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IL8 Gene

protein-coding   GIFtS: 67
GCID: GC04P074595

Interleukin 8

  See IL8-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Interleukin 81 2     T-Cell Chemotactic Factor2 3
Granulocyte Chemotactic Protein 11 2 3     GCP12
Monocyte-Derived Neutrophil Chemotactic Factor1 2 3     LECT2
Monocyte-Derived Neutrophil-Activating Peptide1 2 3     LUCT2
Alveolar Macrophage Chemotactic Factor I1 2     LYNAP2
Beta Endothelial Cell-Derived Neutrophil Activating Peptide1 2     NAF2
Chemokine (C-X-C Motif) Ligand 81 2     NAP12
Lung Giant Cell Carcinoma-Derived Chemotactic Protein1 2     Beta-Thromboglobulin-Like Protein2
Lymphocyte Derived Neutrophil Activating Peptide1 2     emoctakin2
Neutrophil-Activating Peptide 11 2     interleukin-82
Tumor Necrosis Factor-Induced Gene 11 2     Small Inducible Cytokine Subfamily B, Member 82
CXCL82 3     Emoctakin3
GCP-12 3     IL-83
MDNCF2 3     C-X-C Motif Chemokine 83
MONAP2 3     Neutrophil-Activating Protein 13
NAP-12 3     Protein 3-10C3

External Ids:    HGNC: 60251   Entrez Gene: 35762   Ensembl: ENSG000001694297   OMIM: 1469305   UniProtKB: P101453   

Export aliases for IL8 gene to outside databases

Previous GC identifiers: GC04P074845 GC04P075006 GC04P075072 GC04P074971 GC04P070417

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL8 Gene:
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major
mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a
chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis
of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members
of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. (provided by
RefSeq, Jul 2008)

GeneCards Summary for IL8 Gene:
IL8 (interleukin 8) is a protein-coding gene. Diseases associated with IL8 include mycobacterium marinum, and lung giant cell carcinoma. GO annotations related to this gene include interleukin-8 receptor binding and chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: IL8_HUMAN, P10145
Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is
also involved in neutrophil activation. It is released from several cell types in response to an inflammatory
stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity
on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to
IL-8(1-77), respectively

Gene Wiki entry for IL8 (Interleukin 8) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL8 gene promoter:
         GR   AML1a   HNF-4alpha2   NF-E2 p45   HNF-4alpha1   C/EBPalpha   GR-alpha   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL8 promoter sequence
   Search Chromatin IP Primers for IL8

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13-q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13-q21

IL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL8 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074595:  view genomic region     (about GC identifiers)

74,606,223 bp from pter      End:
74,609,433 bp from pter
3,211 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: IL8_HUMAN, P10145 (See protein sequence)
Recommended Name: Interleukin-8 precursor  
Size: 99 amino acids; 11098 Da
Subunit: Homodimer
Selected PDB 3D structures from and Proteopedia for IL8 (see all 10):
1ICW (3D)        1IKL (3D)        1IKM (3D)        1IL8 (3D)        1ILP (3D)        1ILQ (3D)    
Secondary accessions: B2R4L8 Q6FGF6 Q6LAE6 Q96RG6 Q9C077 Q9UCE1 Q9UCR8 Q9UCR9 Q9UCS0
Alternative splicing: 2 isoforms:  P10145-1   P10145-2   

Explore the universe of human proteins at neXtProt for IL8: NX_P10145

Explore proteomics data for IL8 at MOPED

Post-translational modifications: 

  • Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral
    blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8.
    IL-8(6-77) is the most promiment form1
  • Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis,
    possibly through impaired chemokine clearance from the blood circulation1
  • Modification sites at neXtProt

  • See IL8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000575.1  
    ENSEMBL proteins: 
     ENSP00000306512   ENSP00000385908  
    Reactome Protein details: P10145

    IL8 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IL8 Protein
    R&D Systems Recombinant & Natural Proteins for IL8 (CXCL8/IL-8)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IL8
    OriGene Protein Over-expression Lysate for IL8
    OriGene MassSpec for IL8
    OriGene Custom Protein Services for IL8
    GenScript Purified and Recombinant Proteins for IL8
    Novus Biologicals IL8 Proteins
    Novus Biologicals IL8 Lysates
    Sino Biological Recombinant Protein for IL8
    Sino Biological Cell Lysate for IL8
    ProSpec Recombinant Protein for IL8
    Cloud-Clone Corp. Proteins for IL8

    eBioscience Proteins for IL8: (see all 3
                        Human IL-8 Recombinant Protein Carrier-Free 100 ug

    antibodies-online proteins for IL8 (130 products) 

    antibodies-online peptides for IL8

    GeneTex Proteins for IL8: (see all 2
                        IL-8 Recombinant Protein (Active) (GTX48421-PRO)

    IL8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL8
    R&D Systems Antibodies for IL8 (CXCL8/IL-8)
    OriGene Antibodies for IL8
    OriGene Custom Antibody Services for IL8
    Novus Biologicals IL8 Antibodies
    Abcam antibodies for IL8
    Cloud-Clone Corp. Antibodies for IL8
    ThermoFisher Antibody for IL8
    antibodies-online antibodies for IL8 (356 products) 

    GeneTex Antibodies for IL8:  
                        CXCL8 Antibodies

    IL8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL8
    R&D Systems Flow Cytometry Kits for IL8 (CXCL8/IL-8)         (see first)
    R&D Systems ELISAs for IL8 (CXCL8/IL-8)
    R&D Systems ELISpot/FluoroSpot Kits & Development Modules for IL8 (CXCL8/IL-8)
    R&D Systems Luminex Assays for IL8 (CXCL8/IL-8)
    R&D Systems Proteome Profiler Antibody Arrays for IL8 (CXCL8/IL-8)
    See all other biochemical assays at R&D Systems
    GenScript Custom Assay Services for IL8
    Enzo Life Sciences assays for IL8
    Cloud-Clone Corp. ELISAs for IL8
    Cloud-Clone Corp. CLIAs for IL8
    eBioscience ELISAs for IL8: (see all 7
                        Human IL-8 ELISA Ready-SET-Go! (To Be Discontinued. Refer to 2nd Generation RSG Version: cat. 88-8086) 2 x 96 tests
    antibodies-online kits for IL8 (94 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    4 InterPro protein domains:
     IPR028469 Interleukin-8
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P10145

    ProtoNet protein and cluster: P10145

    1 Blocks protein domain: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: IL8_HUMAN, P10145
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family

    Find genes that share domains with IL8           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL8_HUMAN, P10145
    Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is
    also involved in neutrophil activation. It is released from several cell types in response to an inflammatory
    stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity
    on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to
    IL-8(1-77), respectively
    Induction: By ER stress in a DDIT3/CHOP-dependent manner

         Genatlas biochemistry entry for IL8:
    interleukin 8 (see IMC2@),neutrophil activating peptide 1,monocyte-derived neutrophil chemotactic factor,with a
    direct growth potentiating activity in malignant mesothelioma

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005153interleukin-8 receptor binding IPI1840701
    GO:0005515protein binding IPI10880251
    GO:0008009chemokine activity TAS12782716
    Find genes that share ontologies with IL8           About GenesLikeMe

         2 GenomeRNAi human phenotypes for IL8:
     Increased cell death in breast  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il8):
     hematopoietic system  immune system 

    Find genes that share phenotypes with IL8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cxcl15tm1Lira for IL8

       genOway: Develop your customized and physiologically relevant rodent model for IL8

        Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for IL8

    miRTarBase miRNAs that target IL8:
    hsa-mir-146a-5p (MIRT004409), hsa-mir-124-3p (MIRT023079), hsa-mir-155-5p (MIRT020979), hsa-mir-204-5p (MIRT005832), hsa-mir-1 (MIRT024086), hsa-mir-335-5p (MIRT019032)

    Block miRNA regulation of human, mouse, rat IL8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL8 (see all 33):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-372 hsa-miR-93 hsa-miR-889 hsa-miR-302b
    SwitchGear 3'UTR luciferase reporter plasmidIL8 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for IL8
    Predesigned siRNA for gene silencing in human, mouse, rat IL8

    OriGene clones in human, mouse for IL8 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL8 (NM_000584)
    Sino Biological Human cDNA Clone for IL8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL8
    Addgene plasmids for IL8 

    Cell Line
    GenScript Custom overexpressing Cell Line Services for IL8
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL8 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL8

    Flow Cytometry

    eBioscience FlowRNA Probe Sets ( VA1-13103 VA4-13193 VA6-13192) for IL8 

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    IL8_HUMAN, P10145: Secreted
    Subcellular locations from COMPARTMENTS: 

    plasma membrane2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IL8           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for IL8 About   (see all 55)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    Regulation of toll-like receptor signaling pathway0.93
    3NOD-like Receptor Signaling Pathways
    NOD-like Receptor Signaling Pathways0.58
    Immune response IL-1 signaling pathway0.41
    Toll-Like receptor Signaling Pathways0.58
    4Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    5Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33

    Find genes that share SuperPaths with IL8           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for IL8
        NOD-like Receptor Signaling Pathways
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL8 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling

    Selected GeneGo (Thomson Reuters) Pathways for IL8 (see all 14)
        Immune response MIF-mediated glucocorticoid regulation
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Immune response TLR signaling pathways
    Apoptosis and survival Lymphotoxin-beta receptor signaling

    Selected BioSystems Pathways for IL8 (see all 15)
        EBV LMP1 signaling
    Senescence and Autophagy
    SIDS Susceptibility Pathways
    Spinal Cord Injury
    Toll-like receptor signaling pathway

    5 Reactome Pathways for IL8
        Peptide ligand-binding receptors
    Senescence-Associated Secretory Phenotype (SASP)
    Chemokine receptors bind chemokines
    G alpha (i) signalling events
    ATF4 activates genes

    Selected Kegg Pathways  (Kegg details for IL8) (see all 22):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    NF-kappa B signaling pathway
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL8 (see all 24): 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat


        GeneGlobe Interaction Network for IL8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL8 (P101451, 3 ENSP000003065124) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR2P250251, 3, ENSP000003196354EBI-3917999,EBI-2835281 I2D: score=4 STRING: ENSP00000319635
    PF4P027763, ENSP000002960294I2D: score=3 STRING: ENSP00000296029
    MTDHQ86UE43, ENSP000003382354I2D: score=1 STRING: ENSP00000338235
    RPS3P233963, ENSP000002785724I2D: score=1 STRING: ENSP00000278572
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis TAS11483765
    GO:0002237response to molecule of bacterial origin IDA19912257
    GO:0006928cellular component movement TAS10820279
    GO:0006935chemotaxis TAS12782716
    GO:0006954inflammatory response TAS11483765

    Find genes that share ontologies with IL8           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL8

    2 HMDB Compounds for IL8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Salbutamol(l)-albuterol (see all 97)18559-94-9--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    Selected Novoseek inferred chemical compound relationships for IL8 gene (see all 138)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 92.7 1369 9723955 (8), 17207890 (7), 10619832 (7), 16413378 (6) (see all 99)
    groalpha 86.1 191 11495082 (7), 9641651 (7), 17922696 (5), 9889409 (4) (see all 81)
    fmlp 79.7 471 7837814 (9), 16249234 (7), 15494208 (5), 9013980 (5) (see all 99)
    leukotriene b4 78.5 560 8003341 (9), 8973284 (5), 9482389 (5), 12149532 (5) (see all 99)
    vegf 76.4 1297 11234901 (9), 10334214 (9), 17349553 (8), 9457313 (8) (see all 99)
    endotoxin 74.4 268 2007851 (5), 11451261 (5), 18485432 (4), 16384605 (4) (see all 99)
    grogamma 72.8 23 8702798 (3), 15832427 (2), 9553055 (2), 10695618 (1) (see all 11)
    grobeta 68 26 10600366 (3), 8702798 (3), 15832427 (2), 9553055 (2) (see all 12)
    il 10 67.4 70 18363812 (4), 9543183 (2), 19723087 (2), 20041183 (2) (see all 56)
    lipoteichoic acid 67.3 89 10570304 (7), 16619004 (4), 8262617 (4), 19250704 (3) (see all 37)

    Find genes that share compounds with IL8           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for IL8 gene: 

    Unigene Cluster for IL8:

    Interleukin 8
    Hs.624  [show with all ESTs]
    Unigene Representative Sequence: NM_000584
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307407(uc003hhe.3) ENST00000401931 ENST00000483500
    Block miRNA regulation of human, mouse, rat IL8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL8 (see all 33):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-372 hsa-miR-93 hsa-miR-889 hsa-miR-302b
    SwitchGear 3'UTR luciferase reporter plasmidIL8 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for IL8
    Predesigned siRNA for gene silencing in human, mouse, rat IL8
    OriGene clones in human, mouse for IL8 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL8 (NM_000584)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL8
    Addgene plasmids for IL8 
    OriGene qPCR primer pairs and template standards for IL8
    OriGene qSTAR qPCR primer pairs in human, mouse for IL8
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IL8
      QuantiTect SYBR Green Assays in human, mouse, rat IL8
      QuantiFast Probe-based Assays in human, mouse, rat IL8
    Flow Cytometry

    eBioscience FlowRNA Probe Sets ( VA1-13103 VA4-13193 VA6-13192) for IL8 

    Additional mRNA sequence: 

    AK131067.1 AK311874.1 BC013615.1 BT007067.1 CR542151.1 M17017.1 M26383.1 Y00787.1 

    Selected DOTS entries (see all 25):

    DT.92451091  DT.452985  DT.97822713  DT.121222191  DT.100764374  DT.121222188  DT.100890247  DT.121222199 
    DT.121222180  DT.100722366  DT.100890252  DT.121222165  DT.100890251  DT.100890257  DT.92451100  DT.92451101 
    DT.95366903  DT.100691364  DT.100842594  DT.100890241  DT.100890254  DT.121222196  DT.92451080  DT.92451094 

    Selected AceView cDNA sequences (see all 756):

    BM907296 AA362132 BQ101101 CR600500 AI346866 CR619554 AA362358 BU158818 
    BM887846 BM924085 AA381999 BX396678 AA381177 AW662358 AW780211 AA381931 
    CR601533 AA381625 BM128212 CD364559 AW662719 AA381584 BE042737 AW769268 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IL8    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
    SP2:                    -                           

    ECgene alternative splicing isoforms for IL8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    IL8 Expression
    About this image

    IL8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     Mesenchymal Stem Cells
             Placenta-derived mesenchymal stem cells (family)
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Angiogenic cell precursor
             Endothelial-like cells
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
             Angiogenic cell precursor
     Placenta (Extraembryonic Tissues)    fully expand to see all 4 entries
             Villous Cytotrophoblast Cells Chorionic Villus
             Placenta-derived mesenchymal stem cells (family)
    IL8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.624
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL8 (see all 24): 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    OriGene qPCR primer pairs and template standards for IL8
    OriGene qSTAR qPCR primer pairs in human, mouse for IL8
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IL8
    QuantiTect SYBR Green Assays in human, mouse, rat IL8
    QuantiFast Probe-based Assays in human, mouse, rat IL8
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL8 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Il85 chemokine (C-X-C motif) ligand 15   --   5 (44.78 cM) 90794534 
    (Gallus gallus)
    Aves IL86
    Gallus gallus interleukin 8-like 1 (IL8L1), mRNA.
    1 ↔ many
    1 ↔ many
    (Anolis carolinensis)
    Reptilia IL86
    interleukin 8
    1 ↔ 1

    ENSEMBL Gene Tree for IL8 (if available)
    TreeFam Gene Tree for IL8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for IL8 gene
    PPBP2  PF42  CXCL12  PF4V12  CXCL62  CXCL32  CXCL52  CXCL22  
    Selected SIMAP similar genes for IL8 using alignment to 2 protein entries:     IL8_HUMAN (see all proteins) (see all similar genes):
    CXCL6    CXCL5    PPBP    PF4    CXCL1    CXCL2
    CXCL12    CXCL3    PF4V1    CCL8    CCL3L1    CCL3L3
    CCL11    CCL18    CCL5    CXCL13    CXCL10    CCL2

    Find genes that share paralogs with IL8           About GenesLikeMe

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for IL8 (see all 235)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 4 posSequence#AA
    C--70419362(-) ATTCCC/TTTTTT 1 -- int10--------
    --74482423(+) AGCAAA/CGAAAC 1 -- us2k10--------
    C--74482435(+) TGGAGA/TTTTCT 1 -- us2k10--------
    --74482438(+) AGTTTC/TCTTTA 1 -- us2k10--------
    --74482464(+) TTACCA/TATCCG 1 -- us2k10--------
    C--74482562(+) ATTTCA/GTTGTC 1 -- us2k10--------
    F--74482648(+) TTTGAT/AGTTGT 1 -- us2k12Minor allele frequency- A:0.02NS 86
    --74482749(+) TCATCA/GCTGTA 1 -- us2k10--------
    C--74482754(+) ACTGTA/GTTTTA 1 -- us2k10--------
    --74482816(+) TAAGTC/GAGGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL8 (74606223 - 74609433 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IL8: --
    Human Gene Mutation Database (HGMD): IL8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 146930    OMIM disorders: --

    Selected diseases for IL8 (see all 72):    
    About MalaCards
    mycobacterium marinum    lung giant cell carcinoma    bronchiolitis    sepsis
    meningitis    pneumonia    spermatocele    crohn's colitis
    chorioamnionitis    alcoholic hepatitis    cystic fibrosis    common cold
    adult respiratory distress syndrome    aseptic meningitis    cryptogenic organizing pneumonia    bagassosis
    recurrent corneal erosion    funisitis    opisthorchiasis    sinusitis

    13 inferred disease relationships from the University of Copenhagen DISEASES database for IL8:
    Lung disease     Cancer     Gastritis     Cystic fibrosis
    Vascular disease     Periodontitis     Chorioamnionitis     Inflammatory bowel disease
    Arthritis     Mastitis     Psoriasis     Endometriosis
    Peptic ulcer

    Find genes that share disorders with IL8           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL8 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 91.7 3968 9462219 (9), 8601968 (6), 10740342 (5), 1702929 (4) (see all 99)
    inflammation 90.2 1154 12697917 (4), 10680520 (4), 15104334 (4), 15901266 (4) (see all 99)
    tumors 81.8 3953 11181444 (8), 8601968 (6), 12471616 (6), 16088182 (5) (see all 99)
    bronchoalveolar lavage fluid 72.9 158 7712280 (4), 10933164 (3), 16077402 (3), 15909061 (3) (see all 99)
    systemic inflammatory response syndrome 70.3 31 8143477 (2), 9558403 (2), 9038289 (2), 16227031 (2) (see all 21)
    pulmonary disease chronic obstructive 68 39 8563494 (2), 12915744 (2), 11108181 (2), 16181530 (2) (see all 27)
    sepsis 66.2 233 1612748 (6), 17368039 (5), 15730597 (5), 9120108 (4) (see all 99)
    cystic fibrosis 65.2 102 7940424 (6), 7639556 (3), 8476069 (3), 17880760 (2) (see all 65)
    rheumatoid arthritis 64.5 130 1932367 (2), 8961381 (2), 14750259 (2), 10437780 (2) (see all 94)
    airways disease 63.8 23 7927669 (2), 10417151 (1), 10460760 (1), 9199432 (1) (see all 14)

    Genetic Association Database (GAD): IL8
    Human Genome Epidemiology (HuGE) Navigator: IL8 (282 documents)

    Export disorders for IL8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL8 gene, integrated from 10 sources (see all 7249) (see top 10):
    (articles sorted by number of sources associating them with IL8)

    1. The neutrophil-activating proteins interleukin 8 and beta- thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. (PubMed id 2145175)1, 2, 9 van Damme J.... Billiau A. (Eur. J. Immunol. 1990)
    2. Polymorphisms of the IL-8 and CXCR2 genes are not associated with BehAset's disease. (PubMed id 15630732)1, 4, 9 Duymaz-Tozkir J....GA1l A. (J. Rheumatol. 2005)
    3. Lack of association of interleukin-6 and interleukin-8 gene polymorphisms in Chinese patients with systemic lupus erythematosus. (PubMed id 17115422)1, 4, 9 Huang C.M....Tsai F.J. (J. Clin. Lab. Anal. 2006)
    4. Polymorphisms in interleukin 8 and its receptors (IL8, IL8RA and IL8RB) and association of common IL8 receptor variants with peripheral blood eosinophil counts. (PubMed id 16897191)1, 4, 9 Cheong H.S....Park C.S. (J. Hum. Genet. 2006)
    5. Genetic variation in the interleukin-8 gene promoter and vaginal concentrations of interleukin-8 are not associated with bacterial vaginosis during pregnancy. (PubMed id 16038986)1, 4, 9 Diaz-Cueto L....Arechavaleta-Velasco F. (J. Reprod. Immunol. 2005)
    6. Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers. (PubMed id 15902922)1, 4, 9 GonzA!lez-Quintela A....Perez L.F. (Alcohol 2004)
    7. The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea. (PubMed id 19077731)1, 4, 9 Kang J.M....Song I.S. (J. Clin. Gastroenterol. 2009)
    8. Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. (PubMed id 16719905)1, 4, 9 SA!nchez E....Koeleman B.P. (BMC Med. Genet. 2006)
    9. Association of interleukin-8 with cachexia from patients with low-third gastric cancer. (PubMed id 20037740)1, 4, 9 Song B....Wang X. (Comp. Funct. Genomics 2009)
    10. T-251A polymorphism of IL-8 relating to the development of histological gastritis and G-308A polymorphism of TNF-alpha relating to the development of macroscopic erosion. (PubMed id 18301299)1, 4, 9 Szoke D....Tulassay Z. (amp 2008)
    11. Genetic polymorphisms of interleukin-1B (IL-1B), IL-6, IL-8, and IL-10 and risk of prostate cancer. (PubMed id 16618781)1, 4, 9 Michaud D.S....Hayes R.B. (Cancer Res. 2006)
    12. Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. (PubMed id 15356575)1, 4, 9 Heinzmann A....Deichmann K.A. (J. Allergy Clin. Immunol. 2004)
    13. Influence of IL1B polymorphism on CpG island hypermethylation in Helicobacter pylori-infected gastric cancer. (PubMed id 20405297)1, 4, 9 Yoo E.J....Kang G.H. (Virchows Arch. 2010)
    14. Interleukin (IL)-1beta, IL-1 receptor antagonist, IL-6, IL-8, IL-10, and tumor necrosis factor alpha gene polymorphisms in patients with febrile seizures. (PubMed id 20486195)1, 4, 9 Chou I.C....Tsai F.J. (J. Clin. Lab. Anal. 2010)
    15. Genetic and nongenetic covariates of pain severity in patients with adenocarcinoma of the pancreas: assessing the influence of cytokine genes. (PubMed id 19692203)1, 4, 9 Reyes-Gibby C.C....Spitz M.R. (J Pain Symptom Manage 2009)
    16. Genetic polymorphisms of interleukin 8 and risk of ulcerative colitis in the Chinese population. (PubMed id 19348790)1, 4, 9 Li K....Mao D. ( international journal of clinical chemistry 2009)
    17. Cytokine (IL-6) and chemokine (IL-8) gene polymorphisms among rheumatoid arthritis patients in Taiwan. (PubMed id 18799095)1, 4, 9 Lo S.F....Tsai F.J. (Clin. Exp. Rheumatol. 2008)
    18. Genetic polymorphisms of NOD1 and IL-8, but not polymorphisms of TLR4 genes, are associated with Helicobacter pylori-induced duodenal ulcer and gastritis. (PubMed id 17309748)1, 4, 9 Hofner P....MA!ndi Y. (Helicobacter 2007)
    19. Cytokine gene polymorphisms in bullous pemphigoid in a Chinese population. (PubMed id 16403098)1, 4, 9 Chang Y.T....Tsai S.F. (Br. J. Dermatol. 2006)
    20. IL-8 (-251 A/T) and CXCR2 (+1208 C/T) gene polymorphisms and risk of multiple sclerosis in Iranian patients. (PubMed id 16793206)1, 4, 9 Kamali-Sarvestani E....Vessal M. (Neurosci. Lett. 2006)
    21. Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer. (PubMed id 16937502)1, 4, 9 Theodoropoulos G....Gazouli M. (World J. Gastroenterol. 2006)
    22. Association of IL8, CXCR2 and TNF-alpha polymorphisms and airway disease. (PubMed id 16429233)1, 4, 9 Matheson M.C....Abramson M.J. (J. Hum. Genet. 2006)
    23. Polymorphism in the IL-8 gene, but not in the TLR4 gene, increases the severity of acute pancreatitis. (PubMed id 17124436)1, 4, 9 Hofner P....MA!ndi Y. (Pancreatology 2006)
    24. Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. (PubMed id 15708897)1, 4, 9 Kawahara C....Loughlin J. (Ann. Rheum. Dis. 2005)
    25. Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis. (PubMed id 15917409)1, 4, 9 Howell W.M....Bateman A.C. (J. Clin. Pathol. 2005)
    26. Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. (PubMed id 16284368)1, 4, 9 Taguchi A....Goto H. (amp 2005)
    27. Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma. (PubMed id 15598788)1, 4, 9 Savage S.A....Chanock S.J. (amp 2004)
    28. Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis. (PubMed id 12415593)1, 4, 9 Amoli M.M....Gonzalez-Gay M.A. (J. Rheumatol. 2002)
    29. Association of interleukin-8 gene polymorphism with cachexia from patients with gastric cancer. (PubMed id 19929572)1, 4, 9 Bo S....Xiaobo L. (amp 2010)
    30. Interleukin 8 gene polymorphisms and susceptibility to restenosis after percutaneous coronary intervention. (PubMed id 19404719)1, 4, 9 Vogiatzi K....Spandidos D.A. (J. Thromb. Thrombolysis 2010)
    31. Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. (PubMed id 19760027)1, 4, 9 Tsilidis K.K....Platz E.A. (amp 2009)
    32. Common polymorphisms in interleukin genes (IL4, IL6, IL8 and IL12) are not associated with alcoholic liver disease or alcoholism in Spanish men. (PubMed id 19185507)1, 4, 9 Marcos M....Laso F.J. (Cytokine 2009)
    33. Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion. (PubMed id 19347053)1, 4, 9 Steinbrugger I....Weger M. (Mol. Vis. 2009)
    34. Asthma and genes encoding components of the vitamin D pathway. (PubMed id 19852851)1, 4, 9 BossAc Y....Laprise C. (Respir. Res. 2009)
    35. Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II. (PubMed id 19267370)1, 4, 9 Wang M.H....Platz E.A. (Prostate 2009)
    36. Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China. (PubMed id 18676870)1, 4, 9 Hsing A.W....Chanock S.J. (Cancer Res. 2008)
    37. Interleukin promoter polymorphisms and prognosis in colorectal cancer. (PubMed id 18448485)1, 4, 9 Wilkening S....FAPrsti A. (Carcinogenesis 2008)
    38. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PubMed id 18563170)1, 4, 9 Hillian A.D....Drumm M.L. (Genes Immun. 2008)
    39. Genetic variations in inflammatory mediators influence lung disease progression in cystic fibrosis. (PubMed id 19009622)1, 4, 9 Corvol H....Clement A. (Pediatr. Pulmonol. 2008)
    40. A single nucleotide polymorphism in the matrix metalloproteinase-1 and interleukin-8 gene promoter predicts poor prognosis in tongue cancer. (PubMed id 18276095)1, 4, 9 Shimizu Y....Yoshizaki T. (Auris Nasus Larynx 2008)
    41. Interleukin (IL)-12 receptor beta1 codon 378 G homozygote and allele, but not IL-1 (beta-511 promoter, 3953 exon 5, receptor antagonist), IL-2 114, IL-4-590 intron 3, IL-8 3'-UTR 2767, and IL-18 105, are associated with higher susceptibility to leiomyoma. (PubMed id 17222831)1, 4, 9 Hsieh Y.Y....Tsai F.J. (Fertil. Steril. 2007)
    42. Novel interleukin-4 and interleukin-1 receptor antagonist gene variations associated with non-cardia gastric cancer in Japan: comprehensive analysis of 207 polymorphisms of 11 cytokine genes. (PubMed id 17444864)1, 4, 9 Seno H....Chiba T. (J. Gastroenterol. Hepatol. 2007)
    43. Cytokine genotype and phenotype effects on lung function decline in firefighters. (PubMed id 17351514)1, 4, 9 Josyula A.B....Burgess J.L. (J. Occup. Environ. Med. 2007)
    44. Association between human African trypanosomiasis and the IL6 gene in a Congolese population. (PubMed id 16720107)1, 4, 9 Courtin D....Garcia A. (Infect. Genet. Evol. 2007)
    45. [Association of cytokines genes (ILL, IL1RN, TNF, LTA, IL6, IL8, IL0) polymorphic markers with chronic obstructive pulmonary disease]. (PubMed id 17380888)1, 4, 9 Danilko K.V....Victorova T.V. (Mol. Biol. (Mosk.) 2007)
    46. Genetic polymorphisms in immunoresponse genes TNFA, IL6, IL10, and TLR4 are associated with recurrent acute otitis media. (PubMed id 17908769)1, 4, 9 Emonts M....Sanders E.A. (Pediatrics 2007)
    47. Association of IL-8-251A/T polymorphism with incidence of Acute Respiratory Distress Syndrome (ARDS) and IL-8 synthesis after multiple trauma. (PubMed id 17498967)1, 4, 9 Hildebrand F....Pape H.C. (Cytokine 2007)
    48. Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population. (PubMed id 17355643)1, 4, 9 Huang H.Y....Helzlsouer K.J. (BMC Genet. 2007)
    49. Association of IL-8 (-251)T/A polymorphism with susceptibility to and aggressiveness of nasopharyngeal carcinoma. (PubMed id 17869651)1, 4, 9 Ben Nasr H....Chouchane L. (Hum. Immunol. 2007)
    50. Genetic variation in IL-8 associated with increased risk and poor prognosis of breast carcinoma. (PubMed id 16698420)1, 4, 9 Snoussi K....Chouchane L. (Hum. Immunol. 2006)
    51. Inflammation-related gene polymorphisms and colorectal adenoma. (PubMed id 16775170)1, 4, 9 Gunter M.J....Rothman N. (amp 2006)
    52. Impact of IL8 and IL8-receptor alpha polymorphisms on the genetics of bronchial asthma and severe RSV infections. (PubMed id 16503988)1, 4, 9 Puthothu B....Heinzmann A. (Clin Mol Allergy 2006)
    53. The polymorphism interleukin 8 -251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population. (PubMed id 15710978)1, 4, 9 Ohyauchi M....Shimosegawa T. (Gut 2005)
    54. Common genetic variants in the interleukin-6 and chitotriosidase genes are associated with the risk for serious infection in children undergoing therapy for acute myeloid leukemia. (PubMed id 16107886)1, 4, 9 Lehrnbecher T....Schwabe D. (Leukemia 2005)
    55. Genetic polymorphism of interleukin-8 (IL-8) is associated with Helicobacter pylori-induced duodenal ulcer. (PubMed id 15627645)1, 4, 9 Gyulai Z....MA!ndi Y. (Eur. Cytokine Netw. 2004)
    56. [Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis]. (PubMed id 15220553)1, 4, 9 Kim M.S....Lee M.S. (Korean J Gastroenterol 2004)
    57. Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO- alpha and leaves RANTES and MCP-2 intact. (PubMed id 11023497)1, 2, 9 Van den Steen P.E.... Opdenakker G. (Blood 2000)
    58. Structure and activity of a chimeric interleukin-8-melanoma-growth- stimulatory-activity protein. (PubMed id 8631339)1, 2, 9 Sticht H.... Rosch P. (Eur. J. Biochem. 1996)
    59. Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide. (PubMed id 2007144)1, 2, 9 Clark-Lewis I....Aebersold R. (Biochemistry 1991)
    60. Hodgkin disease risk: role of genetic polymorphisms and gene-gene interactions in inflammation pathway genes. (PubMed id 21061265)1, 4 Monroy C.M....El-Zein R.A. (Mol. Carcinog. 2011)
    61. Association of haplotypes of inflammation-related genes with gastric preneoplastic lesions in African Americans and Caucasians. (PubMed id 20473875)1, 4 Zabaleta J....Ochoa A.C. (Int. J. Cancer 2011)
    62. Combined effects of IL-8 and CXCR2 gene polymorphisms on breast cancer susceptibility and aggressiveness. (PubMed id 20540789)1, 4 Snoussi K....Chouchane L. (BMC Cancer 2010)
    63. Interleukin-8 -251 A/T gene polymorphism and gastric cancer susceptibility: a meta-analysis of epidemiological studies. (PubMed id 20363644)1, 4 Liu L....Zhou Y. (Cytokine 2010)
    64. The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer. (PubMed id 20437058)1, 4 Hawken S.J....Little J. (Hum. Genet. 2010)
    65. Cytokine gene polymorphisms and risk for upper respiratory symptoms in highly-trained athletes. (PubMed id 20839488)1, 4 Cox A.J....Scott R.J. (Exerc Immunol Rev 2010)
    66. IL-1A9 (+3953 C/T) and IL-8 (-251 A/T) gene polymorphisms in H. pylori mediated gastric disorders. (PubMed id 20574123)1, 4 Farshad S....Ranjbar R. (Iran J Immunol 2010)
    67. Interleukin-8-251A/T polymorphism and Helicobacter pylori infection influence risk for the development of gastric cardiac adenocarcinoma in a high-incidence area of China. (PubMed id 20300863)1, 4 Zhang L....Wang S. (Mol. Biol. Rep. 2010)
    68. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    69. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    70. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    71. Influence of interleukin polymorphisms on development of gastric cancer and peptic ulcer. (PubMed id 20222161)1, 4 Sugimoto M....Furuta T. (World J. Gastroenterol. 2010)
    72. Polymorphisms in inflammatory genes, plasma antioxidants, and prostate cancer risk. (PubMed id 20431935)1, 4 Zhang J....Kadlubar F.F. (amp 2010)
    73. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    74. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    75. IL-8 -251A/T polymorphism is associated with decreased cancer risk among population-based studies: evidence from a meta-analysis. (PubMed id 20400292)1, 4 Gao L.B....Zhang L. (Eur. J. Cancer 2010)
    76. Polymorphism of IL-8 in 251 allele and gastric cancer susceptibility: a meta-analysis. (PubMed id 19777350)1, 4 Wang J....He Q. (Dig. Dis. Sci. 2010)
    77. Association of genetic variants, ethnicity and preterm birth with amniotic fluid cytokine concentrations. (PubMed id 20369436)1, 4 Menon R....Williams S.M. (Ann. Hum. Genet. 2010)
    78. Haplotype of IL-8 -251T and 781C is associated with the susceptibility to respiratory syncytial virus. (PubMed id 19887538)1, 4 Lu A....Zhang X. (J. Trop. Pediatr. 2010)
    79. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    80. Inflammatory cytokine gene polymorphisms increase the risk of atrophic gastritis and intestinal metaplasia. (PubMed id 20380014)1, 4 Li Z.W....Li J.Y. (World J. Gastroenterol. 2010)
    81. Joint influences of Acidic-Mammalian-Chitinase with Interleukin-4 and Toll-like receptor-10 with Interleukin-13 in the genetics of asthma. (PubMed id 20444155)1, 4 Heinzmann A....Strauch K. (Pediatr Allergy Immunol 2010)
    82. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    83. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. (PubMed id 20811626)1, 4 Hildebrandt M.A....Wu X. (PLoS ONE 2010)
    84. Associations of plasma IL-8 levels with Helicobacter pylori seropositivity, gastric atrophy, and IL-8 T-251A genotypes. (PubMed id 19719901)1, 4 Naito M....Hamajima N. (Epidemiol. Infect. 2010)
    85. The interleukin-8-251 AA genotype is associated with angiogenesis in gastric carcinogenesis in Helicobacter pylori-infected Koreans. (PubMed id 20621718)1, 4 Song J.H....Song I.S. (Cytokine 2010)
    86. Cytokine genetic polymorphisms and susceptibility to Kawasaki disease in Taiwanese children. (PubMed id 21048327)1, 4 Weng K.P....Ger L.P. (Circ. J. 2010)
    87. Association of haplotypes in the IL8 gene with susceptibility to chronic periodontitis in a Brazilian population. (PubMed id 20488171)1, 4 Kim Y.J....Scarel-Caminaga R.M. ( international journal of clinical chemistry 2010)
    88. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
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    90. Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer. (PubMed id 20418110)1, 4 Erdei E....Berwick M. (Cytokine 2010)
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    93. Clinical relevance of 13 cytokine gene polymorphisms in Chinese major trauma patients. (PubMed id 20217044)1, 4 Gu W....Jiang J.X. (Intensive Care Med 2010)
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    95. The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis. (PubMed id 20207250)1, 4 Davis S.M....Silver R.M. (Am. J. Obstet. Gynecol. 2010)
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    104. Nontuberculous mycobacterial cervicofacial lymphadenitis in children from the multicenter, randomized, controlled trial in The Netherlands: relevance of polymorphisms in candidate host immunity genes. (PubMed id 20399512)1, 4 Haverkamp M.H....van Dissel J.T. (Int. J. Pediatr. Otorhinolaryngol. 2010)
    105. A common polymorphism in the interleukin-8 gene promoter is associated with an increased risk for recurrent Clostridium difficile infection. (PubMed id 21058913)1, 4 Garey K.W....Dupont H.L. (Clin. Infect. Dis. 2010)
    106. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    107. Interleukin 8 -251T&gt;A and Interferon gamma +874A&gt;T polymorphism: potential predictors of allograft outcome in renal transplant recipients from north India. (PubMed id 19189859)1, 4 Singh R....Mittal R.D. (Transpl. Immunol. 2009)
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    114. Association between a pro-inflammatory genetic profile and the risk of chronic atrophic gastritis among older adults from Germany. (PubMed id 19013788)1, 4 Gao L....Brenner H. (Eur. J. Cancer 2009)
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    117. Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women. (PubMed id 19505916)1, 4 Van Dyke A.L....Schwartz A.G. (amp 2009)
    118. Interleukin-8 T-251A polymorphism was associated with positive anti-p53 antibodies in Uzbekistan population. (PubMed id 19994728)1, 4 Okada R....Hamajima N. (Nagoya J Med Sci 2009)
    119. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)1, 4 Dagle J.M....Murray J.C. (Pediatrics 2009)
    120. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    121. Interleukin-10 is associated with resistance to febrile seizures: genetic association and experimental animal studies. (PubMed id 19055487)1, 4 Ishizaki Y....Hara T. (Epilepsia 2009)
    122. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    123. The interleukin-8-251 A allele is associated with increased risk of noncardia gastric adenocarcinoma in Helicobacter pylori-infected Koreans. (PubMed id 18542040)1, 4 Ye B.D....Song I.S. (J. Clin. Gastroenterol. 2009)
    124. Interaction between interleukin-8 and methylenetetrahydrofolate reductase genes modulates Alzheimer's disease risk. (PubMed id 19246914)1, 4 Li K....Yao L. (Dement Geriatr Cogn Disord 2009)
    125. Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians. (PubMed id 20015396)1, 4 Natividad A....Bailey R. (BMC Med. Genet. 2009)
    126. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (amp 2009)
    127. Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer. (PubMed id 19012493)1, 4 Wang S.S....Hildesheim A. (J. Infect. Dis. 2009)
    128. Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians. (PubMed id 19357773)1, 4 Ahluwalia T.S....Singal P.K. (PLoS ONE 2009)
    129. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (Postgrad Med J 2009)
    130. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (Am. J. Obstet. Gynecol. 2009)
    131. The genomic basis of cerebral palsy: a HuGE systematic literature review. (PubMed id 19238444)1, 4 O'Callaghan M.E....Dekker G. (Hum. Genet. 2009)
    132. Inverse association between a pro-inflammatory genetic profile and Helicobacter pylori seropositivity among patients with chronic atrophic gastritis: enhanced elimination of the infection during disease progression? (PubMed id 19427781)1, 4 Gao L....Brenner H. (Eur. J. Cancer 2009)
    133. Citrullination of CXCL8 increases this chemokine's ability to mobilize neutrophils into the blood circulation. (PubMed id 19608678)1, 2 Loos T.... Proost P. (Haematologica 2009)
    134. Polymorphisms in inflammation genes, tobacco smoke and furred pets and wheeze in children. (PubMed id 19674346)1, 4 SA...Raaschou-Nielsen O. (Pediatr Allergy Immunol 2009)
    135. Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. (PubMed id 19066394)1, 4 Colt J.S....Wang S.S. (Blood 2009)
    136. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    137. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    138. Association studies of interleukin-8 gene in Graves' disease and Graves' ophthalmopathy. (PubMed id 19816813)1, 4 Gu L.Q....Ning G. (Endocrine 2009)
    139. Gene expression polymorphisms of interleukins-1 beta, -4, -6, -8, -10, and tumor necrosis factors-alpha, -beta: regression analysis of their effect upon oral squamous cell carcinoma. (PubMed id 18273643)1, 4 Vairaktaris E....Patsouris E. (J. Cancer Res. Clin. Oncol. 2008)
    140. A systematic review of meta-analyses on gene polymorphisms and gastric cancer risk. (PubMed id 19506726)1, 4 Gianfagna F....Boccia S. (Curr. Genomics 2008)
    141. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    142. Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease. (PubMed id 18665932)1, 4 Kim N....Song I.S. (Helicobacter 2008)
    143. IL-1beta and IL-8, matrix metalloproteinase 3, and pepsinogen secretion before and after H. pylori eradication in gastroduodenal phenotypes. (PubMed id 18609140)1, 4 Chang Y.W....Chang R. (Scand. J. Gastroenterol. 2008)
    144. Genetic polymorphism of MCP-1-2518, IL-8-251 and susceptibility to acute pancreatitis: a pilot study in population of Suzhou, China. (PubMed id 18837094)1, 4 Chen W.C. and Nie J.S. (World J. Gastroenterol. 2008)
    145. Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). (PubMed id 18628242)1, 4 Crusius J.B....GonzA!lez C.A. (Ann. Oncol. 2008)
    146. Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke. (PubMed id 18549840)1, 4 Enquobahrie D.A....Psaty B.M. (Am. J. Cardiol. 2008)
    147. Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. (PubMed id 18992148)1, 4 KA1ry S....BAczieau S. (BMC Cancer 2008)
    148. The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population. (PubMed id 18090907)1, 4 Canedo P....Machado J.C. (Eur. J. Cancer Prev. 2008)
    149. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (PLoS ONE 2008)
    150. A pro-inflammatory genotype predisposes to Barrett's esophagus. (PubMed id 18192685)1, 4 Moons L.M....Siersema P.D. (Carcinogenesis 2008)
    151. Association of specific haplotype of TNFalpha with Helicobacter pylori-mediated duodenal ulcer in eastern Indian population. (PubMed id 19147919)1, 4 Chakravorty M....Roychoudhury S. (J. Genet. 2008)
    152. Inflammation-related genes and the risk of Parkinson's disease: a multilocus approach. (PubMed id 18284424)1, 4 Infante J....Combarros O. (Eur. J. Neurol. 2008)
    153. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    154. Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration. (PubMed id 18310311)1, 4 Goverdhan S.V....Lotery A.J. (Br J Ophthalmol 2008)
    155. Influence of interleukin-8 and interleukin-10 on sporadic colon cancer development and progression. (PubMed id 18628251)1, 4 Cacev T....KapitanoviA8 S. (Carcinogenesis 2008)
    156. Interleukin gene polymorphisms in age-related macular degeneration. (PubMed id 18235016)1, 4 Tsai Y.Y....Tseng S.H. (amp 2008)
