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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL9 Gene

protein-coding   GIFtS: 65
GCID: GC05M135227

Interleukin 9

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Interleukin 91 2     Cytokine P402 3
T-Cell Growth Factor P401 2 3     IL-92 3
Homolog Of Mouse T Cell And Mast Cell Growth Factor 401 2     HP402
P40 Cytokine1 2     P402
P40 T-Cell And Mast Cell Growth Factor1 2     interleukin-92

External Ids:    HGNC: 60291   Entrez Gene: 35782   Ensembl: ENSG000001458397   OMIM: 1469315   UniProtKB: P152483   
ORGUL members:         
NONCODE14:n340641      

Export aliases for IL9 gene to outside databases

Previous GC identifers: GC05M135103 GC05M135891 GC05M135258 GC05M135304 GC05M135255 GC05M130416


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL9 Gene:
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This
cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor
(IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine
to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for
asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the
pathogenesis of bronchial hyperresponsiveness. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL9 Gene: 
IL9 (interleukin 9) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with IL9 include cerebral malaria, and gamma chain deficiency, and among its related super-pathways are IL-9 Signaling Pathways and MIF Mediated Glucocorticoid Regulation. GO annotations related to this gene include growth factor activity and interleukin-9 receptor binding.

UniProtKB/Swiss-Prot: IL9_HUMAN, P15248
Function: Supports IL-2 independent and IL-4 independent growth of helper T-cells

Gene Wiki entry for IL9 (Interleukin 9) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL9 gene promoter:
         STAT1   STAT4   STAT1beta   STAT5A   IRF-1   STAT1alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL9 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31-q35

IL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL9 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M135227:  view genomic region     (about GC identifiers)

Start:
135,227,935 bp from pter      End:
135,231,516 bp from pter
Size:
3,582 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL9_HUMAN, P15248 (See protein sequence)
Recommended Name: Interleukin-9 precursor  
Size: 144 amino acids; 15909 Da
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for IL9: NX_P15248

Explore proteomics data for IL9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P15248

  • IL9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL9 Protein Expression
    REFSEQ proteins: NP_000581.1  
    ENSEMBL proteins: 
     ENSP00000274520  

    Human Recombinant Protein Products for IL9: 
    EMD Millipore Purified and/or Recombinant IL9 Protein
    R&D Systems Recombinant & Natural Proteins for IL9 (IL-9)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IL9
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IL9
    GenScript Purified and Recombinant Proteins for IL9
    Novus Biologicals IL9 Proteins
    Novus Biologicals IL9 Lysates
    Sino Biological Recombinant Protein for IL9
    Sino Biological Cell Lysate for IL9 
    ProSpec Recombinant Protein for IL9
    Cloud-Clone Corp. Proteins for IL9 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    IL9 for ontologies           About GeneDecksing



    IL9 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IL9 (IL-9)
    OriGene Antibodies for IL9
    OriGene Custom Antibody Services for IL9
    GenScript Custom Superior Antibodies Services for IL9
    Novus Biologicals IL9 Antibodies
    Abcam antibodies for IL9
    Cloud-Clone Corp. Antibodies for IL9 
    ThermoFisher Antibodies for IL9
    LSBio Antibodies in human, mouse, rat for IL9 

    Assay Products for IL9: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL9
    R&D Systems ELISpot Kits & Development Modules for IL9 (IL-9)         (see all)
    GenScript Custom Assay Services for IL9
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL9 
    Cloud-Clone Corp. CLIAs for IL9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    3 InterPro protein domains:
     IPR000226 Interleukin_7_9
     IPR018049 Interleukin-7/-9_CS
     IPR020447 Interleukin-9

    Graphical View of Domain Structure for InterPro Entry P15248

    ProtoNet protein and cluster: P15248

    1 Blocks protein domain: IPB000226 Interleukin-7/interleukin-9

    UniProtKB/Swiss-Prot: IL9_HUMAN, P15248
    Similarity: Belongs to the IL-7/IL-9 family


    IL9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL9_HUMAN, P15248
    Function: Supports IL-2 independent and IL-4 independent growth of helper T-cells

         Genatlas biochemistry entry for IL9:
    interleukin 9,mouse T cell growth factor P40 homolog,determining factor in controlling bronchial
    hyperresponsiveness

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005126cytokine receptor binding ----
    GO:0005140interleukin-9 receptor binding IEA--
    GO:0008083growth factor activity IEA--
         
    IL9 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il9):
     digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 

    IL9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il9tm1Anjm for IL9

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL9 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL9
    1 QIAGEN miScript miRNA Assays for microRNA that regulate IL9:
    hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL9 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL9
    Sirion Biotech Customized adenovirus for overexpression of IL9

