Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ILF3 Gene

protein-coding GIFtS: 55
GCID: GC19P010764

interleukin enhancer binding factor 3, 90kDa

(Previous names: interleukin enhancer binding factor 3, 90kD )

Explore 16 diseases affiliated with
ILF3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin Enhancer Binding Factor 3, 90kDa¹ ²		Interleukin Enhancer Binding Factor 3, 90kD¹
DRBP76¹ ² ³ ⁵		CBTF²
MPHOSPH4¹ ² ³ ⁵		MMP4²
NF90¹ ² ³ ⁵		NF110²
MPP4¹ ² ³		NF110b²
NFAR² ³ ⁵		NF90a²
NFAR-1¹ ²		NF90b²
Nuclear Factor Associated With DsRNA² ³		NFAR2²
Nuclear Factor Of Activated T-Cells 90 KDa² ³		TCP110²
Translational Control Protein 80² ³		Double-Stranded RNA-Binding Protein, 76 KD²
DRBF² ³		DsRNA Binding Protein NFAR-2/MPP4²
NF-AT-90² ³		Interleukin Enhancer-Binding Factor 3²
TCP80² ³		Nuclear Factor Of Activated T-Cells, 90 KD²
M-Phase Phosphoprotein 4² ³		Double-Stranded RNA-Binding Protein 76³

External Ids:	HGNC: 6038¹	Entrez Gene: 3609²	Ensembl: ENSG00000129351⁷	OMIM: 603182⁵	UniProtKB: Q12906³

Export aliases for ILF3 gene to outside databases

Previous GC identifers: GC19P010895 GC19P010987 GC19P010610 GC19P010625 GC19P010342

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ILF3:

This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small

noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a

subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of

interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene.

These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or

NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of

this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are

reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.(provided by RefSeq,

Nov 2008)

UniProtKB/Swiss-Prot: ILF3_HUMAN, Q12906

Function: May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a

translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and

functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can

regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell

activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA

Gene Wiki entry for ILF3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ILF3 gene promoter:
HEN1 TBP USF1 USF-1 USF2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ILF3 promoter sequence

Search SABiosciences Chromatin IP Primers for ILF3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ILF3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2

ILF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ILF3 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P010764: view genomic region (about GC identifiers)

Start:	10,764,937 bp from pter	End:	10,803,095 bp from pter
Size:	38,159 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ILF3_HUMAN, Q12906 (See protein sequence)

Recommended Name: Interleukin enhancer-binding factor 3

Size: 894 amino acids; 95338 Da

Subunit: Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2,

PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9,

ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL,

PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts

with FUS and SMN proteins and with PRMT1. Forms a complex with ILF2. Can also bind to PRKDC/XRCC7: this may stabilize

the interaction of PRKDC/XRCC7 and the heterodimeric complex of XRCC6/KU70 and XRCC5/KU80. Forms a heteromeric complex

with ZNF346 and ILF3. Found in a nuclear export complex with XPO5, ILF3, Ran and double-stranded RNA or

double-stranded minihelix VA1 RNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded

RNA. Interacts with XPO5 and ZNF346. Forms a complex with ILF2, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Interacts with

EIF2C1 and EIF2C2

Subcellular location: Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing

untranslated mRNAs

Sequence caution: Sequence=AAA20994.1; Type=Miscellaneous discrepancy; Note=Sequencing errors; Sequence=AAH48314.1;

Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

2 PDB 3D structures from and Proteopedia for ILF3:

2L33 (3D)

3P1X (3D)

Secondary accessions: A8K6F2 O43409 Q6P1X1 Q86XY7 Q99544 Q99545 Q9BZH4 Q9BZH5 Q9NQ95 Q9NQ96 Q9NQ97

Q9NQ98 Q9NQ99 Q9NQA0 Q9NQA1 Q9NQA2 Q9NRN2 Q9NRN3 Q9NRN4 Q9UMZ9 Q9UN00 Q9UN84 Q9UNA2

Alternative splicing: 6 isoforms: Q12906-1 Q12906-2 Q12906-3 Q12906-4 Q12906-5 Q12906-6 (Contains a phosphoserine at position 482)

Explore the universe of human proteins at neXtProt for ILF3: NX_Q12906

Post-translational modifications:

Phosphorylated by RNA-dependent protein kinase (EIF2AK2)¹

Methylated by protein arginine N-methyltransferase 1¹

Arg-609 is dimethylated, probably to asymmetric dimethylarginine¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q12906

ILF3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001131145.1 NP_004507.2 NP_036350.2 NP_060090.2 NP_703194.1

ENSEMBL proteins:

ENSP00000384660 ENSP00000465219 ENSP00000468134 ENSP00000466396 ENSP00000465654

ENSP00000468323 ENSP00000466991 ENSP00000468092 ENSP00000250241 ENSP00000465515

ENSP00000468181 ENSP00000468156 ENSP00000464974 ENSP00000467704 ENSP00000465831

ENSP00000467950 ENSP00000467372 ENSP00000466724 ENSP00000466235 ENSP00000404121

ENSP00000315205 ENSP00000405436

Human Recombinant Protein Products for ILF3:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ILF3 OriGene Protein Over-expression Lysate: ILF3 OriGene Custom Protein Services for ILF3
	GenScript Custom Purified and Recombinant Proteins Services for ILF3
	Novus Biologicals ILF3 Proteins Novus Biologicals ILF3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ILF3

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	NAS	10400669
GO:0005730	nucleolus	IEA	--
GO:0005739	mitochondrion	IDA	--
GO:0030529	ribonucleoprotein complex	IDA	17289661

ILF3 for ontologies About GeneDecksing

ILF3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): ILF3 OriGene Custom Antibody Services for ILF3
	GenScript Superior Antibodies for ILF3
	Novus Biologicals ILF3 Antibodies
	Abcam antibodies for ILF3
	Uscn Antibodies for ILF3
	ThermoFisher Antibodies for ILF3

Assay Products for ILF3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ILF3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ILF3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ILF3 for domains About GeneDecksing

3 InterPro domains/families:

IPR001159 Ds-RNA-bd

IPR014720 dsRNA-bd-like_dom

IPR006561 DZF

Graphical View of Domain Structure for InterPro Entry Q12906

ProtoNet protein and cluster: Q12906

1 Blocks protein family: IPB001159 Double-stranded RNA binding (DsRBD) domain

UniProtKB/Swiss-Prot: ILF3_HUMAN, Q12906

Similarity: Contains 2 DRBM (double-stranded RNA-binding) domains

Similarity: Contains 1 DZF domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ILF3_HUMAN, Q12906

Function: May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a

translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and

functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can

regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell

activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IDA	10574923
GO:0003723	RNA binding	NAS	10400669
GO:0003725	double-stranded RNA binding	IDA	10574923
GO:0005515	protein binding	IPI	10749851

ILF3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ILF3:

Increased G1 DNA content

8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ilf3):

behavior/neurological	cellular	growth/size	homeostasis/metabolism	immune system
mortality/aging	muscle	respiratory system

ILF3 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Ilf3^tm1Pnk for ILF3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ILF3

miRNA Products:		OriGene 3'-UTR Clone (see all 5): ILF3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ILF3
		8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate ILF3 (see all 85):
		hsa-miR-548j hsa-miR-3130-5p hsa-miR-607 hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-1260b hsa-miR-371-5p hsa-miR-550a*

