ILK Gene
protein-coding GIFtS: 69
GCID: GC11P006581
|
|
integrin-linked kinase
| |
Aliases
for ILK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Integrin-Linked Kinase1 2 | | Integrin-Linked Kinase-22 | | 59 KDa Serine/Threonine-Protein Kinase2 3 | | Integrin-Linked Protein Kinase2 | | ILK-12 3 | | EC 2.7.11.13 | | ILK-22 3 | | ILK13 | | P59ILK1 | | ILK23 | | P592 5 | | |
Export aliases for ILK gene to outside databasesPrevious GC identifers: GC11P007367 GC11P007085 GC11P006584 GC11P006590 GC11P006560 GC11P006283 |
Summaries
for ILK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ILK:
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions,and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase(ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinasewith 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximalreceptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variantsencoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418Function: Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator ofinside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to beone of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cellarchitecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylatesbeta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B
Gene Wiki entry for ILK (Integrin-linked kinase)
|
Genomic Views
for ILK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ILK gene promoter:
ATF-2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for ILK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ILK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4ILK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P006581: view genomic region
(about GC identifiers)
Start:
|
6,624,961 bp from pter |
End:
|
6,632,102 bp from pter |
Size:
|
7,142 bases |
Orientation:
|
plus strand |
|
Proteins
for ILK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418 (See
protein sequence)Recommended Name: Integrin-linked protein kinase Size: 452 amino acids; 51419 Da
Subunit: Interacts with cytoplasmic domain of beta 1 subunit of integrin. Could also interacts with beta 2, beta 3and/or beta 5 subunit of integrin. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts with PARVA and PARVB;these compete for the same binding site. Interacts probably also with TGFB1I1. Interacts (via ANK repeats) with EPHA1(via SAM domain); stimulated by EFNA1 but independent of the kinase activity of EPHA1
Subcellular location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cellprojection, lamellipodium (By similarity). Cytoplasm, myofibril, sarcomere
Sequence caution: Sequence=CAB94832.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Was originallythought to be distinct gene (ILK2) (PubMed:10871859);
6 PDB 3D structures from  and Proteopedia  for ILK:2KBX (3D)
3F6Q (3D)
3IXE (3D)
3KMU (3D)
3KMW (3D)
3REP (3D)
Secondary accessions: D3DQU0 P57043 Q68DZ3Explore the universe of human proteins at neXtProt for ILK: NX_Q13418
Post-translational modifications:
Autophosphorylated on serine residues1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13418
ILK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001014794.1 NP_001014795.1 NP_004508.1
ENSEMBL proteins: ENSP00000299421 ENSP00000434492 ENSP00000432796 ENSP00000403487 ENSP00000432617 ENSP00000433129 ENSP00000436062 ENSP00000435323 ENSP00000379975 ENSP00000439606 Reactome Protein details: Q13418
Human Recombinant Protein Products:
Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14): About this table
ILK for ontologies About GeneDecksing
ILK Antibody Products:
Assay Products for ILK: |
Protein
Domains /
Families
for ILK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ILK for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q13418ProtoNet protein and cluster: Q13418 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418Domain: A PH-like domain is involved in phosphatidylinositol phosphate bindingSimilarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase familySimilarity: Contains 5 ANK repeatsSimilarity: Contains 1 protein kinase domain |
Function
for ILK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418Function: Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator ofinside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to beone of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cellarchitecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylatesbeta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3BCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Stimulated rapidly but transiently by both cell fibronectin interactions, as well as by insulin, ina PI3-K-dependent manner, likely via the binding of PtdIns(3,4,5)P3 with a PH-like domain of ILK Genatlas biochemistry entry for ILK:integrin-linked kinase,59kDa,widely expressed,potential regulator of integrin beta-1 mediated signaltransduction,overlapping TAF2H by its 3'end (divergently oriented)
