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Aliases for IL7 Gene

Aliases for IL7 Gene

  • Interleukin 7 2 3 5
  • IL-7 3 4
  • Interleukin-7 3

External Ids for IL7 Gene

Previous GeneCards Identifiers for IL7 Gene

  • GC08M079682
  • GC08M079311
  • GC08M079694
  • GC08M079807
  • GC08M075134
  • GC08M079587

Summaries for IL7 Gene

Entrez Gene Summary for IL7 Gene

  • The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]

GeneCards Summary for IL7 Gene

IL7 (Interleukin 7) is a Protein Coding gene. Diseases associated with IL7 include Lymphopenia and Thyroid Lymphoma. Among its related pathways are PEDF Induced Signaling and Innate Immune System. GO annotations related to this gene include cytokine activity and cytokine receptor binding.

UniProtKB/Swiss-Prot for IL7 Gene

  • Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

Gene Wiki entry for IL7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL7 Gene

Genomics for IL7 Gene

Regulatory Elements for IL7 Gene

Enhancers for IL7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G079792 1.7 FANTOM5 Ensembl ENCODE 10.5 -988.9 -988856 3.0 FOXA2 ATF1 ARNT ZNF133 TCF12 GATA2 FOS DEK JUNB NCOA1 IL7 LOC101927040 LINC01607 HEY1 GC08M079801
GH08G078508 1.1 Ensembl ENCODE dbSUPER 10 +297.2 297233 0.4 JUND FOXA2 CREB1 FOS RELB EP300 ZC2HC1A IL7 PKIA GC08M078438
GH08G078849 0.6 FANTOM5 17.1 -44.5 -44544 0.3 MAFF MAFG BACH1 MLLT1 NFE2 EMSY MAFK IL7 GC08P078838 GC08P078869
GH08G079665 0.9 ENCODE 10.5 -861.9 -861946 3.3 ARID4B SIN3A FEZF1 GLIS2 ZNF263 SP3 CBX8 MXD3 GLIS1 WT1 IL7 LOC105375916 HEY1
GH08G078507 0.9 ENCODE dbSUPER 10 +297.7 297728 0.0 CTCF ZNF654 ZNF362 TRIM22 ZNF384 REST RAD21 SMC3 ZNF143 RELB ZC2HC1A IL7 PKIA GC08M078438
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL7 on UCSC Golden Path with GeneCards custom track

Promoters for IL7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000226134 723 2001 WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF48 YY1 GLIS2 ZNF143 ZNF207

Genomic Location for IL7 Gene

78,675,743 bp from pter
78,805,523 bp from pter
129,781 bases
Minus strand

Genomic View for IL7 Gene

Genes around IL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL7 Gene

Proteins for IL7 Gene

  • Protein details for IL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0N0L3
    • Q5FBY5
    • Q5FBY9

    Protein attributes for IL7 Gene

    177 amino acids
    Molecular mass:
    20187 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL7 Gene

    Alternative splice isoforms for IL7 Gene


neXtProt entry for IL7 Gene

Post-translational modifications for IL7 Gene

  • Glycosylation at posLast=9595, posLast=116116, and isoforms=2, 3141

Antibody Products

  • Abcam antibodies for IL7

Assay Products

  • Cloud-Clone Corp Assay Kits for IL7

No data available for DME Specific Peptides for IL7 Gene

Domains & Families for IL7 Gene

Gene Families for IL7 Gene

Protein Domains for IL7 Gene

Suggested Antigen Peptide Sequences for IL7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IL-7/IL-9 family.
  • Belongs to the IL-7/IL-9 family.
genes like me logo Genes that share domains with IL7: view

Function for IL7 Gene

Molecular function for IL7 Gene

GENATLAS Biochemistry:
interleukin 7,20.2kDa,stimulating the proliferation of lymphoid progenitor cells
UniProtKB/Swiss-Prot Function:
Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

LifeMap Function Summary for IL7 Gene

It affects the following cells:
IL7 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for IL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005126 cytokine receptor binding IEA --
GO:0005139 interleukin-7 receptor binding IEA --
GO:0005515 protein binding IPI 8266077
GO:0008083 growth factor activity IEA,ISS --
genes like me logo Genes that share ontologies with IL7: view
genes like me logo Genes that share phenotypes with IL7: view

Animal Models for IL7 Gene

MGI Knock Outs for IL7:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IL7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL7 Gene

