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ILK Gene

protein-coding GIFtS: 71

GC11P006581

integrin-linked kinase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp686F1765 ^²
EC 2.7.11.1 ^³
ILK-1 ^³
ILK-2 ^³
ILK1 ^³
ILK2 ^³
P59 ^², ⁵
p59ILK ^³

Descriptions
59 kDa serine/threonine-protein kinase ^³
integrin-linked kinase ^²

External Ids
HGNC: 6040¹
Entrez Gene: 3611²
UniProtKB: Q13418³
Ensembl: ENSG00000166333⁷

Search outside databases for aliases for ILK gene

Previous GC identifers: GC11P007367 GC11P007085 GC11P006584 GC11P006590 GC11P006560

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ILK:

Transduction of extracellular matrix signals through integrins influences intracellular and

extracellular functions, and appears to require interaction of integrin cytoplasmic domains with

cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1

integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which

associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase

regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript

variants encoding the same protein have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418

Function: Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May

act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex

ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth

factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin

substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3

integrin subunit on serine and threonine residues, but also AKT1 and GSK3B

Gene Wiki entry for ILK (Integrin-linked_kinase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ILK gene

Entrez Gene cytogenetic band: 11p15.5-p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4

ILK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P006581: (about GC identifiers)

Start:	6,581,540 bp from pter
End:	6,588,677 bp from pter
Size:	7,138 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418 (See protein sequence)

Recommended Name: Integrin-linked protein kinase

Size: 452 amino acids; 51419 Da

Subunit: Interacts with cytoplasmic domain of beta 1 subunit of integrin. Could also interacts with

beta 2, beta 3 and/or beta 5 subunit of integrin. Interacts (via ANK repeats) with LIMS1 and

LIMS2. Interacts with parvins and probably TGFB1I1

Subcellular location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein;

Cytoplasmic side

PDB structure from and Proteopedia :

2KBX (3D)

3F6Q (3D)

Secondary accessions: P57043 Q68DZ3

Post-translational modifications:

Autophosphorylated on serine residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001014794.1 NP_001014795.1 NP_004508.1

ENSEMBL proteins:

ENSP00000379975 ENSP00000299421

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Integrin linked ILK)
	Human Recombinant Proteins from Abnova (ILK)

OriGene Purified Recombinant Human Protein: ILK

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	NAS	--
GO:0005886	plasma membrane	IEA	--
GO:0005925	focal adhesion	IEA	--
GO:0030054	cell junction	IEA	--

About this table

Antibodies for ILK:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ILK
	Sigma-Aldrich Antibody Arrays and Antibodies for ILK
	R&D Systems Antibodies for ILK
	Cell Signaling Technology (CST) Antibodies for ILK (ILK1)
	Antibodies from Abcam (Integrin linked ILK), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ILK)
	Novus Biologicals Antibodies for ILK

Assays for ILK:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of ILK
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13418

ProtoNet protein and cluster: Q13418

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418

Domain: A PH-like domain is involved in phosphatidylinositol phosphate binding

Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family

Similarity: Contains 5 ANK repeats

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ILK)
		Millipore RNAi Products for the Analysis of ILK Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (ILK)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004517

Applied Biosystems Silencer® siRNAs for ILK

Sigma-Aldrich siRNA and siRNA Panels for ILK

Sigma-Aldrich shRNA Panels and shRNA for ILK

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ILK
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001014794
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001014794
untagged cDNA clones in CMV expression vector (see all 5): AL833496

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001014795

UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418

Function: Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May

act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex

ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth

factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin

substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3

integrin subunit on serine and threonine residues, but also AKT1 and GSK3B

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Stimulated rapidly but transiently by both cell fibronectin interactions, as

well as by insulin, in a PI3-K-dependent manner, likely via the binding of PtdIns(3,4,5)P3 with a

PH-like domain of ILK

Enzyme Number (IUBMB): EC 2.7.11.1

Genatlas biochemistry entry for ILK:

integrin-linked kinase,59kDa,widely expressed,potential regulator of integrin beta-1 mediated

signal transduction,overlapping TAF2H by its 3'end (divergently oriented)

9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ilk):

cellular	craniofacial	digestive/alimentary	embryogenesis	growth/size
lethality-prenatal/perinatal	limbs/digits/tail	respiratory system	skeleton

