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Aliases for IMMP1L Gene

Aliases for IMMP1L Gene

  • Inner Mitochondrial Membrane Peptidase Subunit 1 2 3 5
  • IMP1 Inner Mitochondrial Membrane Peptidase-Like (S. Cerevisiae) 2
  • IMP1 Inner Mitochondrial Membrane Peptidase-Like 3
  • IMP1-Like Protein 4
  • EC 3.4.21.- 4
  • IMP1-LIKE 3
  • IMMP1 3
  • IMP1 3

External Ids for IMMP1L Gene

Previous HGNC Symbols for IMMP1L Gene

  • IMMP1

Previous GeneCards Identifiers for IMMP1L Gene

  • GC11M031411
  • GC11M031148

Summaries for IMMP1L Gene

Entrez Gene Summary for IMMP1L Gene

  • The mitochondrial inner membrane peptidase (IMP) complex generates mature, active proteins in the mitochondrial intermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins. IMP1 and IMP2 (IMMP2L; MIM 605977) are the catalytic subunits of the IMP complex (Burri et al., 2005 [PubMed 15814844]).[supplied by OMIM, Sep 2008]

GeneCards Summary for IMMP1L Gene

IMMP1L (Inner Mitochondrial Membrane Peptidase Subunit 1) is a Protein Coding gene. Among its related pathways are Protein export. GO annotations related to this gene include serine-type peptidase activity.

UniProtKB/Swiss-Prot for IMMP1L Gene

  • Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMMP1L Gene

Genomics for IMMP1L Gene

Regulatory Elements for IMMP1L Gene

Enhancers for IMMP1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IMMP1L on UCSC Golden Path with GeneCards custom track

Promoters for IMMP1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IMMP1L on UCSC Golden Path with GeneCards custom track

Genomic Location for IMMP1L Gene

Chromosome:
11
Start:
31,432,399 bp from pter
End:
31,509,645 bp from pter
Size:
77,247 bases
Orientation:
Minus strand

Genomic View for IMMP1L Gene

Genes around IMMP1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IMMP1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IMMP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMMP1L Gene

Proteins for IMMP1L Gene

  • Protein details for IMMP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LU5-IMP1L_HUMAN
    Recommended name:
    Mitochondrial inner membrane protease subunit 1
    Protein Accession:
    Q96LU5
    Secondary Accessions:
    • D3DQZ7
    • Q96SH9

    Protein attributes for IMMP1L Gene

    Size:
    166 amino acids
    Molecular mass:
    18504 Da
    Quaternary structure:
    • Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
    SequenceCaution:
    • Sequence=CAC39221.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for IMMP1L Gene

Proteomics data for IMMP1L Gene at MOPED

Post-translational modifications for IMMP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IMMP1L Gene

Domains & Families for IMMP1L Gene

Suggested Antigen Peptide Sequences for IMMP1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LU5

UniProtKB/Swiss-Prot:

IMP1L_HUMAN :
  • Belongs to the peptidase S26 family. IMP1 subfamily.
Family:
  • Belongs to the peptidase S26 family. IMP1 subfamily.
genes like me logo Genes that share domains with IMMP1L: view

No data available for Gene Families for IMMP1L Gene

Function for IMMP1L Gene

Molecular function for IMMP1L Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.

Enzyme Numbers (IUBMB) for IMMP1L Gene

genes like me logo Genes that share phenotypes with IMMP1L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IMMP1L

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IMMP1L Gene

Localization for IMMP1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for IMMP1L Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IMMP1L Gene COMPARTMENTS Subcellular localization image for IMMP1L gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IMMP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042720 mitochondrial inner membrane peptidase complex IBA --
genes like me logo Genes that share ontologies with IMMP1L: view

Pathways & Interactions for IMMP1L Gene

SuperPathways for IMMP1L Gene

Superpath Contained pathways
1 Protein export
genes like me logo Genes that share pathways with IMMP1L: view

Pathways by source for IMMP1L Gene

1 KEGG pathway for IMMP1L Gene

Interacting Proteins for IMMP1L Gene

Gene Ontology (GO) - Biological Process for IMMP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033108 mitochondrial respiratory chain complex assembly IBA --
genes like me logo Genes that share ontologies with IMMP1L: view