		SwitchGear 3'UTR luciferase reporter plasmid: ILF3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ILF3 (see all 7) OriGene shRNA RFP: ILF3 OriGene siRNA: ILF3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ILF3
		Sirion Biotech Custom design and validation of potent shRNA sequences against ILF3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ILF3
			Sirion Biotech Customized adenovirus for overexpression of ILF3 Sirion Biotech Customized adenovirus for potent knockdown of ILF3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ILF3 (see all 10) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ILF3 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): ILF3 (NM_012218)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ILF3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ILF3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ILF3
		Search LifeMap BioReagents cell lines for ILF3
		Sirion Biotech Customized stable knockdown cell line services for ILF3 Sirion Biotech Customized inducible knockdown cell line services for ILF3 Sirion Biotech Customized stable overexpressing cell line services for ILF3 Sirion Biotech Customized inducible overexpressing cell line services for ILF3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ILF3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ILF3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/732 Interacting proteins for ILF3 (Q12906^{1, 2, 3} ENSP00000404121⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 732)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ILF2	Q12905²^,³, ENSP00000355011⁴	MINT-8076150 MINT-8076195 MINT-6488791 MINT-7945693 MINT-8076167 MINT-8076181 MINT-8076347 MINT-8076071 MINT-8076236 I2D: score=2 STRING: ENSP00000355011
PRKDC	P78527²^,³, ENSP00000313420⁴	MINT-7945693 MINT-8076071 MINT-8076347 MINT-8076236 I2D: score=1 STRING: ENSP00000313420
DHX9	Q08211²^,³, ENSP00000356520⁴	MINT-6488791 MINT-7945693 I2D: score=2 STRING: ENSP00000356520
SMN2	Q16637²^,³, ENSP00000370119⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000370119
GDF9	O60383²^,³, ENSP00000296875⁴	MINT-64088 I2D: score=4 STRING: ENSP00000296875

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000279	M phase	NAS	8885239
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0045892	negative regulation of transcription, DNA-dependent	IDA	11739746
GO:0045893	positive regulation of transcription, DNA-dependent	IDA	11739746

ILF3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ILF3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ILF3
3 Novoseek chemical compound relationships for ILF3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nf 45	98.9	54	18458058 (5), 17942973 (5), 9442054 (4), 9843854 (4) (see all 16)
tacrolimus	28.7	2	7519613 (2)
cyclosporin a	20.6	3	7519613 (2), 9843854 (1)

Search CenterWatch for drugs/clinical trials and news about ILF3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ILF3 gene (5 alternative transcripts):

NM_001137673.1 NM_004516.3 NM_012218.3 NM_017620.2 NM_153464.2

Unigene Cluster for ILF3:

Interleukin enhancer binding factor 3, 90kDa

Hs.465885 [show with all ESTs]

Unigene Representative Sequence: NM_017620

18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):

ENST00000587928 ENST00000407004(uc002mpm.2 uc002mpp.3) ENST00000589998

ENST00000589600 ENST00000589283 ENST00000590009 ENST00000593199 ENST00000587505

ENST00000589052 ENST00000250241(uc002mpl.2) ENST00000592763 ENST00000588657

ENST00000590261 ENST00000587941 ENST00000587840 ENST00000589416 ENST00000585835

ENST00000589485

miRNA Products:		OriGene 3'-UTR Clone (see all 5): ILF3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ILF3
		8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate ILF3 (see all 85):
		hsa-miR-548j hsa-miR-3130-5p hsa-miR-607 hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-1260b hsa-miR-371-5p hsa-miR-550a*

		SwitchGear 3'UTR luciferase reporter plasmid: ILF3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ILF3 (see all 7) OriGene shRNA RFP: ILF3 OriGene siRNA: ILF3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ILF3
		Sirion Biotech Custom design and validation of potent shRNA sequences against ILF3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ILF3 (see all 10) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ILF3 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): ILF3 (NM_012218)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ILF3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ILF3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ILF3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ILF3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ILF3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ILF3

Additional cDNA sequence:

AF007140.1 AF141870.1 AF167569.1 AF167570.1 AJ271744.1 AJ271745.1 AJ271746.1 AK000018.1

AK023222.1 AK025821.1 AK291205.1 AK291617.1 AK293170.1 AK294084.1 AL832528.1 AY240961.1

BC001770.1 BC003086.1 BC014221.2 BC018633.2 BC048314.1 BC064836.1 CR457223.1 HQ322263.1

HQ322264.1 HQ322265.1 U10324.1 X98264.1 X98265.1

24/45 DOTS entries (see all 45):

