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IL6ST Gene

protein-coding   GIFtS: 68
GCID: GC05M055230

Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)

  See IL6ST-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)1 2     GP1302
Membrane Glycoprotein 1302 3     Gp130 Of The Rheumatoid Arthritis Antigenic Peptide-Bearing Soluble Form2
Oncostatin-M Receptor Subunit Alpha2 3     Interleukin Receptor Beta Chain2
IL-6RB2 3     Interleukin-6 Receptor Subunit Beta2
CD130 Antigen2 3     Membrane Glycoprotein Gp1302
IL-6 Receptor Subunit Beta2 3     CDw1303
IL-6R Subunit Beta2 3     IL-6R-beta3
CD1302     gp1303
CDW1302     Interleukin-6 Signal Transducer3

External Ids:    HGNC: 60211   Entrez Gene: 35722   Ensembl: ENSG000001343527   OMIM: 6006945   UniProtKB: P401893   

Export aliases for IL6ST gene to outside databases

Previous GC identifers: GC05M055398 GC05M056665 GC05M055207 GC05M055252 GC05M055272 GC05M052204


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL6ST Gene:
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6),
ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein
functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the
binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi
sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein.
Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis.
Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene
has been identified on chromosome 17. (provided by RefSeq, Jul 2010)

GeneCards Summary for IL6ST Gene:
IL6ST (interleukin 6 signal transducer (gp130, oncostatin M receptor)) is a protein-coding gene. Diseases associated with IL6ST include conjunctival disease, and cold-induced sweating syndrome. GO annotations related to this gene include interleukin-6 receptor binding and protein homodimerization activity. An important paralog of this gene is OSMR.

UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189
Function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can
utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the
formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in
embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling
events

Gene Wiki entry for IL6ST (Glycoprotein 130) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL6ST gene promoter:
         STAT1   FOXF2   MEF-2   E4BP4   LCR-F1   GATA-1   STAT3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL6ST promoter sequence
   Search Chromatin IP Primers for IL6ST

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL6ST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

IL6ST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL6ST gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M055230:  view genomic region     (about GC identifiers)

Start:
55,230,923 bp from pter      End:
55,290,821 bp from pter
Size:
59,899 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189 (See protein sequence)
Recommended Name: Interleukin-6 receptor subunit beta precursor  
Size: 918 amino acids; 103537 Da
Subunit: Interacts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM
receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer
binds two molecules of herpes virus 8/HHV-8 protein vIL-6. Component of a hexamer of two molecules each of IL6,
IL6R and IL6ST. Interacts with HCK
Selected PDB 3D structures from and Proteopedia for IL6ST (see all 9):
1BJ8 (3D)        1BQU (3D)        1I1R (3D)        1N2Q (3D)        1P9M (3D)        1PVH (3D)    
Secondary accessions: A0N0L4 Q5FC04 Q9UQ41
Alternative splicing: 3 isoforms:  P40189-1   P40189-2   P40189-3   

Explore the universe of human proteins at neXtProt for IL6ST: NX_P40189

Explore proteomics data for IL6ST at MOPED

Post-translational modifications: 

  • Phosphorylation of Ser-782 down-regulates cell surface expression1
  • Heavily N-glycosylated1
  • Glycosylation2 at Asn43, Asn83, Asn131, Asn157, Asn227, Asn379, Asn383, Asn390, Asn553, Asn564
  • Modification sites at PhosphoSitePlus

  • See IL6ST Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001177910.1  NP_002175.2  NP_786943.1  

    ENSEMBL proteins: 
     ENSP00000370698   ENSP00000426224   ENSP00000462158   ENSP00000370694   ENSP00000370693  
     ENSP00000370686   ENSP00000435399   ENSP00000338799   ENSP00000370687   ENSP00000444456  
     ENSP00000463896  
    Reactome Protein details: P40189

    IL6ST Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL6ST (gp130)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IL6ST
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IL6ST
    GenScript Custom Purified and Recombinant Proteins Services for IL6ST
    Novus Biologicals IL6ST Proteins
    Novus Biologicals IL6ST Lysate
    Sino Biological Recombinant Protein for IL6ST
    Sino Biological Cell Lysate for IL6ST
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IL6ST 