No data available for SIGNOR curated interactions for IMMP1L Gene

Drugs & Compounds for IMMP1L Gene

No Compound Related Data Available

Transcripts for IMMP1L Gene

Unigene Clusters for IMMP1L Gene

IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IMMP1L Gene

No ASD Table

Relevant External Links for IMMP1L Gene

GeneLoc Exon Structure for
IMMP1L
ECgene alternative splicing isoforms for
IMMP1L

Expression for IMMP1L Gene

mRNA expression in normal human tissues for IMMP1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IMMP1L Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IMMP1L Gene



SOURCE GeneReport for Unigene cluster for IMMP1L Gene Hs.502223

genes like me logo Genes that share expression patterns with IMMP1L: view

Protein tissue co-expression partners for IMMP1L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IMMP1L Gene

Orthologs for IMMP1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IMMP1L Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia IMMP1L 35
  • 96.39 (n)
  • 96.99 (a)
IMMP1L 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Immp1l 35
  • 91.57 (n)
  • 93.98 (a)
Immp1l 16
Immp1l 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IMMP1L 35
  • 100 (n)
  • 100 (a)
IMMP1L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Immp1l 35
  • 88.76 (n)
  • 90.96 (a)
cow
(Bos Taurus)
Mammalia IMMP1L 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IMMP1L 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IMMP1L 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves IMMP1L 35
  • 80.12 (n)
  • 81.93 (a)
IMMP1L 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IMMP1L 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia immp1l 35
  • 66.26 (n)
  • 67.88 (a)
Str.4206 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.34230 35
zebrafish
(Danio rerio)
Actinopterygii immp1l 35
  • 67.89 (n)
  • 71.17 (a)
immp1l 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5528 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001682 35
  • 52.9 (n)
  • 50.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9240 35
  • 49.54 (n)
  • 52.05 (a)
CG9240 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea immp-1 35
  • 48.15 (n)
  • 44.44 (a)
immp-1 36
  • 41 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR269C 35
  • 41.01 (n)
  • 37.41 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07293g 35
  • 48.28 (n)
  • 40.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IMP1 35
  • 46.34 (n)
  • 38.3 (a)
IMP1 36
  • 30 (a)
OneToOne
IMP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G53530 35
  • 46.93 (n)
  • 44.08 (a)
rice
(Oryza sativa)
Liliopsida Os11g0620000 35
  • 45.78 (n)
  • 40 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC2D10.07c 35
  • 47.38 (n)
  • 40.71 (a)
Species with no ortholog for IMMP1L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IMMP1L Gene

ENSEMBL:
Gene Tree for IMMP1L (if available)
TreeFam:
Gene Tree for IMMP1L (if available)

Paralogs for IMMP1L Gene

(1) SIMAP similar genes for IMMP1L Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with IMMP1L: view

No data available for Paralogs for IMMP1L Gene

Variants for IMMP1L Gene

Sequence variations from dbSNP and Humsavar for IMMP1L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs563031 -- 31,507,697(-) tatgt(A/G)tcttt intron-variant
rs961627 -- 31,481,774(-) AAATG(C/T)TAGCT intron-variant
rs1060358 -- 31,497,731(-) ggctc(A/G)cgcct intron-variant
rs1137450 -- 31,497,688(-) GGTCA(A/G)GAGAT intron-variant
rs1137451 -- 31,497,554(-) aaccc(A/G)ggagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IMMP1L Gene

Variant ID Type Subtype PubMed ID
nsv529004 CNV Loss 19592680
esv2751022 CNV Loss 17911159
nsv897179 CNV Loss 21882294
nsv467785 CNV Loss 19166990
dgv1063n71 CNV Loss 21882294

Variation tolerance for IMMP1L Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IMMP1L Gene

HapMap Linkage Disequilibrium report
IMMP1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IMMP1L Gene

Disorders for IMMP1L Gene

Relevant External Links for IMMP1L

Genetic Association Database (GAD)
IMMP1L
Human Genome Epidemiology (HuGE) Navigator
IMMP1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IMMP1L

No disorders were found for IMMP1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IMMP1L Gene

Publications for IMMP1L Gene

  1. Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane. (PMID: 15814844) Burri L. … Lithgow T. (Mol. Biol. Cell 2005) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide association and admixture analysis of glaucoma in the Women's Health Initiative. (PMID: 25027321) Hoffmann T.J. … Risch N. (Hum. Mol. Genet. 2014) 3
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for IMMP1L Gene

Sources for IMMP1L Gene

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