Aliases for IL6ST Gene
Aliases for IL6ST Gene
External Ids for IL6ST Gene
- HGNC: 6021
- Entrez Gene: 3572
- Ensembl: ENSG00000134352
- OMIM: 600694
- UniProtKB: P40189
Previous GeneCards Identifiers for IL6ST Gene
- GC05M055398
- GC05M056665
- GC05M055207
- GC05M055252
- GC05M055272
- GC05M052204
- GC05M055230
Summaries for IL6ST Gene
-
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
GeneCards Summary for IL6ST Gene
IL6ST (Interleukin 6 Signal Transducer) is a Protein Coding gene. Diseases associated with IL6ST include Kaposi Sarcoma and Leukemia. Among its related pathways are RAF-independent MAPK1/3 activation and Transcription Androgen Receptor nuclear signaling. GO annotations related to this gene include protein homodimerization activity and interleukin-6 receptor binding. An important paralog of this gene is CSF3R.
UniProtKB/Swiss-Prot for IL6ST Gene
-
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL6ST Gene
Genomics for IL6ST Gene
Regulatory Elements for IL6ST Gene
Enhancers for IL6ST Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around IL6ST on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the IL6ST gene promoter:
Regulatory Element Products
Genomic Location for IL6ST Gene
- Chromosome:
- 5
- Start:
- 55,935,095 bp from pter
- End:
- 55,994,993 bp from pter
- Size:
- 59,899 bases
- Orientation:
- Minus strand
Genomic View for IL6ST Gene
Genes around IL6ST on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q11.2 by Ensembl
- 5q11.2 by Entrez Gene
- 5q11.2 by HGNC
IL6ST Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL6ST Gene
Proteins for IL6ST Gene
-
Protein details for IL6ST Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P40189-IL6RB_HUMAN
- Recommended name:
- Interleukin-6 receptor subunit beta
- Protein Accession:
- P40189
- A0N0L4
- Q5FC04
- Q9UQ41
Protein attributes for IL6ST Gene
- Size:
- 918 amino acids
- Molecular mass:
- 103537 Da
- Quaternary structure:
-
- Component of a hexamer of two molecules each of IL6, IL6R and IL6ST (PubMed:12829785). Forms heterodimers composed of LIFR and IL6ST (type I OSM receptor) which are activated by LIF and OSM (PubMed:8999038). Also forms heterodimers composed of OSMR and IL6ST (type II receptor) which are activated by OSM but not by LIF (PubMed:8999038). Homodimer. The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6 (PubMed:11238858, PubMed:11251120). Interacts with HCK (PubMed:9406996). Interacts with INPP5D/SHIP1 (By similarity).
Three dimensional structures from OCA and Proteopedia for IL6ST Gene
Protein Expression for IL6ST Gene
Post-translational modifications for IL6ST Gene
- Heavily N-glycosylated (PubMed:11098061, PubMed:16335952, PubMed:19159218, PubMed:19139490, PubMed:11251120). Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding (PubMed:19915009).
- Phosphorylation of Ser-782 down-regulates cell surface expression.
- Glycosylation at isoforms=2, 343, posLast=8383, isoforms=2, 3131, isoforms=2, 3157, posLast=227227, isoforms=3379, isoforms=3383, posLast=390390, posLast=553553, and isoforms=3564
- Modification sites at PhosphoSitePlus
Other Protein References for IL6ST Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for IL6ST
- R&D Systems Antibodies for IL6ST (gp130)
- Cell Signaling Technology (CST) Antibodies for IL6ST (gp130)
- Novus Biologicals Antibodies for IL6ST
-
Cloud-Clone Corp. Antibodies for IL6ST
- Invitrogen Antibodies for IL6ST
- antibodies-online Antibodies for IL6ST: See all 159
- GeneTex IL6ST antibody for IL6ST
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL6ST
Protein Products
- R&D Systems Proteins and Enzymes for IL6ST (gp130)
-
OriGene Purified Proteins for IL6ST
- Search Origene for MassSpec and Protein Over-expression Lysates for IL6ST
- Origene Custom Protein Services for IL6ST
- Sino Biological Recombinant Proteins for IL6ST
- Sino Biological Cell Lysates for IL6ST
-
Cloud-Clone Corp. Proteins for IL6ST
- antibodies-online Proteins for IL6ST: See all 21
- Search antibodies-online for peptides
- Search GeneTex for Proteins for IL6ST
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for IL6ST
- R&D Systems Luminex Assays, ELISAs, and other biochemical assays for IL6ST (gp130)
-
Cloud-Clone Corp Assay Kits for IL6ST
- antibodies-online Kits for IL6ST: See all 11
No data available for DME Specific Peptides for IL6ST Gene
Domains & Families for IL6ST Gene
Gene Families for IL6ST Gene
Protein Domains for IL6ST Gene
Suggested Antigen Peptide Sequences for IL6ST Gene
Graphical View of Domain Structure for InterPro Entry
P40189UniProtKB/Swiss-Prot:
IL6RB_HUMAN :- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- Belongs to the type I cytokine receptor family. Type 2 subfamily.
