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Aliases for ILF3 Gene

Aliases for ILF3 Gene

  • Interleukin Enhancer Binding Factor 3 2 3 5
  • M-Phase Phosphoprotein 4 2 3 4
  • Interleukin Enhancer Binding Factor 3, 90kDa 2 3
  • Interleukin Enhancer Binding Factor 3, 90kD 2 3
  • Nuclear Factor Of Activated T-Cells 90 KDa 3 4
  • Nuclear Factor Associated With DsRNA 3 4
  • Translational Control Protein 80 3 4
  • MPHOSPH4 3 4
  • NF-AT-90 3 4
  • DRBP76 3 4
  • TCP80 3 4
  • DRBF 3 4
  • MPP4 3 4
  • NF90 3 4
  • NFAR 3 4
  • Double-Stranded RNA-Binding Protein, 76 KD 3
  • Nuclear Factor Of Activated T-Cells, 90 KD 3
  • Double-Stranded RNA-Binding Protein 76 4
  • Interleukin Enhancer-Binding Factor 3 3
  • DsRNA Binding Protein NFAR-2/MPP4 3
  • NF110b 3
  • NFAR-1 3
  • TCP110 3
  • NF110 3
  • NF90a 3
  • NF90b 3
  • NFAR2 3
  • CBTF 3
  • MMP4 3

External Ids for ILF3 Gene

Previous GeneCards Identifiers for ILF3 Gene

  • GC19P010895
  • GC19P010987
  • GC19P010610
  • GC19P010764
  • GC19P010342

Summaries for ILF3 Gene

Entrez Gene Summary for ILF3 Gene

  • This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]

GeneCards Summary for ILF3 Gene

ILF3 (Interleukin Enhancer Binding Factor 3) is a Protein Coding gene. Diseases associated with ILF3 include Ovarian Mucinous Cystadenocarcinoma. GO annotations related to this gene include poly(A) RNA binding and double-stranded RNA binding. An important paralog of this gene is STRBP.

UniProtKB/Swiss-Prot for ILF3 Gene

  • May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).

Gene Wiki entry for ILF3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ILF3 Gene

Genomics for ILF3 Gene

Regulatory Elements for ILF3 Gene

Enhancers for ILF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G010601 1.7 FANTOM5 ENCODE dbSUPER 12.5 -50.1 -50138 4.4 ARID4B DMAP1 ZNF2 ZNF766 ZNF143 SP3 SP5 REST TBX21 ZNF610 SLC44A2 CDKN2D KRI1 ICAM3 ILF3 QTRT1 ZNF627 PRKCSH RPL10P15 ILF3-AS1
GH19G010595 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.6 -58.1 -58061 2.0 USF1 ZSCAN4 MAX EBF1 EGR1 ADNP RELB ETV6 IKZF2 MTA2 KRI1 CDKN2D SLC44A2 ICAM3 ATG4D ILF3 TYK2 DNM2 C19orf38 S1PR5
GH19G010729 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +77.2 77166 4.1 HDGF CTCF FOXA2 PKNOX1 MAX ZIC2 POLR2A ADNP NR2F6 ZSCAN29 SLC44A2 CDKN2D KRI1 ILF3 ILF3-AS1 S1PR5 SMARCA4 DNM2 ICAM3 TYK2
GH19G010514 1.6 FANTOM5 ENCODE dbSUPER 11.6 -137.0 -137045 5.2 PKNOX1 FOXA2 SIN3A ZNF2 ZNF48 ZNF121 GLIS2 KLF7 ZNF263 SP3 S1PR5 KRI1 ATG4D ZNF846 LOC100419831 CDKN2D SLC44A2 RNU7-140P MIR1238 ILF3
GH19G010552 1.4 Ensembl ENCODE dbSUPER 11.5 -100.1 -100125 5.3 HDGF PKNOX1 AGO1 KLF17 RAD21 GLIS2 SCRT2 FOS ETV6 EGR2 KRI1 CDKN2D SLC44A2 ILF3 QTRT1 ILF3-AS1 MIR1238
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ILF3 on UCSC Golden Path with GeneCards custom track

Promoters for ILF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107059 39 3001 CREB3L1 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263

Genomic Location for ILF3 Gene

Chromosome:
19
Start:
10,654,261 bp from pter
End:
10,692,419 bp from pter
Size:
38,159 bases
Orientation:
Plus strand

Genomic View for ILF3 Gene

Genes around ILF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ILF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ILF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ILF3 Gene

Proteins for ILF3 Gene

  • Protein details for ILF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12906-ILF3_HUMAN
    Recommended name:
    Interleukin enhancer-binding factor 3
    Protein Accession:
    Q12906
    Secondary Accessions:
    • A8K6F2
    • G5E9M5
    • O43409
    • Q6P1X1
    • Q86XY7
    • Q99544
    • Q99545
    • Q9BZH4
    • Q9BZH5
    • Q9NQ95
    • Q9NQ96
    • Q9NQ97
    • Q9NQ98
    • Q9NQ99
    • Q9NQA0
    • Q9NQA1
    • Q9NQA2
    • Q9NRN2
    • Q9NRN3
    • Q9NRN4
    • Q9UMZ9
    • Q9UN00
    • Q9UN84
    • Q9UNA2

    Protein attributes for ILF3 Gene

    Size:
    894 amino acids
    Molecular mass:
    95338 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with FUS and SMN proteins and with PRMT1. Forms a complex with ILF2. Can also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of XRCC6/KU70 and XRCC5/KU80. Forms a heteromeric complex with ZNF346 and ILF3. Found in a nuclear export complex with XPO5, ILF3, Ran and double-stranded RNA or double-stranded minihelix VA1 RNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5 and ZNF346. Forms a complex with ILF2, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Interacts with AGO1 and AGO2.
    SequenceCaution:
    • Sequence=AAA20994.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAH48314.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ILF3 Gene

    Alternative splice isoforms for ILF3 Gene

neXtProt entry for ILF3 Gene

Post-translational modifications for ILF3 Gene

  • Arg-609 is dimethylated, probably to asymmetric dimethylarginine.
  • Methylated by protein arginine N-methyltransferase 1.
  • Phosphorylated at Thr-188 and Thr-315 by PKR in response to certain RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication.
  • Ubiquitination at posLast=1717, posLast=100100, posLast=202202, isoforms=2, 3, 4, 5, 6, 7257, isoforms=2, 3, 4, 5, 6, 7332, isoforms=2, 3, 4, 5, 6, 7413, and isoforms=2, 3, 4, 5, 6, 7577
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ILF3 Gene

Domains & Families for ILF3 Gene

Protein Domains for ILF3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ILF3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ILF3 Gene

Function for ILF3 Gene

Molecular function for ILF3 Gene

UniProtKB/Swiss-Prot Function:
May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).

Gene Ontology (GO) - Molecular Function for ILF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 7519613
GO:0003723 RNA binding NAS 10400669
GO:0003725 double-stranded RNA binding IDA 10574923
GO:0005515 protein binding IPI 9442054
genes like me logo Genes that share ontologies with ILF3: view
genes like me logo Genes that share phenotypes with ILF3: view

Animal Models for ILF3 Gene

MGI Knock Outs for ILF3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ILF3 Gene

Localization for ILF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ILF3 Gene

Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral dsRNA. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ILF3 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for ILF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10400669
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IDA 21123651
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with ILF3: view

Pathways & Interactions for ILF3 Gene

No Data Available

SIGNOR curated interactions for ILF3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ILF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation IDA 21123651
GO:0017148 negative regulation of translation ISS,IEA --
GO:0045071 negative regulation of viral genome replication ISS,IEA --
genes like me logo Genes that share ontologies with ILF3: view

No data available for Pathways by source for ILF3 Gene

Drugs & Compounds for ILF3 Gene

(2) Drugs for ILF3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ILF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ILF3: view

Transcripts for ILF3 Gene

Unigene Clusters for ILF3 Gene

Interleukin enhancer binding factor 3, 90kDa:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ILF3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: - -
SP7: -
SP8: -
SP9: - -
SP10:
SP11: -
SP12:

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b
SP1: - -
SP2: -
SP3: - -
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10: - - - -
SP11:
SP12:

Relevant External Links for ILF3 Gene

GeneLoc Exon Structure for
ILF3
ECgene alternative splicing isoforms for
ILF3

Expression for ILF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ILF3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ILF3 Gene



Protein tissue co-expression partners for ILF3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ILF3 Gene:

ILF3

SOURCE GeneReport for Unigene cluster for ILF3 Gene:

Hs.465885

mRNA Expression by UniProt/SwissProt for ILF3 Gene:

Q12906-ILF3_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ILF3 Gene

  • Nervous system(4.9)
  • Intestine(4.7)
  • Liver(4.5)
  • Blood(4.4)
  • Skin(3.8)
  • Lung(3.6)
  • Eye(3.4)
  • Pancreas(2.7)
  • Kidney(2.3)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with ILF3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ILF3 Gene

Orthologs for ILF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ILF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ILF3 34 35
  • 99.28 (n)
oppossum
(Monodelphis domestica)
Mammalia ILF3 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
ManyToMany
-- 35
  • 64 (a)
ManyToMany
-- 35
  • 61 (a)
ManyToMany
-- 35
  • 11 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia ILF3 34 35
  • 91.05 (n)
cow
(Bos Taurus)
Mammalia ILF3 34 35
  • 89.78 (n)
rat
(Rattus norvegicus)
Mammalia Ilf3 34
  • 87.76 (n)
mouse
(Mus musculus)
Mammalia Ilf3 34 16 35
  • 86.97 (n)
chicken
(Gallus gallus)
Aves -- 35
  • 87 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ILF3 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ilf3 34
  • 71.72 (n)
Str.20533 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3647 34
zebrafish
(Danio rerio)
Actinopterygii ilf3b 34 35
  • 64.69 (n)
Dr.20053 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12225 34
worm
(Caenorhabditis elegans)
Secernentea Y95B8A.8 35
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5593 35
  • 4 (a)
ManyToMany
Species where no ortholog for ILF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ILF3 Gene

ENSEMBL:
Gene Tree for ILF3 (if available)
TreeFam:
Gene Tree for ILF3 (if available)

Paralogs for ILF3 Gene

Paralogs for ILF3 Gene

genes like me logo Genes that share paralogs with ILF3: view

Variants for ILF3 Gene

Sequence variations from dbSNP and Humsavar for ILF3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000108372 -- 10,652,476(+) AAGCC(A/G)TTCTT nc-transcript-variant, upstream-variant-2KB
rs1000131095 -- 10,666,195(+) GTCTT(C/G)AACTC intron-variant
rs1000159157 -- 10,652,268(+) AAGTA(A/G)GCTGG nc-transcript-variant, upstream-variant-2KB
rs1000247357 -- 10,688,890(+) GGTAC(C/G)TGTGT intron-variant
rs1000327142 -- 10,661,056(+) AAAGG(A/G)CAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ILF3 Gene

Variant ID Type Subtype PubMed ID
esv1002882 CNV deletion 20482838
esv3643657 CNV loss 21293372
nsv1160584 CNV deletion 26073780
nsv1160585 CNV deletion 26073780
nsv833745 CNV loss 17160897
nsv833746 CNV loss 17160897

Variation tolerance for ILF3 Gene

Residual Variation Intolerance Score: 1.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ILF3 Gene

Human Gene Mutation Database (HGMD)
ILF3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ILF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ILF3 Gene

Disorders for ILF3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ILF3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian mucinous cystadenocarcinoma
  • mucinous cystadenocarcinoma of ovary
- elite association - COSMIC cancer census association via MalaCards
Search ILF3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ILF3

Genetic Association Database (GAD)
ILF3
Human Genome Epidemiology (HuGE) Navigator
ILF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ILF3
genes like me logo Genes that share disorders with ILF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ILF3 Gene

Publications for ILF3 Gene

  1. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. (PMID: 7519613) Kao P.N. … Corthesy B. (J. Biol. Chem. 1994) 2 3 4 22 64
  2. Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3. (PMID: 14570900) Gwizdek C. … Dargemont C. (J. Biol. Chem. 2004) 3 4 22 64
  3. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin- 5. (PMID: 15254228) Chen T. … Macara I.G. (Mol. Cell. Biol. 2004) 3 4 22 64
  4. Exportin-5, a novel karyopherin, mediates nuclear export of double- stranded RNA binding proteins. (PMID: 11777942) Brownawell A.M. … Macara I.G. (J. Cell Biol. 2002) 3 4 22 64
  5. The 90- and 110-kDa human NFAR proteins are translated from two differentially spliced mRNAs encoded on chromosome 19p13. (PMID: 11161820) Saunders L.R. … Barber G.N. (Genomics 2001) 3 4 22 64

Products for ILF3 Gene

Sources for ILF3 Gene

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