Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL9 Gene

Aliases for IL9 Gene

  • Interleukin 9 2 3 5
  • T-Cell Growth Factor P40 2 3 4
  • Homolog Of Mouse T Cell And Mast Cell Growth Factor 40 2 3
  • P40 T-Cell And Mast Cell Growth Factor 2 3
  • P40 Cytokine 2 3
  • Cytokine P40 3 4
  • IL-9 3 4
  • Interleukin-9 3
  • HP40 3
  • P40 3

External Ids for IL9 Gene

Previous GeneCards Identifiers for IL9 Gene

  • GC05M135103
  • GC05M135258
  • GC05M135304
  • GC05M135255
  • GC05M130416
  • GC05M135227

Summaries for IL9 Gene

Entrez Gene Summary for IL9 Gene

  • The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL9 Gene

IL9 (Interleukin 9) is a Protein Coding gene. Diseases associated with IL9 include Trichuriasis and Severe Combined Immunodeficiency, X-Linked. Among its related pathways are p70S6K Signaling and PEDF Induced Signaling. GO annotations related to this gene include cytokine activity and cytokine receptor binding.

UniProtKB/Swiss-Prot for IL9 Gene

  • Supports IL-2 independent and IL-4 independent growth of helper T-cells.

Gene Wiki entry for IL9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL9 Gene

Genomics for IL9 Gene

Regulatory Elements for IL9 Gene

Enhancers for IL9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around IL9 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL9 Gene

Chromosome:
5
Start:
135,892,246 bp from pter
End:
135,895,827 bp from pter
Size:
3,582 bases
Orientation:
Minus strand

Genomic View for IL9 Gene

Genes around IL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL9 Gene

Proteins for IL9 Gene

  • Protein details for IL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15248-IL9_HUMAN
    Recommended name:
    Interleukin-9
    Protein Accession:
    P15248

    Protein attributes for IL9 Gene

    Size:
    144 amino acids
    Molecular mass:
    15909 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL9 Gene

Post-translational modifications for IL9 Gene

  • Glycosylation at Asn 50, Asn 63, Asn 78, and Asn 114
  • Modification sites at PhosphoSitePlus

Other Protein References for IL9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IL9

Protein Products

  • Abcam proteins for IL9

No data available for DME Specific Peptides for IL9 Gene

Domains & Families for IL9 Gene

Gene Families for IL9 Gene

Protein Domains for IL9 Gene

Suggested Antigen Peptide Sequences for IL9 Gene

Graphical View of Domain Structure for InterPro Entry

P15248

UniProtKB/Swiss-Prot:

IL9_HUMAN :
  • Belongs to the IL-7/IL-9 family.
Family:
  • Belongs to the IL-7/IL-9 family.
genes like me logo Genes that share domains with IL9: view

Function for IL9 Gene

Molecular function for IL9 Gene

GENATLAS Biochemistry:
interleukin 9,mouse T cell growth factor P40 homolog,determining factor in controlling bronchial hyperresponsiveness
UniProtKB/Swiss-Prot Function:
Supports IL-2 independent and IL-4 independent growth of helper T-cells.

Gene Ontology (GO) - Molecular Function for IL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005140 interleukin-9 receptor binding IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with IL9: view
genes like me logo Genes that share phenotypes with IL9: view

Animal Models for IL9 Gene

MGI Knock Outs for IL9:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IL9 Gene

Localization for IL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL9 Gene COMPARTMENTS Subcellular localization image for IL9 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL9: view

Pathways & Interactions for IL9 Gene

genes like me logo Genes that share pathways with IL9: view

SIGNOR curated interactions for IL9 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 9371819
GO:0006955 immune response IEA --
GO:0008284 positive regulation of cell proliferation TAS 1680606
GO:0030307 positive regulation of cell growth IEA --
GO:0045407 positive regulation of interleukin-5 biosynthetic process IEA,ISS --
genes like me logo Genes that share ontologies with IL9: view

Drugs & Compounds for IL9 Gene

(12) Drugs for IL9 Gene - From: ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s 1 (combination) Pharma 343
MEDI-528 Pharma inhibitor 0