- Domain:
-
- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- The box 1 motif is required for JAK interaction and/or activation.
- Family:
-
- Belongs to the type I cytokine receptor family. Type 2 subfamily.
Function for IL6ST Gene
Molecular function for IL6ST Gene
- GENATLAS Biochemistry:
- interleukin 6,signal transducer (GP130),needed for IL6R activity and signal transduction of the IL-6 related cytokines,mediated by JAK kinases,ubiquitously expressed,with a membrane bound and an alternatively spliced secreted form
- UniProtKB/Swiss-Prot Function:
- Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
- UniProtKB/Swiss-Prot Induction:
- LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004896 | cytokine receptor activity | IEA | -- |
| GO:0004897 | ciliary neurotrophic factor receptor activity | IDA | 12643274 |
| GO:0004915 | contributes_to interleukin-6 receptor activity | IDA | 2261637 |
| GO:0004921 | interleukin-11 receptor activity | IEA | -- |
| GO:0004923 | contributes_to leukemia inhibitory factor receptor activity | IDA | 8999038 |
Phenotypes for IL6ST Gene
- MGI mutant phenotypes for IL6ST:
-
inferred from 11 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- digestive/alimentary phenotype
- neoplasm
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- integument phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for IL6ST:
Animal Models for IL6ST Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IL6ST
-
-
ViGene Biosciences lentiviral particle packaged cDNA for IL6ST gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IL6ST gene
- Search ViGene Biosciences for IL6ST
CRISPR Products
-
OriGene CRISPR knockouts for IL6ST
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL6ST
- GenScript: Design CRISPR guide RNA sequences for IL6ST
miRNA for IL6ST Gene
- miRTarBase miRNAs that target IL6ST
-
- hsa-mir-590-3p (MIRT016213)
- hsa-mir-335-5p (MIRT017169)
- hsa-mir-215-5p (MIRT024434)
- hsa-mir-192-5p (MIRT026283)
- hsa-mir-615-3p (MIRT040397)
- hsa-mir-190a-3p (MIRT215958)
- hsa-mir-5011-5p (MIRT215961)
- hsa-mir-302c-3p (MIRT216008)
- hsa-mir-512-3p (MIRT216012)
- hsa-mir-4501 (MIRT216019)
- hsa-mir-25-3p (MIRT216029)
- hsa-mir-32-5p (MIRT216030)
- hsa-mir-92a-3p (MIRT216031)
- hsa-mir-363-3p (MIRT216033)
- hsa-mir-367-3p (MIRT216034)
- hsa-mir-92b-3p (MIRT216035)
- hsa-mir-4789-5p (MIRT216039)
- hsa-mir-6074 (MIRT216040)
- hsa-mir-4729 (MIRT216059)
- hsa-mir-4661-5p (MIRT216085)
- hsa-mir-559 (MIRT216093)
- hsa-mir-548b-5p (MIRT216094)
- hsa-mir-548a-5p (MIRT216095)
- hsa-mir-548c-5p (MIRT216096)
- hsa-mir-548d-5p (MIRT216098)
- hsa-mir-548j-5p (MIRT216100)
- hsa-mir-548h-5p (MIRT216101)
- hsa-mir-548i (MIRT216102)
- hsa-mir-548w (MIRT216103)
- hsa-mir-548y (MIRT216106)
- hsa-mir-548o-5p (MIRT216107)
- hsa-mir-548ab (MIRT216108)
- hsa-mir-548ad-5p (MIRT216109)
- hsa-mir-548ae-5p (MIRT216110)
- hsa-mir-548ak (MIRT216111)
- hsa-mir-548am-5p (MIRT216112)
- hsa-mir-548ap-5p (MIRT216113)
- hsa-mir-548aq-5p (MIRT216114)
- hsa-mir-548ar-5p (MIRT216115)
- hsa-mir-548as-5p (MIRT216116)
- hsa-mir-548au-5p (MIRT216117)
- hsa-mir-548ay-5p (MIRT216119)
- hsa-mir-548bb-5p (MIRT216120)
- hsa-mir-4650-3p (MIRT381714)
- hsa-mir-1303 (MIRT485468)
- hsa-mir-5589-3p (MIRT485469)
- hsa-mir-4272 (MIRT485470)
- hsa-mir-548p (MIRT485471)
- hsa-mir-3924 (MIRT493503)
- hsa-mir-4473 (MIRT493504)
- hsa-mir-6073 (MIRT493505)
- hsa-mir-4720-3p (MIRT493506)
- hsa-mir-4804-3p (MIRT493507)
- hsa-mir-4328 (MIRT493508)
- hsa-mir-7852-3p (MIRT493509)
- hsa-mir-6507-3p (MIRT493510)
- hsa-mir-8054 (MIRT493511)
- hsa-mir-548l (MIRT493512)
- hsa-mir-548k (MIRT493513)
- hsa-mir-548av-5p (MIRT493514)
- hsa-mir-223-3p (MIRT493515)
- hsa-mir-142-3p (MIRT493516)
- hsa-mir-520f-3p (MIRT493517)
- hsa-mir-1277-5p (MIRT511363)
- hsa-mir-6867-5p (MIRT511364)
- hsa-mir-223-5p (MIRT511365)
- hsa-mir-190b (MIRT511366)
- hsa-mir-190a-5p (MIRT511367)
- hsa-mir-511-3p (MIRT511368)
