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IL8 Gene

protein-coding   GIFtS: 67
GCID: GC04P074595

Interleukin 8

  See IL8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 81 2     T-Cell Chemotactic Factor2 3
Granulocyte Chemotactic Protein 11 2 3     GCP12
Monocyte-Derived Neutrophil Chemotactic Factor1 2 3     LECT2
Monocyte-Derived Neutrophil-Activating Peptide1 2 3     LUCT2
Alveolar Macrophage Chemotactic Factor I1 2     LYNAP2
Beta Endothelial Cell-Derived Neutrophil Activating Peptide1 2     NAF2
Chemokine (C-X-C Motif) Ligand 81 2     NAP12
Lung Giant Cell Carcinoma-Derived Chemotactic Protein1 2     Beta-Thromboglobulin-Like Protein2
Lymphocyte Derived Neutrophil Activating Peptide1 2     emoctakin2
Neutrophil-Activating Peptide 11 2     interleukin-82
Tumor Necrosis Factor-Induced Gene 11 2     Small Inducible Cytokine Subfamily B, Member 82
CXCL82 3     Emoctakin3
GCP-12 3     IL-83
MDNCF2 3     C-X-C Motif Chemokine 83
MONAP2 3     Neutrophil-Activating Protein 13
NAP-12 3     Protein 3-10C3

External Ids:    HGNC: 60251   Entrez Gene: 35762   Ensembl: ENSG000001694297   OMIM: 1469305   UniProtKB: P101453   

Export aliases for IL8 gene to outside databases

Previous GC identifers: GC04P074845 GC04P075006 GC04P075072 GC04P074971 GC04P070417


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL8 Gene:
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major
mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a
chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis
of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members
of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. (provided by
RefSeq, Jul 2008)

GeneCards Summary for IL8 Gene:
IL8 (interleukin 8) is a protein-coding gene. Diseases associated with IL8 include bronchiolitis, and mycobacterium marinum. GO annotations related to this gene include interleukin-8 receptor binding and chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: IL8_HUMAN, P10145
Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is
also involved in neutrophil activation. It is released from several cell types in response to an inflammatory
stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity
on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to
IL-8(1-77), respectively

Gene Wiki entry for IL8 (Interleukin 8) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL8 gene promoter:
         GR   AML1a   HNF-4alpha2   NF-E2 p45   HNF-4alpha1   C/EBPalpha   GR-alpha   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL8 promoter sequence
   Search Chromatin IP Primers for IL8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13-q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13-q21

IL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL8 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074595:  view genomic region     (about GC identifiers)

Start:
74,606,223 bp from pter      End:
74,609,433 bp from pter
Size:
3,211 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IL8_HUMAN, P10145 (See protein sequence)
Recommended Name: Interleukin-8 precursor  
Size: 99 amino acids; 11098 Da
Subunit: Homodimer
10 PDB 3D structures from and Proteopedia for IL8 (see first 6):
1ICW (3D)        1IKL (3D)        1IKM (3D)        1IL8 (3D)        1ILP (3D)        1ILQ (3D)    
1QE6 (3D)        1ROD (3D)        2IL8 (3D)        3IL8 (3D)    
Secondary accessions: B2R4L8 Q6FGF6 Q6LAE6 Q96RG6 Q9C077 Q9UCE1 Q9UCR8 Q9UCR9 Q9UCS0
Alternative splicing: 2 isoforms:  P10145-1   P10145-2   

Explore the universe of human proteins at neXtProt for IL8: NX_P10145

Explore proteomics data for IL8 at MOPED

Post-translational modifications: 

  • Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral
    blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8.
    IL-8(6-77) is the most promiment form1
  • Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis,
    possibly through impaired chemokine clearance from the blood circulation1
  • Modification sites at neXtProt

  • See IL8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000575.1  
    ENSEMBL proteins: 
     ENSP00000306512   ENSP00000385908  
    Reactome Protein details: P10145

