IL6ST Gene

Aliases
for IL6ST gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC05M055398 GC05M056665 GC05M055207 GC05M055252 GC05M055272 GC05M052204

Summaries
for IL6ST gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for IL6ST gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000005.9  NT_034772.7  NC_018916.2  

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL6ST promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL6ST

IL6ST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M055230:  view genomic region     (about GC identifiers)

Proteins
for IL6ST gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Selected PDB 3D structures from and Proteopedia for IL6ST (see all 9):

1BJ8 (3D)        1BQU (3D)        1I1R (3D)        1N2Q (3D)        1P9M (3D)        1PVH (3D)    

Explore the universe of human proteins at neXtProt for IL6ST: NX_P40189

Explore proteomics data for IL6ST at MOPED

Post-translational modifications: 

IL6ST Human Recombinant Protein Products:

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	R&D Systems Recombinant & Natural Proteins for IL6ST (gp130)
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	Novus Biologicals IL6ST Proteins Novus Biologicals IL6ST Lysate
	Sino Biological Recombinant Protein for IL6ST Sino Biological Cell Lysate for IL6ST
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for IL6ST
	Search GeneTex for Proteins for IL6ST
	antibodies-online proteins for IL6ST (5 products)
	antibodies-online peptides for IL6ST

IL6ST Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL6ST
	R&D Systems Antibodies for IL6ST (gp130)
	Cell Signaling Technology (CST) Antibodies for IL6ST  (gp130)
	OriGene Antibodies for IL6ST OriGene Custom Antibody Services for IL6ST
	Novus Biologicals IL6ST Antibodies
	Abcam antibodies for IL6ST
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for IL6ST
	antibodies-online antibodies for IL6ST (109 products)

IL6ST Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for IL6ST
	R&D Systems ELISAs for IL6ST (gp130)         (see all)
	GenScript Custom Assay Services for IL6ST
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for IL6ST
	antibodies-online kits for IL6ST (6 products)

Domains /
Families
for IL6ST gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P40189

Find genes that share domains with IL6ST           About GenesLikeMe

Function
for IL6ST gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

Selected MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Il6st)

genOway: Develop your customized and physiologically relevant rodent model for IL6ST

miRNA Products:		miRTarBase miRNAs that target IL6ST: hsa-mir-335-5p (MIRT017169), hsa-mir-215-5p (MIRT024434), hsa-mir-192-5p (MIRT026283), hsa-mir-615-3p (MIRT040397), hsa-mir-590-3p (MIRT016213)
		Block miRNA regulation of human, mouse, rat IL6ST using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate IL6ST (see all 88):
		hsa-miR-548j hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-188-5p hsa-miR-4272 hsa-miR-106a hsa-miR-485-3p
		SwitchGear 3'UTR luciferase reporter plasmid: IL6ST 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for IL6ST
		Predesigned siRNA for gene silencing in human, mouse, rat IL6ST

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for IL6ST

Clone Products:		OriGene clones in human, mouse for IL6ST (see all 15) OriGene ORF clones in mouse, rat for IL6ST OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): IL6ST (NM_002184)
		Sino Biological Human cDNA Clone for IL6ST
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6ST
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6ST

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL6ST
		Browse ESI BIO Cell Lines and PureStem Progenitors for IL6ST

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6ST

Localization
for IL6ST gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5
plasma membrane	5
golgi apparatus	3
peroxisome	2
cytosol	1

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Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

Pathways & Interactions
for IL6ST gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for IL6ST About   (see all 25)   See pathways by source

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	SuperPath	Contained pathways About
1	PEDF Induced Signaling	IL-6 Pathway 0.61 Cytokine-cytokine receptor interaction 0.43
2	Th1 Differentiation	Th1 Differentiation 0.38 IL27-mediated signaling events 0.38
3	G-protein signaling Ras family GTPases in kinase cascades (scheme)	Immune response Oncostatin M signaling via MAPK in human cells 0.39 Oncostatin M Signaling Pathway 0.37
4	Cytokine production by Th17 cells in CF	Cytokine production by Th17 cells in CF 0.72 Cytokine production by Th17 cells in CF (Mouse model) 0.72
5	CNTF Signaling	CNTF Signaling 0.50 OSM Pathway 0.46

3 R&D Systems Pathways for IL6ST

	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
	Th1 Differentiation
	Th17 Differentiation

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL6ST

	OSM Pathway
	CNTF Signaling
	ERK5 Signaling
	NFAT and Cardiac Hypertrophy
	Signaling Involved in Cardiac Hypertrophy

1 Cell Signaling Technology (CST) Pathway for IL6ST

Jak/Stat Pathway

Selected GeneGo (Thomson Reuters) Pathways for IL6ST

	Immune response IL-6 signaling pathway
	Transcription Androgen Receptor nuclear signaling
	Development CNTF receptor signaling
	Immune response Oncostatin M signaling via JAK-Stat in human cells
	Mucin expression in CF via IL-6, IL-17 signaling pathways

Selected BioSystems Pathways for IL6ST

	MicroRNAs in cardiomyocyte hypertrophy
	Senescence and Autophagy
	Adipogenesis
	Oncostatin M Signaling Pathway
	Physiological and Pathological Hypertrophy of the Heart

1 Reactome Pathway for IL6ST

Interleukin-6 signaling

3 Kegg Pathways  (Kegg details for IL6ST)

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	Viral carcinogenesis

Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

Drugs & Compounds
for IL6ST gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for IL6ST gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for IL6ST gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IL6ST expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TAAATGCTAA

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Mesenchymal Stem Cells
Bone Marrow Stromal Cells Bone Marrow
Bone marrow-derived mesenchymal stem cells
Bone (Muscoskeletal System)    fully expand to see all 3 entries
Bone Marrow Stromal Cells Bone Marrow
Bone marrow-derived mesenchymal stem cells
Cartilage (Muscoskeletal System)
Bone Marrow Stromal Cells Bone Marrow
Blood (Cardiovascular System)    fully expand to see all 3 entries
T Helper Cells Peripheral Blood
Thymus (Hematopoietic System)    fully expand to see all 2 entries
T Helper Cells Thymus

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for IL6ST
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL6ST
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		QuantiFast Probe-based Assays in human, mouse, rat IL6ST

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6ST

Orthologs
for IL6ST gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for IL6ST gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for IL6ST gene

OSMR²  CSF3R²  IL31RA²  LIFR²  IL12RB2²  

2 SIMAP similar genes for IL6ST using alignment to 8 protein entries:     IL6RB_HUMAN (see all proteins):

gp130    IL23R

Find genes that share paralogs with IL6ST           About GenesLikeMe


1 Pseudogenes.org Pseudogene for IL6ST
PGOHUM00000237232

Genomic Variants
for IL6ST gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IL6ST (see all 1226)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
VAR_0361654		A colorectal cancer sample4	--	see VAR_036165	2	T I	mis4		0	--	--	--	--
rs1860992521,2	C	--	55230635(+)	CTACAA/GGCAAG	3	--	ds5001		0	--	--	--	--
rs1922562021,2		--	55230664(+)	TCCTAC/GGGGGA	3	--	ds5001		0	--	--	--	--
rs731204711,2	C,F	--	55230800(+)	TGAACC/TAGCAC	3	--	ds5001		1		WA	2
rs623638651,2	C,F	--	55230880(+)	CCAGGG/CCTAAT	3	--	ds5001		9		NA WA CSA EA	370
rs759769881,2	C	--	55230929(+)	TTTGGG/TTTTTT	3	--	ut31		0	--	--	--	--
rs64503561,2	C,A	--	55231202(+)	GCTTCG/TTATCT	3	--	ut31 ese3		2		CSA WA	120
rs716222021,2	C	--	55231266(+)	AATTTG/TGAGTT	3	--	ut31		2		NA	4
rs106280131,2	C	--	55231311(+)	CTTTT-/AG        C/CAGCTATG	6	--	cds1		1		CSA	2
rs1827638281,2		--	55231311(+)	ACTTTG/TCTATG	3	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for IL6ST (55230923 - 55290821 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for IL6ST:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv270483	CNV	Insertion	20981092
esv273490	CNV	Insertion	20981092
nsv830307	CNV	Gain	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing IL6ST

DNA2.0 Custom Variant and Variant Library Synthesis for IL6ST

Disorders / Diseases
for IL6ST gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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6 diseases for IL6ST

Selected Novoseek inferred disease relationships for IL6ST gene (see all 45)    About this table

Publications
for IL6ST gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Molecular cloning and expression of an IL-6 signal transducer, gp130. (PubMed id 2261637)^{1, 2, 3, 9} Hibi M.... Kishimoto T. (Cell 1990)
2. Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis. (PubMed id 10880057)^{1, 2, 9} Tanaka M.... Nakao K. (J. Clin. Invest. 2000)
3. Phosphorylation of human gp130 at Ser-782 adjacent to the di-leucine internalization motif. Effects on expression and signaling. (PubMed id 10811661)^{1, 2, 9} Gibson R.M....Nathanson N.M. (J. Biol. Chem. 2000)
4. Structure of an extracellular gp130 cytokine receptor signaling complex. (PubMed id 11251120)^{1, 2, 9} Chow D.-C.... Garcia K.C. (Science 2001)
5. Crystal structure of a cytokine-binding region of gp130. (PubMed id 9501088)^{1, 2, 9} Bravo J.... Jones E.Y. (EMBO J. 1998)
6. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PubMed id 8999038)^{1, 2, 9} Mosley B....Cosman D. (J. Biol. Chem. 1996)
7. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)^{1, 4} Lee K.M....Lan Q. (Am. J. Hematol. 2010)
8. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)^{1, 4} Johnatty S.E.... . (PLoS Genet. 2010)
9. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PubMed id 20453842)^{1, 4} Stahl E.A....Plenge R.M. (Nat. Genet. 2010)
10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)

External Searches for IL6ST gene

Genome Databases showing IL6ST gene

Other Databases showing IL6ST gene

Specialized Databases showing IL6ST gene

Products
for IL6ST gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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