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IL9 Gene

protein-coding   GIFtS: 64
GCID: GC05M135227

Interleukin 9

  See IL9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 91 2     Cytokine P402 3
T-Cell Growth Factor P401 2 3     IL-92 3
Homolog Of Mouse T Cell And Mast Cell Growth Factor 401 2     HP402
P40 Cytokine1 2     P402
P40 T-Cell And Mast Cell Growth Factor1 2     interleukin-92

External Ids:    HGNC: 60291   Entrez Gene: 35782   Ensembl: ENSG000001458397   OMIM: 1469315   UniProtKB: P152483   

Export aliases for IL9 gene to outside databases

Previous GC identifers: GC05M135103 GC05M135891 GC05M135258 GC05M135304 GC05M135255 GC05M130416


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL9 Gene:
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This
cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor
(IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine
to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for
asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the
pathogenesis of bronchial hyperresponsiveness. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL9 Gene:
IL9 (interleukin 9) is a protein-coding gene. Diseases associated with IL9 include bronchitis, and tetanus. GO annotations related to this gene include cytokine activity and interleukin-9 receptor binding.

UniProtKB/Swiss-Prot: IL9_HUMAN, P15248
Function: Supports IL-2 independent and IL-4 independent growth of helper T-cells

Gene Wiki entry for IL9 (Interleukin 9) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL9 gene promoter:
         STAT1   STAT4   STAT1beta   STAT5A   IRF-1   STAT1alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL9 promoter sequence
   Search Chromatin IP Primers for IL9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31-q35

IL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL9 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M135227:  view genomic region     (about GC identifiers)

Start:
135,227,935 bp from pter      End:
135,231,516 bp from pter
Size:
3,582 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IL9_HUMAN, P15248 (See protein sequence)
Recommended Name: Interleukin-9 precursor  
Size: 144 amino acids; 15909 Da

Explore the universe of human proteins at neXtProt for IL9: NX_P15248

Explore proteomics data for IL9 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn50, Asn63, Asn78, Asn114
  • Modification sites at PhosphoSitePlus

  • See IL9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000581.1  
    ENSEMBL proteins: 
     ENSP00000274520  

    IL9 Human Recombinant Protein Products:

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    Novus Biologicals IL9 Proteins
    Novus Biologicals IL9 Lysates
    Sino Biological Recombinant Protein for IL9
    Sino Biological Cell Lysate for IL9
    ProSpec Recombinant Protein for IL9
    Cloud-Clone Corp. Proteins for IL9

     
    eBioscience Proteins for IL9: (see all 2
                        Human IL-9 Recombinant Protein 5 ug

     
    antibodies-online proteins for IL9 (60 products) 

     
    antibodies-online peptides for IL9

    IL9 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for IL9 (85 products) 

    IL9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL9
    Cloud-Clone Corp. CLIAs for IL9
    eBioscience ELISAs for IL9: (see all 2
                        Human IL-9 Platinum ELISA 96 tests
    antibodies-online kits for IL9 (37 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    3 InterPro protein domains:
     IPR000226 IL-7/IL-9_fam
     IPR018049 IL-7/IL-9_CS
     IPR020447 IL-9

    Graphical View of Domain Structure for InterPro Entry P15248

    ProtoNet protein and cluster: P15248

    1 Blocks protein domain: IPB000226 Interleukin-7/interleukin-9

    UniProtKB/Swiss-Prot: IL9_HUMAN, P15248
    Similarity: Belongs to the IL-7/IL-9 family


    Find genes that share domains with IL9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL9_HUMAN, P15248
    Function: Supports IL-2 independent and IL-4 independent growth of helper T-cells

         Genatlas biochemistry entry for IL9:
    interleukin 9,mouse T cell growth factor P40 homolog,determining factor in controlling bronchial
    hyperresponsiveness

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005126cytokine receptor binding ----
    GO:0005140interleukin-9 receptor binding IEA--
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with IL9           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il9):
     digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with IL9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il9tm1Anjm for IL9

       genOway: Develop your customized and physiologically relevant rodent model for IL9

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat IL9 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IL9:
    hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL9
    Predesigned siRNA for gene silencing in human, mouse, rat IL9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL9

    Clone
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    GenScript: all cDNA clones in your preferred vector: IL9 (NM_000590)
    Sino Biological Human cDNA Clone for IL9
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL9

