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IL8 Gene

protein-coding   GIFtS: 67
GCID: GC04P074595

Interleukin 8

  See IL8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 81 2     T-Cell Chemotactic Factor2 3
Granulocyte Chemotactic Protein 11 2 3     GCP12
Monocyte-Derived Neutrophil Chemotactic Factor1 2 3     LECT2
Monocyte-Derived Neutrophil-Activating Peptide1 2 3     LUCT2
Alveolar Macrophage Chemotactic Factor I1 2     LYNAP2
Beta Endothelial Cell-Derived Neutrophil Activating Peptide1 2     NAF2
Chemokine (C-X-C Motif) Ligand 81 2     NAP12
Lung Giant Cell Carcinoma-Derived Chemotactic Protein1 2     Beta-Thromboglobulin-Like Protein2
Lymphocyte Derived Neutrophil Activating Peptide1 2     emoctakin2
Neutrophil-Activating Peptide 11 2     interleukin-82
Tumor Necrosis Factor-Induced Gene 11 2     Small Inducible Cytokine Subfamily B, Member 82
CXCL82 3     Emoctakin3
GCP-12 3     IL-83
MDNCF2 3     C-X-C Motif Chemokine 83
MONAP2 3     Neutrophil-Activating Protein 13
NAP-12 3     Protein 3-10C3

External Ids:    HGNC: 60251   Entrez Gene: 35762   Ensembl: ENSG000001694297   OMIM: 1469305   UniProtKB: P101453   

Export aliases for IL8 gene to outside databases

Previous GC identifers: GC04P074845 GC04P075006 GC04P075072 GC04P074971 GC04P070417


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL8 Gene:
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major
mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a
chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis
of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members
of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. (provided by
RefSeq, Jul 2008)

GeneCards Summary for IL8 Gene:
IL8 (interleukin 8) is a protein-coding gene. Diseases associated with IL8 include bronchiolitis, and mycobacterium marinum. GO annotations related to this gene include interleukin-8 receptor binding and chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: IL8_HUMAN, P10145
Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is
also involved in neutrophil activation. It is released from several cell types in response to an inflammatory
stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity
on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to
IL-8(1-77), respectively

Gene Wiki entry for IL8 (Interleukin 8) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL8 gene promoter:
         GR   AML1a   HNF-4alpha2   NF-E2 p45   HNF-4alpha1   C/EBPalpha   GR-alpha   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL8 promoter sequence
   Search Chromatin IP Primers for IL8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13-q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13-q21

IL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL8 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074595:  view genomic region     (about GC identifiers)

Start:
74,606,223 bp from pter      End:
74,609,433 bp from pter
Size:
3,211 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL8_HUMAN, P10145 (See protein sequence)
Recommended Name: Interleukin-8 precursor  
Size: 99 amino acids; 11098 Da
Subunit: Homodimer
Selected PDB 3D structures from and Proteopedia for IL8 (see all 10):
1ICW (3D)        1IKL (3D)        1IKM (3D)        1IL8 (3D)        1ILP (3D)        1ILQ (3D)    
Secondary accessions: B2R4L8 Q6FGF6 Q6LAE6 Q96RG6 Q9C077 Q9UCE1 Q9UCR8 Q9UCR9 Q9UCS0
Alternative splicing: 2 isoforms:  P10145-1   P10145-2   

Explore the universe of human proteins at neXtProt for IL8: NX_P10145

Explore proteomics data for IL8 at MOPED

Post-translational modifications: 

  • Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral
    blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8.
    IL-8(6-77) is the most promiment form1
  • Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis,
    possibly through impaired chemokine clearance from the blood circulation1
  • Modification sites at neXtProt

  • See IL8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000575.1  
    ENSEMBL proteins: 
     ENSP00000306512   ENSP00000385908  
    Reactome Protein details: P10145

