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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL7 Gene

protein-coding   GIFtS: 63
GCID: GC08M079587

Interleukin 7

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 71 2
IL-72 3
interleukin-72

External Ids:    HGNC: 60231   Entrez Gene: 35742   Ensembl: ENSG000001044327   OMIM: 1466605   UniProtKB: P132323   

Export aliases for IL7 gene to outside databases

Previous GC identifers: GC08M078689 GC08M079682 GC08M079311 GC08M079694 GC08M079807 GC08M075134


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL7 Gene:
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the
hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor.
This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T
cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and
may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this
cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript
variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal
tissues has not been confirmed.(provided by RefSeq, Dec 2010)

GeneCards Summary for IL7 Gene: 
IL7 (interleukin 7) is a protein-coding gene. Diseases associated with IL7 include t-lymphocytopenia, and natural killer cell leukemia, and among its related super-pathways are B-Cell Development and MIF Mediated Glucocorticoid Regulation. GO annotations related to this gene include growth factor activity and interleukin-7 receptor binding.

UniProtKB/Swiss-Prot: IL7_HUMAN, P13232
Function: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is
important for proliferation during certain stages of B-cell maturation

Gene Wiki entry for IL7 (Interleukin 7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL7 gene promoter:
         STAT1   p53   GATA-3   AP-1   ATF-2   Evi-1   IRF-7A   FOXO1a   c-Jun   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL7 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12-q13   Ensembl cytogenetic band:  8q21.12   HGNC cytogenetic band: 8q12-q13

IL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M079587:  view genomic region     (about GC identifiers)

Start:
79,587,978 bp from pter      End:
79,717,758 bp from pter
Size:
129,781 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL7_HUMAN, P13232 (See protein sequence)
Recommended Name: Interleukin-7 precursor  
Size: 177 amino acids; 20187 Da
Subcellular location: Secreted
3 PDB 3D structures from and Proteopedia for IL7:
1IL7 (3D)        3DI2 (3D)        3DI3 (3D)    
Secondary accessions: A0N0L3 Q5FBY5 Q5FBY9
Alternative splicing: 3 isoforms:  P13232-1   P13232-2   P13232-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL7: NX_P13232

Explore proteomics data for IL7 at MOPED 

IL7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IL7 Protein Expression

REFSEQ proteins (4 alternative transcripts): 
NP_000871.1  NP_001186815.1  NP_001186816.1  NP_001186817.1  

ENSEMBL proteins: 
 ENSP00000263851   ENSP00000430272   ENSP00000427750   ENSP00000428364   ENSP00000427800  
 ENSP00000438922   ENSP00000368408  
Reactome Protein details: P13232
Human Recombinant Protein Products for IL7: 
EMD Millipore Purified and/or Recombinant IL7 Protein
R&D Systems Recombinant & Natural Proteins for IL7 (IL-7)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for IL7
OriGene Custom MassSpec 
OriGene Custom Protein Services for IL7
GenScript Purified and Recombinant Proteins for IL7
Novus Biologicals IL7 Proteins
Novus Biologicals IL7 Lysates
Sino Biological Recombinant Protein for IL7
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for IL7
Cloud-Clone Corp. Proteins for IL7 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--

IL7 for ontologies           About GeneDecksing



IL7 Antibody Products: 
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LSBio Antibodies in human, mouse, rat for IL7 

Assay Products for IL7: 
Browse Kits and Assays available from EMD Millipore
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R&D Systems Flow Cytometry Kits for IL7 (IL-7)         (see all)
GenScript Custom Assay Services for IL7
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Cloud-Clone Corp. ELISAs for IL7 
Cloud-Clone Corp. CLIAs for IL7


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IL: Interleukins and interleukin receptors

3 InterPro protein domains:
 IPR000226 Interleukin_7_9
 IPR018049 Interleukin-7/-9_CS
 IPR001181 Interleukin-7

Graphical View of Domain Structure for InterPro Entry P13232

ProtoNet protein and cluster: P13232

2 Blocks protein domains:
IPB000226 Interleukin-7/interleukin-9
IPB001181 Interleukin-7


UniProtKB/Swiss-Prot: IL7_HUMAN, P13232
Similarity: Belongs to the IL-7/IL-9 family


IL7 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL7_HUMAN, P13232
Function: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is
important for proliferation during certain stages of B-cell maturation

     Genatlas biochemistry entry for IL7:
interleukin 7,20.2kDa,stimulating the proliferation of lymphoid progenitor cells

     Summary:
During embryonic development, IL7 as signaling molecule
affects the following cells: B-cell Progenitor Cells in Peripheral Blood

IL7 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Natural killer-like cells from Blood

     Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0005126cytokine receptor binding ----
GO:0005139interleukin-7 receptor binding IEA--
GO:0005515protein binding IPI8266077
GO:0008083growth factor activity ISS--
     
IL7 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for IL7:
 Synthetic lethal with c-Myc af  Synthetic lethal with imatinib 

     4 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Il7):
 cellular  hematopoietic system  immune system  no phenotypic analysis 

IL7 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for IL7: Il7tm1Dnax Il7tm1Hms

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IL7 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL7

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL7 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL7 

miRNA
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hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y hsa-miR-3647-3p
SwitchGear 3'UTR luciferase reporter plasmidIL7 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for IL7
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL7

Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of IL7

Clone
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OriGene clones in human, mouse for IL7 (see all 6)
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 4): IL7 (NM_000880)
Sino Biological Human cDNA Clone for IL7
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL7
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL7
Sirion Biotech Customized lentivirus for stable overexpression of IL7 
                     Customized lentivirus expression plasmids for stable overexpression of IL7 

Cell Line
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GenScript Custom overexpressing Cell Line Services for IL7
Search LifeMap BioReagents cell lines for IL7
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL7


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IL7 About   (see all 15)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Signaling by Interleukins
Signaling by Interleukins0.50
Interleukin-7 signaling0.50
B-Cell Development0.50
IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types0.33
Cytokine Signaling in Immune system0.50
2PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Regulation of Innate Immune Cells0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
3TGF-Beta Pathway
TGF-Beta Pathway0.60
Regulation of eIF4 and p70S6K0.43
MAPK Family Pathway0.60
SOCS Pathway0.40
JAK-STAT Pathway0.57
4Akt Signaling
Akt Signaling0.60
Tec Kinases Signaling0.55
p38 Signaling0.60
5Rho Family GTPases
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 R&D Systems Pathways for IL7
    IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types
IL-7 Signaling Pathways

5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL7 (see all 25)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions
Tec Kinases Signaling


5/8        Reactome Pathways for IL7 (see all 8)
    Interleukin-7 signaling
Interleukin-7 signaling
Signaling by Interleukins
Cytokine Signaling in Immune system
Cytokine Signaling in Immune system


4         Kegg Pathways  (Kegg details for IL7):
    Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage


IL7 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL7

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/16 Interacting proteins for IL7 (P132321, 3 ENSP000002638514) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
InteractantInteraction Details
GeneCardExternal ID(s)
IL7RP168711, 3, ENSP000003061574EBI-80516,EBI-80490 I2D: score=5 STRING: ENSP00000306157
IL2RGP317851, 3EBI-80516,EBI-80475 I2D: score=5 
JAK1ENSP000003432044STRING: ENSP00000343204
JAK3ENSP000003916764STRING: ENSP00000391676
CSF2ENSP000002968714STRING: ENSP00000296871
About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002360T cell lineage commitment IEA--
GO:0006955immune response ----
GO:0006959humoral immune response TAS2643102
GO:0007267cell-cell signaling TAS2643102
GO:0008284positive regulation of cell proliferation TAS2643102

IL7 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL7 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL7

10/63 Novoseek inferred chemical compound relationships for IL7 gene (see all 63)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
rantes 61.2 54 16011532 (11), 12634395 (6), 14516451 (3), 19700197 (3) (see all 26)
tyrosine 44.3 46 7694866 (3), 1708885 (2), 12750561 (2), 7957877 (2) (see all 33)
alpha-galactosylceramide 42.5 14 11150537 (3), 10715513 (3), 10594688 (3), 15368282 (1)
methylcellulose 42.1 6 8172177 (1), 7566971 (1), 7686604 (1), 10210330 (1) (see all 5)
hemocyanin 35.7 7 9815643 (1), 9111580 (1), 7615008 (1), 9935194 (1) (see all 7)
ionomycin 34.8 3 16045733 (1), 1292630 (1)
thymidine 31.8 10 8397935 (2), 8152260 (1), 15921626 (1), 9024505 (1) (see all 8)
phosphatidylinositol 24.2 13 7522165 (2), 9614102 (1), 11739504 (1), 12354940 (1) (see all 7)
il 10 22.4 4 19064561 (1), 10995008 (1), 16943231 (1), 19473542 (1)
c-d4t 18.8 1 12470268 (1)

