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Aliases for IL6ST Gene

Aliases for IL6ST Gene

  • Interleukin 6 Signal Transducer 2 3
  • Oncostatin-M Receptor Subunit Alpha 3 4
  • IL-6 Receptor Subunit Beta 3 4
  • Membrane Glycoprotein 130 3 4
  • IL-6R Subunit Beta 3 4
  • CD130 Antigen 3 4
  • CDW130 3 4
  • IL-6RB 3 4
  • GP130 3 4
  • Gp130 Of The Rheumatoid Arthritis Antigenic Peptide-Bearing Soluble Form 3
  • Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) 2
  • Interleukin-6 Receptor Subunit Beta 3
  • Interleukin Receptor Beta Chain 3
  • Interleukin-6 Signal Transducer 4
  • Gp130, Oncostatin M Receptor 3
  • Membrane Glycoprotein Gp130 3
  • Oncostatin M Receptor 2
  • IL-6R-Beta 4
  • Gp130 2
  • CD130 3

External Ids for IL6ST Gene

Summaries for IL6ST Gene

Entrez Gene Summary for IL6ST Gene

  • The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

GeneCards Summary for IL6ST Gene

IL6ST (Interleukin 6 Signal Transducer) is a Protein Coding gene. Diseases associated with IL6ST include rheumatoid arthritis and kaposi sarcoma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and NFAT and Cardiac Hypertrophy. GO annotations related to this gene include protein homodimerization activity and interleukin-6 receptor binding. An important paralog of this gene is CSF3R.

UniProtKB/Swiss-Prot for IL6ST Gene

  • Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.

Gene Wiki entry for IL6ST Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL6ST Gene

Genomics for IL6ST Gene

Genomic Location for IL6ST Gene

55,935,095 bp from pter
55,994,993 bp from pter
59,899 bases
Minus strand

Genomic View for IL6ST Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL6ST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL6ST Gene

Regulatory Elements for IL6ST Gene

Proteins for IL6ST Gene

  • Protein details for IL6ST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-6 receptor subunit beta
    Protein Accession:
    Secondary Accessions:
    • A0N0L4
    • Q5FC04
    • Q9UQ41

    Protein attributes for IL6ST Gene

    918 amino acids
    Molecular mass:
    103537 Da
    Quaternary structure:
    • Interacts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST. Interacts with HCK.

    Three dimensional structures from OCA and Proteopedia for IL6ST Gene

    Alternative splice isoforms for IL6ST Gene


neXtProt entry for IL6ST Gene

Proteomics data for IL6ST Gene at MOPED

Post-translational modifications for IL6ST Gene

  • Heavily N-glycosylated.
  • Phosphorylation of Ser-782 down-regulates cell surface expression.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn43, Asn83, Asn131, Asn157, Asn227, Asn379, Asn383, Asn390, Asn553, and Asn564

No data available for DME Specific Peptides for IL6ST Gene

Domains for IL6ST Gene

Gene Families for IL6ST Gene

  • CD :CD molecules
  • FN3 :Fibronectin type III domain containing
  • IL :Interleukins and interleukin receptors


  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding:
    • P40189
  • The box 1 motif is required for JAK interaction and/or activation:
    • P40189
  • Contains 5 fibronectin type-III domains.:
    • P40189
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • P40189
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.:
    • P40189
genes like me logo Genes that share domains with IL6ST: view

Function for IL6ST Gene

Molecular function for IL6ST Gene

GENATLAS Biochemistry: interleukin 6,signal transducer (GP130),needed for IL6R activity and signal transduction of the IL-6 related cytokines,mediated by JAK kinases,ubiquitously expressed,with a membrane bound and an alternatively spliced secreted form
UniProtKB/Swiss-Prot Function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
UniProtKB/Swiss-Prot Induction: LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor.

Gene Ontology (GO) - Molecular Function for IL6ST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004897 ciliary neurotrophic factor receptor activity IDA 12643274
GO:0004915 contributes_to interleukin-6 receptor activity IDA 12643274
GO:0004921 interleukin-11 receptor activity IEA --
GO:0004923 contributes_to leukemia inhibitory factor receptor activity IDA 12643274
GO:0004924 contributes_to oncostatin-M receptor activity IDA 8999038
genes like me logo Genes that share ontologies with IL6ST: view
genes like me logo Genes that share phenotypes with IL6ST: view

Animal Models for IL6ST Gene

MGI Knock Outs for IL6ST:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL6ST Gene

Localization for IL6ST Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL6ST Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

Jensen Localization Image for IL6ST Gene COMPARTMENTS Subcellular localization image for IL6ST gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 3
peroxisome 2
cytosol 1

Gene Ontology (GO) - Cellular Components for IL6ST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 8353278
GO:0005886 plasma membrane TAS --
GO:0005896 interleukin-6 receptor complex IDA 12643274
GO:0005900 oncostatin-M receptor complex IDA 8999038
genes like me logo Genes that share ontologies with IL6ST: view

Pathways for IL6ST Gene

genes like me logo Genes that share pathways with IL6ST: view

Gene Ontology (GO) - Biological Process for IL6ST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002675 positive regulation of acute inflammatory response IC 8999038
GO:0002821 positive regulation of adaptive immune response IC 14764690
GO:0005977 glycogen metabolic process IEA --
GO:0007165 signal transduction --
GO:0008284 positive regulation of cell proliferation IGI 8999038
genes like me logo Genes that share ontologies with IL6ST: view