    IL8 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IL8 Protein
    R&D Systems Recombinant & Natural Proteins for IL8 (CXCL8/IL-8)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IL8
    OriGene Protein Over-expression Lysate for IL8
    OriGene MassSpec for IL8
    OriGene Custom Protein Services for IL8
    GenScript Purified and Recombinant Proteins for IL8
    Novus Biologicals IL8 Proteins
    Novus Biologicals IL8 Lysates
    Sino Biological Recombinant Protein for IL8
    Sino Biological Cell Lysate for IL8
    ProSpec Recombinant Protein for IL8
    Cloud-Clone Corp. Proteins for IL8

     
    eBioscience Proteins for IL8: (see all 3
                        Human IL-8 Recombinant Protein Carrier-Free 100 ug

    IL8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL8
    R&D Systems Antibodies for IL8 (CXCL8/IL-8)
    OriGene Antibodies for IL8
    OriGene Custom Antibody Services for IL8
    Novus Biologicals IL8 Antibodies
    Abcam antibodies for IL8
    Cloud-Clone Corp. Antibodies for IL8
    ThermoFisher Antibody for IL8
    LSBio Antibodies in human, mouse, rat for IL8

    IL8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL8
    R&D Systems Flow Cytometry Kits for IL8 (CXCL8/IL-8)         (see first)
    R&D Systems ELISAs for IL8 (CXCL8/IL-8)
    R&D Systems ELISpot/FluoroSpot Kits & Development Modules for IL8 (CXCL8/IL-8)
    R&D Systems Luminex Assays for IL8 (CXCL8/IL-8)
    R&D Systems Proteome Profiler Antibody Arrays for IL8 (CXCL8/IL-8)
    See all other biochemical assays at R&D Systems
    GenScript Custom Assay Services for IL8
    Enzo Life Sciences assays for IL8
    Cloud-Clone Corp. ELISAs for IL8
    Cloud-Clone Corp. CLIAs for IL8
    eBioscience ELISAs for IL8: (see all 7
                        Human IL-8 ELISA Ready-SET-Go! (To Be Discontinued. Refer to 2nd Generation RSG Version: cat. 88-8086) 2 x 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR028469 Interleukin-8
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P10145

    ProtoNet protein and cluster: P10145

    1 Blocks protein domain: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: IL8_HUMAN, P10145
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Find genes that share domains with IL8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL8_HUMAN, P10145
    Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is
    also involved in neutrophil activation. It is released from several cell types in response to an inflammatory
    stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity
    on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to
    IL-8(1-77), respectively
    Induction: By ER stress in a DDIT3/CHOP-dependent manner

         Genatlas biochemistry entry for IL8:
    interleukin 8 (see IMC2@),neutrophil activating peptide 1,monocyte-derived neutrophil chemotactic factor,with a
    direct growth potentiating activity in malignant mesothelioma

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005153interleukin-8 receptor binding IPI1840701
    GO:0005515protein binding IPI10880251
    GO:0008009chemokine activity TAS12782716
         
    Find genes that share ontologies with IL8           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for IL8:
     Increased cell death in breast  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il8):
     hematopoietic system  immune system 

    Find genes that share phenotypes with IL8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cxcl15tm1Lira for IL8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL8

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL8:
    hsa-mir-146a-5p (MIRT004409), hsa-mir-124-3p (MIRT023079), hsa-mir-155-5p (MIRT020979), hsa-mir-204-5p (MIRT005832), hsa-mir-1 (MIRT024086), hsa-mir-335-5p (MIRT019032)

    Block miRNA regulation of human, mouse, rat IL8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL8 (see all 33):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-372 hsa-miR-93 hsa-miR-889 hsa-miR-302b
    SwitchGear 3'UTR luciferase reporter plasmidIL8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL8
    Predesigned siRNA for gene silencing in human, mouse, rat IL8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL8

    Clone
    Products:
         
    OriGene clones in human, mouse for IL8 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL8 (NM_000584)
    Sino Biological Human cDNA Clone for IL8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL8
    Addgene plasmids for IL8 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL8
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL8

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-13103 VA4-13193 VA6-13192) for IL8 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL8_HUMAN, P10145: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    cytoskeleton2
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IL8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL8 About   (see all 56)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    Regulation of toll-like receptor signaling pathway0.93
    3NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    NOD-like Receptor Signaling Pathways0.58
    4Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    Bacterial infections in CF airways0.78
    5Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81


