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ILKAP Gene

protein-coding   GIFtS: 55
GCID: GC02M239079

Integrin-Linked Kinase-Associated Serine/Threonine Phosphatase

(Previous name: integrin-linked kinase-associated serine/threonine phosphatase...)
  Search for ILKAP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin-Linked Kinase-Associated Serine/Threonine Phosphatase1 2     ILKAP32
Integrin-Linked Kinase-Associated Serine/Threonine Phosphatase 2C1 2     PP2C-DELTA2
EC 3.1.3.163 8     Integrin-Linked Kinase Associated Phosphatase2
ILKAP22     Protein Phosphatase 2c, Delta Isozyme2

External Ids:    HGNC: 155661   Entrez Gene: 808952   Ensembl: ENSG000001323237   UniProtKB: Q9H0C83   

Export aliases for ILKAP gene to outside databases

Previous GC identifers: GC02M237128 GC02M237760 GC02M239095 GC02M239365 GC02M238861 GC02M238743 GC02M230870


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ILKAP Gene:
The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can
interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the
kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling
process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling
pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for ILKAP Gene:
ILKAP (integrin-linked kinase-associated serine/threonine phosphatase) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1F.

UniProtKB/Swiss-Prot: ILKAP_HUMAN, Q9H0C8
Function: Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation
of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively
associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the
ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation

Gene Wiki entry for ILKAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ILKAP gene promoter:
         STAT1   ATF-2   STAT1beta   Olf-1   c-Jun   Pax-4a   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidILKAP promoter sequence
   Search Chromatin IP Primers for ILKAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ILKAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

ILKAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ILKAP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M239079:  view genomic region     (about GC identifiers)

Start:
239,079,042 bp from pter      End:
239,112,370 bp from pter
Size:
33,329 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ILKAP_HUMAN, Q9H0C8 (See protein sequence)
Recommended Name: Integrin-linked kinase-associated serine/threonine phosphatase 2C  
Size: 392 amino acids; 42907 Da
Cofactor: Binds 2 magnesium or manganese ions per subunit (By similarity)
Subunit: Interacts with ILK. Specific association with ILK is independent of the catalytic activity of either
partner
Secondary accessions: B3KM39

Explore the universe of human proteins at neXtProt for ILKAP: NX_Q9H0C8

Explore proteomics data for ILKAP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys161
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ILKAP (Q9H0C8) (see all 5)
     NLGDSRA  VFDGHGG  GDSRAILCR  LKGYVAERKGEREEMQDAHVILNDIT 


    See ILKAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_110395.1  
    ENSEMBL proteins: 
     ENSP00000254654   ENSP00000406254   ENSP00000395301  

    ILKAP Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for ILKAP
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPM: Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent

    3 InterPro protein domains:
     IPR001932 PP2C-like_dom
     IPR000222 PP2C_Mn2_Asp60_BS
     IPR015655 Protein_Pase_2C

    Graphical View of Domain Structure for InterPro Entry Q9H0C8

    ProtoNet protein and cluster: Q9H0C8

    1 Blocks protein domain: IPB000222 Protein phosphatase 2C subfamily

    UniProtKB/Swiss-Prot: ILKAP_HUMAN, Q9H0C8
    Similarity: Belongs to the PP2C family
    Similarity: Contains 1 PP2C-like domain


    Find genes that share domains with ILKAP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ILKAP_HUMAN, Q9H0C8
    Function: Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation
    of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively
    associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the
    ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
    Enzyme regulation: Inhibited rather than stimulated by magnesium

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004722protein serine/threonine phosphatase activity IEA--
    GO:0005515protein binding IPI11331582
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ILKAP           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ilkap):
     behavior/neurological  homeostasis/metabolism 

    Find genes that share phenotypes with ILKAP           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ILKAP
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ILKAP
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    miRNA
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    miRTarBase miRNAs that target ILKAP:
    hsa-mir-744-5p (MIRT037443), hsa-let-7a-5p (MIRT052596)

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    Addgene plasmids for ILKAP 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ILKAP_HUMAN, Q9H0C8: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with ILKAP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including ILKAP: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ILKAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ILKAP (Q9H0C81, 3 ENSP000002546544) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ILKQ134181, 3, ENSP000002994214EBI-2620298,EBI-747644 I2D: score=3 STRING: ENSP00000299421
    HGSO149643, ENSP000003312014I2D: score=1 STRING: ENSP00000331201
    ACVR1Q047713I2D: score=1 
    AXIN2Q9Y2T13I2D: score=1 
    BMPR1BO002383I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IEA--
    GO:0033262regulation of nuclear cell cycle DNA replication IEA--
    GO:0045786negative regulation of cell cycle ----

    Find genes that share ontologies with ILKAP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ILKAP

    2 HMDB Compounds for ILKAP    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ILKAP gene (2 alternative transcripts): 
    NM_030768.2  NM_176799.1  

    Unigene Cluster for ILKAP:

    Integrin-linked kinase-associated serine/threonine phosphatase
    Hs.92033  [show with all ESTs]
    Unigene Representative Sequence: BC050422
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254654(uc002vxv.3 uc010zns.2 uc021vyt.1 uc021vyu.1 uc010znt.1)
    ENST00000465131 ENST00000463129(uc002vxw.3) ENST00000450411 ENST00000466468
    ENST00000479400 ENST00000457149 ENST00000498727 ENST00000467133 ENST00000490837

    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ILKAP
      QuantiFast Probe-based Assays in human, mouse, rat ILKAP

    Additional mRNA sequence: 

    AK001043.1 AL136850.1 AY024365.1 BC006576.2 BC035746.1 BC050422.1 CR533533.1 FJ491380.1 
    FJ491381.1 HQ658059.1 HQ658060.1 

