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Aliases for ILK Gene

Aliases for ILK Gene

  • Integrin Linked Kinase 2 3 5
  • 59 KDa Serine/Threonine-Protein Kinase 3 4
  • Integrin-Linked Kinase 2 3
  • P59ILK 3 4
  • ILK-1 3 4
  • ILK-2 3 4
  • Epididymis Secretory Protein Li 28 3
  • Integrin-Linked Kinase-2 3
  • EC 2.7.11.1 4
  • HEL-S-28 3
  • ILK1 4
  • ILK2 4
  • P59 3

External Ids for ILK Gene

Previous GeneCards Identifiers for ILK Gene

  • GC11P007367
  • GC11P007085
  • GC11P006584
  • GC11P006590
  • GC11P006560
  • GC11P006283

Summaries for ILK Gene

Entrez Gene Summary for ILK Gene

  • This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for ILK Gene

ILK (Integrin Linked Kinase) is a Protein Coding gene. Diseases associated with ILK include scar contracture and lung cancer. Among its related pathways are Axon guidance and Bacterial invasion of epithelial cells. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TNNI3K.

UniProtKB/Swiss-Prot for ILK Gene

  • Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

Gene Wiki entry for ILK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ILK Gene

Genomics for ILK Gene

Regulatory Elements for ILK Gene

Enhancers for ILK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ILK on UCSC Golden Path with GeneCards custom track

Promoters for ILK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ILK on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ILK gene promoter:

Genomic Location for ILK Gene

Chromosome:
11
Start:
6,603,708 bp from pter
End:
6,610,874 bp from pter
Size:
7,167 bases
Orientation:
Plus strand

Genomic View for ILK Gene

Genes around ILK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ILK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ILK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ILK Gene

Proteins for ILK Gene

  • Protein details for ILK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13418-ILK_HUMAN
    Recommended name:
    Integrin-linked protein kinase
    Protein Accession:
    Q13418
    Secondary Accessions:
    • B7Z1I0
    • B7Z418
    • D3DQU0
    • P57043
    • Q68DZ3

    Protein attributes for ILK Gene

    Size:
    452 amino acids
    Molecular mass:
    51419 Da
    Quaternary structure:
    • Interacts with FERMT2 (By similarity). Interacts with the cytoplasmic domain of ITGB1. Could also interact with integrin ITGB2, ITGB3 and/or ITGB5. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts with PARVA and PARVB; these compete for the same binding site. Interacts probably also with TGFB1I1. Interacts (via ANK repeats) with EPHA1 (via SAM domain); stimulated by EFNA1 but independent of the kinase activity of EPHA1.
    SequenceCaution:
    • Sequence=CAB94832.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Was originally thought to be distinct gene (ILK2) (PubMed:10871859).; Evidence={ECO:0000305 PubMed:10871859};

    Three dimensional structures from OCA and Proteopedia for ILK Gene

    Alternative splice isoforms for ILK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ILK Gene

Proteomics data for ILK Gene at MOPED

Post-translational modifications for ILK Gene

  • Autophosphorylated on serine residues.
  • Ubiquitination at Lys 85, Lys 165, and Lys 191
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ILK (ILK)

No data available for DME Specific Peptides for ILK Gene

Domains & Families for ILK Gene

Gene Families for ILK Gene

Graphical View of Domain Structure for InterPro Entry

Q13418

UniProtKB/Swiss-Prot:

ILK_HUMAN :
  • A PH-like domain is involved in phosphatidylinositol phosphate binding.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
  • Contains 5 ANK repeats.
Domain:
  • A PH-like domain is involved in phosphatidylinositol phosphate binding.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with ILK: view

Function for ILK Gene

Molecular function for ILK Gene

GENATLAS Biochemistry:
integrin-linked kinase,59kDa,widely expressed,potential regulator of integrin beta-1 mediated signal transduction,overlapping TAF2H by its 3end (divergently oriented)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated rapidly but transiently by both cell fibronectin interactions, as well as by insulin, in a PI3-K-dependent manner, likely via the binding of PtdIns(3,4,5)P3 with a PH-like domain of ILK.
UniProtKB/Swiss-Prot Function:
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

Enzyme Numbers (IUBMB) for ILK Gene

Gene Ontology (GO) - Molecular Function for ILK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IEA --
genes like me logo Genes that share ontologies with ILK: view
genes like me logo Genes that share phenotypes with ILK: view

Animal Models for ILK Gene

MGI Knock Outs for ILK:

Animal Model Products

  • Taconic Biosciences Mouse Models for ILK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ILK Gene

Localization for ILK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ILK Gene

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ILK Gene COMPARTMENTS Subcellular localization image for ILK gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
cytoskeleton 4
extracellular 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ILK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030424 axon IEA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with ILK: view

Pathways & Interactions for ILK Gene

genes like me logo Genes that share pathways with ILK: view

SIGNOR curated interactions for ILK Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for ILK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003151 outflow tract morphogenesis IEA --
GO:0006468 protein phosphorylation IEA,IDA 10871859
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0007050 cell cycle arrest IEA --
GO:0007160 cell-matrix adhesion TAS 8538749
genes like me logo Genes that share ontologies with ILK: view

Drugs & Compounds for ILK Gene

(12) Drugs for ILK Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(16) Additional Compounds for ILK Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ILK: view

Transcripts for ILK Gene

Unigene Clusters for ILK Gene

Integrin-linked kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ILK Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - -
SP9: - - - -
SP10: - - - -
SP11: - - - -
SP12: -
SP13:
SP14: - - - - - -
SP15: -
SP16:

ExUns: 14a · 14b ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for ILK Gene

GeneLoc Exon Structure for
ILK
ECgene alternative splicing isoforms for
ILK

Expression for ILK Gene

mRNA expression in normal human tissues for ILK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ILK Gene

This gene is overexpressed in Platelet (15.1), Peripheral blood mononuclear cells (7.2), and Prostate (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ILK Gene



SOURCE GeneReport for Unigene cluster for ILK Gene Hs.706355

mRNA Expression by UniProt/SwissProt for ILK Gene

Q13418-ILK_HUMAN
Tissue specificity: Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
genes like me logo Genes that share expression patterns with ILK: view

Protein tissue co-expression partners for ILK Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ILK Gene

Orthologs for ILK Gene

This gene was present in the common ancestor of animals.

Orthologs for ILK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ILK 36
  • 100 (a)
OneToOne
ILK 35
  • 99.56 (n)
  • 100 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 3 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ilk 36
  • 100 (a)
OneToOne
Ilk 16
Ilk 35
  • 91.81 (n)
  • 99.56 (a)
oppossum
(Monodelphis domestica)
Mammalia ILK 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ILK 36
  • 100 (a)
OneToOne
ILK 35
  • 93.66 (n)
  • 99.78 (a)
cow
(Bos Taurus)
Mammalia ILK 36
  • 99 (a)
OneToOne
ILK 35
  • 94.03 (n)
  • 99.34 (a)
rat
(Rattus norvegicus)
Mammalia Ilk 35
  • 91.37 (n)
  • 99.56 (a)
chicken
(Gallus gallus)
Aves ILK 36
  • 90 (a)
OneToOne
ILK 35
  • 80.31 (n)
  • 90.71 (a)
lizard
(Anolis carolinensis)
Reptilia ILK 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5978 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1347 35
ilk 35
  • 76.77 (n)
  • 88.5 (a)
zebrafish
(Danio rerio)
Actinopterygii ilk 36
  • 87 (a)
OneToOne
zgc65842 35
ilk 35
  • 77.29 (n)
  • 86.73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.222 35
fruit fly
(Drosophila melanogaster)
Insecta Ilk 36
  • 60 (a)
OneToOne
Ilk 35
  • 60.48 (n)
  • 60.63 (a)
Ilk 37
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006573 35
  • 60.33 (n)
  • 60.18 (a)
worm
(Caenorhabditis elegans)
Secernentea pat-4 36
  • 56 (a)
OneToOne
pat-4 35
  • 57.85 (n)
  • 58.97 (a)
pat-4 37
  • 58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11308 35
Species with no ortholog for ILK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ILK Gene

ENSEMBL:
Gene Tree for ILK (if available)
TreeFam:
Gene Tree for ILK (if available)

Paralogs for ILK Gene

Paralogs for ILK Gene

genes like me logo Genes that share paralogs with ILK: view

Variants for ILK Gene

Sequence variations from dbSNP and Humsavar for ILK Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_069753 -
rs1043388 -- 6,608,435(+) GAACA(C/T)GGGAA reference, synonymous-codon, utr-variant-5-prime
rs1043390 -- 6,609,602(+) ATGCC(A/G)TATGG reference, synonymous-codon
rs1876298 -- 6,606,537(-) AGTTG(C/G)CCAGT intron-variant
rs2048092 -- 6,608,300(+) TGTGT(A/G)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ILK Gene

Variant ID Type Subtype PubMed ID
nsv825755 CNV Gain 20364138
esv996362 CNV Deletion 20482838
nsv896971 CNV Loss 21882294
nsv896972 CNV Loss 21882294

Variation tolerance for ILK Gene

Residual Variation Intolerance Score: 27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ILK Gene

HapMap Linkage Disequilibrium report
ILK
Human Gene Mutation Database (HGMD)
ILK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ILK Gene

Disorders for ILK Gene

MalaCards: The human disease database

(3) MalaCards diseases for ILK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
scar contracture
lung cancer
  • lung cancer, protection against
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search ILK in MalaCards View complete list of genes associated with diseases

Relevant External Links for ILK

Genetic Association Database (GAD)
ILK
Human Genome Epidemiology (HuGE) Navigator
ILK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ILK
genes like me logo Genes that share disorders with ILK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ILK Gene

Publications for ILK Gene

  1. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. (PMID: 8538749) Hannigan G.E. … Dedhar S. (Nature 1996) 2 3 4 67
  2. Tumor expression of integrin-linked kinase (ILK) correlates with the expression of the E-cadherin repressor snail: an immunohistochemical study in ductal pancreatic adenocarcinoma. (PMID: 20091050) Schaeffer D.F. … Owen D.A. (Virchows Arch. 2010) 3 23
  3. Hypoxia induces BMP-2 expression via ILK, Akt, mTOR, and HIF-1 pathways in osteoblasts. (PMID: 20232298) Tseng W.P. … Tang C.H. (J. Cell. Physiol. 2010) 3 23
  4. Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells. (PMID: 19118218) Bergmann S. … Hammerschmidt S. (J. Cell. Sci. 2009) 3 23
  5. Fish oil inhibits human lung carcinoma cell growth by suppressing integrin-linked kinase. (PMID: 19147542) Han S. … Roman J. (Mol. Cancer Res. 2009) 3 23

Products for ILK Gene

Sources for ILK Gene

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