMMT Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MIC60_HUMAN
Family:
  • Belongs to the MICOS complex subunit Mic60 family.:
    • Q16891
genes like me logo Genes that share domains with IMMT: view

No data available for Gene Families for IMMT Gene

Function for IMMT Gene

Molecular function for IMMT Gene

UniProtKB/Swiss-Prot Function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

Gene Ontology (GO) - Molecular Function for IMMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with IMMT: view

miRNA for IMMT Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IMMT Gene

Localization for IMMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for IMMT Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IMMT Gene COMPARTMENTS Subcellular localization image for IMMT gene
Compartment Confidence
mitochondrion 5
nucleus 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IMMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IDA 9168817
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IMMT: view

Pathways for IMMT Gene

SuperPathways for IMMT Gene

No Data Available

Gene Ontology (GO) - Biological Process for IMMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0009409 response to cold IEA --
GO:0051560 mitochondrial calcium ion homeostasis IEA --
genes like me logo Genes that share ontologies with IMMT: view

No data available for Pathways by source for IMMT Gene

Compounds for IMMT Gene

(6) Novoseek inferred chemical compound relationships for IMMT Gene

Compound -log(P) Hits PubMed IDs
atp 37.9 4
oxygen 12.6 2
adp 0.0887 1
nitric oxide 0 9
lipid 0 1
genes like me logo Genes that share compounds with IMMT: view

Transcripts for IMMT Gene

Unigene Clusters for IMMT Gene

Inner membrane protein, mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IMMT Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - - - - - - - - - -
SP12: - - -
SP13:
SP14: - - - - - - - - - -
SP15: - - -

ExUns: 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for IMMT Gene

GeneLoc Exon Structure for
IMMT
ECgene alternative splicing isoforms for
IMMT

Expression for IMMT Gene

mRNA expression in normal human tissues for IMMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IMMT Gene

This gene is overexpressed in Heart - Left Ventricle (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IMMT Gene

SOURCE GeneReport for Unigene cluster for IMMT Gene Hs.148559

genes like me logo Genes that share expressions with IMMT: view

Orthologs for IMMT Gene

This gene was present in the common ancestor of animals.

Orthologs for IMMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IMMT 36
  • 99.91 (n)
  • 100 (a)
IMMT 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IMMT 36
  • 88.38 (n)
  • 89.86 (a)
IMMT 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IMMT 36
  • 91.78 (n)
  • 92.61 (a)
IMMT 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Immt 36
  • 88.15 (n)
  • 90.09 (a)
Immt 16
Immt 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IMMT 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IMMT 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Immt 36
  • 86.37 (n)
  • 86.37 (a)
chicken
(Gallus gallus)
Aves IMMT 36
  • 73.94 (n)
  • 77.46 (a)
IMMT 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IMMT 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8878 36
tropical clawed frog
(Silurana tropicalis)
Amphibia immt 36
  • 66.22 (n)
  • 67.47 (a)
Str.11537 36
zebrafish
(Danio rerio)
Actinopterygii immt 36
  • 62.67 (n)
  • 62.13 (a)
immt 37
  • 59 (a)
OneToOne
wufd16e04 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002364 36
  • 43.22 (n)
  • 30.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6455 36
  • 45.13 (n)
  • 33.6 (a)
CG6455 37
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea immt-1 36
  • 45.17 (n)
  • 33.28 (a)
immt-1 37
  • 29 (a)
OneToMany
immt-2 37
  • 26 (a)
OneToMany
T14G11.3 38
  • 27 (a)
W06H3.1 38
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5015 37
  • 35 (a)
OneToOne
Species with no ortholog for IMMT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IMMT Gene

ENSEMBL:
Gene Tree for IMMT (if available)
TreeFam:
Gene Tree for IMMT (if available)

Paralogs for IMMT Gene

Pseudogenes.org Pseudogenes for IMMT Gene

genes like me logo Genes that share paralogs with IMMT: view

No data available for Paralogs for IMMT Gene

Variants for IMMT Gene

Sequence variations from dbSNP and Humsavar for IMMT Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs11845 -- 86,144,110(-) TTTCC(A/T)TTTGC utr-variant-3-prime
rs965636 -- 86,186,327(-) tggaT(A/G)TTATC intron-variant
rs1050301 -- 86,173,701(-) AACAG(C/G/T)CTGCC reference, missense
rs1057893 -- 86,158,545(-) CCACT(A/G)ATCAA intron-variant
rs1124685 -- 86,148,966(+) CTTGC(C/T)CTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IMMT Gene

Variant ID Type Subtype PubMed ID
esv2751903 CNV Gain 17911159
nsv458563 CNV Gain 19166990
esv2720300 CNV Deletion 23290073
nsv458574 CNV Gain 19166990

Relevant External Links for IMMT Gene

HapMap Linkage Disequilibrium report
IMMT
Human Gene Mutation Database (HGMD)
IMMT

Disorders for IMMT Gene

(3) Novoseek inferred disease relationships for IMMT Gene

Disease -log(P) Hits PubMed IDs
lymphoma b-cell 33 1
biliary cirrhosis primary 23.6 1
encephalopathy 9.46 1

Relevant External Links for IMMT

Genetic Association Database (GAD)
IMMT
Human Genome Epidemiology (HuGE) Navigator
IMMT
genes like me logo Genes that share disorders with IMMT: view

No data available for UniProtKB/Swiss-Prot for IMMT Gene

Publications for IMMT Gene

  1. Mitofilin is a transmembrane protein of the inner mitochondrial membrane expressed as two isoforms. (PMID: 9168817) Gieffers C. … Frey J. (Exp. Cell Res. 1997) 2 3 4 23
  2. A novel human gene that is preferentially transcribed in heart muscle. (PMID: 8039717) Icho T. … Tsuchida N. (Gene 1994) 2 3 4
  3. Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial DNA integrity. (PMID: 19762472) Rossi M.N. … Amati P. (J. Biol. Chem. 2009) 3 23
  4. The mitochondrial inner membrane protein mitofilin controls cristae morphology. (PMID: 15647377) John G.B. … Zha J. (Mol. Biol. Cell 2005) 3 23
  5. The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil- helix domain-containing protein 3 and 6 and DnaJC11. (PMID: 17624330) Xie J. … Capaldi R.A. (FEBS Lett. 2007) 3 23

Products for IMMT Gene

Sources for IMMT Gene

Back to Top

Content