Localization for IL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL7 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL7 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL7: view

Pathways & Interactions for IL7 Gene

genes like me logo Genes that share pathways with IL7: view

SIGNOR curated interactions for IL7 Gene


Gene Ontology (GO) - Biological Process for IL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002360 T cell lineage commitment IEA --
GO:0006955 immune response IEA --
GO:0006959 humoral immune response TAS 2643102
GO:0007267 cell-cell signaling TAS 2643102
GO:0008284 positive regulation of cell proliferation TAS 2643102
genes like me logo Genes that share ontologies with IL7: view

Drugs & Compounds for IL7 Gene

(35) Drugs for IL7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(28) Additional Compounds for IL7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL7: view

Transcripts for IL7 Gene

Unigene Clusters for IL7 Gene

Interleukin 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IL7

Alternative Splicing Database (ASD) splice patterns (SP) for IL7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2: - -
SP3: - - -

Relevant External Links for IL7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of IL7 Gene:


SOURCE GeneReport for Unigene cluster for IL7 Gene:


Evidence on tissue expression from TISSUES for IL7 Gene

  • Pancreas(4.2)
  • Blood(3.3)
  • Spleen(2.9)
  • Bone marrow(2.8)
  • Lymph node(2.8)
  • Intestine(2.3)
  • Skin(2.3)
  • Liver(2)
genes like me logo Genes that share expression patterns with IL7: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL7 Gene

Orthologs for IL7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL7 34 35
  • 99.81 (n)
(Bos Taurus)
Mammalia IL7 34 35
  • 84.85 (n)
(Canis familiaris)
Mammalia IL7 34 35
  • 84.39 (n)
(Mus musculus)
Mammalia Il7 34 16 35
  • 80.83 (n)
(Rattus norvegicus)
Mammalia Il7 34
  • 80 (n)
(Monodelphis domestica)
Mammalia IL7 35
  • 34 (a)
Species where no ortholog for IL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL7 Gene

Gene Tree for IL7 (if available)
Gene Tree for IL7 (if available)

Paralogs for IL7 Gene

No data available for Paralogs for IL7 Gene

Variants for IL7 Gene

Sequence variations from dbSNP and Humsavar for IL7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000012710 -- 78,756,268(+) CTTGT(A/T)GTTTT intron-variant
rs1000052177 -- 78,752,480(+) GATAG(C/T)TCATT intron-variant
rs1000059242 -- 78,731,556(+) TAGCA(C/T)TGACA intron-variant, downstream-variant-500B
rs1000080875 -- 78,756,245(+) TGTTG(A/C)GAAAC intron-variant
rs1000095322 -- 78,709,981(+) GTAAG(C/G/T)CACAC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IL7 Gene

Variant ID Type Subtype PubMed ID
dgv3851n106 CNV deletion 24896259
esv2759622 CNV loss 17122850
nsv1026069 CNV gain 25217958
nsv611577 CNV gain 21841781
nsv971670 CNV duplication 23825009

Variation tolerance for IL7 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL7 Gene

Disorders for IL7 Gene

MalaCards: The human disease database

(24) MalaCards diseases for IL7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • lymphocytopenia
thyroid lymphoma
severe combined immunodeficiency, x-linked
  • gamma chain deficiency
cyclic thrombocytopenia
  • thrombocytopenia cyclic
interleukin-7 receptor alpha deficiency
  • il-7r
- elite association - COSMIC cancer census association via MalaCards
Search IL7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IL7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL7 Gene

Publications for IL7 Gene

  1. Disulfide bond assignment in human interleukin-7 by matrix-assisted laser desorption/ionization mass spectroscopy and site-directed cysteine to serine mutational analysis. (PMID: 9407080) Cosenza L. … Murphy J.R. (J. Biol. Chem. 1997) 3 4 22 64
  2. Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway. (PMID: 19864382) Juffroy O. … Chakrabarti L.A. (J. Virol. 2010) 3 22 64
  3. Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response. (PMID: 20167604) Rose T. … ThA"ze J. (J. Biol. Chem. 2010) 3 22 64
  4. IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells. (PMID: 20190194) Henriques C.M. … Barata J.T. (Blood 2010) 3 22 64
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A. … Janssen R. (Pediatr. Pulmonol. 2010) 3 46 64

Products for IL7 Gene

  • Addgene plasmids for IL7

Sources for IL7 Gene

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