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Aliases for IL9R Gene

Aliases for IL9R Gene

  • Interleukin 9 Receptor 2 3 5
  • IL-9 Receptor 3 4
  • IL-9R 3 4
  • Interleukin-9 Receptor 3
  • CD129 Antigen 4
  • CD129 3

External Ids for IL9R Gene

Previous GeneCards Identifiers for IL9R Gene

  • GC0XP149216
  • GC0XP151533
  • GC0XP152600
  • GC0XP153659
  • GC0YP057668
  • GC0XP154790
  • GC0XP155227
  • GC0XP143710

Summaries for IL9R Gene

Entrez Gene Summary for IL9R Gene

  • The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL9R Gene

IL9R (Interleukin 9 Receptor) is a Protein Coding gene. Diseases associated with IL9R include Asthma. Among its related pathways are PEDF Induced Signaling and Jak-STAT signaling pathway. GO annotations related to this gene include interleukin-9 receptor activity and interleukin-9 binding.

UniProtKB/Swiss-Prot for IL9R Gene

  • This is a receptor for interleukin-9.

Gene Wiki entry for IL9R Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL9R Gene

Genomics for IL9R Gene

Regulatory Elements for IL9R Gene

Enhancers for IL9R Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around IL9R on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IL9R gene promoter:

Genomic Location for IL9R Gene

Chromosome:
X
Start:
155,997,336 bp from pter
End:
156,011,349 bp from pter
Size:
14,014 bases
Orientation:
Plus strand

Genomic View for IL9R Gene

Genes around IL9R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL9R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL9R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL9R Gene

Proteins for IL9R Gene

  • Protein details for IL9R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01113-IL9R_HUMAN
    Recommended name:
    Interleukin-9 receptor
    Protein Accession:
    Q01113
    Secondary Accessions:
    • B9ZVT0
    • Q14634
    • Q8WWU1
    • Q96TF0

    Protein attributes for IL9R Gene

    Size:
    521 amino acids
    Molecular mass:
    57147 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.
    SequenceCaution:
    • Sequence=AAB30844.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for IL9R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL9R Gene

Post-translational modifications for IL9R Gene

  • Ubiquitination at Lys 94, Lys 187, Lys 19, and Lys 48
  • Glycosylation at Asn 117 and Asn 156
  • Modification sites at PhosphoSitePlus

Other Protein References for IL9R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IL9R

No data available for DME Specific Peptides for IL9R Gene

Domains & Families for IL9R Gene

Protein Domains for IL9R Gene

Suggested Antigen Peptide Sequences for IL9R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01113

UniProtKB/Swiss-Prot:

IL9R_HUMAN :
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 4 subfamily.
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
  • Contains 1 fibronectin type-III domain.
Family:
  • Belongs to the type I cytokine receptor family. Type 4 subfamily.
genes like me logo Genes that share domains with IL9R: view

Function for IL9R Gene

Molecular function for IL9R Gene

GENATLAS Biochemistry:
interleukin 9 receptor,X-linked,escaping X inactivation,subtelomeric long arm pseudoautosomal region (PARXQ),with several alternatively spliced forms
UniProtKB/Swiss-Prot Function:
This is a receptor for interleukin-9.

Gene Ontology (GO) - Molecular Function for IL9R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004919 interleukin-9 receptor activity TAS 1376929
GO:0019983 interleukin-9 binding IEA --
genes like me logo Genes that share ontologies with IL9R: view
genes like me logo Genes that share phenotypes with IL9R: view

Animal Models for IL9R Gene

MGI Knock Outs for IL9R:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IL9R Gene

Localization for IL9R Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL9R Gene

Cell membrane; Single-pass type I membrane protein. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL9R Gene COMPARTMENTS Subcellular localization image for IL9R gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for IL9R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 1376929
GO:0005887 integral component of plasma membrane TAS 1376929
genes like me logo Genes that share ontologies with IL9R: view

Pathways & Interactions for IL9R Gene

genes like me logo Genes that share pathways with IL9R: view

SIGNOR curated interactions for IL9R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL9R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 1376929
GO:0008283 cell proliferation TAS 1376929
GO:0030307 positive regulation of cell growth IEA --
GO:0038113 interleukin-9-mediated signaling pathway IEA --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with IL9R: view

Drugs & Compounds for IL9R Gene

(1) Additional Compounds for IL9R Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL9R: view

Transcripts for IL9R Gene

Unigene Clusters for IL9R Gene

Interleukin 9 receptor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL9R Gene

No ASD Table

Relevant External Links for IL9R Gene

GeneLoc Exon Structure for
IL9R
ECgene alternative splicing isoforms for
IL9R

Expression for IL9R Gene

mRNA expression in normal human tissues for IL9R Gene

NURSA nuclear receptor signaling pathways regulating expression of IL9R Gene:

IL9R

SOURCE GeneReport for Unigene cluster for IL9R Gene:

Hs.406228
genes like me logo Genes that share expression patterns with IL9R: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IL9R Gene

Orthologs for IL9R Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL9R Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL9R 34
  • 74.4 (n)
  • 65.2 (a)
IL9R 35
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL9R 34
  • 78.35 (n)
  • 65.56 (a)
IL9R 35
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il9r 34
  • 74.4 (n)
  • 61.38 (a)
Il9r 16
Il9r 35
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il9r 34
  • 72.41 (n)
  • 58.61 (a)
oppossum
(Monodelphis domestica)
Mammalia IL9R 35
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL9R 35
  • 40 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL9R 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL9R 34
  • 51 (n)
  • 36.94 (a)
IL9R 35
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL9R 35
  • 30 (a)
OneToOne
Species where no ortholog for IL9R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL9R Gene

ENSEMBL:
Gene Tree for IL9R (if available)
TreeFam:
Gene Tree for IL9R (if available)

Paralogs for IL9R Gene

genes like me logo Genes that share paralogs with IL9R: view

No data available for Paralogs for IL9R Gene

Variants for IL9R Gene

Sequence variations from dbSNP and Humsavar for IL9R Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_014804 -
VAR_033920 -
VAR_038784 -
VAR_055348 -
VAR_055349 -

Structural Variations from Database of Genomic Variants (DGV) for IL9R Gene

Variant ID Type Subtype PubMed ID
esv22690 CNV loss 19812545
nsv1110654 CNV duplication 24896259
nsv1125165 CNV duplication 24896259
nsv1150813 CNV duplication 26484159

Variation tolerance for IL9R Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.91; 74.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL9R Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL9R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL9R Gene

Disorders for IL9R Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL9R Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards
Search IL9R in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL9R

Genetic Association Database (GAD)
IL9R
Human Genome Epidemiology (HuGE) Navigator
IL9R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL9R
genes like me logo Genes that share disorders with IL9R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL9R Gene

Publications for IL9R Gene

  1. The IL-9 receptor gene (IL9R): genomic structure, chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes, and identification of IL9R pseudogenes at 9qter, 10pter, 16pter, and 18pter. (PMID: 8666384) Kermouni A. … Renauld J.-C. (Genomics 1995) 2 3 4 22 65
  2. The IL9R region contribution in asthma is supported by genetic association in an isolated population. (PMID: 11039580) Kauppi P. … Kere J. (Eur. J. Hum. Genet. 2000) 3 22 46 65
  3. Expression cloning of the murine and human interleukin 9 receptor cDNAs. (PMID: 1376929) Renauld J.-C. … van Snick J. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 65
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 65
  5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 46 65

Products for IL9R Gene

Sources for IL9R Gene

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