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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL8 Gene

protein-coding   GIFtS: 71
GCID: GC04P074595

interleukin 8
 Explore 434 diseases affiliated with
IL8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IL8    

Aliases
for IL8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interleukin 81 2     K601
CXCL81 2 3     SCYB81
GCP-11 2 3     TSG-11
MDNCF1 2 3     B-ENAP1
MONAP1 2 3     Alveolar Macrophage Chemotactic Factor I2
NAP-11 2 3     Beta Endothelial Cell-Derived Neutrophil Activating Peptide2
GCP11 2     Beta-Thromboglobulin-Like Protein2
LECT1 2     Chemokine (C-X-C Motif) Ligand 82
LUCT1 2     Emoctakin3
LYNAP1 2     Interleukin-81
NAF1 2     Lung Giant Cell Carcinoma-Derived Chemotactic Protein2
NAP11 2     Lymphocyte Derived Neutrophil Activating Peptide2
IL-81 3     Neutrophil-Activating Peptide 12
Granulocyte Chemotactic Protein 12 3     Small Inducible Cytokine Subfamily B, Member 82
Monocyte-Derived Neutrophil Chemotactic Factor2 3     Tumor Necrosis Factor-Induced Gene 12
Monocyte-Derived Neutrophil-Activating Peptide2 3     Emoctakin3
T-Cell Chemotactic Factor2 3     C-X-C Motif Chemokine 83
3-10C1     Neutrophil-Activating Protein 13
AMCF-I1     Protein 3-10C3

External Ids:    HGNC: 60251   Entrez Gene: 35762   Ensembl: ENSG000001694297   OMIM: 1469305   UniProtKB: P101453   

Export aliases for IL8 gene to outside databases

Previous GC identifers: GC04P074845 GC04P075006 GC04P075072 GC04P074971 GC04P070417


Summaries
for IL8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IL8:
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators
of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and
is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a
common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene
family form a chemokine gene cluster in a region mapped to chromosome 4q. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL8_HUMAN, P10145
Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also
involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus.
IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil
activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively

Gene Wiki entry for IL8 (Interleukin 8)


Genomic Views
for IL8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL8 gene promoter:
         GR   AML1a   HNF-4alpha2   NF-E2 p45   HNF-4alpha1   C/EBPalpha   GR-alpha   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL8 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13-q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13-q21

IL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL8 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074595:  view genomic region     (about GC identifiers)

Start:
 74,606,223 bp from pter      End:
 74,609,433 bp from pter
Size:
 3,211 bases      Orientation:
 plus strand

Proteins
for IL8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IL8_HUMAN, P10145 (See protein sequence)
Recommended Name: Interleukin-8 precursor  
Size: 99 amino acids; 11098 Da
Subunit: Homodimer
Subcellular location: Secreted
6/10 PDB 3D structures from and Proteopedia for IL8 (see all 10):
1ICW (3D)        1IKL (3D)        1IKM (3D)        1IL8 (3D)        1ILP (3D)        1ILQ (3D)    
Secondary accessions: B2R4L8 Q6FGF6 Q6LAE6 Q96RG6 Q9C077 Q9UCE1 Q9UCR8 Q9UCR9 Q9UCS0
Alternative splicing: 2 isoforms:  P10145-1   P10145-2   

Explore the universe of human proteins at neXtProt for IL8: NX_P10145

Post-translational modifications:

  • Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood
    • monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is
    the most promiment form1
  • Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly
    • through impaired chemokine clearance from the blood circulation1
  • View neXtProt modification sites for NX_P10145

    • IL8 Protein expression data from MOPED and PaxDb:    About this image 
    IL8 Protein Expression
    REFSEQ proteins: NP_000575.1  
    ENSEMBL proteins: 
     ENSP00000306512   ENSP00000385908  
    Reactome Protein details: P10145
    Human Recombinant Protein Products for IL8: 
    EMD Millipore Purified and/or Recombinant IL8 Protein
    R&D Systems Recombinant & Natural Proteins for IL8 (CXCL8/IL-8)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: IL8
    OriGene Protein Over-expression Lysate: IL8
    OriGene Custom Protein Services for IL8 
    GenScript Purified and Recombinant Proteins for IL8
    Novus Biologicals IL8 Proteins
    Novus Biologicals IL8 Lysates
    Sino Biological Recombinant Protein for IL8
    ProSpec Recombinant Protein for IL8
    Uscn Proteins for IL8