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL9_HUMAN, P15248: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IL9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL9 About   (see all 20)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    Immune response IL 9 signaling pathway0.42
    IL-9 Signaling Pathway0.42
    IL-9 Pathway0.36
    2PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40


    Find genes that share SuperPaths with IL9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IL9
        IL-9 Signaling Pathways
    IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL9 (see all 70)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for IL9
        Immune response IL-9 signaling pathway

    2 BioSystems Pathways for IL9
        IL-9 Signaling Pathway
    TCR Signaling Pathway



    3 Kegg Pathways  (Kegg details for IL9):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Asthma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL9 (see all 10): 
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th17 Response in human mouse rat
              Th1/Th2 Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for IL9 (P152483 ENSP000002745204) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL9RQ011133, ENSP000002441744I2D: score=2 STRING: ENSP00000244174
    IL2RGP317853I2D: score=1 
    SNTA1Q134243I2D: score=1 
    CSF2ENSP000002968714STRING: ENSP00000296871
    IL13ENSP000003049154STRING: ENSP00000304915
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response TAS9371819
    GO:0006955immune response IEA--
    GO:0008284positive regulation of cell proliferation TAS1680606
    GO:0030307positive regulation of cell growth IEA--
    GO:0045407positive regulation of interleukin-5 biosynthetic process ISS--

    Find genes that share ontologies with IL9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL9

    Selected Novoseek inferred chemical compound relationships for IL9 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 63.2 12 11588013 (2), 18489763 (1), 18703348 (1), 11675352 (1) (see all 10)
    acridine orange 61.4 1 8611712 (1)
    [alcl] 56.7 9 16763206 (3), 16888916 (1), 12555065 (1), 11217440 (1)
    methylcellulose 42 2 8611712 (1), 12646606 (1)
    tyrosine 41.9 42 7756643 (6), 1382699 (6), 7929391 (4), 9923452 (3) (see all 14)
    allergens 41 6 16433854 (2), 9590218 (1), 14641603 (1), 11703216 (1) (see all 5)
    c-d4t 39 1 12470268 (1)
    niflumic acid 36.9 1 17250694 (1)
    tarc 32.9 2 15294996 (2)
    chloride 17.2 10 11842292 (2), 12782818 (2), 20525149 (2), 19907312 (1) (see all 6)



    Find genes that share compounds with IL9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL9 gene: 
    NM_000590.1  

    Unigene Cluster for IL9:

    Interleukin 9
    Hs.960  [show with all ESTs]
    Unigene Representative Sequence: BG398985
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000274520(uc003lbb.1)
    miRNA
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    hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL9 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat IL9
      QuantiFast Probe-based Assays in human, mouse, rat IL9

    Additional mRNA sequence: 

    BC066283.1 BC066284.1 BC066285.1 BC066286.1 BC066287.1 M30134.1 S63356.1 X17543.1 

    2 DOTS entries:

    DT.109716  DT.91970267 

    16 AceView cDNA sequences:

    BC066286 CD559733 BC066285 S63356 M30134 NM_000590 X17543 BC066283 
    CD559578 BC066287 CD559580 BC066284 CD559576 CD559577 CD559732 CD559579 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAACAAGAT
    IL9 Expression
    About this image


    IL9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
    IL9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.960
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL9 (see all 10): 
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th17 Response in human mouse rat
              Th1/Th2 Response in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat IL9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL9 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il91 , 5 interleukin 91, 5 69(n)1
    56.64(a)1
      13 (30.06 cM)5
    161981  NM_008373.11  NP_032399.11 
     564792775 


    ENSEMBL Gene Tree for IL9 (if available)
    TreeFam Gene Tree for IL9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL9 gene

    Find genes that share paralogs with IL9           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IL9
    PGOHUM00000246000


