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Aliases for ILK Gene

Aliases for ILK Gene

  • Integrin-Linked Kinase 2 3
  • 59 KDa Serine/Threonine-Protein Kinase 3 4
  • P59ILK 3 4
  • ILK-1 3 4
  • ILK-2 3 4
  • P59 3 6
  • Epididymis Secretory Protein Li 28 3
  • Integrin-Linked Protein Kinase 3
  • Integrin-Linked Kinase-2 3
  • EC 2.7.11.1 4
  • HEL-S-28 3
  • ILK1 4
  • ILK2 4

External Ids for ILK Gene

Previous GeneCards Identifiers for ILK Gene

  • GC11P007367
  • GC11P007085
  • GC11P006584
  • GC11P006590
  • GC11P006560
  • GC11P006283

Summaries for ILK Gene

Entrez Gene Summary for ILK Gene

  • This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for ILK Gene

ILK (Integrin-Linked Kinase) is a Protein Coding gene. Diseases associated with ILK include scar contracture. Among its related pathways are Akt Signaling and ERK Signaling. GO annotations related to this gene include protein serine/threonine kinase activity and signal transducer activity. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot for ILK Gene

  • Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B

Gene Wiki entry for ILK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ILK Gene

Genomics for ILK Gene

Regulatory Elements for ILK Gene

Transcription factor binding sites by QIAGEN in the ILK gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ILK Gene

Start:
6,603,708 bp from pter
End:
6,610,874 bp from pter
Size:
7,167 bases
Orientation:
Plus strand

Genomic View for ILK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ILK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ILK Gene

Proteins for ILK Gene

  • Protein details for ILK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13418-ILK_HUMAN
    Recommended name:
    Integrin-linked protein kinase
    Protein Accession:
    Q13418
    Secondary Accessions:
    • B7Z1I0
    • B7Z418
    • D3DQU0
    • P57043
    • Q68DZ3

    Protein attributes for ILK Gene

    Size:
    452 amino acids
    Molecular mass:
    51419 Da
    Quaternary structure:
    • Interacts with FERMT2 (By similarity). Interacts with the cytoplasmic domain of ITGB1. Could also interact with integrin ITGB2, ITGB3 and/or ITGB5. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts with PARVA and PARVB; these compete for the same binding site. Interacts probably also with TGFB1I1. Interacts (via ANK repeats) with EPHA1 (via SAM domain); stimulated by EFNA1 but independent of the kinase activity of EPHA1.
    SequenceCaution:
    • Sequence=CAB94832.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Was originally thought to be distinct gene (ILK2) (PubMed:10871859).; Evidence={ECO:0000305 PubMed:10871859};

    Three dimensional structures from OCA and Proteopedia for ILK Gene

    Alternative splice isoforms for ILK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ILK Gene

Proteomics data for ILK Gene at MOPED

Post-translational modifications for ILK Gene

  • Autophosphorylated on serine residues
  • Ubiquitination at Lys85, Lys165, Lys191, and Lys220
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ILK (ILK)

No data available for DME Specific Peptides for ILK Gene

Domains for ILK Gene

Gene Families for ILK Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q13418

UniProtKB/Swiss-Prot:

ILK_HUMAN :
  • Q13418
Domain:
  • A PH-like domain is involved in phosphatidylinositol phosphate binding.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with ILK: view

Function for ILK Gene

Molecular function for ILK Gene

GENATLAS Biochemistry: integrin-linked kinase,59kDa,widely expressed,potential regulator of integrin beta-1 mediated signal transduction,overlapping TAF2H by its 3end (divergently oriented)
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Stimulated rapidly but transiently by both cell fibronectin interactions, as well as by insulin, in a PI3-K-dependent manner, likely via the binding of PtdIns(3,4,5)P3 with a PH-like domain of ILK
UniProtKB/Swiss-Prot Function: Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B

Enzyme Numbers (IUBMB) for ILK Gene

Gene Ontology (GO) - Molecular Function for ILK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 10871859
GO:0004713 protein tyrosine kinase activity --
GO:0004871 signal transducer activity IEA --
GO:0005178 integrin binding IEA --
genes like me logo Genes that share ontologies with ILK: view
genes like me logo Genes that share phenotypes with ILK: view

Animal Models for ILK Gene

MGI Knock Outs for ILK:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ILK

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for ILK Gene

Localization for ILK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ILK Gene

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ILK Gene COMPARTMENTS Subcellular localization image for ILK gene
Compartment Confidence
plasma membrane 5
cytosol 4
cytoskeleton 3
extracellular 2
mitochondrion 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ILK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ILK: view

Pathways for ILK Gene

genes like me logo Genes that share pathways with ILK: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ILK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth --
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0001954 positive regulation of cell-matrix adhesion IEA --
GO:0006468 protein phosphorylation IDA 10871859
GO:0006469 negative regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with ILK: view

Compounds for ILK Gene

(2) HMDB Compounds for ILK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(26) Novoseek inferred chemical compound relationships for ILK Gene

Compound -log(P) Hits PubMed IDs
glycogen 60.8 27
phosphatidylinositol 58.4 15
threonine 55.9 23
phosphoinositide 51 12
ly294002 50.4 5
genes like me logo Genes that share compounds with ILK: view

Transcripts for ILK Gene

Unigene Clusters for ILK Gene

Integrin-linked kinase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ILK

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ILK Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - -
SP9: - - - -
SP10: - - - -
SP11: - - - -
SP12: -
SP13:
SP14: - - - - - -
SP15: -
SP16:

ExUns: 14a · 14b ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for ILK Gene

GeneLoc Exon Structure for
ILK
ECgene alternative splicing isoforms for
ILK

Expression for ILK Gene

mRNA expression in normal human tissues for ILK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ILK Gene

SOURCE GeneReport for Unigene cluster for ILK Gene Hs.706355

mRNA Expression by UniProt/SwissProt for ILK Gene

Q13418-ILK_HUMAN
Tissue specificity: Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver
genes like me logo Genes that share expressions with ILK: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ILK Gene

Orthologs for ILK Gene

This gene was present in the common ancestor of animals.

Orthologs for ILK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ILK 35
  • 99.56 (n)
  • 100 (a)
ILK 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ILK 35
  • 94.03 (n)
  • 99.34 (a)
ILK 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ILK 35
  • 93.66 (n)
  • 99.78 (a)
ILK 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ilk 35
  • 91.81 (n)
  • 99.56 (a)
Ilk 16
Ilk 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ILK 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 3 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ilk 35
  • 91.37 (n)
  • 99.56 (a)
chicken
(Gallus gallus)
Aves ILK 35
  • 80.31 (n)
  • 90.71 (a)
ILK 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ILK 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5978 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ilk 35
  • 76.77 (n)
  • 88.5 (a)
Str.1347 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.222 35
zebrafish
(Danio rerio)
Actinopterygii ilk 35
  • 77.29 (n)
  • 86.73 (a)
ilk 36
  • 87 (a)
OneToOne
zgc65842 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006573 35
  • 60.33 (n)
  • 60.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ilk 35
  • 60.48 (n)
  • 60.63 (a)
Ilk 36
  • 60 (a)
OneToOne
Ilk 37
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea pat-4 35
  • 57.85 (n)
  • 58.97 (a)
pat-4 36
  • 56 (a)
OneToOne
pat-4 37
  • 58 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11308 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToOne
Species with no ortholog for ILK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ILK Gene

ENSEMBL:
Gene Tree for ILK (if available)
TreeFam:
Gene Tree for ILK (if available)

Paralogs for ILK Gene

genes like me logo Genes that share paralogs with ILK: view

Variants for ILK Gene

Sequence variations from dbSNP and Humsavar for ILK Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1043388 Benign 6,608,435(+) GAACA(C/T)GGGAA reference, synonymous-codon, utr-variant-5-prime
rs1043390 Benign 6,609,602(+) ATGCC(A/G)TATGG synonymous-codon, reference
rs1876298 -- 6,606,537(+) CAGTT(C/G)GCCAG intron-variant
rs2048092 -- 6,608,300(+) TGTGT(A/G)CTCTT intron-variant
rs2243625 -- 6,606,759(+) TGGCA(C/G)GCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ILK Gene

Variant ID Type Subtype PubMed ID
nsv825755 CNV Gain 20364138
esv996362 CNV Deletion 20482838
nsv896971 CNV Loss 21882294
nsv896972 CNV Loss 21882294

Relevant External Links for ILK Gene

HapMap Linkage Disequilibrium report
ILK
Human Gene Mutation Database (HGMD)
ILK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ILK Gene

Disorders for ILK Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ILK Gene including...

Search for ILK Gene in MalaCards »

(1) University of Copenhagen DISEASES for ILK Gene

(43) Novoseek inferred disease relationships for ILK Gene

Disease -log(P) Hits PubMed IDs
renal fibrosis 49.7 4
carcinoma non-small cell lung 34.4 1
tumors 32.8 70
cancer 30.9 41
ovarian cancer 29.9 15

Relevant External Links for ILK

Genetic Association Database (GAD)
ILK
Human Genome Epidemiology (HuGE) Navigator
ILK
genes like me logo Genes that share disorders with ILK: view

No data available for UniProtKB/Swiss-Prot for ILK Gene

Publications for ILK Gene

  1. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. (PMID: 9736715) Delcommenne M. … Dedhar S. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  2. Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation. (PMID: 10871859) Janji B. … Kieffer N. (Oncogene 2000) 3 4 23
  3. Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. (PMID: 17646580) KnAPll R. … Bakkers J. (Circulation 2007) 3 4 23
  4. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. (PMID: 8538749) Hannigan G.E. … Dedhar S. (Nature 1996) 2 3 4
  5. Integrin alphavbeta3 upregulates integrin-linked kinase expression in human ovarian cancer cells via enhancement of ILK gene transcription. (PMID: 19334037) LAPssner D. … Reuning U. (J. Cell. Physiol. 2009) 3 23

Products for ILK Gene

  • Addgene plasmids for ILK

Sources for ILK Gene

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