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IDA	10871859
GO:0004713	protein tyrosine kinase activity	IEA	--
GO:0005515	protein binding	IPI	16936772 17353931 17553790 18339839
GO:0005524	ATP binding	NAS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for ILK (Your Favorite Gene powered by Ingenuity) (see all 6 )

Germ Cell-Sertoli Cell Junction Signaling
Integrin Signaling
PTEN Signaling
Wnt/&beta
Endometrial Cancer Signaling

GeneDecks ILK for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ILK

5/85 Interacting proteins for ILK (Q13418^{1, 2} ENSP00000299421³) via UniProtKB, MINT, and/or STRING (see all 85 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PARVA	Q9NVD7², ENSP00000334008³	MINT-67103 STRING (score=.999)
PARVB	Q9HBI1¹, ENSP00000353924³	EBI-747644, EBI-1047679 STRING (score=.999)
CASP9	P55211¹, ENSP00000330237³	EBI-747644, EBI-516799 STRING (score=.963)
RICTOR	Q6R327¹, ENSP00000349959³	EBI-747644, EBI-1387196 STRING (score=.814)
ACP6	Q9NPH0¹	EBI-747644, EBI-717738

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001658	ureteric bud branching	IEA	--
GO:0006468	protein amino acid phosphorylation	IDA	10871859
GO:0007160	cell-matrix adhesion	NAS	--
GO:0007229	integrin-mediated signaling pathway	NAS	--
GO:0008284	positive regulation of cell proliferation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ILK
10/18 Novoseek chemical compound relationships for ILK gene (see all 18 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glycogen	60.72	27	12778079 (2), 15735038 (2), 15867245 (2), 16648553 (2) (see all 22)
phosphatidylinositol	60.55	16	16546979 (1), 17107957 (1), 11313365 (1), 16407822 (1) (see all 15)
threonine	56.11	21	15722199 (2), 11694518 (1), 17656471 (1), 10341284 (1) (see all 20)
phosphoinositide	44.65	12	12101188 (4), 17298394 (1), 12637511 (1), 17468516 (1) (see all 8)
chlorothalonil	38.67	3	2266108 (1)
wortmannin	35.70	2	15044083 (1), 14751515 (1)
tgf beta1	33.28	12	17187779 (7), 16643659 (2)
matrigel	25.08	3	12925691 (1), 16818815 (1)
tyrosine	21.59	10	19302919 (2), 14761892 (2), 19273203 (1), 12824296 (1) (see all 7)
okadaic acid	5.47	1	10896784 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ILK)
		Millipore RNAi Products for the Analysis of ILK Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (ILK)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004517

Sigma-Aldrich siRNA and siRNA Panels for ILK

Sigma-Aldrich shRNA Panels and shRNA for ILK

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001014794 NM_001014795 NM_004517

REFSEQ mRNAs for ILK gene (3 alternative transcripts):

NM_001014794.1 NM_001014795.1 NM_004517.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001014794 NM_001014795 NM_004517

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001014794
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001014794
                                 untagged cDNA clones in CMV expression vector (see all 5): AL833496

Additional cDNA sequence:

AJ277481.1 AK293474.1 AK296628.1 AK314843.1 BC001554.1 CR407673.1 CR598952.1 CR599632.1

CR601713.1 CR604127.1 CR608758.1 CR611887.1 CR615121.1 CR622983.1 CR624967.1 CR625625.1

CR625972.1 CR749220.1 U40282.1

24/31 DOTS entries (see all 31 ):

DT.92447057 DT.92447059 DT.452885 DT.100038213 DT.100886845 DT.95173144 DT.100886859 DT.95272900

DT.97802133 DT.100886848 DT.70101889 DT.95272905 DT.100886863 DT.100886855 DT.120709573 DT.449776

DT.100886843 DT.100886846 DT.100886862 DT.120709433 DT.100886860 DT.100886865 DT.100886868 DT.100886870

24/522 AceView cDNA sequences (see all 522 ):

AL555417 CR625972 CD515828 BQ222152 BG983192 CR625625 BU660724 BU734905

CR615121 BQ931548 CR608758 BM765458 BU177774 BQ672915 BG998721 BM705618

CA306218 BQ721237 CN482888 BQ936739 BU615476 BG983184 BU500956 CR604127

highest scoring ESTs for ILK:

U40282 AA035185 AA035186 AA084545 AA088224 AA135000 AA148200 AA157581 AA205999 AA281103

Unigene Cluster for ILK:

Integrin-linked kinase

Hs.706355 [show with all ESTs]

Unigene Representative Sequence: CR749220

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for ILK (see all 16 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	^	12a	·	12b	·	12c	^	13	^
SP1:											-		-				-										-						-
SP2:			-		-						-		-				-										-						-
SP3:			-										-				-										-						-
SP4:			-		-						-		-				-																-
SP5:			-								-		-				-										-						-

ExUns:	14a	·	14b	^	15
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ILK

2 Ensembl transcripts including schematic representations:

ENST00000396751 ENST00000299421

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ILK expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ILK

¹ / ² / ³

3 probe-sets matching ILK gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35365_at²^{, 3}	U95-A	2	1.00	0.88	1.00	1.00	U40282	1.00	1.00	1.00	1
201234_at²^{, 3}	U133-A	2	1.00	0.91	--	--	NM_004517	0.60	1.00	0.82	1
201234_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGAGGGATCA

SOURCE GeneReport for Unigene cluster: Hs.706355
Expression variation in blood from EXPOLDB for ILK
UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418
Tissue specificity: Highly expressed in heart followed by skeletal muscle, pancreas and kidney.
Weakly expressed in placenta, lung and liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ILK gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ILK¹	--	integrin-linked kinase	93.66(n) 99.78(a)	476836 XM_534040.2 XP_534040.1
chimpanzee (Pan troglodytes)	ILK¹	--	integrin-linked kinase	99.58(n) 100(a)	748941 XM_001164277.1 XP_001164277.1
cow (Bos taurus)	ILK¹	--	integrin-linked kinase	94.03(n) 99.34(a)	540207 NM_001034693.1 NP_001029865.1
rat (Rattus norvegicus)	Ilk¹	--	integrin linked kinase	91.37(n) 99.56(a)	170922 NM_133409.2 NP_596900.1
mouse (Mus musculus)	Ilk^{1, 5}	7⁵	integrin linked kinase^{1, 5}	91.52(n)¹ 99.12(a)¹	16202¹ NM_010562.1¹ NP_034692.1¹ AA511515⁵ AK002344⁵ (see all 24)

About this table Species with no ortholog for ILK

ENSEMBL Gene Tree for ILK

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ILK gene

TNNI3K² MOS²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/38 NCBI SNPs in ILK are shown (see all 38 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 89)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2292195^1,2	A,C,F,H	6587592(+)	`ATGGCC/TTTCCT`	3	A/A	syn¹		5		EA NA EU	1872
	rs1043388^1,2	C,F,H	6586241(+)	`GAACAC/TGGGAA`	3	H/H	syn¹ ese³		8		EA MN NA EU	2228
	rs1043390^1,2	A,C,F	6587409(+)	`ATGCCG/ATATGG`	3	P/P	syn¹		3		EA MN NA	1760
	rs2048092^1,2	A,C,F,H,O	6586106(+)	`TGTGTG/ACTCTT`	3	--	int¹		7		EA EU WA	2092
	rs2255538^1,2	A,C,F,H	6585618(+)	`ATATGG/ATGAAG`	3	--	int¹		8		EU EA WA	838
	rs2555175^1,2	A,C,F,H	6584107(-)	`TTTGAT/ATTTGC`	3	--	int¹		9		EA EU WA	2314
	rs2243625^1,2	A,C,F	6584565(+)	`TGGCAG/CGCAGC`	3	--	int¹		2		EA	180
	rs3741271^1,2	A,C,F	6585317(+)	`ACCAGA/CGCCAA`	3	--	int¹		2		EA	180
--	rs6578765^1,2	A,C	6583469(+)	`TCCTAC/TCCGCC`	3	--	int¹		0	--	--	--	--
--	rs7937456^1,2	A,C	6583668(+)	`CTCTCA/GATACA`	3	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ILK (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602366