    IL8 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IL8 Protein
    R&D Systems Recombinant & Natural Proteins for IL8 (CXCL8/IL-8)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IL8
    OriGene Protein Over-expression Lysate for IL8
    OriGene MassSpec for IL8
    OriGene Custom Protein Services for IL8
    GenScript Purified and Recombinant Proteins for IL8
    Novus Biologicals IL8 Proteins
    Novus Biologicals IL8 Lysates
    Sino Biological Recombinant Protein for IL8
    Sino Biological Cell Lysate for IL8
    ProSpec Recombinant Protein for IL8
    Cloud-Clone Corp. Proteins for IL8

     
    eBioscience Proteins for IL8: (see all 3
                        Human IL-8 Recombinant Protein Carrier-Free 100 ug

     
    antibodies-online proteins for IL8 (130 products) 

     
    antibodies-online peptides for IL8

    IL8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL8
    R&D Systems Antibodies for IL8 (CXCL8/IL-8)
    OriGene Antibodies for IL8
    OriGene Custom Antibody Services for IL8
    Novus Biologicals IL8 Antibodies
    Abcam antibodies for IL8
    Cloud-Clone Corp. Antibodies for IL8
    ThermoFisher Antibody for IL8
    antibodies-online antibodies for IL8 (356 products) 

    IL8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL8
    R&D Systems Flow Cytometry Kits for IL8 (CXCL8/IL-8)         (see all)
    GenScript Custom Assay Services for IL8
    Enzo Life Sciences assays for IL8
    Cloud-Clone Corp. ELISAs for IL8
    Cloud-Clone Corp. CLIAs for IL8
    eBioscience ELISAs for IL8: (see all 7
                        Human IL-8 ELISA Ready-SET-Go! (To Be Discontinued. Refer to 2nd Generation RSG Version: cat. 88-8086) 2 x 96 tests
    antibodies-online kits for IL8 (94 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR028469 Interleukin-8
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P10145

    ProtoNet protein and cluster: P10145

    1 Blocks protein domain: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: IL8_HUMAN, P10145
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Find genes that share domains with IL8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL8_HUMAN, P10145
    Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is
    also involved in neutrophil activation. It is released from several cell types in response to an inflammatory
    stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity
    on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to
    IL-8(1-77), respectively
    Induction: By ER stress in a DDIT3/CHOP-dependent manner

         Genatlas biochemistry entry for IL8:
    interleukin 8 (see IMC2@),neutrophil activating peptide 1,monocyte-derived neutrophil chemotactic factor,with a
    direct growth potentiating activity in malignant mesothelioma

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005153interleukin-8 receptor binding IPI1840701
    GO:0005515protein binding IPI10880251
    GO:0008009chemokine activity TAS12782716
         
    Find genes that share ontologies with IL8           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for IL8:
     Increased cell death in breast  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il8):
     hematopoietic system  immune system 

    Find genes that share phenotypes with IL8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cxcl15tm1Lira for IL8

       genOway: Develop your customized and physiologically relevant rodent model for IL8

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL8:
    hsa-mir-146a-5p (MIRT004409), hsa-mir-124-3p (MIRT023079), hsa-mir-155-5p (MIRT020979), hsa-mir-204-5p (MIRT005832), hsa-mir-1 (MIRT024086), hsa-mir-335-5p (MIRT019032)

    Block miRNA regulation of human, mouse, rat IL8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL8 (see all 33):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-372 hsa-miR-93 hsa-miR-889 hsa-miR-302b
    SwitchGear 3'UTR luciferase reporter plasmidIL8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL8
    Predesigned siRNA for gene silencing in human, mouse, rat IL8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL8

    Clone
    Products:
         
    OriGene clones in human, mouse for IL8 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL8 (NM_000584)
    Sino Biological Human cDNA Clone for IL8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL8
    Addgene plasmids for IL8 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL8
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL8

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-13103 VA4-13193 VA6-13192) for IL8 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL8_HUMAN, P10145: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    cytoskeleton2
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IL8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL8 About   (see all 56)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    Regulation of toll-like receptor signaling pathway0.93
    3NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    NOD-like Receptor Signaling Pathways0.58
    4Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    Bacterial infections in CF airways0.78
    5Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81


    Find genes that share SuperPaths with IL8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for IL8
        NOD-like Receptor Signaling Pathways
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL8 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling

    Selected GeneGo (Thomson Reuters) Pathways for IL8 (see all 14)
        Immune response MIF-mediated glucocorticoid regulation
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Immune response TLR signaling pathways
    Apoptosis and survival Lymphotoxin-beta receptor signaling

    Selected BioSystems Pathways for IL8 (see all 15)
        EBV LMP1 signaling
    Senescence and Autophagy
    SIDS Susceptibility Pathways
    Spinal Cord Injury
    Toll-like receptor signaling pathway


    5 Reactome Pathways for IL8
        Peptide ligand-binding receptors
    Senescence-Associated Secretory Phenotype (SASP)
    Chemokine receptors bind chemokines
    G alpha (i) signalling events
    ATF4 activates genes


    Selected Kegg Pathways  (Kegg details for IL8) (see all 22):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    NF-kappa B signaling pathway
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL8 (see all 24): 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL8 (P101451, 3 ENSP000003065124) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR2P250251, 3, ENSP000003196354EBI-3917999,EBI-2835281 I2D: score=4 STRING: ENSP00000319635
    PF4P027763, ENSP000002960294I2D: score=3 STRING: ENSP00000296029
    MTDHQ86UE43, ENSP000003382354I2D: score=1 STRING: ENSP00000338235
    RPS3P233963, ENSP000002785724I2D: score=1 STRING: ENSP00000278572
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis TAS11483765
    GO:0002237response to molecule of bacterial origin IDA19912257
    GO:0006928cellular component movement TAS10820279
    GO:0006935chemotaxis TAS12782716
    GO:0006954inflammatory response TAS11483765

    Find genes that share ontologies with IL8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL8

    2 HMDB Compounds for IL8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Salbutamol(l)-albuterol (see all 97)18559-94-9--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    Selected Novoseek inferred chemical compound relationships for IL8 gene (see all 138)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 92.7 1369 9723955 (8), 17207890 (7), 10619832 (7), 16413378 (6) (see all 99)
    groalpha 86.1 191 11495082 (7), 9641651 (7), 17922696 (5), 9889409 (4) (see all 81)
    fmlp 79.7 471 7837814 (9), 16249234 (7), 15494208 (5), 9013980 (5) (see all 99)
    leukotriene b4 78.5 560 8003341 (9), 8973284 (5), 9482389 (5), 12149532 (5) (see all 99)
    vegf 76.4 1297 11234901 (9), 10334214 (9), 17349553 (8), 9457313 (8) (see all 99)
    endotoxin 74.4 268 2007851 (5), 11451261 (5), 18485432 (4), 16384605 (4) (see all 99)
    grogamma 72.8 23 8702798 (3), 15832427 (2), 9553055 (2), 10695618 (1) (see all 11)
    grobeta 68 26 10600366 (3), 8702798 (3), 15832427 (2), 9553055 (2) (see all 12)
    il 10 67.4 70 18363812 (4), 9543183 (2), 19723087 (2), 20041183 (2) (see all 56)
    lipoteichoic acid 67.3 89 10570304 (7), 16619004 (4), 8262617 (4), 19250704 (3) (see all 37)



    Find genes that share compounds with IL8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL8 gene: 
    NM_000584.3  

    Unigene Cluster for IL8:

    Interleukin 8
    Hs.624  [show with all ESTs]
    Unigene Representative Sequence: NM_000584
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307407(uc003hhe.3) ENST00000401931 ENST00000483500
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IL8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL8 (see all 33):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-372 hsa-miR-93 hsa-miR-889 hsa-miR-302b
    SwitchGear 3'UTR luciferase reporter plasmidIL8 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IL8
    Predesigned siRNA for gene silencing in human, mouse, rat IL8
    Clone
    Products:
         
    OriGene clones in human, mouse for IL8 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL8 (NM_000584)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL8
    Addgene plasmids for IL8 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL8
    OriGene qSTAR qPCR primer pairs in human, mouse for IL8
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IL8
      QuantiTect SYBR Green Assays in human, mouse, rat IL8
      QuantiFast Probe-based Assays in human, mouse, rat IL8
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-13103 VA4-13193 VA6-13192) for IL8 

    Additional mRNA sequence: 

    AK131067.1 AK311874.1 BC013615.1 BT007067.1 CR542151.1 M17017.1 M26383.1 Y00787.1 
    Z11686.1 

    Selected DOTS entries (see all 25):

    DT.92451091  DT.452985  DT.97822713  DT.121222191  DT.100764374  DT.121222188  DT.100890247  DT.121222199 
    DT.121222180  DT.100722366  DT.100890252  DT.121222165  DT.100890251  DT.100890257  DT.92451100  DT.92451101 
    DT.95366903  DT.100691364  DT.100842594  DT.100890241  DT.100890254  DT.121222196  DT.92451080  DT.92451094 

    Selected AceView cDNA sequences (see all 756):

    BM907296 AA362132 BQ101101 CR600500 AI346866 CR619554 AA362358 BU158818 
    BM887846 BM924085 AA381999 BX396678 AA381177 AW662358 AW780211 AA381931 
    CR601533 AA381625 BM128212 CD364559 AW662719 AA381584 BE042737 AW769268 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IL8    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
    SP1:                                                
    SP2:                    -                           
    SP3:                                                


    ECgene alternative splicing isoforms for IL8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAGCACT
    IL8 Expression
    About this image


    IL8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Mesenchymal Stem Cells
             Placenta-derived mesenchymal stem cells (family)
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Angiogenic cell precursor
             Endothelial-like cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
             Angiogenic cell precursor
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 4 entries
             Villous Cytotrophoblast Cells Chorionic Villus
             Placenta-derived mesenchymal stem cells (family)
    IL8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.624
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL8 (see all 24): 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for IL8 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il85 chemokine (C-X-C motif) ligand 15   --   5 (44.78 cM) 90794534 
    chicken
    (Gallus gallus)
    Aves IL86
    K606
    Gallus gallus interleukin 8-like 1 (IL8L1), mRNA.
    48(a)
    46(a)
    1 ↔ many
    1 ↔ many
    4(50355001-50359957)
    4(50342296-50345374)
    lizard
    (Anolis carolinensis)
    Reptilia IL86
    interleukin 8
    40(a)
    1 ↔ 1
    AAWZ02035874(23277-25185)


    ENSEMBL Gene Tree for IL8 (if available)
    TreeFam Gene Tree for IL8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL8 gene
    PPBP2  PF42  CXCL12  PF4V12  CXCL62  CXCL32  CXCL52  CXCL22  
    Selected SIMAP similar genes for IL8 using alignment to 2 protein entries:     IL8_HUMAN (see all proteins) (see all similar genes):
    CXCL6    CXCL5    PPBP    PF4    CXCL1    CXCL2
    CXCL12    CXCL3    PF4V1    CCL8    CCL3L1    CCL3L3
    CCL11    CCL18    CCL5    CXCL13    CXCL10    CCL2

    Find genes that share paralogs with IL8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL8 (see all 235)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017995791,2
    C--70419362(-) ATTCCC/TTTTTT 1 -- int10--------
    rs1429307391,2
    --74482423(+) AGCAAA/CGAAAC 1 -- us2k10--------
    rs1893147861,2
    C--74482435(+) TGGAGA/TTTTCT 1 -- us2k10--------
    rs1819367531,2
    --74482438(+) AGTTTC/TCTTTA 1 -- us2k10--------
    rs1510778081,2
    --74482464(+) TTACCA/TATCCG 1 -- us2k10--------
    rs1411041051,2
    C--74482562(+) ATTTCA/GTTGTC 1 -- us2k10--------
    rs22275271,2
    F--74482648(+) TTTGAT/AGTTGT 1 -- us2k12Minor allele frequency- A:0.02NS 86
    rs1859761031,2
    --74482749(+) TCATCA/GCTGTA 1 -- us2k10--------
    rs1906913091,2
    C--74482754(+) ACTGTA/GTTTTA 1 -- us2k10--------
    rs1451861541,2
    --74482816(+) TAAGTC/GAGGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL8 (74606223 - 74609433 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IL8: --
    Human Gene Mutation Database (HGMD): IL8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL8
    DNA2.0 Custom Variant and Variant Library Synthesis for IL8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146930    OMIM disorders: --

    Selected diseases for IL8 (see all 68):    
    About MalaCards
    bronchiolitis    mycobacterium marinum    lung giant cell carcinoma    spermatocele
    meningitis    sepsis    mycobacterium fortuitum    adult respiratory distress syndrome
    chorioamnionitis    bagassosis    alcoholic hepatitis    sepsis in premature infants
    neutrophil-specific granule deficiency    pneumonia    common cold    aspiration pneumonia
    recurrent corneal erosion    cryptogenic organizing pneumonia    urethritis    sinusitis

    13 diseases from the University of Copenhagen DISEASES database for IL8:
    Lung disease     Cancer     Gastritis     Cystic fibrosis
    Vascular disease     Periodontitis     Chorioamnionitis     Inflammatory bowel disease
    Arthritis     Mastitis     Psoriasis     Endometriosis
    Peptic ulcer