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005622intracellular ----

    IL8 for ontologies           About GeneDecksing



    IL8 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL8
    R&D Systems Antibodies for IL8 (CXCL8/IL-8)
    Cell Signaling Technology (CST) Antibodies for IL8 
    OriGene Antibodies (see all 3): IL8
    OriGene Custom Antibody Services for IL8 
    GenScript Superior Antibodies for IL8
    Novus Biologicals IL8 Antibodies
    Abcam antibodies for IL8 
    Uscn Antibodies for IL8
    ThermoFisher Antibody for IL8

    Assay Products for IL8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Flow Cytometry Kits for IL8 (CXCL8/IL-8)         (see first)
    R&D Systems ELISAs for IL8 (CXCL8/IL-8)
    R&D Systems ELISpot Kits & Development Modules for IL8 (CXCL8/IL-8)
    R&D Systems Multiplex/Array Assay Kits & Reagents for IL8 (CXCL8/IL-8)
    See all other biochemical assays at R&D Systems
    GenScript Custom Assay Services for IL8
    Cell Signaling Technology (CST) Sandwich ELISA Kits for IL8
    Enzo Life Sciences assays for IL8
    Uscn ELISAs and CLIAs for IL8

    Protein Domains /
    Families
    for IL8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IL8 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS
     IPR027206 IL8
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P10145

    ProtoNet protein and cluster: P10145

    1 Blocks protein family: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: IL8_HUMAN, P10145
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Function
    for IL8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL8_HUMAN, P10145
    Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also
    involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus.
    IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil
    activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively
    Induction: By ER stress in a DDIT3/CHOP-dependent manner

         Genatlas biochemistry entry for IL8:
    interleukin 8 (see IMC2@),neutrophil activating peptide 1,monocyte-derived neutrophil chemotactic factor,with a direct
    growth potentiating activity in malignant mesothelioma

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005153interleukin-8 receptor binding IPI1840701
    GO:0005515protein binding IPI10880251
    GO:0008009chemokine activity IEA--
         
    IL8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IL8:
     Increased cell death in breast  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Il8):
     hematopoietic system  immune system 

    IL8 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Il8tm1Lira for IL8
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IL8 

    miRNA
    Products:            		miRTarBase miRNAs that target IL8:
    hsa-mir-146a (MIRT004409), hsa-mir-204 (MIRT005832)

    OriGene 3'-UTR Clone: IL8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL8
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate IL8 (see all 33):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-372 hsa-miR-93 hsa-miR-889 hsa-miR-302b
    SwitchGear 3'UTR luciferase reporter plasmid: IL8 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL8
    OriGene shRNA RFP: IL8
    OriGene siRNA: IL8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL8
    Sirion Biotech Custom design and validation of potent shRNA sequences against IL8 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IL8
    Sirion Biotech Customized adenovirus for overexpression of IL8 
    Sirion Biotech Customized adenovirus for potent knockdown of IL8

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL8
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IL8 (NM_000584)
    Sino Biological Human cDNA Clone for IL8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL8 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IL8
    Search LifeMap BioReagents cell lines for IL8
    Sirion Biotech Customized stable knockdown cell line services for IL8 
    Sirion Biotech Customized inducible knockdown cell line services for IL8
    Sirion Biotech Customized stable overexpressing cell line services for IL8
    Sirion Biotech Customized inducible overexpressing cell line services for IL8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL8


