Aliases for IL7R Gene
External Ids for IL7R Gene
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2014]
GeneCards Summary for IL7R Gene
IL7R (Interleukin 7 Receptor) is a Protein Coding gene. Diseases associated with IL7R include t-b+ severe combined immunodeficiency due to il-7ralpha deficiency and severe combined immune deficiency, autosomal recessive t cell-negative, b cell-positive, nk cell-positive, il7r-related. Among its related pathways are PI3K-Akt signaling pathway and Akt Signaling. GO annotations related to this gene include antigen binding and interleukin-7 receptor activity.
UniProtKB/Swiss-Prot for IL7R Gene
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP)