Aliases for IL6ST Gene
Aliases for IL6ST Gene
External Ids for IL6ST Gene
- HGNC: 6021
- Entrez Gene: 3572
- Ensembl: ENSG00000134352
- OMIM: 600694
- UniProtKB: P40189
Previous GeneCards Identifiers for IL6ST Gene
- GC05M055398
- GC05M056665
- GC05M055207
- GC05M055252
- GC05M055272
- GC05M052204
- GC05M055230
Summaries for IL6ST Gene
-
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
GeneCards Summary for IL6ST Gene
IL6ST (Interleukin 6 Signal Transducer) is a Protein Coding gene. Diseases associated with IL6ST include Kaposi Sarcoma and Myeloma. Among its related pathways are Th17 Differentiation Pathway and Transcription Androgen Receptor nuclear signaling. GO annotations related to this gene include protein homodimerization activity and interleukin-6 receptor binding. An important paralog of this gene is CSF3R.
UniProtKB/Swiss-Prot for IL6ST Gene
-
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL6ST Gene
Genomics for IL6ST Gene
Regulatory Elements for IL6ST Gene
Enhancers for IL6ST Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around IL6ST on UCSC Golden Path with GeneCards custom track
Promoters for IL6ST Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around IL6ST on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the IL6ST gene promoter:
Regulatory Element Products
Genomic Location for IL6ST Gene
- Chromosome:
- 5
- Start:
- 55,935,095 bp from pter
- End:
- 55,994,993 bp from pter
- Size:
- 59,899 bases
- Orientation:
- Minus strand
Genomic View for IL6ST Gene
Genes around IL6ST on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q11.2 by Ensembl
- 5q11.2 by Entrez Gene
- 5q11.2 by HGNC
IL6ST Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL6ST Gene
Proteins for IL6ST Gene
-
Protein details for IL6ST Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P40189-IL6RB_HUMAN
- Recommended name:
- Interleukin-6 receptor subunit beta
- Protein Accession:
- P40189
- A0N0L4
- Q5FC04
- Q9UQ41
Protein attributes for IL6ST Gene
- Size:
- 918 amino acids
- Molecular mass:
- 103537 Da
- Quaternary structure:
-
- Component of a hexamer of two molecules each of IL6, IL6R and IL6ST (PubMed:12829785). Forms heterodimers composed of LIFR and IL6ST (type I OSM receptor) which are activated by LIF and OSM (PubMed:8999038). Also forms heterodimers composed of OSMR and IL6ST (type II receptor) which are activated by OSM but not by LIF (PubMed:8999038). Homodimer. The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6 (PubMed:11238858, PubMed:11251120). Interacts with HCK (PubMed:9406996). Interacts with INPP5D/SHIP1 (By similarity).
Three dimensional structures from OCA and Proteopedia for IL6ST Gene
Protein Expression for IL6ST Gene
Post-translational modifications for IL6ST Gene
- Heavily N-glycosylated (PubMed:11098061, PubMed:16335952, PubMed:19159218, PubMed:19139490, PubMed:11251120). Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding (PubMed:19915009).
- Phosphorylation of Ser-782 down-regulates cell surface expression.
- Glycosylation at Asn 43, Asn 83, Asn 131, Asn 157, Asn 227, Asn 379, Asn 383, Asn 390, Asn 553, and Asn 564
- Modification sites at PhosphoSitePlus
Other Protein References for IL6ST Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for IL6ST
- R&D Systems Antibodies for IL6ST (gp130)
- Cell Signaling Technology (CST) Antibodies for IL6ST (gp130)
- Novus Biologicals Antibodies for IL6ST
-
Cloud-Clone Corp. Antibodies for IL6ST
- Invitrogen Antibodies for IL6ST
- antibodies-online Antibodies for IL6ST: See all 159
- GeneTex IL6ST antibody for IL6ST
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL6ST
Protein Products
- R&D Systems Proteins and Enzymes for IL6ST (gp130)
-
OriGene Purified Proteins for IL6ST
- Search Origene for MassSpec and Protein Over-expression Lysates for IL6ST
- Origene Custom Protein Services for IL6ST
- Sino Biological Recombinant Proteins for IL6ST
- Sino Biological Cell Lysates for IL6ST
-
Cloud-Clone Corp. Proteins for IL6ST
- antibodies-online Proteins for IL6ST: See all 21
- Search antibodies-online for peptides
- Search GeneTex for Proteins for IL6ST
Assay Products
- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for IL6ST (gp130)
-
Cloud-Clone Corp Assay Kits for IL6ST
- antibodies-online Kits for IL6ST: See all 11
No data available for DME Specific Peptides for IL6ST Gene
Domains & Families for IL6ST Gene
Gene Families for IL6ST Gene
Protein Domains for IL6ST Gene
Suggested Antigen Peptide Sequences for IL6ST Gene
Graphical View of Domain Structure for InterPro Entry
P40189UniProtKB/Swiss-Prot:
IL6RB_HUMAN :- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- Belongs to the type I cytokine receptor family. Type 2 subfamily.