10/40 Novoseek disease relationships for ILK gene (see all 40 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
renal fibrosis	47.25	4	12925691 (2), 17498677 (2)
carcinoma non-small cell lung	37.25	1	19176380 (1)
thyroid carcinoma anaplastic	31.58	6	16093430 (5)
familial adenomatous polyposis	31.56	2	16799642 (1), 12771992 (1)
tumors	28.38	73	17224516 (5), 12596061 (4), 15631637 (3), 15467740 (3) (see all 31)
ovarian cancer	27.08	18	14517840 (4), 17187779 (3), 12642872 (2), 12956424 (1) (see all 7)
metastasis	26.65	17	12596061 (3), 16836071 (3), 15300800 (2), 15631637 (1) (see all 8)
colon carcinoma	26.52	8	11244511 (4), 14555513 (1), 12191615 (1), 16278819 (1)
cancer	26.51	39	17143519 (3), 18505933 (3), 16314921 (2), 12884912 (2) (see all 19)
glioblastoma	24.41	14	15105053 (4), 15782140 (4), 16546979 (3), 18464290 (2)

About this table

Human Gene Mutation Database: ILK
Human Genome Epidemiology Navigator: ILK (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

Immune System Protein May Protect Against Insulin-Dependent Diabetes

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/254 PubMed articles for ILK gene (see all 254 ):

Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. (PubMed id 8538749)^{2, 3, 4} Hannigan G.E.... Dedhar S. (1996)
Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation. (PubMed id 10871859)^{1, 3, 4} Janji B.... Kieffer N. (2000)
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. (PubMed id 9736715)^{1, 3, 4} Delcommenne M.... Dedhar S. (1998)
The structural basis of integrin-linked kinase-PINCH interactions. (PubMed id 19074270)^{1, 3, 4} Chiswell B.P.... Calderwood D.A. (2008)
Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration. (PubMed id 12167643)^{1, 3, 4} Zhang Y.... Wu C. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Cell-substrate interactions and signaling through ILK. (PubMed id 10712922)^{3, 4} Dedhar S. (2000)
Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions. (PubMed id 11304546)^{1, 3} Nikolopoulos S.N. and Turner C.E. (2001)
Expression of integrin-linked kinase in the murine lens is consistent with its role in epithelial-mesenchymal transition of lens epithelial cells in vitro. (PubMed id 17563721)^{1, 3} Weaver M.S....Sage E.H. (2007)
Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival. (PubMed id 14555513)^{1, 3} Dai D.L....Li G. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3611	HGNC: 6040	AceView: ILK	Ensembl:ENSG00000166333	euGenes: HUgn3611
ECgene: ILK	H-InvDB: ILK

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ILK	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ILK
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ILK:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ILK-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ILK		Antibodies for ILK
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ILK		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ILK)
	Antibodies (ILK)
	Chimera RNAi (ILK)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ILK (ILK1)

	Recombinant Proteins (Integrin linked ILK)
	Antibodies (Integrin linked ILK)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ILK

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ILK

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ILK Gene at Home site.
Version 2.41.1
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ILK Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for ILK

Summaries
for ILK

Genomic Location
for ILK

Proteins
for ILK

Protein Domains/
Families
for ILK

Gene Function
for ILK

Pathways & Interactions
for ILK

Drugs & Compounds
for ILK

Transcripts
for ILK

Expression
for ILK

Orthologs
for ILK

Paralogs
for ILK

SNPs/Variants
for ILK

Disorders & Mutations
for ILK

Medical News
for ILK

Publications
for ILK

Search for ILK

Genome Databases showing ILK

Other Databases showing ILK

Specialized Databases showing ILK

Licensable Technologies
for ILK

Services
for ILK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ILK Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor ILK

Summariesfor ILK

Genomic Locationfor ILK

Proteinsfor ILK

Protein Domains/Familiesfor ILK

Gene Functionfor ILK

Pathways & Interactionsfor ILK

Drugs & Compoundsfor ILK

Transcriptsfor ILK

Expression for ILK

Orthologsfor ILK

Paralogsfor ILK

SNPs/Variantsfor ILK

Disorders & Mutationsfor ILK

Medical Newsfor ILK

Publicationsfor ILK

Search for ILK

Genome Databases showing ILK

Other Databases showing ILK

Specialized Databases showing ILK

Licensable Technologiesfor ILK

Servicesfor ILK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ILK

Summaries
for ILK

Genomic Location
for ILK

Proteins
for ILK

Protein Domains/
Families
for ILK

Gene Function
for ILK

Pathways & Interactions
for ILK

Drugs & Compounds
for ILK

Transcripts
for ILK

Expression
for ILK

Orthologs
for ILK

Paralogs
for ILK

SNPs/Variants
for ILK

Disorders & Mutations
for ILK

Medical News
for ILK

Publications
for ILK

Licensable Technologies
for ILK

Services
for ILK