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Aliases for ILK Gene

Aliases for ILK Gene

  • Integrin Linked Kinase 2 3 5
  • 59 KDa Serine/Threonine-Protein Kinase 3 4
  • P59ILK 3 4
  • ILK-1 3 4
  • ILK-2 3 4
  • Epididymis Secretory Protein Li 28 3
  • Integrin-Linked Protein Kinase 3
  • Integrin-Linked Kinase-2 3
  • Integrin-Linked Kinase 2
  • EC 2.7.11.1 4
  • HEL-S-28 3
  • ILK1 4
  • ILK2 4
  • P59 3

External Ids for ILK Gene

Previous GeneCards Identifiers for ILK Gene

  • GC11P007367
  • GC11P007085
  • GC11P006584
  • GC11P006590
  • GC11P006560
  • GC11P006283

Summaries for ILK Gene

Entrez Gene Summary for ILK Gene

  • This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for ILK Gene

ILK (Integrin Linked Kinase) is a Protein Coding gene. Diseases associated with ILK include Scar Contracture and Focal Segmental Glomerulosclerosis. Among its related pathways are Focal Adhesion and Akt Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TNNI3K.

UniProtKB/Swiss-Prot for ILK Gene

  • Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715).

Gene Wiki entry for ILK Gene

Additional gene information for ILK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ILK Gene

Genomics for ILK Gene

Regulatory Elements for ILK Gene

Enhancers for ILK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H006601 1.4 ENCODE dbSUPER 37.5 +3.8 3789 12 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 RRP8 ILK FAM160A2 CAVIN3 DNHD1 ENSG00000254641 DCHS1 ENSG00000254400
GH11H006742 1.7 FANTOM5 Ensembl ENCODE dbSUPER 30.5 +141.5 141525 6 HDAC1 PKNOX1 RB1 NFRKB SIN3A YBX1 BATF TCF12 ZNF766 GATA2 ILK OR2AG2 CAVIN3 RRP8 ENSG00000254641 TAF10 OR10A4 APBB1 SMPD1 OR2AG1
GH11H007511 1.5 Ensembl ENCODE dbSUPER 20.4 +909.2 909222 3 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 GLIS2 ZNF143 ATF7 RUNX3 LOC100506258 ILK OLFML1 PPFIBP2
GH11H007495 1.1 Ensembl ENCODE dbSUPER 20.4 +892.6 892622 1 SRF NR2F1 JUNB ELF1 DPF2 IKZF1 NBN CREM IKZF2 ILK GC11M007483 OLFML1
GH11H006634 1.1 Ensembl ENCODE 18.1 +32.0 32029 3 RAD21 RARA EGR1 ETV6 CREM EGR2 REST NR2F2 ZNF592 SMARCA4 ILK MRPL17 RPL21P94 RRP8 DCHS1 ENSG00000255410
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ILK on UCSC Golden Path with GeneCards custom track

Promoters for ILK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036315 392 3001 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF207

Transcription factor binding sites by QIAGEN in the ILK gene promoter:

Genomic Location for ILK Gene

Chromosome:
11
Start:
6,603,708 bp from pter
End:
6,610,874 bp from pter
Size:
7,167 bases
Orientation:
Plus strand

Genomic View for ILK Gene

Genes around ILK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ILK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ILK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ILK Gene

Proteins for ILK Gene

  • Protein details for ILK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13418-ILK_HUMAN
    Recommended name:
    Integrin-linked protein kinase
    Protein Accession:
    Q13418
    Secondary Accessions:
    • B7Z1I0
    • B7Z418
    • D3DQU0
    • P57043
    • Q68DZ3

    Protein attributes for ILK Gene

    Size:
    452 amino acids
    Molecular mass:
    51419 Da
    Quaternary structure:
    • Interacts with FERMT2 (By similarity). Interacts with the cytoplasmic domain of ITGB1. Could also interact with integrin ITGB2, ITGB3 and/or ITGB5. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts with PARVA and PARVB; these compete for the same binding site. Interacts probably also with TGFB1I1. Interacts (via ANK repeats) with EPHA1 (via SAM domain); stimulated by EFNA1 but independent of the kinase activity of EPHA1. Interacts with LIMD2; leading to activate the protein kinase activity (PubMed:24590809).
    SequenceCaution:
    • Sequence=CAB94832.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Was originally thought to be distinct gene (ILK2) (PubMed:10871859).; Evidence={ECO:0000305 PubMed:10871859};