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL9 (see all 143)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs798861921,2
    C,F--135227499(+) CATAAT/CAATAA 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1860624341,2
    --135227616(+) CCTCTC/TTCAGG 1 -- ds50010--------
    rs20698861,2
    C,F,H--135227791(-) CTGATG/ACTGAA 1 -- ds50017Minor allele frequency- A:0.01NS EA CSA 504
    rs1910105301,2
    --135227872(+) TTTGTG/TCTGAG 1 -- ds50010--------
    rs1813240571,2
    --135228061(+) AATAGA/GATAAA 1 -- ut310--------
    rs1401156921,2
    C,F--135228138(+) GACTCT/GTCAGA 2 /K /T mis12Minor allele frequency- G:0.00NA EU 5863
    rs1412191531,2
    C--135228152(+) GTCAGC/TGCGTT 2 A syn10--------
    rs2001280041,2
    --135228161(+) TTGCCC/TGCCGT 2 A syn10--------
    rs20698851,2,,4
    C,F,O,H--135228165(-) AACCAC/TGGCAG 2 T M mis1 ese330Minor allele frequency- T:0.12NS NA EA WA CSA EU 8751
    rs1168960491,2
    C,F--135228268(+) AAGCCT/AACCTG 1 -- int11Minor allele frequency- A:0.04EA 120

    HapMap Linkage Disequilibrium report for IL9 (135227935 - 135231516 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL9:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1853e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): IL9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL9
    DNA2.0 Custom Variant and Variant Library Synthesis for IL9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146931    OMIM disorders: --

    14 diseases for IL9:    
    About MalaCards
    bronchitis    tetanus    retinopathy of prematurity    pulmonary sarcoidosis
    cerebral malaria    castleman's disease    cerebral palsy    atopy
    sarcoidosis    allergic rhinitis    anaplastic large cell lymphoma    asthma
    cystic fibrosis    malaria

    1 disease from the University of Copenhagen DISEASES database for IL9:
    Asthma

    Find genes that share disorders with IL9           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL9 gene (see all 49)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    severe combined immunodeficiency, x-linked 90.3 26 8605322 (1), 14966353 (1), 7481768 (1), 10889304 (1) (see all 17)
    asthma 61.9 78 16611254 (3), 10629460 (3), 10329852 (3), 15007348 (3) (see all 46)
    asthma allergic 57.9 13 10629460 (2), 10984364 (1), 14641603 (1), 12789235 (1) (see all 8)
    severe combined immunodeficiency 54.1 1 14502230 (1)
    atopy 51.1 9 16433854 (3), 10224407 (2), 16611254 (1), 9988446 (1) (see all 6)
    inflammation 47.3 30 9806735 (4), 15133304 (3), 10871433 (3), 11868823 (2) (see all 17)
    lymphoma t-cell 43.4 10 16322282 (3), 9505195 (1), 11115404 (1), 1908723 (1) (see all 6)
    necrosis 43.4 28 14722888 (2), 8952534 (1), 11964741 (1), 8375854 (1) (see all 26)
    hodgkin disease 43.1 8 1908723 (2), 1283279 (1), 9505195 (1), 7858153 (1) (see all 7)
    allergy 42.4 6 12653157 (1), 9042069 (1), 11150594 (1), 12009564 (1) (see all 5)

    Genetic Association Database (GAD): IL9
    Human Genome Epidemiology (HuGE) Navigator: IL9 (37 documents)

    Export disorders for IL9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL9 gene, integrated from 10 sources (see all 485):
    (articles sorted by number of sources associating them with IL9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The synergistic effects of the IL-9 gene and environmental exposures on asthmatic Taiwanese families as determined by the transmission/disequilibrium test. (PubMed id 16611254)1, 4, 9 Wang T.N....Ko Y.C. (Int. J. Immunogenet. 2006)
    2. Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells. (PubMed id 1901233)1, 2, 9 Kelleher K.... Yang Y.C. (Blood 1991)
    3. Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene. (PubMed id 1971295)1, 2, 9 Renauld J.-C....van Snick J. (J. Immunol. 1990)
    4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4, 9 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    5. Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-alpha genes on respiratory syncytial virus bronchiolitis. (PubMed id 14722888)1, 4, 9 Hoebee B....Kimman T.G. (J. Infect. Dis. 2004)
    6. Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitization. (PubMed id 20595916)1, 4 McCanlies E.C....Weston A. (J. Occup. Environ. Med. 2010)
    7. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    10. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3578 HGNC: 6029 AceView: IL9 Ensembl:ENSG00000145839 euGenes: HUgn3578
    ECgene: IL9 Kegg: 3578 H-InvDB: IL9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL9 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_9
    SeattleSNPshttp://pga.gs.washington.edu/data/il9/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL9 gene:
    Search GeneIP for patents involving IL9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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