    157. Interleukin 8 and susceptibility to coronary artery disease: a population genetics perspective. (PubMed id 18385984)1, 4 Vogiatzi K....Spandidos D.A. (J. Clin. Immunol. 2008)
    158. Cytokine gene polymorphisms and susceptibility to chronic irritant contact dermatitis. (PubMed id 18416756)1, 4 de Jongh C.M....Kezic S. (Contact Derm. 2008)
    159. The influence of tumor necrosis factor-alpha -308 G/A and IL-6 -174 G/C on pain and analgesia response in lung cancer patients receiving supportive care. (PubMed id 18990769)1, 4 Reyes-Gibby C.C....Bruera E. (amp 2008)
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    161. Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation. (PubMed id 18710930)1, 2 Proost P.... Van Damme J. (J. Exp. Med. 2008)
    162. IL-6 receptor, IL-8 receptor and TNF-alpha238 (G/A) polymorphisms are not associated with BehAset's disease in patients of German or Turkish origin. (PubMed id 19026125)1, 4 Storz K....KAPtter I. (Clin. Exp. Rheumatol. 2008)
    163. Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era. (PubMed id 18633131)1, 4 Habermann T.M....Cerhan J.R. (Blood 2008)
    164. A report of cytokine polymorphisms and COPD risk in Xuan Wei, China. (PubMed id 17681858)1, 4 Shen M....Lan Q. (Int J Hyg Environ Health 2008)
    165. Polymorphisms in VEGF and IL-8 predict tumor recurrence in stage III colon cancer. (PubMed id 18550579)1, 4 Lurje G....Lenz H.J. (Ann. Oncol. 2008)
    166. Association of cytokine gene polymorphisms with rate of decline in lung function. (PubMed id 18545091)1, 4 Yucesoy B....Burgess J.L. (J. Occup. Environ. Med. 2008)
    167. Candidate genes and cerebral palsy: a population-based study. (PubMed id 18977990)1, 4 Gibson C.S....Nelson K.B. (Pediatrics 2008)
    168. Cytokine gene polymorphisms in Italian preterm infants: association between interleukin-10 -1082 G/A polymorphism and respiratory distress syndrome. (PubMed id 17314689)1, 4 Capasso M....Iolascon A. (Pediatr. Res. 2007)
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    171. Polymorphisms in genes involved in innate immunity predispose toward mycetoma susceptibility. (PubMed id 17709521)1, 4 van de Sande W.W....van Belkum A. (J. Immunol. 2007)
    172. Chronic infections and genetic factors in the development of ischemic stroke. (PubMed id 17802898)1, 4 Kis Z....Gonczol E. (New Microbiol. 2007)
    173. Association of interleukin-8 polymorphism and immunoglobulin G anti-toxin A in patients with Clostridium difficile-associated diarrhea. (PubMed id 17618838)1, 4 Jiang Z.D....DuPont H.L. (Clin. Gastroenterol. Hepatol. 2007)
    174. Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. (PubMed id 17327408)1, 4 Cerhan J.R....Hartge P. (Blood 2007)
    175. Cytokine genes and pain severity in lung cancer: exploring the influence of TNF-alpha-308 G/A IL6-174G/C and IL8-251T/A. (PubMed id 18086782)1, 4 Reyes-Gibby C.C....Shete S. (amp 2007)
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    177. Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract. (PubMed id 17356794)1, 4 Campa D....Canzian F. (amp 2007)
    178. Relevance of transforming growth factor-beta1, interleukin-8, and tumor necrosis factor-alpha polymorphisms in patients with chronic pancreatitis. (PubMed id 17400536)1, 4 Farkas G....MA!ndi Y. (Eur. Cytokine Netw. 2007)
    179. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    180. Frequency of cytokine gene promoter polymorphisms in the Northern Ireland cystic fibrosis population. (PubMed id 17336597)1, 4 Watt A.P....Elborn J.S. (J. Cyst. Fibros. 2007)
    181. Evidence of potential interaction of chemokine genes in susceptibility to systemic sclerosis. (PubMed id 17599774)1, 4 Lee E.B....Song Y.W. (Arthritis Rheum. 2007)
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    185. Association of haplotypes of interleukin-10 gene with the risk of cancer. (PubMed id 18457043)1, 4 Pogoda T.V....Govorun V.M. (Bull. Exp. Biol. Med. 2007)
    186. Association of interleukin-8 (IL-8 or CXCL8) -251T/A and CXCR2 +1208C/T gene polymorphisms with breast cancer. (PubMed id 17949231)1, 4 Kamali-Sarvestani E....Atefi S. (Neoplasma 2007)
    187. Variation of interleukin 8 -251 A&gt;T polymorphism in worldwide populations and intra-ethnic differences in Japanese populations. (PubMed id 17020755)1, 4 Fujihara J....Takeshita H. ( international journal of clinical chemistry 2007)
    188. Peroxisome proliferator-activated [corrected] receptor-gamma2 [corrected] Pro12Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes. (PubMed id 16959787)1, 4 Vogel U....nneland A. (Carcinogenesis 2007)
    189. Interleukin-8 and CXCR1 receptor functional polymorphisms and susceptibility to acute pyelonephritis. (PubMed id 17296422)1, 4 Artifoni L....Murer L. (J. Urol. 2007)
    190. Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -251 polymorphisms in the risk for the development of distal gastric cancer. (PubMed id 17462092)1, 4 Garza-Gonzalez E....Perez-Perez G.I. (BMC Cancer 2007)
    191. Lack of association of IL8 gene polymorphisms with familial vesico-ureteral reflux. (PubMed id 17211588)1, 4 Kuroda S. and Puri P. (Pediatr. Surg. Int. 2007)
    192. Interleukin-8 gene polymorphism associated with susceptibility to non-cardia gastric carcinoma with microsatellite instability. (PubMed id 16824064)1, 4 Shirai K....Goto H. (J. Gastroenterol. Hepatol. 2006)
    193. A common polymorphism in the interleukin 8 gene promoter is associated with Clostridium difficile diarrhea. (PubMed id 16573784)1, 4 Jiang Z.D....LaRocco M. (Am. J. Gastroenterol. 2006)
    194. Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab. (PubMed id 16788380)1, 4 Zhang W....Lenz H.J. (Pharmacogenet. Genomics 2006)
    195. Associations of classic Kaposi sarcoma with common variants in genes that modulate host immunity. (PubMed id 16702372)1, 4 Brown E.E....Chanock S.J. (amp 2006)
    196. H. pylori genotypes and cytokine gene polymorphisms influence the development of gastric intestinal metaplasia in a Chinese population. (PubMed id 16635219)1, 4 Leung W.K....Sung J.J. (Am. J. Gastroenterol. 2006)
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    198. Genetic variation in interleukin 8 and its receptor genes and its influence on the risk and prognosis of prostate cancer among Finnish men in a large cancer prevention trial. (PubMed id 16679868)1, 4 Yang H.P....Tangrea J.A. (Eur. J. Cancer Prev. 2006)
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    201. Differences in inflammatory cytokine and Toll-like receptor genes and bacterial vaginosis in pregnancy. (PubMed id 16202743)1, 4 Goepfert A.R....Langer O. (Am. J. Obstet. Gynecol. 2005)
    202. Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population. (PubMed id 15579481)1, 4 Lu W....You W. (Carcinogenesis 2005)
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    209. Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. (PubMed id 14604894)1, 4 Campa D....Canzian F. (Carcinogenesis 2004)
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    350. IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation. (PubMed id 14530367)1, 9 Merz D....Terkeltaub R. (J. Immunol. 2003)
    351. Bombesin stimulates nuclear factor kappa B activation and expression of proangiogenic factors in prostate cancer cells. (PubMed id 12839933)1, 9 Levine L....Hellmich M.R. (Cancer Res. 2003)
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    354. Immobilized IL-8 triggers progressive activation of neutrophils rolling in vitro on P-selectin and intercellular adhesion molecule-1. (PubMed id 11564821)1, 9 DiVietro J.A....Lawrence M.B. (J. Immunol. 2001)
    355. Role of TLR2 and TLR4 in human neutrophil functions against Paracoccidioides brasiliensis. (PubMed id 20384861)1, 9 Acorci-ValAcrio Campos Soares A.M. (Scand. J. Immunol. 2010)
    356. Disease activity and cytokine production in mitogen-stimulated peripheral blood mononuclear cells from patients with rheumatoid arthritis. (PubMed id 19996617)1, 9 Uppal S.S....Rawoot P. (Med Princ Pract 2010)
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    359. Cepharanthine inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing expression of vascular endothelial growth factor and interleukin-8. (PubMed id 19787256)1, 9 Harada K....Ueyama Y. (Int. J. Oncol. 2009)
    360. IL-17 secreted by tumor reactive T cells induces IL-8 release by human renal cancer cells. (PubMed id 19238009)1, 9 Inozume T....Yang J.C. (J. Immunother. 2009)
    361. Measurement of tumor necrosis factor-alpha, leukotriene B4, and interleukin 8 in the exhaled breath condensate in patients with acute exacerbations of chronic obstructive pulmonary disease. (PubMed id 19436689)1, 9 Ko F.W....Hui D.S. (Int J Chron Obstruct Pulmon Dis 2009)
    362. Effects of peritoneal fluid from endometriosis patients on interferon-gamma-induced protein-10 (CXCL10) and interleukin-8 (CXCL8) released by neutrophils and CD4+ T cells. (PubMed id 19694638)1, 9 Kim J.Y....Lee K.S. (Am. J. Reprod. Immunol. 2009)
    363. Differential flow cytometric detection of intracellular cytokines in peripheral and peritoneal mononuclear cells of women with endometriosis. (PubMed id 17207568)1, 9 Gmyrek G.B....CheA8moA8ska-Soyta A. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2008)
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    365. Prokineticin 1 induces CCL4, CXCL1 and CXCL8 in human monocytes but not in macrophages and dendritic cells. (PubMed id 19103522)1, 9 Monnier J....Samson M. (Eur. Cytokine Netw. 2008)
    366. IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells. (PubMed id 18065201)1, 9 Yang H.T....Rousseau S. (Cell. Signal. 2008)
    367. The potential molecular mechanism of overexpression of uPA, IL-8, MMP-7 and MMP-9 induced by TRAIL in pancreatic cancer cell. (PubMed id 18397859)1, 9 Zhou D.H....Kalthoff H. (amp 2008)
    368. Analysis of interleukin-8, interleukin-10, and tumor necrosis factor-alpha in the cerebrospinal fluid of patients with cervical spondylotic myelopathy. (PubMed id 18391721)1, 9 Ito K....Ishiguro N. (amp 2008)
    369. Cervical fluid cytokines in pregnant women: Relation to vaginal wet mount findings and polymorphonuclear leukocyte counts. (PubMed id 18406509)1, 9 NenadiA8 D.B. and PavloviA8 M.D. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2008)
    370. Involvement of nuclear factor-kappa B in bcl-xL-induced interleukin 8 expression in glioblastoma. (PubMed id 18786178)1, 9 Gabellini C....Del Bufalo D. (J. Neurochem. 2008)
    371. Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock. (PubMed id 18511707)1, 9 Wong H.R....Williams M.D. (Am. J. Respir. Crit. Care Med. 2008)
    372. Increased serum monocyte chemoattractant protein-1, macrophage inflammatory protein-1beta, and interleukin-8 concentrations in hemophagocytic lymphohistiocytosis. (PubMed id 18623207)1, 9 Tamura K....Morikawa A. (amp 2008)
    373. CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells. (PubMed id 17709599)1, 9 Vij N.... Zeitlin P.L. (Am. J. Respir. Cell Mol. Biol. 2008)
    374. Butyrate regulates the expression of pathogen-triggered IL-8 in intestinal epithelia. (PubMed id 17805211)1, 9 Weng M....Sanderson I.R. (Pediatr. Res. 2007)
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    376. Blood leukocyte mRNA expression for IL-10, IL-1Ra, and IL-8, but not IL-6, increases after exercise. (PubMed id 16978071)1, 9 Nieman D.C....McAnulty L.S. (amp 2006)
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    378. Histidine inhibits oxidative stress- and TNF-alpha-induced interleukin-8 secretion in intestinal epithelial cells. (PubMed id 16107255)1, 9 Son D.O....Shimizu M. (FEBS Lett. 2005)
    379. Helicobacter pylori induces interleukin-8 secretion by Toll-like receptor 2- and Toll-like receptor 5-dependent and -independent pathways. (PubMed id 15731050)1, 9 Torok A.M....Goldberg J.B. (Infect. Immun. 2005)
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    382. Cooperative interactions between flagellin and SopE2 in the epithelial interleukin-8 response to Salmonella enterica serovar typhimurium infection. (PubMed id 15321998)1, 9 Huang F.C....Cherayil B.J. (Infect. Immun. 2004)
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    384. Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage. (PubMed id 12909591)1, 9 D'Angio C.T....Finkelstein J.N. (Am. J. Physiol. Lung Cell Mol. Physiol. 2004)
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    386. Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival. (PubMed id 15534087)1, 9 Benoy I.H....Dirix L.Y. (Clin. Cancer Res. 2004)
    387. Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinicopathological features and prognosis. (PubMed id 14676125)1, 9 Ren Y....Fan S.T. (Clin. Cancer Res. 2003)
    388. The primary role in biologic activity of the neutrophil chemokines IL-8 and GRO-alpha in cultured nasal epithelial cells. (PubMed id 12744776)1, 9 Rudack C....Schroeder J.M. (amp 2003)
    389. Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression. (PubMed id 11854210)1, 9 Tamai R....Takada H. (Infect. Immun. 2002)
    390. Protein kinase C and ERK activation are required for TFF-peptide-stimulated bronchial epithelial cell migration and tumor necrosis factor-alpha-induced interleukin-6 (IL-6) and IL-8 secretion. (PubMed id 11884401)1, 9 Graness A....Hoffmann W. (J. Biol. Chem. 2002)
    391. Expression of interleukin-8, heme oxygenase-1 and vascular endothelial growth factor in DLD-1 colon carcinoma cells exposed to pyrrolidine dithiocarbamate. (PubMed id 12151344)1, 9 Hellmuth M....MA1hl H. (Carcinogenesis 2002)
    392. Interleukin-8 and growth-regulated oncogene alpha mediate angiogenesis in Kaposi's sarcoma. (PubMed id 12388718)1, 9 Lane B.R....Markovitz D.M. (J. Virol. 2002)
    393. Autocrine growth effect of IL-8 and GROalpha on a human pancreatic cancer cell line, Capan-1. (PubMed id 10881932)1, 9 Takamori H....Schraufstatter I.U. (Pancreas 2000)
    394. Proinflammatory cytokine IL-1beta stimulates IL-8 synthesis in mast cells via a leukotriene B4 receptor 2-linked pathway, contributing to angiogenesis. (PubMed id 20194723)1, 9 Kim G.Y....Kim J.H. (J. Immunol. 2010)
    395. Lysophosphatidic acid up-regulates expression of growth-regulated oncogene-alpha, interleukin-8, and monocyte chemoattractant protein-1 in human first-trimester trophoblasts: possible roles in angiogenesis and immune regulation. (PubMed id 19906815)1, 9 Chen S.U....Yang Y.S. (Endocrinology 2010)
    396. Neutrophil expression of cyclooxygenase 2 in preeclampsia. (PubMed id 20220108)1, 9 Bachawaty T....Walsh S.W. (Reprod Sci 2010)
    397. Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells. (PubMed id 19460789)1, 9 Gosens R....Zuyderduyn S. (Eur. Respir. J. 2009)
    398. Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis. (PubMed id 18830271)1, 9 Watanabe H....Iijima M. (J. Invest. Dermatol. 2009)
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    401. Serum proinflammatory cytokine - interleukin-8 as possible infection site marker in preterm deliveries. (PubMed id 19591568)1, 9 Bogavac M.A. and BrkiA8 S. (J Perinat Med 2009)
    402. Lipoxin A4 inhibits IL-1beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells. (PubMed id 19357230)1, 9 Decker Y....Godson C. (Am. J. Physiol., Cell Physiol. 2009)
    403. Dynamic changes of interleukin-8 network along the colorectal adenoma-carcinoma sequence. (PubMed id 19350238)1, 9 Cui G....Florholmen J. (Cancer Immunol. Immunother. 2009)
    404. Effect of sulfasalazine on basal and bacteria-stimulated interleukin-8 production by endocervical epithelial cells. (PubMed id 19239421)1, 9 Peltier M.R....Smulian J.C. (Am. J. Reprod. Immunol. 2009)
    405. Role of pro-/anti-inflammatory cytokines and their correlation with established risk factors in South Indians with coronary artery disease. (PubMed id 18796448)1, 9 Rajappa M....Sharma A. (Angiology 2009)
    406. Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells. (PubMed id 19286927)1, 9 Cornell T.T....Shanley T.P. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009)
    407. Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB. (PubMed id 19074641)1, 9 Rafiee P....Shaker R. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009)
    408. Blastocystis ratti contains cysteine proteases that mediate interleukin-8 response from human intestinal epithelial cells in an NF-kappaB-dependent manner. (PubMed id 18156286)1, 9 Puthia M.K....Tan K.S. (Eukaryotic Cell 2008)
    409. Inhibition by salmeterol and cilomilast of fluticasone-enhanced IP-10 release in airway epithelial cells. (PubMed id 18259970)1, 9 Reddy P.J....Kelsen S.G. (COPD 2008)
    410. Inflammatory-activated microvascular endothelial cells regulate interleukin-8 and monocyte chemoattractant protein-1 expression of A549 cells in a paracrine fashion. (PubMed id 18266131)1, 9 Wendel M....Koch T. (Exp. Lung Res. 2008)
    411. IL-8 induces imbalances between nitric oxide and endothelin-1, and also between plasminogen activator inhibitor-1 and tissue-type plasminogen activator in cultured endothelial cells. (PubMed id 18023202)1, 9 Cheng M....Chen H. (Cytokine 2008)
    412. Angiogenesis-related growth factors and cytokines in the serum of patients with B non-Hodgkin lymphoma; relation to clinical features and response to treatment. (PubMed id 18190463)1, 9 Passam F.H....Alexandrakis M.G. (Int J Lab Hematol 2008)
    413. Expression of angiogenesis-related genes regulates different steps in the process of tumor growth and metastasis in human urothelial cell carcinoma of the urinary bladder. (PubMed id 19096229)1, 9 Chikazawa M....Shuin T. (Pathobiology 2008)
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    416. Psychosine-induced apoptosis and cytokine activation in immune peripheral cells of Krabbe patients. (PubMed id 17458901)1, 9 Formichi P....Federico A. (J. Cell. Physiol. 2007)
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    418. Interferon-gamma and bacterial lipopolysaccharide act synergistically on human neutrophils enhancing interleukin-8, interleukin-1beta, tumor necrosis factor-alpha, and interleukin-12 p70 secretion and phagocytosis via upregulation of toll-like receptor 4. (PubMed id 17304101)1, 9 Pearl-Yafe M....Shalit I. (Shock 2007)
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    420. Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils. (PubMed id 17550933)1, 9 Maneechotesuwan K....Barnes P.J. (Chest 2007)
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    422. Chemokines and incident coronary heart disease: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. (PubMed id 16825597)1, 9 Herder C....Koenig W. (Arterioscler. Thromb. Vasc. Biol. 2006)
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    427. A molecular cascade showing nitric oxide-heme oxygenase-1-vascular endothelial growth factor-interleukin-8 sequence in human endothelial cells. (PubMed id 15661856)1, 9 Pae H.O....Chung H.T. (Endocrinology 2005)
    428. GSK3 and PKB/Akt are associated with integrin-mediated regulation of PTHrP, IL-6 and IL-8 expression in FG pancreatic cancer cells. (PubMed id 15609321)1, 9 Grzesiak J.J....Bouvet M. (Int. J. Cancer 2005)
    429. Inflammatory cytokine and thrombin regulation of interleukin-8 and intercellular adhesion molecule-1 expression in first trimester human decidua. (PubMed id 15914533)1, 9 Lockwood C.J....Schatz F. (J. Clin. Endocrinol. Metab. 2005)
    430. Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes. (PubMed id 15641067)1, 9 Cecil D.L.... Liu-Bryan R. (Arthritis Rheum. 2005)
    431. Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle. (PubMed id 16029496)1, 9 Oltmanns U....Mitchell J.A. (Respir. Res. 2005)
    432. Secretion of interleukin-8 by human-derived cell lines infected with Mycobacterium bovis. (PubMed id 15203565)1, 9 MAcndez-Samperio P....GarcA-a-MartA-nez E. (Mediators Inflamm. 2004)
    433. Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK. (PubMed id 14767470)1, 9 Lee L.F....Kung H.J. (Oncogene 2004)
    434. Ligand selectivity and affinity of chemokine receptor CXCR1. Role of N-terminal domain. (PubMed id 15133028)1, 9 Rajagopalan L. and Rajarathnam K. (J. Biol. Chem. 2004)
    435. IL-8 is a key chemokine regulating neutrophil recruitment in a new mouse model of Shigella-induced colitis. (PubMed id 15356171)1, 9 Singer M. and Sansonetti P.J. (J. Immunol. 2004)
    436. Nitric oxide differentially regulates pro- and anti-angiogenic markers in DLD-1 colon carcinoma cells. (PubMed id 15063730)1, 9 Hellmuth M....MA1hl H. (FEBS Lett. 2004)
    437. Helicobacter pylori heat-shock protein 60 induces inflammatory responses through the Toll-like receptor-triggered pathway in cultured human gastric epithelial cells. (PubMed id 15583145)1, 9 Takenaka R....Oguma K. (Microbiology (Reading, Engl.) 2004)
    438. The relationship among serum cytokines, chemokine, nitric oxide, and leptin in children with type 1 diabetes mellitus. (PubMed id 15302608)1, 9 Lo H.C....Wang Y.M. (Clin. Biochem. 2004)
    439. Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation. (PubMed id 15529362)1, 9 Stabler T....Kraus V.B. (Arthritis Rheum. 2004)
    440. Serum levels of tumor necrosis factor-alpha, interleukin-6 and interleukin-8 are not increased in dyspeptic patients with Helicobacter pylori-associated gastritis. (PubMed id 15203561)1, 9 BayraktaroA9lu T....Borazan A. (Mediators Inflamm. 2004)
    441. Macrophage migration inhibitory factor up-regulates the expression of interleukin-8 messenger RNA in synovial fibroblasts of rheumatoid arthritis patients: common transcriptional regulatory mechanism between interleukin-8 and interleukin-1beta. (PubMed id 15146413)1, 9 Onodera S....Minami A. (Arthritis Rheum. 2004)
    442. Distinct cytokine production by lung and blood neutrophils from children with cystic fibrosis. (PubMed id 12547728)1, 9 Corvol H....Clement A. (Am. J. Physiol. Lung Cell Mol. Physiol. 2003)
    443. Upregulation of interleukin-8 by hypoxia in human ovaries. (PubMed id 14672330)1, 9 Yoshino O....Taketani Y. (Am. J. Reprod. Immunol. 2003)
    444. Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein. (PubMed id 12777373)1, 9 Walton K.A....Berliner J.A. (J. Biol. Chem. 2003)
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    446. Increased E-selectin, IL-8 and IL-10 gene expression in human skin after minimal trauma. (PubMed id 14714557)1, 9 Takeuchi F....Hall R.P. (Exp. Dermatol. 2003)
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    448. Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease. (PubMed id 12919697)1, 9 Bendre M.S....Suva L.J. (Bone 2003)
    449. Different affinities of glycosaminoglycan oligosaccharides for monomeric and dimeric interleukin-8: a model for chemokine regulation at inflammatory sites. (PubMed id 11814358)1, 9 Goger B....Kungl A.J. (Biochemistry 2002)
