IMMP1L Gene
protein-coding GIFtS: 49
GCID: GC11M031411
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IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
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Aliases
for IMMP1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| IMP1 Inner Mitochondrial Membrane Peptidase-Like (S. Cerevisiae)1 2 | | Mitochondrial Inner Membrane Protease Subunit 12 | | IMP12 5 | | EC 3.4.21.-3 | | FLJ250591 | | IMP1-Like Protein3 | | IMP1-LIKE2 | | |
Export aliases for IMMP1L gene to outside databasesPrevious GC identifer: GC11M031148 |
Summaries
for IMMP1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IMMP1L:
The mitochondrial inner membrane peptidase (IMP) complex generates mature, active proteins in the mitochondrialintermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins.IMP1 and IMP2 (IMMP2L; MIM 605977) are the catalytic subunits of the IMP complex (Burri et al., 2005 (PubMed15814844)).(supplied by OMIM, Sep 2008)
UniProtKB/Swiss-Prot: IMP1L_HUMAN, Q96LU5Function: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrialmatrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO
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Genomic Views
for IMMP1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IMMP1L gene promoter:
E2F-3a E2F-4 E2F-5 E2F-2 Egr-4 E2F-1 E2F Nkx6-1 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for IMMP1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IMMP1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13IMMP1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M031411: view genomic region
(about GC identifiers)
Start:
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31,453,948 bp from pter |
End:
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31,531,192 bp from pter |
Size:
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77,245 bases |
Orientation:
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minus strand |
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Proteins
for IMMP1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IMP1L_HUMAN, Q96LU5 (See
protein sequence)Recommended Name: Mitochondrial inner membrane protease subunit 1 Size: 166 amino acids; 18504 Da
Subunit: Heterodimer of 2 subunits, IMMPL1 and IMMPL2 (By similarity)
Subcellular location: Mitochondrion inner membrane (Probable)
Sequence caution: Sequence=CAC39221.1; Type=Erroneous gene model prediction;
Secondary accessions: D3DQZ7 Q96SH9Explore the universe of human proteins at neXtProt for IMMP1L: NX_Q96LU5
IMMP1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_659418.1
ENSEMBL proteins: ENSP00000432670 ENSP00000435576 ENSP00000434280 ENSP00000432673 ENSP00000278200 ENSP00000432471 ENSP00000432001 ENSP00000432792
Human Recombinant Protein Products for IMMP1L:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
IMMP1L for ontologies About GeneDecksing
IMMP1L Antibody Products:
Assay Products for IMMP1L: |
Protein
Domains /
Families
for IMMP1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IMMP1L for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96LU5ProtoNet protein and cluster: Q96LU5 1 Blocks protein family: IPB000223 Bacterial leader peptidase 1 (S26) family signature
UniProtKB/Swiss-Prot: IMP1L_HUMAN, Q96LU5Similarity: Belongs to the peptidase S26 family. IMP1 subfamily |
Function
for IMMP1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: IMP1L_HUMAN, Q96LU5Function: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrialmatrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO Enzyme Number (IUBMB): EC 3.4.21.-1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0008236 | serine-type peptidase activity |
IEA | -- |
IMMP1L for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IMMP1L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IMMP1L (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IMMP1L (NM_144981) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IMMP1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMMP1L |
|
Pathways & Interactions
for IMMP1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein export | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for IMMP1L):
IMMP1L for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IMMP1L
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for IMMP1L (ENSP000002782004) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
IMMP1L for ontologies About GeneDecksing
|
Drugs & Compounds
for IMMP1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IMMP1L
Search CenterWatch for drugs/clinical trials and news about IMMP1L / IMP1L
|
Transcripts
for IMMP1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IMMP1L gene: NM_144981.1 Unigene Cluster for IMMP1L: IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) Hs.502223 [show with all ESTs]Unigene Representative Sequence: AK31161115 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000531331 ENST00000532287 ENST00000526776 ENST00000534812 ENST00000533512
ENST00000278200(uc001msy.1 uc001msz.1) ENST00000533642 ENST00000527184
ENST00000528161(uc009yjo.3 uc009yjp.3) ENST00000532624 ENST00000529749
ENST00000530023 ENST00000531693 ENST00000532668 ENST00000533921
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IMMP1L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IMMP1L (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IMMP1L (NM_144981) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IMMP1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMMP1L |
Additional cDNA sequence: AK057788.1 AK310496.1 AK311611.1 BC023595.2 16 DOTS entries: DT.92425236 DT.100751361 DT.446499 DT.95168892 DT.100680785 DT.120707002 DT.40236437 DT.92425232 DT.92425241 DT.95185356 DT.100751362 DT.92417760 DT.92425239 DT.95168895 DT.101955555 DT.412622 24/63 AceView cDNA sequences (see all 63): AI650959 AA534612 BC023595 AI990136 AA977197 AI475291 AA995349 AI829774 BF475373 AJ711425 AA192558 BE672969 AW471046 AI796750 AW241588 AW008627 AA788875 AI935556 NM_144981 AW076078 AK057788 AW295209 BF974021 BF433319
GeneLoc Exon Structure
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Expression
for IMMP1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IMMP1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAATTTATT
About this image
See IMMP1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IMMP1L
SOURCE GeneReport for Unigene cluster: Hs.502223
SABiosciences Expression via Pathway-Focused PCR Array including IMMP1L:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IMMP1L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IMMP1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IMMP1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IMMP1L |
Orthologs
for IMMP1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for IMMP1L gene from 9/28 species (see all 28) About this table
ENSEMBL Gene Tree for IMMP1L (if available)
TreeFam Gene Tree for IMMP1L (if available) |
Paralogs
for IMMP1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IMMP1L gene
1 SIMAP similar gene for IMMP1L using alignment to 5 protein entries: IMP1L_HUMAN (see all proteins):IMMP2L
IMMP1L for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for IMMP1L
PGOHUM00000242765 PGOHUM00000239931 PGOHUM00000237171 PGOHUM00000233099 PGOHUM00000241533
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Genomic Variants
for IMMP1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IMMP1L (31453948 - 31531192 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IMMP1L
1 CNV: 9180 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IMMP1L |
|
Disorders
/ Diseases
for IMMP1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IMMP1L for disorders About GeneDecksing
OMIM gene information: 612323
OMIM disorders: --
2  diseases for IMMP1L: About MalaCardsaniridia malaria
1 disease from the University of Copenhagen DISEASES database for IMMP1L:Aniridia Human Genome Epidemiology (HuGE) Navigator: IMMP1L (3 documents)
Export disorders for IMMP1L gene to outside databases
|
Publications
for IMMP1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IMMP1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with IMMP1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
- Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane. (PubMed id 15814844)1, 2 Burri L.... Lithgow T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for IMMP1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IMMP1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IMMP1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IMMP1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IMMP1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IMMP1L gene:
Search GeneIP for patents involving IMMP1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IMMP1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IMMP1L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IMMP1L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IMMP1L | | | OriGene Protein Over-expression Lysate for IMMP1L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IMMP1L | | OriGene 3'-UTR Clone for IMMP1L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IMMP1L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IMMP1L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IMMP1L | | OriGene Custom Protein Services for IMMP1L | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IMMP1L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IMMP1L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IMMP1L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IMMP1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IMMP1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IMMP1L |
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| | | | Search Tocris compounds for IMMP1L |
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 | | | IMMP1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibodies for IMMP1L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IMMP1L |
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