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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL6ST Gene

protein-coding GIFtS: 67
GCID: GC05M055230

Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)

Microbiology & Infectious Diseases Congress

87 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)¹ ²		GP130²
Membrane Glycoprotein 130² ³		Gp130 Of The Rheumatoid Arthritis Antigenic Peptide-Bearing Soluble Form²
Oncostatin-M Receptor Subunit Alpha² ³		Interleukin Receptor Beta Chain²
IL-6RB² ³		Interleukin-6 Receptor Subunit Beta²
CD130 Antigen² ³		Membrane Glycoprotein Gp130²
IL-6 Receptor Subunit Beta² ³		CDw130³
IL-6R Subunit Beta² ³		IL-6R-beta³
CD130²		gp130³
CDW130²		Interleukin-6 Signal Transducer³

External Ids:	HGNC: 6021¹	Entrez Gene: 3572²	Ensembl: ENSG00000134352⁷	OMIM: 600694⁵	UniProtKB: P40189³

Export aliases for IL6ST gene to outside databases

Previous GC identifers: GC05M055398 GC05M056665 GC05M055207 GC05M055252 GC05M055272 GC05M052204

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL6ST Gene:

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6),

ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein

functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the

binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi

sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein.

Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis.

Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene

has been identified on chromosome 17. (provided by RefSeq, Jul 2010)

GeneCards Summary for IL6ST Gene:

IL6ST (interleukin 6 signal transducer (gp130, oncostatin M receptor)) is a protein-coding gene. Diseases associated with IL6ST include conjunctival disease, and cold-induced sweating syndrome, and among its related super-pathways are STAT3 Pathway and G-protein signaling Ras family GTPases in kinase cascades (scheme). GO annotations related to this gene include interleukin-6 receptor binding and protein homodimerization activity. An important paralog of this gene is OSMR.

UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189

Function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can

utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the

formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in

embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling

events

Gene Wiki entry for IL6ST (Glycoprotein 130) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NT_006713.15 NC_018916.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL6ST gene promoter:
STAT1 FOXF2 MEF-2 E4BP4 LCR-F1 GATA-1 STAT3 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL6ST promoter sequence

Search SABiosciences Chromatin IP Primers for IL6ST

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL6ST

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11.2

IL6ST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL6ST gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M055230: view genomic region (about GC identifiers)

Start:	55,230,923 bp from pter	End:	55,290,821 bp from pter
Size:	59,899 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189 (See protein sequence)

Recommended Name: Interleukin-6 receptor subunit beta precursor

Size: 918 amino acids; 103537 Da

Subunit: Interacts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM

receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer

binds two molecules of herpes virus IL6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST.

Interacts with HCK

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

6/9 PDB 3D structures from and Proteopedia for IL6ST (see all 9):

1BJ8 (3D)

1BQU (3D)

1I1R (3D)

1N2Q (3D)

1P9M (3D)

1PVH (3D)

Secondary accessions: A0N0L4 Q5FC04 Q9UQ41

Alternative splicing: 3 isoforms: P40189-1 P40189-2 P40189-3

Explore the universe of human proteins at neXtProt for IL6ST: NX_P40189

Explore proteomics data for IL6ST at MOPED

Post-translational modifications:

UniProtKB: Phosphorylation of Ser-782 down-regulates cell surface expression

UniProtKB: Heavily N-glycosylated

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P40189

IL6ST Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (3 alternative transcripts):

NP_001177910.1 NP_002175.2 NP_786943.1

ENSEMBL proteins:

ENSP00000370698 ENSP00000426224 ENSP00000462158 ENSP00000370694 ENSP00000370693

ENSP00000370686 ENSP00000435399 ENSP00000338799 ENSP00000370687 ENSP00000444456

ENSP00000463896

Reactome Protein details: P40189
Human Recombinant Protein Products for IL6ST:

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	Novus Biologicals IL6ST Proteins Novus Biologicals IL6ST Lysate
	Sino Biological Recombinant Protein for IL6ST Sino Biological Cell Lysate for IL6ST
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	8353278
GO:0005886	plasma membrane	TAS	--
GO:0005896	interleukin-6 receptor complex	IDA	12829785
GO:0005900	oncostatin-M receptor complex	IDA	8999038

IL6ST for ontologies About GeneDecksing

IL6ST Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL6ST
	R&D Systems Antibodies for IL6ST (gp130)
	Cell Signaling Technology (CST) Antibodies for IL6ST (gp130)
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	GenScript Custom Superior Antibodies Services for IL6ST
	Novus Biologicals IL6ST Antibodies
	Abcam antibodies for IL6ST
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for IL6ST
	LSBio Antibodies in human, mouse, rat for IL6ST

Assay Products for IL6ST:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for IL6ST
	R&D Systems ELISAs for IL6ST (gp130) (see all)
	GenScript Custom Assay Services for IL6ST
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

FN3: Fibronectin type III domain containing

CD: CD molecules

IL: Interleukins and interleukin receptors

IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin-6 receptor, β subunit

IL-6 receptor family

5 InterPro protein domains:

IPR015321 IL6_recept-bd

IPR003961 Fibronectin_type3

IPR013783 Ig-like_fold

IPR010457 IgC2-like_lig-bd

IPR003529 Hematopoietin_rcpt_Gp130_CS

Graphical View of Domain Structure for InterPro Entry P40189

ProtoNet protein and cluster: P40189

3 Blocks protein domains:

IPB003529 Long hematopoietin receptor

IPB003962 Fibronectin type III repeat signature

IPB010457 Ig-like C2-type

UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189

Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular

transport and cell-surface receptor binding

Domain: The box 1 motif is required for JAK interaction and/or activation

Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily

Similarity: Contains 5 fibronectin type-III domains

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

IL6ST for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IL6RB_HUMAN, P40189

Function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can

utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the

formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in

embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling

events

Induction: LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor

Genatlas biochemistry entry for IL6ST:

interleukin 6,signal transducer (GP130),needed for IL6R activity and signal transduction of the IL-6 related

cytokines,mediated by JAK kinases,ubiquitously expressed,with a membrane bound and an alternatively spliced

secreted form

Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004897	ciliary neurotrophic factor receptor activity	IDA	12643274
GO:0004915	contributes to interleukin-6 receptor activity	IGI	12643274
GO:0004921	interleukin-11 receptor activity	IEA	--
GO:0004923	contributes to leukemia inhibitory factor receptor activity	IGI	12643274
GO:0004924	contributes to oncostatin-M receptor activity	IDA	8999038

IL6ST for ontologies About GeneDecksing

Phenotypes:
15/19 MGI mutant phenotypes (inferred from 10 alleles) (MGI details for Il6st) (see all 19):

cardiovascular system	cellular	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	integument
limbs/digits/tail	liver/biliary system	mortality/aging	nervous system	normal

IL6ST for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for IL6ST: Il6st^tm1.1Wme Il6st^tm1Kish Il6st^tm1Ern Il6st^tm3Thir

inGenious Targeting Laboratory - Custom generated mouse model solutions for IL6ST

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL6ST

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL6ST

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL6ST

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL6ST
		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate IL6ST (see all 88):
		hsa-miR-548j hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-188-5p hsa-miR-4272 hsa-miR-106a hsa-miR-485-3p

		SwitchGear 3'UTR luciferase reporter plasmid: IL6ST 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for IL6ST
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL6ST

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IL6ST
			Sirion Biotech Customized adenovirus for overexpression of IL6ST

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for IL6ST (see all 15) OriGene ORF clones in mouse, rat for IL6ST OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): IL6ST (NM_002184)
		Sino Biological Human cDNA Clone for IL6ST
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6ST
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6ST
		Sirion Biotech Customized lentivirus for stable overexpression of IL6ST Customized lentivirus expression plasmids for stable overexpression of IL6ST

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL6ST
		Search LifeMap BioReagents cell lines for IL6ST

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6ST

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IL6ST About (see all 25)

See pathways by source

SuperPath

Contained pathways About

PEDF Induced Signaling

IL-6 Pathway

0.61

Cytokine-cytokine receptor interaction

0.43

G-protein signaling Ras family GTPases in kinase cascades (scheme)

Immune response Oncostatin M signaling via MAPK in human cells

0.39

Oncostatin M Signaling Pathway

0.37

IL27-mediated signaling events

IL27-mediated signaling events

0.38

Th1 Differentiation

0.38

Immune response Oncostatin M signaling via JAK-Stat in human cells

Immune response Oncostatin M signaling via JAK-Stat in human cells

0.30

Interleukin-6 signaling

0.30

Cytokine production by Th17 cells in CF (Mouse model)

Cytokine production by Th17 cells in CF

0.72

Cytokine production by Th17 cells in CF (Mouse model)

0.72

Pathways by source See SuperPaths
Show all pathways

5/6 EMD Millipore Pathways for IL6ST (see all 6)

	Transcription Androgen Receptor nuclear signaling
	Cell adhesion PLAU signaling
	Immune response IL-6 signaling pathway
	Immune response Oncostatin M signaling via MAPK in human cells
	Development CNTF receptor signaling

3 R&D Systems Pathways for IL6ST

	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
	Th1 Differentiation
	Th17 Differentiation

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL6ST (see all 6)

	OSM Pathway
	CNTF Signaling
	ERK5 Signaling
	NFAT and Cardiac Hypertrophy
	Signaling Involved in Cardiac Hypertrophy

1 Cell Signaling Technology (CST) Pathway for IL6ST

Jak/Stat Pathway

5/9 GeneGo (Thomson Reuters) Pathways for IL6ST (see all 9)

	Immune response IL-6 signaling pathway
	Transcription Androgen Receptor nuclear signaling
	Development CNTF receptor signaling
	Immune response Oncostatin M signaling via JAK-Stat in human cells
	Mucin expression in CF via IL-6, IL-17 signaling pathways

5/8 BioSystems Pathways for IL6ST (see all 8)

	MicroRNAs in cardiomyocyte hypertrophy
	Senescence and Autophagy
	Adipogenesis
	Oncostatin M Signaling Pathway
	IL-6 Signaling Pathway

4 Reactome Pathways for IL6ST

	Interleukin-6 signaling
	Cytokine Signaling in Immune system
	Signaling by Interleukins
	Immune System

3 Kegg Pathways (Kegg details for IL6ST):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	Viral carcinogenesis

IL6ST for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL6ST

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/76 Interacting proteins for IL6ST (P40189^{1, 2, 3} ENSP00000338799⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 76)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STAT1	P42224²^,³, ENSP00000354394⁴	MINT-8030726 MINT-8028344 MINT-8028329 I2D: score=1 STRING: ENSP00000354394
CNTF	P26441²^,³, ENSP00000355370⁴	MINT-62479 MINT-62480 I2D: score=2 STRING: ENSP00000355370
OSM	P13725²^,³, ENSP00000215781⁴	MINT-62481 MINT-62482 I2D: score=2 STRING: ENSP00000215781
LIF	P15018²^,³, ENSP00000249075⁴	MINT-62483 I2D: score=5 STRING: ENSP00000249075
IL6R	P08887³, ENSP00000357470⁴	I2D: score=5 STRING: ENSP00000357470

About this table

Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002675	positive regulation of acute inflammatory response	IC	8999038
GO:0002821	positive regulation of adaptive immune response	IC	14764690
GO:0005977	glycogen metabolic process	IEA	--
GO:0007165	signal transduction	--	--
GO:0008284	positive regulation of cell proliferation	IGI	8999038

IL6ST for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL6ST for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL6ST (IL6RB)

10/30 Novoseek inferred chemical compound relationships for IL6ST gene (see all 30) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gp 130	99.3	2328	19330911 (10), 18519587 (10), 12691915 (10), 7812050 (9) (see all 99)
tyrosine	64.4	106	7538109 (5), 10623831 (4), 10068651 (3), 8174677 (2) (see all 68)
phosphotyrosine	30.4	2	10946280 (1), 7812050 (1)
dexamethasone	17.4	6	8547658 (1), 8977259 (1), 7861551 (1), 1337986 (1) (see all 5)
ifn-alpha	15.7	3	12482347 (3)
retinoic acid	11.8	12	10695998 (3), 10381520 (2), 7949175 (2), 8547658 (1) (see all 6)
serine	10.1	5	10811661 (2), 8621406 (1), 8511589 (1), 7624343 (1)
ang ii	10	1	10720495 (1)
oligonucleotide	7.68	4	12513832 (2), 11482910 (1), 12695539 (1)
threonine	4.72	2	7624343 (1), 10811661 (1)

Search CenterWatch for drugs/clinical trials and news about IL6ST / IL6RB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL6ST gene (3 alternative transcripts):

NM_001190981.1 NM_002184.3 NM_175767.2

Unigene Clusters for IL6ST:

Interleukin 6 signal transducer (gp130, oncostatin M receptor)

Hs.532082 [show with all ESTs], Hs.706627

Unigene Representative Sequences: NM_002184, AB102803

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000381298(uc003jqp.3 uc010iwd.3 uc011cqk.2 uc003jqq.3 uc003jqr.3 uc010iwb.3)

ENST00000503773 ENST00000502326 ENST00000381294 ENST00000523039 ENST00000583149(uc010iwe.1)

ENST00000381293 ENST00000381286 ENST00000522633(uc010iwf.1) ENST00000423954

ENST00000506241 ENST00000577363 ENST00000336909 ENST00000381287 ENST00000536319

ENST00000396816

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate IL6ST (see all 88):
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		SwitchGear 3'UTR luciferase reporter plasmid: IL6ST 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 3): IL6ST (NM_002184)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL6ST

Additional mRNA sequence: AB102803.1

14 DOTS entries:

DT.95072775 DT.118660 DT.101977480 DT.95072808 DT.99957684 DT.100779983 DT.100779982 DT.120797204

DT.92422787 DT.75126328 DT.95072782 DT.120797188 DT.121007629 DT.97768242

24/410 AceView cDNA sequences (see all 410):

AA033718 BF590236 H85457 AA043274 AI288595 AW237619 AA909654 BE502242

BQ005125 BU751810 AA406546 AI769984 CA442319 T40054 BM508172 AL598252

BU620372 BX503730 AA890646 BM969205 AA099279 CF529976 NM_002184 BM985051

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for IL6ST About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15
SP1:
SP2:																			-
SP3:															-

ECgene alternative splicing isoforms for IL6ST

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL6ST expression in normal human tissues (normalized intensities) IL6ST embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TAAATGCTAA

About this image

IL6ST expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/9 selected tissues (see all 9) fully expand


Blood (Cardiovascular System) fully expand to see all 4 entries
T Helper Cells Thymus
cd4+ t cell

Bone (Muscoskeletal System) fully expand to see all 2 entries
Bone Marrow Stromal Cells Bone Marrow
Bone marrow-derived mesenchymal stem cells

Thymus (Hematopoietic System) fully expand to see all 2 entries
T Helper Cells Thymus

Liver (Hepatobiliary System) fully expand to see all 2 entries
Hepatoblasts Liver Bud

Uterus (Reproductive System)
endometrium

See IL6ST Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL6ST

SOURCE GeneReport for Unigene clusters: Hs.532082 Hs.706627

UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189

Tissue specificity: Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive

cells

SABiosciences Expression via Pathway-Focused PCR Arrays including IL6ST (see all 12):

Multiple Sclerosis in human mouse rat

Interferons & Receptors in human mouse rat

Wound Healing in human mouse rat

Stem Cell Signaling in human mouse rat

Notch Signaling Pathway in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL6ST gene from 5/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il6st^{1 , 5}	interleukin 6 signal transducer^{1, 5}	78.68(n)¹ 77.69(a)¹		13 (63.73 cM)⁵ 16195¹ NM_010560.3¹ NP_034690.3¹ 112475008⁵
chicken (Gallus gallus)	Aves	IL6ST¹	interleukin 6 signal transducer (gp130, oncostatin more	67.59(n) 60.89(a)		395684 NM_204871.1 NP_990202.1
lizard (Anolis carolinensis)	Reptilia	IL6ST⁶ -- (see all 3)	Uncharacterized protein (see all 3)	55(a) 25(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	2(2259922-2288478) AAWZ02039210(3284-8959)
African clawed frog (Xenopus laevis)	Amphibia	AF041846.1²	--	72.95(n)		AF041846.1
zebrafish (Danio rerio)	Actinopterygii	il6st¹	interleukin 6 signal transducer	50.02(n) 39.97(a)		100006778 NM_001113504.1 NP_001106976.1

ENSEMBL Gene Tree for IL6ST (if available)
TreeFam Gene Tree for IL6ST (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IL6ST gene

OSMR² CSF3R² IL31RA² LIFR² IL12RB2²

2 SIMAP similar genes for IL6ST using alignment to 8 protein entries: IL6RB_HUMAN (see all proteins):

gp130 IL23R

IL6ST for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for IL6ST
PGOHUM00000237232

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_036165⁴		A colorectal cancer sample⁴	--	see VAR_036165	2	T I	mis⁴		0	--	--	--	--
rs186099252^1,2	C	--	55230635(+)	`CTACAA/GGCAAG`	3	--	ds500¹		0	--	--	--	--
rs192256202^1,2		--	55230664(+)	`TCCTAC/GGGGGA`	3	--	ds500¹		0	--	--	--	--
rs73120471^1,2	C,F	--	55230800(+)	`TGAACC/TAGCAC`	3	--	ds500¹		1		WA	2
rs62363865^1,2	C,F	--	55230880(+)	`CCAGGG/CCTAAT`	3	--	ds500¹		9		NA WA CSA EA	370
rs75976988^1,2	C	--	55230929(+)	`TTTGGG/TTTTTT`	3	--	ut3¹		0	--	--	--	--
rs6450356^1,2	C,A	--	55231202(+)	`GCTTCG/TTATCT`	3	--	ut3¹ ese³		2		CSA WA	120
rs71622202^1,2	C	--	55231266(+)	`AATTTG/TGAGTT`	3	--	ut3¹		2		NA	4
rs10628013^1,2	C	--	55231311(+)	`CTTTT-/AG C/CAGCTATG`	6	--	cds¹		1		CSA	2
rs182763828^1,2		--	55231311(+)	`ACTTTG/TCTATG`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IL6ST (55230923 - 55290821 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for IL6ST: About this table

Variant ID	Type	Subtype	PubMed ID
esv270483	CNV	Insertion	20981092
esv273490	CNV	Insertion	20981092
nsv830307	CNV	Gain	17160897

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 600694 OMIM disorders: --

20/87 diseases for IL6ST (see all 87): About MalaCards

conjunctival disease cold-induced sweating syndrome kaposi's sarcoma breast carcinoma in situ

hepatocellular adenoma preterm premature rupture of the membranes plasmacytoma prolactinoma

sleep disorder plasmodium falciparum malaria rheumatoid arthritis myeloma

aggressive periodontitis essential thrombocythemia status epilepticus congestive heart failure

arthritis chronic fatigue syndrome hyperandrogenism sarcoma

IL6ST for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/45 Novoseek inferred disease relationships for IL6ST gene (see all 45) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	81	143	11721361 (3), 8145045 (2), 9630704 (2), 7919380 (2) (see all 99)
myeloma	70.6	27	12646637 (3), 14637393 (3), 12515619 (3), 7713920 (2) (see all 15)
response acute phase	49	3	8662795 (1), 12830005 (1), 9404669 (1)
plasmacytoma	43.7	4	8145046 (2), 8137932 (1)
choriocarcinoma	30.6	2	8583009 (1), 15373762 (1)
inflammation	28.2	4	15837947 (1), 7538109 (1), 17664290 (1), 17903270 (1)
necrosis	22.1	8	8720493 (2), 19631179 (1), 8547494 (1), 11171064 (1) (see all 7)
rheumatoid arthritis	18.3	10	16646038 (2), 10880057 (1), 12510348 (1)
herpes	16.1	1	10848977 (1)
tumors	14.1	17	8720493 (2), 9951579 (2), 10480339 (1), 18317962 (1) (see all 15)

Genetic Association Database (GAD): IL6ST
Human Genome Epidemiology (HuGE) Navigator: IL6ST (23 documents)

Export disorders for IL6ST gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL6ST gene, integrated from 9 sources (see all 616):
(articles sorted by number of sources associating them with IL6ST)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and expression of an IL-6 signal transducer, gp130. (PubMed id 2261637)^{1, 2, 3, 9} Hibi M.... Kishimoto T. (1990)
Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis. (PubMed id 10880057)^{1, 2, 9} Tanaka M.... Nakao K. (2000)
Phosphorylation of human gp130 at Ser-782 adjacent to the di-leucine internalization motif. Effects on expression and signaling. (PubMed id 10811661)^{1, 2, 9} Gibson R.M....Nathanson N.M. (2000)
Structure of an extracellular gp130 cytokine receptor signaling complex. (PubMed id 11251120)^{1, 2, 9} Chow D.-C.... Garcia K.C. (2001)
Crystal structure of a cytokine-binding region of gp130. (PubMed id 9501088)^{1, 2, 9} Bravo J.... Jones E.Y. (1998)
Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PubMed id 8999038)^{1, 2, 9} Mosley B....Cosman D. (1996)
Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)^{1, 4} Lee K.M....Lan Q. (2010)
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)^{1, 4} Johnatty S.E.... . (2010)
Genome-wide association study meta-analysis identifie s seven new rheumatoid arthritis risk loci. (PubMed id 20453842)^{1, 4} Stahl E.A....Plenge R.M. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3572	HGNC: 6021	AceView: IL6ST	Ensembl:ENSG00000134352	euGenes: HUgn3572
ECgene: IL6ST	Kegg: 3572	H-InvDB: IL6ST

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL6ST	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL6ST	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for IL6ST gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IL6ST gene:
Search GeneIP for patents involving IL6ST

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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IL6ST Gene

Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)

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IL6ST Gene

Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)

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