Search CenterWatch for drugs/clinical trials and news about IL7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL7 gene (4 alternative transcripts): 
NM_000880.3  NM_001199886.1  NM_001199887.1  NM_001199888.1  

Unigene Cluster for IL7:

Interleukin 7
Hs.591873  [show with all ESTs]
Unigene Representative Sequence: BC047698
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000523959 ENST00000519833 ENST00000263851(uc003ybg.3 uc022awh.1 uc022awi.1 uc022awj.1 uc003ybh.3)
ENST00000518982(uc003ybi.3) ENST00000520269 ENST00000520215 ENST00000520317
ENST00000521323 ENST00000541183 ENST00000379113
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL7
8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate IL7 (see all 14):
hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y hsa-miR-3647-3p
SwitchGear 3'UTR luciferase reporter plasmidIL7 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL7
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL7
Clone
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GenScript: all cDNA clones in your preferred vector (see all 4): IL7 (NM_000880)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL7
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL7
Sirion Biotech Customized lentivirus for stable overexpression of IL7 
                     Customized lentivirus expression plasmids for stable overexpression of IL7 
Primer
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OriGene qPCR primer pairs and template standards for IL7
OriGene qSTAR qPCR primer pairs in human, mouse for IL7
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL7
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL7

Additional mRNA sequence: 

AB102879.1 AB102882.1 AB102883.1 AB102885.1 AB102893.1 AK226000.1 AK291538.1 BC032487.1 
BC047698.1 GQ919059.1 J04156.1 

8 DOTS entries:

DT.453043  DT.101982641  DT.120632347  DT.120632372  DT.120632362  DT.100745646  DT.120632339  DT.305914 

24/33 AceView cDNA sequences (see all 33):

BX105178 AI797222 NM_000880 CD013921 CD013919 BX107087 CD013920 CD013922 
AA683422 CD013923 BC047698 J04156 BM978895 BI869380 BI520517 BP367761 
BI912381 AA626244 AI688740 AI539460 BX508877 CB961906 BC032487 BM919542 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for IL7    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1:                                      -                                 
SP2:                                -     -                                 
SP3:                                      -           -     -               
SP4:                                                                        


ECgene alternative splicing isoforms for IL7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL7 expression in normal human tissues (normalized intensities)      IL7 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAAGAAATTG
IL7 Expression
About this image


IL7 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Ovary (Reproductive System)
         oocyte   
 
 Adipose (Muscoskeletal System)
         Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
 
 Epiblast (Early Embryonic Tissues)
         Epiblast Stem Cell line 7

See IL7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL7

SOURCE GeneReport for Unigene cluster: Hs.591873
    SABiosciences Expression via Pathway-Focused PCR Arrays including IL7 (see all 11): 
          Growth Factors in human mouse rat
          Interferons & Receptors in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat
          T-cell & B-cell Activation in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL7
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL7

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL7 gene from 2/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il71 , 5 interleukin 71, 5 80.61(n)1
69.93(a)1
  3 (2.02 cM)5
161961  NM_008371.41  NP_032397.11 
 75720775 
chicken
(Gallus gallus)
Aves IL76
interleukin 7 precursor
28(a)
1 ↔ 1
2(120078298-120084550)


ENSEMBL Gene Tree for IL7 (if available)
TreeFam Gene Tree for IL7 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1295 SNPs in IL7 are shown (see all 1295)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1408168541,2
--79644562(+) ATCGCA/CCCAGT 4 -- ds50010--------
rs1884729331,2
C--79644563(+) TCGCAC/TCAGTG 4 -- ds50010--------
rs1501450791,2
--79644574(+) AAGGTG/TAAATG 4 -- ds50010--------
rs801057421,2
F--79644649(+) CCAGAG/ACATCT 4 -- ds50011Minor allele frequency- A:0.10WA 118
rs119860571,2
C,H--79644680(+) CATCAG/TCACAT 4 -- ds50014Minor allele frequency- T:0.00NS EA 420
rs1920053741,2
--79644739(+) GCAATA/GCAAAC 4 -- ds50010--------
rs1158264661,2
C,F--79644860(+) TTTAAC/TATAGA 4 -- ds50011Minor allele frequency- T:0.03WA 118
rs25837591,2
C,F,A,H--79644964(+) TCTCAT/CCTTAA 4 -- ds500120Minor allele frequency- C:0.23NS EA NA WA 2340
rs1388876321,2
--79645102(+) TATAGA/TGTCAA 4 -- ut310--------
rs1831882921,2
--79645153(+) TATTAG/TTATCT 4 -- ut310--------

