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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ILF3 Gene

protein-coding   GIFtS: 58
GCID: GC19P010764

Interleukin Enhancer Binding Factor 3, 90kDa

(Previous names: interleukin enhancer binding factor 3, 90kD)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin Enhancer Binding Factor 3, 90kDa1 2     CBTF2
M-Phase Phosphoprotein 41 2 3     MMP42
DRBP762 3 5     NF1102
MPHOSPH42 3 5     NF110b2
NF902 3 5     NF90a2
NFAR2 3 5     NF90b2
Nuclear Factor Associated With DsRNA2 3     NFAR-12
Nuclear Factor Of Activated T-Cells 90 KDa2 3     NFAR22
Translational Control Protein 802 3     TCP1102
DRBF2 3     Double-Stranded RNA-Binding Protein, 76 KD2
MPP42 3     DsRNA Binding Protein NFAR-2/MPP42
NF-AT-902 3     Interleukin Enhancer-Binding Factor 32
TCP802 3     Nuclear Factor Of Activated T-Cells, 90 KD2
Interleukin Enhancer Binding Factor 3, 90kD1     Double-Stranded RNA-Binding Protein 763

External Ids:    HGNC: 60381   Entrez Gene: 36092   Ensembl: ENSG000001293517   OMIM: 6031825   UniProtKB: Q129063   

Export aliases for ILF3 gene to outside databases

Previous GC identifers: GC19P010895 GC19P010987 GC19P010610 GC19P010625 GC19P010342


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ILF3 Gene:
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small
noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to
be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell
expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the
product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the
cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization.
In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor
effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants
encoding distinct isoforms.(provided by RefSeq, Nov 2008)

GeneCards Summary for ILF3 Gene: 
ILF3 (interleukin enhancer binding factor 3, 90kDa) is a protein-coding gene. Diseases associated with ILF3 include ovarian epithelial cancer, and nasopharyngitis. GO annotations related to this gene include double-stranded RNA binding and RNA binding. An important paralog of this gene is ZFR2.

UniProtKB/Swiss-Prot: ILF3_HUMAN, Q12906
Function: May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act
as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other
mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to
polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2
gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme
complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit
vesicular stomatitis virus (VSV) replication (By similarity)

Gene Wiki entry for ILF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ILF3 gene promoter:
         HEN1   TBP   USF1   USF-1   USF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidILF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ILF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ILF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ILF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ILF3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010764:  view genomic region     (about GC identifiers)

Start:
10,764,937 bp from pter      End:
10,803,095 bp from pter
Size:
38,159 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ILF3_HUMAN, Q12906 (See protein sequence)
Recommended Name: Interleukin enhancer-binding factor 3  
Size: 894 amino acids; 95338 Da
Subunit: Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1,
PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least composed of ACTB,
ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3,
NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated
mRNAs. Interacts with FUS and SMN proteins and with PRMT1. Forms a complex with ILF2. Can also bind to
PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of XRCC6/KU70 and
XRCC5/KU80. Forms a heteromeric complex with ZNF346 and ILF3. Found in a nuclear export complex with XPO5, ILF3,
Ran and double-stranded RNA or double-stranded minihelix VA1 RNA. Found in a nuclear export complex with XPO5,
RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5 and ZNF346. Forms a complex with ILF2, YLPM1,
KHDRBS1, RBMX, NCOA5 and PPP1CA. Interacts with AGO1 and AGO2
Subcellular location: Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral
dsRNA. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315
causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3.
Localized in cytoplasmic mRNP granules containing untranslated mRNAs
Sequence caution: Sequence=AAA20994.1; Type=Miscellaneous discrepancy; Note=Sequencing errors;
Sequence=AAH48314.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
2 PDB 3D structures from and Proteopedia for ILF3:
2L33 (3D)        3P1X (3D)    
Secondary accessions: A8K6F2 G5E9M5 O43409 Q6P1X1 Q86XY7 Q99544 Q99545 Q9BZH4 Q9BZH5 Q9NQ95
Q9NQ96 Q9NQ97 Q9NQ98 Q9NQ99 Q9NQA0 Q9NQA1 Q9NQA2 Q9NRN2 Q9NRN3 Q9NRN4 Q9UMZ9 Q9UN00 Q9UN84
Q9UNA2
Alternative splicing: 7 isoforms:  Q12906-1   Q12906-2   Q12906-3   Q12906-4   Q12906-5   Q12906-6   Q12906-7   (Gene prediction based on EST data. Contains a phosphoserine at position 482)

Explore the universe of human proteins at neXtProt for ILF3: NX_Q12906

Explore proteomics data for ILF3 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Thr-188 and Thr-315 by PKR in response to certain RNA viruses. This phosphorylation results in
    the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can
    bind to viral RNAs and impede viral replication
  • UniProtKB: Methylated by protein arginine N-methyltransferase 1
  • UniProtKB: Arg-609 is dimethylated, probably to asymmetric dimethylarginine
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12906

  • ILF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ILF3 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001131145.1  NP_004507.2  NP_036350.2  NP_060090.2  NP_703194.1  

    ENSEMBL proteins: 
     ENSP00000384660   ENSP00000465219   ENSP00000468134   ENSP00000466396   ENSP00000465654  
     ENSP00000468323   ENSP00000466991   ENSP00000468092   ENSP00000250241   ENSP00000465515  
     ENSP00000468181   ENSP00000468156   ENSP00000464974   ENSP00000467704   ENSP00000465831  
     ENSP00000467950   ENSP00000467372   ENSP00000466724   ENSP00000466235   ENSP00000404121  
     ENSP00000315205   ENSP00000405436  

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    Cloud-Clone Corp. Proteins for ILF3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10400669
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0030529ribonucleoprotein complex IDA17289661

    ILF3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for ILF3 
    Cloud-Clone Corp. CLIAs for ILF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001159 Ds-RNA-bd
     IPR014720 dsRNA-bd-like_dom
     IPR006561 DZF

    Graphical View of Domain Structure for InterPro Entry Q12906

    ProtoNet protein and cluster: Q12906

    1 Blocks protein domain: IPB001159 Double-stranded RNA binding (DsRBD) domain

    UniProtKB/Swiss-Prot: ILF3_HUMAN, Q12906
    Similarity: Contains 2 DRBM (double-stranded RNA-binding) domains
    Similarity: Contains 1 DZF domain


    ILF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ILF3_HUMAN, Q12906
    Function: May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act
    as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other
    mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to
    polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2
    gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme
    complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit
    vesicular stomatitis virus (VSV) replication (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA10574923
    GO:0003723RNA binding NAS10400669
    GO:0003725double-stranded RNA binding IDA10574923
    GO:0005515protein binding IPI10574923
         
    ILF3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ILF3:
     Increased G1 DNA content 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ilf3):
     behavior/neurological  cellular  growth/size  homeostasis/metabolism  immune system 
     mortality/aging  muscle  respiratory system 

    ILF3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ilf3tm1Pnk for ILF3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ILF3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ILF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ILF3 
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    miRNA
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    hsa-miR-548j hsa-miR-3130-5p hsa-miR-607 hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-1260b hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidILF3 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of ILF3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ILF3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ILF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/768 Interacting proteins for ILF3 (Q129061, 2, 3 ENSP000004041214) via UniProtKB, MINT, STRING, and/or I2D (see all 768)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ILF2Q129052, 3, ENSP000003550114MINT-8076150 MINT-8076195 MINT-6488791 MINT-7945693 MINT-8076167 MINT-8076181 MINT-8076347 MINT-8076071 MINT-8076236 I2D: score=2 STRING: ENSP00000355011
    PRKDCP785272, 3, ENSP000003134204MINT-7945693 MINT-8076071 MINT-8076347 MINT-8076236 I2D: score=1 STRING: ENSP00000313420
    DHX9Q082112, 3, ENSP000003565204MINT-6488791 MINT-7945693 I2D: score=2 STRING: ENSP00000356520
    SMN2Q166372, 3, ENSP000003701194MINT-7945693 I2D: score=1 STRING: ENSP00000370119
    GDF9O603832, 3, ENSP000002968754MINT-64088 I2D: score=4 STRING: ENSP00000296875
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000279M phase NAS8885239
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006468protein phosphorylation IDA--
    GO:0017148negative regulation of translation ISS--
    GO:0045071negative regulation of viral genome replication ISS--

    ILF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ILF3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    3 Novoseek inferred chemical compound relationships for ILF3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nf 45 98.9 54 18458058 (5), 17942973 (5), 9442054 (4), 9843854 (4) (see all 16)
    tacrolimus 28.7 2 7519613 (2)
    cyclosporin a 20.6 3 7519613 (2), 9843854 (1)

    Search CenterWatch for drugs/clinical trials and news about ILF3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ILF3 gene (5 alternative transcripts): 
    NM_001137673.1  NM_004516.3  NM_012218.3  NM_017620.2  NM_153464.2  

    Unigene Cluster for ILF3:

    Interleukin enhancer binding factor 3, 90kDa
    Hs.465885  [show with all ESTs]
    Unigene Representative Sequence: NM_017620
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000587928 ENST00000407004(uc002mpm.2 uc002mpp.3) ENST00000589998
    ENST00000589600 ENST00000589283 ENST00000590009 ENST00000593199 ENST00000587505
    ENST00000589052 ENST00000250241(uc002mpl.2) ENST00000592763 ENST00000588657
    ENST00000590261 ENST00000587941 ENST00000587840 ENST00000589416 ENST00000585835
    ENST00000589485
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF007140.1 AF141870.1 AF167569.1 AF167570.1 AJ271744.1 AJ271745.1 AJ271746.1 AK000018.1 
    AK023222.1 AK025821.1 AK291205.1 AK291617.1 AK293170.1 AK294084.1 AL832528.1 AY240961.1 
    BC001770.1 BC003086.1 BC014221.2 BC018633.2 BC048314.1 BC064836.1 CR457223.1 HQ322263.1 
    HQ322264.1 HQ322265.1 U10324.1 X98264.1 X98265.1 

    24/44 DOTS entries (see all 44):

    DT.443764  DT.95326855  DT.100737828  DT.100051454  DT.100737762  DT.99926713  DT.100737905  DT.99926723 
    DT.95170613  DT.95343275  DT.100737833  DT.92463377  DT.92463379  DT.121436290  DT.95349861  DT.97860656 
    DT.100833554  DT.121436280  DT.121436330  DT.95170610  DT.95170618  DT.97819449  DT.100876567  DT.91896863 

    24/1019 AceView cDNA sequences (see all 1019):

    AU123620 AA355922 CA438132 BG032528 AI167806 BM558708 AW503711 AI262646 
    CA428486 AW057986 BQ920264 AL046775 BU161311 BU162985 AW474524 BG683218 
    F10457 BF356364 BU628884 AI568428 CA393750 CR614313 BQ015641 CB216582 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ILF3 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
    SP1:                    -     -                                                                       -                                         -               
    SP2:                    -     -                                                                                                                 -               
    SP3:                                                                                                  -                                         -     -         
    SP4:                                                                                                  -                                         -     -         
    SP5:                                                                                                                                            -     -         

    ExUns: 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b
    SP1:                          -     -                                 
    SP2:                                -                                 
    SP3:                          -     -                                 
    SP4:                                                                  
    SP5:                          -     -                                 


    ECgene alternative splicing isoforms for ILF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ILF3 expression in normal human tissues (normalized intensities)      ILF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAAGTAAC
    ILF3 Expression
    About this image


    ILF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             ovary ; follicle cells   
             oocyte   

    See ILF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ILF3

    SOURCE GeneReport for Unigene cluster: Hs.465885

    UniProtKB/Swiss-Prot: ILF3_HUMAN, Q12906
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ILF3 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ilf31 , 5 interleukin enhancer binding factor 31, 5 87.12(n)1
    93.51(a)1
      9 (7.78 cM)5
    162011  NM_010561.21  NP_034691.21 
     213680195 
    chicken
    (Gallus gallus)
    Aves --
    --
    87(a)
    possible ortholog
    AADN03020792.1(1609-4417)
    lizard
    (Anolis carolinensis)
    Reptilia ILF36
    interleukin enhancer binding factor 3, 90kDa
    87(a)
    1 ↔ 1
    2(80587883-80620246)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.36472 Xenopus laevis dsRNA-binding protein 4F.1 mRNA, complete more 76.61(n)    AY008299.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.200532 Danio rerio, clone IMAGE3815279, mRNA, partial cds 77.83(n)    BC047175.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Zn72D6
    Zinc-finger protein at 72D
    18(a)
    1 → many
    3L(16099694-16105726)
    worm
    (Caenorhabditis elegans)
    Secernentea Y95B8A.86
    Protein Y95B8A.8
    13(a)
    1 → many
    I(853451-871947)


    ENSEMBL Gene Tree for ILF3 (if available)
    TreeFam Gene Tree for ILF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ILF3 gene
    ZFR22  ILF22  STRBP2  ZFR2  
    3 SIMAP similar genes for ILF3 using alignment to 15 protein entries:     ILF3_HUMAN (see all proteins):
    STRBP    DKFZp434P151    ZFR

    ILF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1036 SNPs in ILF3 are shown (see all 1036)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1142068061,2
    C,F--10700033(+) AAAACT/GTGTTC 5 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1915631721,2
    --10700066(+) CCCCTA/GCCACA 5 -- us2k10--------
    rs1181021701,2
    C,F--10700074(+) ACATAA/CTCACA 5 -- us2k11Minor allele frequency- C:0.04EA 120
    rs1399823681,2
    --10700493(+) TTGGCC/TAGGCT 5 -- us2k10--------
    rs621300371,2
    C--10700560(+) GATTAC/G/TAAGCG 5 -- us2k11NA 2
    rs1179825951,2
    F--10700607(+) CACCTC/GCTTGC 5 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1841390661,2
    --10700757(+) CATGTA/GCCACC 5 -- us2k10--------
    rs1447769591,2
    --10700787(+) TTGTAA/TTTTTA 5 -- us2k10--------
    rs767163591,2
    C--10700824(+) CCAGGC/GTGGTC 5 -- us2k10--------
    rs1466954981,2
    C--10700854(+) ATCCGC/TCCGCC 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for ILF3 (10764937 - 10803095 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ILF3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1002882CNV Deletion20482838
    nsv911047CNV Loss21882294
    nsv833746CNV Loss17160897
    nsv911048CNV Loss21882294
    nsv833745CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603182    OMIM disorders: --

    15 diseases for ILF3:    About MalaCards
    ovarian epithelial cancer    nasopharyngitis    kidney disease    influenza
    myocardial infarction    hepatitis    hepatitis c    hypertension
    hepatitis b    ovarian cancer    lung cancer    prostate cancer
    prostatitis    endotheliitis    breast cancer


    ILF3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ILF3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 16322899 (1), 19088038 (1)

    Genetic Association Database (GAD): ILF3
    Human Genome Epidemiology (HuGE) Navigator: ILF3 (4 documents)

    Export disorders for ILF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ILF3 gene, integrated from 9 sources (see all 157):
    (articles sorted by number of sources associating them with ILF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. (PubMed id 7519613)1, 2, 3, 9 Kao P.N.... Corthesy B. (1994)
    2. Identification of novel M phase phosphoproteins by expression cloning. (PubMed id 8885239)1, 2, 3 Matsumoto-Taniura N....Westendorf J.M. (1996)
    3. Molecular cloning and characterization of a translational inhibitory protein that binds to coding sequences of human acid beta-glucosidase and other mRNAs. (PubMed id 10607473)1, 2, 9 Xu Y.-H. and Grabowski G.A. (1999)
    4. Alternative splicing in the human interleukin enhancer binding factor 3 (ILF3) gene. (PubMed id 11167023)1, 2, 9 Duchange N.... Sauvaget D. (2000)
    5. DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. (PubMed id 9442054)1, 2, 9 Ting N.S.Y.... Lees-Miller S.P. (1998)
    6. Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3. (PubMed id 14570900)1, 2, 9 Gwizdek C....Dargemont C. (2004)
    7. The 90- and 110-kDa human NFAR proteins are translated from two differentially spliced mRNAs encoded on chromosome 19p13. (PubMed id 11161820)1, 2, 9 Saunders L.R.... Barber G.N. (2001)
    8. Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR. (PubMed id 11438536)1, 2, 9 Saunders L.R.... Barber G.N. (2001)
    9. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin- 5. (PubMed id 15254228)1, 2, 9 Chen T.... Macara I.G. (2004)
    10. Exportin-5, a novel karyopherin, mediates nuclear export of double- stranded RNA binding proteins. (PubMed id 11777942)1, 2, 9 Brownawell A.M. and Macara I.G. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3609 HGNC: 6038 AceView: ILF3 Ensembl:ENSG00000129351 euGenes: HUgn3609
    ECgene: ILF3 H-InvDB: ILF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ILF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ILF3 gene:
    Search GeneIP for patents involving ILF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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