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Aliases for ILF2 Gene

Aliases for ILF2 Gene

  • Interleukin Enhancer Binding Factor 2 2 3
  • Interleukin Enhancer Binding Factor 2, 45kDa 2 3
  • Interleukin Enhancer Binding Factor 2, 45kD 2 3
  • NF45 3 4
  • Nuclear Factor Of Activated T-Cells, 45-KDa 3
  • Nuclear Factor Of Activated T-Cells 45 KDa 4
  • Interleukin Enhancer-Binding Factor 2 3
  • PRO3063 3

External Ids for ILF2 Gene

Previous GeneCards Identifiers for ILF2 Gene

  • GC01M151483
  • GC01M149365
  • GC01M150409
  • GC01M150851
  • GC01M150447
  • GC01M151900
  • GC01M124997

Summaries for ILF2 Gene

Entrez Gene Summary for ILF2 Gene

  • The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]

GeneCards Summary for ILF2 Gene

ILF2 (Interleukin Enhancer Binding Factor 2) is a Protein Coding gene. Diseases associated with ILF2 include hepatitis b and hepatitis. GO annotations related to this gene include double-stranded RNA binding and transferase activity. An important paralog of this gene is ZFR2.

UniProtKB/Swiss-Prot for ILF2 Gene

  • Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus.

Gene Wiki entry for ILF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ILF2 Gene

Genomics for ILF2 Gene

Regulatory Elements for ILF2 Gene

Genomic Location for ILF2 Gene

Start:
153,661,788 bp from pter
End:
153,671,048 bp from pter
Size:
9,261 bases
Orientation:
Minus strand

Genomic View for ILF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ILF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ILF2 Gene

Proteins for ILF2 Gene

  • Protein details for ILF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12905-ILF2_HUMAN
    Recommended name:
    Interleukin enhancer-binding factor 2
    Protein Accession:
    Q12905
    Secondary Accessions:
    • A6NDB0
    • B2R8G7
    • Q5SR10
    • Q5SR11
    • Q7L7R3
    • Q9BWD4
    • Q9P1N0

    Protein attributes for ILF2 Gene

    Size:
    390 amino acids
    Molecular mass:
    43062 Da
    Quaternary structure:
    • Forms heterodimers with ILF3. ILF2-ILF3 heterodimers may also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80. Forms a complex with ILF3, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with IGF2BP1.
    SequenceCaution:
    • Sequence=AAA20993.1; Type=Frameshift; Positions=376; Evidence={ECO:0000305}; Sequence=AAF29591.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=CAI13611.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ILF2 Gene

Proteomics data for ILF2 Gene at MOPED

Post-translational modifications for ILF2 Gene

  • Ubiquitination at Lys45, Lys59, and Lys141
  • Modification sites at PhosphoSitePlus

Other Protein References for ILF2 Gene

Antibody Products

No data available for DME Specific Peptides for ILF2 Gene

Domains for ILF2 Gene

Protein Domains for ILF2 Gene

Suggested Antigen Peptide Sequences for ILF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12905

UniProtKB/Swiss-Prot:

ILF2_HUMAN :
  • Q12905
Domain:
  • Contains 1 DZF domain.
genes like me logo Genes that share domains with ILF2: view

No data available for Gene Families for ILF2 Gene

Function for ILF2 Gene

Molecular function for ILF2 Gene

UniProtKB/Swiss-Prot Function:
Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus.

Gene Ontology (GO) - Molecular Function for ILF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 10574923
GO:0003723 RNA binding --
GO:0003725 double-stranded RNA binding IDA 10574923
GO:0005515 protein binding IPI 10574923
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ILF2: view

Phenotypes for ILF2 Gene

MGI mutant phenotypes for ILF2:
inferred from 1 alleles
GenomeRNAi human phenotypes for ILF2:
genes like me logo Genes that share phenotypes with ILF2: view

Animal Models for ILF2 Gene

MGI Knock Outs for ILF2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ILF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ILF2 Gene

Localization for ILF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ILF2 Gene

Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ILF2 Gene COMPARTMENTS Subcellular localization image for ILF2 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ILF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21123651
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA 11790298
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ILF2: view

Pathways for ILF2 Gene

SuperPathways for ILF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ILF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IDA 11739746
GO:0006955 immune response IEA --
GO:0008152 metabolic process --
GO:0045893 positive regulation of transcription, DNA-templated IDA 11739746
genes like me logo Genes that share ontologies with ILF2: view

No data available for Pathways by source for ILF2 Gene

Compounds for ILF2 Gene

(3) Novoseek inferred chemical compound relationships for ILF2 Gene

Compound -log(P) Hits PubMed IDs
nf 45 99.5 69
tacrolimus 41.6 2
cyclosporin a 34.3 2
genes like me logo Genes that share compounds with ILF2: view

Transcripts for ILF2 Gene

Unigene Clusters for ILF2 Gene

Interleukin enhancer binding factor 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ILF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ILF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -
SP8:
SP9:

Relevant External Links for ILF2 Gene

GeneLoc Exon Structure for
ILF2
ECgene alternative splicing isoforms for
ILF2

Expression for ILF2 Gene

mRNA expression in normal human tissues for ILF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ILF2 Gene

SOURCE GeneReport for Unigene cluster for ILF2 Gene Hs.75117

genes like me logo Genes that share expressions with ILF2: view

Expression partners for ILF2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ILF2 Gene

Orthologs for ILF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ILF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ILF2 35
  • 94.02 (n)
  • 99.74 (a)
ILF2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ILF2 35
  • 93.25 (n)
  • 100 (a)
ILF2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ilf2 35
  • 91.54 (n)
  • 100 (a)
Ilf2 16
Ilf2 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ILF2 35
  • 99.91 (n)
  • 100 (a)
ILF2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ILF2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ILF2 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves ILF2 35
  • 80.52 (n)
  • 96.87 (a)
ILF2 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75701 35
African clawed frog
(Xenopus laevis)
Amphibia ilf2-prov 35
zebrafish
(Danio rerio)
Actinopterygii ilf2 35
  • 77.71 (n)
  • 91.57 (a)
wufb34h01 35
ilf2 36
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1694 35
fruit fly
(Drosophila melanogaster)
Insecta CG5641 37
  • 58 (a)
CG5641 35
  • 60.83 (n)
  • 59.82 (a)
CG5641 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001997 35
  • 58.81 (n)
  • 61.33 (a)
worm
(Caenorhabditis elegans)
Secernentea R11H6.5 37
  • 36 (a)
CELE_R11H6.5 35
  • 45.9 (n)
  • 39.02 (a)
R11H6.5 36
  • 36 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3994 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5584 36
  • 58 (a)
OneToOne
Species with no ortholog for ILF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ILF2 Gene

ENSEMBL:
Gene Tree for ILF2 (if available)
TreeFam:
Gene Tree for ILF2 (if available)

Paralogs for ILF2 Gene

Paralogs for ILF2 Gene

Pseudogenes.org Pseudogenes for ILF2 Gene

genes like me logo Genes that share paralogs with ILF2: view

Variants for ILF2 Gene

Sequence variations from dbSNP and Humsavar for ILF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1130607 -- 153,662,377(-) CCTTT(C/T)CCTAC utr-variant-3-prime
rs3795396 -- 153,662,949(+) ATTCC(A/G)CTTTG intron-variant
rs3862047 -- 153,665,141(-) CTTAG(C/T)TTGTT intron-variant
rs4351684 -- 153,664,384(+) GTTAG(A/G)GAGGG intron-variant
rs4515830 -- 153,663,996(+) ACTAC(C/T)AGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ILF2 Gene

Variant ID Type Subtype PubMed ID
nsv464028 CNV Gain 19166990

Relevant External Links for ILF2 Gene

HapMap Linkage Disequilibrium report
ILF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ILF2 Gene

Disorders for ILF2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ILF2 Gene in MalaCards »

(2) Diseases for ILF2 Gene including...

Relevant External Links for ILF2

Human Genome Epidemiology (HuGE) Navigator
ILF2
genes like me logo Genes that share disorders with ILF2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ILF2 Gene

Publications for ILF2 Gene

  1. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. (PMID: 7519613) Kao P.N. … Corthesy B. (J. Biol. Chem. 1994) 2 3 4 23
  2. DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. (PMID: 9442054) Ting N.S.Y. … Lees-Miller S.P. (J. Biol. Chem. 1998) 3 4 23
  3. Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates. (PMID: 8974006) Marcoulatos P. … Vamvakopoulos N.C. (J. Interferon Cytokine Res. 1996) 3 23
  4. Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase. (PMID: 11438540) Parker L.M. … Mathews M.B. (J. Biol. Chem. 2001) 3 23
  5. NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function. (PMID: 15817156) Zhao G. … Kao P.N. (Exp. Cell Res. 2005) 3 23

Products for ILF2 Gene

Sources for ILF2 Gene

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