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Aliases for ILF3 Gene

Aliases for ILF3 Gene

  • Interleukin Enhancer Binding Factor 3 2 3 5
  • M-Phase Phosphoprotein 4 2 3 4
  • Interleukin Enhancer Binding Factor 3, 90kDa 2 3
  • Interleukin Enhancer Binding Factor 3, 90kD 2 3
  • Nuclear Factor Of Activated T-Cells 90 KDa 3 4
  • Nuclear Factor Associated With DsRNA 3 4
  • Translational Control Protein 80 3 4
  • MPHOSPH4 3 4
  • NF-AT-90 3 4
  • DRBP76 3 4
  • TCP80 3 4
  • DRBF 3 4
  • MPP4 3 4
  • NF90 3 4
  • NFAR 3 4
  • Double-Stranded RNA-Binding Protein, 76 KD 3
  • Nuclear Factor Of Activated T-Cells, 90 KD 3
  • Double-Stranded RNA-Binding Protein 76 4
  • DsRNA Binding Protein NFAR-2/MPP4 3
  • NF110b 3
  • NFAR-1 3
  • TCP110 3
  • NF110 3
  • NF90a 3
  • NF90b 3
  • NFAR2 3
  • CBTF 3
  • MMP4 3

External Ids for ILF3 Gene

Previous GeneCards Identifiers for ILF3 Gene

  • GC19P010895
  • GC19P010987
  • GC19P010610
  • GC19P010764
  • GC19P010342

Summaries for ILF3 Gene

Entrez Gene Summary for ILF3 Gene

  • This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]

GeneCards Summary for ILF3 Gene

ILF3 (Interleukin Enhancer Binding Factor 3) is a Protein Coding gene. Diseases associated with ILF3 include ovarian mucinous cystadenocarcinoma and neurofibrosarcoma. GO annotations related to this gene include poly(A) RNA binding and double-stranded RNA binding. An important paralog of this gene is ZFR.

UniProtKB/Swiss-Prot for ILF3 Gene

  • May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).

Gene Wiki entry for ILF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ILF3 Gene

Genomics for ILF3 Gene

Regulatory Elements for ILF3 Gene

Enhancers for ILF3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ILF3 on UCSC Golden Path with GeneCards custom track

Promoters for ILF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ILF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ILF3 Gene

Chromosome:
19
Start:
10,654,261 bp from pter
End:
10,692,419 bp from pter
Size:
38,159 bases
Orientation:
Plus strand

Genomic View for ILF3 Gene

Genes around ILF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ILF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ILF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ILF3 Gene

Proteins for ILF3 Gene

  • Protein details for ILF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12906-ILF3_HUMAN
    Recommended name:
    Interleukin enhancer-binding factor 3
    Protein Accession:
    Q12906
    Secondary Accessions:
    • A8K6F2
    • G5E9M5
    • O43409
    • Q6P1X1
    • Q86XY7
    • Q99544
    • Q99545
    • Q9BZH4
    • Q9BZH5
    • Q9NQ95
    • Q9NQ96
    • Q9NQ97
    • Q9NQ98
    • Q9NQ99
    • Q9NQA0
    • Q9NQA1
    • Q9NQA2
    • Q9NRN2
    • Q9NRN3
    • Q9NRN4
    • Q9UMZ9
    • Q9UN00
    • Q9UN84
    • Q9UNA2

    Protein attributes for ILF3 Gene

    Size:
    894 amino acids
    Molecular mass:
    95338 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with FUS and SMN proteins and with PRMT1. Forms a complex with ILF2. Can also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of XRCC6/KU70 and XRCC5/KU80. Forms a heteromeric complex with ZNF346 and ILF3. Found in a nuclear export complex with XPO5, ILF3, Ran and double-stranded RNA or double-stranded minihelix VA1 RNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5 and ZNF346. Forms a complex with ILF2, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Interacts with AGO1 and AGO2.
    SequenceCaution:
    • Sequence=AAA20994.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAH48314.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ILF3 Gene

    Alternative splice isoforms for ILF3 Gene

neXtProt entry for ILF3 Gene

Proteomics data for ILF3 Gene at MOPED

Post-translational modifications for ILF3 Gene

  • Arg-609 is dimethylated, probably to asymmetric dimethylarginine.
  • Methylated by protein arginine N-methyltransferase 1.
  • Phosphorylated at Thr-188 and Thr-315 by PKR in response to certain RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication.
  • Ubiquitination at Lys 17, Lys 100, Lys 202, Lys 257, Lys 332, Lys 413, and Lys 577
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ILF3 Gene

Domains & Families for ILF3 Gene

Protein Domains for ILF3 Gene

Graphical View of Domain Structure for InterPro Entry

Q12906

UniProtKB/Swiss-Prot:

ILF3_HUMAN :
  • Contains 2 DRBM (double-stranded RNA-binding) domains.
Domain:
  • Contains 2 DRBM (double-stranded RNA-binding) domains.
  • Contains 1 DZF domain.
genes like me logo Genes that share domains with ILF3: view

No data available for Gene Families for ILF3 Gene

Function for ILF3 Gene

Molecular function for ILF3 Gene

UniProtKB/Swiss-Prot Function:
May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).

