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Aliases for IMMP1L Gene

Aliases for IMMP1L Gene

  • IMP1 Inner Mitochondrial Membrane Peptidase-Like (S. Cerevisiae) 2 3
  • IMP1 3 6
  • Mitochondrial Inner Membrane Protease Subunit 1 3
  • IMP1-Like Protein 4
  • EC 3.4.21.- 4
  • IMP1-LIKE 3

External Ids for IMMP1L Gene

Previous GeneCards Identifiers for IMMP1L Gene

  • GC11M031411
  • GC11M031148

Summaries for IMMP1L Gene

Entrez Gene Summary for IMMP1L Gene

  • The mitochondrial inner membrane peptidase (IMP) complex generates mature, active proteins in the mitochondrial intermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins. IMP1 and IMP2 (IMMP2L; MIM 605977) are the catalytic subunits of the IMP complex (Burri et al., 2005 [PubMed 15814844]).[supplied by OMIM, Sep 2008]

GeneCards Summary for IMMP1L Gene

IMMP1L (IMP1 Inner Mitochondrial Membrane Peptidase-Like (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Protein export. GO annotations related to this gene include serine-type peptidase activity.

UniProtKB/Swiss-Prot for IMMP1L Gene

  • Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMMP1L Gene

Genomics for IMMP1L Gene

Regulatory Elements for IMMP1L Gene

Genomic Location for IMMP1L Gene

31,432,401 bp from pter
31,509,645 bp from pter
77,245 bases
Minus strand

Genomic View for IMMP1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IMMP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMMP1L Gene

Proteins for IMMP1L Gene

  • Protein details for IMMP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial inner membrane protease subunit 1
    Protein Accession:
    Secondary Accessions:
    • D3DQZ7
    • Q96SH9

    Protein attributes for IMMP1L Gene

    166 amino acids
    Molecular mass:
    18504 Da
    Quaternary structure:
    • Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
    • Sequence=CAC39221.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for IMMP1L Gene

Proteomics data for IMMP1L Gene at MOPED

Post-translational modifications for IMMP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IMMP1L Gene

Domains for IMMP1L Gene

Suggested Antigen Peptide Sequences for IMMP1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96LU5
  • Belongs to the peptidase S26 family. IMP1 subfamily.
genes like me logo Genes that share domains with IMMP1L: view

No data available for Gene Families for IMMP1L Gene

Function for IMMP1L Gene

Molecular function for IMMP1L Gene

UniProtKB/Swiss-Prot Function: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.

Enzyme Numbers (IUBMB) for IMMP1L Gene

Gene Ontology (GO) - Molecular Function for IMMP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008236 serine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with IMMP1L: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IMMP1L Gene

Localization for IMMP1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for IMMP1L Gene

Mitochondrion inner membrane.

Subcellular locations from

Jensen Localization Image for IMMP1L Gene COMPARTMENTS Subcellular localization image for IMMP1L gene
Compartment Confidence
mitochondrion 4
cytosol 1
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IMMP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS 15814844
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with IMMP1L: view

Pathways for IMMP1L Gene

SuperPathways for IMMP1L Gene

Superpath Contained pathways
1 Protein export
genes like me logo Genes that share pathways with IMMP1L: view

Pathways by source for IMMP1L Gene

1 KEGG pathway for IMMP1L Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for IMMP1L Gene

Gene Ontology (GO) - Biological Process for IMMP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0006627 protein processing involved in protein targeting to mitochondrion IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with IMMP1L: view

Transcripts for IMMP1L Gene

Unigene Clusters for IMMP1L Gene

IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IMMP1L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IMMP1L Gene

No ASD Table

Relevant External Links for IMMP1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IMMP1L Gene

mRNA expression in normal human tissues for IMMP1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IMMP1L Gene

SOURCE GeneReport for Unigene cluster for IMMP1L Gene Hs.502223

genes like me logo Genes that share expressions with IMMP1L: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IMMP1L Gene

Orthologs for IMMP1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IMMP1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IMMP1L 35
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia IMMP1L 36
  • 90 (a)
(Canis familiaris)
Mammalia IMMP1L 35
  • 96.39 (n)
  • 96.99 (a)
  • 80 (a)
(Mus musculus)
Mammalia Immp1l 35
  • 91.57 (n)
  • 93.98 (a)
Immp1l 16
Immp1l 36
  • 94 (a)
(Monodelphis domestica)
Mammalia IMMP1L 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia IMMP1L 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Immp1l 35
  • 88.76 (n)
  • 90.96 (a)
(Gallus gallus)
Aves IMMP1L 35
  • 80.12 (n)
  • 81.93 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia IMMP1L 36
  • 82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34230 35
tropical clawed frog
(Silurana tropicalis)
Amphibia immp1l 35
  • 66.26 (n)
  • 67.88 (a)
Str.4206 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5528 35
(Danio rerio)
Actinopterygii immp1l 35
  • 67.89 (n)
  • 71.17 (a)
immp1l 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001682 35
  • 52.9 (n)
  • 50.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9240 35
  • 49.54 (n)
  • 52.05 (a)
CG9240 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea immp-1 35
  • 48.15 (n)
  • 44.44 (a)
immp-1 36
  • 41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR269C 35
  • 41.01 (n)
  • 37.41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IMP1 35
  • 46.34 (n)
  • 38.3 (a)
IMP1 36
  • 30 (a)
IMP1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07293g 35
  • 48.28 (n)
  • 40.69 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G53530 35
  • 46.93 (n)
  • 44.08 (a)
(Oryza sativa)
Liliopsida Os11g0620000 35
  • 45.78 (n)
  • 40 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC2D10.07c 35
  • 47.38 (n)
  • 40.71 (a)
Species with no ortholog for IMMP1L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IMMP1L Gene

Gene Tree for IMMP1L (if available)
Gene Tree for IMMP1L (if available)

Paralogs for IMMP1L Gene

Selected SIMAP similar genes for IMMP1L Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with IMMP1L: view

No data available for Paralogs for IMMP1L Gene

Variants for IMMP1L Gene

Sequence variations from dbSNP and Humsavar for IMMP1L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs563031 -- 31,507,697(-) tatgt(A/G)tcttt intron-variant
rs961627 -- 31,481,774(-) AAATG(C/T)TAGCT intron-variant
rs1060358 -- 31,497,731(-) ggctc(A/G)cgcct intron-variant
rs1137450 -- 31,497,688(-) GGTCA(A/G)GAGAT intron-variant
rs1137451 -- 31,497,554(-) aaccc(A/G)ggagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IMMP1L Gene

Variant ID Type Subtype PubMed ID
nsv529004 CNV Loss 19592680
esv2751022 CNV Loss 17911159
nsv897179 CNV Loss 21882294
nsv467785 CNV Loss 19166990
dgv1063n71 CNV Loss 21882294

Relevant External Links for IMMP1L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IMMP1L Gene

Disorders for IMMP1L Gene

(1) University of Copenhagen DISEASES for IMMP1L Gene

Relevant External Links for IMMP1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IMMP1L: view

No data available for UniProtKB/Swiss-Prot for IMMP1L Gene

Publications for IMMP1L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane. (PMID: 15814844) Burri L. … Lithgow T. (Mol. Biol. Cell 2005) 3 4
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for IMMP1L Gene

Sources for IMMP1L Gene

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