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IL9 (see all 6)
    OriGene ORF clones in mouse, rat for IL9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL9 (NM_000590)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL9
    Sirion Biotech Customized lentivirus for stable overexpression of IL9 
                         Customized lentivirus expression plasmids for stable overexpression of IL9 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IL9
    Search LifeMap BioReagents cell lines for IL9
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL9 About   (see all 20)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    IL-9 Signaling Pathways0.90
    Immune response IL-9 signaling pathway0.42
    IL-9 Signaling Pathway0.42
    IL-9 Pathway0.36
    2PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for IL9
        Immune response IL-9 signaling pathway

    2 R&D Systems Pathways for IL9
        IL-9 Signaling Pathways
    IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types

    5/70 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL9 (see all 70)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for IL9
        Immune response IL-9 signaling pathway

    2 BioSystems Pathways for IL9
        TCR Signaling Pathway
    IL-9 Signaling Pathway



    3         Kegg Pathways  (Kegg details for IL9):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Asthma


    IL9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/14 Interacting proteins for IL9 (P152483 ENSP000002745204) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL9RQ011133, ENSP000002441744I2D: score=2 STRING: ENSP00000244174
    IL2RGP317853I2D: score=1 
    SNTA1Q134243I2D: score=1 
    CSF2ENSP000002968714STRING: ENSP00000296871
    IL13ENSP000003049154STRING: ENSP00000304915
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response TAS9371819
    GO:0006955immune response IEA--
    GO:0008284positive regulation of cell proliferation TAS1680606
    GO:0030307positive regulation of cell growth IEA--
    GO:0045407positive regulation of interleukin-5 biosynthetic process ISS--

    IL9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL9

    10/23 Novoseek inferred chemical compound relationships for IL9 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 63.2 12 11588013 (2), 18489763 (1), 18703348 (1), 11675352 (1) (see all 10)
    acridine orange 61.4 1 8611712 (1)
    [alcl] 56.7 9 16763206 (3), 16888916 (1), 12555065 (1), 11217440 (1)
    methylcellulose 42 2 8611712 (1), 12646606 (1)
    tyrosine 41.9 42 7756643 (6), 1382699 (6), 7929391 (4), 9923452 (3) (see all 14)
    allergens 41 6 16433854 (2), 9590218 (1), 14641603 (1), 11703216 (1) (see all 5)
    c-d4t 39 1 12470268 (1)
    niflumic acid 36.9 1 17250694 (1)
    tarc 32.9 2 15294996 (2)
    chloride 17.2 10 11842292 (2), 12782818 (2), 20525149 (2), 19907312 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about IL9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL9 gene: 
    NM_000590.1  

    Unigene Cluster for IL9:

    Interleukin 9
    Hs.960  [show with all ESTs]
    Unigene Representative Sequence: BG398985
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000274520(uc003lbb.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL9
    1 QIAGEN miScript miRNA Assays for microRNA that regulate IL9:
    hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL9 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL9
    Clone
    Products:
         
    OriGene clones in human, mouse for IL9 (see all 6)
    OriGene ORF clones in mouse, rat for IL9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL9 (NM_000590)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL9
    Sirion Biotech Customized lentivirus for stable overexpression of IL9 
                         Customized lentivirus expression plasmids for stable overexpression of IL9 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL9
    OriGene qSTAR qPCR primer pairs in human, mouse for IL9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL9

    Additional mRNA sequence: 

    BC066283.1 BC066284.1 BC066285.1 BC066286.1 BC066287.1 M30134.1 S63356.1 X17543.1 

    2 DOTS entries:

    DT.109716  DT.91970267 

    16 AceView cDNA sequences:

    NM_000590 M30134 CD559733 S63356 BC066286 X17543 BC066283 BC066285 
    CD559580 CD559578 CD559576 CD559577 BC066284 BC066287 CD559732 CD559579 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL9 expression in normal human tissues (normalized intensities)      IL9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAACAAGAT
    IL9 Expression
    About this image


    IL9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Adipose (Muscoskeletal System)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)

    See IL9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL9

    SOURCE GeneReport for Unigene cluster: Hs.960
        SABiosciences Expression via Pathway-Focused PCR Arrays including IL9 (see all 10): 
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th17 Response in human mouse rat
              Th1/Th2 Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL9
    OriGene qSTAR qPCR primer pairs in human, mouse for IL9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL9
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL9 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il91 , 5 interleukin 91, 5 69(n)1
    56.64(a)1
      13 (30.06 cM)5
    161981  NM_008373.11  NP_032399.11 
     564792775 
    chicken
    (Gallus gallus)
    Aves IL96
    interleukin 9 precursor
    28(a)
    1 ↔ 1
    13(14562900-14565599)


    ENSEMBL Gene Tree for IL9 (if available)
    TreeFam Gene Tree for IL9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL9 gene

    IL9 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IL9
    PGOHUM00000246000


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/143 SNPs in IL9 are shown (see all 143)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs798861921,2
    C,F--135227499(+) CATAAT/CAATAA 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1860624341,2
    --135227616(+) CCTCTC/TTCAGG 1 -- ds50010--------
    rs20698861,2
    C,F,H--135227791(-) CTGATG/ACTGAA 1 -- ds50017Minor allele frequency- A:0.01NS EA CSA 504
    rs1910105301,2
    --135227872(+) TTTGTG/TCTGAG 1 -- ds50010--------
    rs1813240571,2
    --135228061(+) AATAGA/GATAAA 1 -- ut310--------
    rs1401156921,2
    C,F--135228138(+) GACTCT/GTCAGA 2 /K /T mis12Minor allele frequency- G:0.00NA EU 5863
    rs1412191531,2
    C--135228152(+) GTCAGC/TGCGTT 2 A syn10--------
    rs2001280041,2
    --135228161(+) TTGCCC/TGCCGT 2 A syn10--------
    rs20698851,2,4
    C,F,O,H--135228165(-) AACCAC/TGGCAG 2 T M mis1 ese330Minor allele frequency- T:0.12NS NA EA WA CSA EU 8751
    rs1168960491,2
    C,F--135228268(+) AAGCCT/AACCTG 1 -- int11Minor allele frequency- A:0.04EA 120

    HapMap Linkage Disequilibrium report for IL9 (135227935 - 135231516 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL9:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1853e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): IL9
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 146931    OMIM disorders: --

    20/56 diseases for IL9 (see all 56):    About MalaCards
    cerebral malaria    gamma chain deficiency    pulmonary sarcoidosis    castleman's disease
    bronchitis    tetanus    retinopathy of prematurity    atopy
    asthma    anaplastic large cell lymphoma    cerebral palsy    trichuriasis
    allergic rhinitis    sarcoidosis    severe combined immunodeficiency    diamond-blackfan anemia
    adult t-cell leukemia    mastocytosis    rhinitis    venous thromboembolism

    1 disease from the University of Copenhagen DISEASES database for IL9:
    Asthma

    IL9 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/49 Novoseek inferred disease relationships for IL9 gene (see all 49)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    severe combined immunodeficiency, x-linked 90.3 26 8605322 (1), 14966353 (1), 7481768 (1), 10889304 (1) (see all 17)
    asthma 61.9 78 16611254 (3), 10629460 (3), 10329852 (3), 15007348 (3) (see all 46)
    asthma allergic 57.9 13 10629460 (2), 10984364 (1), 14641603 (1), 12789235 (1) (see all 8)
    severe combined immunodeficiency 54.1 1 14502230 (1)
    atopy 51.1 9 16433854 (3), 10224407 (2), 16611254 (1), 9988446 (1) (see all 6)
    inflammation 47.3 30 9806735 (4), 15133304 (3), 10871433 (3), 11868823 (2) (see all 17)
    lymphoma t-cell 43.4 10 16322282 (3), 9505195 (1), 11115404 (1), 1908723 (1) (see all 6)
    necrosis 43.4 28 14722888 (2), 8952534 (1), 11964741 (1), 8375854 (1) (see all 26)
    hodgkin disease 43.1 8 1908723 (2), 1283279 (1), 9505195 (1), 7858153 (1) (see all 7)
    allergy 42.4 6 12653157 (1), 9042069 (1), 11150594 (1), 12009564 (1) (see all 5)

    Genetic Association Database (GAD): IL9
    Human Genome Epidemiology (HuGE) Navigator: IL9 (37 documents)

    Export disorders for IL9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL9 gene, integrated from 9 sources (see all 480):
    (articles sorted by number of sources associating them with IL9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The synergistic effects of the IL-9 gene and environmental exposures on asthmatic Taiwanese families as determined by the transmission/disequilibrium test. (PubMed id 16611254)1, 4, 9 Wang T.N....Ko Y.C. (2006)
    2. Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells. (PubMed id 1901233)1, 2, 9 Kelleher K.... Yang Y.C. (1991)
    3. Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene. (PubMed id 1971295)1, 2, 9 Renauld J.-C....van Snick J. (1990)
    4. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4, 9 Schuurhof A....Janssen R. (2010)
    5. Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-alpha genes on respiratory syncytial virus bronchiolitis. (PubMed id 14722888)1, 4, 9 Hoebee B....Kimman T.G. (2004)
    6. Association between IL-1A single nucleotide polymorph isms and chronic beryllium disease and beryllium sensitization. (PubMed id 20595916)1, 4 McCanlies E.C....Weston A. (2010)
    7. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (2010)
    10. A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3578 HGNC: 6029 AceView: IL9 Ensembl:ENSG00000145839 euGenes: HUgn3578
    ECgene: IL9 Kegg: 3578 H-InvDB: IL9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL9 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_9
    SeattleSNPshttp://pga.gs.washington.edu/data/il9/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL9 gene:
    Search GeneIP for patents involving IL9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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