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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL8 Gene

protein-coding   GIFtS: 71
GCID: GC04P074595

interleukin 8
 Explore 434 diseases affiliated with
IL8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IL8    

Aliases
for IL8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interleukin 81 2     K601
CXCL81 2 3     SCYB81
GCP-11 2 3     TSG-11
MDNCF1 2 3     B-ENAP1
MONAP1 2 3     Alveolar Macrophage Chemotactic Factor I2
NAP-11 2 3     Beta Endothelial Cell-Derived Neutrophil Activating Peptide2
GCP11 2     Beta-Thromboglobulin-Like Protein2
LECT1 2     Chemokine (C-X-C Motif) Ligand 82
LUCT1 2     Emoctakin3
LYNAP1 2     Interleukin-81
NAF1 2     Lung Giant Cell Carcinoma-Derived Chemotactic Protein2
NAP11 2     Lymphocyte Derived Neutrophil Activating Peptide2
IL-81 3     Neutrophil-Activating Peptide 12
Granulocyte Chemotactic Protein 12 3     Small Inducible Cytokine Subfamily B, Member 82
Monocyte-Derived Neutrophil Chemotactic Factor2 3     Tumor Necrosis Factor-Induced Gene 12
Monocyte-Derived Neutrophil-Activating Peptide2 3     Emoctakin3
T-Cell Chemotactic Factor2 3     C-X-C Motif Chemokine 83
3-10C1     Neutrophil-Activating Protein 13
AMCF-I1     Protein 3-10C3

External Ids:    HGNC: 60251   Entrez Gene: 35762   Ensembl: ENSG000001694297   OMIM: 1469305   UniProtKB: P101453   

Export aliases for IL8 gene to outside databases

Previous GC identifers: GC04P074845 GC04P075006 GC04P075072 GC04P074971 GC04P070417


Summaries
for IL8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IL8:
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators
of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and
is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a
common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene
family form a chemokine gene cluster in a region mapped to chromosome 4q. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL8_HUMAN, P10145
Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also
involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus.
IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil
activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively

Gene Wiki entry for IL8 (Interleukin 8)


Genomic Views
for IL8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL8 gene promoter:
         GR   AML1a   HNF-4alpha2   NF-E2 p45   HNF-4alpha1   C/EBPalpha   GR-alpha   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL8 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13-q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13-q21

IL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL8 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074595:  view genomic region     (about GC identifiers)

Start:
 74,606,223 bp from pter      End:
 74,609,433 bp from pter
Size:
 3,211 bases      Orientation:
 plus strand

Proteins
for IL8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IL8_HUMAN, P10145 (See protein sequence)
Recommended Name: Interleukin-8 precursor  
Size: 99 amino acids; 11098 Da
Subunit: Homodimer
Subcellular location: Secreted
6/10 PDB 3D structures from and Proteopedia for IL8 (see all 10):
1ICW (3D)        1IKL (3D)        1IKM (3D)        1IL8 (3D)        1ILP (3D)        1ILQ (3D)    
Secondary accessions: B2R4L8 Q6FGF6 Q6LAE6 Q96RG6 Q9C077 Q9UCE1 Q9UCR8 Q9UCR9 Q9UCS0
Alternative splicing: 2 isoforms:  P10145-1   P10145-2   

Explore the universe of human proteins at neXtProt for IL8: NX_P10145

Post-translational modifications:

  • Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood
    • monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is
    the most promiment form1
  • Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly
    • through impaired chemokine clearance from the blood circulation1
  • View neXtProt modification sites for NX_P10145

    • IL8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000575.1  
    ENSEMBL proteins: 
     ENSP00000306512   ENSP00000385908  
    Reactome Protein details: P10145
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant IL8 Protein
    R&D Systems Recombinant & Natural Proteins for IL8 (CXCL8/IL-8)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: IL8
    OriGene Protein Over-expression Lysate: IL8
    OriGene Custom Protein Services for IL8 
    GenScript Purified and Recombinant Proteins for IL8
    Novus Biologicals IL8 Proteins
    Novus Biologicals IL8 Lysates
    Sino Biological Recombinant Protein for IL8
    ProSpec Recombinant Protein for IL8
    Uscn Proteins for IL8