    Find genes that share SuperPaths with IL8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for IL8
        NOD-like Receptor Signaling Pathways
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL8 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling

    Selected GeneGo (Thomson Reuters) Pathways for IL8 (see all 14)
        Immune response MIF-mediated glucocorticoid regulation
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Immune response TLR signaling pathways
    Apoptosis and survival Lymphotoxin-beta receptor signaling

    Selected BioSystems Pathways for IL8 (see all 15)
        EBV LMP1 signaling
    Senescence and Autophagy
    SIDS Susceptibility Pathways
    Spinal Cord Injury
    Toll-like receptor signaling pathway


    5 Reactome Pathways for IL8
        Peptide ligand-binding receptors
    Senescence-Associated Secretory Phenotype (SASP)
    Chemokine receptors bind chemokines
    G alpha (i) signalling events
    ATF4 activates genes


    Selected Kegg Pathways  (Kegg details for IL8) (see all 22):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    NF-kappa B signaling pathway
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL8 (see all 24): 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL8 (P101451, 3 ENSP000003065124) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR2P250251, 3, ENSP000003196354EBI-3917999,EBI-2835281 I2D: score=4 STRING: ENSP00000319635
    PF4P027763, ENSP000002960294I2D: score=3 STRING: ENSP00000296029
    MTDHQ86UE43, ENSP000003382354I2D: score=1 STRING: ENSP00000338235
    RPS3P233963, ENSP000002785724I2D: score=1 STRING: ENSP00000278572
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis TAS11483765
    GO:0002237response to molecule of bacterial origin IDA19912257
    GO:0006928cellular component movement TAS10820279
    GO:0006935chemotaxis TAS12782716
    GO:0006954inflammatory response TAS11483765

    Find genes that share ontologies with IL8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL8

    2 HMDB Compounds for IL8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Salbutamol(l)-albuterol (see all 97)18559-94-9--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    Selected Novoseek inferred chemical compound relationships for IL8 gene (see all 138)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 92.7 1369 9723955 (8), 17207890 (7), 10619832 (7), 16413378 (6) (see all 99)
    groalpha 86.1 191 11495082 (7), 9641651 (7), 17922696 (5), 9889409 (4) (see all 81)
    fmlp 79.7 471 7837814 (9), 16249234 (7), 15494208 (5), 9013980 (5) (see all 99)
    leukotriene b4 78.5 560 8003341 (9), 8973284 (5), 9482389 (5), 12149532 (5) (see all 99)
    vegf 76.4 1297 11234901 (9), 10334214 (9), 17349553 (8), 9457313 (8) (see all 99)
    endotoxin 74.4 268 2007851 (5), 11451261 (5), 18485432 (4), 16384605 (4) (see all 99)
    grogamma 72.8 23 8702798 (3), 15832427 (2), 9553055 (2), 10695618 (1) (see all 11)
    grobeta 68 26 10600366 (3), 8702798 (3), 15832427 (2), 9553055 (2) (see all 12)
    il 10 67.4 70 18363812 (4), 9543183 (2), 19723087 (2), 20041183 (2) (see all 56)
    lipoteichoic acid 67.3 89 10570304 (7), 16619004 (4), 8262617 (4), 19250704 (3) (see all 37)



    Find genes that share compounds with IL8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL8 gene: 
    NM_000584.3  

    Unigene Cluster for IL8:

    Interleukin 8
    Hs.624  [show with all ESTs]
    Unigene Representative Sequence: NM_000584
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307407(uc003hhe.3) ENST00000401931 ENST00000483500
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IL8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL8 (see all 33):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-372 hsa-miR-93 hsa-miR-889 hsa-miR-302b
    SwitchGear 3'UTR luciferase reporter plasmidIL8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IL8
    Predesigned siRNA for gene silencing in human, mouse, rat IL8
    Clone
    Products:
         
    OriGene clones in human, mouse for IL8 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL8 (NM_000584)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL8
    Addgene plasmids for IL8 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL8
    OriGene qSTAR qPCR primer pairs in human, mouse for IL8
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IL8
      QuantiTect SYBR Green Assays in human, mouse, rat IL8
      QuantiFast Probe-based Assays in human, mouse, rat IL8
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-13103 VA4-13193 VA6-13192) for IL8 