- Domain:
-
- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- The box 1 motif is required for JAK interaction and/or activation.
- Contains 5 fibronectin type-III domains.
- Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
- Family:
-
- Belongs to the type I cytokine receptor family. Type 2 subfamily.
Function for IL6ST Gene
Molecular function for IL6ST Gene
- GENATLAS Biochemistry:
- interleukin 6,signal transducer (GP130),needed for IL6R activity and signal transduction of the IL-6 related cytokines,mediated by JAK kinases,ubiquitously expressed,with a membrane bound and an alternatively spliced secreted form
- UniProtKB/Swiss-Prot Function:
- Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
- UniProtKB/Swiss-Prot Induction:
- LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004896 | cytokine receptor activity | IEA | -- |
| GO:0019981 | contributes_to interleukin-6 binding | IPI | 12829785 |
Phenotypes for IL6ST Gene
- MGI mutant phenotypes for IL6ST:
-
inferred from 11 alleles
- cellular phenotype
- mortality/aging
- behavior/neurological phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- liver/biliary system phenotype
- normal phenotype
- immune system phenotype
- cardiovascular system phenotype
- integument phenotype
- growth/size/body region phenotype
- hematopoietic system phenotype
- tumorigenesis
- homeostasis/metabolism phenotype
- digestive/alimentary phenotype
- embryo phenotype
- nervous system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for IL6ST:
Animal Models for IL6ST Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for IL6ST gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IL6ST gene
- Search ViGene Biosciences for IL6ST
CRISPR Products
-
OriGene CRISPR knockouts for IL6ST
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL6ST
- GenScript: Design CRISPR guide RNA sequences for IL6ST
miRNA for IL6ST Gene
- miRTarBase miRNAs that target IL6ST
-
- hsa-mir-590-3p (MIRT016213)
- hsa-mir-335-5p (MIRT017169)
- hsa-mir-215-5p (MIRT024434)
- hsa-mir-192-5p (MIRT026283)
- hsa-mir-615-3p (MIRT040397)
- hsa-mir-190a-3p (MIRT215958)
- hsa-mir-5011-5p (MIRT215961)
- hsa-mir-302c-3p (MIRT216008)
- hsa-mir-512-3p (MIRT216012)
- hsa-mir-4501 (MIRT216019)
- hsa-mir-25-3p (MIRT216029)
- hsa-mir-32-5p (MIRT216030)
- hsa-mir-92a-3p (MIRT216031)
- hsa-mir-363-3p (MIRT216033)
- hsa-mir-367-3p (MIRT216034)
- hsa-mir-92b-3p (MIRT216035)
- hsa-mir-4789-5p (MIRT216039)
- hsa-mir-6074 (MIRT216040)
- hsa-mir-4729 (MIRT216059)
- hsa-mir-4661-5p (MIRT216085)
- hsa-mir-559 (MIRT216093)
- hsa-mir-548b-5p (MIRT216094)
- hsa-mir-548a-5p (MIRT216095)
- hsa-mir-548c-5p (MIRT216096)
- hsa-mir-548d-5p (MIRT216098)
- hsa-mir-548j-5p (MIRT216100)
- hsa-mir-548h-5p (MIRT216101)
- hsa-mir-548i (MIRT216102)
- hsa-mir-548w (MIRT216103)
- hsa-mir-548y (MIRT216106)
- hsa-mir-548o-5p (MIRT216107)
- hsa-mir-548ab (MIRT216108)
- hsa-mir-548ad-5p (MIRT216109)
- hsa-mir-548ae-5p (MIRT216110)
- hsa-mir-548ak (MIRT216111)
- hsa-mir-548am-5p (MIRT216112)
- hsa-mir-548ap-5p (MIRT216113)
- hsa-mir-548aq-5p (MIRT216114)
- hsa-mir-548ar-5p (MIRT216115)
- hsa-mir-548as-5p (MIRT216116)
- hsa-mir-548au-5p (MIRT216117)
- hsa-mir-548ay-5p (MIRT216119)
- hsa-mir-548bb-5p (MIRT216120)
- hsa-mir-4650-3p (MIRT381714)
- hsa-mir-1303 (MIRT485468)
- hsa-mir-5589-3p (MIRT485469)
- hsa-mir-4272 (MIRT485470)
- hsa-mir-548p (MIRT485471)
- hsa-mir-3924 (MIRT493503)
- hsa-mir-4473 (MIRT493504)
- hsa-mir-6073 (MIRT493505)
- hsa-mir-4720-3p (MIRT493506)
- hsa-mir-4804-3p (MIRT493507)
- hsa-mir-4328 (MIRT493508)
- hsa-mir-7852-3p (MIRT493509)
- hsa-mir-6507-3p (MIRT493510)
- hsa-mir-8054 (MIRT493511)
- hsa-mir-548l (MIRT493512)
- hsa-mir-548k (MIRT493513)
- hsa-mir-548av-5p (MIRT493514)
- hsa-mir-223-3p (MIRT493515)
- hsa-mir-142-3p (MIRT493516)
- hsa-mir-520f-3p (MIRT493517)
- hsa-mir-1277-5p (MIRT511363)
- hsa-mir-6867-5p (MIRT511364)
- hsa-mir-223-5p (MIRT511365)
- hsa-mir-190b (MIRT511366)
- hsa-mir-190a-5p (MIRT511367)
- hsa-mir-511-3p (MIRT511368)
- hsa-mir-4766-3p (MIRT522996)
- hsa-mir-3941 (MIRT522997)
- hsa-mir-3908 (MIRT522998)
- hsa-mir-4703-5p (MIRT522999)
- hsa-mir-3942-5p (MIRT523000)
- hsa-mir-603 (MIRT523001)
- hsa-mir-362-3p (MIRT523002)
- hsa-mir-329-3p (MIRT523003)
- hsa-mir-8485 (MIRT523004)
- hsa-mir-5706 (MIRT536667)
- hsa-mir-4782-5p (MIRT536668)
- hsa-mir-516b-5p (MIRT536669)
- hsa-mir-488-5p (MIRT536670)
- hsa-mir-4778-5p (MIRT536671)
- hsa-mir-2355-3p (MIRT556947)
- hsa-mir-676-3p (MIRT556948)
- hsa-mir-6820-3p (MIRT702738)
- hsa-mir-3164 (MIRT702739)
- hsa-mir-3118 (MIRT702740)
- hsa-mir-134-5p (MIRT702741)
- hsa-mir-3607-5p (MIRT702742)
- hsa-mir-3177-5p (MIRT721898)
- hsa-mir-4252 (MIRT721899)
- hsa-mir-20b-3p (MIRT721900)
- hsa-mir-3137 (MIRT721901)
- hsa-mir-449b-3p (MIRT721902)
- hsa-mir-892a (MIRT721903)
miRNA Products
- Search ViGene Biosciences for IL6ST
Clone Products
- OriGene clones in human for IL6ST
- OriGene ORF clones in human,mouse,rat for IL6ST
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL6ST
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for IL6ST (gp130)
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for IL6ST gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IL6ST gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IL6ST gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL6ST Gene
Localization for IL6ST Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL6ST Gene
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 5 |
| cytosol | 2 |
| golgi apparatus | 2 |
| peroxisome | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030425 | dendrite | IEA | -- |
Pathways & Interactions for IL6ST Gene
More details on SuperPathways for IL6ST| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Interleukin-3, 5 and GM-CSF signaling | ||
| 2 | IL27-mediated signaling events | ||
| 3 | Interleukin-6 family signaling | ||
| 4 | RAF-independent MAPK1/3 activation | ||
| 5 | PEDF Induced Signaling |
.61
|
Pathways by source for IL6ST Gene
1 Cell Signaling Technology pathway for IL6ST Gene
9 BioSystems pathways for IL6ST Gene
12 Reactome pathways for IL6ST Gene
9 GeneGo (Thomson Reuters) pathways for IL6ST Gene
5 R&D Systems pathways for IL6ST Gene
6 Qiagen pathways for IL6ST Gene
Interacting Proteins for IL6ST Gene
Selected Interacting proteins:
P40189-IL6RB_HUMAN
ENSP00000338799
for IL6ST Gene via
MINT
STRING
UniProtKB
I2D
SIGNOR curated interactions for IL6ST Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005977 | glycogen metabolic process | IEA | -- |
| GO:0010575 | positive regulation of vascular endothelial growth factor production | TAS | 10744750 |
| GO:0010613 | positive regulation of cardiac muscle hypertrophy | TAS | 10744750 |
| GO:0019221 | cytokine-mediated signaling pathway | IDA | 2261637 |
| GO:0042511 | positive regulation of tyrosine phosphorylation of Stat1 protein | IMP | 14764690 |
Drugs & Compounds for IL6ST Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| SC 144 | Pharma | Gp130 inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for IL6ST Gene
| Compound | Action | Cas Number |
|---|---|---|
| SC 144 | Gp130 inhibitor | 895158-95-9 |
Drug Products
- ApexBio compounds for IL6ST
Transcripts for IL6ST Gene
mRNA/cDNA for IL6ST Gene
- (5) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (410) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IL6ST Gene
CRISPR Products
-
OriGene CRISPR knockouts for IL6ST
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL6ST
- GenScript: Design CRISPR guide RNA sequences for IL6ST
miRNA Products
- Search ViGene Biosciences for IL6ST
Clone Products
- OriGene clones in human for IL6ST
- OriGene ORF clones in human,mouse,rat for IL6ST
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL6ST
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for IL6ST (gp130)
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - |
Expression for IL6ST Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
- Bone (Muscoskeletal System)
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Cartilage (Muscoskeletal System)
- Bone Marrow Stromal Cells Bone Marrow
-
Liver (Hepatobiliary System)
- Hepatoblasts Liver Bud
-
Epithelial Cells
- Hepatoblasts Liver Bud
- Trophoblast (Extraembryonic Tissues)
- Adipose (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Ovary (Reproductive System)
This gene is overexpressed in Bone marrow mesenchymal stem cell (34.5), Serum (14.9), and Amniocyte (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL6ST Gene
SOURCE GeneReport for Unigene cluster for IL6ST Gene Hs.532082
mRNA Expression by UniProt/SwissProt for IL6ST Gene
P40189-IL6RB_HUMAN
Tissue specificity:
Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561).
Primer Products
-
OriGene qPCR primer pairs for IL6ST
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for IL6ST Gene
Orthologs for IL6ST Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | IL6ST 35 |
|
||
| IL6ST 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | IL6ST 35 |
|
||
| IL6ST 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Il6st 35 |
|
||
| Il6st 16 |
|
||||
| Il6st 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | IL6ST 35 |
|
||
| IL6ST 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Il6st 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | IL6ST 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IL6ST 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | IL6ST 35 |
|
||
| GP130 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | IL6ST 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | il6st 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | il6st 35 |
|
||
| il6st 36 |
|
OneToOne |
- Species with no ortholog for IL6ST:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for IL6ST Gene
(2) SIMAP similar genes for IL6ST Gene using alignment to 8 proteins:
Pseudogenes.org Pseudogenes for IL6ST Gene
Variants for IL6ST Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036165 | A colorectal cancer sample | ||||
| rs1063560 | - | 55,976,257(-) | CTTGG(C/G)TAGTG | nc-transcript-variant, reference, missense | |
| rs2228044 | - | 55,968,325(-) | GGGAT(C/G)GTGGA | nc-transcript-variant, reference, missense | |
| rs2228043 | - | 55,956,103(-) | GCTAT(C/G)TAGCA | nc-transcript-variant, reference, missense, utr-variant-3-prime | |
| rs2228046 | - | 55,954,899(-) | ATATA(C/T)ACTTG | intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime |
Residual Variation Intolerance Score:
36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.43;
90.95% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IL6ST Gene
Disorders for IL6ST Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kaposi sarcoma |
|
|
| myeloma |
|
|
| rheumatoid arthritis |
|
|
| preterm premature rupture of the membranes |
|
|
Search IL6ST in MalaCards
View complete list of genes associated with diseases
Relevant External Links for IL6ST
No data available for UniProtKB/Swiss-Prot and Genatlas for IL6ST Gene
Publications for IL6ST Gene
- Molecular cloning and expression of an IL-6 signal transducer, gp130. (PMID: 2261637) Hibi M. … Kishimoto T. (Cell 1990) 2 3 4 23 67
- N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130. (PMID: 19915009) Waetzig G.H. … Seegert D. (J. Biol. Chem. 2010) 3 23
- Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. (PMID: 19020503) Rebouissou S. … Zucman-Rossi J. (Nature 2009) 3 23
- Raised expression of cytokine receptor gp130 subunit on peripheral lymphocytes of patients with active lupus. A useful tool for monitoring the disease activity? (PMID: 19213859) De La Torre M. … Blanco J. (Lupus 2009) 3 23
- Correlation of soluble gp130 serum concentrations with arterial blood pressure. (PMID: 19330911) Inta I. … Schwaninger M. (J. Hypertens. 2009) 3 23
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- Santa Cruz Biotechnology (SCBT) Antibodies for IL6ST
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Sources for IL6ST Gene
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