Aliases for ILKAP Gene
External Ids for ILKAP Gene
Previous GeneCards Identifiers for ILKAP Gene
The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]
GeneCards Summary for ILKAP Gene
ILKAP (Integrin-Linked Kinase-Associated Serine/Threonine Phosphatase) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1E.
UniProtKB/Swiss-Prot for ILKAP Gene
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.