    450. Expression of interleukin 8 and not parathyroid hormone-related protein by human breast cancer cells correlates with bone metastasis in vivo. (PubMed id 12359770)1, 9 Bendre M.S....Suva L.J. (Cancer Res. 2002)
    451. Cytokine regulation of constitutive production of interleukin-8 and -6 by human pancreatic cancer cell lines and serum cytokine concentrations in patients with pancreatic cancer. (PubMed id 12239630)1, 9 Wigmore S.J....Ross J.A. (Int. J. Oncol. 2002)
    452. MCP-1, MIP-1, IL-8 and ischemic cerebral tissue enhance human bone marrow stromal cell migration in interface culture. (PubMed id 12186702)1, 9 Wang L....Chopp M. (Hematology 2002)
    453. Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1 receptor antagonist by epithelial cells. (PubMed id 11876744)1, 9 Lahav M....Chowers Y. (Clin. Exp. Immunol. 2002)
    454. Raised serum levels of interleukin-8 and interleukin-18 in relation to bone metabolism in endogenous Cushing's syndrome. (PubMed id 11888846)1, 9 Kristo C....Bollerslev J. (Eur. J. Endocrinol. 2002)
    455. Signals involved in mycobacteria-induced CXCL-8 production by human monocytes. (PubMed id 11911801)1, 9 MAcndez-Samperio P....VA!zquez A. (amp 2002)
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    462. IL-8 induces the locomotion of human IL-2-activated natural killer cells. Involvement of a guanine nucleotide binding (Go) protein. (PubMed id 8381837)1, 9 Sebok K....Maghazachi A.A. (J. Immunol. 1993)
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    466. Impaired interleukin-8 chemokine secretion by staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fibrosis. (PubMed id 19597126)1, 9 Al Alam D....Gangloff S.C. (Am. J. Respir. Cell Mol. Biol. 2010)
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    469. Pollen-induced oxidative stress influences both innate and adaptive immune responses via altering dendritic cell functions. (PubMed id 20118277)1, 9 Csillag A....Bacsi A. (J. Immunol. 2010)
    470. Enteroaggregative Escherichia coli infection induces IL-8 production via activation of mitogen-activated protein kinases and the transcription factors NF-kappaB and AP-1 in INT-407 cells. (PubMed id 19898747)1, 9 Khan K....Ghosh S. (Mol. Cell. Biochem. 2010)
    471. Oxidative stress causes IL8 promoter hyperacetylation in cystic fibrosis airway cell models. (PubMed id 18635816)1, 9 Bartling T.R. and Drumm M.L. (Am. J. Respir. Cell Mol. Biol. 2009)
    472. Low concentrations of LL-37 alter IL-8 production by keratinocytes and bronchial epithelial cells in response to proinflammatory stimuli. (PubMed id 19527294)1, 9 Filewod N.C....Hancock R.E. (FEMS Immunol. Med. Microbiol. 2009)
    473. Bacterial endotoxin activates retinal pigment epithelial cells and induces their degeneration through IL-6 and IL-8 autocrine signaling. (PubMed id 19157552)1, 9 Leung K.W....Tombran-Tink J. (Mol. Immunol. 2009)
    474. Specific NFkappaB subunit activation and kinetics of cytokine induction in adenoviral keratitis. (PubMed id 20038977)1, 9 Rajaiya J....Chodosh J. (Mol. Vis. 2009)
    475. Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy. (PubMed id 19837667)1, 9 Ma J....Xiao W. (J. Biol. Chem. 2009)
    476. Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter. (PubMed id 19734226)1, 9 John A.E....Knox A.J. (J. Immunol. 2009)
    477. Escherichia coli type 1 pili trigger late IL-8 production by neutrophil-like differentiated PLB-985 cells through a Src family kinase- and MAPK-dependent mechanism. (PubMed id 19015376)1, 9 SAcmiramoth N....Chollet-Martin S. (J. Leukoc. Biol. 2009)
    478. Extracellular heat shock protein 90 induces interleukin-8 in vascular smooth muscle cells. (PubMed id 19028451)1, 9 Chung S.W....Kim K. (Biochem. Biophys. Res. Commun. 2009)
    479. Proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation and increases interleukin-8 production in retinal pigment epithelial cells. (PubMed id 19570915)1, 9 Fernandes A.F....Shang F. (Mol. Biol. Cell 2009)
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    481. Inflammatory cytokine mRNA detection by real time PCR in chorioamniotic membranes from pregnant women with preterm premature rupture of membranes. (PubMed id 19272692)1, 9 Polettini J....Silva M.G. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2009)
    482. Cross talk initiated by endothelial cells enhances migration and inhibits anoikis of squamous cell carcinoma cells through STAT3/Akt/ERK signaling. (PubMed id 19484147)1, 9 Neiva K.G....NAPr J.E. (Neoplasia 2009)
    483. Gonadotropin-releasing hormone-regulated chemokine expression in human placentation. (PubMed id 19369450)1, 9 Cavanagh P.C....Babwah A.V. (Am. J. Physiol., Cell Physiol. 2009)
    484. 15-Deoxy-Delta(12,14)-prostaglandin J2 induces IL-8 and GM-CSF in a human airway epithelial cell line (NCI-H292). (PubMed id 19494510)1, 9 Chiba T....Chihara J. (Int. Arch. Allergy Immunol. 2009)
    485. N-methyl-D-aspartate and sigma-ligands change the production of interleukins 8 and 10 in lymphocytes through modulation of the NMDA glutamate receptor. (PubMed id 19246943)1, 9 Kvaratskhelia E....Mikeladze D.G. (Neuroimmunomodulation 2009)
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    488. Interleukin-8 is essential for normal urothelial cell survival. (PubMed id 19535567)1, 9 Tseng-Rogenski S. and Liebert M. (Am. J. Physiol. Renal Physiol. 2009)
    489. Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. (PubMed id 19732956)1, 9 Aherne C.M....Murphy E.P. (Mol. Immunol. 2009)
    490. The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastoma. (PubMed id 19668231)1, 9 Atkinson G.P....Benveniste E.N. (Oncogene 2009)
    491. Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow. (PubMed id 19229069)1, 9 Hastings N.E....Blackman B.R. (Arterioscler. Thromb. Vasc. Biol. 2009)
    492. Quantitive cytokine mRNA expression profiles in the colonic mucosa of patients with steroid naA^ve ulcerative colitis during active and quiescent disease. (PubMed id 18942752)1, 9 Matsuda R....Umemura S. (Inflamm. Bowel Dis. 2009)
    493. Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis. (PubMed id 19333684)1, 9 Sakao K....Kubo T. (J. Bone Miner. Metab. 2009)
    494. Adiponectin-stimulated CXCL8 release in primary human hepatocytes is regulated by ERK1/ERK2, p38 MAPK, NF-kappaB, and STAT3 signaling pathways. (PubMed id 19608729)1, 9 Wanninger J....Buechler C. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009)
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    496. Regulation of chemokine gene expression by hypoxia via cooperative activation of NF-kappaB and histone deacetylase. (PubMed id 19446037)1, 9 Safronova O....Morita I. (amp 2009)
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    498. Serum interleukin-8 levels are elevated in patients with ovarian endometrioma. (PubMed id 18635170)1, 9 Ohata Y....Terakawa N. (Fertil. Steril. 2008)
    499. Differential signaling mechanisms of HNP-induced IL-8 production in human lung epithelial cells and monocytes. (PubMed id 17786963)1, 9 Syeda F....Zhang H. (J. Cell. Physiol. 2008)
    500. The effects of interleukin-8 on airway smooth muscle contraction in cystic fibrosis. (PubMed id 19046427)1, 9 Govindaraju V....Martin J.G. (Respir. Res. 2008)
    501. Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. (PubMed id 18307536)1, 9 Li M....Yao Q. (Cancer Sci. 2008)
    502. Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts. (PubMed id 18501560)1, 9 Tong K.M....Tang C.H. (Cell. Signal. 2008)
    503. PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells. (PubMed id 18854173)1, 9 Tanaka Y....Kawabata A. (Biochem. Biophys. Res. Commun. 2008)
    504. Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms. (PubMed id 18395088)1, 9 Subramaniam D....Anant S. (Gastroenterology 2008)
    505. Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells. (PubMed id 18678662)1, 9 Snoeks L....Savkovic S.D. (Infect. Immun. 2008)
    506. Insulin induces monocytic CXCL8 secretion by the mitogenic signalling pathway. (PubMed id 18789871)1, 9 Wurm S....Buechler C. (Cytokine 2008)
    507. Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cells. (PubMed id 18252714)1, 9 Bhattacharyya S....Tobacman J.K. (J. Biol. Chem. 2008)
    508. The local cytokine and chemokine milieu within malignant effusions. (PubMed id 18515987)1, 9 Atanackovic D....Bokemeyer C. (Tumour Biol. 2008)
    509. Circulating and airway neutrophils in cystic fibrosis display different TLR expression and responsiveness to interleukin-10. (PubMed id 18054497)1, 9 Petit-Bertron A.F....Adib-Conquy M. (Cytokine 2008)
    510. Signal transduction for formation/release of interleukin-8 caused by a PAR2-activating peptide in human lung epithelial cells. (PubMed id 17854923)1, 9 Moriyuki K....Kawabata A. (Regul. Pept. 2008)
    511. Cryptococcus neoformans induces IL-8 secretion and CXCL1 expression by human bronchial epithelial cells. (PubMed id 18211687)1, 9 Guillot L....Qureshi S.T. (Respir. Res. 2008)
    512. Osteopontin and interleukin-8 expression is independently associated with prostate cancer recurrence. (PubMed id 18593988)1, 9 Caruso D.J....Lokeshwar B.L. (Clin. Cancer Res. 2008)
    513. Double-stranded RNA-activated protein kinase mediates induction of interleukin-8 expression by deoxynivalenol, Shiga toxin 1, and ricin in monocytes. (PubMed id 18599499)1, 9 Gray J.S....Pestka J.J. (Toxicol. Sci. 2008)
    514. Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4. (PubMed id 18031543)1, 9 Voelcker V....Simon J. (Exp. Dermatol. 2008)
    515. Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells. (PubMed id 18380907)1, 9 Issa R....Mitchell J.A. (Respir. Res. 2008)
    516. Induction of IL-8 by Mycoplasma pneumoniae membrane in BEAS-2B cells. (PubMed id 18487355)1, 9 Chmura K....Chan E.D. (Am. J. Physiol. Lung Cell Mol. Physiol. 2008)
    517. IL-8 and p53 are inversely regulated through JNK, p38 and NF-kappaB p65 in HepG2 cells during an inflammatory response. (PubMed id 18607537)1, 9 Rasmussen M.K....Gesser B. (Inflamm. Res. 2008)
    518. Oxidative stress induces extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase in cystic fibrosis lung epithelial cells: Potential mechanism for excessive IL-8 expression. (PubMed id 17936667)1, 9 Boncoeur E....Tabary O. (amp 2008)
    519. Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling. (PubMed id 17420005)1, 9 Muselet-Charlier C....Tabary O. (Biochem. Biophys. Res. Commun. 2007)
    520. Bronchoalveolar cellularity and interleukin-8 levels in measles bronchiolitis obliterans. (PubMed id 17494793)1, 9 Koh Y.Y....Kim C.K. (Chest 2007)
    521. Increased serum levels of CXCL8 chemokine in acute toxoplasmic retinochoroiditis. (PubMed id 17488320)1, 9 GonAsalves R.M....Teixeira A.L. (Acta Ophthalmol Scand 2007)
    522. Regulation of interleukin-8 via an airway epithelial signaling cascade. (PubMed id 17220369)1, 9 Nakanaga T....Shao M.X. (Am. J. Physiol. Lung Cell Mol. Physiol. 2007)
    523. Anti-IL-8 autoantibody:IL-8 immune complexes suppress spontaneous apoptosis of neutrophils. (PubMed id 17513455)1, 9 Fudala R....Kurdowska A.K. (Am. J. Physiol. Lung Cell Mol. Physiol. 2007)
    524. Uterine cervical inflammatory cytokines, interleukin-6 and -8, as predictors of miscarriage in recurrent cases. (PubMed id 17845205)1, 9 Hattori Y....Sugiura-Ogasawara M. (Am. J. Reprod. Immunol. 2007)
    525. Helicobacter pylori environmental interactions: effect of acidic conditions on H. pylori-induced gastric mucosal interleukin-8 production. (PubMed id 17517062)1, 9 Choi I.J....Yamaoka Y. (Cell. Microbiol. 2007)
    526. Helicobacter pylori heat-shock protein 60 induces interleukin-8 via a Toll-like receptor (TLR)2 and mitogen-activated protein (MAP) kinase pathway in human monocytes. (PubMed id 17244794)1, 9 Zhao Y....Oguma K. (J. Med. Microbiol. 2007)
    527. Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cells. (PubMed id 17540779)1, 9 Bhattacharyya S....Tobacman J.K. (Am. J. Physiol. Gastrointest. Liver Physiol. 2007)
    528. Stored packed red blood cell transfusion up-regulates inflammatory gene expression in circulating leukocytes. (PubMed id 17592301)1, 9 Escobar G.A....Banerjee A. (Ann. Surg. 2007)
    529. L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion. (PubMed id 17022986)1, 9 Abe Y....Ballantyne C.M. (Atherosclerosis 2007)
    530. Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways. (PubMed id 17466952)1, 9 Verhaeghe C....Bours V. (Biochem. Pharmacol. 2007)
    531. Pleural fluid IL-8 as an inflammatory mediator for discriminating transudates and exudates. (PubMed id 20306660)1, 9 Zaki S.M. and Ashour L. (Egypt J Immunol 2007)
    532. Chemokine signaling specificity: essential role for the N-terminal domain of chemokine receptors. (PubMed id 17630697)1, 9 Prado G.N....Navarro J. (Biochemistry 2007)
    533. Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB. (PubMed id 16928771)1, 9 Chiu T.T.... Rozengurt E. (Am. J. Physiol. 2007)
    534. Calcium-calmodulin mediates house dust mite-induced ERK activation and IL-8 production in human respiratory epithelial cells. (PubMed id 17268170)1, 9 Sohn M.H....Kim K.E. ( international review of thoracic diseases 2007)
    535. Regulation of interleukin-8 expression in melanoma-stimulated neutrophil inflammatory response. (PubMed id 17141217)1, 9 Peng H.H....Dong C. (Exp. Cell Res. 2007)
    536. Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets. (PubMed id 17908789)1, 9 Winzen R....Holtmann H. (Mol. Cell. Biol. 2007)
    537. Azithromycin suppresses activation of nuclear factor-kappa B and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants. (PubMed id 17667842)1, 9 Aghai Z.H....Rahman I. (Pediatr. Res. 2007)
    538. HtpG, the Porphyromonas gingivalis HSP-90 homologue, induces the chemokine CXCL8 in human monocytic and microvascular vein endothelial cells. (PubMed id 17346315)1, 9 Shelburne C.E....Lopatin D.E. (Cell. Microbiol. 2007)
    539. Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer. (PubMed id 17854143)1, 9 Rubie C....Schilling M.K. (World J. Gastroenterol. 2007)
    540. Plasma levels of interleukin-6 and interleukin-8 in Chinese patients with non-alcoholic fatty liver disease. (PubMed id 18251157)1, 9 Chu C.J....Lee S.D. (Hepatogastroenterology 2007)
    541. IL-8 and IDO expression by human gingival fibroblasts via TLRs. (PubMed id 17202379)1, 9 Mahanonda R....Pichyangkul S. (J. Immunol. 2007)
    542. Induction of urokinase-type plasminogen activator, interleukin-8 and early growth response-1 by STI571 through activating mitogen activated protein kinase in human small cell lung cancer cells. (PubMed id 17581316)1, 9 Yoshida C....Tanimoto M. (amp 2007)
    543. Pneumocystis-mediated IL-8 release by macrophages requires coexpression of mannose receptors and TLR2. (PubMed id 17020928)1, 9 Tachado S.D....Koziel H. (J. Leukoc. Biol. 2007)
    544. Histamine H1 receptor-stimulated interleukin 8 and granulocyte macrophage colony-stimulating factor production by bronchial epithelial cells requires extracellular signal-regulated kinase signaling via protein kinase C. (PubMed id 16491014)1, 9 Matsubara M....Hasegawa K. (Int. Arch. Allergy Immunol. 2006)
    545. Low-density lipoprotein modified by macrophage-derived lysosomal hydrolases induces expression and secretion of IL-8 via p38 MAPK and NF-kappaB by human monocyte-derived macrophages. (PubMed id 16973972)1, 9 Hakala J.K....PentikAoinen M.O. (Arterioscler. Thromb. Vasc. Biol. 2006)
    546. Characterization of TGF-beta-regulated interleukin-8 expression in human prostate cancer cells. (PubMed id 16541418)1, 9 Lu S. and Dong Z. (Prostate 2006)
    547. Insulin-like growth factor-I augments interleukin-8 promoter activity through induction of activator protein-1 complex formation. (PubMed id 16846747)1, 9 Kooijman R....Van den Keybus C. (amp 2006)
    548. Urine cytokines profile in renal transplant patients with asymptomatic bacteriuria. (PubMed id 16794530)1, 9 Ciszek M....Mucha K. (Transplantation 2006)
    549. Interleukin-8 secretion by fibroblasts induced by low density lipoproteins is p38 MAPK-dependent and leads to cell spreading and wound closure. (PubMed id 16251188)1, 9 Dobreva I....Widmann C. (J. Biol. Chem. 2006)
    550. Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cdelta, Lyn kinase, and matrix metalloproteinases. (PubMed id 16687414)1, 9 Zhao Y....Natarajan V. (J. Biol. Chem. 2006)
    551. Cytoskeletal architecture differentially controls post-transcriptional processing of IL-6 and IL-8 mRNA in airway epithelial-like cells. (PubMed id 16499908)1, 9 van den Berg A....Lutter R. (Exp. Cell Res. 2006)
    552. Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells. (PubMed id 16197369)1, 9 Saatian B....Natarajan V. (Biochem. J. 2006)
    553. Neutrophil elastase induces IL-8 gene transcription and protein release through p38/NF-{kappa}B activation via EGFR transactivation in a lung epithelial cell line. (PubMed id 16632517)1, 9 Kuwahara I....Kim K.C. (Am. J. Physiol. Lung Cell Mol. Physiol. 2006)
    554. Mechanical stretch stimulates interleukin-8 production in endometrial stromal cells: possible implications in endometrium-related events. (PubMed id 15585560)1, 9 Harada M....Taketani Y. (J. Clin. Endocrinol. Metab. 2005)
    555. Polyamine depletion inhibits NF-kappaB binding to DNA and interleukin-8 production in human chondrocytes stimulated by tumor necrosis factor-alpha. (PubMed id 15828019)1, 9 Facchini A....Flamigni F. (J. Cell. Physiol. 2005)
    556. Human neutrophils promote angiogenesis by a paracrine feedforward mechanism involving endothelial interleukin-8. (PubMed id 15498828)1, 9 Schruefer R....Walzog B. (Am. J. Physiol. Heart Circ. Physiol. 2005)
    557. Autocrine and paracrine regulation of interleukin-8 expression in lung cancer cells. (PubMed id 15746434)1, 9 Yao P.L....Yang P.C. (Am. J. Respir. Cell Mol. Biol. 2005)
    558. Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro. (PubMed id 15564333)1, 9 Lappas M....Rice G.E. (Endocrinology 2005)
    559. Induction of a CXCL8 binding site on endothelial syndecan-3 in rheumatoid synovium. (PubMed id 16052590)1, 9 Patterson A.M....Middleton J. (Arthritis Rheum. 2005)
    560. Interleukin-8 in whole blood and clinical status in cystic fibrosis. (PubMed id 15579374)1, 9 Schmitt-GrohAc S....Zielen S. (Cytokine 2005)
    561. Correlation of augmented IL-8 production to premature chronic lung disease: implication of posttranscriptional regulation. (PubMed id 16085794)1, 9 Huang H.C....Yang K.D. (Pediatr. Res. 2005)
    562. MEK1-dependent delayed expression of Fos-related antigen-1 counteracts c-Fos and p65 NF-kappaB-mediated interleukin-8 transcription in response to cytokines or growth factors. (PubMed id 15615716)1, 9 Hoffmann E....Kracht M. (J. Biol. Chem. 2005)
    563. Interleukin 8 dimerization as a mechanism for regulation of neutrophil adherence-dependent oxidant production. (PubMed id 15803062)1, 9 Williams M.A....Solomkin J.S. (Shock 2005)
    564. Interleukin-8 induces nuclear transcription factor-kappaB through a TRAF6-dependent pathway. (PubMed id 15591054)1, 9 Manna S.K. and Ramesh G.T. (J. Biol. Chem. 2005)
    565. In vivo relationship between collagenase-2 and interleukin-8 but not tumour necrosis factor-alpha in chronic rhinosinusitis with nasal polyposis. (PubMed id 16134994)1, 9 Kostamo K....Toskala E. (Allergy 2005)
    566. Neutrophil elastase induces IL-8 synthesis by lung epithelial cells via the mitogen-activated protein kinase pathway. (PubMed id 14730209)1, 9 Chen H.C....Kuo H.P. (J. Biomed. Sci. 2004)
    567. Cyclic mechanical stretch augments both interleukin-8 and monocyte chemotactic protein-3 production in the cultured human uterine cervical fibroblast cells. (PubMed id 15194816)1, 9 Takemura M....Fujii S. (Mol. Hum. Reprod. 2004)
    568. Interleukin (IL)-1 beta in tracheal aspirates from premature infants induces airway epithelial cell IL-8 expression via an NF-kappa B dependent pathway. (PubMed id 15496610)1, 9 Shimotake T.K....Hershenson M.B. (Pediatr. Res. 2004)
    569. Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. (PubMed id 15280372)1, 9 Cummings R....Natarajan V. (J. Biol. Chem. 2004)
    570. Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris. (PubMed id 15102084)1, 9 Iwakiri K....Kawanami O. (J. Invest. Dermatol. 2004)
    571. Human neutrophils synthesize IL-8 in an IgE-mediated activation. (PubMed id 15178703)1, 9 MonteseirA-n J....Sobrino F. (J. Leukoc. Biol. 2004)
    572. CXCR1-binding chemokines in inflammatory bowel diseases: down-regulated IL-8/CXCL8 production by leukocytes in Crohn's disease and selective GCP-2/CXCL6 expression in inflamed intestinal tissue. (PubMed id 15214047)1, 9 Gijsbers K....Van Damme J. (Eur. J. Immunol. 2004)
    573. Interleukin-1beta stimulates IL-8 expression through MAP kinase and ROS signaling in human gastric carcinoma cells. (PubMed id 15208668)1, 9 Hwang Y.S....Jung Y.D. (Oncogene 2004)
    574. Production of interleukin-8 by human neutrophils stimulated with Trichomonas vaginalis. (PubMed id 14977935)1, 9 Ryu J.S....Min D.Y. (Infect. Immun. 2004)
    575. Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury. (PubMed id 14729508)1, 9 Krupa A....Kurdowska A.K. (Am. J. Physiol. Lung Cell Mol. Physiol. 2004)
    576. Serum interleukin-8 is elevated in men with prostate cancer and bone metastases. (PubMed id 15453805)1, 9 Lehrer S....Stock R.G. (amp 2004)
    577. The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric cancer cells. (PubMed id 15300588)1, 9 Tanida S....Itoh M. (Gastroenterology 2004)
    578. Bacterial products increase expression of the human cathelicidin hCAP-18/LL-37 in cultured human sinus epithelial cells. (PubMed id 15364108)1, 9 Nell M.J....Grote J.J. (FEMS Immunol. Med. Microbiol. 2004)
    579. Haplotype mapping of the bronchiolitis susceptibility locus near IL8. (PubMed id 14605870)4, 9 Hull J....Kwiatkowski D.P. (Hum. Genet. 2004)
    580. Ergothioneine inhibits oxidative stress- and TNF-alpha-induced NF-kappa B activation and interleukin-8 release in alveolar epithelial cells. (PubMed id 12646250)1, 9 Rahman I....Aruoma O.I. (Biochem. Biophys. Res. Commun. 2003)
    581. Up-regulation of interleukin-8 by novel small cytoplasmic molecules of nontypeable Haemophilus influenzae via p38 and extracellular signal-regulated kinase pathways. (PubMed id 14500470)1, 9 Wang B....Li J.D. (Infect. Immun. 2003)
    582. Cockroach proteases increase IL-8 expression in human bronchial epithelial cells via activation of protease-activated receptor (PAR)-2 and extracellular-signal-regulated kinase. (PubMed id 14657869)1, 9 Page K....Hershenson M.B. (J. Allergy Clin. Immunol. 2003)
