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Aliases for IL9 Gene

Aliases for IL9 Gene

  • Interleukin 9 2 3
  • T-Cell Growth Factor P40 2 3 4
  • Homolog Of Mouse T Cell And Mast Cell Growth Factor 40 2 3
  • P40 T-Cell And Mast Cell Growth Factor 2 3
  • P40 Cytokine 2 3
  • Cytokine P40 3 4
  • IL-9 3 4
  • Interleukin-9 3
  • HP40 3
  • P40 3

External Ids for IL9 Gene

Summaries for IL9 Gene

Entrez Gene Summary for IL9 Gene

  • The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL9 Gene

IL9 (Interleukin 9) is a Protein Coding gene. Diseases associated with IL9 include asthma and bronchitis. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and interleukin-9 receptor binding.

UniProtKB/Swiss-Prot for IL9 Gene

  • Supports IL-2 independent and IL-4 independent growth of helper T-cells

Gene Wiki entry for IL9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL9 Gene

Genomics for IL9 Gene

Genomic Location for IL9 Gene

Start:
135,892,246 bp from pter
End:
135,895,827 bp from pter
Size:
3,582 bases
Orientation:
Minus strand

Genomic View for IL9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL9 Gene

Regulatory Elements for IL9 Gene

Proteins for IL9 Gene

  • Protein details for IL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15248-IL9_HUMAN
    Recommended name:
    Interleukin-9
    Protein Accession:
    P15248
    Secondary Accessions:

    Protein attributes for IL9 Gene

    Size:
    144 amino acids
    Molecular mass:
    15909 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL9 Gene

Proteomics data for IL9 Gene at MOPED

Post-translational modifications for IL9 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn50, Asn63, Asn78, and Asn114

Other Protein References for IL9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL9 Gene

Domains for IL9 Gene

Gene Families for IL9 Gene

HGNC:
  • IL :Interleukins and interleukin receptors

Protein Domains for IL9 Gene

UniProtKB/Swiss-Prot:

IL9_HUMAN
Family:
  • Belongs to the IL-7/IL-9 family.:
    • P15248
genes like me logo Genes that share domains with IL9: view

Function for IL9 Gene

Molecular function for IL9 Gene

GENATLAS Biochemistry: interleukin 9,mouse T cell growth factor P40 homolog,determining factor in controlling bronchial hyperresponsiveness
UniProtKB/Swiss-Prot Function: Supports IL-2 independent and IL-4 independent growth of helper T-cells

Gene Ontology (GO) - Molecular Function for IL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005126 cytokine receptor binding --
GO:0005140 interleukin-9 receptor binding IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with IL9: view
genes like me logo Genes that share phenotypes with IL9: view

Animal Models for IL9 Gene

MGI Knock Outs for IL9:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IL9 Gene

Localization for IL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL9 Gene COMPARTMENTS Subcellular localization image for IL9 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for IL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL9: view

Pathways for IL9 Gene

genes like me logo Genes that share pathways with IL9: view

Pathways by source for IL9 Gene

Gene Ontology (GO) - Biological Process for IL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 9371819
GO:0006955 immune response IEA --
GO:0008284 positive regulation of cell proliferation TAS 1680606
GO:0030307 positive regulation of cell growth IEA --
GO:0045407 positive regulation of interleukin-5 biosynthetic process ISS --
genes like me logo Genes that share ontologies with IL9: view

Compounds for IL9 Gene

(23) Novoseek inferred chemical compound relationships for IL9 Gene

Compound -log(P) Hits PubMed IDs
rantes 63.2 11
acridine orange 61.4 1
[alcl] 56.7 6
methylcellulose 42 2
tyrosine 41.9 31
genes like me logo Genes that share compounds with IL9: view

Transcripts for IL9 Gene

mRNA/cDNA for IL9 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL9 Gene

Interleukin 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL9 Gene

No ASD Table

Relevant External Links for IL9 Gene

GeneLoc Exon Structure for
IL9
ECgene alternative splicing isoforms for
IL9

Expression for IL9 Gene

mRNA expression in normal human tissues for IL9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL9 Gene

This gene is overexpressed in Nerve - Tibial (17.9), Brain - Hippocampus (5.2), and Brain - Cortex (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL9 Gene

SOURCE GeneReport for Unigene cluster for IL9 Gene Hs.960

genes like me logo Genes that share expressions with IL9: view

Orthologs for IL9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL9 36
  • 99.54 (n)
  • 99.31 (a)
IL9 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL9 36
  • 72.9 (n)
  • 58.99 (a)
IL9 37
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL9 36
  • 76.3 (n)
  • 65.93 (a)
mouse
(Mus musculus)
Mammalia Il9 36
  • 69 (n)
  • 56.64 (a)
Il9 16
Il9 37
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL9 37
  • 29 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il9 36
  • 70.16 (n)
  • 58.04 (a)
Species with no ortholog for IL9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL9 Gene

ENSEMBL:
Gene Tree for IL9 (if available)
TreeFam:
Gene Tree for IL9 (if available)

Paralogs for IL9 Gene

Pseudogenes.org Pseudogenes for IL9 Gene

genes like me logo Genes that share paralogs with IL9: view

No data available for Paralogs for IL9 Gene

Variants for IL9 Gene

Sequence variations from dbSNP and Humsavar for IL9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs31564 -- 135,894,564(-) AGTAC(A/C)GTCCA intron-variant
rs1799962 -- 135,896,167(-) AGGGA(A/C/G)AATAC upstream-variant-2KB
rs1859430 -- 135,894,824(-) CACTA(C/T)GGCAG intron-variant
rs2066758 -- 135,895,506(-) TTCAC(A/G)TCTGG intron-variant
rs2066760 -- 135,895,458(-) TGTCT(A/C)TGTTT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for IL9 Gene

Variant ID Type Subtype PubMed ID
dgv1853e1 CNV Complex 17122850

Relevant External Links for IL9 Gene

HapMap Linkage Disequilibrium report
IL9
Human Gene Mutation Database (HGMD)
IL9

Disorders for IL9 Gene

(1) University of Copenhagen DISEASES for IL9 Gene

(49) Novoseek inferred disease relationships for IL9 Gene

Disease -log(P) Hits PubMed IDs
severe combined immunodeficiency, x-linked 90.3 17
asthma 61.9 65
asthma allergic 57.9 9
severe combined immunodeficiency 54.1 1
atopy 51.1 9

Relevant External Links for IL9

Genetic Association Database (GAD)
IL9
Human Genome Epidemiology (HuGE) Navigator
IL9
genes like me logo Genes that share disorders with IL9: view

No data available for UniProtKB/Swiss-Prot for IL9 Gene

Publications for IL9 Gene

  1. Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene. (PMID: 1971295) Renauld J.-C. … van Snick J. (J. Immunol. 1990) 3 4 23
  2. Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells. (PMID: 1901233) Kelleher K. … Yang Y.C. (Blood 1991) 3 4 23
  3. Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-alpha genes on respiratory syncytial virus bronchiolitis. (PMID: 14722888) Hoebee B. … Kimman T.G. (J. Infect. Dis. 2004) 3 23 49
  4. The synergistic effects of the IL-9 gene and environmental exposures on asthmatic Taiwanese families as determined by the transmission/disequilibrium test. (PMID: 16611254) Wang T.N. … Ko Y.C. (Int. J. Immunogenet. 2006) 3 23 49
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A. … Janssen R. (Pediatr. Pulmonol. 2010) 3 23 49

Products for IL9 Gene

Sources for IL9 Gene

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