HapMap Linkage Disequilibrium report for IL7 (79587978 - 79717758 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for IL7:    About this table     
Variant IDTypeSubtypePubMed ID
nsv891059CNV Loss21882294
essv4456CNV CNV17122850


Human Gene Mutation Database (HGMD): IL7
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IL7
DNA2.0 Custom Variant and Variant Library Synthesis for IL7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 146660    OMIM disorders: --

20/126 diseases for IL7 (see all 126):    About MalaCards
t-lymphocytopenia    natural killer cell leukemia    lymphocytic choriomeningitis    lymphopenia
relapsing polychondritis    gamma chain deficiency    thyroid lymphoma    pancreas adenocarcinoma
interleukin-7 receptor alpha deficiency    castleman's disease    radiculopathy    severe combined immunodeficiency
osteoporosis, postmenopausal    acute pyelonephritis    mycosis fungoides    pyelonephritis
schistosomiasis    retinopathy of prematurity    lymphoblastic leukemia    acute lymphoblastic leukemia

3 diseases from the University of Copenhagen DISEASES database for IL7:
Lymphopenia     Leukemia     Human immunodeficiency virus infectious disease

IL7 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

10/97 Novoseek inferred disease relationships for IL7 gene (see all 97)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
severe combined immunodeficiency, x-linked 86.8 36 8026467 (1), 8605322 (1), 14966353 (1), 7481768 (1) (see all 24)
lymphopenia 66.3 39 15642146 (3), 10837414 (1), 16313348 (1), 16461915 (1) (see all 24)
lymphoblastic leukemia acute 61.2 34 7535143 (2), 2189505 (2), 7596167 (2), 2388482 (2) (see all 20)
necrosis 58.1 144 8943702 (4), 10438843 (2), 17448250 (2), 17185327 (2) (see all 99)
severe combined immunodeficiency 56.5 6 15661025 (1), 7777571 (1), 12411295 (1), 8916956 (1) (see all 5)
t-all 55.2 42 14607751 (5), 16019476 (4), 10891465 (4), 17296584 (3) (see all 14)
leukemia 51.8 47 15949292 (3), 1996110 (2), 10210778 (2), 1921447 (2) (see all 32)
hiv infections 50 50 19372891 (3), 12847229 (3), 11590518 (3), 9562375 (2) (see all 28)
tumors 45.3 202 1617669 (4), 8943702 (4), 7856736 (3), 8894249 (3) (see all 99)
immunodeficiency 45.3 43 15629410 (2), 15141001 (2), 19864382 (2), 17855550 (2) (see all 27)

Genetic Association Database (GAD): IL7
Human Genome Epidemiology (HuGE) Navigator: IL7 (14 documents)

Export disorders for IL7 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IL7 gene, integrated from 9 sources (see all 1298):
(articles sorted by number of sources associating them with IL7)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. (PubMed id 19141282)1, 2, 9 McElroy C.A....Walsh S.T. (2009)
  2. Genetic association analysis of the interleukin 7 gene (IL7) in multiple sclerosis. (PubMed id 17913246)1, 4, 9 Lundmark F....Hillert J. (2007)
  3. Comparative model building of interleukin-7 using interleukin-4 as a template: a structural hypothesis that displays atypical surface chemistry in helix D important for receptor activation. (PubMed id 10850801)1, 2, 9 Cosenza L.... Smith T.F. (2000)
  4. Disulfide bond assignment in human interleukin-7 by matrix-assisted laser desorption/ionization mass spectroscopy and site-directed cysteine to serine mutational analysis. (PubMed id 9407080)1, 2, 9 Cosenza L.... Murphy J.R. (1997)
  5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  6. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
  7. An application of Random Forests to a genome-wide ass ociation dataset: methodological considerations & new findings. (PubMed id 20546594)1, 4 Goldstein B.A....Barcellos L.F. (2010)
  8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
  9. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
  10. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3574 HGNC: 6023 AceView: IL7 Ensembl:ENSG00000104432 euGenes: HUgn3574
ECgene: IL7 Kegg: 3574 H-InvDB: IL7

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IL7 Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/Interleukin_7

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IL7 gene:
Search GeneIP for patents involving IL7

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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