    583. mRNA expression and release of interleukin-8 induced by serum amyloid A in neutrophils and monocytes. (PubMed id 12857601)1, 9 Ribeiro F.P....Campa A. (Mediators Inflamm. 2003)
    584. Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-kappaB. (PubMed id 12960242)1, 9 Iho S....Takahashi T. (J. Leukoc. Biol. 2003)
    585. Expression of matrix metalloproteinases, sICAM-1 and IL-8 in CSF from children with meningitis. (PubMed id 12480084)1, 9 Shapiro S....Lerner A. (J. Neurol. Sci. 2003)
    586. Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8. (PubMed id 12855659)1, 9 Karashima T....Dinney C.P. (Clin. Cancer Res. 2003)
    587. IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. (PubMed id 12626597)1, 9 Li A....Singh R.K. (J. Immunol. 2003)
    588. Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma. (PubMed id 12668613)4, 9 Shin H.D....Lee H.S. (Hum. Mol. Genet. 2003)
    589. Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2. (PubMed id 12628493)1, 9 Catusse J....Paquet J.L. (Biochem. Pharmacol. 2003)
    590. Transcriptional inhibition of interleukin-8 expression in tumor necrosis factor-tolerant cells: evidence for involvement of C/EBP beta. (PubMed id 12707271)1, 9 Weber M....Brand K. (J. Biol. Chem. 2003)
    591. Morphological analyses of interleukin-8 effects on rat ovarian follicles at ovulation and luteinization in vivo. (PubMed id 12543081)1, 9 Goto J....Kanayama N. (Cytokine 2002)
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    624. Potentiation of inflammatory CXCL8 signalling sustains cell survival in PTEN-deficient prostate carcinoma. (PubMed id 22939387)1 Maxwell P.J....Waugh D.J. (Eur. Urol. 2013)
    625. Fas/CD95-induced chemokines can serve as &quot;find-me&quot; signals for apoptotic cells. (PubMed id 23434371)1 Cullen S.P....Martin S.J. (Mol. Cell 2013)
    626. Interleukin 8 promoter polymorphism predicts the initial response to bevacizumab treatment for exudative age-related macular degeneration. (PubMed id 23584701)1 HautamAoki A....Immonen I. (Retina (Philadelphia, Pa.) 2013)
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    628. Differential regulation of CC chemokine ligand 2 and CXCL8 by antifungal agent nystatin in macrophages. (PubMed id 23831464)1 Kim D.H....Kim K. (Biochem. Biophys. Res. Commun. 2013)
    629. GI+a88a88 drives invasion of oral squamous cell carcinoma through up-regulation of proinflammatory cytokines. (PubMed id 23762476)1 Jian S.L....Juang J.L. (PLoS ONE 2013)
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    634. Histone deacetylases enzyme, copper, and IL-8 levels in patients with Alzheimer's disease. (PubMed id 23242124)1 Alsadany M.A....Mahfouz R.G. (Am J Alzheimers Dis Other Demen 2013)
    635. Differentiation of CC vs CXC chemokine dimers with GAG octasaccharide binding partners: an ion mobility mass spectrometry approach. (PubMed id 23418647)1 Seo Y....Leary J.A. (J. Am. Chem. Soc. 2013)
    636. IL-8 -251T/A and IL-12B 1188A/C polymorphisms are associated with gout in a Chinese male population. (PubMed id 23441821)1 Liu S....Li C. (Scand. J. Rheumatol. 2013)
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    639. PORF5 plasmid protein of Chlamydia trachomatis induces MAPK-mediated pro-inflammatory cytokines via TLR2 activation in THP-1 cells. (PubMed id 23546865)1 Zhou H....Zhong G. (Sci China Life Sci 2013)
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    641. Association between interleukin-8 gene -251 T/A polymorphism and the risk of peptic ulcer disease: a meta-analysis. (PubMed id 23000201)1 Yin Y.W....Shi L.B. (Hum. Immunol. 2013)
    642. Increased prevalence of autoimmune phenomena in myelofibrosis: relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns. (PubMed id 24080022)1 Barcellini W....Cortelezzi A. (Leuk. Res. 2013)
    643. SUMOylation of PPARI^ by rosiglitazone prevents LPS-induced NCoR degradation mediating down regulation of chemokines expression in renal proximal tubular cells. (PubMed id 24260304)1 Lu Y....Wang W. (PLoS ONE 2013)
    644. Toll-like receptor 4 signaling pathway mediates proinflammatory immune response to cobalt-alloy particles. (PubMed id 23680697)1 Potnis P.A....Wood S.C. (Cell. Immunol. 2013)
    645. Int6/eIF3e silenced HIF2I+ stabilization enhances migration and tube formation of HUVECs via IL-6 and IL-8 signaling. (PubMed id 23478175)1 Endler A....Shibasaki F. (Cytokine 2013)
    646. Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia. (PubMed id 22869038)1 Fillman S.G....Weickert C.S. (Mol. Psychiatry 2013)
    647. CD4+ T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infection. (PubMed id 23165450)1 Brand H.K....Hermans P.W. (Pediatr. Res. 2013)
    648. Clinical significance of CXCL-8/CXCR-2 network in esophageal squamous cell carcinoma. (PubMed id 23972657)1 Ogura M....Kitagawa Y. (Surgery 2013)
    649. Association of IL-8 gene polymorphisms with non small cell lung cancer in Tunisia: A case control study. (PubMed id 23831257)1 Rafrafi A....Sassi F.H. (Hum. Immunol. 2013)
    650. Proteasome inhibition by bortezomib increases IL-8 expression in androgen-independent prostate cancer cells: the role of IKKI+. (PubMed id 23894194)1 Manna S....Vancurova I. (J. Immunol. 2013)
    651. Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines. (PubMed id 22354777)1 Suzuki T....Ochi T. (J Appl Toxicol 2013)
    652. Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes. (PubMed id 23770363)1 Jain S.K. and Micinski D. (Biochem. Biophys. Res. Commun. 2013)
    653. Interleukin-8 prevents oxidative stress-induced human endothelial cell senescence via telomerase activation. (PubMed id 23597430)1 Shen X.H....Fu G.S. (Int. Immunopharmacol. 2013)
    654. Evaluation of TGF I^1, IL-8 and nitric oxide in the serum of diffuse axonal injury patients and its association with clinical status and outcome. (PubMed id 23546898)1 Sohrevardi S.M....Savari O. (Turk Neurosurg 2013)
    655. TRAIL-induced expression of uPA and IL-8 strongly enhanced by overexpression of TRAF2 and Bcl-xL in pancreatic ductal adenocarcinoma cells. (PubMed id 23392805)1 Zhou D.H....Trauzold A. (amp 2013)
    656. Dysfunctional activation of neurotensin/IL-8 pathway in hepatocellular carcinoma is associated with increased inflammatory response in microenvironment, more epithelial mesenchymal transition in cancer and worse prognosis in patients. (PubMed id 23418512)1 Yu J....Hao X. (PLoS ONE 2013)
    657. S. aureus haemolysin A-induced IL-8 and IL-6 release from human airway epithelial cells is mediated by activation of p38- and Erk-MAP kinases and additional, cell type-specific signalling mechanisms. (PubMed id 23347173)1 RAoth S....Hildebrandt J.P. (Cell. Microbiol. 2013)
    658. Hepatitis B virus (HBV) induces the expression of interleukin-8 that in turn reduces HBV sensitivity to interferon-alpha. (PubMed id 23890815)1 Pollicino T....Raimondo G. (Virology 2013)
    659. Oral supplementation with Lactobacillus delbrueckii subsp. bulgaricus 8481 enhances systemic immunity in elderly subjects. (PubMed id 22645023)1 Moro-GarcA-a M.A....LA^pez-Larrea C. (Age (Dordr) 2013)
    660. Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8. (PubMed id 23633491)1 Hartman Z.C....Brown P.H. (Cancer Res. 2013)
    661. A chemokine self-presentation mechanism involving formation of endothelial surface microstructures. (PubMed id 23325889)1 Whittall C....Middleton J. (J. Immunol. 2013)
    662. YKL-40 induces IL-8 expression from bronchial epithelium via MAPK (JNK and ERK) and NF-I_B pathways, causing bronchial smooth muscle proliferation and migration. (PubMed id 23197259)1 Tang H....Li B. (J. Immunol. 2013)
    663. NOD2 triggers PGE2 synthesis leading to IL-8 activation in Staphylococcus aureus-infected human conjunctival epithelial cells. (PubMed id 24099766)1 Venza I....Venza M. (Biochem. Biophys. Res. Commun. 2013)
    664. IL-8 predicts pediatric oncology patients with febrile neutropenia at low risk for bacteremia. (PubMed id 23425997)1 Cost C.R....Leavey P. (J. Pediatr. Hematol. Oncol. 2013)
    665. Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche. (PubMed id 24121485)1 Infanger D.W....Fischbach C. (Cancer Res. 2013)
    666. Urine IL-18, NGAL, IL-8 and serum IL-8 are biomarkers of acute kidney injury following liver transplantation. (PubMed id 23327592)1 Sirota J.C....Edelstein C.L. (BMC Nephrol 2013)
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    669. Hepatocyte growth factor-mediated gastrin-releasing peptide induces IL-8 expression through Ets-1 in gastric cancer cells. (PubMed id 23924923)1 Lee K.H....Kim J.R. (Oncol. Res. 2013)
    670. Cowpox virus but not Vaccinia virus induces secretion of CXCL1, IL-8 and IL-6 and chemotaxis of monocytes in vitro. (PubMed id 23207068)1 Bourquain D. and Nitsche A. (Virus Res. 2013)
    671. Modulation of IL-8 boosted by Mycoplasma pneumoniae lysate in human airway epithelial cells. (PubMed id 23779254)1 Lee K.E....Sohn M.H. (J. Clin. Immunol. 2013)
    672. Role of interleukin-8 and oxidative stress in patients with hepatocellular carcinoma. (PubMed id 24273918)1 Yahya R.S....Enany S.A. (Clin. Lab. 2013)
    673. Elevated serum high-sensitivity C-reactive protein levels in fibromyalgia syndrome patients correlate with body mass index, interleukin-6, interleukin-8, erythrocyte sedimentation rate. (PubMed id 23124693)1 Xiao Y....Russell I.J. (Rheumatol. Int. 2013)
    674. The depletion of interleukin-8 causes cell cycle arrest and increases the efficacy of docetaxel in breast cancer cells. (PubMed id 23321310)1 Shao N....Wang S.M. (Biochem. Biophys. Res. Commun. 2013)
    675. Epigenetic regulation of IL-8 and I^-defensin genes in human keratinocytes in response to Malassezia furfur. (PubMed id 23519334)1 Angrisano T....Donnarumma G. (J. Invest. Dermatol. 2013)
    676. Stimulation of CD107 affects LPS-induced cytokine secretion and cellular adhesion through the ERK signaling pathway in the human macrophage-like cell line, THP-1. (PubMed id 23603048)1 Min B.K....Lee W.H. (Cell. Immunol. 2013)
    677. Gankyrin activates IL-8 to promote hepatic metastasis of colorectal cancer. (PubMed id 23576566)1 Bai Z....Zhou T. (Cancer Res. 2013)
    678. Different circulating levels of monocyte chemoattractant protein-1 and interleukin-8 during the menopausal transition. (PubMed id 23490412)1 Tani A....Irahara M. (Cytokine 2013)
    679. Interferon-I^ and tumor necrosis factor-I+ sustain secretion of specific CXC chemokines in human thyrocytes: a first step toward a differentiation between autoimmune and tumor-related inflammation? (PubMed id 23118425)1 Rotondi M....Chiovato L. (J. Clin. Endocrinol. Metab. 2013)
    680. High gene expression of CXCL8 is associated with the presence of extraintestinal manifestations and long-term disease in patients with ulcerative colitis. (PubMed id 22223513)1 Fonseca-Camarillo G. and Yamamoto-Furusho J.K. (Inflamm. Bowel Dis. 2013)
    681. IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism. (PubMed id 23221335)1 Roux J....Pittet J.F. (FASEB J. 2013)
    682. A one year longitudinal study of cytokine genes and depression in breast cancer. (PubMed id 23276701)1 Kim J.M....Yoon J.S. (J Affect Disord 2013)
    683. Neutrophil chemotaxis caused by chronic obstructive pulmonary disease alveolar macrophages: the role of CXCL8 and the receptors CXCR1/CXCR2. (PubMed id 23912333)1 Kaur M. and Singh D. (J. Pharmacol. Exp. Ther. 2013)
    684. Serum cytokines correlated with the disease severity of generalized pustular psoriasis. (PubMed id 23334651)1 Yamamoto M....Yamanishi K. (Dis. Markers 2013)
    685. Matrix metalloproteinase 8 (collagenase 2) induces the expression of interleukins 6 and 8 in breast cancer cells. (PubMed id 23632023)1 Thirkettle S....Edwards D.R. (J. Biol. Chem. 2013)
    686. The significance of non correlation between interleukin-8 serum levels with bone marrow microvascular density in patients with myeloma multiple. (PubMed id 23456515)1 Pappa C.A....Stathopoulos E.N. (Pathol. Oncol. Res. 2013)
    687. Activation of NF-I_B signalling by fusicoccin-induced dimerization. (PubMed id 23269842)1 Skwarczynska M....Ottmann C. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    688. Carbocysteine regulates innate immune responses and senescence processes in cigarette smoke stimulated bronchial epithelial cells. (PubMed id 24076166)1 Pace E....Gjomarkaj M. (Toxicol. Lett. 2013)
    689. Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation. (PubMed id 24032673)1 Joseph P.R....Rajarathnam K. (Biochem. J. 2013)
    690. Prognostic values of VEGF and IL-8 in malignant pleural effusion in patients with lung cancer. (PubMed id 23688054)1 Cheng D....Li Y. (Biomarkers 2013)
    691. Overexpression of USP14 protease reduces I-I_B protein levels and increases cytokine release in lung epithelial cells. (PubMed id 23615914)1 Mialki R.K....Zhao Y. (J. Biol. Chem. 2013)
    692. The activation of HMGB1 as a progression factor on inflammation response in normal human bronchial epithelial cells through RAGE/JNK/NF-I_B pathway. (PubMed id 23712703)1 Wu X....Shang C. (Mol. Cell. Biochem. 2013)
    693. IL1beta, IL6 and IL8 gene polymorphisms involvement in recurrent corneal erosion in patients with hereditary stromal corneal dystrophies. (PubMed id 23821953)1 Kucherenko A.M....Livshits L.A. (Tsitol. Genet. 2013)
    694. Targeted blockade of interleukin-8 abrogates its promotion of cervical cancer growth and metastasis. (PubMed id 23247723)1 Wu S....Xie J. (Mol. Cell. Biochem. 2013)
    695. Autocrine IL-8 and VEGF mediate epithelial-mesenchymal transition and invasiveness via p38/JNK-ATF-2 signalling in A549 lung cancer cells. (PubMed id 23714383)1 Desai S....Pandey B.N. (Cell. Signal. 2013)
    696. Effect of orthodontic force on inflammatory periodontal tissue remodeling and expression of IL-6 and IL-8 in rats. (PubMed id 23870461)1 Yang J.H....Han X.P. (Asian Pac J Trop Med 2013)
    697. Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra. (PubMed id 23577098)1 de-Torres J.P....Zulueta J.J. (PLoS ONE 2013)
    698. The prognostic role of interleukin-8 (IL-8) and matrix metalloproteinases -2 and -9 in lymph node-negative untreated breast cancer patients. (PubMed id 24344010)1 Milovanovic J....Abu Rabi Z. (J BUON 2013)
    699. Urinary concentration of cytokines in children with acute pyelonephritis. (PubMed id 23389820)1 Renata Y....Klein-Kremer A. (Eur. J. Pediatr. 2013)
    700. 15-Deoxy-I9(12,14)-prostaglandin J(2) modulates lipopolysaccharide-induced chemokine expression by blocking nuclear factor-I_B activation via peroxisome proliferator activated receptor-I^-independent mechanism in renal tubular epithelial cells. (PubMed id 23887394)1 Lu Y....Chen N. (Nephron Exp. Nephrol. 2013)
    701. Gastrokine 1 regulates NF-I_B signaling pathway and cytokine expression in gastric cancers. (PubMed id 23444260)1 Yoon J.H....Park W.S. (J. Cell. Biochem. 2013)
    702. Regulation of Wnt4 in chronic obstructive pulmonary disease. (PubMed id 23463699)1 Durham A.L....Adcock I.M. (FASEB J. 2013)
    703. NF-I_B-dependent IL-8 induction by prostaglandin E(2) receptors EP(1) and EP(4). (PubMed id 22924768)1 NeuschAofer-Rube F....PA1schel G.P. (Br. J. Pharmacol. 2013)
    704. Prognostic value of interleukin-6 and interleukin-8 in laryngeal squamous cell cancer. (PubMed id 23269580)1 Hao W....Zhou H. (Med. Oncol. 2013)
    705. Nap1 regulates proper CENP-B binding to nucleosomes. (PubMed id 23325853)1 Tachiwana H....Kurumizaka H. (Nucleic Acids Res. 2013)
    706. Innate immune dysfunction is associated with enhanced disease severity in infants with severe respiratory syncytial virus bronchiolitis. (PubMed id 23204162)1 Mella C....Mejias A. (J. Infect. Dis. 2013)
    707. Lentivirus-mediated ADAM17 RNA interference inhibited interleukin-8 expression via EGFR signaling in lung epithelial cells. (PubMed id 21932060)1 Li Y....Xia Y. (Inflammation 2012)
    708. Imatinib treatment inhibit IL-6, IL-8, NF-KB and AP-1 production and modulate intracellular calcium in CML patients. (PubMed id 21938724)1 Ciarcia R....Giordano A. (J. Cell. Physiol. 2012)
    709. Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer. (PubMed id 21544811)1 Sunaga N....Mori M. (Int. J. Cancer 2012)
    710. Bronchial hyperresponsiveness in seasonal allergic rhinitis patients is associated with increased IL-18 during natural pollen exposure. (PubMed id 22819246)1 Kurt E....Alatas O. (Cytokine 2012)
    711. Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis. (PubMed id 22617157)1 Lee Y.S....Hong Y.K. (Br. J. Cancer 2012)
    712. HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes. (PubMed id 22301094)1 DA-az-DelfA-n J....Villarroya F. (Antivir. Ther. (Lond.) 2012)
    713. AP-1 and NF-I_B transcriptionally regulate interleukin-8 in EA.Hy926 cells under shear stress. (PubMed id 21895606)1 Zhang Y....Liu Y.F. (Cell Biol. Int. 2012)
    714. [High-mobility group box protein 1 in synergy with interleukin-1I^ promotes interleukin-8 expression in human airway epithelial cells in vitro]. (PubMed id 23268406)1 Zhang D....Cai S. (Nan Fang Yi Ke Da Xue Xue Bao 2012)
    715. Increased expression of MMP-9 and IL-8 are correlated with poor prognosis of Bladder Cancer. (PubMed id 22695075)1 Reis S.T....Dall'Oglio M.F. (BMC Urol 2012)
    716. Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production. (PubMed id 22303451)1 Fitzgerald J.P....Block K. (PLoS ONE 2012)
    717. IL8 and serum soluble TRAIL levels following anti-VEGF monoclonal antibody treatment in patients with metastatic colon cancer. (PubMed id 22783581)1 Kargi A....Gorczynski R.M. (Clin. Lab. 2012)
    718. Cord blood levels of IL-6, IL-8 and IL-10 may be early predictors of bronchopulmonary dysplasia in preterm newborns small for gestational age. (PubMed id 22710869)1 Rocha G....GuimarALes H. (Dis. Markers 2012)
    719. Interleukin-8 in the pathogenesis of primary central nervous system lymphoma in association with HIV infection. (PubMed id 22664113)1 Sasakawa A....Maeda Y. (Hematology 2012)
    720. siRNA high-throughput kinase library screen identifies protein kinase, DNA-activated catalytic polypeptide to play a role in MyD88-induced IFNA2 activation and IL-8 secretion. (PubMed id 22332739)1 Charlaftis N....Morley P.J. (Biotechnol. Appl. Biochem. 2012)
    721. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    722. Modulatory effect of fenofibrate on endothelial production of neutrophil chemokines IL-8 and ENA-78. (PubMed id 22274300)1 Price E.T....Zineh I. (Cardiovasc Drugs Ther 2012)
    723. The expression of interleukin (IL)-6, IL-8, and their receptors in fallopian tubes with ectopic tubal gestation. (PubMed id 22763101)1 Balasubramaniam E.S....El-Bahrawy M. (Fertil. Steril. 2012)
    724. Regulation of CXCL8/IL-8 expression by zonula occludens-1 in human breast cancer cells. (PubMed id 22064657)1 Brysse A....Gilles C. (Mol. Cancer Res. 2012)
    725. H. pylori induces the expression of Hath1 in gastric epithelial cells via interleukin-8/STAT3 phosphorylation while suppressing Hes1. (PubMed id 22786753)1 Zhang X....Wang R. (J. Cell. Biochem. 2012)
    726. Neuronal apoptosis by HIV-1 Vpr: contribution of proinflammatory molecular networks from infected target cells. (PubMed id 22727020)1 Guha D....Ayyavoo V. (J Neuroinflammation 2012)
    727. Interleukin-8 is associated with adhesion, migration and invasion in human gastric cancer SCG-7901 cells. (PubMed id 21191670)1 Ju D....Wei P. (Med. Oncol. 2012)
    728. Interleukin-8 gene regulation in epithelial cells by Vibrio cholerae: role of multiple promoter elements, adherence and motility of bacteria and host MAPKs. (PubMed id 22348317)1 Sarkar M....Chaudhuri K. (FEBS J. 2012)
    729. Association of matrix metalloproteinase (MMP)-1, 3, 9, interleukin (IL)-2, 8 and cyclooxygenase (COX)-2 gene polymorphisms with chronic periodontitis in a Chinese population. (PubMed id 22819245)1 Li G....Chow L.W. (Cytokine 2012)
    730. [Influence of IFN on expression of chemokine receptor CXCR1, CXCR2 and their ligand IL-8 in the patients with chronic hepatitis B]. (PubMed id 22482416)1 Bi H.J....Liu J.H. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012)
    731. Modulation of CXCL-8 expression in human melanoma cells regulates tumor growth, angiogenesis, invasion, and metastasis. (PubMed id 23342280)1 Wu S....Singh R.K. (Cancer Med 2012)
    732. The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells. (PubMed id 22048642)1 Lau W.K....Mak J.C. (Toxicol. Sci. 2012)
    733. Leukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products. (PubMed id 22215047)1 Nam Y.H....Shin M.H. (Inflamm. Res. 2012)
    734. Correlation of angiogenic cytokines-leptin and IL-8 in stage, type and presentation of endometriosis. (PubMed id 21848410)1 Malhotra N....Kumar S. (Gynecol. Endocrinol. 2012)
    735. Interleukin 8 gene 2767 A/G polymorphism is associated with increased risk of nephritis in children with Henoch-SchAPnlein purpura. (PubMed id 21240497)1 Tabel Y....Berdeli A. (Rheumatol. Int. 2012)
    736. Impact of interleukin-8 gene polymorphisms and environmental factors on oral cancer susceptibility in Taiwan. (PubMed id 22151543)1 Liu C.M....Chien M.H. (Oral Dis 2012)
    737. GEF-H1-RhoA signaling pathway mediates LPS-induced NF-I_B transactivation and IL-8 synthesis in endothelial cells. (PubMed id 22226472)1 Guo F....Huan J. (Mol. Immunol. 2012)
    738. Effect of Helicobacter pylori cdrA on interleukin-8 secretions and nuclear factor kappa B activation. (PubMed id 22346248)1 Takeuchi H....Sugiura T. (World J. Gastroenterol. 2012)
    739. Chemokines as markers of local inflammation and angiogenesis in patients with chronic subdural hematoma: a prospective study. (PubMed id 22037980)1 Stanisic M....Saehle T. (Acta Neurochir (Wien) 2012)
    740. Prostaglandin E2 enhances interleukin-8 production via EP4 receptor in human pulmonary microvascular endothelial cells. (PubMed id 22080750)1 Aso H....Hasegawa Y. (Am. J. Physiol. Lung Cell Mol. Physiol. 2012)
    741. Insulin-like growth factor-1 cytokines cross-talk in type 1 diabetes mellitus: relationship to microvascular complications and bone mineral density. (PubMed id 22513191)1 AboElAsrar M.A....Omar A.M. (Cytokine 2012)
    742. Association of serum levels of polychlorinated biphenyls with IL-8 mRNA expression in blood samples from asthmatic and non-asthmatic Japanese children. (PubMed id 22326254)1 Tsuji M....Matsumura F. (Chemosphere 2012)
    743. Findings related to IL-8 and IL-10 gene polymorphisms in a Mexican patient population with irritable bowel syndrome infected with Blastocystis. (PubMed id 22287022)1 Olivo-Diaz A....Maravilla P. (Parasitol. Res. 2012)
    744. Upregulation of chemokines and their receptors in Duchenne muscular dystrophy: potential for attenuation of myofiber necrosis. (PubMed id 23225384)1 De Paepe B....De Bleecker J.L. (amp 2012)