    IL6ST Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL6ST
    R&D Systems Antibodies for IL6ST (gp130)
    Cell Signaling Technology (CST) Antibodies for IL6ST  (gp130)
    OriGene Antibodies for IL6ST
    OriGene Custom Antibody Services for IL6ST
    Novus Biologicals IL6ST Antibodies
    Abcam antibodies for IL6ST
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for IL6ST
    LSBio Antibodies in human, mouse, rat for IL6ST

    IL6ST Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL6ST
    R&D Systems ELISAs for IL6ST (gp130)         (see all)
    GenScript Custom Assay Services for IL6ST
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for IL6ST 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    CD: CD molecules
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin-6 receptor, beta subunit
    IL-6 receptor family

    5 InterPro protein domains:
     IPR015321 IL-6_rcpt_alpha-bd
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR010457 IgC2-like_lig-bd
     IPR003529 Hematopoietin_rcpt_Gp130_CS

    Graphical View of Domain Structure for InterPro Entry P40189

    ProtoNet protein and cluster: P40189

    3 Blocks protein domains:
    IPB003529 Long hematopoietin receptor
    IPB003962 Fibronectin type III repeat signature
    IPB010457 Ig-like C2-type


    UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Domain: The box 1 motif is required for JAK interaction and/or activation
    Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily
    Similarity: Contains 5 fibronectin type-III domains
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    Find genes that share domains with IL6ST           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL6RB_HUMAN, P40189
    Function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can
    utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the
    formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in
    embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling
    events
    Induction: LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor

         Genatlas biochemistry entry for IL6ST:
    interleukin 6,signal transducer (GP130),needed for IL6R activity and signal transduction of the IL-6 related
    cytokines,mediated by JAK kinases,ubiquitously expressed,with a membrane bound and an alternatively spliced
    secreted form

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004897ciliary neurotrophic factor receptor activity IDA12643274
    GO:0004915contributes to interleukin-6 receptor activity IGI12643274
    GO:0004921interleukin-11 receptor activity IEA--
    GO:0004923contributes to leukemia inhibitory factor receptor activity IGI12643274
    GO:0004924contributes to oncostatin-M receptor activity IDA8999038
         
    Find genes that share ontologies with IL6ST           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 11 alleles(MGI details for Il6st) (see all 19):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  liver/biliary system  mortality/aging  nervous system  normal 

    Find genes that share phenotypes with IL6ST           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL6ST: Il6sttm1.1Wme Il6sttm1Kish Il6sttm1Ern Il6sttm3Thir

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL6ST
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL6ST

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL6ST
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL6ST

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL6ST:
    hsa-mir-335-5p (MIRT017169), hsa-mir-215-5p (MIRT024434), hsa-mir-192-5p (MIRT026283), hsa-mir-615-3p (MIRT040397), hsa-mir-590-3p (MIRT016213)

    Block miRNA regulation of human, mouse, rat IL6ST using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL6ST (see all 88):
    hsa-miR-548j hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-188-5p hsa-miR-4272 hsa-miR-106a hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL6ST 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL6ST
    Predesigned siRNA for gene silencing in human, mouse, rat IL6ST

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL6ST

    Clone
    Products:
         
    OriGene clones in human, mouse for IL6ST (see all 15)
    OriGene ORF clones in mouse, rat for IL6ST
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IL6ST (NM_002184)
    Sino Biological Human cDNA Clone for IL6ST
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6ST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6ST

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL6ST
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL6ST 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6ST


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL6RB_HUMAN, P40189: Isoform 1: Cell membrane; Single-pass type I membrane protein
    IL6RB_HUMAN, P40189: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    golgi apparatus3
    peroxisome2
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA8353278
    GO:0005886plasma membrane TAS--
    GO:0005896interleukin-6 receptor complex IDA12829785
    GO:0005900oncostatin-M receptor complex IDA8999038

    Find genes that share ontologies with IL6ST           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL6ST About   (see all 25)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    IL-6 Pathway0.61
    Cytokine-cytokine receptor interaction0.43
    2G protein signaling Ras family GTPases in kinase cascades scheme
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Oncostatin M Signaling Pathway0.37
    3Th1 Differentiation
    IL27-mediated signaling events0.38
    Th1 Differentiation0.38
    4Cytokine production by Th17 cells in CF
    Cytokine production by Th17 cells in CF0.72
    Cytokine production by Th17 cells in CF Mouse model 0.72
    5CNTF Signaling
    CNTF Signaling0.50
    OSM Pathway0.46