    Additional mRNA sequence: 

    AK131067.1 AK311874.1 BC013615.1 BT007067.1 CR542151.1 M17017.1 M26383.1 Y00787.1 
    Z11686.1 

    Selected DOTS entries (see all 25):

    DT.92451091  DT.452985  DT.97822713  DT.121222191  DT.100764374  DT.121222188  DT.100890247  DT.121222199 
    DT.121222180  DT.100722366  DT.100890252  DT.121222165  DT.100890251  DT.100890257  DT.92451100  DT.92451101 
    DT.95366903  DT.100691364  DT.100842594  DT.100890241  DT.100890254  DT.121222196  DT.92451080  DT.92451094 

    756 AceView cDNA sequences (see top 24):

    BM907296 AA362132 BQ101101 CR600500 AI346866 CR619554 AA362358 BU158818 
    BM887846 BM924085 AA381999 BX396678 AA381177 AW662358 AW780211 AA381931 
    CR601533 AA381625 BM128212 CD364559 AW662719 AA381584 BE042737 AW769268 
    BQ431044 NM_000584 AW273112 BM069584 AA381217 CA306746 BX462017 BQ216454 
    BE122713 CB851080 AA362246 BQ219392 BI962588 AA381395 CA307868 BQ003056 
    AA381795 BP336876 BQ129279 AA381435 BQ215118 CA308318 BU626699 AA381952 
    AW662707 AA381454 AA381700 BU186293 BM955893 BU159049 CK904775 AA362196 
    BF445462 AA381576 CR603686 AA381715 BM126840 BI789121 AA381848 Z11686 
    CR595357 AW467270 AA362357 BQ932618 BM069824 CR601902 AI697109 CR594973 
    CR623683 CB306060 AA381914 CR623827 BU181108 AI952442 BQ051231 AW467973 
    AA362139 BM888479 CR542151 BU686095 AI634748 BC013615 AA362188 AA381228 
    AV716793 BQ225540 BX358167 AA381356 AK131067 BM055300 BM976609 AA362192 
    BU169639 AA381699 BP337922 AA381891 BU153304 BG778571 AA381252 CD367465 
    BQ934851 BQ100994 AA381459 CD521704 CD523337 CD522432 CD677897 AA361981 
    CD641791 BI761140 CD523281 BV167919 CD638340 AL711111 AW015490 AA381679 
    BM054955 AV756825 CD367954 CD523423 CD638826 CD641945 BE788958 CD638283 
    AW613454 BQ225563 CD640984 CD520889 AV758152 CD520102 CD523419 CD642096 
    CD640979 BM126584 AA363453 AA381845 AV715130 BQ232784 CD522578 CD642080 
    BE787019 BU928438 CD520849 CD641389 BU571083 BG426111 CD640805 CD521486 
    BE788777 CD559271 CD522119 CD521156 BU571147 BG500757 CD640965 BU198348 
    BX335639 CD638384 BE789993 CD641300 AV716939 CD639989 AI079248 CD638835 
    CD639054 CD522329 CD520498 CD521692 W40163 BG497712 CD639279 BF344351 
    CD521921 BU928326 CD639519 BG536682 CD638843 CD523315 AV717293 AA381229 
    CA426635 CD523199 CD639562 AV717657 BE439795 CD642140 BU928624 CD522948 
    BU928380 BT007067 AW951160 AW630501 AV712859 AA381601 AA381669 CD641077 
    CD641845 AA381456 CD641216 CA307813 CD521797 CD520568 CD522167 M26383 
    CD522180 BX358166 BG118436 AU137355 CA309072 AV717936 AW615017 AV731724 
    AA362133 CD640600 BF590498 BX429908 AV714604 W40425 T11037 CD640296 
    CD521098 CD639009 CD521672 CD638411 CD520685 CD521395 AA381813 CD642041 
    AA381355 CD642073 BQ213671 CD520239 BX337862 CD641971 AV717237 CD521468 
    BE738445 CD522745 AA382057 BF218067 BU571057 AV717082 BM055206 CD520193 
    W45271 CD367072 CD641376 W38334 AW337841 D56519 CD520736 CD640987 
    CD639459 AA363596 T11309 BX365367 CD640143 BM128443 AW059870 BX398114 
    CD640748 BG779686 CD520623 AA381577 CD521032 BU689976 BU155256 BE786220 
    AJ227913 BU170071 CD640573 BQ002827 BU928318 CD641511 CD520962 CD522647 
    AW272835 CD641136 AA381670 CA310339 BG547297 CD520642 BG058515 BE789962 
    AW188453 CD521166 AV756788 AV755442 AW468452 BU928951 T11379 BM907331 
    CD638776 CD521051 CD640943 BX413857 CD640018 AA381318 AV714375 CD641883 
    CD559322 CD520997 CD639297 BQ214420 CD521986 AV714235 BQ100809 AA363545 
    AV755322 CD522485 CD641505 CD638324 AV713897 AI355474 CD559385 CD522395 
    CD520146 CD639846 CA307406 CD638295 BU192427 CD642042 CD559344 CD642138 
    CD521241 CD641906 AI469266 AA360958 AA381472 CD639351 CD639749 CD520314 
    CD641366 BM821180 CD640895 CD521962 AA381592 AV715174 BE786369 CD559347 
    AV712466 AI922031 CD521195 CD520204 AA363550 CD520394 AW075978 AA363540 
    BX453256 CD641043 CD641085 CD639152 CD641499 BQ716911 CD520237 BM127905 
    CD639274 CD520307 CD639764 CD522587 CD521554 AA362160 CD521628 BG939683 
    AV716097 CD640466 CD559211 AA381781 BM833252 BQ003603 AV717597 AA381767 
    AA381877 CD521484 BG231552 AA363554 AW272612 CD641495 CD521047 BU928338 
    BG142154 W40279 CD522511 CD639446 CD639644 BM055022 CD638348 CD521390 
    CD639042 AA381618 W60423 CD638490 AA362337 AV714401 AI310352 BX365368 
    W60450 Y00787 CD638307 CD640946 BU186618 AA362140 AV763571 AA382015 
    D82254 CD520206 CD638640 CB135446 BU571136 CD639489 CD520848 BU626684 
    CD639922 CD638620 AI620395 CA748621 CD638414 M17017 CD639392 BQ100716 
    AA381710 CD639796 BU928535 CD522730 AI087873 AV713473 CD366543 BU198780 
    CD640872 AV716508 CD638465 BU928681 AV716799 CD522027 BX397623 AW272671 
    AV717919 BE785606 AW510601 BU192445 D82198 AV713876 BU928510 BG777366 
    BE439924 AI473944 CD640504 CD639192 CD640180 CD522618 CD638669 CD638543 
    BE439515 BX360446 BG501199 BX453257 BG779880 W40283 AA381426 CD639946 
    BG119142 CD559253 CD522561 CA309273 CD520464 CD640417 AI457250 BG570089 
    CD640756 AW604306 BU169458 CD638940 BE787424 CD520598 CD638590 T27467 
    CD559429 AA381653 BE737839 AW591509 AA363559 CD559240 BG117814 BX339262 
    BU199053 AV712481 AA346136 CD521124 CD639476 AW631242 AI274317 AW950718 
    CD639908 CD639157 AA381833 AW339521 AI380580 AA371394 AA363599 BQ129430 
    AW341742 CD639952 T68419 CD640543 AA362269 CD638574 BG537689 CD640909 
    AV757045 CD642015 AA362270 AI476632 BE790166 BF687713 AA363589 AA381897 
    CD642061 AW377023 BU656350 CD520294 BU929074 AV714345 BG057857 CD520975 
    BX335640 BF341536 CD559326 AV682988 BU198124 D83813 AA381517 CD641107 
    BM129086 CD640885 AA381965 T29157 BF185796 BM924065 AA296403 BX365124 
    CD559381 CD522972 AW440851 AA381816 AW367405 BE785449 BU674113 BG540597 
    AV758699 W45362 AV757635 CD640678 AA372837 AA381967 CD638476 AA381623 
    CD559412 CD523384 W56111 CD639150 AV757876 BU192223 CD521987 D82102 
    AI579895 BF185745 CD641489 CF129689 AW780131 BU198938 W52491 AV730264 
    BF130542 AA381189 D82615 BQ231178 BF245850 CD522758 CD521942 AA362127 
    BU753499 AW959358 AI564251 D82218 CD521404 BM984034 AA362107 CD520643 
    AV716041 AV717063 AI431254 AI953422 C01358 AV712529 BF526422 BF216779 
    BU679841 BX476182 D83842 BF219089 BV179378 AV756916 AA374516 BU674826 
    AW470168 CD520538 CD522990 CD639837 BU674699 BG661290 D83848 CD640136 
    CD609064 BU675962 AV755467 BF218599 BU674723 AJ713849 W45409 CD609065 
    CD640491 CD521883 AA381274 CD640422 AA381702 BF216476 W45324 CK904774 
    AA381603 BI962664 AA102526 BM969541 AA381992 AA363514 BX365125 T11316 
    CD640468 BF218222 CD523263 T11198 W39356 BM969906 CD521499 BF381993 
    AI282685 AV714023 BE004230 D82618 AI569162 AV712540 CD523216 CD523112 
    BF217309 AA381218 AV755680 AA382121 T27482 BM128836 T68485 AA381806 
    AI475413 CD640830 AV737712 AW779405 D83837 BE788563 CD522090 CD521171 
    CD640482 CD559357 AV756289 CD240350 W52968 CD522245 AV756855 AV757312 
    CD520246 AA095727 CD522159 AJ714367 AW627475 CD520531 BF215685 AW951601 
    C05929 AV716932 BE138893 AA362187 AA305271 AV756323 W46290 AA380965 
    BE787783 AV714638 D83856 BF216952 AV755816 AV717066 AA381309 AF043337 
    T10915 W40401 BP336068 CD640894 CD639568 C05902 BF382624 AA082747 
    T11140 D83851 BU928762 T18459 CD240252 AV712107 BF244683 BF244611 
    CD521451 D82132 C06304 CD522754 BF244370 CD522001 AJ713411 T11145 
    CD523011 BF849216 AW663238 AA304441 AI375262 CD523399 AV755227 AW051250 
    CD639107 BG778503 AI469815 AA568576 BF030787 AI541051 BE787989 BX337861 
    CD523252 BF081482 AW467642 BI048823 BF245485 AV711873 BF219430 AV758598 
    BQ212818 T11274 AV758075 BQ212099 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IL8    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
    SP1:                                                
    SP2:                    -                           
    SP3:                                                