    Find genes that share disorders with IL8           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL8 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 91.7 3968 9462219 (9), 8601968 (6), 10740342 (5), 1702929 (4) (see all 99)
    inflammation 90.2 1154 12697917 (4), 10680520 (4), 15104334 (4), 15901266 (4) (see all 99)
    tumors 81.8 3953 11181444 (8), 8601968 (6), 12471616 (6), 16088182 (5) (see all 99)
    bronchoalveolar lavage fluid 72.9 158 7712280 (4), 10933164 (3), 16077402 (3), 15909061 (3) (see all 99)
    systemic inflammatory response syndrome 70.3 31 8143477 (2), 9558403 (2), 9038289 (2), 16227031 (2) (see all 21)
    pulmonary disease chronic obstructive 68 39 8563494 (2), 12915744 (2), 11108181 (2), 16181530 (2) (see all 27)
    sepsis 66.2 233 1612748 (6), 17368039 (5), 15730597 (5), 9120108 (4) (see all 99)
    cystic fibrosis 65.2 102 7940424 (6), 7639556 (3), 8476069 (3), 17880760 (2) (see all 65)
    rheumatoid arthritis 64.5 130 1932367 (2), 8961381 (2), 14750259 (2), 10437780 (2) (see all 94)
    airways disease 63.8 23 7927669 (2), 10417151 (1), 10460760 (1), 9199432 (1) (see all 14)

    Genetic Association Database (GAD): IL8
    Human Genome Epidemiology (HuGE) Navigator: IL8 (282 documents)

    Export disorders for IL8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL8 gene, integrated from 10 sources (see all 7249):
    (articles sorted by number of sources associating them with IL8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The neutrophil-activating proteins interleukin 8 and beta- thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. (PubMed id 2145175)1, 2, 9 van Damme J.... Billiau A. (Eur. J. Immunol. 1990)
    2. Polymorphisms of the IL-8 and CXCR2 genes are not associated with BehAset's disease. (PubMed id 15630732)1, 4, 9 Duymaz-Tozkir J....GA1l A. (J. Rheumatol. 2005)
    3. Lack of association of interleukin-6 and interleukin-8 gene polymorphisms in Chinese patients with systemic lupus erythematosus. (PubMed id 17115422)1, 4, 9 Huang C.M....Tsai F.J. (J. Clin. Lab. Anal. 2006)
    4. Polymorphisms in interleukin 8 and its receptors (IL8, IL8RA and IL8RB) and association of common IL8 receptor variants with peripheral blood eosinophil counts. (PubMed id 16897191)1, 4, 9 Cheong H.S....Park C.S. (J. Hum. Genet. 2006)
    5. Genetic variation in the interleukin-8 gene promoter and vaginal concentrations of interleukin-8 are not associated with bacterial vaginosis during pregnancy. (PubMed id 16038986)1, 4, 9 Diaz-Cueto L....Arechavaleta-Velasco F. (J. Reprod. Immunol. 2005)
    6. Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers. (PubMed id 15902922)1, 4, 9 GonzA!lez-Quintela A....Perez L.F. (Alcohol 2004)
    7. The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea. (PubMed id 19077731)1, 4, 9 Kang J.M....Song I.S. (J. Clin. Gastroenterol. 2009)
    8. Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. (PubMed id 16719905)1, 4, 9 SA!nchez E....Koeleman B.P. (BMC Med. Genet. 2006)
    9. Association of interleukin-8 with cachexia from patients with low-third gastric cancer. (PubMed id 20037740)1, 4, 9 Song B....Wang X. (Comp. Funct. Genomics 2009)
    10. T-251A polymorphism of IL-8 relating to the development of histological gastritis and G-308A polymorphism of TNF-alpha relating to the development of macroscopic erosion. (PubMed id 18301299)1, 4, 9 Szoke D....Tulassay Z. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3576 HGNC: 6025 AceView: IL8 Ensembl:ENSG00000169429 euGenes: HUgn3576
    ECgene: IL8 Kegg: 3576 H-InvDB: IL8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IL8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL8 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_8
    SeattleSNPshttp://pga.gs.washington.edu/data/il8/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL8 gene:
    Search GeneIP for patents involving IL8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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