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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ILK Gene

protein-coding   GIFtS: 70
GCID: GC11P006581

Integrin-Linked Kinase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin-Linked Kinase1 2     Integrin-Linked Kinase-22
59 KDa Serine/Threonine-Protein Kinase2 3     Integrin-Linked Protein Kinase2
ILK-12 3     EC 2.7.11.13
ILK-22 3     ILK13
p59ILK2 3     ILK23
P592 5     

External Ids:    HGNC: 60401   Entrez Gene: 36112   Ensembl: ENSG000001663337   OMIM: 6023665   UniProtKB: Q134183   

Export aliases for ILK gene to outside databases

Previous GC identifers: GC11P007367 GC11P007085 GC11P006584 GC11P006590 GC11P006560 GC11P006283


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ILK Gene:
This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein
associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates
integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal
transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Jun 2013)

GeneCards Summary for ILK Gene: 
ILK (integrin-linked kinase) is a protein-coding gene. Diseases associated with ILK include proliferative vitreoretinopathy, and familial adenomatous polyposis, and among its related super-pathways are Focal Adhesion and Signal transduction PTEN pathway. GO annotations related to this gene include protein serine/threonine kinase activity and signal transducer activity. An important paralog of this gene is FPGT-TNNI3K.

UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418
Function: Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator
of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is
considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be
implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in
epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also
AKT1 and GSK3B

Gene Wiki entry for ILK (Integrin-linked kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ILK gene promoter:
         ATF-2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidILK promoter sequence
   Search SABiosciences Chromatin IP Primers for ILK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ILK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

ILK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ILK gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P006581:  view genomic region     (about GC identifiers)

Start:
6,624,961 bp from pter      End:
6,632,102 bp from pter
Size:
7,142 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418 (See protein sequence)
Recommended Name: Integrin-linked protein kinase  
Size: 452 amino acids; 51419 Da
Subunit: Interacts with FERMT2 (By similarity). Interacts with the cytoplasmic domain of ITGB1. Could also
interact with integrin ITGB2, ITGB3 and/or ITGB5. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts
with PARVA and PARVB; these compete for the same binding site. Interacts probably also with TGFB1I1. Interacts
(via ANK repeats) with EPHA1 (via SAM domain); stimulated by EFNA1 but independent of the kinase activity of
EPHA1
Subcellular location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Cell projection, lamellipodium (By similarity). Cytoplasm, myofibril, sarcomere
Sequence caution: Sequence=CAB94832.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Was
originally thought to be distinct gene (ILK2) (PubMed:10871859);
6 PDB 3D structures from and Proteopedia for ILK:
2KBX (3D)        3F6Q (3D)        3IXE (3D)        3KMU (3D)        3KMW (3D)        3REP (3D)    
Secondary accessions: D3DQU0 P57043 Q68DZ3

Explore the universe of human proteins at neXtProt for ILK: NX_Q13418

Explore proteomics data for ILK at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated on serine residues
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13418

  • ILK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ILK Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001014794.1  NP_001014795.1  NP_001265370.1  NP_001265371.1  NP_004508.1  

    ENSEMBL proteins: 
     ENSP00000299421   ENSP00000434492   ENSP00000432796   ENSP00000403487   ENSP00000432617  
     ENSP00000433129   ENSP00000436062   ENSP00000435323   ENSP00000379975   ENSP00000439606  
    Reactome Protein details: Q13418
    Human Recombinant Protein Products for ILK: 
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    OriGene MassSpec for ILK 
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    Novus Biologicals ILK Proteins
    Novus Biologicals ILK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ILK
    Cloud-Clone Corp. Proteins for ILK 

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0005911cell-cell junction IEA--
    GO:0005925focal adhesion IEA--

    ILK for ontologies           About GeneDecksing



    ILK Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ILK
    R&D Systems Antibodies for ILK
    Cell Signaling Technology (CST) Antibodies for ILK 
    OriGene Antibodies for ILK
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    Novus Biologicals ILK Antibodies
    Abcam antibodies for ILK
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    ThermoFisher Antibody for ILK
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    Assay Products for ILK: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ILK
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ILK 
    Cloud-Clone Corp. CLIAs for ILK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: integrin-linked kinase 
    ILK subfamily

    5/6 InterPro protein domains (see all 6):
     IPR016253 Integrin-linked_kinase
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR002110 Ankyrin_rpt
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q13418

    ProtoNet protein and cluster: Q13418

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418
    Domain: A PH-like domain is involved in phosphatidylinositol phosphate binding
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family
    Similarity: Contains 5 ANK repeats
    Similarity: Contains 1 protein kinase domain


    ILK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ILK_HUMAN, Q13418
    Function: Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator
    of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is
    considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be
    implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in
    epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also
    AKT1 and GSK3B
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Stimulated rapidly but transiently by both cell fibronectin interactions, as well as by
    insulin, in a PI3-K-dependent manner, likely via the binding of PtdIns(3,4,5)P3 with a PH-like domain of ILK

         Genatlas biochemistry entry for ILK:
    integrin-linked kinase,59kDa,widely expressed,potential regulator of integrin beta-1 mediated signal
    transduction,overlapping TAF2H by its 3'end (divergently oriented)

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA10871859
    GO:0004713protein tyrosine kinase activity ----
    GO:0004871signal transducer activity IEA--
    GO:0005178integrin binding IEA--
         
    ILK for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for ILK:
     Decreased substrate adherent c  Increased cell death HMECs cel  Increased mitotic index  Increases Tamoxifen sensitivit 
     Synthetic lethal with Ras  Synthetic lethal with paclitax 

         15/19 MGI mutant phenotypes (inferred from 11 alleles(MGI details for Ilk) (see all 19):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  no phenotypic analysis  normal  other 

    ILK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ILK: Ilktm2Ref Ilktm2Star

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ILK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ILK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ILK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ILK 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ILK
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate ILK:
    hsa-miR-2116* hsa-miR-542-3p hsa-miR-624* hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmidILK 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ILK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ILK

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ILK

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ILK (see all 20)
    OriGene ORF clones in mouse, rat for ILK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ILK (NM_004517)
    Sino Biological Human cDNA Clone for ILK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ILK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ILK
    Sirion Biotech Customized lentivirus for stable overexpression of ILK 
                         Customized lentivirus expression plasmids for stable overexpression of ILK 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ILK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ILK About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    2Endometrial cancer
    Endometrial cancer0.45
    Signal transduction PTEN pathway0.45
    3Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    4Cell-cell junction organization
    Cell junction organization0.69
    Cell-Cell communication0.64
    5Cytoskeleton remodeling Reverse signaling by ephrin B
    Cytoskeleton remodeling Reverse signaling by ephrin B0.94

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for ILK
        Cytoskeleton remodeling Integrin outside-in signaling
    Signal transduction PTEN pathway
    Cell adhesion PLAU signaling
    Cytoskeleton remodeling Reverse signaling by ephrin B

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ILK
        Sertoli-Sertoli Cell Junction Dynamics
    ILK Signaling
    Epithelial Tight Junctions
    Akt Signaling
    Germ Cell-Sertoli Cell Junction Dynamics

    1 Cell Signaling Technology (CST) Pathway for ILK
        Adhesion

    5 GeneGo (Thomson Reuters) Pathways for ILK
        Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion PLAU signaling
    Development EGFR signaling pathway
    Cytoskeleton remodeling Reverse signaling by ephrin B
    Signal transduction PTEN pathway

    5 BioSystems Pathways for ILK
        Focal Adhesion
    Integrin-mediated cell adhesion
    Eukaryotic Transcription Initiation
    Integrins in angiogenesis
    Osteopontin-mediated events


    4        Reactome Pathways for ILK
        Localization of the PINCH-ILK-PARVIN complex to focal adhesions
    Cell-extracellular matrix interactions
    Cell junction organization
    Cell-Cell communication


    4         Kegg Pathways  (Kegg details for ILK):
        PPAR signaling pathway
    Focal adhesion
    Bacterial invasion of epithelial cells
    Endometrial cancer


    ILK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ILK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/708 Interacting proteins for ILK (Q134181, 2, 3 ENSP000002994214) via UniProtKB, MINT, STRING, and/or I2D (see all 708)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP8Q147901, 3, ENSP000003512734EBI-747644,EBI-78060 I2D: score=3 STRING: ENSP00000351273
    CASP9P552111, 3, ENSP000003302374EBI-747644,EBI-516799 I2D: score=3 STRING: ENSP00000330237
    CKBP122772, 3, ENSP000002991984MINT-8258588 I2D: score=2 STRING: ENSP00000299198
    COPG1Q9Y6782, 3, ENSP000003250024MINT-7945693 I2D: score=2 STRING: ENSP00000325002
    FANCIQ9NVI12, 3, ENSP000003108424MINT-7945693 I2D: score=2 STRING: ENSP00000310842
    About this table

    Gene Ontology (GO): 5/44 biological process terms (GO ID links to tree view) (see all 44):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth ----
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0001954positive regulation of cell-matrix adhesion IEA--
    GO:0006468protein phosphorylation IDA10871859
    GO:0006469negative regulation of protein kinase activity IEA--

    ILK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ILK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ILK

    2 HMDB Compounds for ILK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    10/26 Novoseek inferred chemical compound relationships for ILK gene (see all 26)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 60.8 28 12778079 (2), 15735038 (2), 15867245 (2), 16648553 (2) (see all 23)
    phosphatidylinositol 58.4 16 16546979 (1), 17107957 (1), 11313365 (1), 16407822 (1) (see all 15)
    threonine 55.9 23 15722199 (2), 11694518 (1), 17656471 (1), 19262169 (1) (see all 22)
    phosphoinositide 51 13 12101188 (4), 17298394 (1), 19920184 (1), 12637511 (1) (see all 9)
    ly294002 50.4 6 15044083 (2), 17234779 (1), 14751515 (1), 16472257 (1)
    serine 43 23 15722199 (2), 11694518 (1), 17656471 (1), 19262169 (1) (see all 22)
    rapamycin 39 14 16014356 (1), 17588951 (1), 20232298 (1), 16397254 (1) (see all 8)
    chlorothalonil 35.6 3 2266108 (1)
    matrigel 33.9 3 12925691 (1), 16818815 (1)
    wortmannin 33 2 15044083 (1), 14751515 (1)

    Search CenterWatch for drugs/clinical trials and news about ILK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ILK gene (5 alternative transcripts): 
    NM_001014794.2  NM_001014795.2  NM_001278441.1  NM_001278442.1  NM_004517.3  

    Unigene Cluster for ILK:

    Integrin-linked kinase
    Hs.706355  [show with all ESTs]
    Unigene Representative Sequence: CR749220
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299421(uc001mee.3 uc001mef.3 uc010raq.2) ENST00000532063
    ENST00000527327 ENST00000420936 ENST00000526114 ENST00000527394 ENST00000527121
    ENST00000528995 ENST00000534565 ENST00000396751(uc001meh.3) ENST00000526318
    ENST00000524735 ENST00000528784 ENST00000534706 ENST00000530016 ENST00000526711
    ENST00000537806(uc010rap.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    SwitchGear 3'UTR luciferase reporter plasmidILK 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ILK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ILK
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ILK

    Additional mRNA sequence: 

    AK293474.1 AK296628.1 AK314843.1 BC001554.1 CR407673.1 CR749220.1 U40282.1 

    24/31 DOTS entries (see all 31):

    DT.92447057  DT.92447059  DT.452885  DT.100038213  DT.100886845  DT.95173144  DT.100886859  DT.95272900 
    DT.97802133  DT.100886848  DT.70101889  DT.95272905  DT.100886863  DT.100886855  DT.120709573  DT.449776 
    DT.100886843  DT.100886846  DT.100886862  DT.120709433  DT.100886860  DT.100886865  DT.100886868  DT.100886870 

    24/522 AceView cDNA sequences (see all 522):