    Find genes that share SuperPaths with IL6ST           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for IL6ST
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Th17 Differentiation

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL6ST (see all 6)
        OSM Pathway
    CNTF Signaling
    ERK5 Signaling
    NFAT and Cardiac Hypertrophy
    Signaling Involved in Cardiac Hypertrophy

    1 Cell Signaling Technology (CST) Pathway for IL6ST
        Jak/Stat Pathway

    Selected GeneGo (Thomson Reuters) Pathways for IL6ST (see all 9)
        Immune response IL-6 signaling pathway
    Transcription Androgen Receptor nuclear signaling
    Development CNTF receptor signaling
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Mucin expression in CF via IL-6, IL-17 signaling pathways

    Selected BioSystems Pathways for IL6ST (see all 9)
        MicroRNAs in cardiomyocyte hypertrophy
    Senescence and Autophagy
    Adipogenesis
    Oncostatin M Signaling Pathway
    Physiological and Pathological Hypertrophy of the Heart


    1 Reactome Pathway for IL6ST
        Interleukin-6 signaling


    3 Kegg Pathways  (Kegg details for IL6ST):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Viral carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL6ST (see all 12): 
              Multiple Sclerosis in human mouse rat
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL6ST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL6ST (P401891, 2, 3 ENSP000003387994) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT1P422242, 3, ENSP000003543944MINT-8030726 MINT-8028344 MINT-8028329 I2D: score=1 STRING: ENSP00000354394
    CNTFP264412, 3, ENSP000003553704MINT-62479 MINT-62480 I2D: score=2 STRING: ENSP00000355370
    OSMP137252, 3, ENSP000002157814MINT-62481 MINT-62482 I2D: score=2 STRING: ENSP00000215781
    LIFP150182, 3, ENSP000002490754MINT-62483 I2D: score=5 STRING: ENSP00000249075
    IL6RP088873, ENSP000003574704I2D: score=5 STRING: ENSP00000357470
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002675positive regulation of acute inflammatory response IC8999038
    GO:0002821positive regulation of adaptive immune response IC14764690
    GO:0005977glycogen metabolic process IEA--
    GO:0007165signal transduction ----
    GO:0008284positive regulation of cell proliferation IGI8999038

    Find genes that share ontologies with IL6ST           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL6ST (IL6RB)

    Selected Novoseek inferred chemical compound relationships for IL6ST gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 99.3 2328 19330911 (10), 18519587 (10), 12691915 (10), 7812050 (9) (see all 99)
    tyrosine 64.4 106 7538109 (5), 10623831 (4), 10068651 (3), 8174677 (2) (see all 68)
    phosphotyrosine 30.4 2 10946280 (1), 7812050 (1)
    dexamethasone 17.4 6 8547658 (1), 8977259 (1), 7861551 (1), 1337986 (1) (see all 5)
    ifn-alpha 15.7 3 12482347 (3)
    retinoic acid 11.8 12 10695998 (3), 10381520 (2), 7949175 (2), 8547658 (1) (see all 6)
    serine 10.1 5 10811661 (2), 8621406 (1), 8511589 (1), 7624343 (1)
    ang ii 10 1 10720495 (1)
    oligonucleotide 7.68 4 12513832 (2), 11482910 (1), 12695539 (1)
    threonine 4.72 2 7624343 (1), 10811661 (1)



    Find genes that share compounds with IL6ST           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL6ST gene (3 alternative transcripts): 
    NM_001190981.1  NM_002184.3  NM_175767.2  

    Unigene Cluster for IL6ST:

    Interleukin 6 signal transducer (gp130, oncostatin M receptor)
    Hs.532082  [show with all ESTs]
    Unigene Representative Sequence: NM_002184
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381298(uc003jqp.3 uc010iwd.3 uc011cqk.2 uc003jqq.3 uc003jqr.3 uc010iwb.3)
    ENST00000503773 ENST00000502326 ENST00000381294 ENST00000523039 ENST00000583149(uc010iwe.1)
    ENST00000381293 ENST00000381286 ENST00000522633(uc010iwf.1) ENST00000423954
    ENST00000506241 ENST00000577363 ENST00000336909 ENST00000381287 ENST00000536319
    ENST00000396816
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate IL6ST (see all 88):
    hsa-miR-548j hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-188-5p hsa-miR-4272 hsa-miR-106a hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL6ST 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL6ST
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): IL6ST (NM_002184)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6ST
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL6ST
      QuantiTect SYBR Green Assays in human, mouse, rat IL6ST
      QuantiFast Probe-based Assays in human, mouse, rat IL6ST

    Additional mRNA sequence: 

    AB015706.1 AB074172.1 AB102799.1 AB102801.1 AB102802.1 AB102804.1 AL049265.1 BC071555.1 
    BC117402.1 BC117404.1 BC143842.1 M57230.1 S80479.1 U58146.1 

    14 DOTS entries:

    DT.95072775  DT.118660  DT.101977480  DT.95072808  DT.99957684  DT.100779983  DT.100779982  DT.120797204 
    DT.92422787  DT.75126328  DT.95072782  DT.120797188  DT.121007629  DT.97768242 

    Selected AceView cDNA sequences (see all 410):

    CA391624 BX395121 AA360515 AL046895 AI342252 T03921 BQ638294 AI474443 
    BU620372 AW772101 AI682866 AI452569 AA035282 AA099278 AW316668 AL703418 
    AW664329 AI564657 BU674152 BQ722055 NM_175767 BM353129 CF529726 CF529976 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IL6ST    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                                                                
    SP2:                                                        -                                       
    SP3:                                            -                                                   


    ECgene alternative splicing isoforms for IL6ST

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IL6ST expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATGCTAA
    IL6ST Expression
    About this image


    IL6ST expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Mesenchymal Stem Cells
             Bone Marrow Stromal Cells Bone Marrow
             Bone marrow-derived mesenchymal stem cells
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow Stromal Cells Bone Marrow
             Bone marrow-derived mesenchymal stem cells
     
     Cartilage (Muscoskeletal System)
             Bone Marrow Stromal Cells Bone Marrow
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T Helper Cells Peripheral Blood
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
    IL6ST Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL6ST Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532082

    UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189
    Tissue specificity: Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive
    cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL6ST (see all 12): 
              Multiple Sclerosis in human mouse rat
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IL6ST
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL6ST
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6ST

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for IL6ST gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il6st1 , 5 interleukin 6 signal transducer1, 5 78.46(n)1
    77.29(a)1
      13 (63.73 cM)5
    161951  NM_010560.31  NP_034690.31 
     1124640705 
    chicken
    (Gallus gallus)
    Aves IL6ST1 interleukin 6 signal transducer (gp130, oncostatin more 67.51(n)
    60.66(a)
      395684  NM_204871.1  NP_990202.1 
    lizard
    (Anolis carolinensis)
    Reptilia IL6ST6
    interleukin 6 signal transducer (gp130, oncostatin...
    55(a)
    1 ↔ 1
    2(2259922-2288478)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF041846.12   -- 72.95(n)    AF041846.1 
    zebrafish
    (Danio rerio)
    Actinopterygii il6st1 interleukin 6 signal transducer 50.55(n)
    40.66(a)
      100006778  NM_001113504.1  NP_001106976.1 


    ENSEMBL Gene Tree for IL6ST (if available)
    TreeFam Gene Tree for IL6ST (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL6ST gene
    OSMR2  CSF3R2  IL31RA2  LIFR2  IL12RB22  
    2 SIMAP similar genes for IL6ST using alignment to 8 protein entries:     IL6RB_HUMAN (see all proteins):
    gp130    IL23R

    Find genes that share paralogs with IL6ST           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IL6ST
    PGOHUM00000237232