    Pathways & Interactions
    for IL8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/52 super-pathways (see all 52) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/12 pathways (see all 12)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    2TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		Regulation of eIF4 and p70S6K0.43
    		MAPK Family Pathway0.60
    		SOCS Pathway0.29
    		JAK-STAT Pathway0.57
    3Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    		G alpha (i) signalling events0.44
    4Toll-like receptor signaling pathway
    		Toll-like receptor signaling pathway1.00
    		Toll-Like receptor Signaling Pathways0.51
    		Toll-like receptor signaling pathway0.97
    		Chagas disease (American trypanosomiasis)0.31
    5Mucin expression in CF via IL-6, IL-17 signaling pathways
    		Cytokine production by Th17 cells in CF0.45
    		Immune response_MIF-mediated glucocorticoid regulation0.28
    		Cytokine production by Th17 cells in CF (Mouse model)0.37
    		Immune response MIF-mediated glucocorticoid regulation0.28

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/8 EMD Millipore Pathways for IL8 (see all 8)
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Role of integrins in NK cells cytotoxicity
    Selected targets of GCR-alpha
    Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response

    1 R&D Systems Pathway for IL8
        Toll-Like receptor Signaling Pathways

    5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL8 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling

    1 Cell Signaling Technology (CST) Pathway for IL8
        Lymphocyte Signaling

    5/14 GeneGo (Thomson Reuters) Pathways for IL8 (see all 14)
        Immune response MIF-mediated glucocorticoid regulation
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Immune response TLR signaling pathways
    Apoptosis and survival Lymphotoxin-beta receptor signaling

    5/13 BioSystems Pathways for IL8 (see all 13) 
        SIDS Susceptibility Pathways
    EBV LMP1 signaling
    Senescence and Autophagy
    TSLP Signaling Pathway
    Toll-like receptor signaling pathway

    5/13        Reactome Pathways for IL8 (see all 13)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)


    5/16         Kegg Pathways  (Kegg details for IL8) (see all 16):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway
    RIG-I-like receptor signaling pathway


    IL8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/93 Interacting proteins for IL8 (P101453 ENSP000003065124) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PF4P027763, ENSP000002960294I2D: score=3 STRING: ENSP00000296029
    MTDHQ86UE43, ENSP000003382354I2D: score=1 STRING: ENSP00000338235
    RPS3P233963, ENSP000002785724I2D: score=1 STRING: ENSP00000278572
    CXCR2P250253, ENSP000003196354I2D: score=4 STRING: ENSP00000319635
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis TAS11483765
    GO:0002237response to molecule of bacterial origin IDA19912257
    GO:0006928cellular component movement TAS10820279
    GO:0006954inflammatory response TAS11483765
    GO:0006955immune response IEA--

    IL8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IL8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL8

    2 HMDB Compounds for IL8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Salbutamol(l)-albuterol (see all 97)18559-94-9--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--
    10/138 Novoseek chemical compound relationships for IL8 gene (see all 138)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 92.7 1369 9723955 (8), 17207890 (7), 10619832 (7), 16413378 (6) (see all 99)
    groalpha 86.1 191 11495082 (7), 9641651 (7), 17922696 (5), 9889409 (4) (see all 81)
    fmlp 79.7 471 7837814 (9), 16249234 (7), 15494208 (5), 9013980 (5) (see all 99)
    leukotriene b4 78.5 560 8003341 (9), 8973284 (5), 9482389 (5), 12149532 (5) (see all 99)
    vegf 76.4 1297 11234901 (9), 10334214 (9), 17349553 (8), 9457313 (8) (see all 99)
    endotoxin 74.4 268 2007851 (5), 11451261 (5), 18485432 (4), 16384605 (4) (see all 99)
    grogamma 72.8 23 8702798 (3), 15832427 (2), 9553055 (2), 10695618 (1) (see all 11)
    grobeta 68 26 10600366 (3), 8702798 (3), 15832427 (2), 9553055 (2) (see all 12)
    il 10 67.4 70 18363812 (4), 9543183 (2), 19723087 (2), 20041183 (2) (see all 56)
    lipoteichoic acid 67.3 89 10570304 (7), 16619004 (4), 8262617 (4), 19250704 (3) (see all 37)

    Search CenterWatch for drugs/clinical trials and news about IL8 

    Transcripts
    for IL8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IL8 gene: 
    NM_000584.3  

    Unigene Cluster for IL8:

    Interleukin 8
    Hs.624  [show with all ESTs]
    Unigene Representative Sequence: NM_000584
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307407(uc003hhe.3) ENST00000401931 ENST00000483500

    miRNA
    Products:             		 OriGene 3'-UTR Clone: IL8
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL8
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate IL8 (see all 33):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-372 hsa-miR-93 hsa-miR-889 hsa-miR-302b
    SwitchGear 3'UTR luciferase reporter plasmid: IL8 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL8
    OriGene shRNA RFP: IL8
    OriGene siRNA: IL8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL8
    Sirion Biotech Custom design and validation of potent shRNA sequences against IL8 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL8
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IL8 (NM_000584)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL8 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IL8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL8

    Additional cDNA sequence: 

    AK131067.1 AK311874.1 BC013615.1 BT007067.1 CR542151.1 M17017.1 M26383.1 Y00787.1 
    Z11686.1 

    23 DOTS entries:

    DT.92451091  DT.452985  DT.121222191  DT.100764374  DT.121222188  DT.100890247  DT.121222199  DT.97822713 
    DT.121222180  DT.100722366  DT.121222165  DT.100890251  DT.92451100  DT.95366903  DT.100890241  DT.100890254 
    DT.121222196  DT.92451094  DT.92451101  DT.100890252  DT.100890257  DT.100890262  DT.92451080 

    756 AceView cDNA sequences (see top 24):

    AA362358 AA381584 CB306060 BX358167 CR601902 AW780211 BE122713 BQ101101 
    AA362192 BQ431044 CA308318 AA381931 CR595357 BM887846 BM055300 AA362139 
    BM955893 BM924085 AA381252 AA362196 CR623683 AA381576 AA381435 BQ051231 
    AA381999 BQ225540 BC013615 AA381699 BU169639 NM_000584 AA381454 CR603686 
    AA381700 BP336876 CA306746 AI634748 BM069584 CD364559 Z11686 AI952442 
    AW662707 CR601533 AA362246 BU159049 AW769268 BQ216454 BG778571 AA381356 
    BI962588 CK904775 AK131067 AA362132 BM907296 BP337922 BM976609 CD367465 
    AW467973 BM126840 BQ219392 BM128212 BI789121 AW662719 AA362357 CR623827 
    AA381715 AV716793 BM069824 BE042737 AA381848 AI697109 BQ932618 BM888479 
    CR600500 BF445462 AA381795 BU153304 BU181108 AA381177 AA381217 AI346866 
    AA381952 AW662358 CA307868 BQ003056 BQ215118 AA381625 AA381914 BQ129279 
    AW273112 AA381891 BQ100994 BU686095 CR542151 BU626699 AA381395 AA381228 
    CB851080 AA381459 AA362188 AW467270 BU158818 CR594973 BQ934851 BU186293 
    BX396678 BX462017 CR619554 CD521032 AA382015 BG500757 AI469266 CD522395 
    AV714235 AA363545 AW510601 BU928380 BG118436 AV714401 BQ225563 CD640895 
    CD521962 CD641077 AV758152 CD639922 M26383 CD641971 CD641906 CD638835 
    CD640748 CD641791 AW337841 AA381456 BT007067 AV755322 BQ100809 AA381813 
    AW075978 BM055022 CD640805 BG426111 CA309273 BU626684 BG058515 AW951160 
    BX398114 AA381577 CD639459 AW272835 BX360446 W40163 AV715130 BV167919 
    CD638340 AA381601 CD638324 AV713897 CD639846 CD638590 CA748621 CD640946 
    CD642096 BE738445 AV715174 AV717657 CD521395 BU571057 BM907331 CD639489 
    AV717919 BX335639 AW059870 BU192445 BG547297 BX413857 CD520204 CD521156 
    CD638307 BX453257 CD522948 CD522119 BE787424 CD521241 CD640296 AV731724 
    CD639989 AA363554 CD639764 CD638384 CD522647 AA381669 CD640943 AV717293 
    BG501199 CD639562 CD639042 CD640872 T11379 CD638465 BU571136 CD638826 
    CD639192 CD639009 CD642073 CD638490 CD522587 AL711111 AW468452 CD638620 
    BQ002827 CD559385 AW604306 BE439515 BM128443 AW272671 BG231552 BM127905 
    AJ227913 BQ214420 BU928438 AA381767 CD641366 AA363540 CD520685 BX429908 
    CD640756 CD641499 BX358166 CD638669 CD638776 BF590498 CD520464 CD366543 
    CD641883 AW615017 BG497712 BU928318 CD640573 CD521486 BU170071 BF218067 
    AV713876 CD520848 BX365367 CD638295 AW613454 BG777366 CD639392 CD522730 
    CD520498 BU169458 W60423 BQ232784 CD521098 AA381592 CD521484 CD520307 
    AA381877 AV716939 W45271 AV717082 CD641085 BQ716911 CD639279 AW272612 
    CD521390 AA381355 CD521047 CD522167 W40425 BE785606 AA381472 CD639749 
    T11309 AI087873 AI473944 BG119142 BE786369 CD520598 BM055206 CD522745 
    CD640504 BI761140 CD638348 CD640466 CD520146 AV716097 CD639152 AW015490 
    AA381679 CD641511 BE786220 BM126584 CD640979 AA362133 BE789993 CD522027 
    BX397623 CD639274 AW188453 BE789962 CD523315 BX337862 CD640965 AV756825 
    CD638843 BQ003603 CD521554 AI355474 BF344351 BU198780 CD640417 CD559271 
    AA381710 CD642140 CD641136 CB135446 CD520193 CD520102 CD522578 CA309072 
    CD640600 CD367072 AA363453 BE439795 BG142154 D82198 W40279 AA361981 
    AA362140 CD641945 CD559347 BE788958 BG570089 CD640180 CD520849 AA381426 
    CD641495 CD522618 CD677897 CA307813 CD641216 CD522485 CA310339 BU928510 
    CD522432 CD559211 AV756788 CD521051 CD642042 BU192427 BG536682 CD522561 
    BQ213671 AV755442 Y00787 BE439924 BG939683 CD522180 CD642138 AI620395 
    AA363550 AI922031 CD638640 CD521797 BM054955 CD639796 CD523419 BU571147 
    CD638543 AV712466 AV714604 BE787019 BU928951 CD639054 CD639446 AV717936 
    AU137355 AA381229 W38334 M17017 CD521672 CD640987 BU928326 CD642080 
    CD521921 CD640018 CD523199 CA426635 BU155256 CD522511 AV763571 CD520623 
    CD639946 CD641845 CD521704 W60450 T11037 W40283 BU928681 CD520642 
    CD641505 CD638940 BG779686 AA362337 CD639519 CD520736 AI310352 CD522329 
    CD641389 CD520568 BE788777 AV716508 BX453256 BU198348 AA381318 CD638283 
    CD641043 CD639297 BG779880 AA360958 CD640984 AW630501 CD559344 CD521692 
    AV714375 BM821180 BU186618 CD523423 AA381618 AA362160 CD520314 CD520394 
    CD559322 BU928338 AI457250 AV717237 CD640143 CD521195 CD521468 CD641300 
    CD520206 AA363596 AA382057 CD521986 CD523281 AV713473 BU928624 CD520237 
    AA381781 D56519 AA381845 CD520997 BU689976 BQ100716 AV716799 BU928535 
    CD521166 CD639644 AI079248 CD520962 CD639351 CA307406 CD367954 AV712859 
    CD559253 CD642041 CD638411 AA381670 CD641376 CD523337 D82254 AV717597 
    BM833252 BU571083 CD520239 BX365368 CD638414 CD521628 CD520889 CD641489 
    BM129086 AA363559 BU929074 AA363599 CD638476 AV712481 CD559240 BG540597 
    BE790166 CD639908 BE785449 CD520975 BF687713 AA381517 AI476632 D83813 
    BU198124 AA381816 W45362 CD639150 CD559326 BF341536 CD523384 AA346136 
    CD639476 CD521987 CF129689 CD640909 CD639157 CD521124 W56111 T27467 
    AA381967 CD640678 AA296403 AW780131 CD559429 AA381897 AA381653 BX339262 
    AV758699 CD638574 BX365124 AW367405 T29157 CD642015 AI380580 BQ129430 
    AW440851 BG117814 AV682988 AV757876 BX335640 D82102 AA381833 BU192223 
    AW591509 CD641107 CD522972 BG057857 BF185796 BE737839 AV714345 CD639952 
    CD642061 AW950718 CD640885 BU199053 BG537689 AA362269 AA381965 AI274317 
    AW631242 AI579895 AA372837 BM924065 CD559381 BF185745 AV757635 T68419 
    CD520294 CD559412 AA363589 AA371394 AV757045 CD640543 AW377023 AA381623 
    AA362270 BU674113 BU656350 AW341742 AW339521 CD522990 CD639837 CD521883 
    AV717063 BV179378 AA362127 CD640422 C01358 AI953422 AV714023 AA102526 
    BU753499 AA374516 D83842 AA381603 BU675962 CD520643 BE004230 AA381992 
    D83848 AA362107 BF219089 AW470168 AA381189 CD520538 T11316 BU674699 
    D82618 W45409 AV755467 AV730264 CD521942 BG661290 BX476182 AV712540 
    CD523216 AA381702 W39356 CD522758 AV716041 BF216476 CD523112 CD523263 
    CD521404 BU679841 W45324 BM969906 CD640468 AI431254 BF216779 BX365125 
    CK904774 BF218599 BF130542 AW959358 BF245850 BF218222 BU674826 BF381993 
    BQ231178 AI569162 T11198 AJ713849 CD609064 AI564251 AA363514 W52491 
    BU674723 BI962664 BM984034 CD640491 AI282685 BM969541 AV712529 AV756916 
    D82218 BU198938 CD640136 D82615 CD521499 CD609065 BF526422 AA381274 
    C05929 CD520531 CD240350 CD640482 AA381806 AV756289 AV716932 CD640830 
    BM128836 AA362187 AA381218 AW951601 T27482 AV757312 AA095727 AV756855 
    BE788563 CD559357 BE138893 AV755680 T68485 CD522090 AA382121 AI475413 
    AW779405 AW627475 CD522245 AJ714367 AA305271 CD522159 BF217309 CD520246 
    AV737712 W52968 BF215685 AV756323 W46290 CD521171 D83837 AF043337 
    AV714638 CD240252 BF382624 BF244683 CD639568 T18459 D83851 AA381309 
    BE787783 CD640894 T10915 BP336068 BF216952 T11140 BF244611 AA380965 
    AA082747 C05902 AV712107 W40401 D83856 BU928762 AV717066 AV755816 
    BF244370 BG778503 CD522001 AW051250 BE787989 AI469815 CD639107 T11145 
    AA304441 AA568576 CD523399 CD521451 C06304 AI375262 BX337861 AI541051 
    AW663238 CD523011 D82132 CD522754 BF030787 BF849216 AJ713411 AV755227 
    CD523252 AW467642 AV711873 BI048823 BF245485 BF219430 BF081482 BQ212818 
    AV758598 T11274 AV758075 BQ212099 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IL8    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
    SP1:                                                
    SP2:                    -                           
    SP3:                                                


    ECgene alternative splicing isoforms for IL8

    Expression
    for IL8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGAAGCACT
    IL8 Expression
    About this image

    IL8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PlacentaChorionic VillusVillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    PlacentaExtravillous Cytotrophoblast LayerExtravillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See IL8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL8

    SOURCE GeneReport for Unigene cluster: Hs.624
        SABiosciences Expression via Pathway-Focused PCR Arrays including IL8 (see all 24): 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IL8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL8
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL8

    Orthologs
    for IL8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IL8 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IL81 interleukin 8 60.76(n)
    52.08(a)    		   396495  NM_205498.1  NP_990829.1 
    lizard
    (Anolis carolinensis)    		 Reptilia IL86
    		 --
    		 42(a)
    		 1 ↔ 1
    		 AAWZ02035874(23277-25185)


    ENSEMBL Gene Tree for IL8 (if available)
    TreeFam Gene Tree for IL8 (if available) 

    Paralogs
    for IL8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL8 gene
    PPBP2  PF42  CXCL12  PF4V12  CXCL62  CXCL32  CXCL52  CXCL22  
    18/25 SIMAP similar genes for IL8 using alignment to 2 protein entries:     IL8_HUMAN (see all proteins) (see all similar genes):
    CXCL6    CXCL5    PPBP    PF4    CXCL1    CXCL2
    CXCL12    CXCL3    PF4V1    CCL8    CCL3L1    CCL3L3
    CCL11    CCL18    CCL5    CXCL13    CXCL10    CCL2

    IL8 for paralogs           About GeneDecksing



    Genomic Variants
    for IL8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/209 NCBI SNPs in IL8 are shown (see all 209)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs22275271,2
    		F--70415950(+) TTTGAT/AGTTGT 1 -- us2k12Minor allele frequency- A:0.02NS 86
    rs76826391,2
    		C,F,A--70416139(+) TTACAT/CAGCAT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs22275291,2
    		C--70416255(+) TAGAAT/CAAACA 1 -- us2k1 tfbs32Minor allele frequency- C:0.01NS 94
    rs22275301,2
    		C--70416537(+) TATCAT/GAAGAA 1 -- us2k12Minor allele frequency- G:0.01NS 94
    rs22275311,2
    		C--70416580(+) AAGACC/TTTTCA 1 -- us2k13Minor allele frequency- T:0.02NS WA 212
    rs22275321,2
    		C,F,O,H--70417016(+) ATTAAT/CGTCTT 1 -- us2k120Minor allele frequency- C:0.06NS NA WA 2104
    rs22275341,2
    		C,F,H--70417466(+) GTCACA/GTGGTA 1 -- us2k111Minor allele frequency- G:0.00NS EA MN 904
    rs22275351,2
    		C--70417592(+) CTTTCG/ATCATA 1 -- us2k12Minor allele frequency- A:0.01NS 88
    rs414583461,2
    		C--70417690(+) TCCTCT/CGACAT 1 -- us2k11Minor allele frequency- C:0.04NA 46
    rs2019521191,2
    		C--70417752(+) GCCACC/TGGAGC 1 -- ut511Minor allele frequency- T:0.00EU 593

    HapMap Linkage Disequilibrium report for IL8 (74606223 - 74609433 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IL8: --
    Human Gene Mutation Database (HGMD): IL8

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL8
    DNA2.0 Custom Variant and Variant Library Synthesis for IL8

    Disorders / Diseases
    for IL8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IL8 for disorders           About GeneDecksing

    OMIM gene information: 146930    OMIM disorders: --

    20/434 diseases for IL8 (see all 434):    About MalaCards
    lung giant cell carcinoma    neutrophil-specific granule deficiency    bronchiolitis    specific granule deficiency
    erythema elevatum diutinum    muckle-wells syndrome    alpha 1-antitrypsin deficiency    estrogen-receptor negative breast cancer
    stenotrophomonas maltophilia    zollinger-ellison syndrome    glycogen storage disease type ia    large granular lymphocyte leukemia
    adult-onset still's disease    relapsing-remitting multiple sclerosis    extrinsic allergic alveolitis    cryptogenic organizing pneumonia
    common cold    diffuse large b-cell lymphoma    mycobacterium marinum    hypersensitivity reaction type ii disease

    13 diseases from the University of Copenhagen DISEASES database for IL8:
    Lung disease     Cancer     Gastritis     Cystic fibrosis
    Vascular disease     Periodontitis     Chorioamnionitis     Inflammatory bowel disease
    Arthritis     Mastitis     Endometriosis     Psoriasis
    Peptic ulcer

    10/98 Novoseek disease relationships for IL8 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 91.7 3968 9462219 (9), 8601968 (6), 10740342 (5), 1702929 (4) (see all 99)
    inflammation 90.2 1154 12697917 (4), 10680520 (4), 15104334 (4), 15901266 (4) (see all 99)
    tumors 81.8 3953 11181444 (8), 8601968 (6), 12471616 (6), 16088182 (5) (see all 99)
    bronchoalveolar lavage fluid 72.9 158 7712280 (4), 10933164 (3), 16077402 (3), 15909061 (3) (see all 99)
    systemic inflammatory response syndrome 70.3 31 8143477 (2), 9558403 (2), 9038289 (2), 16227031 (2) (see all 21)
    pulmonary disease chronic obstructive 68 39 8563494 (2), 12915744 (2), 11108181 (2), 16181530 (2) (see all 27)
    sepsis 66.2 233 1612748 (6), 17368039 (5), 15730597 (5), 9120108 (4) (see all 99)
    cystic fibrosis 65.2 102 7940424 (6), 7639556 (3), 8476069 (3), 17880760 (2) (see all 65)
    rheumatoid arthritis 64.5 130 1932367 (2), 8961381 (2), 14750259 (2), 10437780 (2) (see all 94)
    airways disease 63.8 23 7927669 (2), 10417151 (1), 10460760 (1), 9199432 (1) (see all 14)

    Genetic Association Database (GAD): IL8
    Human Genome Epidemiology (HuGE) Navigator: IL8 (282 documents)

    Export disorders for IL8 gene to outside databases

    Publications
    for IL8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL8 gene, integrated from 9 sources (see all 7102):
    (articles sorted by number of sources associating them with IL8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The neutrophil-activating proteins interleukin 8 and beta- thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. (PubMed id 2145175)1, 2, 9 van Damme J.... Billiau A. (1990)
    2. Polymorphisms of the IL-8 and CXCR2 genes are not associated with Behcet's disease. (PubMed id 15630732)1, 4, 9 Duymaz-Tozkir J....Gul A. (2005)
    3. Genetic variation in the interleukin-8 gene promoter and vaginal concentrations of interleukin-8 are not associated with bacterial vaginosis during pregnancy. (PubMed id 16038986)1, 4, 9 Diaz-Cueto L....Arechavaleta-Velasco F. (2005)
    4. Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers. (PubMed id 15902922)1, 4, 9 Gonzalez-Quintela A....Perez L.F. (2004)
    5. Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. (PubMed id 15356575)1, 4, 9 Heinzmann A....Deichmann K.A. (2004)
    6. Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. (PubMed id 15708897)1, 4, 9 Kawahara C....Loughlin J. (2005)
    7. Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis. (PubMed id 15917409)1, 4, 9 Howell W.M....Bateman A.C. (2005)
    8. Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. (PubMed id 16284368)1, 4, 9 Taguchi A....Goto H. (2005)
    9. Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma. (PubMed id 15598788)1, 4, 9 Savage S.A....Chanock S.J. (2004)
    10. Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis. (PubMed id 12415593)1, 4, 9 Amoli M.M....Gonzalez-Gay M.A. (2002)

    External Searches for IL8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IL8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3576 HGNC: 6025 AceView: IL8 Ensembl:ENSG00000169429 euGenes: HUgn3576
    ECgene: IL8 Kegg: 3576 H-InvDB: IL8

    Other Databases showing IL8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IL8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL8 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_8
    SeattleSNPshttp://pga.gs.washington.edu/data/il8/

    Intellectual Property
    for IL8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IL8 gene:
    Search GeneIP for patents involving IL8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IL8 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of IL8
     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant IL8 Protein
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     OriGene Antibodies for IL8   OriGene shRNA RFP for IL8  
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     OriGene siRNA for IL8   OriGene 3'-UTR Clone for IL8  
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL8
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL8
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     GenScript Purified and Recombinant Proteins for IL8 GenScript cDNA clones with any tag delivered in your preferred vector for IL8
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     Antibodies & Assays for IL8 

     Regulatory tfbs in IL8 promoter
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     Abcam protocols and scientific support
     Recombinant Protein for IL8




     IL8 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for IL8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL8
     SwitchGear 3'UTR luciferase reporter plasmids for IL8
     SwitchGear Promoter luciferase reporter plasmids for IL8
     ThermoFisher Antibody for IL8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL8
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IL8
    Sirion Biotech Customized:
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     design and validation of potent shRNA sequences against IL8
     adenovirus for potent knockdown of IL8
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     stable overexpressing cell line services for IL8
     inducible overexpressing cell line services for IL8
           
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