DT.443764 DT.95326855 DT.100737828 DT.100051454 DT.100737905 DT.100737762 DT.99926713 DT.99926723

DT.95170613 DT.95343275 DT.100737833 DT.92463379 DT.121436290 DT.92463377 DT.95349861 DT.97860656

DT.100833554 DT.121436280 DT.121436330 DT.95170610 DT.95170618 DT.97819449 DT.100876567 DT.91896863

24/1019 AceView cDNA sequences (see all 1019):

AU123620 AI476507 BQ927555 AI146620 AL535349 BC064836 AJ271747 AI857572

BM848232 AA911536 AI910879 AA923731 AA359662 NM_004516 AA720966 N35021

BG340011 AI796466 CB139173 AF167570 AI086043 AI208808 F10457 BQ228750

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ILF3 (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	·	14c	^	15a	·	15b	·	15c	·	15d	^	16a	·	16b	^
SP1:							-		-																								-														-
SP2:							-		-																																						-
SP3:																																	-														-		-
SP4:																																	-														-		-
SP5:																																															-		-

ExUns:	17	^	18a	·	18b	^	19	^	20a	·	20b	^	21a	·	21b	^	22	^	23a	·	23b
SP1:									-		-
SP2:											-
SP3:									-		-
SP4:
SP5:									-		-

ECgene alternative splicing isoforms for ILF3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ILF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAAGTAAC

About this image

ILF3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Skeletal Muscle

Mandibular Arch Muscles

Myoblasts

Skeletal Muscle

Heart

Right Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ILF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ILF3

SOURCE GeneReport for Unigene cluster: Hs.465885

UniProtKB/Swiss-Prot: ILF3_HUMAN, Q12906

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for ILF3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ILF3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ILF3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ILF3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ILF3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ILF3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ILF3 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	ILF3⁶	--	86(a)	1 ↔ 1	2(80588038-80616881)
African clawed frog (Xenopus laevis)	Amphibia	Xl.3647²	Xenopus laevis dsRNA-binding protein 4F.1 mRNA, complete more	76.61(n)		AY008299.1
zebrafish (Danio rerio)	Actinopterygii	Dr.20053²	Danio rerio, clone IMAGE3815279, mRNA, partial cds	77.83(n)		BC047175.1
fruit fly (Drosophila melanogaster)	Insecta	Zn72D⁶	Zinc-finger protein at 72D	18(a)	1 → many	3L(16099694-16105726)
worm (Caenorhabditis elegans)	Secernentea	Y95B8A.8⁶	--	13(a)	possible ortholog	I(853454-871950)

ENSEMBL Gene Tree for ILF3 (if available)
TreeFam Gene Tree for ILF3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ILF3 gene

ZFR2² ILF2² STRBP² ZFR²

3 SIMAP similar genes for ILF3 using alignment to 16 protein entries: ILF3_HUMAN (see all proteins):

STRBP DKFZp434P151 ZFR

ILF3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114206806^1,2		--	10762966(+)	`AAAACT/GTGTTC`	6	--	us2k¹ nc-transcript-variant		1		WA	118
rs191563172^1,2		--	10762999(+)	`CCCCTA/GCCACA`	6	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs118102170^1,2	F	--	10763007(+)	`ACATAA/CTCACA`	6	--	us2k¹ nc-transcript-variant		1		EA	120
rs59252610^1,2	C	--	10763215(+)	`TTTTT-/TTGAGGC`	6	--	nc-transcript-variantus2k¹		2		NA	4
rs139982368^1,2		--	10763426(+)	`TTGGCC/TAGGCT`	6	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs117982595^1,2	F	--	10763540(+)	`CACCTC/GCTTGC`	6	--	us2k¹ nc-transcript-variant		1		NA	120
rs113586052^1,2		--	10763632(+)	`CGCCTG/ACCAGG`	6	--	nc-transcript-variantus2k¹		1		CSA	2
rs184139066^1,2		--	10763690(+)	`CATGTA/GCCACC`	6	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs144776959^1,2		--	10763720(+)	`TTGTAA/TTTTTA`	6	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs111723989^1,2		--	10763755(+)	`GGCCAG/AGCTGG`	6	--	us2k¹ nc-transcript-variant		1		CSA	2

