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IL6ST Gene

protein-coding GIFtS: 68
GCID: GC05M055230

Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)¹ ²		GP130²
Membrane Glycoprotein 130² ³		Gp130 Of The Rheumatoid Arthritis Antigenic Peptide-Bearing Soluble Form²
Oncostatin-M Receptor Subunit Alpha² ³		Interleukin Receptor Beta Chain²
IL-6RB² ³		Interleukin-6 Receptor Subunit Beta²
CD130 Antigen² ³		Membrane Glycoprotein Gp130²
IL-6 Receptor Subunit Beta² ³		CDw130³
IL-6R Subunit Beta² ³		IL-6R-beta³
CD130²		gp130³
CDW130²		Interleukin-6 Signal Transducer³

External Ids:	HGNC: 6021¹	Entrez Gene: 3572²	Ensembl: ENSG00000134352⁷	OMIM: 600694⁵	UniProtKB: P40189³

Export aliases for IL6ST gene to outside databases

Previous GC identifers: GC05M055398 GC05M056665 GC05M055207 GC05M055252 GC05M055272 GC05M052204

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL6ST Gene:

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6),

ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein

functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the

binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi

sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein.

Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis.

Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene

has been identified on chromosome 17. (provided by RefSeq, Jul 2010)

GeneCards Summary for IL6ST Gene:

IL6ST (interleukin 6 signal transducer (gp130, oncostatin M receptor)) is a protein-coding gene. Diseases associated with IL6ST include conjunctival disease, and cold-induced sweating syndrome. GO annotations related to this gene include interleukin-6 receptor binding and protein homodimerization activity. An important paralog of this gene is OSMR.

UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189

Function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can

utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the

formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in

embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling

events

Gene Wiki entry for IL6ST (Glycoprotein 130) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000005.10 NT_034772.7 NC_018916.2

Regulatory elements:

Regulatory transcription factor binding sites in the IL6ST gene promoter:
STAT1 FOXF2 MEF-2 E4BP4 LCR-F1 GATA-1 STAT3 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL6ST promoter sequence

Search Chromatin IP Primers for IL6ST

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL6ST

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11.2

IL6ST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL6ST gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M055230: view genomic region (about GC identifiers)

Start:	55,230,923 bp from pter	End:	55,290,821 bp from pter
Size:	59,899 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189 (See protein sequence)

Recommended Name: Interleukin-6 receptor subunit beta precursor

Size: 918 amino acids; 103537 Da

Subunit: Interacts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM

receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer

binds two molecules of herpes virus 8/HHV-8 protein vIL-6. Component of a hexamer of two molecules each of IL6,

IL6R and IL6ST. Interacts with HCK

Selected PDB 3D structures from and Proteopedia for IL6ST (see all 9):

1BJ8 (3D)

1BQU (3D)

1I1R (3D)

1N2Q (3D)

1P9M (3D)

1PVH (3D)

Secondary accessions: A0N0L4 Q5FC04 Q9UQ41

Alternative splicing: 3 isoforms: P40189-1 P40189-2 P40189-3

Explore the universe of human proteins at neXtProt for IL6ST: NX_P40189

Explore proteomics data for IL6ST at MOPED

Post-translational modifications:

Phosphorylation of Ser-782 down-regulates cell surface expression¹

Heavily N-glycosylated¹

Glycosylation² at Asn43, Asn83, Asn131, Asn157, Asn227, Asn379, Asn383, Asn390, Asn553, Asn564

Modification sites at PhosphoSitePlus

See IL6ST Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_001177910.1 NP_002175.2 NP_786943.1

ENSEMBL proteins:

ENSP00000370698 ENSP00000426224 ENSP00000462158 ENSP00000370694 ENSP00000370693

ENSP00000370686 ENSP00000435399 ENSP00000338799 ENSP00000370687 ENSP00000444456

ENSP00000463896

Reactome Protein details: P40189

IL6ST Human Recombinant Protein Products:

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	R&D Systems Recombinant & Natural Proteins for IL6ST (gp130)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for IL6ST OriGene Custom MassSpec OriGene Custom Protein Services for IL6ST
	GenScript Custom Purified and Recombinant Proteins Services for IL6ST
	Novus Biologicals IL6ST Proteins Novus Biologicals IL6ST Lysate
	Sino Biological Recombinant Protein for IL6ST Sino Biological Cell Lysate for IL6ST
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

IL6ST Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL6ST
	R&D Systems Antibodies for IL6ST (gp130)
	Cell Signaling Technology (CST) Antibodies for IL6ST (gp130)
	OriGene Antibodies for IL6ST OriGene Custom Antibody Services for IL6ST
	Novus Biologicals IL6ST Antibodies
	Abcam antibodies for IL6ST
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for IL6ST
	LSBio Antibodies in human, mouse, rat for IL6ST

IL6ST Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for IL6ST
	R&D Systems ELISAs for IL6ST (gp130) (see all)
	GenScript Custom Assay Services for IL6ST
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

FN3: Fibronectin type III domain containing

CD: CD molecules

IL: Interleukins and interleukin receptors

IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin-6 receptor, beta subunit

IL-6 receptor family

5 InterPro protein domains:

IPR015321 IL-6_rcpt_alpha-bd

IPR003961 Fibronectin_type3

IPR013783 Ig-like_fold

IPR010457 IgC2-like_lig-bd

IPR003529 Hematopoietin_rcpt_Gp130_CS

Graphical View of Domain Structure for InterPro Entry P40189

ProtoNet protein and cluster: P40189

3 Blocks protein domains:

IPB003529 Long hematopoietin receptor

IPB003962 Fibronectin type III repeat signature

IPB010457 Ig-like C2-type

UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189

Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular

transport and cell-surface receptor binding

Domain: The box 1 motif is required for JAK interaction and/or activation

Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily

Similarity: Contains 5 fibronectin type-III domains

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

IL6ST for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: IL6RB_HUMAN, P40189

Function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can

utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the

formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in

embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling

events

Induction: LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor

Genatlas biochemistry entry for IL6ST:

interleukin 6,signal transducer (GP130),needed for IL6R activity and signal transduction of the IL-6 related

cytokines,mediated by JAK kinases,ubiquitously expressed,with a membrane bound and an alternatively spliced

secreted form

Gene Ontology (GO): Selected molecular function terms (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004897	ciliary neurotrophic factor receptor activity	IDA	12643274
GO:0004915	contributes to interleukin-6 receptor activity	IGI	12643274
GO:0004921	interleukin-11 receptor activity	IEA	--
GO:0004923	contributes to leukemia inhibitory factor receptor activity	IGI	12643274
GO:0004924	contributes to oncostatin-M receptor activity	IDA	8999038

IL6ST for ontologies About GeneDecksing

Phenotypes:
Selected MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Il6st) (see all 19):

cardiovascular system	cellular	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size/body	hematopoietic system	homeostasis/metabolism	immune system	integument
limbs/digits/tail	liver/biliary system	mortality/aging	nervous system	normal

IL6ST for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for IL6ST: Il6st^tm1.1Wme Il6st^tm1Kish Il6st^tm1Ern Il6st^tm3Thir

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL6ST

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL6ST

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL6ST

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL6ST

miRNA Products:		miRTarBase miRNAs that target IL6ST: hsa-mir-335-5p (MIRT017169), hsa-mir-215-5p (MIRT024434), hsa-mir-192-5p (MIRT026283), hsa-mir-615-3p (MIRT040397), hsa-mir-590-3p (MIRT016213)

		Block miRNA regulation of human, mouse, rat IL6ST using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate IL6ST (see all 88):
		hsa-miR-548j hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-188-5p hsa-miR-4272 hsa-miR-106a hsa-miR-485-3p

		SwitchGear 3'UTR luciferase reporter plasmid: IL6ST 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for IL6ST
		Predesigned siRNA for gene silencing in human, mouse, rat IL6ST

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL6ST

Clone Products:		OriGene clones in human, mouse for IL6ST (see all 15) OriGene ORF clones in mouse, rat for IL6ST OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): IL6ST (NM_002184)
		Sino Biological Human cDNA Clone for IL6ST
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6ST
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6ST

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL6ST
		Browse ESI BIO Cell Lines and PureStem Progenitors for IL6ST

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6ST

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

IL6RB_HUMAN, P40189: Isoform 1: Cell membrane; Single-pass type I membrane protein

IL6RB_HUMAN, P40189: Isoform 2: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
plasma membrane	5
golgi apparatus	3
peroxisome	2
cytosol	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	8353278
GO:0005886	plasma membrane	TAS	--
GO:0005896	interleukin-6 receptor complex	IDA	12829785
GO:0005900	oncostatin-M receptor complex	IDA	8999038

IL6ST for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IL6ST About (see all 25)

See pathways by source

SuperPath

Contained pathways About

PEDF Induced Signaling

IL-6 Pathway

0.61

Cytokine-cytokine receptor interaction

0.43

G protein signaling Ras family GTPases in kinase cascades scheme

Immune response Oncostatin M signaling via MAPK in human cells

0.39

Oncostatin M Signaling Pathway

0.37

Th1 Differentiation

IL27-mediated signaling events

0.38

Th1 Differentiation

0.38

Cytokine production by Th17 cells in CF

Cytokine production by Th17 cells in CF

0.72

Cytokine production by Th17 cells in CF Mouse model

0.72

CNTF Signaling

CNTF Signaling

0.50

OSM Pathway

0.46

Pathways by source See SuperPaths
Show all pathways

3 R&D Systems Pathways for IL6ST

	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
	Th1 Differentiation
	Th17 Differentiation

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL6ST (see all 6)

	OSM Pathway
	CNTF Signaling
	ERK5 Signaling
	NFAT and Cardiac Hypertrophy
	Signaling Involved in Cardiac Hypertrophy

1 Cell Signaling Technology (CST) Pathway for IL6ST

Jak/Stat Pathway

Selected GeneGo (Thomson Reuters) Pathways for IL6ST (see all 9)

	Immune response IL-6 signaling pathway
	Transcription Androgen Receptor nuclear signaling
	Development CNTF receptor signaling
	Immune response Oncostatin M signaling via JAK-Stat in human cells
	Mucin expression in CF via IL-6, IL-17 signaling pathways

Selected BioSystems Pathways for IL6ST (see all 9)

	MicroRNAs in cardiomyocyte hypertrophy
	Senescence and Autophagy
	Adipogenesis
	Oncostatin M Signaling Pathway
	Physiological and Pathological Hypertrophy of the Heart

1 Reactome Pathway for IL6ST

Interleukin-6 signaling

3 Kegg Pathways (Kegg details for IL6ST):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	Viral carcinogenesis

IL6ST for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including IL6ST (see all 12):

Multiple Sclerosis in human mouse rat

Interferons & Receptors in human mouse rat

Wound Healing in human mouse rat

Stem Cell Signaling in human mouse rat

Notch Signaling Pathway in human mouse rat

Interactions:

GeneGlobe Interaction Network for IL6ST

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for IL6ST (P40189^{1, 2, 3} ENSP00000338799⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 78)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STAT1	P42224²^,³, ENSP00000354394⁴	MINT-8030726 MINT-8028344 MINT-8028329 I2D: score=1 STRING: ENSP00000354394
CNTF	P26441²^,³, ENSP00000355370⁴	MINT-62479 MINT-62480 I2D: score=2 STRING: ENSP00000355370
OSM	P13725²^,³, ENSP00000215781⁴	MINT-62481 MINT-62482 I2D: score=2 STRING: ENSP00000215781
LIF	P15018²^,³, ENSP00000249075⁴	MINT-62483 I2D: score=5 STRING: ENSP00000249075
IL6R	P08887³, ENSP00000357470⁴	I2D: score=5 STRING: ENSP00000357470

About this table

Gene Ontology (GO): Selected biological process terms (see all 25): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002675	positive regulation of acute inflammatory response	IC	8999038
GO:0002821	positive regulation of adaptive immune response	IC	14764690
GO:0005977	glycogen metabolic process	IEA	--
GO:0007165	signal transduction	--	--
GO:0008284	positive regulation of cell proliferation	IGI	8999038

IL6ST for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for IL6ST (IL6RB)

Selected Novoseek inferred chemical compound relationships for IL6ST gene (see all 30) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gp 130	99.3	2328	19330911 (10), 18519587 (10), 12691915 (10), 7812050 (9) (see all 99)
tyrosine	64.4	106	7538109 (5), 10623831 (4), 10068651 (3), 8174677 (2) (see all 68)
phosphotyrosine	30.4	2	10946280 (1), 7812050 (1)
dexamethasone	17.4	6	8547658 (1), 8977259 (1), 7861551 (1), 1337986 (1) (see all 5)
ifn-alpha	15.7	3	12482347 (3)
retinoic acid	11.8	12	10695998 (3), 10381520 (2), 7949175 (2), 8547658 (1) (see all 6)
serine	10.1	5	10811661 (2), 8621406 (1), 8511589 (1), 7624343 (1)
ang ii	10	1	10720495 (1)
oligonucleotide	7.68	4	12513832 (2), 11482910 (1), 12695539 (1)
threonine	4.72	2	7624343 (1), 10811661 (1)

IL6ST for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for IL6ST gene (3 alternative transcripts):

NM_001190981.1 NM_002184.3 NM_175767.2

Unigene Cluster for IL6ST:

Interleukin 6 signal transducer (gp130, oncostatin M receptor)

Hs.532082 [show with all ESTs]

Unigene Representative Sequence: NM_002184

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000381298(uc003jqp.3 uc010iwd.3 uc011cqk.2 uc003jqq.3 uc003jqr.3 uc010iwb.3)

ENST00000503773 ENST00000502326 ENST00000381294 ENST00000523039 ENST00000583149(uc010iwe.1)

ENST00000381293 ENST00000381286 ENST00000522633(uc010iwf.1) ENST00000423954

ENST00000506241 ENST00000577363 ENST00000336909 ENST00000381287 ENST00000536319

ENST00000396816

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat IL6ST using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate IL6ST (see all 88):
		hsa-miR-548j hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-188-5p hsa-miR-4272 hsa-miR-106a hsa-miR-485-3p

		SwitchGear 3'UTR luciferase reporter plasmid: IL6ST 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for IL6ST
		Predesigned siRNA for gene silencing in human, mouse, rat IL6ST

Clone Products:		OriGene clones in human, mouse for IL6ST (see all 15) OriGene ORF clones in mouse, rat for IL6ST OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): IL6ST (NM_002184)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6ST
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6ST

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for IL6ST
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat IL6ST
		QuantiTect SYBR Green Assays in human, mouse, rat IL6ST
		QuantiFast Probe-based Assays in human, mouse, rat IL6ST

Additional mRNA sequence:

AB015706.1 AB074172.1 AB102799.1 AB102801.1 AB102802.1 AB102804.1 AL049265.1 BC071555.1

BC117402.1 BC117404.1 BC143842.1 M57230.1 S80479.1 U58146.1

14 DOTS entries:

DT.95072775 DT.118660 DT.101977480 DT.95072808 DT.99957684 DT.100779983 DT.100779982 DT.120797204

DT.92422787 DT.75126328 DT.95072782 DT.120797188 DT.121007629 DT.97768242

Selected AceView cDNA sequences (see all 410):

CA391624 BX395121 AA360515 AL046895 AI342252 T03921 BQ638294 AI474443

BU620372 AW772101 AI682866 AI452569 AA035282 AA099278 AW316668 AL703418

AW664329 AI564657 BU674152 BQ722055 NM_175767 BM353129 CF529726 CF529976

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for IL6ST About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15
SP1:
SP2:																			-
SP3:															-

ECgene alternative splicing isoforms for IL6ST

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IL6ST expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TAAATGCTAA

About this image

IL6ST expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 18) fully expand


Mesenchymal Stem Cells
Bone Marrow Stromal Cells Bone Marrow
Bone marrow-derived mesenchymal stem cells

Bone (Muscoskeletal System) fully expand to see all 3 entries
Bone Marrow Stromal Cells Bone Marrow
Bone marrow-derived mesenchymal stem cells

Cartilage (Muscoskeletal System)
Bone Marrow Stromal Cells Bone Marrow

Blood (Cardiovascular System) fully expand to see all 3 entries
T Helper Cells Peripheral Blood

Thymus (Hematopoietic System) fully expand to see all 2 entries
T Helper Cells Thymus

IL6ST Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

IL6ST Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.532082

UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189

Tissue specificity: Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive

cells

Pathway & Disease-focused RT² Profiler PCR Arrays including IL6ST (see all 12):

Multiple Sclerosis in human mouse rat

Interferons & Receptors in human mouse rat

Wound Healing in human mouse rat

Stem Cell Signaling in human mouse rat

Notch Signaling Pathway in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for IL6ST
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IL6ST gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il6st^{1 , 5}	interleukin 6 signal transducer^{1, 5}	78.46(n)¹ 77.29(a)¹		13 (63.73 cM)⁵ 16195¹ NM_010560.3¹ NP_034690.3¹ 112464070⁵
chicken (Gallus gallus)	Aves	IL6ST¹	interleukin 6 signal transducer (gp130, oncostatin more	67.51(n) 60.66(a)		395684 NM_204871.1 NP_990202.1
lizard (Anolis carolinensis)	Reptilia	IL6ST⁶	interleukin 6 signal transducer (gp130, oncostatin...	55(a)	1 ↔ 1	2(2259922-2288478)
African clawed frog (Xenopus laevis)	Amphibia	AF041846.1²	--	72.95(n)		AF041846.1
zebrafish (Danio rerio)	Actinopterygii	il6st¹	interleukin 6 signal transducer	50.55(n) 40.66(a)		100006778 NM_001113504.1 NP_001106976.1

ENSEMBL Gene Tree for IL6ST (if available)
TreeFam Gene Tree for IL6ST (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for IL6ST gene

OSMR² CSF3R² IL31RA² LIFR² IL12RB2²

2 SIMAP similar genes for IL6ST using alignment to 8 protein entries: IL6RB_HUMAN (see all proteins):

gp130 IL23R

IL6ST for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for IL6ST
PGOHUM00000237232

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_036165⁴		A colorectal cancer sample⁴	--	see VAR_036165	2	T I	mis⁴		0	--	--	--	--
rs186099252^1,2	C	--	55230635(+)	`CTACAA/GGCAAG`	3	--	ds500¹		0	--	--	--	--
rs192256202^1,2		--	55230664(+)	`TCCTAC/GGGGGA`	3	--	ds500¹		0	--	--	--	--
rs73120471^1,2	C,F	--	55230800(+)	`TGAACC/TAGCAC`	3	--	ds500¹		1		WA	2
rs62363865^1,2	C,F	--	55230880(+)	`CCAGGG/CCTAAT`	3	--	ds500¹		9		NA WA CSA EA	370
rs75976988^1,2	C	--	55230929(+)	`TTTGGG/TTTTTT`	3	--	ut3¹		0	--	--	--	--
rs6450356^1,2	C,A	--	55231202(+)	`GCTTCG/TTATCT`	3	--	ut3¹ ese³		2		CSA WA	120
rs71622202^1,2	C	--	55231266(+)	`AATTTG/TGAGTT`	3	--	ut3¹		2		NA	4
rs10628013^1,2	C	--	55231311(+)	`CTTTT-/AG C/CAGCTATG`	6	--	cds¹		1		CSA	2
rs182763828^1,2		--	55231311(+)	`ACTTTG/TCTATG`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IL6ST (55230923 - 55290821 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for IL6ST: About this table

Variant ID	Type	Subtype	PubMed ID
esv270483	CNV	Insertion	20981092
esv273490	CNV	Insertion	20981092
nsv830307	CNV	Gain	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing IL6ST

DNA2.0 Custom Variant and Variant Library Synthesis for IL6ST

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600694 OMIM disorders: --

Selected diseases for IL6ST (see all 93):
About MalaCards

conjunctival disease cold-induced sweating syndrome kaposi's sarcoma breast carcinoma in situ

plasmacytoma arteriovenous fistula hepatocellular adenoma preterm premature rupture of the membranes

prolactinoma sleep disorder castleman's disease plasmodium falciparum malaria

aggressive periodontitis status epilepticus myeloma rheumatoid arthritis

congestive heart failure essential thrombocythemia arthritis chronic fatigue syndrome

IL6ST for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Selected Novoseek inferred disease relationships for IL6ST gene (see all 45) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	81	143	11721361 (3), 8145045 (2), 9630704 (2), 7919380 (2) (see all 99)
myeloma	70.6	27	12646637 (3), 14637393 (3), 12515619 (3), 7713920 (2) (see all 15)
response acute phase	49	3	8662795 (1), 12830005 (1), 9404669 (1)
plasmacytoma	43.7	4	8145046 (2), 8137932 (1)
choriocarcinoma	30.6	2	8583009 (1), 15373762 (1)
inflammation	28.2	4	15837947 (1), 7538109 (1), 17664290 (1), 17903270 (1)
necrosis	22.1	8	8720493 (2), 19631179 (1), 8547494 (1), 11171064 (1) (see all 7)
rheumatoid arthritis	18.3	10	16646038 (2), 10880057 (1), 12510348 (1)
herpes	16.1	1	10848977 (1)
tumors	14.1	17	8720493 (2), 9951579 (2), 10480339 (1), 18317962 (1) (see all 15)

Genetic Association Database (GAD): IL6ST
Human Genome Epidemiology (HuGE) Navigator: IL6ST (23 documents)

Export disorders for IL6ST gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for IL6ST gene, integrated from 10 sources (see all 624):
(articles sorted by number of sources associating them with IL6ST)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and expression of an IL-6 signal transducer, gp130. (PubMed id 2261637)^{1, 2, 3, 9} Hibi M.... Kishimoto T. (Cell 1990)
Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis. (PubMed id 10880057)^{1, 2, 9} Tanaka M.... Nakao K. (J. Clin. Invest. 2000)
Phosphorylation of human gp130 at Ser-782 adjacent to the di-leucine internalization motif. Effects on expression and signaling. (PubMed id 10811661)^{1, 2, 9} Gibson R.M....Nathanson N.M. (J. Biol. Chem. 2000)
Structure of an extracellular gp130 cytokine receptor signaling complex. (PubMed id 11251120)^{1, 2, 9} Chow D.-C.... Garcia K.C. (Science 2001)
Crystal structure of a cytokine-binding region of gp130. (PubMed id 9501088)^{1, 2, 9} Bravo J.... Jones E.Y. (EMBO J. 1998)
Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PubMed id 8999038)^{1, 2, 9} Mosley B....Cosman D. (J. Biol. Chem. 1996)
Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)^{1, 4} Lee K.M....Lan Q. (Am. J. Hematol. 2010)
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PubMed id 20628624)^{1, 4} Johnatty S.E.... . (PLoS Genet. 2010)
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PubMed id 20453842)^{1, 4} Stahl E.A....Plenge R.M. (Nat. Genet. 2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3572	HGNC: 6021	AceView: IL6ST	Ensembl:ENSG00000134352	euGenes: HUgn3572
ECgene: IL6ST	Kegg: 3572	H-InvDB: IL6ST

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for IL6ST	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL6ST	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for IL6ST gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IL6ST gene:
Search GeneIP for patents involving IL6ST

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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IL6ST Gene

Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)

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IL6ST Gene

Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)

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