Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL7 Gene

protein-coding GIFtS: 63
GCID: GC08M079587

interleukin 7

Explore 132 diseases affiliated with
IL7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 7¹ ²
IL-7¹ ² ³
Interleukin-7¹

External Ids:	HGNC: 6023¹	Entrez Gene: 3574²	Ensembl: ENSG00000104432⁷	OMIM: 146660⁵	UniProtKB: P13232³

Export aliases for IL7 gene to outside databases

Previous GC identifers: GC08M078689 GC08M079682 GC08M079311 GC08M079694 GC08M079807 GC08M075134

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL7:

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte

growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is

found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development.

This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a

regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an

essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding

distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been

confirmed.(provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: IL7_HUMAN, P13232

Function: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important

for proliferation during certain stages of B-cell maturation

Gene Wiki entry for IL7 (Interleukin 7)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008183.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL7 gene promoter:
STAT1 p53 GATA-3 AP-1 ATF-2 Evi-1 IRF-7A FOXO1a c-Jun FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL7 promoter sequence

Search SABiosciences Chromatin IP Primers for IL7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12-q13 Ensembl cytogenetic band: 8q21.12 HGNC cytogenetic band: 8q12-q13

IL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL7 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M079587: view genomic region (about GC identifiers)

Start:	79,587,978 bp from pter	End:	79,717,758 bp from pter
Size:	129,781 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL7_HUMAN, P13232 (See protein sequence)

Recommended Name: Interleukin-7 precursor

Size: 177 amino acids; 20187 Da

Subcellular location: Secreted

3 PDB 3D structures from and Proteopedia for IL7:

1IL7 (3D)

3DI2 (3D)

3DI3 (3D)

Secondary accessions: A0N0L3 Q5FBY9

Alternative splicing: 2 isoforms: P13232-1 P13232-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL7: NX_P13232

IL7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_000871.1 NP_001186815.1 NP_001186816.1 NP_001186817.1

ENSEMBL proteins:

ENSP00000263851 ENSP00000430272 ENSP00000427750 ENSP00000428364 ENSP00000427800

ENSP00000438922 ENSP00000368408

Reactome Protein details: P13232
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant IL7 Protein
	R&D Systems Recombinant & Natural Proteins for IL7 (IL-7)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: IL7 OriGene Custom Protein Services for IL7
	GenScript Purified and Recombinant Proteins for IL7
	Novus Biologicals IL7 Proteins Novus Biologicals IL7 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IL7
	Uscn Proteins for IL7

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

IL7 for ontologies About GeneDecksing

IL7 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for IL7 (IL-7)
	OriGene Antibodies: IL7 OriGene Custom Antibody Services for IL7
	GenScript Custom Superior Antibodies Services for IL7
	Novus Biologicals IL7 Antibodies
	Abcam antibodies for IL7
	Uscn Antibodies for IL7
	ThermoFisher Antibodies for IL7

Assay Products for IL7:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for IL7 (IL-7) (see all)
	GenScript Custom Assay Services for IL7
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IL7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL7 for domains About GeneDecksing

3 InterPro domains/families:

IPR000226 Interleukin_7_9

IPR018049 Interleukin-7/-9_CS

IPR001181 Interleukin-7

Graphical View of Domain Structure for InterPro Entry P13232

ProtoNet protein and cluster: P13232

2 Blocks protein families:

IPB000226 Interleukin-7/interleukin-9

IPB001181 Interleukin-7

UniProtKB/Swiss-Prot: IL7_HUMAN, P13232

Similarity: Belongs to the IL-7/IL-9 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IL7_HUMAN, P13232

Function: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important

for proliferation during certain stages of B-cell maturation

Genatlas biochemistry entry for IL7:

interleukin 7,20.2kDa,stimulating the proliferation of lymphoid progenitor cells

Summary:

During embryonic development, IL7 as signaling molecule

affects the following cells: B-cell Progenitor Cells in Peripheral Blood

IL7 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Natural killer-like cells

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL7
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate IL7 (see all 14):
		hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y hsa-miR-3647-3p

		SwitchGear 3'UTR luciferase reporter plasmid: IL7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL7 (see all 7) OriGene shRNA RFP: IL7 OriGene siRNA: IL7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL7

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL7 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): IL7 (NM_000880)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL7
		Search LifeMap BioReagents cell lines for IL7

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL7

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005126	cytokine receptor binding	--	--
GO:0005139	interleukin-7 receptor binding	IEA	--
GO:0005515	protein binding	IPI	8266077
GO:0008083	growth factor activity	ISS	--

IL7 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for IL7:

Synthetic lethal with c-Myc af

Synthetic lethal with imatinib

Animal Models:
Mouse knock-outs for IL7: Il7^tm1Dnax Il7^tm1Hms
4 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Il7):

cellular

hematopoietic system

immune system

no phenotypic analysis

IL7 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	Regulation of eIF4 and p70S6K	0.43
MAPK Family Pathway	0.60	SOCS Pathway	0.29
JAK-STAT Pathway	0.57

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

B-Cell Development

B-Cell Development

1.00

IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

2 R&D Systems Pathways for IL7

	IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types
	IL-7 Signaling Pathways

5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL7 (see all 25)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	Tec Kinases Signaling

5 Reactome Pathways for IL7

	Interleukin-7 signaling
	Cytokine Signaling in Immune system
	Immune System
	Signaling by Interleukins
	Immune System

3 Kegg Pathways (Kegg details for IL7):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	Hematopoietic cell lineage

IL7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL7

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/16 Interacting proteins for IL7 (P13232^{1, 3} ENSP00000263851⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL7R	P16871¹^,³, ENSP00000306157⁴	EBI-80516,EBI-80490 I2D: score=5 STRING: ENSP00000306157
IL2RG	P31785¹^,³	EBI-80516,EBI-80475 I2D: score=5
JAK1	ENSP00000343204⁴	STRING: ENSP00000343204
JAK3	ENSP00000391676⁴	STRING: ENSP00000391676
CSF2	ENSP00000296871⁴	STRING: ENSP00000296871

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002360	T cell lineage commitment	IEA	--
GO:0006955	immune response	--	--
GO:0006959	humoral immune response	TAS	2643102
GO:0007267	cell-cell signaling	TAS	2643102
GO:0008284	positive regulation of cell proliferation	TAS	2643102

IL7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL7
10/63 Novoseek chemical compound relationships for IL7 gene (see all 63) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	61.2	54	16011532 (11), 12634395 (6), 14516451 (3), 19700197 (3) (see all 26)
tyrosine	44.3	46	7694866 (3), 1708885 (2), 12750561 (2), 7957877 (2) (see all 33)
alpha-galactosylceramide	42.5	14	11150537 (3), 10715513 (3), 10594688 (3), 15368282 (1)
methylcellulose	42.1	6	8172177 (1), 7566971 (1), 7686604 (1), 10210330 (1) (see all 5)
hemocyanin	35.7	7	9815643 (1), 9111580 (1), 7615008 (1), 9935194 (1) (see all 7)
ionomycin	34.8	3	16045733 (1), 1292630 (1)
thymidine	31.8	10	8397935 (2), 8152260 (1), 15921626 (1), 9024505 (1) (see all 8)
phosphatidylinositol	24.2	13	7522165 (2), 9614102 (1), 11739504 (1), 12354940 (1) (see all 7)
il 10	22.4	4	19064561 (1), 10995008 (1), 16943231 (1), 19473542 (1)
c-d4t	18.8	1	12470268 (1)

Search CenterWatch for drugs/clinical trials and news about IL7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL7 gene (4 alternative transcripts):

NM_000880.3 NM_001199886.1 NM_001199887.1 NM_001199888.1

Unigene Cluster for IL7:

Interleukin 7

Hs.591873 [show with all ESTs]

Unigene Representative Sequence: BC047698

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000523959 ENST00000519833 ENST00000263851(uc003ybg.3 uc022awh.1 uc022awi.1 uc022awj.1 uc003ybh.3)

ENST00000518982(uc003ybi.3) ENST00000520269 ENST00000520215 ENST00000520317

ENST00000521323 ENST00000541183 ENST00000379113

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL7
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate IL7 (see all 14):
		hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y hsa-miR-3647-3p

		SwitchGear 3'UTR luciferase reporter plasmid: IL7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL7 (see all 7) OriGene shRNA RFP: IL7 OriGene siRNA: IL7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL7

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL7 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): IL7 (NM_000880)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL7

Additional cDNA sequence:

AB102879.1 AB102882.1 AB102883.1 AB102885.1 AB102893.1 AK226000.1 AK291538.1 BC032487.1

BC047698.1 GQ919059.1 J04156.1

7 DOTS entries:

DT.453043 DT.101982641 DT.120632347 DT.120632372 DT.120632362 DT.100745646 DT.305914

24/33 AceView cDNA sequences (see all 33):