(14) Additional Compounds for IL9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL9: view

Transcripts for IL9 Gene

mRNA/cDNA for IL9 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL9 Gene

Interleukin 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL9 Gene

No ASD Table

Relevant External Links for IL9 Gene

GeneLoc Exon Structure for
IL9
ECgene alternative splicing isoforms for
IL9

Expression for IL9 Gene

mRNA expression in normal human tissues for IL9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL9 Gene

This gene is overexpressed in Nerve - Tibial (x17.9), Brain - Hippocampus (x5.2), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for IL9 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL9 Gene



Protein tissue co-expression partners for IL9 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL9 Gene:

IL9

SOURCE GeneReport for Unigene cluster for IL9 Gene:

Hs.960
genes like me logo Genes that share expression patterns with IL9: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IL9 Gene

Orthologs for IL9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL9 34
  • 72.9 (n)
  • 58.99 (a)
IL9 35
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL9 34
  • 76.3 (n)
  • 65.93 (a)
mouse
(Mus musculus)
Mammalia Il9 34
  • 69 (n)
  • 56.64 (a)
Il9 16
Il9 35
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL9 34
  • 99.54 (n)
  • 99.31 (a)
IL9 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il9 34
  • 70.16 (n)
  • 58.04 (a)
oppossum
(Monodelphis domestica)
Mammalia IL9 35
  • 29 (a)
OneToOne
Species where no ortholog for IL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL9 Gene

ENSEMBL:
Gene Tree for IL9 (if available)
TreeFam:
Gene Tree for IL9 (if available)

Paralogs for IL9 Gene

Pseudogenes.org Pseudogenes for IL9 Gene

genes like me logo Genes that share paralogs with IL9: view

No data available for Paralogs for IL9 Gene

Variants for IL9 Gene

Sequence variations from dbSNP and Humsavar for IL9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2069885 - 135,892,476(-) AACCA(C/T)GGCAG reference, missense
rs1799962 -- 135,896,167(-) AGGGA(A/C/G)AATAC upstream-variant-2KB
rs1859430 -- 135,894,824(-) CACTA(C/T)GGCAG intron-variant
rs2066758 -- 135,895,506(-) TTCAC(A/G)TCTGG intron-variant
rs2066760 -- 135,895,458(-) TGTCT(A/C)TGTTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IL9 Gene

Variant ID Type Subtype PubMed ID
esv2759380 CNV loss 17122850

Variation tolerance for IL9 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL9 Gene

Human Gene Mutation Database (HGMD)
IL9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL9 Gene

Disorders for IL9 Gene

MalaCards: The human disease database

(16) MalaCards diseases for IL9 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
trichuriasis
  • infection by trichuris trichura
severe combined immunodeficiency, x-linked
  • xscid
gamma chain deficiency
  • severe combined immunodeficiency, x-linked
asthma
  • asthma, protection against
myelitis
- elite association - COSMIC cancer census association via MalaCards
Search IL9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL9

Genetic Association Database (GAD)
IL9
Human Genome Epidemiology (HuGE) Navigator
IL9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL9
genes like me logo Genes that share disorders with IL9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL9 Gene

Publications for IL9 Gene

  1. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A. … Janssen R. (Pediatr. Pulmonol. 2010) 3 22 46 65
  2. The synergistic effects of the IL-9 gene and environmental exposures on asthmatic Taiwanese families as determined by the transmission/disequilibrium test. (PMID: 16611254) Wang T.N. … Ko Y.C. (Int. J. Immunogenet. 2006) 3 22 46 65
  3. Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells. (PMID: 1901233) Kelleher K. … Yang Y.C. (Blood 1991) 3 4 22 65
  4. Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene. (PMID: 1971295) Renauld J.-C. … van Snick J. (J. Immunol. 1990) 3 4 22 65
  5. IL-9: basic biology, signaling pathways in CD4+ T cells and implications for autoimmunity. (PMID: 20020328) Li H. … Rostami A. (J Neuroimmune Pharmacol 2010) 3 22 65

Products for IL9 Gene

Sources for IL9 Gene

Content