- hsa-mir-4766-3p (MIRT522996)
- hsa-mir-3941 (MIRT522997)
- hsa-mir-3908 (MIRT522998)
- hsa-mir-4703-5p (MIRT522999)
- hsa-mir-3942-5p (MIRT523000)
- hsa-mir-603 (MIRT523001)
- hsa-mir-362-3p (MIRT523002)
- hsa-mir-329-3p (MIRT523003)
- hsa-mir-8485 (MIRT523004)
- hsa-mir-5706 (MIRT536667)
- hsa-mir-4782-5p (MIRT536668)
- hsa-mir-516b-5p (MIRT536669)
- hsa-mir-488-5p (MIRT536670)
- hsa-mir-4778-5p (MIRT536671)
- hsa-mir-2355-3p (MIRT556947)
- hsa-mir-676-3p (MIRT556948)
- hsa-mir-6820-3p (MIRT702738)
- hsa-mir-3164 (MIRT702739)
- hsa-mir-3118 (MIRT702740)
- hsa-mir-134-5p (MIRT702741)
- hsa-mir-3607-5p (MIRT702742)
- hsa-mir-3177-5p (MIRT721898)
- hsa-mir-4252 (MIRT721899)
- hsa-mir-20b-3p (MIRT721900)
- hsa-mir-3137 (MIRT721901)
- hsa-mir-449b-3p (MIRT721902)
- hsa-mir-892a (MIRT721903)
miRNA Products
- Search ViGene Biosciences for IL6ST
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for IL6ST
- Browse OriGene Inhibitory RNA Products For IL6ST
-
ViGene Biosciences ready-to-package AAV shRNAs for IL6ST gene
Clone Products
- Sino Biological Human cDNA Clone for IL6ST
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for IL6ST
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL6ST
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for IL6ST (gp130)
Cell Line Products
-
Horizon Cell Lines for IL6ST
-
ViGene Biosciences adenoviral particle packaged cDNA for IL6ST gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IL6ST gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IL6ST gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL6ST Gene
Localization for IL6ST Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL6ST Gene
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| peroxisome | 2 |
| cytosol | 2 |
| golgi apparatus | 2 |
| cytoskeleton | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005896 | interleukin-6 receptor complex | IDA | 2261637 |
| GO:0005900 | oncostatin-M receptor complex | IDA | 8999038 |
| GO:0009897 | external side of plasma membrane | IEA | -- |
Pathways & Interactions for IL6ST Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL27-mediated signaling events | ||
| 2 | Interleukin-6 family signaling | ||
| 3 | RAF-independent MAPK1/3 activation | ||
| 4 | PEDF Induced Signaling |
.61
|
|
| 5 | Th17 Differentiation Pathway | ||
Pathways by source for IL6ST Gene
2 Sino Biological pathways for IL6ST Gene
1 Cell Signaling Technology pathway for IL6ST Gene
9 BioSystems pathways for IL6ST Gene
12 Reactome pathways for IL6ST Gene
5 KEGG pathways for IL6ST Gene
9 GeneGo (Thomson Reuters) pathways for IL6ST Gene
5 R&D Systems pathways for IL6ST Gene
6 Qiagen pathways for IL6ST Gene
Interacting Proteins for IL6ST Gene
Selected Interacting proteins:
P40189-IL6RB_HUMAN
ENSP00000338799
for IL6ST Gene via
MINT
STRING
IID
UniProtKB
SIGNOR curated interactions for IL6ST Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002675 | positive regulation of acute inflammatory response | IC | 8999038 |
| GO:0002821 | positive regulation of adaptive immune response | IC | 14764690 |
| GO:0005977 | glycogen metabolic process | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IGI | 8999038 |
Drugs & Compounds for IL6ST Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| SC 144 | Pharma | Gp130 inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for IL6ST Gene
| Compound | Action | Cas Number |
|---|---|---|
| SC 144 | Gp130 inhibitor | 895158-95-9 |
Drug Products
- ApexBio compounds for IL6ST
Transcripts for IL6ST Gene
mRNA/cDNA for IL6ST Gene
- (5) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (410) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IL6ST Gene
CRISPR Products
-
OriGene CRISPR knockouts for IL6ST
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL6ST
- GenScript: Design CRISPR guide RNA sequences for IL6ST
miRNA Products
- Search ViGene Biosciences for IL6ST
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for IL6ST