HapMap Linkage Disequilibrium report for ILF3 (10764937 - 10803095 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ILF3
1 CNV: 5086

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ILF3

DNA2.0 Custom Variant and Variant Library Synthesis for ILF3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ILF3 for disorders           About GeneDecksing

OMIM gene information: 603182    OMIM disorders: --

16 diseases for ILF3:    About MalaCards

treacher collins syndrome metastasis efficiency myocardial infarction hepatitis c

hepatitis b kidney disease ovarian cancer nasopharyngitis

hepatitis influenza lung cancer prostate cancer

breast cancer hypertension prostatitis carcinoma

1 Novoseek disease relationship for ILF3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	2	16322899 (1), 19088038 (1)

Human Genome Epidemiology (HuGE) Navigator: ILF3 (4 documents)

Export disorders for ILF3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ILF3 gene, integrated from 9 sources (see all 139):
(articles sorted by number of sources associating them with ILF3)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. (PubMed id 7519613)^{1, 2, 3, 9} Kao P.N.... Corthesy B. (1994)
Identification of novel M phase phosphoproteins by expression cloning. (PubMed id 8885239)^{1, 2, 3} Matsumoto-Taniura N....Westendorf J.M. (1996)
Molecular cloning and characterization of a translational inhibitory protein that binds to coding sequences of human acid beta-glucosidase and other mRNAs. (PubMed id 10607473)^{1, 2, 9} Xu Y.-H. and Grabowski G.A. (1999)
Alternative splicing in the human interleukin enhancer binding factor 3 (ILF3) gene. (PubMed id 11167023)^{1, 2, 9} Duchange N.... Sauvaget D. (2000)
DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. (PubMed id 9442054)^{1, 2, 9} Ting N.S.Y.... Lees-Miller S.P. (1998)
Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3. (PubMed id 14570900)^{1, 2, 9} Gwizdek C....Dargemont C. (2004)
The 90- and 110-kDa human NFAR proteins are translated from two differentially spliced mRNAs encoded on chromosome 19p13. (PubMed id 11161820)^{1, 2, 9} Saunders L.R.... Barber G.N. (2001)
Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR. (PubMed id 11438536)^{1, 2, 9} Saunders L.R.... Barber G.N. (2001)
Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin- 5. (PubMed id 15254228)^{1, 2, 9} Chen T.... Macara I.G. (2004)
Exportin-5, a novel karyopherin, mediates nuclear export of double- stranded RNA binding proteins. (PubMed id 11777942)^{1, 2, 9} Brownawell A.M. and Macara I.G. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3609	HGNC: 6038	AceView: ILF3	Ensembl:ENSG00000129351	euGenes: HUgn3609
ECgene: ILF3	H-InvDB: ILF3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ILF3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ILF3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ILF3 gene:
Search GeneIP for patents involving ILF3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for ILF3		OriGene shRNA RFP for ILF3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ILF3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ILF3
	OriGene Protein Over-expression Lysate for ILF3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ILF3		OriGene 3'-UTR Clone for ILF3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ILF3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ILF3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for ILF3		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ILF3		OriGene Custom Protein Services for ILF3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ILF3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ILF3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ILF3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ILF3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ILF3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ILF3

	GenScript Custom Purified and Recombinant Proteins Services for ILF3		GenScript cDNA clones with any tag delivered in your preferred vector for ILF3
	GenScript Custom Assay Services for ILF3		GenScript Superior Antibodies for ILF3
	GenScript Custom overexpressing Cell Line Services for ILF3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ILF3 promoter
	Search Chromatin IP Primers for ILF3
	RT² qPCR Primer Assay in human, mouse, rat ILF3
	GNC Network for ILF3
	SABiosciences Custom PCR Arrays for ILF3

Search Tocris compounds for ILF3

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ILF3 antibodies
	ILF3 proteins
	ILF3 lysates

	Antibodies for ILF3
	See all of Abcam's Antibodies, Kits and Proteins for ILF3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ILF3 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ILF3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ILF3