    Three dimensional structures from OCA and Proteopedia for ILK Gene

    Alternative splice isoforms for ILK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ILK Gene

Post-translational modifications for ILK Gene

  • Autophosphorylated on serine residues.
  • Ubiquitination at isoforms=285, isoforms=3165, and posLast=191191
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ILK (ILK)

No data available for DME Specific Peptides for ILK Gene

Domains & Families for ILK Gene

Gene Families for ILK Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q13418

UniProtKB/Swiss-Prot:

ILK_HUMAN :
  • A PH-like domain is involved in phosphatidylinositol phosphate binding.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Domain:
  • A PH-like domain is involved in phosphatidylinositol phosphate binding.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with ILK: view

Function for ILK Gene

Molecular function for ILK Gene

GENATLAS Biochemistry:
integrin-linked kinase,59kDa,widely expressed,potential regulator of integrin beta-1 mediated signal transduction,overlapping TAF2H by its 3end (divergently oriented)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated rapidly but transiently by both cell fibronectin interactions, as well as by insulin, in a PI3-K-dependent manner, likely via the binding of PtdIns(3,4,5)P3 with a PH-like domain of ILK. The protein kinase activity is stimulated by LIMD2 (PubMed:24590809).
UniProtKB/Swiss-Prot Function:
Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715).

Enzyme Numbers (IUBMB) for ILK Gene

Gene Ontology (GO) - Molecular Function for ILK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 9366252
GO:0004871 signal transducer activity IBA --
GO:0005178 integrin binding IEA --
genes like me logo Genes that share ontologies with ILK: view
genes like me logo Genes that share phenotypes with ILK: view

Animal Models for ILK Gene

MGI Knock Outs for ILK:

Animal Model Products

  • Taconic Biosciences Mouse Models for ILK

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ILK
  • Applied Biological Materials Clones for ILK
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ILK Gene

Localization for ILK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ILK Gene

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ILK gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 4
extracellular 2
mitochondrion 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (4)
  • Focal adhesion sites (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ILK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 colocalizes_with stress fiber IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with ILK: view

Pathways & Interactions for ILK Gene

genes like me logo Genes that share pathways with ILK: view

SIGNOR curated interactions for ILK Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for ILK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IBA --
GO:0001558 regulation of cell growth IEA --
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0001954 positive regulation of cell-matrix adhesion IEA --
GO:0003151 outflow tract morphogenesis IEA --
genes like me logo Genes that share ontologies with ILK: view

Drugs & Compounds for ILK Gene

(14) Drugs for ILK Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Nutra Agonist 0

(14) Additional Compounds for ILK Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ILK: view

Transcripts for ILK Gene

Unigene Clusters for ILK Gene

Integrin-linked kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ILK
  • Applied Biological Materials Clones for ILK
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ILK Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - -
SP9: - - - -
SP10: - - - -
SP11: - - - -
SP12: -
SP13:
SP14: - - - - - -
SP15: -
SP16:

ExUns: 14a · 14b ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for ILK Gene

GeneLoc Exon Structure for
ILK
ECgene alternative splicing isoforms for
ILK

Expression for ILK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ILK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ILK Gene

This gene is overexpressed in Platelet (15.1), Peripheral blood mononuclear cells (7.2), and Prostate (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ILK Gene



Protein tissue co-expression partners for ILK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ILK Gene:

ILK

SOURCE GeneReport for Unigene cluster for ILK Gene:

Hs.706355

mRNA Expression by UniProt/SwissProt for ILK Gene:

Q13418-ILK_HUMAN
Tissue specificity: Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.

Evidence on tissue expression from TISSUES for ILK Gene

  • Nervous system(4.9)
  • Intestine(4.6)
  • Muscle(3.3)
  • Heart(3.1)
  • Lung(3.1)
  • Kidney(3)
  • Blood(2.5)
  • Skin(2.5)
  • Lymph node(2.4)
  • Eye(2.2)
  • Liver(2.2)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with ILK: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ILK Gene

Orthologs for ILK Gene

This gene was present in the common ancestor of animals.

Orthologs for ILK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ILK 33 34
  • 99.56 (n)
oppossum
(Monodelphis domestica)
Mammalia ILK 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ILK 33 34
  • 94.03 (n)
dog
(Canis familiaris)
Mammalia ILK 33 34
  • 93.66 (n)
mouse
(Mus musculus)
Mammalia Ilk 16 34 33
  • 91.81 (n)
rat
(Rattus norvegicus)
Mammalia Ilk 33
  • 91.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 3 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ILK 33 34
  • 80.31 (n)
lizard
(Anolis carolinensis)
Reptilia ILK 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ilk 33
  • 76.77 (n)
Str.1347 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5978 33
zebrafish
(Danio rerio)
Actinopterygii ilk 33 34
  • 77.29 (n)
zgc65842 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.222 33
fruit fly
(Drosophila melanogaster)
Insecta Ilk 35 33 34
  • 60.48 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006573 33
  • 60.33 (n)
worm
(Caenorhabditis elegans)
Secernentea pat-4 33 34 35
  • 57.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 62 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11308 33
Species where no ortholog for ILK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ILK Gene

ENSEMBL:
Gene Tree for ILK (if available)
TreeFam:
Gene Tree for ILK (if available)

Paralogs for ILK Gene

genes like me logo Genes that share paralogs with ILK: view

Variants for ILK Gene

Sequence variations from dbSNP and Humsavar for ILK Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs139640491 Likely benign 6,608,777(+) CTGAG(A/C)GAGCT intron-variant, upstream-variant-2KB, reference, missense
rs145172848 Likely benign 6,609,712(+) CTTTT(A/G)CCTCC intron-variant, upstream-variant-2KB
rs757818130 Likely benign 6,608,208(+) GTACA(A/G)AAGGT intron-variant, nc-transcript-variant, reference, synonymous-codon
rs776123992 Likely benign 6,608,981(+) CCACT(A/G)TGGGA intron-variant, upstream-variant-2KB
rs876657478 Likely benign 6,609,166(+) CCCCT(A/G)CCCTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ILK Gene

Variant ID Type Subtype PubMed ID
esv996362 CNV deletion 20482838
nsv1035138 CNV gain 25217958
nsv553373 CNV loss 21841781
nsv825755 CNV gain 20364138

Variation tolerance for ILK Gene

Residual Variation Intolerance Score: 27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ILK Gene

Human Gene Mutation Database (HGMD)
ILK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ILK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ILK Gene

Disorders for ILK Gene

MalaCards: The human disease database

(7) MalaCards diseases for ILK Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
scar contracture
focal segmental glomerulosclerosis
  • opitz-kaveggia syndrome
lung cancer
  • lung cancer, protection against
ovarian cancer, somatic
  • adenocarcinoma, ovarian, somatic
stomach cancer
  • gastric cancer
- elite association - COSMIC cancer census association via MalaCards
Search ILK in MalaCards View complete list of genes associated with diseases

Relevant External Links for ILK

Genetic Association Database (GAD)
ILK
Human Genome Epidemiology (HuGE) Navigator
ILK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ILK
genes like me logo Genes that share disorders with ILK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ILK Gene

Publications for ILK Gene

  1. Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation. (PMID: 10871859) Janji B … Kieffer N (Oncogene 2000) 3 4 22 60
  2. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. (PMID: 9736715) Delcommenne M … Dedhar S (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 22 60
  3. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. (PMID: 8538749) Hannigan GE … Dedhar S (Nature 1996) 2 3 4 60
  4. Tumor expression of integrin-linked kinase (ILK) correlates with the expression of the E-cadherin repressor snail: an immunohistochemical study in ductal pancreatic adenocarcinoma. (PMID: 20091050) Schaeffer DF … Owen DA (Virchows Archiv : an international journal of pathology 2010) 3 22 60
  5. Hypoxia induces BMP-2 expression via ILK, Akt, mTOR, and HIF-1 pathways in osteoblasts. (PMID: 20232298) Tseng WP … Tang CH (Journal of cellular physiology 2010) 3 22 60

Products for ILK Gene

  • Addgene plasmids for ILK

Sources for ILK Gene

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