Enzyme Number (IUBMB): EC 2.7.11.11
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ILK (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ILK (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ILK (NM_004517) | |  | Sino Biological Human cDNA Clone for ILK | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ILK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ILK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ILK |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
ILK for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for ILK:
Animal Models:
Mouse knock-out Ilktm2Ref for ILK
15/18 MGI mutant phenotypes (inferred from 10 alleles ) (MGI details for Ilk) (see all 18):
ILK for phenotypes About GeneDecksing
|
Pathways & Interactions
for ILK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Endometrial cancer | | | 2 | Sertoli-Sertoli Cell Junction Dynamics | | | 3 | Focal Adhesion | | | 4 | Cytoskeleton remodeling_Reverse signaling by ephrin B | | | 5 | Cell-cell junction organization | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 EMD Millipore Pathways for ILK
5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ILK
1 
Cell Signaling Technology (CST) Pathway for ILK
5  GeneGo (Thomson Reuters) Pathways for ILK
5  BioSystems Pathways for ILK
4 
Reactome Pathways for ILK
4 
Kegg Pathways (Kegg details for ILK):
ILK for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ILK
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/679 Interacting proteins for ILK (Q134181, 2, 3 ENSP000002994214) via UniProtKB, MINT, STRING, and/or I2D (see all 679)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CASP8 | Q147901, 3, ENSP000003512734 | EBI-747644,EBI-78060 I2D:
score=3 STRING: ENSP00000351273 | | CASP9 | P552111, 3, ENSP000003302374 | EBI-747644,EBI-516799 I2D:
score=3 STRING: ENSP00000330237 | | CKB | P122772, 3, ENSP000002991984 | MINT-8258588 I2D:
score=2 STRING: ENSP00000299198 | | COPG1 | Q9Y6782, 3, ENSP000003250024 | MINT-7945693 I2D:
score=2 STRING: ENSP00000325002 | | FANCI | Q9NVI12, 3, ENSP000003108424 | MINT-7945693 I2D:
score=2 STRING: ENSP00000310842 |
About this table
Gene Ontology (GO): 5/39 biological process terms (GO ID links to tree view) (see all 39): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001558 | regulation of cell growth |
-- | -- | | GO:0001658 | branching involved in ureteric bud morphogenesis |
IEA | -- | | GO:0001954 | positive regulation of cell-matrix adhesion |
IEA | -- | | GO:0006468 | protein phosphorylation |
IDA | 10871859 | | GO:0006469 | negative regulation of protein kinase activity |
IEA | -- |
ILK for ontologies About GeneDecksing
|
Drugs & Compounds
for ILK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ILK for compounds About GeneDecksing
 Browse Tocris compounds for ILK
2 HMDB Compounds for ILK About this table
10/26 Novoseek chemical compound relationships for ILK gene (see all 26) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glycogen |
60.8 |
28 |
12778079 (2), 15735038 (2), 15867245 (2), 16648553 (2) (see all 23) |
| phosphatidylinositol |
58.4 |
16 |
16546979 (1), 17107957 (1), 11313365 (1), 16407822 (1) (see all 15) |
| threonine |
55.9 |
23 |
15722199 (2), 11694518 (1), 17656471 (1), 19262169 (1) (see all 22) |
| phosphoinositide |
51 |
13 |
12101188 (4), 17298394 (1), 19920184 (1), 12637511 (1) (see all 9) |
| ly294002 |
50.4 |
6 |
15044083 (2), 17234779 (1), 14751515 (1), 16472257 (1) |
| serine |
43 |
23 |
15722199 (2), 11694518 (1), 17656471 (1), 19262169 (1) (see all 22) |
| rapamycin |
39 |
14 |
16014356 (1), 17588951 (1), 20232298 (1), 16397254 (1) (see all 8) |
| chlorothalonil |
35.6 |
3 |
2266108 (1) |
| matrigel |
33.9 |
3 |
12925691 (1), 16818815 (1) |
| wortmannin |
33 |
2 |
15044083 (1), 14751515 (1) |
Search CenterWatch for drugs/clinical trials and news about ILK
|
Transcripts
for ILK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ILK gene (3 alternative transcripts): NM_001014794.1 NM_001014795.1 NM_004517.2 Unigene Cluster for ILK: Integrin-linked kinase Hs.706355 [show with all ESTs]Unigene Representative Sequence: CR74922017 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000299421(uc001mee.3 uc001mef.3 uc010raq.2) ENST00000532063