    ECgene alternative splicing isoforms for IL8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IL8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAGCACT
    IL8 Expression
    About this image


    IL8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Mesenchymal Stem Cells
             Placenta-derived mesenchymal stem cells (family)
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Angiogenic cell precursor
             Endothelial-like cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
             Angiogenic cell precursor
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 4 entries
             Villous Cytotrophoblast Cells Chorionic Villus
             Placenta-derived mesenchymal stem cells (family)
    IL8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.624
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL8 (see all 24): 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL8
    OriGene qSTAR qPCR primer pairs in human, mouse for IL8
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IL8
    QuantiTect SYBR Green Assays in human, mouse, rat IL8
    QuantiFast Probe-based Assays in human, mouse, rat IL8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for IL8 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il85 chemokine (C-X-C motif) ligand 15   --   5 (44.78 cM) 90794534 
    chicken
    (Gallus gallus)
    Aves IL86
    K606
    Gallus gallus interleukin 8-like 1 (IL8L1), mRNA.
    48(a)
    46(a)
    1 ↔ many
    1 ↔ many
    4(50355001-50359957)
    4(50342296-50345374)
    lizard
    (Anolis carolinensis)
    Reptilia IL86
    interleukin 8
    40(a)
    1 ↔ 1
    AAWZ02035874(23277-25185)