- Browse OriGene Inhibitory RNA Products For IL6ST
-
ViGene Biosciences ready-to-package AAV shRNAs for IL6ST gene
Clone Products
- Sino Biological Human cDNA Clone for IL6ST
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for IL6ST
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL6ST
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for IL6ST (gp130)
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - |
Expression for IL6ST Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
- Bone (Muscoskeletal System)
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Cartilage (Muscoskeletal System)
- Bone Marrow Stromal Cells Bone Marrow
-
Liver (Hepatobiliary System)
- Hepatoblasts Liver Bud
-
Epithelial Cells
- Hepatoblasts Liver Bud
- Trophoblast (Extraembryonic Tissues)
- Adipose (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Ovary (Reproductive System)
This gene is overexpressed in Bone marrow mesenchymal stem cell (34.5), Serum (14.9), and Amniocyte (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IL6ST Gene
NURSA nuclear receptor signaling pathways regulating expression of IL6ST Gene:
IL6STSOURCE GeneReport for Unigene cluster for IL6ST Gene:
Hs.532082mRNA Expression by UniProt/SwissProt for IL6ST Gene:
P40189-IL6RB_HUMAN
Tissue specificity:
Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561).
Evidence on tissue expression from TISSUES for IL6ST Gene
- Liver(4.6)
- Blood(4.4)
- Bone marrow(4.4)
- Nervous system(3.9)
- Stomach(2.6)
- Kidney(2.5)
- Spleen(2.5)
- Lung(2.4)
- Heart(2.3)
- Intestine(2.3)
- Pancreas(2.2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for IL6ST
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL6ST Gene
Orthologs for IL6ST Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IL6ST 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | IL6ST 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | IL6ST 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Il6st 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Il6st 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | IL6ST 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IL6ST 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | IL6ST 34 |
|
||
| GP130 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | IL6ST 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | il6st 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | il6st 34 35 |
|
- Species where no ortholog for IL6ST was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for IL6ST Gene
(2) SIMAP similar genes for IL6ST Gene using alignment to 8 proteins:
Pseudogenes.org Pseudogenes for IL6ST Gene
Variants for IL6ST Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036165 | A colorectal cancer sample | ||||
| rs1000024946 | -- | 55,941,947(+) | CTGTC(A/G)ACTAC | intron-variant | |
| rs1000219531 | -- | 55,940,338(+) | TCTGT(C/T)GAGTT | nc-transcript-variant, utr-variant-3-prime | |
| rs1000306985 | -- | 55,974,174(+) | AGTCA(G/T)ATTGG | intron-variant | |
| rs1000310224 | -- | 55,960,161(+) | TTACA(C/G)GTGTG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3306206 | CNV | mobile element insertion | 20981092 |
| esv3309217 | CNV | mobile element insertion | 20981092 |
| esv3337710 | CNV | insertion | 20981092 |
| esv3395799 | CNV | insertion | 20981092 |
| nsv598182 | CNV | loss | 21841781 |
| nsv830307 | CNV | gain | 17160897 |
| nsv968176 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.43;
90.95% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for IL6ST Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL6ST Gene
Disorders for IL6ST Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kaposi sarcoma |
|
|
| leukemia |
|
|
| preterm premature rupture of the membranes |
|
|
| breast carcinoma in situ |
|
|
| rheumatoid arthritis |
|
Search IL6ST in MalaCards
View complete list of genes associated with diseases
Relevant External Links for IL6ST
No data available for UniProtKB/Swiss-Prot and Genatlas for IL6ST Gene
Publications for IL6ST Gene
- Molecular cloning and expression of an IL-6 signal transducer, gp130. (PMID: 2261637) Hibi M. … Kishimoto T. (Cell 1990) 2 3 4 22 64
- N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130. (PMID: 19915009) Waetzig G.H. … Seegert D. (J. Biol. Chem. 2010) 3 4 22 64
- Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling. (PMID: 11238858) Li H. … Nicholas J. (J. Virol. 2001) 3 4 22 64
- Structure of an extracellular gp130 cytokine receptor signaling complex. (PMID: 11251120) Chow D.-C. … Garcia K.C. (Science 2001) 3 4 22 64
- Phosphorylation of human gp130 at Ser-782 adjacent to the di-leucine internalization motif. Effects on expression and signaling. (PMID: 10811661) Gibson R.M. … Nathanson N.M. (J. Biol. Chem. 2000) 3 4 22 64
Products for IL6ST Gene
- R&D Systems Antibodies for IL6ST (gp130)
- R&D Systems Proteins and Enzymes for IL6ST (gp130)
- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for IL6ST (gp130)
- R&D Systems cDNA Clones for IL6ST (gp130)
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- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for IL6ST
- Custom Assay ServicesOriGene ELISA Kits for IL6ST
- OriGene Purified Proteins for IL6ST
- Search Origene for MassSpec and Protein Over-expression Lysates for IL6ST
- Origene Custom Protein Services for IL6ST
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for IL6ST
- Browse OriGene Inhibitory RNA Products For IL6ST
- OriGene qPCR primer pairs for IL6ST
- OriGene CRISPR knockouts for IL6ST
- OriGene ORF clones in human for IL6ST
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IL6ST
- GenScript: Next-day shipping cDNA ORF clone for IL6ST in any vector
- GenScript Custom Purified and Recombinant Proteins Services for IL6ST
- GenScript Custom Assay Services for IL6ST
- GenScript Custom overexpressing Cell Line Services for IL6ST
- GenScript: Design CRISPR guide RNA sequences for IL6ST
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for IL6ST
- Cell Signaling Technology (CST) Antibodies for IL6ST (gp130)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for IL6ST
- Sino Biological Recombinant Proteins for IL6ST
- Sino Biological Cell Lysates for IL6ST
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for IL6ST
- Novus Biologicals proteins and lysates for IL6ST
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for IL6ST
- Cloud-Clone Corp. Proteins for IL6ST
- Cloud-Clone Corp Assay Kits for IL6ST
- Invitrogen Antibodies for IL6ST
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for IL6ST
- antibodies-online Antibodies for IL6ST: See all 159
- antibodies-online Kits for IL6ST: See all 11
- antibodies-online Proteins for IL6ST: See all 21
- Search antibodies-online for peptides
- GeneTex IL6ST antibody for IL6ST
- Search GeneTex for Proteins for IL6ST
- ViGene Biosciences adenoviral particle packaged cDNA for IL6ST gene
- ViGene Biosciences lentiviral particle packaged cDNA for IL6ST gene
- ViGene Biosciences ready-to-package AAV shRNAs for IL6ST gene
- Search ViGene Biosciences for IL6ST
- Santa Cruz Biotechnology (SCBT) Antibodies for IL6ST
- Search Santa Cruz Biotechnology (SCBT) for IL6ST siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IL6ST
- Horizon Cell Lines for IL6ST
- Cyagen custom Knockout/knockin (KOKI) mouse models for IL6ST
- VectorBuilder custom plasmid, inducible vectors for IL6ST
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL6ST
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for IL6ST Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (23) PharmGKB
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- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (141) ENCODE
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- (146) Cyagen
- (147) VectorBuilder
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- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer