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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ILF2 Gene

protein-coding   GIFtS: 55
GCID: GC01M153634

interleukin enhancer binding factor 2

(Previous names: interleukin enhancer binding factor 2, 45kD, interleukin...)
 Explore 7 diseases affiliated with
ILF2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ILF2    

Aliases
for ILF2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interleukin Enhancer Binding Factor 21 2     PRO30632
NF451 2 3     Interleukin Enhancer-Binding Factor 22
Interleukin Enhancer Binding Factor 2, 45kD1 2     Nuclear Factor Of Activated T-Cells, 45-KDa2
Interleukin Enhancer Binding Factor 2, 45kDa1 2     Nuclear Factor Of Activated T-Cells 45 KDa3

External Ids:    HGNC: 60371   Entrez Gene: 36082   Ensembl: ENSG000001436217   OMIM: 6031815   UniProtKB: Q129053   

Export aliases for ILF2 gene to outside databases

Previous GC identifers: GC01M151483 GC01M149365 GC01M150409 GC01M150851 GC01M150447 GC01M151900 GC01M124997


Summaries
for ILF2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ILF2:
The protein encoded by this gene is the 45 kDa component of nuclear factor of activated T-cells (NFAT), a heterodimer
of 45 kDa and 90 kDa proteins. NFAT is a transcription factor required for T-cell expression of the interleukin 2
gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral
polymerase. The complex has been shown to repair DNA breaks by nonhomologous end joining and can also negatively
regulate the microRNA processing pathway. Alternative splicing results in multiple transcript variants. Related
pseudogenes have been found on chromosomes 3 and 14. (provided by RefSeq, Jun 2012)

UniProtKB/Swiss-Prot: ILF2_HUMAN, Q12905
Function: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate
transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent
protein kinase holoenzyme complexes on DNA

Gene Wiki entry for ILF2


Genomic Views
for ILF2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ILF2 gene promoter:
         E2F-4   E2F-3a   NF-1/L   E2F-5   E2F-2   GATA-1   E2F-1   E2F   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ILF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ILF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ILF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

ILF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ILF2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153634:  view genomic region     (about GC identifiers)

Start:
 153,634,512 bp from pter      End:
 153,643,524 bp from pter
Size:
 9,013 bases      Orientation:
 minus strand

Proteins
for ILF2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ILF2_HUMAN, Q12905 (See protein sequence)
Recommended Name: Interleukin enhancer-binding factor 2  
Size: 390 amino acids; 43062 Da
Subunit: Forms heterodimers with ILF3. ILF2-ILF3 heterodimers may also bind to PRKDC/XRCC7: this may stabilize the
interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80. Forms a complex with ILF3,
YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9,
ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL,
PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts
with IGF2BP1
Subcellular location: Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing
untranslated mRNAs
Sequence caution: Sequence=AAA20993.1; Type=Frameshift; Positions=376; Sequence=AAF29591.1; Type=Miscellaneous
discrepancy; Note=Chimeric cDNA; Sequence=CAI13611.1; Type=Erroneous gene model prediction;
Secondary accessions: A6NDB0 B2R8G7 Q5SR10 Q5SR11 Q7L7R3 Q9BWD4 Q9P1N0

Explore the universe of human proteins at neXtProt for ILF2: NX_Q12905

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q12905

    • ILF2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001254738.1  NP_004506.2  

    ENSEMBL proteins: 
     ENSP00000355011   ENSP00000357673   ENSP00000357670  

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    Novus Biologicals ILF2 Proteins
    Novus Biologicals ILF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ILF2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0030529ribonucleoprotein complex IDA17289661


    ILF2 for ontologies           About GeneDecksing



    ILF2 Antibody Products: 
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    Uscn ELISAs and CLIAs for ILF2

    Protein Domains /
    Families
    for ILF2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ILF2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR006116 2-5-oligoadenylate_synth_N
     IPR006561 DZF

    Graphical View of Domain Structure for InterPro Entry Q12905

    ProtoNet protein and cluster: Q12905

    UniProtKB/Swiss-Prot: ILF2_HUMAN, Q12905
    Similarity: Contains 1 DZF domain


    Function
    for ILF2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ILF2_HUMAN, Q12905
    Function: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate
    transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent
    protein kinase holoenzyme complexes on DNA

    miRNA
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    hsa-miR-513b hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmid: ILF2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ILF2 (see all 7)
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA11804788
    GO:0003725double-stranded RNA binding IDA10574923
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0016740transferase activity IEA--


    ILF2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ILF2:
     Decreased melanin production  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Ilf2tm1Pnk for ILF2
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ilf2):
     immune system  mortality/aging 

    ILF2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ILF2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ILF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1035 Interacting proteins for ILF2 (Q129051, 2, 3 ENSP000003550114) via UniProtKB, MINT, STRING, and/or I2D (see all 1035)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ILF3Q129062, 3, ENSP000004041214MINT-8076150 MINT-8076195 MINT-6488791 MINT-8076167 MINT-7945693 MINT-8076181 MINT-8076071 MINT-8076347 MINT-8076236 I2D: score=2 STRING: ENSP00000404121
    RAD50Q928782, ENSP000002653354MINT-8076150 MINT-8076195 MINT-7947479 MINT-8076209 MINT-7945693 MINT-8076167 MINT-8076181 MINT-8076071 MINT-8076347 MINT-8076236 STRING: ENSP00000265335
    EEF1A1P681042, ENSP000003300544MINT-6489539 MINT-6488590 MINT-7947479 MINT-6488791 MINT-7945693 MINT-6489355 MINT-8076071 MINT-8076347 MINT-8076236 STRING: ENSP00000330054
    SF3A2Q154282, 3, ENSP000002214944MINT-5206232 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    NFKB2Q006532, 3, ENSP000001894444MINT-48700 I2D: score=2 STRING: ENSP00000189444
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IDA11739746
    GO:0006955immune response IEA--
    GO:0045893positive regulation of transcription, DNA-dependent IDA11739746


    ILF2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ILF2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ILF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ILF2
    3 Novoseek chemical compound relationships for ILF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nf 45 99.5 85 16533607 (8), 18458058 (7), 17942973 (7), 15817156 (6) (see all 19)
    tacrolimus 41.6 2 7519613 (2)
    cyclosporin a 34.3 2 7519613 (2)

    Search CenterWatch for drugs/clinical trials and news about ILF2 

    Transcripts
    for ILF2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ILF2 gene (2 alternative transcripts): 
    NM_001267809.1  NM_004515.3  

    Unigene Cluster for ILF2:

    Interleukin enhancer binding factor 2, 45kDa
    Hs.75117  [show with all ESTs]
    Unigene Representative Sequence: NM_001267809
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361891(uc001fcr.3 uc010pdy.2 uc009wol.1) ENST00000480213
    ENST00000368684 ENST00000368681

    miRNA
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    hsa-miR-513b hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmid: ILF2 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ILF2
    Clone
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    GenScript: all cDNA clones in your preferred vector: ILF2 (NM_004515)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ILF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ILF2

    Additional cDNA sequence: 

    AK223326.1 AK302214.1 AK313364.1 BC000382.2 HQ322261.1 HQ322262.1 U10323.1 

    24/40 DOTS entries (see all 40):

    DT.97862522  DT.91794779  DT.100860717  DT.91854541  DT.100684382  DT.95294855  DT.100835596  DT.100678194 
    DT.87018008  DT.100831620  DT.121394402  DT.100804456  DT.100767566  DT.121394386  DT.95294905  DT.95294910 
    DT.91920385  DT.100651106  DT.121394334  DT.91794832  DT.95294862  DT.95294904  DT.121394371  DT.95294914 

    24/997 AceView cDNA sequences (see all 997):

    BQ019556 AU118468 CR623082 AA789196 BP366761 W72819 AI910075 AA310546 
    CN482956 Z39284 BE792464 BU156721 BX442380 CR620610 BX420469 AA348936 
    AA314697 CR606686 CR616375 BX459895 AW090776 CF541321 BX382806 BQ650749 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ILF2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                -           -           -           -     -           -           -                 -                                 
    SP2:                                -           -           -           -     -                                                                           
    SP3:                                            -           -           -     -           -           -     -           -                                 
    SP4:                                            -           -                                                                                             
    SP5:                                -           -           -                                                                                             


    ECgene alternative splicing isoforms for ILF2

    Expression
    for ILF2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ILF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGACAGACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ILF2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungLung BudLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ILF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ILF2

    SOURCE GeneReport for Unigene cluster: Hs.75117
        SABiosciences Custom PCR Arrays for ILF2
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    In Situ
    Assay Products:     
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    Orthologs
    for ILF2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ILF2 gene from 5/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ILF21 interleukin enhancer binding factor 2, 45kDa 80.17(n)
    95.9(a)    		   425709  XM_423437.3  XP_423437.3 
    African clawed frog
    (Xenopus laevis)    		 Amphibia ilf2-prov2 interleukin enhancer binding factor 2, 45kDa 75.87(n)    BC043981.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb34h012 Danio rerio cDNA clone MGC73084 IMAGE4199523, complete more 78.61(n)    BC059456.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG56411 , 3 CG56411 58(a)3
    59.29(n)1
    58.07(a)1    		   87B103
    415291  NM_141939.31  NP_650196.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea R11H6.53
    CELE_R11H6.51    		 Human NF45 protein like3
    Protein R11H6.51    		 36(a)3
    45.66(n)1
    38.46(a)1    		   V(14613494-14614750)3
    1799651  NM_074213.31  NP_506614.11 


    ENSEMBL Gene Tree for ILF2 (if available)
    TreeFam Gene Tree for ILF2 (if available) 

    Paralogs
    for ILF2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ILF2 gene
    ZFR22  STRBP2  ILF32  ZFR2  

    ILF2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ILF2
    PGOHUM00000247771 PGOHUM00000238049


    Genomic Variants
    for ILF2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/200 NCBI SNPs in ILF2 are shown (see all 200)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2003981941,2
    		--153633790(+) GCCTAC/TGGACT 5 -- ds5001 nc-transcript-variantut310--------
    rs1997449561,2
    		--153633799(+) CTCAGC/TAGCAC 5 -- ds5001 nc-transcript-variantut310--------
    rs168354891,2
    		C,F,H,--153633803(+) GTAGCA/CCAAGT 5 -- ds5001 nc-transcript-variantut3111Minor allele frequency- C:0.02NA NS EA WA 1350
    rs413050921,2
    		C,--153633810(+) AAGTAC/TTGTTC 5 -- nc-transcript-variantut31 ds50010--------
    rs1166726001,2
    		C,F,--153633819(+) TCCCCA/GGCTGC 5 -- ds5001 ut31 nc-transcript-variant1Minor allele frequency- G:0.04WA 118
    rs2020480141,2
    		C--153633842(-) CTTTGC/TANNNN 5 -- ds5001 nc-transcript-variantut310--------
    rs1891444191,2
    		--153634054(+) GCTGCA/CTACGT 5 -- ds5001 ut31 nc-transcript-variant0--------
    rs73451,2
    		C,F,O,A,H,--153634058(-) CCTCAA/CGTATG 5 -- ut31 nc-transcript-variantds500141Minor allele frequency- C:0.33MN EA NA NS WA CSA 3943
    rs1413525281,2
    		--153634193(+) TGGAGA/GGGGCA 5 -- ds5001 ut31 nc-transcript-variant0--------
    rs784411541,2
    		C,--153634253(+) GGCTTA/GAATAC 5 -- ut31 nc-transcript-variantds50010--------

    HapMap Linkage Disequilibrium report for ILF2 (153634512 - 153643524 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ILF2: --

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    Disorders / Diseases
    for ILF2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ILF2 for disorders           About GeneDecksing

    OMIM gene information: 603181    OMIM disorders: --

    7 diseases for ILF2:    About MalaCards
    pthirus pubis infestation    hepatitis b    hepatitis    treacher collins syndrome
    hepatitis c    hepatocellular carcinoma    carcinoma

    1 disease from the University of Copenhagen DISEASES database for ILF2:
    Pthirus pubis infestation
    Human Genome Epidemiology (HuGE) Navigator: ILF2 (1 document)

    Export disorders for ILF2 gene to outside databases

    Publications
    for ILF2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ILF2 gene, integrated from 9 sources (see all 79):
    (articles sorted by number of sources associating them with ILF2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. (PubMed id 7519613)1, 2, 3, 9 Kao P.N.... Corthesy B. (1994)
    2. DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. (PubMed id 9442054)1, 2, 9 Ting N.S.Y.... Lees-Miller S.P. (1998)
    3. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    7. The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells. (PubMed id 11739746)1, 2 Reichman T.W.... Mathews M.B. (2002)
    8. Directed proteomic analysis of the human nucleolus. (PubMed id 11790298)1, 2 Andersen J.S.... Lamond A.I. (2002)
    9. Autoantibodies define a family of proteins with conserved double- stranded RNA-binding domains as well as DNA binding activity. (PubMed id 10574923)1, 2 Satoh M.... Reeves W.H. (1999)
    10. Nuclear factor 45 (NF45) is a regulatory subunit of complexes with NF90/110 involved in mitotic control. (PubMed id 18458058)1, 9 Guan D....Mathews M.B. (2008)

    External Searches for ILF2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing ILF2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3608 HGNC: 6037 AceView: ILF2 Ensembl:ENSG00000143621 euGenes: HUgn3608
    ECgene: ILF2 H-InvDB: ILF2

    Other Databases showing ILF2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ILF2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ILF2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ILF2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ILF2 gene:
    Search GeneIP for patents involving ILF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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