Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ILKAP Gene

Aliases for ILKAP Gene

  • Integrin-Linked Kinase-Associated Serine/Threonine Phosphatase 2 3
  • Integrin-Linked Kinase-Associated Serine/Threonine Phosphatase 2C 2 3
  • EC 3.1.3.16 4 63
  • Integrin-Linked Kinase Associated Phosphatase 3
  • Protein Phosphatase 2c, Delta Isozyme 3
  • PP2C-DELTA 3
  • ILKAP2 3
  • ILKAP3 3

External Ids for ILKAP Gene

Previous GeneCards Identifiers for ILKAP Gene

  • GC02M237128
  • GC02M237760
  • GC02M239095
  • GC02M239365
  • GC02M238861
  • GC02M238743
  • GC02M230870
  • GC02M239079

Summaries for ILKAP Gene

Entrez Gene Summary for ILKAP Gene

  • The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for ILKAP Gene

ILKAP (Integrin-Linked Kinase-Associated Serine/Threonine Phosphatase) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1E.

UniProtKB/Swiss-Prot for ILKAP Gene

  • Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.

Gene Wiki entry for ILKAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ILKAP Gene

Genomics for ILKAP Gene

Regulatory Elements for ILKAP Gene

Genomic Location for ILKAP Gene

Start:
238,170,401 bp from pter
End:
238,203,729 bp from pter
Size:
33,329 bases
Orientation:
Minus strand

Genomic View for ILKAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ILKAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ILKAP Gene

Proteins for ILKAP Gene

  • Protein details for ILKAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0C8-ILKAP_HUMAN
    Recommended name:
    Integrin-linked kinase-associated serine/threonine phosphatase 2C
    Protein Accession:
    Q9H0C8
    Secondary Accessions:
    • B3KM39

    Protein attributes for ILKAP Gene

    Size:
    392 amino acids
    Molecular mass:
    42907 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium or manganese ions per subunit.;
    Quaternary structure:
    • Interacts with ILK. Specific association with ILK is independent of the catalytic activity of either partner.

neXtProt entry for ILKAP Gene

Proteomics data for ILKAP Gene at MOPED

Post-translational modifications for ILKAP Gene

  • Ubiquitination at Lys161
  • Modification sites at PhosphoSitePlus

Other Protein References for ILKAP Gene

Domains for ILKAP Gene

Gene Families for ILKAP Gene

HGNC:
  • PPM :Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent

Protein Domains for ILKAP Gene

Graphical View of Domain Structure for InterPro Entry

Q9H0C8

UniProtKB/Swiss-Prot:

ILKAP_HUMAN :
  • Q9H0C8
Domain:
  • Contains 1 PPM-type phosphatase domain.
Family:
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with ILKAP: view

Function for ILKAP Gene

Molecular function for ILKAP Gene

UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited rather than stimulated by magnesium
UniProtKB/Swiss-Prot Function: Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.

Enzyme Numbers (IUBMB) for ILKAP Gene

Gene Ontology (GO) - Molecular Function for ILKAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004722 protein serine/threonine phosphatase activity IEA --
GO:0005515 protein binding IPI 11331582
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ILKAP: view

Phenotypes for ILKAP Gene

genes like me logo Genes that share phenotypes with ILKAP: view

Animal Model Products

CRISPR Products

miRNA for ILKAP Gene

miRTarBase miRNAs that target ILKAP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ILKAP

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ILKAP Gene

Localization for ILKAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ILKAP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ILKAP Gene COMPARTMENTS Subcellular localization image for ILKAP gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ILKAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ILKAP: view

Pathways for ILKAP Gene

SuperPathways for ILKAP Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ILKAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0008152 metabolic process --
GO:0033262 regulation of nuclear cell cycle DNA replication IEA --
genes like me logo Genes that share ontologies with ILKAP: view

No data available for Pathways by source for ILKAP Gene

Compounds for ILKAP Gene

(2) HMDB Compounds for ILKAP Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5
genes like me logo Genes that share compounds with ILKAP: view

Transcripts for ILKAP Gene

Unigene Clusters for ILKAP Gene

Integrin-linked kinase-associated serine/threonine phosphatase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ILKAP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ILKAP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: -
SP6:
SP7: -
SP8: -

Relevant External Links for ILKAP Gene

GeneLoc Exon Structure for
ILKAP
ECgene alternative splicing isoforms for
ILKAP

Expression for ILKAP Gene

mRNA expression in normal human tissues for ILKAP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ILKAP Gene

SOURCE GeneReport for Unigene cluster for ILKAP Gene Hs.92033

mRNA Expression by UniProt/SwissProt for ILKAP Gene

Q9H0C8-ILKAP_HUMAN
Tissue specificity: Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.
genes like me logo Genes that share expressions with ILKAP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ILKAP Gene

Orthologs for ILKAP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ILKAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ILKAP 35
  • 99.74 (n)
  • 100 (a)
ILKAP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ILKAP 35
  • 89.52 (n)
  • 94.58 (a)
ILKAP 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ILKAP 35
  • 92.58 (n)
  • 96.68 (a)
ILKAP 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ilkap 35
  • 89.29 (n)
  • 95.15 (a)
Ilkap 16
Ilkap 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ILKAP 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ILKAP 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ilkap 35
  • 89.37 (n)
  • 95.15 (a)
chicken
(Gallus gallus)
Aves ILKAP 35
  • 77.72 (n)
  • 85.35 (a)
ILKAP 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ILKAP 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ilkap 35
  • 65.79 (n)
  • 66.47 (a)
zebrafish
(Danio rerio)
Actinopterygii ILKAP 36
  • 63 (a)
OneToOne
zgc:162985 35
  • 63.76 (n)
  • 64.56 (a)
worm
(Caenorhabditis elegans)
Secernentea F33A8.6 35
  • 48.8 (n)
  • 40.52 (a)
F33A8.6 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC1 36
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G18030 35
  • 50.44 (n)
  • 40.75 (a)
rice
(Oryza sativa)
Liliopsida Os09g0314400 35
  • 49.2 (n)
  • 40.59 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5410 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5800 36
  • 51 (a)
OneToOne
Species with no ortholog for ILKAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ILKAP Gene

ENSEMBL:
Gene Tree for ILKAP (if available)
TreeFam:
Gene Tree for ILKAP (if available)

Paralogs for ILKAP Gene

Paralogs for ILKAP Gene

Selected SIMAP similar genes for ILKAP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ILKAP: view

Variants for ILKAP Gene

Sequence variations from dbSNP and Humsavar for ILKAP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs10385 -- 238,170,556(+) CACCA(C/T)CATCA missense, reference
rs12731 -- 238,179,271(-) CCATC(C/T)TTCCT intron-variant
rs935421 -- 238,188,767(-) TTATC(C/G)TTTTC intron-variant
rs1060757 -- 238,199,944(-) CCACA(C/T)CATCT intron-variant
rs1374387 -- 238,177,046(-) TGGGA(A/C)GTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ILKAP Gene

Variant ID Type Subtype PubMed ID
nsv508894 CNV Insertion 20534489
nsv470525 CNV Loss 18288195
nsv517412 CNV Loss 19592680
nsv460147 CNV Loss 19166990

Relevant External Links for ILKAP Gene

HapMap Linkage Disequilibrium report
ILKAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ILKAP Gene

Disorders for ILKAP Gene

Relevant External Links for ILKAP

Genetic Association Database (GAD)
ILKAP
genes like me logo Genes that share disorders with ILKAP: view

No data available for UniProtKB/Swiss-Prot for ILKAP Gene

Publications for ILKAP Gene

  1. ILKAP regulates ILK signaling and inhibits anchorage-independent growth. (PMID: 14990992) Kumar A.S. … Hannigan G.E. (Oncogene 2004) 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1. (PMID: 11331582) Leung-Hagesteijn C. … Hannigan G.E. (EMBO J. 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ILKAP Gene

  • Addgene plasmids for ILKAP

Sources for ILKAP Gene

Back to Top

Content