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005622intracellular ----


    IL8 for ontologies           About GeneDecksing



    IL8 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL8
    R&D Systems Antibodies for IL8 (CXCL8/IL-8)
    Cell Signaling Technology (CST) Antibodies for IL8 
    OriGene Antibodies (see all 3): IL8
    OriGene Custom Antibody Services for IL8 
    GenScript Superior Antibodies for IL8
    Novus Biologicals IL8 Antibodies
    Abcam antibodies for IL8 
    Uscn Antibodies for IL8
    ThermoFisher Antibody for IL8

    Assay Products for IL8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Flow Cytometry Kits for IL8 (CXCL8/IL-8)         (see all)
    GenScript Custom Assay Services for IL8
    Cell Signaling Technology (CST) Sandwich ELISA Kits for IL8
    Enzo Life Sciences assays for IL8
    Uscn ELISAs and CLIAs for IL8

    Protein Domains /
    Families
    for IL8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IL8 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS
     IPR027206 IL8
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P10145

    ProtoNet protein and cluster: P10145

    1 Blocks protein family: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: IL8_HUMAN, P10145
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Function
    for IL8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IL8_HUMAN, P10145
    Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also
    involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus.
    IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil
    activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively
    Induction: By ER stress in a DDIT3/CHOP-dependent manner

         Genatlas biochemistry entry for IL8:
    interleukin 8 (see IMC2@),neutrophil activating peptide 1,monocyte-derived neutrophil chemotactic factor,with a direct
    growth potentiating activity in malignant mesothelioma

    miRNA
    Products:            		miRTarBase miRNAs that target IL8:
    hsa-mir-146a (MIRT004409), hsa-mir-204 (MIRT005832)

    OriGene 3'-UTR Clone: IL8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL8
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate IL8 (see all 33):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-372 hsa-miR-93 hsa-miR-889 hsa-miR-302b
    SwitchGear 3'UTR luciferase reporter plasmid: IL8 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL8
    OriGene shRNA RFP: IL8
    OriGene siRNA: IL8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL8

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IL8

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL8
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IL8 (NM_000584)
    Sino Biological Human cDNA Clone for IL8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL8 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IL8
    Search LifeMap BioReagents cell lines for IL8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL8

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005153interleukin-8 receptor binding IPI1840701
    GO:0005515protein binding IPI10880251
    GO:0008009chemokine activity IEA--


    IL8 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for IL8:
     Increased cell death in breast  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Il8tm1Lira for IL8
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Il8):
     hematopoietic system  immune system 

    IL8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IL8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/52 super-pathways (see all 52) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/12 pathways (see all 12)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    2TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		Regulation of eIF4 and p70S6K0.43
    		MAPK Family Pathway0.60
    		SOCS Pathway0.29
    		JAK-STAT Pathway0.57
    3Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    		G alpha (i) signalling events0.44
    4Toll-like receptor signaling pathway
    		Toll-like receptor signaling pathway1.00
    		Toll-Like receptor Signaling Pathways0.51
    		Toll-like receptor signaling pathway0.97
    		Chagas disease (American trypanosomiasis)0.31
    5Mucin expression in CF via IL-6, IL-17 signaling pathways
    		Cytokine production by Th17 cells in CF0.45
    		Immune response_MIF-mediated glucocorticoid regulation0.28
    		Cytokine production by Th17 cells in CF (Mouse model)0.37
    		Immune response MIF-mediated glucocorticoid regulation0.28

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/8 EMD Millipore Pathways for IL8 (see all 8)
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Role of integrins in NK cells cytotoxicity
    Selected targets of GCR-alpha
    Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response

