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ILVBL Gene

protein-coding   GIFtS: 58
GCID: GC19M015225

IlvB (Bacterial Acetolactate Synthase)-Like

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IlvB (Bacterial Acetolactate Synthase)-Like1 2     ILV2H2
AHAS2 3 5     Acetolactate Synthase-Like Protein2
Acetolactate Synthase Homolog1 2     EC 2.2.1.-3
IlvB-Like Protein2 3     EC 2.2.18
209L82     

External Ids:    HGNC: 60411   Entrez Gene: 109942   Ensembl: ENSG000001051357   OMIM: 6057705   UniProtKB: A1L0T03   

Export aliases for ILVBL gene to outside databases

Previous GC identifers: GC19M015604 GC19M015070 GC19M015087 GC19M015088 GC19M015089 GC19M014793


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ILVBL Gene:
The protein encoded by this gene shares similarity with several thiamine pyrophosphate-binding proteins identified
in bacteria, yeast, and plants. The highest degree of similarity is found with bacterial acetolactate synthases
(AHAS), which are enzymes that catalyze the first step in branched-chain amino acid biosynthesis. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ILVBL Gene:
ILVBL (ilvB (bacterial acetolactate synthase)-like) is a protein-coding gene. Diseases associated with ILVBL include rosacea, and cadasil. GO annotations related to this gene include thiamine pyrophosphate binding and magnesium ion binding. An important paralog of this gene is HACL1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ILVBL gene promoter:
         AML1a   Pax-5   RREB-1   AP-4   YY1   GATA-1   GATA-2   HEN1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidILVBL promoter sequence
   Search Chromatin IP Primers for ILVBL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ILVBL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

ILVBL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ILVBL gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M015225:  view genomic region     (about GC identifiers)

Start:
15,225,785 bp from pter      End:
15,236,596 bp from pter
Size:
10,812 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ILVBL_HUMAN, A1L0T0 (See protein sequence)
Recommended Name: Acetolactate synthase-like protein  
Size: 632 amino acids; 67868 Da
Cofactor: Binds 1 magnesium ion per subunit (By similarity)
Cofactor: Binds 1 thiamine pyrophosphate per subunit (By similarity)
Sequence caution: Sequence=AAC18916.1; Type=Erroneous gene model prediction; Sequence=AAH00109.1;
Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=AAI26914.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=AAI26914.1; Type=Miscellaneous discrepancy; Note=Sequence of
unknown origin at the C-terminus;
Secondary accessions: O43341 Q96F08 Q99651 Q9BWN5 Q9UEB2

Explore the universe of human proteins at neXtProt for ILVBL: NX_A1L0T0

Explore proteomics data for ILVBL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys577
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ILVBL (A1L0T0) (see all 8)
     LFRPLCK  QVQRCVE  GSNVACGL  QISREQVP 


    See ILVBL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006835.2  
    ENSEMBL proteins: 
     ENSP00000263383   ENSP00000470942   ENSP00000470834   ENSP00000434734   ENSP00000471762  
     ENSP00000435516   ENSP00000433355  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR012001 Thiamin_PyroP_enz_TPP-bd_dom
     IPR000399 TPP-bd_CS
     IPR012000 Thiamin_PyroP_enz_cen_dom
     IPR011766 TPP_enzyme-bd_C

    Graphical View of Domain Structure for InterPro Entry A1L0T0

    ProtoNet protein and cluster: A1L0T0

    UniProtKB/Swiss-Prot: ILVBL_HUMAN, A1L0T0
    Similarity: Belongs to the TPP enzyme family


    ILVBL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for ILVBL:
    bacterial acetolactate synthase-like,putatively involved in the branched chain aminoacid biosynthetic pathway

         Enzyme Numbers (IUBMB): EC 2.2.1.-1 EC 2.2.12

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0003674molecular_function ND--
    GO:0003824catalytic activity ----
    GO:0016740transferase activity IEA--
    GO:0030976thiamine pyrophosphate binding IEA--
         
    ILVBL for ontologies           About GeneDecksing


    Animal Models:
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    miRTarBase miRNAs that target ILVBL:
    hsa-mir-193b-3p (MIRT041275), hsa-mir-125b-5p (MIRT045928), hsa-mir-23b-3p (MIRT046288), hsa-mir-1 (MIRT023636)

    Block miRNA regulation of human, mouse, rat ILVBL using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate ILVBL:
    hsa-miR-299-5p hsa-miR-635
    SwitchGear 3'UTR luciferase reporter plasmidILVBL 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ILVBL_HUMAN, A1L0T0: Membrane; Single-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum2
    chloroplast1
    extracellular1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral component of membrane IEA--

    ILVBL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ILVBL
    Interactions:

        Search GeneGlobe Interaction Network for ILVBL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for ILVBL (A1L0T02, 3 ENSP000002633834) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC6P129562, 3, ENSP000003522574MINT-65376 I2D: score=5 STRING: ENSP00000352257
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    CLN3Q132863, ENSP000003530734I2D: score=2 STRING: ENSP00000353073
    ATG10Q9H0Y03I2D: score=1 
    ATG2AQ2TAZ03I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    ILVBL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ILVBL

    8 HMDB Compounds for ILVBL    About this table
    CompoundSynonyms CAS #PubMed Ids
    (S)-2-Aceto-2-hydroxybutanoic acid(S)-2-Aceto-2-hydroxybutanoate (see all 6)----
    (S)-2-Acetolactate(S)-2-Hydroxy-2-methyl-3-oxobutanoate (see all 2)----
    2-(a-Hydroxyethyl)thiamine diphosphate2-Hydroxyethyl-ThPP (see all 6)10055-47-7--
    2-Acetolactate ----
    L-Threonine(2S,3R)-(-)-Threonine (see all 21)72-19-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--
    Thiamine pyrophosphateTPP (see all 11)154-87-0--

    10 Novoseek inferred chemical compound relationships for ILVBL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetohydroxybutyrate 93.4 5 2077946 (2), 2345154 (1)
    imidazolinone 88.6 2 15896736 (1), 10802626 (1)
    acetolactate 86.7 6 2077946 (2), 2052541 (1), 2345154 (1)
    thiamin diphosphate 86.2 4 15640355 (1), 15236573 (1), 16111681 (1)
    acetoacetate 76.9 4 15640355 (1), 15958189 (1), 2345154 (1), 2077946 (1)
    sulfonylurea 74 2 15896736 (1), 19841951 (1)
    isoleucine 64 4 2052541 (1), 15640355 (1), 2345154 (1), 16111681 (1)
    valine 63.1 4 2052541 (1), 15640355 (1), 2345154 (1), 16111681 (1)
    pyruvate 59.5 8 15640355 (1), 15958189 (1), 20081005 (1), 2345154 (1) (see all 5)
    leucine 47.4 4 2052541 (1), 15640355 (1), 2345154 (1), 16111681 (1)



    ILVBL for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ILVBL gene (2 alternative transcripts): 
    NM_006844.4  NM_176826.1  

    Unigene Cluster for ILVBL:

    IlvB (bacterial acetolactate synthase)-like
    Hs.78880  [show with all ESTs]
    Unigene Representative Sequence: NM_006844
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533086 ENST00000263383(uc002nam.3) ENST00000534378 ENST00000534806
    ENST00000524779 ENST00000596093 ENST00000525880 ENST00000598709 ENST00000533148
    ENST00000531635 ENST00000600984 ENST00000527093(uc010dzx.1) ENST00000533747
    ENST00000599324
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    2 qRT-PCR Assays for microRNAs that regulate ILVBL:
    hsa-miR-299-5p hsa-miR-635
    SwitchGear 3'UTR luciferase reporter plasmidILVBL 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    BC000109.1 BC011722.2 BC011761.2 BC126913.1 U61263.1 

    16 DOTS entries:

    DT.216800  DT.91751477  DT.100699804  DT.95241518  DT.91751484  DT.121420826  DT.100789739  DT.86852268 
    DT.91751485  DT.95241519  DT.75103808  DT.121420792  DT.216801  DT.86845694  DT.102829574  DT.99983997 

    Selected AceView cDNA sequences (see all 278):

    CR609878 NM_006844 BE313450 CB163040 BM069523 AI418790 CR608986 BQ083166 
    AW501508 BM710253 CR615100 BC000109 AA283612 BE260769 BM676342 BM069758 
    BE261335 BE791510 AW615241 BQ706441 CF143887 BF590918 BM725588 BE795219 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ILVBL (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^
    SP1:              -     -     -     -           -                                                                                   -     -                     
    SP2:              -     -     -     -     -     -                                                                                                               
    SP3:                          -     -           -     -                                                                                                         
    SP4:              -     -     -     -     -     -                                                                                                               
    SP5:                                                                                                                                -     -                     

    ExUns: 15a · 15b ^ 16a · 16b ^ 17
    SP1:                    -         
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for ILVBL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ILVBL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGCCCAAG
    ILVBL Expression
    About this image

    ILVBL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ILVBL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.78880

    UniProtKB/Swiss-Prot: ILVBL_HUMAN, A1L0T0
    Tissue specificity: Expressed in all tissues tested, with highest expression in heart, pancreas and placenta

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ILVBL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ILVBL gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ilvbl1 , 5 ilvB (bacterial acetolactate synthase)-like1, 5 84.44(n)1
    86.39(a)1
      10 (39.72 cM)5
    2161361  NM_173751.41  NP_776112.11 
     785745005 
    chicken
    (Gallus gallus)
    Aves LOC1017475281 acetolactate synthase-like protein-like 62.1(n)
    60.57(a)
      101747528  XM_004950762.1  XP_004950819.1 
    lizard
    (Anolis carolinensis)
    Reptilia ILVBL6
    ilvB (bacterial acetolactate synthase)-like
    64(a)
    1 ↔ 1
    2(80210202-80223319)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ilvbl1 ilvB (bacterial acetolactate synthase)-like 62.9(n)
    66.07(a)
      100145261  NM_001126740.1  NP_001120212.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc663762 hypothetical protein MGC66376 73.64(n)   393639  BC057527.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T26C12.11 , 3 acetolactate synthase3
    T26C12.11
    56(a)3
    56.18(n)1
    56.97(a)1
      IV(3258923-3263303)3
    1770951  NM_067905.31  NP_500306.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    Hypothetical protein with low sequence identity to...
    24(a)
    1 → many
    V(118617-120299) YEL020C


    ENSEMBL Gene Tree for ILVBL (if available)
    TreeFam Gene Tree for ILVBL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ILVBL gene
    HACL12  
    1 SIMAP similar gene for ILVBL using alignment to 7 protein entries:     ILVBL_HUMAN (see all proteins):
    HACL1

    ILVBL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ILVBL (see all 409)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs673504601,2
    C--15225449(+) CCCCC-/C/CC  
            
    GAAAA
    1 -- ds50011NA 2
    rs2003529221,2
    --15226347(+) CTCCTC/GTCCTC 1 -- int10--------
    rs2022399041,2
    C--15226508(+) CAGGCC/TGCAGC 1 -- int10--------
    rs2015646531,2
    C--15226513(+) CGCAGC/GCTTCA 1 -- int10--------
    rs20742611,2
    C,F,A,H--15226611(+) GGTGAA/CATCTC 1 -- int124Minor allele frequency- C:0.33NS EA NA WA CSA EU 2725
    rs1931157291,2
    C,F--15226646(+) CCTCAG/AGCCAG 1 -- int11Minor allele frequency- A:0.01EU 1057
    rs1483786651,2
    C,F--15226719(+) CCCCAA/GACAGG 2 S F mis11Minor allele frequency- G:0.00NA 4552
    rs1432657971,2
    C--15226727(+) AGGCAC/TCAGAC 2 * W stg11Minor allele frequency- T:0.00NA 4552
    rs1137204971,2
    C--15226773(+) TCAGGG/ACCTAG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs355486531,2,,4
    C,F--15226825(+) CTGGCC/TGGCAC 2 Q R mis15Minor allele frequency- T:0.00NA WA 4632

    HapMap Linkage Disequilibrium report for ILVBL (15225785 - 15236596 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ILVBL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34154CNV Loss18971310
    nsv911130CNV Loss21882294
    nsv9668CNV Gain18304495
    dgv1058e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605770    OMIM disorders: --

    3 diseases for ILVBL:    About MalaCards
    rosacea    cadasil    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for ILVBL:
    Rosacea

    ILVBL for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ILVBL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberculosis 9.17 3 16111681 (3)


    Export disorders for ILVBL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ILVBL gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with ILVBL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human homolog of bacterial acetolactate synthase genes maps within the CADASIL critical region. (PubMed id 8954801)1, 2, 3 Joutel A....Tournier-Lasserve E. (Genomics 1996)
    2. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    3. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    4. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (Mol. Endocrinol. 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. (PubMed id 23246001)1 Xu Y....Ye Y. (Cell Rep 2012)
    10. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10994 HGNC: 6041 AceView: ILVBL Ensembl:ENSG00000105135 euGenes: HUgn10994
    ECgene: ILVBL H-InvDB: ILVBL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ILVBL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ILVBL gene:
    Search GeneIP for patents involving ILVBL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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