J04156 CD013919 BC047698 BX105178 AA683422 BM978895 NM_000880 AI797222

CD013923 CD013922 CD013921 BX107087 CD013920 BI869380 BI520517 BU632596

BM919542 CB961906 AI539460 AA626244 BI912381 BX508877 AI688740 BP367761

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for IL7 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6
SP1:													-
SP2:											-		-
SP3:													-				-		-
SP4:

ECgene alternative splicing isoforms for IL7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGAAATTG

About this image

IL7 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

See IL7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL7

SOURCE GeneReport for Unigene cluster: Hs.591873

SABiosciences Expression via Pathway-Focused PCR Arrays including IL7 (see all 11):

Growth Factors in human mouse rat

Interferons & Receptors in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

T-cell & B-cell Activation in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL7 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il7^{1 , 5}	interleukin 7^{1, 5}	80.61(n)¹ 69.93(a)¹		3 (2.02 cM)⁵ 16196¹ NM_008371.4¹ NP_032397.1¹ 7572077⁵
chicken (Gallus gallus)	Aves	IL7⁶	hypothetical protein LOC420193	30(a)	1 ↔ 1	2(125117020-125123272)

ENSEMBL Gene Tree for IL7 (if available)
TreeFam Gene Tree for IL7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140816854^1,2		--	79644562(+)	`ATCGCA/CCCAGT`	4	--	ds500¹		0	--	--	--	--
rs188472933^1,2		--	79644563(+)	`TCGCAC/TCAGTG`	4	--	ds500¹		0	--	--	--	--
rs150145079^1,2		--	79644574(+)	`AAGGTG/TAAATG`	4	--	ds500¹		0	--	--	--	--
rs80105742^1,2	F,	--	79644649(+)	`CCAGAG/ACATCT`	4	--	ds500¹		1		WA	118
rs11986057^1,2	C,H	--	79644680(+)	`CATCAG/TCACAT`	4	--	ds500¹		4		NS EA	420
rs192005374^1,2		--	79644739(+)	`GCAATA/GCAAAC`	4	--	ds500¹		0	--	--	--	--
rs115826466^1,2	F,	--	79644860(+)	`TTTAAC/TATAGA`	4	--	ds500¹		1		WA	118
rs2583759^1,2	C,F,A,H,	--	79644964(+)	`TCTCAT/CCTTAA`	4	--	ds500¹		20		NS EA NA WA	2340
rs138887632^1,2		--	79645102(+)	`TATAGA/TGTCAA`	4	--	ut3¹		0	--	--	--	--
rs183188292^1,2		--	79645153(+)	`TATTAG/TTATCT`	4	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IL7 (79587978 - 79717758 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for IL7
2 CNVs: 3737 95522
1 Indel: 82655
Human Gene Mutation Database (HGMD): IL7

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL7

DNA2.0 Custom Variant and Variant Library Synthesis for IL7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL7 for disorders           About GeneDecksing

OMIM gene information: 146660    OMIM disorders: --

20/132 diseases for IL7 (see all 132):    About MalaCards

interleukin-7 receptor alpha deficiency pre-b-cell acute lymphoblastic leukemia graft versus host disease severe combined immunodeficiency

natural killer cell leukemia gamma chain deficiency hypersensitivity reaction type ii disease human immunodeficiency virus infectious disease

osteoporosis, postmenopausal mycosis fungoides lymphocytic choriomeningitis combined immunodeficiency

relapsing polychondritis common variable immunodeficiency acute lymphoblastic leukemia lymphoblastic leukemia

major depressive disorder fibrous histiocytoma bullous pemphigoid digeorge syndrome

5 diseases from the University of Copenhagen DISEASES database for IL7:

Lymphopenia Severe combined immunodeficiency Human immunodeficiency virus infectious disease Leukemia

Lymphoma

10/97 Novoseek disease relationships for IL7 gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
severe combined immunodeficiency, x-linked	86.8	36	8026467 (1), 8605322 (1), 14966353 (1), 7481768 (1) (see all 24)
lymphopenia	66.3	39	15642146 (3), 10837414 (1), 16313348 (1), 16461915 (1) (see all 24)
lymphoblastic leukemia acute	61.2	34	7535143 (2), 2189505 (2), 7596167 (2), 2388482 (2) (see all 20)
necrosis	58.1	144	8943702 (4), 10438843 (2), 17448250 (2), 17185327 (2) (see all 99)
severe combined immunodeficiency	56.5	6	15661025 (1), 7777571 (1), 12411295 (1), 8916956 (1) (see all 5)
t-all	55.2	42	14607751 (5), 16019476 (4), 10891465 (4), 17296584 (3) (see all 14)
leukemia	51.8	47	15949292 (3), 1996110 (2), 10210778 (2), 1921447 (2) (see all 32)
hiv infections	50	50	19372891 (3), 12847229 (3), 11590518 (3), 9562375 (2) (see all 28)
tumors	45.3	202	1617669 (4), 8943702 (4), 7856736 (3), 8894249 (3) (see all 99)
immunodeficiency	45.3	43	15629410 (2), 15141001 (2), 19864382 (2), 17855550 (2) (see all 27)

Human Genome Epidemiology (HuGE) Navigator: IL7 (14 documents)

Export disorders for IL7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL7 gene, integrated from 9 sources (see all 1282):
(articles sorted by number of sources associating them with IL7)

Utopia: connect your pdf to the dynamic
world of online information

Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. (PubMed id 19141282)^{1, 2, 9} McElroy C.A....Walsh S.T. (2009)
Comparative model building of interleukin-7 using interleukin-4 as a template: a structural hypothesis that displays atypical surface chemistry in helix D important for receptor activation. (PubMed id 10850801)^{1, 2, 9} Cosenza L.... Smith T.F. (2000)
Disulfide bond assignment in human interleukin-7 by matrix-assisted laser desorption/ionization mass spectroscopy and site-directed cysteine to serine mutational analysis. (PubMed id 9407080)^{1, 2, 9} Cosenza L.... Murphy J.R. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prediction of the three-dimensional structure of human interleukin-7 by homology modeling. (PubMed id 8862549)^{1, 2} Kroemer R.T.... Richards W.G. (1996)
Characterization of the human and murine IL-7 genes. (PubMed id 2329282)^{1, 2} Lupton S.D.... Goodwin R.G. (1990)
Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. (PubMed id 2643102)^{1, 2} Goodwin R.G.... Namen A.E. (1989)
A three-base-deletion polymorphism in the upstream non-coding region of human interleukin 7 (IL-7) gene could enhance levels of IL-7 expression. (PubMed id 17373935)^{1, 9} Song H....Shioda T. (2007)
IL-7 up-regulates TNF-alpha-dependent osteoclastogenesis in patients affected by solid tumor. (PubMed id 17205128)^{1, 9} Roato I....Ferracini R. (2006)
Biological and clinical implications of interleukin-7 and lymphopoiesis. (PubMed id 10390077)^{1, 9} Appasamy P.M. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3574	HGNC: 6023	AceView: IL7	Ensembl:ENSG00000104432	euGenes: HUgn3574
ECgene: IL7	Kegg: 3574	H-InvDB: IL7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL7	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_7

Intellectual Property for IL7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IL7 gene:
Search GeneIP for patents involving IL7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Kits and Assays available from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Small Molecules at EMD Millipore
	EMD Millipore Purified and/or Recombinant IL7 Protein
	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for IL7 (IL-7)		Browse Cell Culture Products
	ELISAs for IL7 (IL-7)		Flow Cytometry Kits for IL7 (IL-7)
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for IL7 (IL-7)

	OriGene Antibodies for IL7		OriGene shRNA RFP for IL7
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL7		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL7
	OriGene Protein Over-expression Lysate for IL7		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for IL7		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL7		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL7
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for IL7		OriGene Custom Protein Services for IL7
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL7
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL7
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL7
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL7
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL7
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL7

	GenScript Purified and Recombinant Proteins for IL7		GenScript cDNA clones with any tag delivered in your preferred vector for IL7
	GenScript Custom Assay Services for IL7		GenScript Custom Superior Antibodies Services for IL7
	GenScript Custom overexpressing Cell Line Services for IL7		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in IL7 promoter
	Search Chromatin IP Primers for IL7
	RT² qPCR Primer Assay in human, mouse, rat IL7
	GNC Network for IL7
	SABiosciences PCR Arrays including human, mouse, rat IL7

Search Tocris compounds for IL7

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	IL7 antibodies
	IL7 proteins
	IL7 lysates

	Antibodies for IL7
	See all of Abcam's Antibodies, Kits and Proteins for IL7
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for IL7

IL7 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for IL7

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL7

	SwitchGear 3'UTR luciferase reporter plasmids for IL7
	SwitchGear Promoter luciferase reporter plasmids for IL7

ThermoFisher Antibodies for IL7

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL7

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes IL7 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

IL7 Gene

interleukin 7

Aliases
for IL7 gene

Summaries
for IL7 gene

Genomic Views
for IL7 gene

Proteins
for IL7 gene

Protein Domains /
Families
for IL7 gene

Function
for IL7 gene

Pathways & Interactions
for IL7 gene

Drugs & Compounds
for IL7 gene

Transcripts
for IL7 gene

Expression
for IL7 gene

Orthologs
for IL7 gene

Paralogs
for IL7 gene

Genomic Variants
for IL7 gene

Disorders / Diseases
for IL7 gene

Publications
for IL7 gene

External Searches for IL7 gene

Genome Databases showing IL7 gene

Other Databases showing IL7 gene

Specialized Databases showing IL7 gene

Intellectual Property
for IL7 gene

Products
for IL7 gene

View Random Gene

Osteopetrosis
Leukemia B-Cell
Lymphoblastic Leukemia Acute Childhood
Herpes Simplex
immunopathology
T-cell childhood acute lymphoblastic leukemia
Lymphoma T-Cell
Sclerosis
Thymoma
Colitis Ulcerative
COLON CARCINOMA
Lymphoma AIDS-Related
Atherosclerosis
Skin Diseases
Breast Cancer
DiGeorge Syndrome
NSCLC
Asthma
AIDS
Mycosis Fungoides
Cancer
Thrombocytopenia
Lymphoma
bone loss
Pathological Processes
Shock
effusion
Osteolysis
Multiple Sclerosis
Inflammation
BONE LESION
Burkitt Lymphoma
Osteoporosis Postmenopausal
osteolytic
Tuberculosis
immunodeficiency
Neutropenia
Psoriasis
Cervical Cancer
MYELOMA
Lymphocytic Choriomeningitis
Rheumatoid Arthritis
prostate cancer
Tumors
Metastasis
Necrosis
Lymphoblastic Leukemia Acute
Autoimmunity
virus infection
Lymphoma T-Cell Cutaneous
Hepatitis C
progressive disease
Colitis
Pemphigoid Bullous
Autoimmune Diseases
Melanoma
BREAST CARCINOMA
Leukemia Lymphocytic Chronic
Hyperplasia
Tetanus
Hodgkin Disease
Carcinoma
Osteoarthritis
B-ALL
ACUTE LEUKEMIA
Leukemia
Infectious disease
Severe Combined Immunodeficiency
metastatic cancer
Opportunistic Infections
SEVERE COMBINED IMMUNODEFICIENCY, X-LINKED
metastatic melanoma
Lymphopenia
Carcinoma Renal Cell
Hematologic Malignancies
Viremia
Influenza
Schistosomiasis
Sezary Syndrome
Pleural Effusion Malignant
cytopenia
HIV Infections
T-ALL
OVARIAN CARCINOMA
Lymphocytic Leukemia Chronic B-Cell
Dengue
SKIN LESION
Atrophy
Graft-Versus-Host Disease
residual disease
EBV Infections
leukemogenesis
Lymphoma Non-Hodgkins
genetic disorder
BONE DESTRUCTION
Synovitis
LEUKAEMIA LYMPHOCYTIC

Advanced Search

Export list of displayed genes

IL7 Gene

interleukin 7

Aliasesfor IL7 gene

Summariesfor IL7 gene

Genomic Viewsfor IL7 gene

Proteinsfor IL7 gene

Protein Domains /Familiesfor IL7 gene

Functionfor IL7 gene

Pathways & Interactionsfor IL7 gene

Drugs & Compoundsfor IL7 gene

Transcriptsfor IL7 gene

Expression for IL7 gene

Orthologsfor IL7 gene

Paralogsfor IL7 gene

Genomic Variantsfor IL7 gene

Disorders / Diseasesfor IL7 gene

Publicationsfor IL7 gene

External Searches for IL7 gene

Genome Databases showing IL7 gene

Other Databases showing IL7 gene

Specialized Databases showing IL7 gene

Intellectual Propertyfor IL7 gene

Productsfor IL7 gene

View Random Gene

Aliases
for IL7 gene

Summaries
for IL7 gene

Genomic Views
for IL7 gene

Proteins
for IL7 gene

Protein Domains /
Families
for IL7 gene

Function
for IL7 gene

Pathways & Interactions
for IL7 gene

Drugs & Compounds
for IL7 gene

Transcripts
for IL7 gene

Expression
for IL7 gene

Orthologs
for IL7 gene

Paralogs
for IL7 gene

Genomic Variants
for IL7 gene

Disorders / Diseases
for IL7 gene

Publications
for IL7 gene

Intellectual Property
for IL7 gene

Products
for IL7 gene