	SwitchGear 3'UTR luciferase reporter plasmids for ILF3
	SwitchGear Promoter luciferase reporter plasmids for ILF3

ThermoFisher Antibodies for ILF3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ILF3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ILF3

Sirion Biotech Customized:

	stable knockdown cell line services for ILF3
	inducible knockdown cell line services for ILF3
	design and validation of potent shRNA sequences against ILF3
	adenovirus for potent knockdown of ILF3
	adenovirus for overexpression of ILF3
	stable overexpressing cell line services for ILF3
	inducible overexpressing cell line services for ILF3

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ILF3 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

ILF3 Gene

interleukin enhancer binding factor 3, 90kDa

Aliases
for ILF3 gene

Summaries
for ILF3 gene

Genomic Views
for ILF3 gene

Proteins
for ILF3 gene

Protein Domains /
Families
for ILF3 gene

Function
for ILF3 gene

Pathways & Interactions
for ILF3 gene

Drugs & Compounds
for ILF3 gene

Transcripts
for ILF3 gene

Expression
for ILF3 gene

Orthologs
for ILF3 gene

Paralogs
for ILF3 gene

Genomic Variants
for ILF3 gene

Disorders / Diseases
for ILF3 gene

Publications
for ILF3 gene

External Searches for ILF3 gene

Genome Databases showing ILF3 gene

Other Databases showing ILF3 gene

Specialized Databases showing ILF3 gene

Intellectual Property
for ILF3 gene

Products
for ILF3 gene

View Random Gene

ILF3 (Gene Symbol)
Interleukin Enhancer Binding Factor 3, 90kDa
DRBP76
MPHOSPH4
NF90
MPP4
NFAR
NFAR-1
Nuclear Factor Associated With DsRNA
Nuclear Factor Of Activated T-Cells 90 KDa
Translational Control Protein 80
DRBF
NF-AT-90
TCP80
M-Phase Phosphoprotein 4
Interleukin Enhancer Binding Factor 3, 90kD
CBTF
MMP4
NF110
NF110b
NF90a
NF90b
NFAR2
TCP110
Double-Stranded RNA-Binding Protein, 76 KD
DsRNA Binding Protein NFAR-2/MPP4
Interleukin Enhancer-Binding Factor 3
Nuclear Factor Of Activated T-Cells, 90 KD
Double-Stranded RNA-Binding Protein 76

Advanced Search

Export list of displayed genes

ILF3 Gene

interleukin enhancer binding factor 3, 90kDa

Aliasesfor ILF3 gene

Summariesfor ILF3 gene

Genomic Viewsfor ILF3 gene

Proteinsfor ILF3 gene

Protein Domains /Familiesfor ILF3 gene

Functionfor ILF3 gene

Pathways & Interactionsfor ILF3 gene

Drugs & Compoundsfor ILF3 gene

Transcriptsfor ILF3 gene

Expression for ILF3 gene

Orthologsfor ILF3 gene

Paralogsfor ILF3 gene

Genomic Variantsfor ILF3 gene

Disorders / Diseasesfor ILF3 gene

Publicationsfor ILF3 gene

External Searches for ILF3 gene

Genome Databases showing ILF3 gene

Other Databases showing ILF3 gene

Specialized Databases showing ILF3 gene

Intellectual Propertyfor ILF3 gene

Productsfor ILF3 gene

View Random Gene

Aliases
for ILF3 gene

Summaries
for ILF3 gene

Genomic Views
for ILF3 gene

Proteins
for ILF3 gene

Protein Domains /
Families
for ILF3 gene

Function
for ILF3 gene

Pathways & Interactions
for ILF3 gene

Drugs & Compounds
for ILF3 gene

Transcripts
for ILF3 gene

Expression
for ILF3 gene

Orthologs
for ILF3 gene

Paralogs
for ILF3 gene

Genomic Variants
for ILF3 gene

Disorders / Diseases
for ILF3 gene

Publications
for ILF3 gene

Intellectual Property
for ILF3 gene

Products
for ILF3 gene