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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ILF2 Gene

protein-coding   GIFtS: 55
GCID: GC01M153634

Interleukin Enhancer Binding Factor 2

(Previous names: interleukin enhancer binding factor 2, 45kD, interleukin...)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin Enhancer Binding Factor 21 2     PRO30632
Interleukin Enhancer Binding Factor 2, 45kD1 2     Interleukin Enhancer-Binding Factor 22
Interleukin Enhancer Binding Factor 2, 45kDa1 2     Nuclear Factor Of Activated T-Cells, 45-KDa2
NF452 3     Nuclear Factor Of Activated T-Cells 45 KDa3

External Ids:    HGNC: 60371   Entrez Gene: 36082   Ensembl: ENSG000001436217   OMIM: 6031815   UniProtKB: Q129053   

Export aliases for ILF2 gene to outside databases

Previous GC identifers: GC01M151483 GC01M149365 GC01M150409 GC01M150851 GC01M150447 GC01M151900 GC01M124997


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ILF2 Gene:
The protein encoded by this gene is the 45 kDa component of nuclear factor of activated T-cells (NFAT), a
heterodimer of 45 kDa and 90 kDa proteins. NFAT is a transcription factor required for T-cell expression of the
interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of
hepatitis B viral polymerase. The complex has been shown to repair DNA breaks by nonhomologous end joining and
can also negatively regulate the microRNA processing pathway. Alternative splicing results in multiple transcript
variants. Related pseudogenes have been found on chromosomes 3 and 14. (provided by RefSeq, Jun 2012)

GeneCards Summary for ILF2 Gene: 
ILF2 (interleukin enhancer binding factor 2) is a protein-coding gene. Diseases associated with ILF2 include hepatitis b, and pthirus pubis infestation. GO annotations related to this gene include double-stranded RNA binding and transferase activity. An important paralog of this gene is ZFR2.

UniProtKB/Swiss-Prot: ILF2_HUMAN, Q12905
Function: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate
transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent
protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and
isoform 2) into the nucleus

Gene Wiki entry for ILF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ILF2 gene promoter:
         E2F-4   E2F-3a   NF-1/L   E2F-5   E2F-2   GATA-1   E2F-1   E2F   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidILF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ILF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ILF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

ILF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ILF2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153634:  view genomic region     (about GC identifiers)

Start:
153,634,512 bp from pter      End:
153,643,524 bp from pter
Size:
9,013 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ILF2_HUMAN, Q12905 (See protein sequence)
Recommended Name: Interleukin enhancer-binding factor 2  
Size: 390 amino acids; 43062 Da
Subunit: Forms heterodimers with ILF3. ILF2-ILF3 heterodimers may also bind to PRKDC/XRCC7: this may stabilize the
interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80. Forms a complex with ILF3,
YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4,
DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1,
NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs.
Interacts with IGF2BP1
Subcellular location: Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules
containing untranslated mRNAs
Sequence caution: Sequence=AAA20993.1; Type=Frameshift; Positions=376; Sequence=AAF29591.1; Type=Miscellaneous
discrepancy; Note=Chimeric cDNA; Sequence=CAI13611.1; Type=Erroneous gene model prediction;
Secondary accessions: A6NDB0 B2R8G7 Q5SR10 Q5SR11 Q7L7R3 Q9BWD4 Q9P1N0

Explore the universe of human proteins at neXtProt for ILF2: NX_Q12905

Explore proteomics data for ILF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12905

  • ILF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ILF2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001254738.1  NP_004506.2  

    ENSEMBL proteins: 
     ENSP00000355011   ENSP00000357673   ENSP00000357670  

    Human Recombinant Protein Products for ILF2: 
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    Novus Biologicals ILF2 Proteins
    Novus Biologicals ILF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ILF2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0030529ribonucleoprotein complex IDA17289661

    ILF2 for ontologies           About GeneDecksing



    ILF2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for ILF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR006561 DZF
     IPR006116 2-5-oligoadenylate_synth_N

    Graphical View of Domain Structure for InterPro Entry Q12905

    ProtoNet protein and cluster: Q12905

    UniProtKB/Swiss-Prot: ILF2_HUMAN, Q12905
    Similarity: Contains 1 DZF domain


    ILF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ILF2_HUMAN, Q12905
    Function: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate
    transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent
    protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and
    isoform 2) into the nucleus

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA10574923
    GO:0003723RNA binding ----
    GO:0003725double-stranded RNA binding IDA10574923
    GO:0005515protein binding IPI10574923
    GO:0005524ATP binding IEA--
         
    ILF2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ILF2:
     Decreased melanin production  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ilf2):
     immune system  mortality/aging 

    ILF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ilf2tm1Pnk for ILF2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ILF2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ILF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ILF2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ILF2 

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    hsa-miR-513b hsa-miR-1305
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ILF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ILF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1085 Interacting proteins for ILF2 (Q129051, 2, 3 ENSP000003550114) via UniProtKB, MINT, STRING, and/or I2D (see all 1085)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ILF3Q129062, 3, ENSP000004041214MINT-8076150 MINT-8076195 MINT-6488791 MINT-8076167 MINT-7945693 MINT-8076181 MINT-8076071 MINT-8076347 MINT-8076236 I2D: score=2 STRING: ENSP00000404121
    RAD50Q928782, ENSP000002653354MINT-8076150 MINT-8076195 MINT-7947479 MINT-8076209 MINT-7945693 MINT-8076167 MINT-8076181 MINT-8076071 MINT-8076347 MINT-8076236 STRING: ENSP00000265335
    EEF1A1P681042, ENSP000003300544MINT-6489539 MINT-6488590 MINT-7947479 MINT-6488791 MINT-7945693 MINT-6489355 MINT-8076071 MINT-8076347 MINT-8076236 STRING: ENSP00000330054
    SF3A2Q154282, 3, ENSP000002214944MINT-5206232 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    NFKB2Q006532, 3, ENSP000001894444MINT-48700 I2D: score=2 STRING: ENSP00000189444
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IDA11739746
    GO:0006955immune response IEA--
    GO:0045893positive regulation of transcription, DNA-dependent IDA11739746

    ILF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ILF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ILF2

    3 Novoseek inferred chemical compound relationships for ILF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nf 45 99.5 85 16533607 (8), 18458058 (7), 17942973 (7), 15817156 (6) (see all 19)
    tacrolimus 41.6 2 7519613 (2)
    cyclosporin a 34.3 2 7519613 (2)

    Search CenterWatch for drugs/clinical trials and news about ILF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ILF2 gene (2 alternative transcripts): 
    NM_001267809.1  NM_004515.3  

    Unigene Cluster for ILF2:

    Interleukin enhancer binding factor 2
    Hs.75117  [show with all ESTs]
    Unigene Representative Sequence: NM_001267809
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361891(uc001fcr.3 uc010pdy.2 uc009wol.1) ENST00000480213
    ENST00000368684 ENST00000368681
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ILF2:
    hsa-miR-513b hsa-miR-1305
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ILF2

    Additional mRNA sequence: 

    AK223326.1 AK302214.1 AK313364.1 BC000382.2 HQ322261.1 HQ322262.1 U10323.1 

    24/41 DOTS entries (see all 41):

    DT.97862522  DT.91794779  DT.100860717  DT.91854541  DT.100684382  DT.95294855  DT.100835596  DT.100678194 
    DT.87018008  DT.100831620  DT.121394402  DT.100804456  DT.100767566  DT.121394386  DT.95294905  DT.95294910 
    DT.91920385  DT.100651106  DT.121394334  DT.91794832  DT.95294862  DT.95294904  DT.121394371  DT.95294914 

    24/997 AceView cDNA sequences (see all 997):

    T49548 H47547 BM857109 BU839748 AL047461 AA620594 CR623082 BM743793 
    BU181863 T32015 BP366761 NM_004515 BM912321 BG236049 BM790303 BG389495 
    BX407819 BQ181887 BP369393 R19790 CF541087 BM700926 BM974027 BG698679 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ILF2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                -           -           -           -     -           -           -                 -                                 
    SP2:                                -           -           -           -     -                                                                           
    SP3:                                            -           -           -     -           -           -     -           -                                 
    SP4:                                            -           -                                                                                             
    SP5:                                -           -           -                                                                                             


    ECgene alternative splicing isoforms for ILF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ILF2 expression in normal human tissues (normalized intensities)      ILF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGACAGACA
    ILF2 Expression
    About this image


    ILF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See ILF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ILF2

    SOURCE GeneReport for Unigene cluster: Hs.75117
        SABiosciences Custom PCR Arrays for ILF2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ILF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ILF2 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ilf21 , 5 interleukin enhancer binding factor 21, 5 91.54(n)1
    100(a)1
      3 (39.23 cM)5
    677811  NM_026374.31  NP_080650.11 
     904762015 
    chicken
    (Gallus gallus)
    Aves ILF21 interleukin enhancer binding factor 2, 45kDa 80.17(n)
    95.9(a)
      425709  XM_423437.3  XP_423437.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia ilf2-prov2 interleukin enhancer binding factor 2, 45kDa 75.87(n)    BC043981.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb34h012 Danio rerio cDNA clone MGC73084 IMAGE4199523, complete more 78.61(n)    BC059456.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG56411 , 3 CG56411 58(a)3
    59.29(n)1
    58.07(a)1
      87B103
    415291  NM_141939.31  NP_650196.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R11H6.53
    CELE_R11H6.51
    Human NF45 protein like3
    Protein R11H6.51
    36(a)3
    45.66(n)1
    38.46(a)1
      V(14613494-14614750)3
    1799651  NM_074213.31  NP_506614.11 


    ENSEMBL Gene Tree for ILF2 (if available)
    TreeFam Gene Tree for ILF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ILF2 gene
    ZFR22  STRBP2  ILF32  ZFR2  

    ILF2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ILF2
    PGOHUM00000247771 PGOHUM00000238049


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/264 SNPs in ILF2 are shown (see all 264)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs793472081,2
    C--153634946(+) CTCTCC/TTTCCT 4 R G mis10--------
    rs1858181481,2
    C--153635060(+) TTAGAC/TGAGTA 2 -- int10--------
    rs2012705481,2
    --153635062(+) AGACGA/GGTAGC 2 -- int10--------
    rs1897886151,2
    C--153635194(+) TCACCC/TTCCTG 4 E syn10--------
    rs1502915611,2
    --153635384(+) AGTCTA/TTCAGA 2 -- int10--------
    rs37953961,2
    C,F,A,H--153635425(+) ATTCCA/GCTTTG 2 -- int130Minor allele frequency- G:0.35EA NA NS WA CSA 3993
    rs1379440331,2
    C--153635652(+) ACAAAA/CTAGTT 2 -- int10--------
    rs2007642981,2
    --153635667(+) ACCAAC/TCCTAA 2 -- int10--------
    rs1148785101,2
    C,F--153635675(+) TAAACC/GCAAAG 2 -- int11Minor allele frequency- G:0.09WA 118
    rs1115924961,2
    C--153635753(+) TGGCCC/G/TTGAAA 2 -- spa11CSA 1

    HapMap Linkage Disequilibrium report for ILF2 (153634512 - 153643524 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ILF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv464028CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ILF2
    DNA2.0 Custom Variant and Variant Library Synthesis for ILF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603181    OMIM disorders: --

    6 diseases for ILF2:    About MalaCards
    hepatitis b    pthirus pubis infestation    hepatitis    hepatitis c
    hepatocellular carcinoma    breast cancer


    ILF2 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: ILF2 (1 document)

    Export disorders for ILF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ILF2 gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with ILF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. (PubMed id 7519613)1, 2, 3, 9 Kao P.N.... Corthesy B. (1994)
    2. DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. (PubMed id 9442054)1, 2, 9 Ting N.S.Y.... Lees-Miller S.P. (1998)
    3. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    7. The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells. (PubMed id 11739746)1, 2 Reichman T.W.... Mathews M.B. (2002)
    8. Directed proteomic analysis of the human nucleolus. (PubMed id 11790298)1, 2 Andersen J.S.... Lamond A.I. (2002)
    9. Autoantibodies define a family of proteins with conserved double- stranded RNA-binding domains as well as DNA binding activity. (PubMed id 10574923)1, 2 Satoh M.... Reeves W.H. (1999)
    10. Nuclear factor 45 (NF45) is a regulatory subunit of complexes with NF90/110 involved in mitotic control. (PubMed id 18458058)1, 9 Guan D....Mathews M.B. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3608 HGNC: 6037 AceView: ILF2 Ensembl:ENSG00000143621 euGenes: HUgn3608
    ECgene: ILF2 H-InvDB: ILF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ILF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ILF2 gene:
    Search GeneIP for patents involving ILF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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     Regulatory tfbs in ILF2 promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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