    CA417315 BM997788 AI752154 BQ936739 BG682011 CR608758 BQ222152 BU787906 
    BU177774 AI752153 BU615476 CA306218 BQ773821 CR601713 CR749220 BU500956 
    BQ672915 CD368094 AI807533 BQ084531 BQ774612 AW771698 CB141333 AI348148 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for ILK (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^
    SP1:                                -     -           -                             -                 -                                                         
    SP2:        -     -                 -     -           -                             -                 -                                                         
    SP3:        -                             -           -                             -                 -                                                         
    SP4:        -     -                 -     -           -                                               -                                                         
    SP5:        -                       -     -           -                             -                 -                                                         

    ExUns: 14a · 14b ^ 15
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for ILK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ILK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGGATCA
    ILK Expression
    About this image


    See ILK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ILK

    SOURCE GeneReport for Unigene cluster: Hs.706355

    UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418
    Tissue specificity: Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed
    in placenta, lung and liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including ILK (see all 8): 
              mTOR Signaling in human mouse rat
              Fibrosis in human mouse rat
              Tight Junctions in human mouse rat
              Cell Motility in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ILK gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ilk1 , 5 integrin linked kinase1, 5 91.81(n)1
    99.56(a)1
      7 (55.97 cM)5
    162021  NM_010562.21  NP_034692.21 
     1057365925 
    chicken
    (Gallus gallus)
    Aves ILK1 integrin-linked kinase 80.31(n)
    90.71(a)
      374018  NM_204194.1  NP_989525.1 
    lizard
    (Anolis carolinensis)
    Reptilia ILK6
    Uncharacterized protein
    69(a)
    1 ↔ 1
    GL345104.1(67-10590)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.59782 Xenopus laevis transcribed sequence with moderate similarity more 78.15(n)    BU916167.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658422 hypothetical protein MGC65842 79.11(n)   393543  BC056593.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ilk1 , 3 integrin-mediated signaling pathway
    protein serine/threonine more3
    Integrin linked kinase1
    59(a)3
    60.48(n)1
    60.63(a)1
      78C23
    535731  NM_080262.31  NP_525001.21 
    worm
    (Caenorhabditis elegans)
    Secernentea pat-41 , 3 integrin-linked kinase3
    Protein PAT-41
    58(a)3
    57.85(n)1
    58.97(a)1
      III(89525-91902)3
    1751751  NM_064738.41  NP_497139.11 


    ENSEMBL Gene Tree for ILK (if available)
    TreeFam Gene Tree for ILK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ILK gene
    FPGT-TNNI3K2  ARAF2  MAP3K122  MAP3K112  KIAA18042  RAF12  KSR22  MAP3K72  
    TNNI3K2  KSR12  ZAK2  MOS2  MAP3K132  BRAF2  MAP3K92  MAP3K102  
    10 SIMAP similar genes for ILK using alignment to 7 protein entries:     ILK_HUMAN (see all proteins):
    PLA2G6    ANKRD42    ANKRD44    ANKRD54    HACE1    RAI14
    GABPB1    IkBa    ANKRD65    tec

    ILK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/319 SNPs in ILK are shown (see all 319)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs110409341,2
    C,F,H--6537283(+) CTGGGC/GTGAAT 2 -- us2k110Minor allele frequency- G:0.03NS EA NA WA 5006
    rs2001722761,2
    --6537335(+) TCTTCA/GGCAGA 2 -- us2k10--------
    rs2014542601,2
    --6537398(+) TCCTCA/GGAGTC 3 -- us2k10--------
    rs773253061,2
    C--6537449(+) TTCTTC/TCCTAC 3 -- us2k10--------
    rs1443257981,2
    C,F--6537487(+) CTTTTT/GGGGGC 3 -- us2k11Minor allele frequency- G:0.00NA 4550
    rs2000967441,2
    C--6537492(+) TGGGGA/CATTTC 3 -- us2k10--------
    rs1904618451,2
    C--6537543(+) ATAGGC/GTGGGG 3 -- us2k10--------
    rs2019514451,2
    C--6537547(+) GCTGGA/GGGGAT 3 -- us2k10--------
    rs2021466581,2
    --6537581(+) AGGGCC/TCGTAA 3 -- us2k10--------
    rs1825586561,2
    C--6537583(+) GGCCCC/GTAATG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ILK (6624961 - 6632102 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ILK:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv996362CNV Deletion20482838
    nsv896972CNV Loss21882294
    nsv896971CNV Loss21882294
    nsv825755CNV Gain20364138