ENST00000527327 ENST00000420936 ENST00000526114 ENST00000527394 ENST00000527121
ENST00000528995 ENST00000534565 ENST00000396751(uc001meh.3) ENST00000526318
ENST00000524735 ENST00000528784 ENST00000534706 ENST00000530016 ENST00000526711
ENST00000537806(uc010rap.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ILK (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ILK (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ILK (NM_004517) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ILK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ILK |
Additional cDNA sequence: AK293474.1 AK296628.1 AK314843.1 BC001554.1 CR407673.1 CR749220.1 U40282.1 24/30 DOTS entries (see all 30): DT.92447057 DT.92447059 DT.452885 DT.100038213 DT.100886845 DT.95173144 DT.100886859 DT.95272900 DT.97802133 DT.100886848 DT.70101889 DT.95272905 DT.100886863 DT.100886855 DT.120709573 DT.449776 DT.100886843 DT.100886846 DT.100886862 DT.120709433 DT.100886860 DT.100886865 DT.100886868 DT.100886870 24/522 AceView cDNA sequences (see all 522): CR625625 CR598952 AI125341 CK430065 BG998721 BQ433254 BG983184 BU615476 BU526649 BU628446 BM705185 AI752153 CR608758 AA300589 BX419993 CR611887 BG983192 AI807533 CR624967 CR604127 CF138777 CD742911 BQ721237 CA306218
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for ILK (see all 16) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | | | | | - | | - | | | | - | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | | | | | | | - | | | | - | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | | | | | | | - | | - | | | | - | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | |
| ExUns: | 14a | · | 14b | ^ | 15 |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for ILK
|
Expression
for ILK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ILK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGGGATCA
About this image
See ILK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ILK
SOURCE GeneReport for Unigene cluster: Hs.706355
UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418Tissue specificity: Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed inplacenta, lung and liver
SABiosciences Expression via Pathway-Focused PCR Arrays including ILK (see all 8):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ILK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ILK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ILK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ILK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ILK |
Orthologs
for ILK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ILK gene from 6/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ILK1 |
integrin-linked kinase |
80.31(n)
90.71(a) |
|
374018 NM_204194.1 NP_989525.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ILK6 |
-- |
88(a) |
1 ↔ 1 |
GL345104.1(1055-7994) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.59782 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.15(n) |
|
BU916167.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc658422 |
hypothetical protein MGC65842 |
79.11(n) |
|
393543 BC056593.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ilk1 , 3 |
integrin-mediated signaling pathway protein
serine/threonine more3
Integrin linked kinase1 |
59(a)3
60.48(n)1
60.63(a)1 |
|
78C23
535731 NM_080262.31 NP_525001.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
pat-41 , 3 |
integrin-linked kinase3
Protein PAT-41 |
58(a)3
57.85(n)1
58.97(a)1 |
|
III(89525-91902)3
1751751 NM_064738.41 NP_497139.11 |
ENSEMBL Gene Tree for ILK (if available)
TreeFam Gene Tree for ILK (if available) |
Paralogs
for ILK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ILK gene
- MAP3K112 MAP3K122 KIAA18042 RAF12 KSR22 KSR12 BRAF2 MOS2
- MAP3K102 MAP3K92 ARAF2 MAP3K72 MAP3K7CL2 TNNI3K2 ZAK2 MAP3K132
10 SIMAP similar genes for ILK using alignment to 7 protein entries: ILK_HUMAN (see all proteins):ANKRD42 ANKRD44 ANKRD54 HACE1 RAI14 GABPB1
IkBa ANKRD65 tec ANKRD46
ILK for paralogs About GeneDecksing
|
Genomic Variants
for ILK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ILK (6624961 - 6632102 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ILK: --
Human Gene Mutation Database (HGMD): ILK
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ILK |
|
Disorders
/ Diseases
for ILK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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ILK for disorders About GeneDecksing
OMIM gene information: 602366
OMIM disorders: --
20/63  diseases for ILK (see all 63): About MalaCardsfamilial adenomatous polyposis proliferative vitreoretinopathy ataxia telangiectasia dilated cardiomyopathy
squamous cell carcinoma b-cell lymphomas laryngeal squamous cell carcinoma squamous cell carcinoma of the head and neck
aortic aneurysm polyposis vitreoretinopathy carcinoma
basal cell carcinoma acute myeloid leukemia intrahepatic cholangiocarcinoma myeloid leukemia
laryngitis liver cirrhosis renal cell carcinoma cardiomyopathy
1 disease from the University of Copenhagen DISEASES database for ILK:Cancer 10/43 Novoseek disease relationships for ILK gene (see all 43) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| renal fibrosis |
49.7 |
4 |
12925691 (2), 17498677 (2) |
| carcinoma non-small cell lung |
34.4 |
1 |
19176380 (1) |
| tumors |
32.8 |
94 |
17224516 (5), 19923885 (5), 12596061 (4), 15631637 (3) (see all 39) |
| cancer |
30.9 |
55 |
19895269 (3), 17143519 (3), 18505933 (3), 19409087 (2) (see all 27) |
| ovarian cancer |
29.9 |
20 |
14517840 (4), 17187779 (3), 12642872 (2), 19334037 (2) (see all 8) |
| metastasis |
29.4 |
18 |
12596061 (3), 16836071 (3), 15300800 (2), 15631637 (1) (see all 9) |
| familial adenomatous polyposis |
28.9 |
2 |
16799642 (1), 12771992 (1) |
| thyroid carcinoma anaplastic |
28.4 |
6 |
16093430 (5) |
| prostate carcinoma |
27.8 |
4 |
14990992 (1), 9681506 (1), 10716737 (1) |
| prostate cancer |
25.4 |
12 |
15704679 (4), 15870868 (1), 15782140 (1), 10716737 (1) (see all 6) |
Human Genome Epidemiology (HuGE) Navigator: ILK (1 document)
Export disorders for ILK gene to outside databases
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Publications
for ILK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ILK gene, integrated from 9 sources (see all 342):
(articles sorted by number of sources associating them with ILK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. (PubMed id 8538749)1, 2, 3 Hannigan G.E.... Dedhar S. (1996)
- Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation. (PubMed id 10871859)1, 2, 9 Janji B.... Kieffer N. (2000)
- Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. (PubMed id 9736715)1, 2, 9 Delcommenne M.... Dedhar S. (1998)
- The pseudoactive site of ILK is essential for its bin ding to alpha-Parvin and localization to focal adhesions. (PubMed id 20005845)1, 2, 9 Fukuda K....Qin J. (2009)
- Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. (PubMed id 15284246)1, 2, 9 Zhang Y....Wu C. (2004)
- A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. (PubMed id 11402068)1, 2, 9 Yamaji S.... Ishigatsubo Y. (2001)
- The structural basis of integrin-linked kinase-PINCH interactions. (PubMed id 19074270)1, 2, 9 Chiswell B.P.... Calderwood D.A. (2008)
- EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. (PubMed id 19118217)1, 2, 9 Yamazaki T....Maru Y. (2009)
- Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration. (PubMed id 12167643)1, 2, 9 Zhang Y.... Wu C. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for ILK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing ILK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing ILK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ILK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
About This Section
| Patent Information for ILK gene:
Search GeneIP for patents involving ILK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ILK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|
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 | |
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| | |  | OriGene Antibodies for ILK | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ILK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ILK | | | OriGene Protein Over-expression Lysate for ILK | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ILK | | OriGene 3'-UTR Clone for ILK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ILK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ILK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ILK | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ILK | | OriGene Custom Protein Services for ILK | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ILK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ILK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ILK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ILK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ILK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ILK |
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| | | | Search Tocris compounds for ILK |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ILK |
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