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL6ST (see all 1226)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361654
    A colorectal cancer sample4--see VAR_0361652 T I mis40--------
    rs1860992521,2
    C--55230635(+) CTACAA/GGCAAG 3 -- ds50010--------
    rs1922562021,2
    --55230664(+) TCCTAC/GGGGGA 3 -- ds50010--------
    rs731204711,2
    C,F--55230800(+) TGAACC/TAGCAC 3 -- ds50011Minor allele frequency- T:0.50WA 2
    rs623638651,2
    C,F--55230880(+) CCAGGG/CCTAAT 3 -- ds50019Minor allele frequency- C:0.10NA WA CSA EA 370
    rs759769881,2
    C--55230929(+) TTTGGG/TTTTTT 3 -- ut310--------
    rs64503561,2
    C,A--55231202(+) GCTTCG/TTATCT 3 -- ut31 ese32Minor allele frequency- T:0.07CSA WA 120
    rs716222021,2
    C--55231266(+) AATTTG/TGAGTT 3 -- ut312Minor allele frequency- T:0.25NA 4
    rs106280131,2
    C--55231311(+) CTTTT-/AG    
       C
    /CAG
    CTATG
    6 -- cds11CSA 2
    rs1827638281,2
    --55231311(+) ACTTTG/TCTATG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for IL6ST (55230923 - 55290821 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IL6ST:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270483CNV Insertion20981092
    esv273490CNV Insertion20981092
    nsv830307CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL6ST
    DNA2.0 Custom Variant and Variant Library Synthesis for IL6ST

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600694    OMIM disorders: --

    6 diseases for IL6ST:    
    About MalaCards
    conjunctival disease    cold-induced sweating syndrome    preterm premature rupture of the membranes    kaposi's sarcoma
    rheumatoid arthritis    malaria


    Find genes that share disorders with IL6ST           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL6ST gene (see all 45)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 81 143 11721361 (3), 8145045 (2), 9630704 (2), 7919380 (2) (see all 99)
    myeloma 70.6 27 12646637 (3), 14637393 (3), 12515619 (3), 7713920 (2) (see all 15)
    response acute phase 49 3 8662795 (1), 12830005 (1), 9404669 (1)
    plasmacytoma 43.7 4 8145046 (2), 8137932 (1)
    choriocarcinoma 30.6 2 8583009 (1), 15373762 (1)
    inflammation 28.2 4 15837947 (1), 7538109 (1), 17664290 (1), 17903270 (1)
    necrosis 22.1 8 8720493 (2), 19631179 (1), 8547494 (1), 11171064 (1) (see all 7)
    rheumatoid arthritis 18.3 10 16646038 (2), 10880057 (1), 12510348 (1)
    herpes 16.1 1 10848977 (1)
    tumors 14.1 17 8720493 (2), 9951579 (2), 10480339 (1), 18317962 (1) (see all 15)

    Genetic Association Database (GAD): IL6ST
    Human Genome Epidemiology (HuGE) Navigator: IL6ST (23 documents)

    Export disorders for IL6ST gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL6ST gene, integrated from 10 sources (see all 624):
    (articles sorted by number of sources associating them with IL6ST)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of an IL-6 signal transducer, gp130. (PubMed id 2261637)1, 2, 3, 9 Hibi M.... Kishimoto T. (Cell 1990)
    2. Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis. (PubMed id 10880057)1, 2, 9 Tanaka M.... Nakao K. (J. Clin. Invest. 2000)
    3. Phosphorylation of human gp130 at Ser-782 adjacent to the di-leucine internalization motif. Effects on expression and signaling. (PubMed id 10811661)1, 2, 9 Gibson R.M....Nathanson N.M. (J. Biol. Chem. 2000)
    4. Structure of an extracellular gp130 cytokine receptor signaling complex. (PubMed id 11251120)1, 2, 9 Chow D.-C.... Garcia K.C. (Science 2001)
    5. Crystal structure of a cytokine-binding region of gp130. (PubMed id 9501088)1, 2, 9 Bravo J.... Jones E.Y. (EMBO J. 1998)
    6. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PubMed id 8999038)1, 2, 9 Mosley B....Cosman D. (J. Biol. Chem. 1996)
    7. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    8. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    9. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1, 4 Stahl E.A....Plenge R.M. (Nat. Genet. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3572 HGNC: 6021 AceView: IL6ST Ensembl:ENSG00000134352 euGenes: HUgn3572
    ECgene: IL6ST Kegg: 3572 H-InvDB: IL6ST

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IL6ST Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL6ST Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IL6ST gene:
    Search GeneIP for patents involving IL6ST

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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