    Human Gene Mutation Database (HGMD): ILK
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ILK
    DNA2.0 Custom Variant and Variant Library Synthesis for ILK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602366    OMIM disorders: --

    20/58 diseases for ILK (see all 58):    About MalaCards
    proliferative vitreoretinopathy    familial adenomatous polyposis    ataxia telangiectasia    stomach cancer
    laryngeal carcinoma    focal segmental glomerulosclerosis    dilated cardiomyopathy    laryngitis
    laryngeal squamous cell carcinoma    squamous cell carcinoma of the head and neck    purpura    glioblastoma
    prostate adenocarcinoma    ataxia    basal cell carcinoma    colon cancer
    liver cirrhosis    thyroid cancer    rhabdomyosarcoma    pulmonary fibrosis

    1 disease from the University of Copenhagen DISEASES database for ILK:
    Cancer

    ILK for disorders           About GeneDecksing

    10/43 Novoseek inferred disease relationships for ILK gene (see all 43)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal fibrosis 49.7 4 12925691 (2), 17498677 (2)
    carcinoma non-small cell lung 34.4 1 19176380 (1)
    tumors 32.8 94 17224516 (5), 19923885 (5), 12596061 (4), 15631637 (3) (see all 39)
    cancer 30.9 55 19895269 (3), 17143519 (3), 18505933 (3), 19409087 (2) (see all 27)
    ovarian cancer 29.9 20 14517840 (4), 17187779 (3), 12642872 (2), 19334037 (2) (see all 8)
    metastasis 29.4 18 12596061 (3), 16836071 (3), 15300800 (2), 15631637 (1) (see all 9)
    familial adenomatous polyposis 28.9 2 16799642 (1), 12771992 (1)
    thyroid carcinoma anaplastic 28.4 6 16093430 (5)
    prostate carcinoma 27.8 4 14990992 (1), 9681506 (1), 10716737 (1)
    prostate cancer 25.4 12 15704679 (4), 15870868 (1), 15782140 (1), 10716737 (1) (see all 6)

    Genetic Association Database (GAD): ILK
    Human Genome Epidemiology (HuGE) Navigator: ILK (1 document)

    Export disorders for ILK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ILK gene, integrated from 9 sources (see all 363):
    (articles sorted by number of sources associating them with ILK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. (PubMed id 8538749)1, 2, 3 Hannigan G.E.... Dedhar S. (1996)
    2. Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation. (PubMed id 10871859)1, 2, 9 Janji B.... Kieffer N. (2000)
    3. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. (PubMed id 9736715)1, 2, 9 Delcommenne M.... Dedhar S. (1998)
    4. Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. (PubMed id 19117955)1, 2, 9 Yang Y.... Qin J. (2009)
    5. The pseudoactive site of ILK is essential for its bin ding to alpha-Parvin and localization to focal adhesions. (PubMed id 20005845)1, 2, 9 Fukuda K....Qin J. (2009)
    6. Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. (PubMed id 15284246)1, 2, 9 Zhang Y....Wu C. (2004)
    7. A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. (PubMed id 11402068)1, 2, 9 Yamaji S.... Ishigatsubo Y. (2001)
    8. The structural basis of integrin-linked kinase-PINCH interactions. (PubMed id 19074270)1, 2, 9 Chiswell B.P.... Calderwood D.A. (2008)
    9. EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. (PubMed id 19118217)1, 2, 9 Yamazaki T....Maru Y. (2009)
    10. Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration. (PubMed id 12167643)1, 2, 9 Zhang Y.... Wu C. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3611 HGNC: 6040 AceView: ILK Ensembl:ENSG00000166333 euGenes: HUgn3611
    ECgene: ILK Kegg: 3611 H-InvDB: ILK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ILK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ILK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ILK gene:
    Search GeneIP for patents involving ILK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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