    ENSEMBL Gene Tree for IL8 (if available)
    TreeFam Gene Tree for IL8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for IL8 gene
    PPBP2  PF42  CXCL12  PF4V12  CXCL62  CXCL32  CXCL52  CXCL22  
    Selected SIMAP similar genes for IL8 using alignment to 2 protein entries:     IL8_HUMAN (see all proteins) (see all similar genes):
    CXCL6    CXCL5    PPBP    PF4    CXCL1    CXCL2
    CXCL12    CXCL3    PF4V1    CCL8    CCL3L1    CCL3L3
    CCL11    CCL18    CCL5    CXCL13    CXCL10    CCL2

    Find genes that share paralogs with IL8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL8 (see all 235)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017995791,2
    C--70419362(-) ATTCCC/TTTTTT 1 -- int10--------
    rs1429307391,2
    --74482423(+) AGCAAA/CGAAAC 1 -- us2k10--------
    rs1893147861,2
    C--74482435(+) TGGAGA/TTTTCT 1 -- us2k10--------
    rs1819367531,2
    --74482438(+) AGTTTC/TCTTTA 1 -- us2k10--------
    rs1510778081,2
    --74482464(+) TTACCA/TATCCG 1 -- us2k10--------
    rs1411041051,2
    C--74482562(+) ATTTCA/GTTGTC 1 -- us2k10--------
    rs22275271,2
    F--74482648(+) TTTGAT/AGTTGT 1 -- us2k12Minor allele frequency- A:0.02NS 86
    rs1859761031,2
    --74482749(+) TCATCA/GCTGTA 1 -- us2k10--------
    rs1906913091,2
    C--74482754(+) ACTGTA/GTTTTA 1 -- us2k10--------
    rs1451861541,2
    --74482816(+) TAAGTC/GAGGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL8 (74606223 - 74609433 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IL8: --
    Human Gene Mutation Database (HGMD): IL8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL8
    DNA2.0 Custom Variant and Variant Library Synthesis for IL8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 146930    OMIM disorders: --

    Selected diseases for IL8 (see all 68):    
    About MalaCards
    bronchiolitis    mycobacterium marinum    lung giant cell carcinoma    spermatocele
    meningitis    sepsis    mycobacterium fortuitum    adult respiratory distress syndrome
    chorioamnionitis    bagassosis    alcoholic hepatitis    sepsis in premature infants
    neutrophil-specific granule deficiency    pneumonia    common cold    aspiration pneumonia
    recurrent corneal erosion    cryptogenic organizing pneumonia    urethritis    sinusitis

    13 diseases from the University of Copenhagen DISEASES database for IL8:
    Lung disease     Cancer     Gastritis     Cystic fibrosis
    Vascular disease     Periodontitis     Chorioamnionitis     Inflammatory bowel disease
    Arthritis     Mastitis     Psoriasis     Endometriosis
    Peptic ulcer

    Find genes that share disorders with IL8           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL8 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 91.7 3968 9462219 (9), 8601968 (6), 10740342 (5), 1702929 (4) (see all 99)
    inflammation 90.2 1154 12697917 (4), 10680520 (4), 15104334 (4), 15901266 (4) (see all 99)
    tumors 81.8 3953 11181444 (8), 8601968 (6), 12471616 (6), 16088182 (5) (see all 99)
    bronchoalveolar lavage fluid 72.9 158 7712280 (4), 10933164 (3), 16077402 (3), 15909061 (3) (see all 99)
    systemic inflammatory response syndrome 70.3 31 8143477 (2), 9558403 (2), 9038289 (2), 16227031 (2) (see all 21)
    pulmonary disease chronic obstructive 68 39 8563494 (2), 12915744 (2), 11108181 (2), 16181530 (2) (see all 27)
    sepsis 66.2 233 1612748 (6), 17368039 (5), 15730597 (5), 9120108 (4) (see all 99)
    cystic fibrosis 65.2 102 7940424 (6), 7639556 (3), 8476069 (3), 17880760 (2) (see all 65)
    rheumatoid arthritis 64.5 130 1932367 (2), 8961381 (2), 14750259 (2), 10437780 (2) (see all 94)
    airways disease 63.8 23 7927669 (2), 10417151 (1), 10460760 (1), 9199432 (1) (see all 14)

    Genetic Association Database (GAD): IL8
    Human Genome Epidemiology (HuGE) Navigator: IL8 (282 documents)

    Export disorders for IL8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for IL8 gene, integrated from 10 sources (see all 7249):
    (articles sorted by number of sources associating them with IL8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The neutrophil-activating proteins interleukin 8 and beta- thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. (PubMed id 2145175)1, 2, 9 van Damme J.... Billiau A. (Eur. J. Immunol. 1990)
    2. Polymorphisms of the IL-8 and CXCR2 genes are not associated with BehAset's disease. (PubMed id 15630732)1, 4, 9 Duymaz-Tozkir J....GA1l A. (J. Rheumatol. 2005)
    3. Lack of association of interleukin-6 and interleukin-8 gene polymorphisms in Chinese patients with systemic lupus erythematosus. (PubMed id 17115422)1, 4, 9 Huang C.M....Tsai F.J. (J. Clin. Lab. Anal. 2006)
    4. Polymorphisms in interleukin 8 and its receptors (IL8, IL8RA and IL8RB) and association of common IL8 receptor variants with peripheral blood eosinophil counts. (PubMed id 16897191)1, 4, 9 Cheong H.S....Park C.S. (J. Hum. Genet. 2006)
    5. Genetic variation in the interleukin-8 gene promoter and vaginal concentrations of interleukin-8 are not associated with bacterial vaginosis during pregnancy. (PubMed id 16038986)1, 4, 9 Diaz-Cueto L....Arechavaleta-Velasco F. (J. Reprod. Immunol. 2005)
    6. Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers. (PubMed id 15902922)1, 4, 9 GonzA!lez-Quintela A....Perez L.F. (Alcohol 2004)
    7. The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea. (PubMed id 19077731)1, 4, 9 Kang J.M....Song I.S. (J. Clin. Gastroenterol. 2009)
    8. Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. (PubMed id 16719905)1, 4, 9 SA!nchez E....Koeleman B.P. (BMC Med. Genet. 2006)
    9. Association of interleukin-8 with cachexia from patients with low-third gastric cancer. (PubMed id 20037740)1, 4, 9 Song B....Wang X. (Comp. Funct. Genomics 2009)
    10. T-251A polymorphism of IL-8 relating to the development of histological gastritis and G-308A polymorphism of TNF-alpha relating to the development of macroscopic erosion. (PubMed id 18301299)1, 4, 9 Szoke D....Tulassay Z. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3576 HGNC: 6025 AceView: IL8 Ensembl:ENSG00000169429 euGenes: HUgn3576
    ECgene: IL8 Kegg: 3576 H-InvDB: IL8

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IL8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL8 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_8
    SeattleSNPshttp://pga.gs.washington.edu/data/il8/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL8 gene:
    Search GeneIP for patents involving IL8

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     EMD Millipore Mono- and Polyclonal Antibodies for the study of IL8
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     OriGene Custom Antibody Services for IL8   OriGene Custom Protein Services for IL8  

     
     
     Block miRNA regulation of human, mouse, rat IL8 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IL8
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL8 Predesigned siRNA for gene silencing in human, mouse, rat IL8
     QuantiFast Probe-based Assays in human, mouse, rat IL8 QuantiTect SYBR Green Assays in human, mouse, rat IL8
     PCR Arrays including human, mouse / rat IL8 Search Chromatin IP Primers for IL8
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IL8  GeneGlobe Interaction Network for IL8
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     Search Tocris compounds for IL8
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     Search Sino Biological for antibodies, proteins & pathways
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     Abcam protocols and scientific support
     Recombinant Protein for IL8
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     Browse ESI BIO Cell Lines and PureStem Progenitors for IL8
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     SwitchGear 3'UTR luciferase reporter plasmids for IL8
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     ThermoFisher Antibody for IL8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL8
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL8
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     LSBio Antibodies in human, mouse, rat for IL8
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     Browse compounds at ApexBio
     Addgene plasmids for IL8
     eBioscience proteins for IL8 (Human IL-8 Recombinant Protein Carrier-Free 100 ug)
     eBioscience elisas for IL8 (Human IL-8 ELISA Ready-SET-Go! (To Be Discontinued. Refer to 2nd Generation RSG Version: cat. 88-8086) 2 x 96 tests)
      eBioscience FlowRNA Probe Sets
           
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