    14 DOTS entries:

    DT.313119  DT.97763058  DT.95082880  DT.313120  DT.40193121  DT.99968644  DT.120976684  DT.95082870 
    DT.40214385  DT.95217854  DT.100719339  DT.86995031  DT.97842908  DT.91653760 

    Selected AceView cDNA sequences (see all 175):

    AA595667 BU150871 CD676781 AI969275 F11116 CK902339 AA809125 BM768923 
    BM826962 CR617282 BQ026402 BU191859 BQ684678 CR602640 Z41850 AI586929 
    BU931014 BU166655 CR605643 BU553541 BX951135 BU177392 AI469699 NM_176799 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ILKAP (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:              -     -                       -     -     -                                         -                 -               
    SP2:                                      -     -     -     -                                         -                 -               
    SP3:                                                                                                  -                                 
    SP4:              -     -                                                                                                               
    SP5:                    -                                                                                                               


    ECgene alternative splicing isoforms for ILKAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ILKAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGTAAATA
    ILKAP Expression
    About this image

    ILKAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ILKAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.92033

    UniProtKB/Swiss-Prot: ILKAP_HUMAN, Q9H0C8
    Tissue specificity: Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in
    various smooth muscle tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including ILKAP: 
              Protein Phosphatases in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat ILKAP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ILKAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ILKAP gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ilkap1 , 5 integrin-linked kinase-associated serine/threonine more1, 5 89.29(n)1
    95.15(a)1
      1 (46.11 cM)5
    674441  NM_023343.21  NP_075832.11 
     913758315 
    chicken
    (Gallus gallus)
    Aves ILKAP1 integrin-linked kinase-associated serine/threonine more 77.72(n)
    85.35(a)
      424850  XM_004937010.1  XP_004937067.1 
    lizard
    (Anolis carolinensis)
    Reptilia ILKAP6
    integrin-linked kinase-associated serine/threonine...
    80(a)
    1 ↔ 1
    3(35340946-35358785)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ilkap1 integrin-linked kinase-associated serine/threonine more 65.79(n)
    66.47(a)
      595059  NM_001030496.1  NP_001025667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1629851 zgc:162985 63.76(n)
    64.56(a)
      100037350  NM_001089504.2  NP_001082973.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F33A8.61 F33A8.6 48.8(n)
    40.52(a)
      185220  NM_063969.2  NP_496370.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PTC16
    Type 2C protein phosphatase (PP2C); dephosphorylat...
    32(a)
    1 → many
    IV(439909-440754) YDL006W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G180301 AT1G18030 50.44(n)
    40.75(a)
      838383  NM_101665.2  NP_564045.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g03144001 Os09g0314400 49.2(n)
    40.59(a)
      4346692  NM_001069375.1  NP_001062840.1 


    ENSEMBL Gene Tree for ILKAP (if available)
    TreeFam Gene Tree for ILKAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ILKAP gene
    PPM1F2  PPM1K2  PPM1L2  PPM1E2  
    3 SIMAP similar genes for ILKAP using alignment to 5 protein entries:     ILKAP_HUMAN (see all proteins):
    ILKAP2    ILKAP3    PPM1F

    Find genes that share paralogs with ILKAP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ILKAP (see all 839)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs714027711,2
    C--238485539(+) AATAC-/A/AA  
            
    AAAAA
    1 -- us2k11NA 2
    rs1431169161,2
    C--239078656(+) TCTGAC/TGCATG 1 -- ds50010--------
    rs1512031431,2
    --239078797(+) CTTGAC/TTAACC 1 -- ds50010--------
    rs1403862151,2
    --239078852(+) CCAGGA/GTCATC 1 -- ds50010--------
    rs1503878111,2
    --239078885(+) ATGCCC/TGTGAA 1 -- ds50010--------
    rs1853457071,2
    --239078915(+) CAGCAA/GCCTGC 1 -- ds50010--------
    rs1379071051,2
    --239078916(+) AGCAGC/GCTGCA 1 -- ds50010--------
    rs1894061281,2
    --239078947(+) AGATGA/CCTATA 1 -- ds50010--------
    rs1457756561,2
    --239078971(+) GGAAAG/TACAGC 1 -- ds50010--------
    rs1387032721,2
    --239079017(+) GAGGTA/GCTCAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ILKAP (239079042 - 239112370 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ILKAP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508894CNV Insertion20534489
    nsv517412CNV Loss19592680
    nsv460147CNV Loss19166990
    nsv470525CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ILKAP
    DNA2.0 Custom Variant and Variant Library Synthesis for ILKAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ILKAP           About GenesLikeMe

    Genetic Association Database (GAD): ILKAP

    Export disorders for ILKAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ILKAP gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with ILKAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ILKAP regulates ILK signaling and inhibits anchorage-independent growth. (PubMed id 14990992)1, 2, 9 Kumar A.S....Hannigan G.E. (Oncogene 2004)
    2. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1, 4 Demirkan A....Schmitz G. (PLoS Genet. 2012)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1. (PubMed id 11331582)1, 2 Leung-Hagesteijn C.... Hannigan G.E. (EMBO J. 2001)
    9. Characterization of nuclear localization signal in the N terminus of integrin-linked kinase-associated phosphatase (ILKAP) and its essential role in the down-regulation of RSK2 protein signaling. (PubMed id 23329845)1 Zhou W....Xiao J. (J. Biol. Chem. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80895 HGNC: 15566 AceView: ILKAP Ensembl:ENSG00000132323 euGenes: HUgn80895
    ECgene: ILKAP H-InvDB: ILKAP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ILKAP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ILKAP gene:
    Search GeneIP for patents involving ILKAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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