Gene Ontology (GO) - Molecular Function for ILF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 7519613
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ILF3: view
genes like me logo Genes that share phenotypes with ILF3: view

Animal Models for ILF3 Gene

MGI Knock Outs for ILF3:

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ILF3 Gene

Localization for ILF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ILF3 Gene

Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral dsRNA. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ILF3 Gene COMPARTMENTS Subcellular localization image for ILF3 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for ILF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IDA 21123651
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with ILF3: view

Pathways & Interactions for ILF3 Gene

SuperPathways for ILF3 Gene

No Data Available

SIGNOR curated interactions for ILF3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ILF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017148 negative regulation of translation IEA,ISS --
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with ILF3: view

No data available for Pathways by source for ILF3 Gene

Drugs & Compounds for ILF3 Gene

(2) Drugs for ILF3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ILF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ILF3: view

Transcripts for ILF3 Gene

Unigene Clusters for ILF3 Gene

Interleukin enhancer binding factor 3, 90kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ILF3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: - -
SP7: -
SP8: -
SP9: - -
SP10:
SP11: -
SP12:

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b
SP1: - -
SP2: -
SP3: - -
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10: - - - -
SP11:
SP12:

Relevant External Links for ILF3 Gene

GeneLoc Exon Structure for
ILF3
ECgene alternative splicing isoforms for
ILF3

Expression for ILF3 Gene

mRNA expression in normal human tissues for ILF3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ILF3 Gene



SOURCE GeneReport for Unigene cluster for ILF3 Gene Hs.465885

mRNA Expression by UniProt/SwissProt for ILF3 Gene

Q12906-ILF3_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ILF3: view

Protein tissue co-expression partners for ILF3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for ILF3 Gene

Orthologs for ILF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ILF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ILF3 35
  • 89.78 (n)
  • 96.21 (a)
ILF3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ILF3 35
  • 91.05 (n)
  • 97.77 (a)
ILF3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ilf3 35
  • 86.97 (n)
  • 93.17 (a)
Ilf3 16
Ilf3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ILF3 35
  • 99.28 (n)
  • 99.14 (a)
ILF3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ilf3 35
  • 87.76 (n)
  • 93.39 (a)
oppossum
(Monodelphis domestica)
Mammalia ILF3 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
ManyToMany
-- 36
  • 11 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 93 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 87 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ILF3 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ilf3 35
  • 71.72 (n)
  • 78.24 (a)
Str.20533 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3647 35
zebrafish
(Danio rerio)
Actinopterygii Dr.20053 35
ilf3b 35
  • 64.69 (n)
  • 67.12 (a)
ilf3b 36
  • 68 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12225 35
worm
(Caenorhabditis elegans)
Secernentea Y95B8A.8 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5593 36
  • 4 (a)
ManyToMany
Species with no ortholog for ILF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ILF3 Gene

ENSEMBL:
Gene Tree for ILF3 (if available)
TreeFam:
Gene Tree for ILF3 (if available)

Paralogs for ILF3 Gene

Paralogs for ILF3 Gene

genes like me logo Genes that share paralogs with ILF3: view

Variants for ILF3 Gene

Sequence variations from dbSNP and Humsavar for ILF3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1064493 - 10,671,118(+) GGATA(C/G)ACGAG upstream-variant-2KB, reference, missense
rs34520379 - 10,682,657(+) TAGAA(G/T)CTGTC reference, missense
rs12976026 -- 10,667,269(+) ttttt(G/T)gagac intron-variant
rs12976577 -- 10,667,497(+) GATCC(A/G)CCCGC intron-variant
rs8099926 -- 10,667,971(+) GGTCT(A/G)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ILF3 Gene

Variant ID Type Subtype PubMed ID
nsv833745 CNV Loss 17160897
nsv911047 CNV Loss 21882294
nsv911048 CNV Loss 21882294
esv1002882 CNV Deletion 20482838
nsv833746 CNV Loss 17160897

Variation tolerance for ILF3 Gene

Residual Variation Intolerance Score: 1.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ILF3 Gene

HapMap Linkage Disequilibrium report
ILF3
Human Gene Mutation Database (HGMD)
ILF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ILF3 Gene

Disorders for ILF3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ILF3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovarian mucinous cystadenocarcinoma
  • mucinous cystadenocarcinoma of ovary
neurofibrosarcoma
  • neurosarcoma [obs]
- elite association - COSMIC cancer census association via MalaCards
Search ILF3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ILF3

Genetic Association Database (GAD)
ILF3
Human Genome Epidemiology (HuGE) Navigator
ILF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ILF3
genes like me logo Genes that share disorders with ILF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ILF3 Gene

Publications for ILF3 Gene

  1. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. (PMID: 7519613) Kao P.N. … Corthesy B. (J. Biol. Chem. 1994) 2 3 4 23 67
  2. NF45 and NF90 regulate HS4-dependent interleukin-13 transcription in T cells. (PMID: 20051514) Kiesler P. … Vercelli D. (J. Biol. Chem. 2010) 3 23
  3. The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway. (PMID: 19398578) Sakamoto S. … Agata Y. (Mol. Cell. Biol. 2009) 3 23
  4. Nuclear factor 90 negatively regulates influenza virus replication by interacting with viral nucleoprotein. (PMID: 19494010) Wang P. … Chen H. (J. Virol. 2009) 3 23
  5. Nuclear factor 45 (NF45) is a regulatory subunit of complexes with NF90/110 involved in mitotic control. (PMID: 18458058) Guan D. … Mathews M.B. (Mol. Cell. Biol. 2008) 3 23

Products for ILF3 Gene

Sources for ILF3 Gene

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