Compounds for IL6ST Gene

(30) Novoseek inferred chemical compound relationships for IL6ST Gene

Compound -log(P) Hits PubMed IDs
gp 130 99.3 601
tyrosine 64.4 85
phosphotyrosine 30.4 2
dexamethasone 17.4 5
ifn-alpha 15.7 3
genes like me logo Genes that share compounds with IL6ST: view

Transcripts for IL6ST Gene

Unigene Clusters for IL6ST Gene

Interleukin 6 signal transducer (gp130, oncostatin M receptor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL6ST Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP2: -
SP3: -

Relevant External Links for IL6ST Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL6ST Gene

mRNA expression in normal human tissues for IL6ST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL6ST Gene

SOURCE GeneReport for Unigene cluster for IL6ST Gene Hs.532082

mRNA Expression by UniProt/SwissProt for IL6ST Gene

Tissue specificity: Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells
genes like me logo Genes that share expressions with IL6ST: view

Orthologs for IL6ST Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL6ST Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL6ST 36
  • 99.6 (n)
  • 99.46 (a)
IL6ST 37
  • 99 (a)
(Bos Taurus)
Mammalia IL6ST 36
  • 90.26 (n)
  • 87.57 (a)
IL6ST 37
  • 87 (a)
(Canis familiaris)
Mammalia IL6ST 36
  • 92.04 (n)
  • 92.04 (a)
IL6ST 37
  • 90 (a)
(Mus musculus)
Mammalia Il6st 36
  • 78.46 (n)
  • 77.29 (a)
Il6st 16
Il6st 37
  • 77 (a)
(Monodelphis domestica)
Mammalia IL6ST 37
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia IL6ST 37
  • 66 (a)
(Rattus norvegicus)
Mammalia Il6st 36
  • 80.19 (n)
  • 78.95 (a)
(Gallus gallus)
Aves GP130 37
  • 60 (a)
IL6ST 36
  • 67.51 (n)
  • 60.66 (a)
(Anolis carolinensis)
Reptilia IL6ST 37
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia il6st 36
  • 56.9 (n)
  • 47.4 (a)
(Danio rerio)
Actinopterygii il6st 36
  • 50.55 (n)
  • 40.66 (a)
il6st 37
  • 35 (a)
Species with no ortholog for IL6ST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL6ST Gene

Gene Tree for IL6ST (if available)
Gene Tree for IL6ST (if available)

Paralogs for IL6ST Gene

Paralogs for IL6ST Gene

Selected SIMAP similar genes for IL6ST Gene using alignment to 8 proteins: Pseudogenes for IL6ST Gene

genes like me logo Genes that share paralogs with IL6ST: view

Variants for IL6ST Gene

Sequence variations from dbSNP and Humsavar for IL6ST Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs15311 -- 55,937,114(+) AAAGC(C/T)TGTGT utr-variant-3-prime, nc-transcript-variant
rs149370 -- 55,936,342(-) aaaaa(A/C)CCTAC utr-variant-3-prime, nc-transcript-variant
rs1048729 -- 55,940,135(-) atata(C/T)acaca utr-variant-3-prime, nc-transcript-variant
rs1048730 -- 55,939,454(-) ATATT(A/G)TTCAC utr-variant-3-prime, nc-transcript-variant
rs1048731 -- 55,939,449(-) GTTCA(C/G)ATTAG utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for IL6ST Gene

Variant ID Type Subtype PubMed ID
nsv830307 CNV Gain 17160897
esv270483 CNV Insertion 20981092
esv273490 CNV Insertion 20981092

Relevant External Links for IL6ST Gene

HapMap Linkage Disequilibrium report

Disorders for IL6ST Gene

(45) Novoseek inferred disease relationships for IL6ST Gene

Disease -log(P) Hits PubMed IDs
leukemia 81 108
myeloma 70.6 23
response acute phase 49 3
plasmacytoma 43.7 3
choriocarcinoma 30.6 2

Relevant External Links for IL6ST

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IL6ST: view

No data available for UniProtKB/Swiss-Prot for IL6ST Gene

Publications for IL6ST Gene

  1. Molecular cloning and expression of an IL-6 signal transducer, gp130. (PMID: 2261637) Hibi M. … Kishimoto T. (Cell 1990) 2 3 4 23
  2. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PMID: 8999038) Mosley B. … Cosman D. (J. Biol. Chem. 1996) 3 4 23
  3. Phosphorylation of human gp130 at Ser-782 adjacent to the di-leucine internalization motif. Effects on expression and signaling. (PMID: 10811661) Gibson R.M. … Nathanson N.M. (J. Biol. Chem. 2000) 3 4 23
  4. Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis. (PMID: 10880057) Tanaka M. … Nakao K. (J. Clin. Invest. 2000) 3 4 23
  5. Structure of an extracellular gp130 cytokine receptor signaling complex. (PMID: 11251120) Chow D.-C. … Garcia K.C. (Science 2001) 3 4 23

Products for IL6ST Gene

Sources for IL6ST Gene

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