    1 R&D Systems Pathway for IL8
        Toll-Like receptor Signaling Pathways

    24/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL8 (see all 27) (see first 5)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling
    Transendothelial Migration of Leukocytes
    MAPK Family Pathway
    Rho Family GTPases
    MIF Mediated Glucocorticoid Regulation
    Akt Signaling
    PAK Pathway
    Chemokine Signaling
    MIF Regulation of Innate Immune Cells
    Cytokine Network
    STAT3 Pathway
    JAK-STAT Pathway
    Glucocorticoid Receptor Signaling
    TGF-Beta Pathway
    SOCS Pathway
    ERK Signaling
    all-trans-Retinoic Acid Signaling in Brain
    PGC1Alpha Pathway
    p38 Signaling
    PEDF Induced Signaling

    1 Cell Signaling Technology (CST) Pathway for IL8
        Lymphocyte Signaling

    5/14 GeneGo (Thomson Reuters) Pathways for IL8 (see all 14)
        Immune response MIF-mediated glucocorticoid regulation
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Immune response TLR signaling pathways
    Apoptosis and survival Lymphotoxin-beta receptor signaling

    5/13 BioSystems Pathways for IL8 (see all 13) 
        SIDS Susceptibility Pathways
    EBV LMP1 signaling
    Senescence and Autophagy
    TSLP Signaling Pathway
    Toll-like receptor signaling pathway

    5/13        Reactome Pathways for IL8 (see all 13)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)


    5/16         Kegg Pathways  (Kegg details for IL8) (see all 16):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway
    RIG-I-like receptor signaling pathway


    IL8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/93 Interacting proteins for IL8 (P101453 ENSP000003065124) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PF4P027763, ENSP000002960294I2D: score=3 STRING: ENSP00000296029
    MTDHQ86UE43, ENSP000003382354I2D: score=1 STRING: ENSP00000338235
    RPS3P233963, ENSP000002785724I2D: score=1 STRING: ENSP00000278572
    CXCR2P250253, ENSP000003196354I2D: score=4 STRING: ENSP00000319635
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis TAS11483765
    GO:0002237response to molecule of bacterial origin IDA19912257
    GO:0006928cellular component movement TAS10820279
    GO:0006954inflammatory response TAS11483765
    GO:0006955immune response IEA--


    IL8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IL8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL8

    2 HMDB Compounds for IL8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Salbutamol(l)-albuterol (see all 97)18559-94-9--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--
    10/138 Novoseek chemical compound relationships for IL8 gene (see all 138)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 92.7 1369 9723955 (8), 17207890 (7), 10619832 (7), 16413378 (6) (see all 99)
    groalpha 86.1 191 11495082 (7), 9641651 (7), 17922696 (5), 9889409 (4) (see all 81)
    fmlp 79.7 471 7837814 (9), 16249234 (7), 15494208 (5), 9013980 (5) (see all 99)
    leukotriene b4 78.5 560 8003341 (9), 8973284 (5), 9482389 (5), 12149532 (5) (see all 99)
    vegf 76.4 1297 11234901 (9), 10334214 (9), 17349553 (8), 9457313 (8) (see all 99)
    endotoxin 74.4 268 2007851 (5), 11451261 (5), 18485432 (4), 16384605 (4) (see all 99)
    grogamma 72.8 23 8702798 (3), 15832427 (2), 9553055 (2), 10695618 (1) (see all 11)
    grobeta 68 26 10600366 (3), 8702798 (3), 15832427 (2), 9553055 (2) (see all 12)
    il 10 67.4 70 18363812 (4), 9543183 (2), 19723087 (2), 20041183 (2) (see all 56)
    lipoteichoic acid 67.3 89 10570304 (7), 16619004 (4), 8262617 (4), 19250704 (3) (see all 37)

    Search CenterWatch for drugs/clinical trials and news about IL8 

    Transcripts
    for IL8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IL8 gene: 
    NM_000584.3  

    Unigene Cluster for IL8:

    Interleukin 8
    Hs.624  [show with all ESTs]
    Unigene Representative Sequence: NM_000584
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307407(uc003hhe.3) ENST00000401931 ENST00000483500

    miRNA
    Products:             		 OriGene 3'-UTR Clone: IL8
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL8
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate IL8 (see all 33):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-372 hsa-miR-93 hsa-miR-889 hsa-miR-302b
    SwitchGear 3'UTR luciferase reporter plasmid: IL8 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL8
    OriGene shRNA RFP: IL8
    OriGene siRNA: IL8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL8
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL8
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IL8 (NM_000584)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL8 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IL8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL8

    Additional cDNA sequence: 

    AK131067.1 AK311874.1 BC013615.1 BT007067.1 CR542151.1 M17017.1 M26383.1 Y00787.1 
    Z11686.1 

    23 DOTS entries:

    DT.92451091  DT.452985  DT.121222191  DT.100764374  DT.121222188  DT.100890247  DT.121222199  DT.97822713 
    DT.121222180  DT.100722366  DT.121222165  DT.100890251  DT.92451100  DT.95366903  DT.100890241  DT.100890254 
    DT.121222196  DT.92451094  DT.92451101  DT.100890252  DT.100890257  DT.100890262  DT.92451080 

    24/756 AceView cDNA sequences (see all 756):

    AA362358 AA381584 CB306060 BX358167 CR601902 AW780211 BE122713 BQ101101 
    AA362192 BQ431044 CA308318 AA381931 CR595357 BM887846 BM055300 AA362139 
    BM955893 BM924085 AA381252 AA362196 CR623683 AA381576 AA381435 BQ051231 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IL8    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
    SP1:                                                
    SP2:                    -                           
    SP3:                                                


    ECgene alternative splicing isoforms for IL8

    Expression
    for IL8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGAAGCACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IL8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PlacentaChorionic VillusVillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    PlacentaExtravillous Cytotrophoblast LayerExtravillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See IL8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL8

    SOURCE GeneReport for Unigene cluster: Hs.624
        SABiosciences Expression via Pathway-Focused PCR Arrays including IL8 (see all 24): 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL8
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL8

    Orthologs
    for IL8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IL8 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IL81 interleukin 8 60.76(n)
    52.08(a)    		   396495  NM_205498.1  NP_990829.1 
    lizard
    (Anolis carolinensis)    		 Reptilia IL86
    		 --
    		 42(a)
    		 1 ↔ 1
    		 AAWZ02035874(23277-25185)


    ENSEMBL Gene Tree for IL8 (if available)
    TreeFam Gene Tree for IL8 (if available) 

    Paralogs
    for IL8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL8 gene
    PPBP2  PF42  CXCL12  PF4V12  CXCL62  CXCL32  CXCL52  CXCL22  
    18/25 SIMAP similar genes for IL8 using alignment to 2 protein entries:     IL8_HUMAN (see all proteins) (see all similar genes):
    CXCL6    CXCL5    PPBP    PF4    CXCL1    CXCL2
    CXCL12    CXCL3    PF4V1    CCL8    CCL3L1    CCL3L3
    CCL11    CCL18    CCL5    CXCL13    CXCL10    CCL2

    IL8 for paralogs           About GeneDecksing



    Genomic Variants
    for IL8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): IL8
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL8
    DNA2.0 Custom Variant and Variant Library Synthesis for IL8

    Disorders / Diseases
    for IL8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IL8 for disorders           About GeneDecksing

    OMIM gene information: 146930    OMIM disorders: --

    20/434 diseases for IL8 (see all 434):    About MalaCards
    lung giant cell carcinoma    neutrophil-specific granule deficiency    bronchiolitis    specific granule deficiency
    erythema elevatum diutinum    muckle-wells syndrome    alpha 1-antitrypsin deficiency    estrogen-receptor negative breast cancer
    stenotrophomonas maltophilia    zollinger-ellison syndrome    glycogen storage disease type ia    large granular lymphocyte leukemia
    adult-onset still's disease    relapsing-remitting multiple sclerosis    extrinsic allergic alveolitis    cryptogenic organizing pneumonia
    common cold    diffuse large b-cell lymphoma    mycobacterium marinum    hypersensitivity reaction type ii disease

    13 diseases from the University of Copenhagen DISEASES database for IL8:
    Lung disease     Cancer     Gastritis     Cystic fibrosis
    Vascular disease     Periodontitis     Chorioamnionitis     Inflammatory bowel disease
    Arthritis     Mastitis     Endometriosis     Psoriasis
    Peptic ulcer

    10/98 Novoseek disease relationships for IL8 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 91.7 3968 9462219 (9), 8601968 (6), 10740342 (5), 1702929 (4) (see all 99)
    inflammation 90.2 1154 12697917 (4), 10680520 (4), 15104334 (4), 15901266 (4) (see all 99)
    tumors 81.8 3953 11181444 (8), 8601968 (6), 12471616 (6), 16088182 (5) (see all 99)
    bronchoalveolar lavage fluid 72.9 158 7712280 (4), 10933164 (3), 16077402 (3), 15909061 (3) (see all 99)
    systemic inflammatory response syndrome 70.3 31 8143477 (2), 9558403 (2), 9038289 (2), 16227031 (2) (see all 21)
    pulmonary disease chronic obstructive 68 39 8563494 (2), 12915744 (2), 11108181 (2), 16181530 (2) (see all 27)
    sepsis 66.2 233 1612748 (6), 17368039 (5), 15730597 (5), 9120108 (4) (see all 99)
    cystic fibrosis 65.2 102 7940424 (6), 7639556 (3), 8476069 (3), 17880760 (2) (see all 65)
    rheumatoid arthritis 64.5 130 1932367 (2), 8961381 (2), 14750259 (2), 10437780 (2) (see all 94)
    airways disease 63.8 23 7927669 (2), 10417151 (1), 10460760 (1), 9199432 (1) (see all 14)

    Genetic Association Database (GAD): IL8
    Human Genome Epidemiology (HuGE) Navigator: IL8 (282 documents)

    Export disorders for IL8 gene to outside databases

    Publications
    for IL8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL8 gene, integrated from 9 sources (see all 7102):
    (articles sorted by number of sources associating them with IL8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The neutrophil-activating proteins interleukin 8 and beta- thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. (PubMed id 2145175)1, 2, 9 van Damme J.... Billiau A. (1990)
    2. Polymorphisms of the IL-8 and CXCR2 genes are not associated with Behcet's disease. (PubMed id 15630732)1, 4, 9 Duymaz-Tozkir J....Gul A. (2005)
    3. Genetic variation in the interleukin-8 gene promoter and vaginal concentrations of interleukin-8 are not associated with bacterial vaginosis during pregnancy. (PubMed id 16038986)1, 4, 9 Diaz-Cueto L....Arechavaleta-Velasco F. (2005)
    4. Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers. (PubMed id 15902922)1, 4, 9 Gonzalez-Quintela A....Perez L.F. (2004)
    5. Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. (PubMed id 15356575)1, 4, 9 Heinzmann A....Deichmann K.A. (2004)
    6. Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. (PubMed id 15708897)1, 4, 9 Kawahara C....Loughlin J. (2005)
    7. Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis. (PubMed id 15917409)1, 4, 9 Howell W.M....Bateman A.C. (2005)
    8. Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. (PubMed id 16284368)1, 4, 9 Taguchi A....Goto H. (2005)
    9. Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma. (PubMed id 15598788)1, 4, 9 Savage S.A....Chanock S.J. (2004)
    10. Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis. (PubMed id 12415593)1, 4, 9 Amoli M.M....Gonzalez-Gay M.A. (2002)

    External Searches for IL8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IL8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3576 HGNC: 6025 AceView: IL8 Ensembl:ENSG00000169429 euGenes: HUgn3576
    ECgene: IL8 Kegg: 3576 H-InvDB: IL8

    Other Databases showing IL8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IL8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL8 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_8
    SeattleSNPshttp://pga.gs.washington.edu/data/il8/

    Intellectual Property
    for IL8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IL8 gene:
    Search GeneIP for patents involving IL8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IL8 gene

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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

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