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ILF2 Gene

protein-coding   GIFtS: 56
GCID: GC01M153634

Interleukin Enhancer Binding Factor 2

(Previous names: interleukin enhancer binding factor 2, 45kD, interleukin...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin Enhancer Binding Factor 21 2     PRO30632
Interleukin Enhancer Binding Factor 2, 45kD1 2     Interleukin Enhancer-Binding Factor 22
Interleukin Enhancer Binding Factor 2, 45kDa1 2     Nuclear Factor Of Activated T-Cells, 45-KDa2
NF452 3     Nuclear Factor Of Activated T-Cells 45 KDa3

External Ids:    HGNC: 60371   Entrez Gene: 36082   Ensembl: ENSG000001436217   OMIM: 6031815   UniProtKB: Q129053   

Export aliases for ILF2 gene to outside databases

Previous GC identifers: GC01M151483 GC01M149365 GC01M150409 GC01M150851 GC01M150447 GC01M151900 GC01M124997


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ILF2 Gene:
The protein encoded by this gene is the 45 kDa component of nuclear factor of activated T-cells (NFAT), a
heterodimer of 45 kDa and 90 kDa proteins. NFAT is a transcription factor required for T-cell expression of the
interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of
hepatitis B viral polymerase. The complex has been shown to repair DNA breaks by nonhomologous end joining and
can also negatively regulate the microRNA processing pathway. Alternative splicing results in multiple transcript
variants. Related pseudogenes have been found on chromosomes 3 and 14. (provided by RefSeq, Jun 2012)

GeneCards Summary for ILF2 Gene:
ILF2 (interleukin enhancer binding factor 2) is a protein-coding gene. Diseases associated with ILF2 include hepatitis b, and pthirus pubis infestation. GO annotations related to this gene include double-stranded RNA binding and transferase activity. An important paralog of this gene is ZFR2.

UniProtKB/Swiss-Prot: ILF2_HUMAN, Q12905
Function: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate
transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent
protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and
isoform 2) into the nucleus

Gene Wiki entry for ILF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ILF2 gene promoter:
         E2F-4   E2F-3a   NF-1/L   E2F-5   E2F-2   GATA-1   E2F-1   E2F   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidILF2 promoter sequence
   Search Chromatin IP Primers for ILF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ILF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

ILF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ILF2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153634:  view genomic region     (about GC identifiers)

Start:
153,634,512 bp from pter      End:
153,643,524 bp from pter
Size:
9,013 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ILF2_HUMAN, Q12905 (See protein sequence)
Recommended Name: Interleukin enhancer-binding factor 2  
Size: 390 amino acids; 43062 Da
Subunit: Forms heterodimers with ILF3. ILF2-ILF3 heterodimers may also bind to PRKDC/XRCC7: this may stabilize the
interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80. Forms a complex with ILF3,
YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Identified in a IGF2BP1-dependent mRNP granule complex containing
untranslated mRNAs. Interacts with IGF2BP1
Sequence caution: Sequence=AAA20993.1; Type=Frameshift; Positions=376; Sequence=AAF29591.1; Type=Miscellaneous
discrepancy; Note=Chimeric cDNA; Sequence=CAI13611.1; Type=Erroneous gene model prediction;
Secondary accessions: A6NDB0 B2R8G7 Q5SR10 Q5SR11 Q7L7R3 Q9BWD4 Q9P1N0

Explore the universe of human proteins at neXtProt for ILF2: NX_Q12905

Explore proteomics data for ILF2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys45, Lys59, Lys141
  • Modification sites at PhosphoSitePlus

  • See ILF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001254738.1  NP_004506.2  

    ENSEMBL proteins: 
     ENSP00000355011   ENSP00000357673   ENSP00000357670  

    ILF2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for ILF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR006561 DZF
     IPR006116 2-5-oligoadenylate_synth_N

    Graphical View of Domain Structure for InterPro Entry Q12905

    ProtoNet protein and cluster: Q12905

    UniProtKB/Swiss-Prot: ILF2_HUMAN, Q12905
    Similarity: Contains 1 DZF domain


    ILF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ILF2_HUMAN, Q12905
    Function: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate
    transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent
    protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and
    isoform 2) into the nucleus

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA10574923
    GO:0003723RNA binding ----
    GO:0003725double-stranded RNA binding IDA10574923
    GO:0005515protein binding IPI10574923
    GO:0005524ATP binding IEA--
         
    ILF2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ILF2:
     Decreased melanin production  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ilf2):
     immune system  mortality/aging 

    ILF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ilf2tm1Pnk for ILF2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ILF2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ILF2

    miRNA
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    miRTarBase miRNAs that target ILF2:
    hsa-mir-31-5p (MIRT049906), hsa-mir-92a-3p (MIRT049279), hsa-mir-124-3p (MIRT022452), hsa-mir-23b-3p (MIRT046275), hsa-mir-484 (MIRT042209), hsa-mir-615-3p (MIRT040442), hsa-mir-181b-5p (MIRT047288), hsa-mir-940 (MIRT036602), hsa-mir-331-3p (MIRT043419), hsa-mir-149-5p (MIRT045674)

    Block miRNA regulation of human, mouse, rat ILF2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate ILF2:
    hsa-miR-513b hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidILF2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ILF2_HUMAN, Q12905: Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules
    containing untranslated mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0030529ribonucleoprotein complex IDA17289661

    ILF2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ILF2
    Interactions:

        GeneGlobe Interaction Network for ILF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ILF2 (Q129051, 2, 3 ENSP000003550114) via UniProtKB, MINT, STRING, and/or I2D (see all 1084)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ILF3Q129062, 3, ENSP000004041214MINT-8076150 MINT-8076195 MINT-6488791 MINT-8076167 MINT-7945693 MINT-8076181 MINT-8076071 MINT-8076347 MINT-8076236 I2D: score=2 STRING: ENSP00000404121
    RAD50Q928782, ENSP000002653354MINT-8076150 MINT-8076195 MINT-7947479 MINT-8076209 MINT-7945693 MINT-8076167 MINT-8076181 MINT-8076071 MINT-8076347 MINT-8076236 STRING: ENSP00000265335
    EEF1A1P681042, ENSP000003300544MINT-6489539 MINT-6488590 MINT-7947479 MINT-6488791 MINT-7945693 MINT-6489355 MINT-8076071 MINT-8076347 MINT-8076236 STRING: ENSP00000330054
    SF3A2Q154282, 3, ENSP000002214944MINT-5206232 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    NFKB2Q006532, 3, ENSP000001894444MINT-48700 I2D: score=2 STRING: ENSP00000189444
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IDA11739746
    GO:0006955immune response IEA--
    GO:0045893positive regulation of transcription, DNA-templated IDA11739746

    ILF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ILF2

    3 Novoseek inferred chemical compound relationships for ILF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nf 45 99.5 85 16533607 (8), 18458058 (7), 17942973 (7), 15817156 (6) (see all 19)
    tacrolimus 41.6 2 7519613 (2)
    cyclosporin a 34.3 2 7519613 (2)



    ILF2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ILF2 gene (2 alternative transcripts): 
    NM_001267809.1  NM_004515.3  

    Unigene Cluster for ILF2:

    Interleukin enhancer binding factor 2
    Hs.75117  [show with all ESTs]
    Unigene Representative Sequence: NM_001267809
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361891(uc001fcr.3 uc010pdy.2 uc009wol.1) ENST00000480213
    ENST00000368684 ENST00000368681
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ILF2:
    hsa-miR-513b hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidILF2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ILF2
      QuantiFast Probe-based Assays in human, mouse, rat ILF2

    Additional mRNA sequence: 

    AK223326.1 AK302214.1 AK313364.1 BC000382.2 HQ322261.1 HQ322262.1 U10323.1 

    Selected DOTS entries (see all 41):

    DT.97862522  DT.91794779  DT.100860717  DT.91854541  DT.100684382  DT.95294855  DT.100835596  DT.100678194 
    DT.87018008  DT.100831620  DT.121394402  DT.100804456  DT.100767566  DT.121394386  DT.95294905  DT.95294910 
    DT.91920385  DT.100651106  DT.121394334  DT.91794832  DT.95294862  DT.95294904  DT.121394371  DT.95294914 

    Selected AceView cDNA sequences (see all 997):

    CR616375 AI282335 CR608248 T31956 AA232117 BX382806 BX410836 BU627491 
    CR599497 CB160494 AA761402 BU147328 T49650 D31020 BX462757 AA336557 
    BX422139 BE300141 AA988709 BX337804 CB850628 BG252995 BX449870 BQ218189 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ILF2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                -           -           -           -     -           -           -                 -                                 
    SP2:                                -           -           -           -     -                                                                           
    SP3:                                            -           -           -     -           -           -     -           -                                 
    SP4:                                            -           -                                                                                             
    SP5:                                -           -           -                                                                                             


    ECgene alternative splicing isoforms for ILF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ILF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGACAGACA
    ILF2 Expression
    About this image


    ILF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
    ILF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ILF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75117
        Custom PCR Arrays for ILF2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ILF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ILF2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ilf21 , 5 interleukin enhancer binding factor 21, 5 91.54(n)1
    100(a)1
      3 (39.23 cM)5
    677811  NM_026374.31  NP_080650.11 
     904762015 
    chicken
    (Gallus gallus)
    Aves ILF21 interleukin enhancer binding factor 2, 45kDa 80.52(n)
    96.87(a)
      425709  XM_004948212.1  XP_004948269.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia ilf2-prov2 interleukin enhancer binding factor 2, 45kDa 75.87(n)    BC043981.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb34h012 Danio rerio cDNA clone MGC73084 IMAGE4199523, complete more 78.61(n)    BC059456.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG56411 , 3 CG56411 58(a)3
    60.83(n)1
    59.82(a)1
      87B103
    415291  NM_141939.31  NP_650196.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R11H6.53
    CELE_R11H6.51
    Human NF45 protein like3
    CELE_R11H6.51
    36(a)3
    45.9(n)1
    39.02(a)1
      V(14613494-14614750)3
    1799651  NM_074213.41  NP_506614.11 


    ENSEMBL Gene Tree for ILF2 (if available)
    TreeFam Gene Tree for ILF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ILF2 gene
    ZFR22  STRBP2  ILF32  ZFR2  

    ILF2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ILF2
    PGOHUM00000247771 PGOHUM00000238049


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ILF2 (see all 264)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs793472081,2
    C--153634946(+) CTCTCC/TTTCCT 4 R G mis10--------
    rs1858181481,2
    C--153635060(+) TTAGAC/TGAGTA 2 -- int10--------
    rs2012705481,2
    --153635062(+) AGACGA/GGTAGC 2 -- int10--------
    rs1897886151,2
    C--153635194(+) TCACCC/TTCCTG 4 E syn10--------
    rs1502915611,2
    --153635384(+) AGTCTA/TTCAGA 2 -- int10--------
    rs37953961,2
    C,F,A,H--153635425(+) ATTCCA/GCTTTG 2 -- int130Minor allele frequency- G:0.35EA NA NS WA CSA 3993
    rs1379440331,2
    C--153635652(+) ACAAAA/CTAGTT 2 -- int10--------
    rs2007642981,2
    --153635667(+) ACCAAC/TCCTAA 2 -- int10--------
    rs1148785101,2
    C,F--153635675(+) TAAACC/GCAAAG 2 -- int11Minor allele frequency- G:0.09WA 118
    rs1115924961,2
    C--153635753(+) TGGCCC/G/TTGAAA 2 -- spa11CSA 1

    HapMap Linkage Disequilibrium report for ILF2 (153634512 - 153643524 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ILF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv464028CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ILF2
    DNA2.0 Custom Variant and Variant Library Synthesis for ILF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603181    OMIM disorders: --

    18 diseases for ILF2:    
    About MalaCards
    hepatitis b    pthirus pubis infestation    hepatitis    treacher collins syndrome
    hepatitis c virus    hepatitis c    tonsillitis    hepatocellular carcinoma
    neuroblastoma    hiv-1    multiple myeloma    myeloma
    thyroiditis    breast cancer    cerebritis    malaria
    prostatitis    endotheliitis


    ILF2 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: ILF2 (1 document)

    Export disorders for ILF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ILF2 gene, integrated from 10 sources (see all 97):
    (articles sorted by number of sources associating them with ILF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. (PubMed id 7519613)1, 2, 3, 9 Kao P.N.... Corthesy B. (J. Biol. Chem. 1994)
    2. DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. (PubMed id 9442054)1, 2, 9 Ting N.S.Y.... Lees-Miller S.P. (J. Biol. Chem. 1998)
    3. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    7. The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells. (PubMed id 11739746)1, 2 Reichman T.W.... Mathews M.B. (Mol. Cell. Biol. 2002)
    8. Directed proteomic analysis of the human nucleolus. (PubMed id 11790298)1, 2 Andersen J.S.... Lamond A.I. (Curr. Biol. 2002)
    9. Autoantibodies define a family of proteins with conserved double- stranded RNA-binding domains as well as DNA binding activity. (PubMed id 10574923)1, 2 Satoh M.... Reeves W.H. (J. Biol. Chem. 1999)
    10. Nuclear factor 45 (NF45) is a regulatory subunit of complexes with NF90/110 involved in mitotic control. (PubMed id 18458058)1, 9 Guan D....Mathews M.B. (Mol. Cell. Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3608 HGNC: 6037 AceView: ILF2 Ensembl:ENSG00000143621 euGenes: HUgn3608
    ECgene: ILF2 H-InvDB: ILF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ILF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ILF2 gene:
    Search GeneIP for patents involving ILF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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