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IL7 Gene

protein-coding   GIFtS: 64
GCID: GC08M079587

Interleukin 7

  See IL7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 71 2
IL-72 3
interleukin-72

External Ids:    HGNC: 60231   Entrez Gene: 35742   Ensembl: ENSG000001044327   OMIM: 1466605   UniProtKB: P132323   

Export aliases for IL7 gene to outside databases

Previous GC identifers: GC08M078689 GC08M079682 GC08M079311 GC08M079694 GC08M079807 GC08M075134


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL7 Gene:
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the
hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor.
This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T
cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and
may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this
cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript
variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal
tissues has not been confirmed.(provided by RefSeq, Dec 2010)

GeneCards Summary for IL7 Gene:
IL7 (interleukin 7) is a protein-coding gene. Diseases associated with IL7 include natural killer cell leukemia, and lymphocytic choriomeningitis. GO annotations related to this gene include interleukin-7 receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IL7_HUMAN, P13232
Function: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is
important for proliferation during certain stages of B-cell maturation

Gene Wiki entry for IL7 (Interleukin 7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL7 gene promoter:
         STAT1   p53   GATA-3   AP-1   ATF-2   Evi-1   IRF-7A   FOXO1a   c-Jun   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL7 promoter sequence
   Search Chromatin IP Primers for IL7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12-q13   Ensembl cytogenetic band:  8q21.12   HGNC cytogenetic band: 8q12-q13

IL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M079587:  view genomic region     (about GC identifiers)

Start:
79,587,978 bp from pter      End:
79,717,758 bp from pter
Size:
129,781 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IL7_HUMAN, P13232 (See protein sequence)
Recommended Name: Interleukin-7 precursor  
Size: 177 amino acids; 20187 Da
3 PDB 3D structures from and Proteopedia for IL7:
1IL7 (3D)        3DI2 (3D)        3DI3 (3D)    
Secondary accessions: A0N0L3 Q5FBY5 Q5FBY9
Alternative splicing: 3 isoforms:  P13232-1   P13232-2   P13232-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL7: NX_P13232

Explore proteomics data for IL7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn95, Asn116, Asn141

  • See IL7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000871.1  NP_001186815.1  NP_001186816.1  NP_001186817.1  

    ENSEMBL proteins: 
     ENSP00000263851   ENSP00000430272   ENSP00000427750   ENSP00000428364   ENSP00000427800  
     ENSP00000438922   ENSP00000368408  
    Reactome Protein details: P13232

    IL7 Human Recombinant Protein Products:

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    Novus Biologicals IL7 Proteins
    Novus Biologicals IL7 Lysates
    Sino Biological Recombinant Protein for IL7
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IL7
    Cloud-Clone Corp. Proteins for IL7

     
    eBioscience Proteins for IL7: (see all 2
                        Human IL-7 Recombinant Protein 5 ug

     
    antibodies-online proteins for IL7 (104 products) 

     
    Search antibodies-online for peptides for IL7

    IL7 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    3 InterPro protein domains:
     IPR000226 IL-7/IL-9_fam
     IPR018049 IL-7/IL-9_CS
     IPR001181 IL-7

    Graphical View of Domain Structure for InterPro Entry P13232

    ProtoNet protein and cluster: P13232

    2 Blocks protein domains:
    IPB000226 Interleukin-7/interleukin-9
    IPB001181 Interleukin-7


    UniProtKB/Swiss-Prot: IL7_HUMAN, P13232
    Similarity: Belongs to the IL-7/IL-9 family


    Find genes that share domains with IL7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL7_HUMAN, P13232
    Function: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is
    important for proliferation during certain stages of B-cell maturation

         Genatlas biochemistry entry for IL7:
    interleukin 7,20.2kDa,stimulating the proliferation of lymphoid progenitor cells

         Summary: 
    During embryonic development, IL7 as signaling molecule affects the following cells:
    Blood: B-cell Progenitor Cells (Peripheral Blood)

    IL7 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                
    Blood: Natural killer-like cells, Natural killer-like cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005126cytokine receptor binding ----
    GO:0005139interleukin-7 receptor binding IEA--
    GO:0005515protein binding IPI8266077
    GO:0008083growth factor activity ISS--
         
    Find genes that share ontologies with IL7           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for IL7:
     Synthetic lethal with c-Myc af  Synthetic lethal with imatinib 

         3 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Il7):
     hematopoietic system  immune system  no phenotypic analysis 

    Find genes that share phenotypes with IL7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL7: Il7tm1Dnax Il7tm1Hms

       genOway: Develop your customized and physiologically relevant rodent model for IL7

    miRNA
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    miRTarBase miRNAs that target IL7:
    hsa-mir-215-5p (MIRT024567), hsa-mir-192-5p (MIRT026781), hsa-mir-124-3p (MIRT022978), hsa-mir-335-5p (MIRT018556)

    Block miRNA regulation of human, mouse, rat IL7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL7 (see all 14):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL7

