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Aliases for ILKAP Gene

Aliases for ILKAP Gene

  • ILK Associated Serine/Threonine Phosphatase 2 3 5
  • EC 3.1.3.16 4 63
  • Integrin-Linked Kinase-Associated Serine/Threonine Phosphatase 2C 2
  • Integrin-Linked Kinase-Associated Serine/Threonine Phosphatase 2
  • Integrin-Linked Kinase Associated Phosphatase 3
  • Protein Phosphatase, Mg2+/Mn2+ Dependent 1O 3
  • Protein Phosphatase 2c, Delta Isozyme 3
  • Mg2+/Mn2+ Dependent 1O 2
  • Protein Phosphatase 2
  • PP2C-DELTA 3
  • ILKAP2 3
  • ILKAP3 3
  • PPM1O 3

External Ids for ILKAP Gene

Previous GeneCards Identifiers for ILKAP Gene

  • GC02M237128
  • GC02M237760
  • GC02M239095
  • GC02M239365
  • GC02M238861
  • GC02M238743
  • GC02M230870
  • GC02M239079

Summaries for ILKAP Gene

Entrez Gene Summary for ILKAP Gene

  • The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for ILKAP Gene

ILKAP (ILK Associated Serine/Threonine Phosphatase) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1E.

UniProtKB/Swiss-Prot for ILKAP Gene

  • Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.

Gene Wiki entry for ILKAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ILKAP Gene

Genomics for ILKAP Gene

Regulatory Elements for ILKAP Gene

Enhancers for ILKAP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ILKAP on UCSC Golden Path with GeneCards custom track

Promoters for ILKAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ILKAP on UCSC Golden Path with GeneCards custom track

Genomic Location for ILKAP Gene

Chromosome:
2
Start:
238,170,401 bp from pter
End:
238,203,729 bp from pter
Size:
33,329 bases
Orientation:
Minus strand

Genomic View for ILKAP Gene

Genes around ILKAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ILKAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ILKAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ILKAP Gene

Proteins for ILKAP Gene

  • Protein details for ILKAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0C8-ILKAP_HUMAN
    Recommended name:
    Integrin-linked kinase-associated serine/threonine phosphatase 2C
    Protein Accession:
    Q9H0C8
    Secondary Accessions:
    • B3KM39

    Protein attributes for ILKAP Gene

    Size:
    392 amino acids
    Molecular mass:
    42907 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with ILK. Specific association with ILK is independent of the catalytic activity of either partner.

neXtProt entry for ILKAP Gene

Proteomics data for ILKAP Gene at MOPED

Post-translational modifications for ILKAP Gene

  • Ubiquitination at Lys 161
  • Modification sites at PhosphoSitePlus

Other Protein References for ILKAP Gene

Antibody Products

  • R&D Systems Antibodies for ILKAP (ILKAP/PP2C delta)

Domains & Families for ILKAP Gene

Gene Families for ILKAP Gene

Protein Domains for ILKAP Gene

Graphical View of Domain Structure for InterPro Entry

Q9H0C8

UniProtKB/Swiss-Prot:

ILKAP_HUMAN :
  • Contains 1 PPM-type phosphatase domain.
  • Belongs to the PP2C family.
Domain:
  • Contains 1 PPM-type phosphatase domain.
Family:
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with ILKAP: view

Function for ILKAP Gene

Molecular function for ILKAP Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited rather than stimulated by magnesium.
UniProtKB/Swiss-Prot Function:
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.

Enzyme Numbers (IUBMB) for ILKAP Gene

Gene Ontology (GO) - Molecular Function for ILKAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity IEA --
GO:0005515 protein binding IPI 11331582
genes like me logo Genes that share ontologies with ILKAP: view
genes like me logo Genes that share phenotypes with ILKAP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ILKAP

miRNA for ILKAP Gene

miRTarBase miRNAs that target ILKAP

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ILKAP Gene

Localization for ILKAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ILKAP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ILKAP Gene COMPARTMENTS Subcellular localization image for ILKAP gene
Compartment Confidence
cytosol 3
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for ILKAP Gene

Pathways & Interactions for ILKAP Gene

SuperPathways for ILKAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for ILKAP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ILKAP Gene

Drugs & Compounds for ILKAP Gene

(3) Drugs for ILKAP Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrochlorothiazide Approved Pharma Inhibition, Inhibitor 396
Manganese Pharma 32
Magnesium Nutra 0

(2) Additional Compounds for ILKAP Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with ILKAP: view

Transcripts for ILKAP Gene

Unigene Clusters for ILKAP Gene

Integrin-linked kinase-associated serine/threonine phosphatase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ILKAP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: -
SP6:
SP7: -
SP8: -

Relevant External Links for ILKAP Gene

GeneLoc Exon Structure for
ILKAP
ECgene alternative splicing isoforms for
ILKAP

Expression for ILKAP Gene

mRNA expression in normal human tissues for ILKAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ILKAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.5), Lymph node (7.8), and Breast (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ILKAP Gene



SOURCE GeneReport for Unigene cluster for ILKAP Gene Hs.92033

mRNA Expression by UniProt/SwissProt for ILKAP Gene

Q9H0C8-ILKAP_HUMAN
Tissue specificity: Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.
genes like me logo Genes that share expression patterns with ILKAP: view

Protein tissue co-expression partners for ILKAP Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ILKAP Gene

Orthologs for ILKAP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ILKAP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ILKAP 35
  • 89.52 (n)
  • 94.58 (a)
ILKAP 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ILKAP 35
  • 92.58 (n)
  • 96.68 (a)
ILKAP 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ilkap 35
  • 89.29 (n)
  • 95.15 (a)
Ilkap 16
Ilkap 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ILKAP 35
  • 99.74 (n)
  • 100 (a)
ILKAP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ilkap 35
  • 89.37 (n)
  • 95.15 (a)
oppossum
(Monodelphis domestica)
Mammalia ILKAP 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ILKAP 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves ILKAP 35
  • 77.72 (n)
  • 85.35 (a)
ILKAP 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ILKAP 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ilkap 35
  • 65.79 (n)
  • 66.47 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:162985 35
  • 63.76 (n)
  • 64.56 (a)
ILKAP 36
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F33A8.6 35
  • 48.8 (n)
  • 40.52 (a)
F33A8.6 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC1 36
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G18030 35
  • 50.44 (n)
  • 40.75 (a)
rice
(Oryza sativa)
Liliopsida Os09g0314400 35
  • 49.2 (n)
  • 40.59 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5410 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5800 36
  • 51 (a)
OneToOne
Species with no ortholog for ILKAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ILKAP Gene

ENSEMBL:
Gene Tree for ILKAP (if available)
TreeFam:
Gene Tree for ILKAP (if available)

Paralogs for ILKAP Gene

Paralogs for ILKAP Gene

(3) SIMAP similar genes for ILKAP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ILKAP: view

Variants for ILKAP Gene

Sequence variations from dbSNP and Humsavar for ILKAP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs34371548 - 238,189,953(+) TGGGA(C/T)ATTGA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1562336 -- 238,198,514(-) CATCT(G/T)TAATC intron-variant
rs935421 -- 238,188,767(-) TTATC(C/G)TTTTC intron-variant
rs2880131 -- 238,180,510(-) ACATT(G/T)CCAAA intron-variant
rs2880132 -- 238,174,335(-) GTAGG(C/T)TTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ILKAP Gene

Variant ID Type Subtype PubMed ID
nsv508894 CNV Insertion 20534489
nsv470525 CNV Loss 18288195
nsv517412 CNV Loss 19592680
nsv460147 CNV Loss 19166990

Variation tolerance for ILKAP Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ILKAP Gene

Disorders for ILKAP Gene

Relevant External Links for ILKAP

Genetic Association Database (GAD)
ILKAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ILKAP

No disorders were found for ILKAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ILKAP Gene

Publications for ILKAP Gene

  1. ILKAP regulates ILK signaling and inhibits anchorage-independent growth. (PMID: 14990992) Kumar A.S. … Hannigan G.E. (Oncogene 2004) 3 4 23 67
  2. Endometrial ILKAP expression among patients with endometriosis and its association with clinical characteristics. (PMID: 25872452) Shao G. … Liu P. (Int J Gynaecol Obstet 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for ILKAP Gene

Sources for ILKAP Gene

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