    745. Interleukin-8 and -10 gene polymorphisms in irritable bowel syndrome. (PubMed id 22740130)1 Romero-Valdovinos M....Olivo-DA-az A. (Mol. Biol. Rep. 2012)
    746. Effect of berberine on proinflammatory cytokine production by ARPE-19 cells following stimulation with tumor necrosis factor-I+. (PubMed id 22427564)1 Wang Q....Yang P. (amp 2012)
    747. High TNF-alpha and IL-8 levels predict low blood dendritic cell counts in primary cytomegalovirus infection. (PubMed id 22257833)1 Varani S....SAPderberg-NauclAcr C. (J. Clin. Virol. 2012)
    748. Protein kinase A enhances lipopolysaccharide-induced IL-6, IL-8, and PGEa88 production by human gingival fibroblasts. (PubMed id 22452847)1 Ara T....Miyazawa H. (J Negat Results Biomed 2012)
    749. Interleukin 6 and interleukin 8 play important roles in systemic inflammatory response syndrome of meconium peritonitis. (PubMed id 22068677)1 Kanamori Y....Iwanaka T. (Surg. Today 2012)
    750. Oncostatin M decreases interleukin-1 I^ secretion by human synovial fibroblasts and attenuates an acute inflammatory reaction in vivo. (PubMed id 21854541)1 Dumas A....Pouliot M. (J. Cell. Mol. Med. 2012)
    751. Association of interleukin-6 and interleukin-8 with poor prognosis in elderly patients with chronic lymphocytic leukemia. (PubMed id 22475215)1 Yoon J.Y....Johnston J.B. (amp 2012)
    752. Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8. (PubMed id 22696056)1 Toosi S....Manga P. (J. Invest. Dermatol. 2012)
    753. Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters. (PubMed id 23168996)1 Isung J....Jokinen J. (Transl Psychiatry 2012)
    754. The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-I_B activity by blocking ubiquitination mediated proteasomal degradation of II_BI+ in human hepatoma cells. (PubMed id 22590978)1 Surjit M....Lal S.K. (BMC Biochem. 2012)
    755. Cytokines induced neutrophil extracellular traps formation: implication for the inflammatory disease condition. (PubMed id 23110185)1 Keshari R.S....Dikshit M. (PLoS ONE 2012)
    756. Elevated interleukin 8 and T-helper 1 and T-helper 17 cytokine levels prior to antiretroviral therapy in participants who developed immune reconstitution inflammatory syndrome during ACTG A5164. (PubMed id 23002445)1 Grant P.M....Sereti I. (J. Infect. Dis. 2012)
    757. HIV-1 matrix protein p17 binds to the IL-8 receptor CXCR1 and shows IL-8-like chemokine activity on monocytes through Rho/ROCK activation. (PubMed id 22262769)1 Giagulli C....Caruso A. (Blood 2012)
    758. Serial examination of serum IL-8, IL-10 and IL-1Ra levels is significant in neonatal seizures induced by hypoxic-ischaemic encephalopathy. (PubMed id 22537067)1 Youn Y.A....Lee I.G. (Scand. J. Immunol. 2012)
    759. Bradykinin- and lipopolysaccharide-induced bradykinin B2 receptor expression, interleukin 8 release and &quot;nitrosative stress&quot; in bronchial epithelial cells BEAS-2B: role for neutrophils. (PubMed id 22935637)1 Ricciardolo F.L....De Rose V. (Eur. J. Pharmacol. 2012)
    760. DNA promoter methylation status and protein expression of interleukin-8 in human colorectal adenocarcinomas. (PubMed id 22108905)1 Dimberg J....Matussek A. (Int J Colorectal Dis 2012)
    761. Chios mastic fractions in experimental colitis: implication of the nuclear factor I_B pathway in cultured HT29 cells. (PubMed id 22891614)1 Papalois A....Andrikopoulos N.K. (J Med Food 2012)
    762. Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner. (PubMed id 22626465)1 Terazawa S....Imokawa G. (Exp. Dermatol. 2012)
    763. Suppression of MIP-2 or IL-8 production by annexins A1 and A4 during coculturing of macrophages with late apoptotic human peripheral blood neutrophils. (PubMed id 22056994)1 Iwasa T....Kobayashi Y. (Biochim. Biophys. Acta 2012)
    764. Double-stranded RNA induces IL-8 and MCP-1 gene expression via TLR3 in HaCaT-keratinocytes. (PubMed id 22762377)1 Voss A....Kerkhoff C. (amp 2012)
    765. Ovarian endometrioma but not deep infiltrating endometriosis is associated with increased serum levels of interleukin-8 and interleukin-6. (PubMed id 22819248)1 Carmona F....Balasch J. (J. Reprod. Immunol. 2012)
    766. Upregulation of IL-6, IL-8 and CXCL-1 production in dermal fibroblasts by normal/malignant epithelial cells in vitro: Immunohistochemical and transcriptomic analyses. (PubMed id 23043537)1 KolA!A9 M....Smetana K. (Biol. Cell 2012)
    767. The lL-8 and IL-13 gene polymorphisms in inflammatory bowel disease and colorectal cancer. (PubMed id 22741617)1 Walczak A....Majsterek I. (DNA Cell Biol. 2012)
    768. Interleukin-8 is the single most up-regulated gene in whole genome profiling of H. pylori exposed gastric epithelial cells. (PubMed id 22248188)1 Eftang L.L....TannA ( 2012)
    769. Characterization of the interaction of interleukin-8 with hyaluronan, chondroitin sulfate, dermatan sulfate and their sulfated derivatives by spectroscopy and molecular modeling. (PubMed id 21873605)1 Pichert A....Pisabarro M.T. (Glycobiology 2012)
    770. Adipose tissue IL-8 is increased in normal weight women after menopause and reduced after gastric bypass surgery in obese women. (PubMed id 22168600)1 Alvehus M....Olsson T. (Clin. Endocrinol. (Oxf) 2012)
    771. Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids. (PubMed id 22964303)1 Grosse J....Grimm D. (FASEB J. 2012)
    772. Interleukin-8 associates with adhesion, migration, invasion and chemosensitivity of human gastric cancer cells. (PubMed id 22408359)1 Kuai W.X....Tang X.J. (World J. Gastroenterol. 2012)
    773. Risk modification of colorectal cancer susceptibility by interleukin-8 -251T&gt;A polymorphism in Malaysians. (PubMed id 22690076)1 Mustapha M.A....Ankathil R. (World J. Gastroenterol. 2012)
    774. Src homology-2 domain-containing protein tyrosine phosphatase (SHP) 2 and p38 regulate the expression of chemokine CXCL8 in human astrocytes. (PubMed id 23029125)1 Mamik M.K. and Ghorpade A. (PLoS ONE 2012)
    775. 25-Hydroxycholesterol enhances cytokine release and Toll-like receptor 3 response in airway epithelial cells. (PubMed id 22849850)1 Koarai A....Ichinose M. (Respir. Res. 2012)
    776. BLCA-4 expression is related to MMP-9, VEGF, IL-1I+ and IL-8 in bladder cancer but not to PEDF, TNF-I+ or angiogenesis. (PubMed id 22197408)1 Feng C....Ding Q. (Pathol. Biol. 2012)
    777. ALK+ALCLs induce cutaneous, HMGB-1-dependent IL-8/CXCL8 production by keratinocytes through NF-I_B activation. (PubMed id 22394598)1 Dejean E....Meggetto F. (Blood 2012)
    778. An immunohistochemical study of interleukin-8 (IL-8) in breast cancer. (PubMed id 22244449)1 Zuccari D.A....Esteves J.L. (Acta Histochem. 2012)
    779. Comparative levels of macrophage migration inhibitory factor, procalcitonin, osteoprotegerin, interleukin-8, hs-C reactive protein, D-dimer in febrile neutropenia, newly diagnosed cancer patients, and infectious fever. (PubMed id 22079264)1 Bilgir O....Isikyakar T. (Transfus. Apher. Sci. 2012)
    780. CCR1-mediated STAT3 tyrosine phosphorylation and CXCL8 expression in THP-1 macrophage-like cells involve pertussis toxin-insensitive GI+(14/16) signaling and IL-6 release. (PubMed id 23125416)1 Lee M.M....Wong Y.H. (J. Immunol. 2012)
    781. MK2 posttranscriptionally regulates TNF-I+-induced expression of ICAM-1 and IL-8 via tristetraprolin in human pulmonary microvascular endothelial cells. (PubMed id 22268119)1 Shi J.X....Shi Y. (Am. J. Physiol. Lung Cell Mol. Physiol. 2012)
    782. Genetic variations of interleukin-8, CXCR1 and CXCR2 genes and risk of acute pyelonephritis in children. (PubMed id 22325052)1 Javor J....Liptakova A. (Int. J. Immunogenet. 2012)
    783. Role of mechanical stretching and lipopolysaccharide in early apoptosis and IL-8 of alveolar epithelial type II cells A549. (PubMed id 22840453)1 Ning Q.M....Zhao X.K. (Asian Pac J Trop Med 2012)
    784. Association of the CagA gene positive Helicobacter pylori and tissue levels of interleukin-17 and interleukin-8 in gastric ulcer patients. (PubMed id 23888551)1 El-Fakhry A.A....El-Naggar M.M. (Egypt J Immunol 2012)
    785. Native X-DING-CD4 protein secreted by HIV-1 resistant CD4+ T cells blocks activity of IL-8 promoter in human endothelial cells infected with enteric bacteria. (PubMed id 22031506)1 Ivanova A.... Simm M. (Inn. Immun. 2012)
    786. Trefoil factor 3 isolated from human breast milk downregulates cytokines (IL8 and IL6) and promotes human beta defensin (hBD2 and hBD4) expression in intestinal epithelial cells HT-29. (PubMed id 23198942)1 Barrera G.J....Gonzalez J.E. (Bosn J Basic Med Sci 2012)
    787. An NF-I_B-independent and Erk1/2-dependent mechanism controls CXCL8/IL-8 responses of airway epithelial cells to cadmium. (PubMed id 22094458)1 Cormet-Boyaka E....Boyaka P.N. (Toxicol. Sci. 2012)
    788. Residue 75 of interleukin-8 is crucial for its interactions with glycosaminoglycans. (PubMed id 23070988)1 Nordsieck K....Beck-Sickinger A.G. (Chembiochem 2012)
    789. BLT2 up-regulates interleukin-8 production and promotes the invasiveness of breast cancer cells. (PubMed id 23145117)1 Kim H....Kim J.H. (PLoS ONE 2012)
    790. IL-8 from local subcutaneous wounds regulates CD11b activation. (PubMed id 22229891)1 Lundahl J....Paulsson J.M. (Scand. J. Immunol. 2012)
    791. Elevated serum IL-8 is associated with the presence of hepatocellular carcinoma and independently predicts survival. (PubMed id 23072563)1 Welling T.H....Marrero J.A. (Cancer Invest. 2012)
    792. Enhanced chemosensitization in multidrug-resistant human breast cancer cells by inhibition of IL-6 and IL-8 production. (PubMed id 22923236)1 Shi Z....Huang R.P. (Breast Cancer Res. Treat. 2012)
    793. Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells. (PubMed id 22751949)1 Tabata S....Akiyama S. (Oncol. Rep. 2012)
    794. Serum biomarkers are similar in Churg-Strauss syndrome and hypereosinophilic syndrome. (PubMed id 22775568)1 Khoury P....Klion A.D. (Allergy 2012)
    795. Increased interleukin-8 in epithelial lining fluid of collapsed lungs during one-lung ventilation for thoracotomy. (PubMed id 22821380)1 Komatsu Y....Koizumi T. (Inflammation 2012)
    796. Effects of interleukin-8 on estradiol and progesterone production by bovine granulosa cells from large follicles and progesterone production by luteinizing granulosa cells in culture. (PubMed id 22129622)1 Shimizu T....Miyamoto A. (Cytokine 2012)
    797. Serum levels of Th17 associated cytokines in chronic hepatitis C virus infection. (PubMed id 22748467)1 Sousa G.M....Atta A.M. (Cytokine 2012)
    798. Adhesive interaction between peripheral blood mononuclear cells and activated platelets in the presence of anti-human leukocyte antigen Class I alloantibody causes production of IL-1I^ and IL-8. (PubMed id 21923858)1 Takahashi D....Ikeda H. (Vox Sang. 2012)
    799. Morphological analysis and interleukin release in human gingival fibroblasts seeded on different denture base acrylic resins. (PubMed id 23058014)1 Trubiani O....Caputi S. (Int J Immunopathol Pharmacol 2012)
    800. Lack of association between interleukin-8-251 T&gt;A polymorphism and colorectal cancer risk: a meta-analysis based on 3,019 cases and 3,984 controls. (PubMed id 23244113)1 Hu L.X....Pan Y.Y. (Asian Pac. J. Cancer Prev. 2012)
    801. Identification by DNA microarray of genes involved in Candida albicans-treated gingival epithelial cells. (PubMed id 22553989)1 Ikuta T....Abiko Y. (amp 2012)
    802. Inverse relationship between PSA and IL-8 in prostate cancer: an insight into a NF-I_B-mediated mechanism. (PubMed id 22403723)1 Xu Y....St Clair W.H. (PLoS ONE 2012)
    803. Pathogenesis of prostatic small cell carcinoma involves the inactivation of the P53 pathway. (PubMed id 22389383)1 Chen H....Huang J. (Endocr. Relat. Cancer 2012)
    804. AA genotype of IL-8 -251A/T is associated with low PaO(2)/FiO(2) in critically ill patients and with increased IL-8 expression. (PubMed id 22897124)1 Wacharasint P....Walley K.R. (Respirology 2012)
    805. Gene polymorphisms of NOD1 and interleukin-8 influence the susceptibility to erosive esophagitis in Helicobacter pylori infected Japanese population. (PubMed id 22902391)1 Oikawa T....Shimosegawa T. (Hum. Immunol. 2012)
    806. Glioblastoma cell-secreted interleukin-8 induces brain endothelial cell permeability via CXCR2. (PubMed id 23029099)1 Dwyer J....Gavard J. (PLoS ONE 2012)
    807. Met receptor tyrosine kinase signaling induces secretion of the angiogenic chemokine interleukin-8/CXCL8 in pancreatic cancer. (PubMed id 22815748)1 Hill K.S....Elferink L.A. (PLoS ONE 2012)
    808. CXCL8 enhances proliferation and growth and reduces apoptosis in endometrial stromal cells in an autocrine manner via a CXCR1-triggered PTEN/AKT signal pathway. (PubMed id 22563025)1 Li M.Q....Li D.J. (Hum. Reprod. 2012)
    809. Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption. (PubMed id 21925926)1 Hwang Y.S....Chung W.Y. (Oral Oncol. 2012)
    810. Lysophosphatidic acid receptor 2/3-mediated IL-8-dependent angiogenesis in cervical cancer cells. (PubMed id 21964883)1 Chen R.J....Lin M.C. (Int. J. Cancer 2012)
    811. Reduced nuclear factor-I_B repressing factor: a link toward systemic inflammation in COPD. (PubMed id 22441735)1 Lee K.Y....Kuo H.P. (Eur. Respir. J. 2012)
    812. miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene. (PubMed id 22292036)1 Zhou R....Chen X.M. (PLoS ONE 2012)
    813. Lack of association of -251T/A polymorphism in interleukin 8 gene with susceptibility to obsessive-compulsive disorder in Chinese Han population. (PubMed id 22609211)1 Liu S....Ma X. (Cytokine 2012)
    814. The diagnostic value of interleukin-6 and interleukin-8 for early prediction of bacteremia and sepsis in children with febrile neutropenia and cancer. (PubMed id 22367386)1 Urbonas V....TamulienA9 I. (J. Pediatr. Hematol. Oncol. 2012)
    815. Prostaglandin E2 modulates IL-8 expression through formation of a multiprotein enhanceosome in human colonic epithelial cells. (PubMed id 22531917)1 Srivastava V....Chadee K. (Eur. J. Immunol. 2012)
    816. Up-regulation of chemokine C-C ligand 2 (CCL2) and C-X-C chemokine 8 (CXCL8) expression by monocytes in chronic idiopathic urticaria. (PubMed id 22132892)1 Santos J.C....Sato M.N. (Clin. Exp. Immunol. 2012)
    817. The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment. (PubMed id 22140266)1 Gangavarapu P....Rajarathnam K. (J. Leukoc. Biol. 2012)
    818. Lipopolysaccharide induces cytokine production and decreases extravillous trophoblast invasion through a mitogen-activated protein kinase-mediated pathway: possible mechanisms of first trimester placental dysfunction. (PubMed id 22052387)1 Anton L....Elovitz M.A. (Hum. Reprod. 2012)
    819. The IL-8 gene polymorphisms and the risk of the hepatitis B virus/infected patients. (PubMed id 22335768)1 Qin X....Li S. (DNA Cell Biol. 2012)
    820. Effect of Helicobacter pylori eradication according to the IL-8-251 polymorphism in Koreans. (PubMed id 23091318)1 Kang H.Y....Song I.S. (J. Korean Med. Sci. 2012)
    821. Evidence of central inflammation in fibromyalgia-increased cerebrospinal fluid interleukin-8 levels. (PubMed id 22126705)1 Kadetoff D....Kosek E. (J. Neuroimmunol. 2012)
    822. Suppression of IL-8 production in gastric epithelial cells by MUC1 mucin and peroxisome proliferator-associated receptor-I^. (PubMed id 22766852)1 Park Y.S....Lillehoj E.P. (Am. J. Physiol. Gastrointest. Liver Physiol. 2012)
    823. Induction of interleukin-8 by Naegleria fowleri lysates requires activation of extracellular signal-regulated kinase in human astroglial cells. (PubMed id 22411631)1 Kim J.H....Shin H.J. (Parasitol. Res. 2012)
    824. Upregulation of thromboxane synthase mediates visfatin-induced interleukin-8 expression and angiogenic activity in endothelial cells. (PubMed id 22293189)1 Kim S.R....Bae M.K. (Biochem. Biophys. Res. Commun. 2012)
    825. Peroxisome proliferating activating receptor gamma-independent attenuation of interleukin 6 and interleukin 8 secretion from primary endometrial stromal cells by thiazolidinediones. (PubMed id 22192353)1 McKinnon B....Mueller M.D. (Fertil. Steril. 2012)
    826. NFI_B and AP-1 drive human myometrial IL8 expression. (PubMed id 22685373)1 Khanjani S....Bennett P.R. (Mediators Inflamm. 2012)
    827. The expression of interleukin-8 and interleukin-8 receptors in endometrial carcinoma. (PubMed id 22626766)1 Ewington L....El-Bahrawy M.A. (Cytokine 2012)
    828. Angiopoietin-1 but not angiopoietin-2 induces IL-8 synthesis and release by human neutrophils. (PubMed id 22015631)1 Neagoe P.E....Sirois M.G. (J. Cell. Physiol. 2012)
    829. Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes. (PubMed id 23251686)1 Shah A....Kumar A. (PLoS ONE 2012)
    830. Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells. (PubMed id 22983351)1 Moretto N....Facchinetti F. (Am. J. Physiol. Lung Cell Mol. Physiol. 2012)
    831. Combined effects of CXCL8 and CXCR2 gene polymorphisms on susceptibility to systemic sclerosis. (PubMed id 22763041)1 Salim P.H....Xavier R.M. (Cytokine 2012)
    832. CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling. (PubMed id 21994122)1 Tang K.H....Chan K.W. (Hepatology 2012)
    833. Interleukin-8 secretion by ovarian cancer cells increases anchorage-independent growth, proliferation, angiogenic potential, adhesion and invasion. (PubMed id 22579115)1 Wang Y....Meng X.Y. (Cytokine 2012)
    834. The role of IL-8 in the SDF-1I+/CXCR4-induced angiogenesis of laryngeal and hypopharyngeal squamous cell carcinoma. (PubMed id 22366438)1 Li K.C....Tan C.T. (Oral Oncol. 2012)
    835. Correlation between maternal inflammatory markers and fetomaternal adiposity. (PubMed id 22726456)1 Farah N....Turner M.J. (Cytokine 2012)
    836. Synergism between interleukin (IL)-17 and Toll-like receptor 2 and 4 signals to induce IL-8 expression in cystic fibrosis airway epithelial cells. (PubMed id 22466961)1 Mizunoe S....Kai H. (J. Pharmacol. Sci. 2012)
    837. Toll-like receptor 9 mediates oral bacteria-induced IL-8 expression in gingival epithelial cells. (PubMed id 21968713)1 Kim Y....Choi Y. (Immunol. Cell Biol. 2012)
    838. miRNA-146a expression positively regulates tumor necrosis factor-I+-induced interleukin-8 production in mesenchymal stem cells and differentiated lung epithelial-like cells. (PubMed id 22876745)1 Perng D.W....Lee Y.C. (Tissue Eng Part A 2012)
    839. HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2. (PubMed id 22904195)1 Caccuri F....Caruso A. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    840. Interleukin-8 derived from local tissue-resident stromal cells promotes tumor cell invasion. (PubMed id 21882260)1 Welte G....Song Y.H. (Mol. Carcinog. 2012)
    841. A meta-analysis of interleukin-8 -251 promoter polymorphism associated with gastric cancer risk. (PubMed id 22279522)1 Xue H....Huang G. (PLoS ONE 2012)
    842. Synergistic interactions between chemokine receptor elements in recognition of interleukin-8 by soluble receptor mimics. (PubMed id 22242662)1 Barter E.F. and Stone M.J. (Biochemistry 2012)
    843. Interleukin-8, a promising predictor for prognosis of pancreatic cancer. (PubMed id 22416189)1 Chen Y....Zhu M.H. (World J. Gastroenterol. 2012)
    844. Regulation of interleukin-1alpha and tumor necrosis factor-alpha-induced interleukin-8 production by amnion-derived (WISH) cells. (PubMed id 22675954)1 Kawano Y....Narahara H. (amp 2012)
    845. Excretory-secretory products of Giardia lamblia induce interleukin-8 production in human colonic cells via activation of p38, ERK1/2, NF-I_B and AP-1. (PubMed id 22224945)1 Lee H.Y....Park S.J. (Parasite Immunol. 2012)
    846. Dental implants stimulate expression of Interleukin-8 and its receptor in human blood--an in vitro approach. (PubMed id 22454194)1 Quabius E.S....Kern M. (J. Biomed. Mater. Res. Part B Appl. Biomater. 2012)
    847. Increase of toll-like receptor 4 but decrease of interleukin-8 mRNA expression among ischemic stroke patients under aspirin treatment. (PubMed id 22580394)1 Wu D....Hu C.J. (Clin. Biochem. 2012)
    848. Toll-like receptor 1/2 stimulation induces elevated interleukin-8 secretion in polymorphonuclear leukocytes isolated from preterm and term newborn infants. (PubMed id 21952587)1 Thornton N.L....Yost C.C. (Neonatology 2012)
    849. Seminal plasma induces angiogenic chemokine expression in cervical cancer cells and regulates vascular function. (PubMed id 22732298)1 Sales K.J....Katz A.A. (Biochim. Biophys. Acta 2012)
    850. Progressive increase of matrix metalloprotease-9 and interleukin-8 serum levels during carcinogenic process in human colorectal tract. (PubMed id 22848630)1 Biasi F....Poli G. (PLoS ONE 2012)
    851. Protein C activation peptide inhibits the expression of ICAM-1, VCAM-1, and interleukin-8 induced by TNF-I+ in human dermal microvascular endothelial cells. (PubMed id 23042271)1 Pina-Canseco M.d.e.l. .S....Zenteno E. (Folia Histochem. Cytobiol. 2012)
    852. -251 T/A polymorphism of the interleukin-8 gene and cancer risk: a HuGE review and meta-analysis based on 42 case-control studies. (PubMed id 21681427)1 Wang N....Li Y. (Mol. Biol. Rep. 2012)
    853. Haplotypes of susceptibility to chronic periodontitis in the Interleukin 8 gene do not influence protein level in the gingival crevicular fluid. (PubMed id 22877792)1 Corbi S.C....Scarel-Caminaga R.M. (Arch. Oral Biol. 2012)
    854. The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy. (PubMed id 22479352)1 Urbanek M....Lowe W.L. (PLoS ONE 2012)
    855. High baseline interleukine-8 level is an independent risk factor for the achievement of sustained virological response in chronic HCV patients. (PubMed id 21554996)1 Akbar H....Saleem S. (Infect. Genet. Evol. 2011)
    856. Phosphorylation of the epidermal growth factor receptor (EGFR) is essential for interleukin-8 release from intestinal epithelial cells in response to challenge with Escherichia coli O157 : H7 flagellin. (PubMed id 21546588)1 Fraser-Pitt D.J....Smith D.G. (Microbiology (Reading, Engl.) 2011)
    857. Genetic variations in the interleukin-6 and interleukin-8 genes and the interleukin-6 receptor gene in delirium. (PubMed id 21851175)1 van Munster Rooij S.E. (Rejuvenation Res 2011)
    858. SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. (PubMed id 21640118)1 Hwang W.L....Wang H.W. (Gastroenterology 2011)
    859. Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection. (PubMed id 21876747)1 Gehring A.J....Bertoletti A. (PLoS ONE 2011)
    860. Role of CCR2 and IL-8 in acute lung injury: a new mechanism and therapeutic target. (PubMed id 21348591)1 Shen Y....Wang X. (Expert Rev Respir Med 2011)
    861. Genetic polymorphisms and susceptibility to parenchymal renal infection among pediatric patients. (PubMed id 21042230)1 Cheng C.H....Lin T.Y. (Pediatr. Infect. Dis. J. 2011)
    862. Increased expression of S100 calcium binding protein A8 in GM-CSF-stimulated neutrophils leads to the increased expressions of IL-8 and IL-16. (PubMed id 21961943)1 Katano M....Kato T. (Clin. Exp. Rheumatol. 2011)
    863. Suppression of IL-8 production from airway cells by tiotropium bromide in vitro. (PubMed id 22003289)1 Suzaki I....Suzaki H. (Int J Chron Obstruct Pulmon Dis 2011)
    864. IL-8-251A&gt;T polymorphism is associated with breast cancer risk: a meta-analysis. (PubMed id 21468699)1 Huang Q....Yu J.H. (J. Cancer Res. Clin. Oncol. 2011)
    865. Hydrogen sulfide inhibits IL-8 expression in human keratinocytes via MAP kinase signaling. (PubMed id 21555999)1 Mirandola P....Vitale M. ( a journal of technical methods and pathology 2011)
    866. An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway. (PubMed id 21316925)1 Tsuji G....Furue M. (J. Dermatol. Sci. 2011)
    867. The role of IL-6, IL-8 and MCP-1 and their promoter polymorphisms IL-6 -174GC, IL-8 -251AT and MCP-1 -2518AG in the risk of venous thromboembolism: a case-control study. (PubMed id 21620438)1 Matos M.F....Morelli V.M. (Thromb. Res. 2011)
    868. Constitutive ERK activity induces downregulation of tristetraprolin, a major protein controlling interleukin8/CXCL8 mRNA stability in melanoma cells. (PubMed id 21593445)1 Bourcier C....PagA"s G. (Am. J. Physiol., Cell Physiol. 2011)
    869. Neutrophilic airways inflammation in lung cancer: the role of exhaled LTB-4 and IL-8. (PubMed id 21649887)1 Carpagnano G.E....Foschino-Barbaro M.P. (BMC Cancer 2011)
    870. Prognostic significance of IL-8-STAT-3 pathway in astrocytomas: correlation with IL-6, VEGF and microvessel morphometry. (PubMed id 21684758)1 Piperi C....Korkolopoulou P. (Cytokine 2011)
    871. Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis. (PubMed id 21330456)1 Reeves E.P....McElvaney N.G. (Am. J. Respir. Crit. Care Med. 2011)
    872. [Relationship between polymorphism of interleukin-8 and silicosis susceptibility]. (PubMed id 22214159)1 Sun D....Li C.L. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2011)
    873. Steroid-insensitive ERK1/2 activity drives CXCL8 synthesis and neutrophilia by airway smooth muscle. (PubMed id 21493783)1 Robins S....Rousseau S. (Am. J. Respir. Cell Mol. Biol. 2011)
    874. Mycoplasma pneumoniae induces interleukin-8 production via the epidermal growth factor receptor pathway. (PubMed id 21831204)1 Arae K....Taguchi H. (Microbiol. Immunol. 2011)
    875. Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models. (PubMed id 20648559)1 Ning Y....Lenz H.J. (Int. J. Cancer 2011)
    876. CXCL8 protects human neurons from amyloid-I^-induced neurotoxicity: relevance to Alzheimer's disease. (PubMed id 21840299)1 Ashutosh ....Ghorpade A. (Biochem. Biophys. Res. Commun. 2011)
    877. The dual role of CXCL8 in human CNS stem cell function: multipotent neural stem cell death and oligodendrocyte progenitor cell chemotaxis. (PubMed id 22407782)1 Kelland E.E....Lund B.T. (Glia 2011)
    878. Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathy. (PubMed id 21610567)1 Wakabayashi Y....Goto H. (Retina (Philadelphia, Pa.) 2011)
    879. miR-520b regulates migration of breast cancer cells by targeting hepatitis B X-interacting protein and interleukin-8. (PubMed id 21343296)1 Hu N....Ye L. (J. Biol. Chem. 2011)
    880. Effect of exposure conditions on SWCNT-induced inflammatory response in human alveolar epithelial cells. (PubMed id 21477645)1 Baktur R....Kwon S. (Toxicol In Vitro 2011)
    881. A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE. (PubMed id 21179067)1 Sandling J.K....SyvAonen A.C. (Eur. J. Hum. Genet. 2011)
    882. Down-regulation of cytokine-induced interleukin-8 requires inhibition of p38 mitogen-activated protein kinase (MAPK) via MAPK phosphatase 1-dependent and -independent mechanisms. (PubMed id 21454676)1 Dauletbaev N....Lands L.C. (J. Biol. Chem. 2011)
    883. Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-I+. (PubMed id 21573018)1 Kumar Pachathundikandi S....Backert S. (PLoS ONE 2011)
    884. Increased levels of human neutrophil peptides 1, 2, and 3 in peritoneal fluid of patients with endometriosis: association with neutrophils, T cells and IL-8. (PubMed id 21831449)1 Milewski A.8....Malejczyk J. (J. Reprod. Immunol. 2011)
    885. [Effects of NF-kappaB on the expression of IL-8 in human bronchial epithelial cells induced by cigarette smoke condensates]. (PubMed id 22043704)1 Zhang Q....Wu W. (Wei Sheng Yan Jiu 2011)
    886. Advanced glycation end products (AGEs) induce apoptosis via a novel pathway: involvement of Ca2+ mediated by interleukin-8 protein. (PubMed id 21862577)1 Mahali S....Manna S.K. (J. Biol. Chem. 2011)
    887. Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis. (PubMed id 21731723)1 Zimmermann H.W....Tacke F. (PLoS ONE 2011)
    888. [Association of IL-8 gene polymorphisms with inflammatory bowel disease in Chinese patients]. (PubMed id 22093783)1 Liang W.D....Bi Y.T. (Zhonghua Yi Xue Za Zhi 2011)
    889. Association of IL8 -251A/T, IL12B -1188A/C and TNF-I+ -238A/G polymorphisms with Tourette syndrome in a family-based association study in a Chinese Han population. (PubMed id 21443923)1 Liu S....Ma X. (Neurosci. Lett. 2011)
    890. Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus. (PubMed id 21959016)1 Liao Y....Liu D.X. (Virology 2011)
    891. Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways. (PubMed id 21873556)1 Balghi H....Hanrahan J.W. (FASEB J. 2011)
    892. Human CD4+ FOXP3+ regulatory T cells produce CXCL8 and recruit neutrophils. (PubMed id 21268001)1 Himmel M.E....Levings M.K. (Eur. J. Immunol. 2011)
    893. Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels are independently prognostic in primary myelofibrosis: a comprehensive cytokine profiling study. (PubMed id 21300928)1 Tefferi A....Pardanani A. (J. Clin. Oncol. 2011)
    894. A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. (PubMed id 20644561)1 Ho-Pun-Cheung A....Lopez-Crapez E. (Pharmacogenomics J. 2011)
    895. Modulation of NK cell autocrine-induced eosinophil chemotaxis by interleukin-15 and vitamin D(3): a possible NK-eosinophil crosstalk via IL-8 in the pathophysiology of allergic rhinitis. (PubMed id 21765616)1 El-Shazly A.E. and Lefebvre P.P. (Mediators Inflamm. 2011)
    896. Phospholipase C-I^3 is a key modulator of IL-8 expression in cystic fibrosis bronchial epithelial cells. (PubMed id 21411730)1 Bezzerri V....Cabrini G. (J. Immunol. 2011)
    897. NF-I_B feedback control of JNK1 activation modulates TRPV1-induced increases in IL-6 and IL-8 release by human corneal epithelial cells. (PubMed id 22171160)1 Wang Z....Reinach P.S. (Mol. Vis. 2011)
    898. Gene-gene interaction between tuberculosis candidate genes in a South African population. (PubMed id 20799037)1 de Wit E....Hoal E.G. (Mamm. Genome 2011)
    899. Novel roles for hypoxia and prostaglandin E2 in the regulation of IL-8 during endometrial repair. (PubMed id 21356375)1 Maybin J.A....Critchley H.O. (Am. J. Pathol. 2011)
    900. Bronchial epithelial cells release IL-6, CXCL1 and CXCL8 upon mast cell interaction. (PubMed id 22030312)1 Cao J....Zhang L. (Cytokine 2011)
    901. Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells. (PubMed id 21745629)1 Choi S.E....Lee K.W. (Nutr Res 2011)
    902. Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians. (PubMed id 20227257)1 Shaffer J.R....Donahue R.P. (Nutr Metab Cardiovasc Dis 2011)
    903. Sulforaphane inhibits de novo synthesis of IL-8 and MCP-1 in human epithelial cells generated by cigarette smoke extract. (PubMed id 21401388)1 Starrett W. and Blake D.J. (J Immunotoxicol 2011)
    904. Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8. (PubMed id 21282106)1 Bhattacharyya S....Biswas R. (J. Biol. Chem. 2011)
    905. Knockdown of CypA inhibits interleukin-8 (IL-8) and IL-8-mediated proliferation and tumor growth of glioblastoma cells through down-regulated NF-I_B. (PubMed id 20454998)1 Sun S....Chiu R. (J. Neurooncol. 2011)
    906. Control of cell migration and inflammatory mediators production by CORM-2 in osteoarthritic synoviocytes. (PubMed id 21961038)1 GarcA-a-Arnandis I....Alcaraz M.J. (PLoS ONE 2011)
    907. Interactions of interleukin-8 with the human chemokine receptor CXCR1 in phospholipid bilayers by NMR spectroscopy. (PubMed id 22019593)1 Park S.H....Opella S.J. (J. Mol. Biol. 2011)
    908. Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease. (PubMed id 21091908)1 Lammers K.M....Fasano A. (Immunology 2011)
    909. Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells. (PubMed id 21925169)1 Kim S....Nadel J.A. (Exp. Cell Res. 2011)
    910. Interleukin-8 overexpression in astrocytomas is induced by prostaglandin E2 and is associated with the transcription factors CCAAT/enhancer-binding protein-I^ and CCAAT/enhancer-binding homologous protein. (PubMed id 21471847)1 Venza M....Teti D. (Neurosurgery 2011)
    911. Thrombin induces NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells by a Rac1-dependent PI3K/Akt pathway. (PubMed id 21266580)1 Lin C.H....Chen B.C. (J. Biol. Chem. 2011)
    912. MAPK signaling pathways regulate IL-8 mRNA stability and IL-8 protein expression in cystic fibrosis lung epithelial cell lines. (PubMed id 20952496)1 Bhattacharyya S....Biswas R. (Am. J. Physiol. Lung Cell Mol. Physiol. 2011)
    913. ERI^ and PEA3 co-activate IL-8 expression and promote the invasion of breast cancer cells. (PubMed id 21266854)1 Chen Y....Shao Z.M. (amp 2011)
    914. Semaphorin 7A on keratinocytes induces interleukin-8 production by monocytes. (PubMed id 21524887)1 Kamata M....Sato S. (J. Dermatol. Sci. 2011)
    915. P. aeruginosa drives CXCL8 synthesis via redundant toll-like receptors and NADPH oxidase in CFTRa88F508 airway epithelial cells. (PubMed id 21176887)1 Roussel L....Rousseau S. (J. Cyst. Fibros. 2011)
    916. Low molecular weight hyaluronan, via AP-1 and NF-I_B signalling, induces IL-8 in transformed bronchial epithelial cells. (PubMed id 21989944)1 Ochoa C....Quinn D. (Swiss Med Wkly 2011)
    917. Expression of pigment epithelium-derived factor in bladder tumour is correlated with interleukin-8 yet not with interleukin-1I+. (PubMed id 21336718)1 Feng C....Wu Z. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2011)
    918. Oct4-related cytokine effects regulate tumorigenic properties of colorectal cancer cells. (PubMed id 22037460)1 Chang C.J....Lan Y.T. (Biochem. Biophys. Res. Commun. 2011)
    919. Interaction of aryl hydrocarbon receptor and NF-I_B subunit RelB in breast cancer is associated with interleukin-8 overexpression. (PubMed id 21640702)1 Vogel C.F....Matsumura F. (Arch. Biochem. Biophys. 2011)
    920. Effects of 15-deoxy-a88A^A^,A^a8'-prostaglandin Ja88 on the production of IL-8 and the expression of Toll-like receptor 2 in human primary keratinocytes stimulated with lipopolysaccharide. (PubMed id 20174873)1 Kim Y.I....Lee H.K. (Mol. Biol. Rep. 2011)
    921. PEDF inhibits IL8 production in prostate cancer cells through PEDF receptor/phospholipase A2 and regulation of NFI_B and PPARI^. (PubMed id 21570865)1 Hirsch J....Filleur S. (Cytokine 2011)
    922. Molecular dynamics simulations of CXCL-8 and its interactions with a receptor peptide, heparin fragments, and sulfated linked cyclitols. (PubMed id 21299226)1 Gandhi N.S. and Mancera R.L. (J Chem Inf Model 2011)
    923. The diagnostic value of CRP, IL-8, PCT, and sTREM-1 in the detection of bacterial infections in pediatric oncology patients with febrile neutropenia. (PubMed id 20803037)1 Miedema K.G....Tissing W.J. (Support Care Cancer 2011)
    924. A promoter SNP rs4073T&gt;A in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode. (PubMed id 21649933)1 Ahn M.H....Shim Y.S. (Respir. Res. 2011)
    925. Interleukin-8 induces the endothelial cell migration through the activation of phosphoinositide 3-kinase-Rac1/RhoA pathway. (PubMed id 21750647)1 Lai Y....Liu Y.F. (Int. J. Biol. Sci. 2011)
    926. Small intestinal bacterial overgrowth in nonalcoholic steatohepatitis: association with toll-like receptor 4 expression and plasma levels of interleukin 8. (PubMed id 21046243)1 Shanab A.A....Quigley E.M. (Dig. Dis. Sci. 2011)
    927. TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis. (PubMed id 21376140)1 Frade A.F....Goldberg A.C. (Infect. Genet. Evol. 2011)
    928. Systemic cytokine response in patients with community-acquired pneumonia. (PubMed id 20884746)1 Endeman H....Biesma D.H. (Eur. Respir. J. 2011)
    929. Mast cell-derived TNF-I+ and histamine modify IL-6 and IL-8 expression and release from cutaneous tumor cells. (PubMed id 21995333)1 Artuc M....Zuberbier T. (Exp. Dermatol. 2011)
    930. Serum TNF-I+, sTNFR1, IL-6, IL-8 and IL-10 levels in Weil's syndrome. (PubMed id 21316985)1 Kyriakidis I....Papa A. (Cytokine 2011)
    931. Lipopolysaccharide activated phosphatidylcholine-specific phospholipase C and induced IL-8 and MCP-1 production in vascular endothelial cells. (PubMed id 21413027)1 Zhang L....Miao J.Y. (J. Cell. Physiol. 2011)
    932. Inhibited proliferation of human lung fibroblasts by LPS is through IL-6 and IL-8 release. (PubMed id 21419646)1 Zhang J....Qu J.M. (Cytokine 2011)
    933. The role of cytokines IL-6 and IL-8 in the pathogenesis of spontaneous abortions. (PubMed id 21591973)1 Galazios G....Liberis V. (amp 2011)
    934. Chemokines plasma levels in preterm newborns of preeclamptic mothers. (PubMed id 21820916)1 Faulhaber F.R....Procianoy R.S. (Cytokine 2011)
    935. Pulmonary epithelial CCR3 promotes LPS-induced lung inflammation by mediating release of IL-8. (PubMed id 21660963)1 Li B....Bai C. (J. Cell. Physiol. 2011)
    936. Hepatocyte growth factor and keratinocyte growth factor enhance IL-1-induced IL-8 secretion through different mechanisms in Caco-2 epithelial cells. (PubMed id 21082280)1 Unger B.L. and McGee D.W. (amp 2011)
    937. Correlation of polymorphism of IL-8 and MMP-7 with occurrence and lymph node metastasis of early stage cervical cancer. (PubMed id 21336735)1 Wu S....Xie J. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2011)
    938. NTPDase1 controls IL-8 production by human neutrophils. (PubMed id 21670316)1 Kukulski F....SAcvigny J. (J. Immunol. 2011)
    939. Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, IL-29, IL-8, and cyclooxygenase-2. (PubMed id 21957142)1 Yu Y....Wu J. (J. Immunol. 2011)
    940. Haplotypes in the interleukin 8 gene and their association with chronic periodontitis susceptibility. (PubMed id 21188496)1 Scarel-Caminaga R.M....Cirelli J.A. (Biochem. Genet. 2011)
    941. Helicobacter pylori CagA-mediated IL-8 induction in gastric epithelial cells is cholesterol-dependent and requires the C-terminal tyrosine phosphorylation-containing domain. (PubMed id 22092715)1 Lai C.H....Wang W.C. (FEMS Microbiol. Lett. 2011)
    942. Polymorphisms in inflammatory response genes and their association with gastric cancer: A HuGE systematic review and meta-analyses. (PubMed id 21178102)4 Persson C....Forman D. (Am. J. Epidemiol. 2011)
    943. [Influence of genetic mutations on clinical presentation of subretinal neovascularization. Report 1: The impact of CFH and IL-8 genes polymorphism]. (PubMed id 21882633)1 Budzinskaia M.V....Galoian N.S. (Vestn Oftalmol 2011)
    944. The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth. (PubMed id 21398406)1 Singh R.K. and Lokeshwar B.L. (Cancer Res. 2011)
    945. Differential effects of multiplicity of infection on Helicobacter pylori-induced signaling pathways and interleukin-8 gene transcription. (PubMed id 20886283)1 Ritter B....Nourbakhsh M. (J. Clin. Immunol. 2011)
    946. CC and CXC chemokines induce airway smooth muscle proliferation and survival. (PubMed id 21368236)1 Halwani R....Hamid Q. (J. Immunol. 2011)
    947. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    948. Interleukin(IL)-4 promotion of CXCL-8 gene transcription is mediated by ERK1/2 pathway in human pulmonary artery endothelial cells. (PubMed id 21645924)1 Yang D.F....Lavoie J.P. (Mol. Immunol. 2011)
    949. Suppression of zinc finger protein 580 by high oxLDL/LDL-ratios is followed by enhanced expression of endothelial IL-8. (PubMed id 21310414)1 Hoffmann C.J....Zakrzewicz A. (Atherosclerosis 2011)
    950. Plantaricin A synthesized by Lactobacillus plantarum induces in vitro proliferation and migration of human keratinocytes and increases the expression of TGF-I^1, FGF7, VEGF-A and IL-8 genes. (PubMed id 21782870)1 Pinto D....De Angelis M. (Peptides 2011)
    951. Autophagy is required for toll-like receptor-mediated interleukin-8 production in intestinal epithelial cells. (PubMed id 21225224)1 Li Y.Y....Kinoshita Y. (Int. J. Mol. Med. 2011)
    952. IL-8 increases integrin expression and cell motility in human chondrosarcoma cells. (PubMed id 21590707)1 Lee C.Y....Tang C.H. (J. Cell. Biochem. 2011)
    953. Determination of strains of Helicobacter pylori and of polymorphism in the interleukin-8 gene in patients with stomach cancer. (PubMed id 21537542)1 Vinagre R.M....Martins L.C. (Arq Gastroenterol 2011)
    954. Interleukin-8 gene promoter polymorphism (rs4073) may contribute to chronic periodontitis. (PubMed id 21091348)1 Andia Souza A.P. (J. Periodontol. 2011)
    955. Increased interleukin (IL)-8 and decreased IL-17 production in chronic obstructive pulmonary disease (COPD) provoked by cigarette smoke. (PubMed id 21996014)1 Zhang X....He S. (Cytokine 2011)
    956. Relationship of interleukin-8 gene polymorphisms with hepatocellular carcinoma susceptibility and pathological development. (PubMed id 21780129)1 Chien M.H....Kuo W.H. (J Surg Oncol 2011)
    957. Plexin-B1 activates NF-I_B and IL-8 to promote a pro-angiogenic response in endothelial cells. (PubMed id 22028792)1 Yang Y.H....Basile J.R. (PLoS ONE 2011)
    958. Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells. (PubMed id 21297080)1 Perry M.M....Chung K.F. (Am. J. Respir. Cell Mol. Biol. 2011)
    959. The secret second life of an innocent chaperone: the story of CD74 and B cell/chronic lymphocytic leukemia cell survival. (PubMed id 21417823)1 Shachar I. and Haran M. (amp 2011)
    960. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65. (PubMed id 21697472)1 Li X....Lan K. (J. Virol. 2011)
    961. Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study. (PubMed id 21666788)1 Reina Ortiz M....Cooper P.J. (PLoS Negl Trop Dis 2011)
    962. NF-I_B and CREB are involved in IL-8 production of human neutrophils induced by Trichomonas vaginalis-derived secretory products. (PubMed id 22072831)1 Nam Y.H....Shin M.H. (Korean J. Parasitol. 2011)
    963. Biological activity of CXCL8 forms generated by alternative cleavage of the signal peptide or by aminopeptidase-mediated truncation. (PubMed id 21904597)1 Mortier A....Proost P. (PLoS ONE 2011)
    964. A new isoform of interleukin-32 suppresses IL-8 mRNA expression in the intestinal epithelial cell line HT-29. (PubMed id 21468596)1 Imaeda H....Fujiyama Y. (Mol Med Rep 2011)
    965. Interleukin-8 gene polymorphism is associated with acute coronary syndrome in the Chinese Han population. (PubMed id 21763153)1 Zhang X....Yan C. (Cytokine 2011)
    966. Myeloid angiogenic cells act as alternative M2 macrophages and modulate angiogenesis through interleukin-8. (PubMed id 21670847)1 Medina R.J....Stitt A.W. (Mol. Med. 2011)
    967. Urine IL-8 concentrations in infectious and non-infectious urinary tract conditions. (PubMed id 21603907)1 Bitsori M....Galanakis E. (Pediatr. Nephrol. 2011)
    968. IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. (PubMed id 21653678)1 Fernando R.I....Palena C. (Cancer Res. 2011)
    969. CXCR1 and CXCR2 silencing modulates CXCL8-dependent endothelial cell proliferation, migration and capillary-like structure formation. (PubMed id 21749879)1 Singh S....Singh R.K. (Microvasc. Res. 2011)
    970. Mycobacterium abscessus glycopeptidolipid prevents respiratory epithelial TLR2 signaling as measured by HI^D2 gene expression and IL-8 release. (PubMed id 22216191)1 Davidson L.B....Byrd T.F. (PLoS ONE 2011)
    971. Carcinoma-derived interleukin-8 disorients dendritic cell migration without impairing T-cell stimulation. (PubMed id 21423807)1 Alfaro C....Melero I. (PLoS ONE 2011)
    972. The role of phagocytosis in IL-8 production by human monocytes in response to lipoproteins on Staphylococcus aureus. (PubMed id 21333631)1 Kang H.J....Lee B.L. (Biochem. Biophys. Res. Commun. 2011)
    973. Interleukin-17F increases the secretion of interleukin-8 and the expression of cyclooxygenase 2 in endometriosis. (PubMed id 21601196)1 Hirata T....Taketani Y. (Fertil. Steril. 2011)
    974. CXCL8 and CCL5 expression in synovial fluid and blood serum in patients with osteoarthritis of the knee. (PubMed id 21336628)1 Pierzchala A.W....Hajduk G. (Arch. Immunol. Ther. Exp. (Warsz.) 2011)
    975. Hypoxia induces cysteine-rich 61, vascular endothelial growth factor, and interleukin-8 expressions in human nasal polyp fibroblasts: An implication of neutrophils in the pathogenesis of nasal polyposis. (PubMed id 21711965)1 Shun C.T....Liu C.M. (amp 2011)
    976. Shigella enterotoxin-2 is a type III effector that participates in Shigella-induced interleukin 8 secretion by epithelial cells. (PubMed id 21219446)1 FarfA!n M.J....Nataro J.P. (FEMS Immunol. Med. Microbiol. 2011)
    977. Prognostic significance of IL-6 and IL-8 ascites levels in ovarian cancer patients. (PubMed id 21619709)1 Lane D....PichAc A. (BMC Cancer 2011)
    978. Endothelial lipase (EL) and EL-generated lysophosphatidylcholines promote IL-8 expression in endothelial cells. (PubMed id 21130993)1 Riederer M....Frank S. (Atherosclerosis 2011)
    979. Mid-trimester amniotic fluid concentrations of the proinflammatory cytokines IL-6, IL-8, TNF-I+, and lipopolysaccharide binding protein in normal pregnancies: a prospective evaluation according to parity, gestational age, and fetal gender. (PubMed id 21702700)1 Bamberg C....Kalache K. (J Perinat Med 2011)
    980. Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway. (PubMed id 21193404)1 Cosgrove S....McElvaney N.G. (J. Biol. Chem. 2011)
    981. TNF-alpha and IL-8: serum levels and gene polymorphisms (-308G&gt;A and -251A&gt;T) are associated with classical biomarkers and medical history in children with sickle cell anemia. (PubMed id 21802960)1 Cajado C....Goncalves M.S. (Cytokine 2011)
    982. Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury. (PubMed id 20187772)1 Ross M.L....Peake J.M. (amp 2010)
    983. Paget's disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genes. (PubMed id 20709566)1 Corral-Gudino L....GonzA!lez-Sarmiento R. (Cytokine 2010)
    984. Adenosine modulates HIF-1{alpha}, VEGF, IL-8, and foam cell formation in a human model of hypoxic foam cells. (PubMed id 19834107)1 Gessi S....Borea P.A. (Arterioscler. Thromb. Vasc. Biol. 2010)
    985. [Induction of IL-8 by Chlamydia trachomatis through MAPK pathway rather than NF-kappaB pathway]. (PubMed id 20448351)1 Chen F....Yu P. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2010)
    986. Short-term IL-1beta blockade reduces monocyte CD11b integrin expression in an IL-8 dependent fashion in patients with type 1 diabetes. (PubMed id 20483667)1 Sanda S....Greenbaum C. (Clin. Immunol. 2010)
    987. Involvement of capsular polysaccharide via a TLR2/NF-kappaB pathway in Vibrio vulnificus-induced IL-8 secretion of human intestinal epithelial cells. (PubMed id 20198307)1 Lee B.C....Kim T.S. (Int. J. Mol. Med. 2010)
    988. [Expression of NF-kappaB and its downstream products in human umbilical vascular endothelial cells treated with paraquat]. (PubMed id 20506652)1 Yu H.F. and Nie H. (Sichuan Da Xue Xue Bao Yi Xue Ban 2010)
    989. ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production. (PubMed id 20181930)1 Mattaliano M.D....Paulsen J.E. (Am. J. Physiol., Cell Physiol. 2010)
    990. The role of endothelial interleukin-8/NADPH oxidase 1 axis in sepsis. (PubMed id 20518825)1 Miyoshi T....Uchiyama T. (Immunology 2010)
    991. Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6. (PubMed id 21048114)1 Eikawa S....Nakayama E. (J. Immunol. 2010)
    992. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    993. Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. (PubMed id 20103651)1 Huang D....Teh B.T. (Cancer Res. 2010)
    994. Co-elevated expression of hepatocyte growth factor and Interleukin-8 contributes to poor prognosis of patients with primary nasopharyngeal carcinoma. (PubMed id 19956874)1 Xie L.Q....Liang Y.J. (Oncol. Rep. 2010)
    995. Association of polymorphisms in proinflammatory cytokine genes with the development of oral cancer in Southern Thailand. (PubMed id 20133197)4 Kietthubthew S....Au W.W. (Int J Hyg Environ Health 2010)
    996. Mammalian target of rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function. (PubMed id 20410302)1 Tabatabaian F....Gomez-Cambronero J. (J. Biol. Chem. 2010)
    997. Engagement of toll-like receptor 3 induces vascular endothelial growth factor and interleukin-8 in human rheumatoid synovial fibroblasts. (PubMed id 21179282)1 Moon S.J....Park S.H. (Korean J. Intern. Med. 2010)
    998. Amino acids stimulate Akt phosphorylation, and reduce IL-8 production and NF-I_B activity in HepG2 liver cells. (PubMed id 20512787)1 van Meijl L.E....Mensink R.P. (amp 2010)
    999. Variants of ADAMTS1 modify the effectiveness of statins in reducing the risk of myocardial infarction. (PubMed id 21037509)1 Peters B.J....Maitland-van der Zee A.H. (Pharmacogenet. Genomics 2010)
    1000. The clinical Pseudomonas fluorescens MFN1032 strain exerts a cytotoxic effect on epithelial intestinal cells and induces Interleukin-8 via the AP-1 signaling pathway. (PubMed id 20698984)1 Madi A....Connil N. (BMC Microbiol. 2010)
    1001. Candida albicans releases soluble factors that potentiate cytokine production by human cells through a protease-activated receptor 1- and 2-independent pathway. (PubMed id 19858310)1 Cheng S.C....Netea M.G. (Infect. Immun. 2010)
    1002. Role of interleukin 8 in uterine natural killer cell regulation of extravillous trophoblast cell invasion. (PubMed id 20483454)1 De Oliveira L.G....Robson S.C. (Placenta 2010)
    1003. Standardized tape stripping prior to patch testing induces upregulation of Hsp90, Hsp70, IL-33, TNF-I+ and IL-8/CXCL8 mRNA: new insights into the involvement of 'alarmins'. (PubMed id 20731692)1 Dickel H....Skrygan M. (Contact Derm. 2010)
    1004. Oxidative stress enhances IL-8 and inhibits CCL20 production from intestinal epithelial cells in response to bacterial flagellin. (PubMed id 20595617)1 Ivison S.M....Steiner T.S. (Am. J. Physiol. Gastrointest. Liver Physiol. 2010)
    1005. A whole genome association study of mother-to-child transmission of HIV in Malawi. (PubMed id 20487506)1 Joubert B.R....Meshnick S.R. (Genome Med 2010)
    1006. Effect of natural commensal-origin DNA on toll-like receptor 9 (TLR9) signaling cascade, chemokine IL-8 expression, and barrier integritiy of polarized intestinal epithelial cells. (PubMed id 19714766)1 Ghadimi D....Schrezenmeir J. (Inflamm. Bowel Dis. 2010)
    1007. Lead contributes to arterial intimal hyperplasia through nuclear factor erythroid 2-related factor-mediated endothelial interleukin 8 synthesis and subsequent invasion of smooth muscle cells. (PubMed id 20595649)1 Zeller I....Bernhard D. (Arterioscler. Thromb. Vasc. Biol. 2010)
    1008. Macrophage migration inhibitory factor contributes angiogenesis by up-regulating IL-8 and correlates with poor prognosis of patients with primary nasopharyngeal carcinoma. (PubMed id 20872800)1 Liao B....Li B. (J Surg Oncol 2010)
    1009. Umbilical cord blood concentrations of IL-6, IL-8, and MMP-8 in pregnancy complicated by preterm premature rupture of the membranes and histological chorioamnionitis. (PubMed id 21196908)1 Andrys C....Kacerovsky M. (Neuro Endocrinol. Lett. 2010)
    1010. Cigarette smoke induces CXCL8 production by human neutrophils via activation of TLR9 receptor. (PubMed id 19840968)1 Mortaz E....Folkerts G. (Eur. Respir. J. 2010)
    1011. Pro-inflammatory interleukins in patients operated on for proximal femur fracture. (PubMed id 20218918)1 Kazmi S.S....rgensen J.J. (Scand. J. Clin. Lab. Invest. 2010)
    1012. Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors. (PubMed id 20102417)1 Kumar R....Salotra P. (Immunology 2010)
    1013. Integrin-mediated inhibition of interleukin-8 secretion from human neutrophils by collagen type I. (PubMed id 19995941)1 Quan W.Y....Nishida T. (J. Leukoc. Biol. 2010)
    1014. TGFI^1 induces IL-6 and inhibits IL-8 release in human bronchial epithelial cells: the role of Smad2/3. (PubMed id 20607798)1 Ge Q....Burgess J.K. (J. Cell. Physiol. 2010)
    1015. Cleavage of the NF-I_B family protein p65/RelA by the chlamydial protease-like activity factor (CPAF) impairs proinflammatory signaling in cells infected with Chlamydiae. (PubMed id 21041296)1 Christian J....HAocker G. (J. Biol. Chem. 2010)
    1016. Probing the role of CXC motif in chemokine CXCL8 for high affinity binding and activation of CXCR1 and CXCR2 receptors. (PubMed id 20630874)1 Joseph P.R....Rajarathnam K. (J. Biol. Chem. 2010)
    1017. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    1018. Stretch and inflammation-induced Pre-B cell colony-enhancing factor (PBEF/Visfatin) and Interleukin-8 in amniotic epithelial cells. (PubMed id 20598369)1 Kendal-Wright C.E....Bryant-Greenwood G.D. (Placenta 2010)
    1019. [Expressions of LL-37 and IL-8 in chronic sinusitis with nasal polyps]. (PubMed id 20556966)1 Xie D....Xie D. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2010)
    1020. [Expression of IL-8, SP-A and TGF-beta1 in bronchoalveolar lavage fluid of neonates with bronchopulmonary dysplasia]. (PubMed id 20540853)1 Liu D.Y....Feng Z.C. (Zhongguo Dang Dai Er Ke Za Zhi 2010)
    1021. A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. (PubMed id 19912257)1 Oshima N....Kinoshita Y. (Clin. Exp. Immunol. 2010)
    1022. The -251A&gt;T polymorphism of interleukin-8 is associated with longer mechanical ventilation and hospital staying after coronary surgery. (PubMed id 20206550)1 Wang Z....Wei M. (Cytokine 2010)
    1023. Induction of interleukin-8 from nasal epithelial cells during bacterial infection: the role of IL-8 for neutrophil recruitment in chronic rhinosinusitis. (PubMed id 20634942)1 Yoon B.N....Roh H.J. (Mediators Inflamm. 2010)
    1024. Role of inflammatory cells, cytokines and matrix metalloproteinases in neutrophil-mediated skin diseases. (PubMed id 20636397)1 Marzano A.V....Crosti C. (Clin. Exp. Immunol. 2010)
    1025. Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4-sulfate. (PubMed id 19346317)1 Bhattacharyya S....Tobacman J.K. (Am. J. Respir. Cell Mol. Biol. 2010)
    1026. Pneumococcal proteins PspA and PspC induce CXCL8 production in human neutrophils: implications in pneumococcal infections. (PubMed id 20670689)1 Cao J....Zhang X. (Microbes Infect. 2010)
    1027. Phospholipase D signaling pathway is involved in lung cancer-derived IL-8 increased osteoclastogenesis. (PubMed id 20106902)1 Hsu Y.L....Kuo P.L. (Carcinogenesis 2010)
    1028. Differential transcriptional regulation of IL-8 expression by human airway epithelial cells exposed to diesel exhaust particles. (PubMed id 19914270)1 Tal T.L....Samet J.M. (Toxicol. Appl. Pharmacol. 2010)
    1029. Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort. (PubMed id 20194818)1 Wright R.J....Gern J.E. (Am. J. Respir. Crit. Care Med. 2010)
    1030. IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells. (PubMed id 20400187)1 Weiss N....Cazaubon S. (J. Neuroimmunol. 2010)
    1031. [Relationship between serum IL-8 hsCRP, TNF-I+ and coronary lesions in CHD patients]. (PubMed id 21033124)1 Luo J.G. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010)
    1032. LTDa88 induces HB-EGF-dependent CXCL8 release through EGFR activation in human bronchial epithelial cells. (PubMed id 20889674)1 McGovern T....Martin J.G. (Am. J. Physiol. Lung Cell Mol. Physiol. 2010)
    1033. Differential effects of human neutrophil peptide-1 on growth factor and interleukin-8 production by human lung fibroblasts and epithelial cells. (PubMed id 20715983)1 Amenomori M....Kohno S. (Exp. Lung Res. 2010)
    1034. LPS-induced IL-8 activation in human intestinal epithelial cells is accompanied by specific histone H3 acetylation and methylation changes. (PubMed id 20546607)1 Angrisano T....Lembo F. (BMC Microbiol. 2010)
    1035. Respiratory echovirus 30 and coxsackievirus B5 can induce production of RANTES, MCP-1 and IL-8 by human bronchial epithelial cells. (PubMed id 20540976)1 Renois F....AndrAcoletti L. (Virus Res. 2010)
    1036. Tumor cell extravasation mediated by leukocyte adhesion is shear rate dependent on IL-8 signaling. (PubMed id 20379392)1 Liang S....Dong C. (amp 2010)
    1037. Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks. (PubMed id 19904283)1 Semple B.D....Morganti-Kossmann M.C. (J. Cereb. Blood Flow Metab. 2010)
    1038. [Overexpression of IL-8 and MMP-9 confer high malignant phenotype in patients with non-small cell lung cancer]. (PubMed id 20704821)1 Liu Z....Li F. (Zhongguo Fei Ai Za Zhi 2010)
    1039. Opisthorchis viverrini excretory/secretory products induce toll-like receptor 4 upregulation and production of interleukin 6 and 8 in cholangiocyte. (PubMed id 20887801)1 Ninlawan K....Sripa B. (Parasitol. Int. 2010)
    1040. Ketamine inhibits transcription factors activator protein 1 and nuclear factor-kappaB, interleukin-8 production, as well as CD11b and CD16 expression: studies in human leukocytes and leukocytic cell lines. (PubMed id 20185670)1 Welters I.D....Goumon Y. (Anesth. Analg. 2010)
    1041. Vitreous levels of VEGF, IL-8, and TNF-alpha in retinal detachment. (PubMed id 20465445)1 Rasier R....Bahcecioglu H. (Curr. Eye Res. 2010)
    1042. The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells. (PubMed id 19838218)1 Thobe M.N....Waltz S.E. (Oncogene 2010)
    1043. Pneumocystis cell wall beta-glucan stimulates calcium-dependent signaling of IL-8 secretion by human airway epithelial cells. (PubMed id 20626862)1 Carmona E.M....Limper A.H. (Respir. Res. 2010)
    1044. IL-8, IL-12 and IL-10 cytokines generation by neutrophils, fibroblasts and neutrophils- fibroblasts interaction in psoriasis. (PubMed id 20934961)1 Glowacka E....Zalewska A. (Adv Med Sci 2010)
    1045. Selective upregulation of interleukin-8 by human rhabdomyosarcomas in response to hypoxia: therapeutic implications. (PubMed id 19588509)1 Wysoczynski M....Ratajczak M.Z. (Int. J. Cancer 2010)
    1046. I+-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8. (PubMed id 21060150)1 Bergin D.A....McElvaney N.G. (J. Clin. Invest. 2010)
    1047. The CXC chemokine-degrading protease SpyCep of Streptococcus pyogenes promotes its uptake into endothelial cells. (PubMed id 20562101)1 Kaur S.J....Talay S.R. (J. Biol. Chem. 2010)
    1048. Gingko biloba extract reduces VEGF and CXCL-8/IL-8 levels in keratinocytes with cumulative effect with epigallocatechin-3-gallate. (PubMed id 19597830)1 Trompezinski S....Viac J. (Arch. Dermatol. Res. 2010)
    1049. Immunological parameters, including CXCL8 (IL-8) characterize cerebro- and cardiovascular events in patients with peripheral artery diseases. (PubMed id 20384872)1 Szomjak E....Szodoray P. (Scand. J. Immunol. 2010)
    1050. Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis. (PubMed id 20826776)1 Shahzad M.M....Sood A.K. (J. Biol. Chem. 2010)
    1051. Involvement of p120 in LPS-induced NF-kappaB activation and IL-8 production in human bronchial epithelial cells. (PubMed id 20172018)1 Wang M....Wu R. (Toxicol. Lett. 2010)
    1052. The human ovarian follicular fluid level of interleukin-8 is associated with follicular size and patient age. (PubMed id 19285667)1 Malizia B.A....Usheva A. (Fertil. Steril. 2010)
    1053. High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns. (PubMed id 20166885)1 Hussein M.H....Togari H. (Free Radic. Res. 2010)
    1054. Disulfide trapping of protein complexes on the yeast surface. (PubMed id 20047188)1 Lim K.H....Park S. (Biotechnol. Bioeng. 2010)
    1055. HIV-1 infection inhibits cytokine production in human thymic macrophages. (PubMed id 20817073)1 Rozmyslowicz T....Gaulton G.N. (Exp. Hematol. 2010)
    1056. Bacteria-derived hydrogen sulfide promotes IL-8 production from epithelial cells. (PubMed id 19932683)1 Chen W....Kawai T. (Biochem. Biophys. Res. Commun. 2010)
    1057. Serum eosinophil cationic protein and 27 cytokines/chemokines in acute exacerbation of childhood asthma. (PubMed id 20523065)1 Kato M....Hayashi Y. (Int. Arch. Allergy Immunol. 2010)
    1058. Serum interleukin-8 and insulin like growth factor-1 in Egyptian bladder cancer patients. (PubMed id 20571236)1 Mahmoud M.A....Elhadidy G.S. (Cancer Biomark 2010)
    1059. Transient receptor potential melastatin 2 is required for lipopolysaccharide-induced cytokine production in human monocytes. (PubMed id 20107186)1 Wehrhahn J....Hauschildt S. (J. Immunol. 2010)
    1060. HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-I_B pathway and can be silenced by gp120-specific siRNA. (PubMed id 21190575)1 Shah A. and Kumar A. (J Neuroinflammation 2010)
    1061. Thromboxane A(2) increases endothelial permeability through upregulation of interleukin-8. (PubMed id 20510674)1 Kim S.R....Bae M.K. (Biochem. Biophys. Res. Commun. 2010)
    1062. Peroxisome proliferator-activated receptor {delta} activators induce IL-8 expression in nonstimulated endothelial cells in a transcriptional and posttranscriptional manner. (PubMed id 20592029)1 Meissner M....Kaufmann R. (J. Biol. Chem. 2010)
    1063. Regulation of IL-8 production by complement-activated product, C5a, in vitro and in vivo during sepsis. (PubMed id 20591742)1 Wang L....Li Y. (Clin. Immunol. 2010)
    1064. HIF-1alpha mediates the induction of IL-8 and VEGF expression on infection with Afa/Dr diffusely adhering E. coli and promotes EMT-like behaviour. (PubMed id 20039880)1 Cane G....Vouret-Craviari V. (Cell. Microbiol. 2010)
    1065. Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer. (PubMed id 20711410)1 Gannon P.O....Mes-Masson A.M. (PLoS ONE 2010)
    1066. Induction of IL-6 and IL-8 by house dust mite allergen Der p1 in cultured human nasal epithelial cells is associated with PAR/PI3K/NFkappaB signaling. (PubMed id 20733339)1 Shi J....Li H. ( journal for oto-rhino-laryngology and its related specialties 2010)
    1067. Positive transcription elongation factor b (P-TEFb) contributes to dengue virus-stimulated induction of interleukin-8 (IL-8). (PubMed id 20618343)1 Li L.L....Ping Y.H. (Cell. Microbiol. 2010)
    1068. Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-alpha in normal pregnancies and in pregnancies complicated by preeclampsia. (PubMed id 20441409)1 Tosun M....MalatyalioA9lu E. (amp 2010)
    1069. 17Beta-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor. (PubMed id 20378727)1 Chotirmall S.H....McElvaney N.G. (Am. J. Respir. Crit. Care Med. 2010)
    1070. Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma. (PubMed id 20829347)2 Park S.H.... Moon Y. (J. Biol. Chem. 2010)
    1071. Urinary levels of interleukin-6 and interleukin-8 in patients with vesicoureteral reflux and renal parenchymal scar. (PubMed id 20084405)1 Gokce I....Topuzoglu A. (Pediatr. Nephrol. 2010)
    1072. Anthrax lethal toxin impairs IL-8 expression in epithelial cells through inhibition of histone H3 modification. (PubMed id 19343203)1 Raymond B....Touqui L. (PLoS Pathog. 2009)
    1073. Tumor necrosis factor (TNF)-alpha-induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1. (PubMed id 19376732)1 O'Hara A.M....Crowe S.E. (Cytokine 2009)
    1074. Interstitial concentrations of adipokines in subcutaneous abdominal and femoral adipose tissue. (PubMed id 19376162)1 Nielsen N.B....Stallknecht B. (Regul. Pept. 2009)
    1075. Role of Tat protein in HIV neuropathogenesis. (PubMed id 19526283)1 Li W....Nath A. (Neurotox Res 2009)
    1076. Dynamic regulation of CXCR1 and CXCR2 homo- and heterodimers. (PubMed id 19890050)1 MartA-nez MuA+oz L....Mellado M. (J. Immunol. 2009)
    1077. Prostaglandin F(2alpha)-induced interleukin-8 production in human dental pulp cells is associated with MEK/ERK signaling. (PubMed id 19345795)1 Chang M.C....Jeng J.H. (J Endod 2009)
    1078. Adiponectin stimulates IL-8 production by rheumatoid synovial fibroblasts. (PubMed id 19013427)1 Kitahara K....Kawai S. (Biochem. Biophys. Res. Commun. 2009)
    1079. Regulation of chemokine production via oxidative pathway in HeLa cells. (PubMed id 20150959)1 Kina S....Sunakawa H. (Mediators Inflamm. 2009)
    1080. Nitroxide radical TEMPO reduces ozone-induced chemokine IL-8 production in lung epithelial cells. (PubMed id 19162161)1 Castagna R....Valacchi G. (Toxicol In Vitro 2009)
    1081. Serum tumour necrosis factor-alpha and interleukin-8 levels in acromegalic patients: acromegaly may be associated with moderate inflammation. (PubMed id 18673463)1 Arikan S....Gokalp D. (Clin. Endocrinol. (Oxf) 2009)
    1082. Identification of biologically active peptides that inhibit binding of human CXCL8 to its receptors from a random phage-epitope library. (PubMed id 19118103)1 Houimel M. and Mazzucchelli L. (J. Leukoc. Biol. 2009)
    1083. Evaluation of plasma interleukin-8 concentration in patients with prostate cancer and benign prostate hyperplasia. (PubMed id 19561378)1 Dehghani M....Shakeri S. (Iran J Immunol 2009)
    1084. Interleukin 8 is differently expressed and modulated by PAR-1 activation in early and late endothelial progenitor cells. (PubMed id 18657231)1 Smadja D.M....Gaussem P. (J. Cell. Mol. Med. 2009)
    1085. Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway. (PubMed id 19819266)1 Sales K.J....Jabbour H.N. (Biochim. Biophys. Acta 2009)
    1086. Sterile trauma to normal human dermis invariably induces IL1beta, IL6 and IL8 in an innate response to &quot;danger&quot;. (PubMed id 19734969)1 SjAPgren F. and Anderson C. (Acta Derm. Venereol. 2009)
    1087. Angiotensin type 1 receptor expression and interleukin-8 production in polymorphonuclear leukocytes of patients with peripheral arterial disease. (PubMed id 19755917)1 Marino F....Cosentino M. (J. Cardiovasc. Pharmacol. 2009)
    1088. Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-kappaB and MAPK pathways. (PubMed id 19726162)1 Grange P.A....Dupin N. (J. Dermatol. Sci. 2009)
    1089. Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells. (PubMed id 19176759)1 Hao Q....Tang H. (Am. J. Physiol., Cell Physiol. 2009)
    1090. Physiologic cold shock increases adherence of Moraxella catarrhalis to and secretion of interleukin 8 in human upper respiratory tract epithelial cells. (PubMed id 19835476)1 Spaniol V....Aebi C. (J. Infect. Dis. 2009)
    1091. HIV-1 mediated immune pathogenesis: spotlight on the role of viral protein R (Vpr). (PubMed id 19275586)1 Majumder B....Ayyavoo V. (Curr. HIV Res. 2009)
    1092. Cellular interaction regulates interleukin-8 secretion by granulosa-lutein cells and monocytes/macrophages. (PubMed id 19086996)1 PoA8eA8 A....FedorcsA!k P. (Am. J. Reprod. Immunol. 2009)
    1093. Difference in the regulation of IL-8 expression induced by uropathogenic E. coli between two kinds of urinary tract epithelial cells. (PubMed id 19799797)1 Tsai K.W....Chen C.N. (J. Biomed. Sci. 2009)
    1094. Neurotensin signaling induces intracellular alkalinization and interleukin-8 expression in human pancreatic cancer cells. (PubMed id 19393580)1 Olszewski U. and Hamilton G. (Mol Oncol 2009)
    1095. Induced interleukin-8 expression in gliomas by tumor-associated macrophages. (PubMed id 19156359)1 Hong T.M....Tsai J.C. (J. Neurooncol. 2009)
    1096. Human intestinal intraepithelial lymphocytes and epithelial cells coinduce interleukin-8 production through the CD2-CD58 interaction. (PubMed id 19109405)1 Ebert E.C....Praveen R. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009)
    1097. Airway inflammation and upregulation of beta2 Mac-1 integrin expression on circulating leukocytes of female ragpickers in India. (PubMed id 19372628)1 Ray M.R....Lahiri T. (J Occup Health 2009)
    1098. Extracellular ATP and P2 receptors are required for IL-8 to induce neutrophil migration. (PubMed id 19303321)1 Kukulski F....SAcvigny J. (Cytokine 2009)
    1099. Clearance of apoptotic neutrophils is diminished in cord blood monocytes and does not lead to reduced IL-8 production. (PubMed id 19668110)1 Gille C....Orlikowsky T.W. (Pediatr. Res. 2009)
    1100. Implications of Nef: host cell interactions in viral persistence and progression to AIDS. (PubMed id 20012528)1 Arhel N.J. and Kirchhoff F. (Curr. Top. Microbiol. Immunol. 2009)
    1101. Increase of inflammatory markers after indoor renovation activities: the LISA birth cohort study. (PubMed id 19496969)1 Herberth G....Lehmann I. (Pediatr Allergy Immunol 2009)
    1102. Mechanical stretch enhances IL-8 production in pulmonary microvascular endothelial cells. (PubMed id 19747898)1 Iwaki M....Hasegawa Y. (Biochem. Biophys. Res. Commun. 2009)
    1103. Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men. (PubMed id 19141999)4 Giedraitis V....Glaser A. (Dement Geriatr Cogn Disord 2009)
    1104. The UDP-glucose receptor P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-8. (PubMed id 19454705)1 Arase T....Maruyama T. (J. Immunol. 2009)
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