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    Sino Biological Human cDNA Clone for IL7
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL7
    Addgene plasmids for IL7 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL7_HUMAN, P13232: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IL7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL7 About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types
    B-Cell Development0.00
    IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61


    Find genes that share SuperPaths with IL7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IL7
        IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-7 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL7 (see all 25)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling


    1 Reactome Pathway for IL7
        Interleukin-7 signaling


    4 Kegg Pathways  (Kegg details for IL7):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway
    Hematopoietic cell lineage

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL7 (see all 11): 
              Growth Factors in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for IL7 (P132321, 3 ENSP000002638514) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL7RP168711, 3, ENSP000003061574EBI-80516,EBI-80490 I2D: score=5 STRING: ENSP00000306157
    IL2RGP317851, 3EBI-80516,EBI-80475 I2D: score=5 
    JAK1ENSP000003432044STRING: ENSP00000343204
    JAK3ENSP000003916764STRING: ENSP00000391676
    CSF2ENSP000002968714STRING: ENSP00000296871
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002360T cell lineage commitment IEA--
    GO:0006955immune response ----
    GO:0006959humoral immune response TAS2643102
    GO:0007267cell-cell signaling TAS2643102
    GO:0008284positive regulation of cell proliferation TAS2643102

    Find genes that share ontologies with IL7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL7

    Selected Novoseek inferred chemical compound relationships for IL7 gene (see all 63)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 61.2 54 16011532 (11), 12634395 (6), 14516451 (3), 19700197 (3) (see all 26)
    tyrosine 44.3 46 7694866 (3), 1708885 (2), 12750561 (2), 7957877 (2) (see all 33)
    alpha-galactosylceramide 42.5 14 11150537 (3), 10715513 (3), 10594688 (3), 15368282 (1)
    methylcellulose 42.1 6 8172177 (1), 7566971 (1), 7686604 (1), 10210330 (1) (see all 5)
    hemocyanin 35.7 7 9815643 (1), 9111580 (1), 7615008 (1), 9935194 (1) (see all 7)
    ionomycin 34.8 3 16045733 (1), 1292630 (1)
    thymidine 31.8 10 8397935 (2), 8152260 (1), 15921626 (1), 9024505 (1) (see all 8)
    phosphatidylinositol 24.2 13 7522165 (2), 9614102 (1), 11739504 (1), 12354940 (1) (see all 7)
    il 10 22.4 4 19064561 (1), 10995008 (1), 16943231 (1), 19473542 (1)
    c-d4t 18.8 1 12470268 (1)



    Find genes that share compounds with IL7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL7 gene (4 alternative transcripts): 
    NM_000880.3  NM_001199886.1  NM_001199887.1  NM_001199888.1  

    Unigene Cluster for IL7:

    Interleukin 7
    Hs.591873  [show with all ESTs]
    Unigene Representative Sequence: BC047698
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523959 ENST00000519833 ENST00000263851(uc003ybg.3 uc022awh.1 uc022awi.1 uc022awj.1 uc003ybh.3)
    ENST00000518982(uc003ybi.3) ENST00000520269 ENST00000520215 ENST00000520317
    ENST00000521323 ENST00000541183 ENST00000379113
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate IL7 (see all 14):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y hsa-miR-3647-3p
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      QuantiTect SYBR Green Assays in human, mouse, rat IL7
      QuantiFast Probe-based Assays in human, mouse, rat IL7

    Additional mRNA sequence: 

    AB102879.1 AB102882.1 AB102883.1 AB102885.1 AB102893.1 AK226000.1 AK291538.1 BC032487.1 
    BC047698.1 GQ919059.1 J04156.1 

    8 DOTS entries:

    DT.453043  DT.101982641  DT.120632347  DT.120632372  DT.120632362  DT.100745646  DT.120632339  DT.305914 

    Selected AceView cDNA sequences (see all 33):

    CD013920 CD013921 AA683422 BX107087 CD013922 NM_000880 BC047698 CD013919 
    J04156 BM978895 CD013923 BX105178 AI797222 BC032487 BI520517 BI912381 
    AI688740 BU632596 BM919542 CB961906 BI869380 AA626244 AI539460 BX508877 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IL7    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6
    SP1:                                      -                                 
    SP2:                                -     -                                 
    SP3:                                      -           -     -               
    SP4:                                                                        


    ECgene alternative splicing isoforms for IL7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAAATTG
    IL7 Expression
    About this image


    IL7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 7
    IL7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591873
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL7 (see all 11): 
              Growth Factors in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for IL7
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    QuantiFast Probe-based Assays in human, mouse, rat IL7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL7 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il71 , 5 interleukin 71, 5 80.83(n)1
    69.93(a)1
      3 (2.02 cM)5
    161961  NM_008371.41  NP_032397.11 
     75720775 


