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Aliases for ILF3 Gene

Aliases for ILF3 Gene

  • Interleukin Enhancer Binding Factor 3, 90kDa 2 3
  • M-Phase Phosphoprotein 4 2 3 4
  • MPHOSPH4 3 4 6
  • DRBP76 3 4 6
  • NF90 3 4 6
  • NFAR 3 4 6
  • Interleukin Enhancer Binding Factor 3, 90kD 2 3
  • Nuclear Factor Of Activated T-Cells 90 KDa 3 4
  • Nuclear Factor Associated With DsRNA 3 4
  • Translational Control Protein 80 3 4
  • NF-AT-90 3 4
  • TCP80 3 4
  • DRBF 3 4
  • MPP4 3 4
  • Double-Stranded RNA-Binding Protein, 76 KD 3
  • Nuclear Factor Of Activated T-Cells, 90 KD 3
  • Double-Stranded RNA-Binding Protein 76 4
  • Interleukin Enhancer-Binding Factor 3 3
  • DsRNA Binding Protein NFAR-2/MPP4 3
  • NF110b 3
  • NFAR-1 3
  • TCP110 3
  • NF110 3
  • NF90a 3
  • NF90b 3
  • NFAR2 3
  • CBTF 3
  • MMP4 3

External Ids for ILF3 Gene

Previous GeneCards Identifiers for ILF3 Gene

  • GC19P010895
  • GC19P010987
  • GC19P010610
  • GC19P010764
  • GC19P010342

Summaries for ILF3 Gene

Entrez Gene Summary for ILF3 Gene

  • This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]

GeneCards Summary for ILF3 Gene

ILF3 (Interleukin Enhancer Binding Factor 3, 90kDa) is a Protein Coding gene. GO annotations related to this gene include RNA binding and double-stranded RNA binding. An important paralog of this gene is ZFR2.

UniProtKB/Swiss-Prot for ILF3 Gene

  • May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).

Gene Wiki entry for ILF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ILF3 Gene

Genomics for ILF3 Gene

Regulatory Elements for ILF3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ILF3 Gene

Start:
10,654,261 bp from pter
End:
10,692,419 bp from pter
Size:
38,159 bases
Orientation:
Plus strand

Genomic View for ILF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ILF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ILF3 Gene

Proteins for ILF3 Gene

  • Protein details for ILF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12906-ILF3_HUMAN
    Recommended name:
    Interleukin enhancer-binding factor 3
    Protein Accession:
    Q12906
    Secondary Accessions:
    • A8K6F2
    • G5E9M5
    • O43409
    • Q6P1X1
    • Q86XY7
    • Q99544
    • Q99545
    • Q9BZH4
    • Q9BZH5
    • Q9NQ95
    • Q9NQ96
    • Q9NQ97
    • Q9NQ98
    • Q9NQ99
    • Q9NQA0
    • Q9NQA1
    • Q9NQA2
    • Q9NRN2
    • Q9NRN3
    • Q9NRN4
    • Q9UMZ9
    • Q9UN00
    • Q9UN84
    • Q9UNA2

    Protein attributes for ILF3 Gene

    Size:
    894 amino acids
    Molecular mass:
    95338 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with FUS and SMN proteins and with PRMT1. Forms a complex with ILF2. Can also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of XRCC6/KU70 and XRCC5/KU80. Forms a heteromeric complex with ZNF346 and ILF3. Found in a nuclear export complex with XPO5, ILF3, Ran and double-stranded RNA or double-stranded minihelix VA1 RNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5 and ZNF346. Forms a complex with ILF2, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Interacts with AGO1 and AGO2.
    SequenceCaution:
    • Sequence=AAA20994.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAH48314.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ILF3 Gene

    Alternative splice isoforms for ILF3 Gene

neXtProt entry for ILF3 Gene

Proteomics data for ILF3 Gene at MOPED

Post-translational modifications for ILF3 Gene

  • Arg-609 is dimethylated, probably to asymmetric dimethylarginine
  • Methylated by protein arginine N-methyltransferase 1
  • Phosphorylated at Thr-188 and Thr-315 by PKR in response to certain RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication.
  • Ubiquitination at Lys17, Lys100, Lys202, Lys257, Lys332, Lys413, Lys540, and Lys577
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ILF3 Gene

Domains for ILF3 Gene

Protein Domains for ILF3 Gene

Graphical View of Domain Structure for InterPro Entry

Q12906

UniProtKB/Swiss-Prot:

ILF3_HUMAN :
  • Q12906
Domain:
  • Contains 2 DRBM (double-stranded RNA-binding) domains.
  • Contains 1 DZF domain.
genes like me logo Genes that share domains with ILF3: view

No data available for Gene Families for ILF3 Gene

Function for ILF3 Gene

Molecular function for ILF3 Gene

UniProtKB/Swiss-Prot Function:
May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).

Gene Ontology (GO) - Molecular Function for ILF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 10574923
GO:0003723 RNA binding NAS 10400669
GO:0003725 double-stranded RNA binding IDA 10574923
GO:0005515 protein binding IPI 10574923
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ILF3: view
genes like me logo Genes that share phenotypes with ILF3: view

Animal Models for ILF3 Gene

MGI Knock Outs for ILF3:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ILF3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ILF3 Gene

Localization for ILF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ILF3 Gene

Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral dsRNA. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ILF3 Gene COMPARTMENTS Subcellular localization image for ILF3 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 1

Gene Ontology (GO) - Cellular Components for ILF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10400669
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 21123651
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with ILF3: view

Pathways for ILF3 Gene

SuperPathways for ILF3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ILF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation IDA 21123651
GO:0017148 negative regulation of translation ISS --
GO:0045071 negative regulation of viral genome replication ISS --
GO:0045892 negative regulation of transcription, DNA-templated IDA 11739746
genes like me logo Genes that share ontologies with ILF3: view

No data available for Pathways by source for ILF3 Gene

Compounds for ILF3 Gene

(3) Novoseek inferred chemical compound relationships for ILF3 Gene

Compound -log(P) Hits PubMed IDs
nf 45 98.9 43
tacrolimus 28.7 2
cyclosporin a 20.6 3
genes like me logo Genes that share compounds with ILF3: view

Transcripts for ILF3 Gene

Unigene Clusters for ILF3 Gene

Interleukin enhancer binding factor 3, 90kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ILF3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ILF3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: - -
SP7: -
SP8: -
SP9: - -
SP10:
SP11: -
SP12:

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b
SP1: - -
SP2: -
SP3: - -
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10: - - - -
SP11:
SP12:

Relevant External Links for ILF3 Gene

GeneLoc Exon Structure for
ILF3
ECgene alternative splicing isoforms for
ILF3

Expression for ILF3 Gene

mRNA expression in normal human tissues for ILF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ILF3 Gene

SOURCE GeneReport for Unigene cluster for ILF3 Gene Hs.465885

mRNA Expression by UniProt/SwissProt for ILF3 Gene

Q12906-ILF3_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with ILF3: view

Expression partners for ILF3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for ILF3 Gene

Orthologs for ILF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ILF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ILF3 35
  • 89.78 (n)
  • 96.21 (a)
ILF3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ILF3 35
  • 91.05 (n)
  • 97.77 (a)
ILF3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ilf3 35
  • 86.97 (n)
  • 93.17 (a)
Ilf3 16
Ilf3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ILF3 35
  • 99.28 (n)
  • 99.14 (a)
ILF3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ilf3 35
  • 87.76 (n)
  • 93.39 (a)
oppossum
(Monodelphis domestica)
Mammalia ILF3 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
ManyToMany
-- 36
  • 11 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 93 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 87 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ILF3 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ilf3 35
  • 71.72 (n)
  • 78.24 (a)
Str.20533 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3647 35
zebrafish
(Danio rerio)
Actinopterygii Dr.20053 35
ilf3b 35
  • 64.69 (n)
  • 67.12 (a)
ilf3b 36
  • 68 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12225 35
worm
(Caenorhabditis elegans)
Secernentea Y95B8A.8 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5593 36
  • 4 (a)
ManyToMany
Species with no ortholog for ILF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ILF3 Gene

ENSEMBL:
Gene Tree for ILF3 (if available)
TreeFam:
Gene Tree for ILF3 (if available)

Paralogs for ILF3 Gene

Paralogs for ILF3 Gene

genes like me logo Genes that share paralogs with ILF3: view

Variants for ILF3 Gene

Sequence variations from dbSNP and Humsavar for ILF3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs8271 -- 10,689,592(+) TGTCT(A/G)TTCAC utr-variant-3-prime
rs13465 -- 10,692,116(+) CTGGC(A/G)GGGAA utr-variant-3-prime
rs892087 -- 10,684,117(-) GGGTC(A/G)AGGGC intron-variant
rs1061243 -- 10,689,805(+) TACAT(C/T)TGAAT utr-variant-3-prime
rs1064493 - 10,671,118(+) GGATA(C/G)ACGAG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ILF3 Gene

Variant ID Type Subtype PubMed ID
nsv833745 CNV Loss 17160897
nsv911047 CNV Loss 21882294
nsv911048 CNV Loss 21882294
esv1002882 CNV Deletion 20482838
nsv833746 CNV Loss 17160897

Relevant External Links for ILF3 Gene

HapMap Linkage Disequilibrium report
ILF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ILF3 Gene

Disorders for ILF3 Gene

(1) Novoseek inferred disease relationships for ILF3 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for ILF3

Genetic Association Database (GAD)
ILF3
Human Genome Epidemiology (HuGE) Navigator
ILF3
genes like me logo Genes that share disorders with ILF3: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for ILF3 Gene

Publications for ILF3 Gene

  1. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. (PMID: 7519613) Kao P.N. … Corthesy B. (J. Biol. Chem. 1994) 2 3 4 23
  2. DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. (PMID: 9442054) Ting N.S.Y. … Lees-Miller S.P. (J. Biol. Chem. 1998) 3 4 23
  3. DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR. (PMID: 10400669) Patel R.C. … Sen G.C. (J. Biol. Chem. 1999) 3 4 23
  4. Autoantibodies define a family of proteins with conserved double- stranded RNA-binding domains as well as DNA binding activity. (PMID: 10574923) Satoh M. … Reeves W.H. (J. Biol. Chem. 1999) 3 4 23
  5. Molecular cloning and characterization of a translational inhibitory protein that binds to coding sequences of human acid beta-glucosidase and other mRNAs. (PMID: 10607473) Xu Y.-H. … Grabowski G.A. (Mol. Genet. Metab. 1999) 3 4 23

Products for ILF3 Gene

Sources for ILF3 Gene

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