    ENSEMBL Gene Tree for IL7 (if available)
    TreeFam Gene Tree for IL7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL7 (see all 1295)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1408168541,2
    --79644562(+) ATCGCA/CCCAGT 4 -- ds50010--------
    rs1884729331,2
    C--79644563(+) TCGCAC/TCAGTG 4 -- ds50010--------
    rs1501450791,2
    --79644574(+) AAGGTG/TAAATG 4 -- ds50010--------
    rs801057421,2
    F--79644649(+) CCAGAG/ACATCT 4 -- ds50011Minor allele frequency- A:0.10WA 118
    rs119860571,2
    C,H--79644680(+) CATCAG/TCACAT 4 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs1920053741,2
    --79644739(+) GCAATA/GCAAAC 4 -- ds50010--------
    rs1158264661,2
    C,F--79644860(+) TTTAAC/TATAGA 4 -- ds50011Minor allele frequency- T:0.03WA 118
    rs25837591,2
    C,F,A,H--79644964(+) TCTCAT/CCTTAA 4 -- ds500120Minor allele frequency- C:0.23NS EA NA WA 2340
    rs1388876321,2
    --79645102(+) TATAGA/TGTCAA 4 -- ut310--------
    rs1831882921,2
    --79645153(+) TATTAG/TTATCT 4 -- ut310--------

    HapMap Linkage Disequilibrium report for IL7 (79587978 - 79717758 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv891059CNV Loss21882294
    essv4456CNV CNV17122850

    Human Gene Mutation Database (HGMD): IL7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL7
    DNA2.0 Custom Variant and Variant Library Synthesis for IL7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146660    OMIM disorders: --

    12 diseases for IL7:    
    About MalaCards
    natural killer cell leukemia    lymphocytic choriomeningitis    lymphopenia    relapsing polychondritis
    cutaneous t cell lymphoma    pancreas adenocarcinoma    thyroid lymphoma    pre-b-cell acute lymphoblastic leukemia
    radiculopathy    variant creutzfeldt-jakob disease    lymphoblastic leukemia    malaria

    3 diseases from the University of Copenhagen DISEASES database for IL7:
    Lymphopenia     Leukemia     Human immunodeficiency virus infectious disease

    Find genes that share disorders with IL7           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL7 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    severe combined immunodeficiency, x-linked 86.8 36 8026467 (1), 8605322 (1), 14966353 (1), 7481768 (1) (see all 24)
    lymphopenia 66.3 39 15642146 (3), 10837414 (1), 16313348 (1), 16461915 (1) (see all 24)
    lymphoblastic leukemia acute 61.2 34 7535143 (2), 2189505 (2), 7596167 (2), 2388482 (2) (see all 20)
    necrosis 58.1 144 8943702 (4), 10438843 (2), 17448250 (2), 17185327 (2) (see all 99)
    severe combined immunodeficiency 56.5 6 15661025 (1), 7777571 (1), 12411295 (1), 8916956 (1) (see all 5)
    t-all 55.2 42 14607751 (5), 16019476 (4), 10891465 (4), 17296584 (3) (see all 14)
    leukemia 51.8 47 15949292 (3), 1996110 (2), 10210778 (2), 1921447 (2) (see all 32)
    hiv infections 50 50 19372891 (3), 12847229 (3), 11590518 (3), 9562375 (2) (see all 28)
    tumors 45.3 202 1617669 (4), 8943702 (4), 7856736 (3), 8894249 (3) (see all 99)
    immunodeficiency 45.3 43 15629410 (2), 15141001 (2), 19864382 (2), 17855550 (2) (see all 27)

    Genetic Association Database (GAD): IL7
    Human Genome Epidemiology (HuGE) Navigator: IL7 (14 documents)

    Export disorders for IL7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL7 gene, integrated from 10 sources (see all 1302):
    (articles sorted by number of sources associating them with IL7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. (PubMed id 19141282)1, 2, 9 McElroy C.A.... Walsh S.T. (Structure 2009)
    2. Genetic association analysis of the interleukin 7 gene (IL7) in multiple sclerosis. (PubMed id 17913246)1, 4, 9 Lundmark F....Hillert J. (J. Neuroimmunol. 2007)
    3. Comparative model building of interleukin-7 using interleukin-4 as a template: a structural hypothesis that displays atypical surface chemistry in helix D important for receptor activation. (PubMed id 10850801)1, 2, 9 Cosenza L.... Smith T.F. (Protein Sci. 2000)
    4. Disulfide bond assignment in human interleukin-7 by matrix-assisted laser desorption/ionization mass spectroscopy and site-directed cysteine to serine mutational analysis. (PubMed id 9407080)1, 2, 9 Cosenza L.... Murphy J.R. (J. Biol. Chem. 1997)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    7. An application of Random Forests to a genome-wide association dataset: methodological considerations &amp; new findings. (PubMed id 20546594)1, 4 Goldstein B.A....Barcellos L.F. (BMC Genet. 2010)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    9. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    10. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3574 HGNC: 6023 AceView: IL7 Ensembl:ENSG00000104432 euGenes: HUgn3574
    ECgene: IL7 Kegg: 3574 H-InvDB: IL7

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL7 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_7

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL7 gene:
    Search GeneIP for patents involving IL7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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