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Aliases for IL6ST Gene

Aliases for IL6ST Gene

  • Interleukin 6 Signal Transducer 2 3 5
  • Interleukin-6 Receptor Subunit Beta 2 3
  • Oncostatin-M Receptor Subunit Alpha 3 4
  • Gp130, Oncostatin M Receptor 2 3
  • IL-6 Receptor Subunit Beta 3 4
  • Membrane Glycoprotein 130 3 4
  • IL-6R Subunit Beta 3 4
  • CD130 Antigen 3 4
  • CDW130 3 4
  • IL-6RB 3 4
  • GP130 3 4
  • Gp130 Of The Rheumatoid Arthritis Antigenic Peptide-Bearing Soluble Form 3
  • Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) 2
  • Interleukin Receptor Beta Chain 3
  • Interleukin-6 Signal Transducer 4
  • Membrane Glycoprotein Gp130 3
  • IL-6R-Beta 4
  • CD130 3

External Ids for IL6ST Gene

Previous GeneCards Identifiers for IL6ST Gene

  • GC05M055398
  • GC05M056665
  • GC05M055207
  • GC05M055252
  • GC05M055272
  • GC05M052204
  • GC05M055230

Summaries for IL6ST Gene

Entrez Gene Summary for IL6ST Gene

  • The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

GeneCards Summary for IL6ST Gene

IL6ST (Interleukin 6 Signal Transducer) is a Protein Coding gene. Diseases associated with IL6ST include Leukemia and Kaposi Sarcoma. Among its related pathways are IL27-mediated signaling events and CNTF Signaling. GO annotations related to this gene include protein homodimerization activity and interleukin-6 receptor binding. An important paralog of this gene is CSF3R.

UniProtKB/Swiss-Prot for IL6ST Gene

  • Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).

Gene Wiki entry for IL6ST Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL6ST Gene

Genomics for IL6ST Gene

Regulatory Elements for IL6ST Gene

Enhancers for IL6ST Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F055973 0.6 ENCODE 18 +21.3 21342 1.1 IL6ST FLJ31104 ENSG00000238326 ANKRD55 ENSG00000264281
GH05F056054 0.5 Ensembl ENCODE 11.7 -62.4 -62393 6.0 HDGF FEZF1 YY1 ZNF143 FOS JUNB TBX21 PPARG ZNF518A KAT8 FLJ31104 IL6ST ENSG00000238326 RNU6-299P LOC105378976
GH05F056049 1.2 FANTOM5 Ensembl ENCODE 11.7 -55.6 -55608 2.4 ZNF146 RAD21 ZNF644 YY1 NR2F2 ZNF217 GATA3 HNF1A SCRT2 KDM1A FLJ31104 IL6ST ENSG00000238326 LOC105378976
GH05F056052 1 ENCODE 11.7 -58.3 -58342 1.5 CBX3 ZNF680 NR2F1 NR2F6 RARA FLJ31104 IL6ST ENSG00000238326 RNU6-299P LOC105378976
GH05F056078 0.7 Ensembl ENCODE 11.7 -83.9 -83908 1.4 SOX13 ZMYM3 ARID4B CEBPG EBF1 RAD21 YY1 HNF4G MTA2 HLF FLJ31104 IL6ST ENSG00000238326 LOC105378976 LOC101928419
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IL6ST on UCSC Golden Path with GeneCards custom track

Promoters for IL6ST Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001409459 1292 5000 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1

Genomic Location for IL6ST Gene

Chromosome:
5
Start:
55,935,095 bp from pter
End:
55,994,993 bp from pter
Size:
59,899 bases
Orientation:
Minus strand

Genomic View for IL6ST Gene

Genes around IL6ST on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL6ST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL6ST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL6ST Gene

Proteins for IL6ST Gene

  • Protein details for IL6ST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40189-IL6RB_HUMAN
    Recommended name:
    Interleukin-6 receptor subunit beta
    Protein Accession:
    P40189
    Secondary Accessions:
    • A0N0L4
    • Q5FC04
    • Q9UQ41

    Protein attributes for IL6ST Gene

    Size:
    918 amino acids
    Molecular mass:
    103537 Da
    Quaternary structure:
    • Component of a hexamer of two molecules each of IL6, IL6R and IL6ST (PubMed:12829785). Forms heterodimers composed of LIFR and IL6ST (type I OSM receptor) which are activated by LIF and OSM (PubMed:8999038). Also forms heterodimers composed of OSMR and IL6ST (type II receptor) which are activated by OSM but not by LIF (PubMed:8999038). Homodimer. The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6 (PubMed:11238858, PubMed:11251120). Interacts with HCK (PubMed:9406996). Interacts with INPP5D/SHIP1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for IL6ST Gene

    Alternative splice isoforms for IL6ST Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL6ST Gene

Post-translational modifications for IL6ST Gene

  • Heavily N-glycosylated (PubMed:11098061, PubMed:16335952, PubMed:19159218, PubMed:19139490, PubMed:11251120). Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding (PubMed:19915009).
  • Phosphorylation of Ser-782 down-regulates cell surface expression.
  • Glycosylation at Asn 43, Asn 83, Asn 131, Asn 157, Asn 227, Asn 379, Asn 383, Asn 390, Asn 553, and Asn 564
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IL6ST (gp130)

No data available for DME Specific Peptides for IL6ST Gene

Domains & Families for IL6ST Gene

Graphical View of Domain Structure for InterPro Entry

P40189

UniProtKB/Swiss-Prot:

IL6RB_HUMAN :
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
  • Contains 5 fibronectin type-III domains.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Family:
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.
genes like me logo Genes that share domains with IL6ST: view

Function for IL6ST Gene

Molecular function for IL6ST Gene

GENATLAS Biochemistry:
interleukin 6,signal transducer (GP130),needed for IL6R activity and signal transduction of the IL-6 related cytokines,mediated by JAK kinases,ubiquitously expressed,with a membrane bound and an alternatively spliced secreted form
UniProtKB/Swiss-Prot Function:
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
UniProtKB/Swiss-Prot Induction:
LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor.

Gene Ontology (GO) - Molecular Function for IL6ST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IEA --
GO:0004897 ciliary neurotrophic factor receptor activity IDA 12643274
GO:0004915 contributes_to interleukin-6 receptor activity IDA 2261637
GO:0004921 interleukin-11 receptor activity IEA --
GO:0004923 contributes_to leukemia inhibitory factor receptor activity IDA 8999038
genes like me logo Genes that share ontologies with IL6ST: view
genes like me logo Genes that share phenotypes with IL6ST: view

Animal Models for IL6ST Gene

MGI Knock Outs for IL6ST:

Animal Model Products

miRNA for IL6ST Gene

miRTarBase miRNAs that target IL6ST

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL6ST Gene

Localization for IL6ST Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL6ST Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL6ST Gene COMPARTMENTS Subcellular localization image for IL6ST gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
golgi apparatus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for IL6ST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0005896 interleukin-6 receptor complex IDA 2261637
GO:0005900 oncostatin-M receptor complex IDA 8999038
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with IL6ST: view

Pathways & Interactions for IL6ST Gene

genes like me logo Genes that share pathways with IL6ST: view

SIGNOR curated interactions for IL6ST Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for IL6ST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002675 positive regulation of acute inflammatory response IC 8999038
GO:0002821 positive regulation of adaptive immune response IC 14764690
GO:0005977 glycogen metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0008284 positive regulation of cell proliferation IGI 8999038
genes like me logo Genes that share ontologies with IL6ST: view

Drugs & Compounds for IL6ST Gene

(17) Drugs for IL6ST Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
SC 144 Pharma Gp130 inhibitor 0

(14) Additional Compounds for IL6ST Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for IL6ST Gene

Compound Action Cas Number
SC 144 Gp130 inhibitor 895158-95-9
genes like me logo Genes that share compounds with IL6ST: view

Transcripts for IL6ST Gene

Unigene Clusters for IL6ST Gene

Interleukin 6 signal transducer (gp130, oncostatin M receptor):
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL6ST Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: -
SP3: -

Relevant External Links for IL6ST Gene

GeneLoc Exon Structure for
IL6ST
ECgene alternative splicing isoforms for
IL6ST

Expression for IL6ST Gene

mRNA expression in normal human tissues for IL6ST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IL6ST Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (34.5), Serum (14.9), and Amniocyte (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IL6ST Gene



NURSA nuclear receptor signaling pathways regulating expression of IL6ST Gene:

IL6ST

SOURCE GeneReport for Unigene cluster for IL6ST Gene:

Hs.532082

mRNA Expression by UniProt/SwissProt for IL6ST Gene:

P40189-IL6RB_HUMAN
Tissue specificity: Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561).
genes like me logo Genes that share expression patterns with IL6ST: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for IL6ST Gene

Orthologs for IL6ST Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL6ST Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL6ST 34 35
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia IL6ST 34 35
  • 92.04 (n)
cow
(Bos Taurus)
Mammalia IL6ST 34 35
  • 90.26 (n)
rat
(Rattus norvegicus)
Mammalia Il6st 34
  • 80.19 (n)
mouse
(Mus musculus)
Mammalia Il6st 34 16 35
  • 78.46 (n)
oppossum
(Monodelphis domestica)
Mammalia IL6ST 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL6ST 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL6ST 34
  • 67.51 (n)
GP130 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL6ST 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il6st 34
  • 56.9 (n)
zebrafish
(Danio rerio)
Actinopterygii il6st 34 35
  • 50.55 (n)
Species where no ortholog for IL6ST was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL6ST Gene

ENSEMBL:
Gene Tree for IL6ST (if available)
TreeFam:
Gene Tree for IL6ST (if available)

Paralogs for IL6ST Gene

Paralogs for IL6ST Gene

(2) SIMAP similar genes for IL6ST Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for IL6ST Gene

genes like me logo Genes that share paralogs with IL6ST: view

Variants for IL6ST Gene

Sequence variations from dbSNP and Humsavar for IL6ST Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_036165 A colorectal cancer sample
rs10036745 -- 55,974,402(+) cacac(C/T)gcaac intron-variant
rs10040750 -- 55,974,561(+) ctcac(C/T)gcaac intron-variant
rs10043249 -- 55,950,523(+) AGAGC(G/T)AGACT intron-variant
rs10050978 -- 55,967,117(+) ccagc(A/C)tgacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL6ST Gene

Variant ID Type Subtype PubMed ID
esv3306206 CNV mobile element insertion 20981092
esv3309217 CNV mobile element insertion 20981092
esv3337710 CNV insertion 20981092
esv3395799 CNV insertion 20981092
nsv598182 CNV loss 21841781
nsv830307 CNV gain 17160897
nsv968176 CNV duplication 23825009

Variation tolerance for IL6ST Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.43; 90.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL6ST Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL6ST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL6ST Gene

Disorders for IL6ST Gene

MalaCards: The human disease database

(4) MalaCards diseases for IL6ST Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia
kaposi sarcoma
  • kaposi sarcoma, susceptibility to
rheumatoid arthritis
  • rheumatoid arthritis, progression of
preterm premature rupture of the membranes
  • preterm premature rupture of the membranes, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search IL6ST in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL6ST

Genetic Association Database (GAD)
IL6ST
Human Genome Epidemiology (HuGE) Navigator
IL6ST
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL6ST
genes like me logo Genes that share disorders with IL6ST: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL6ST Gene

Publications for IL6ST Gene

  1. Molecular cloning and expression of an IL-6 signal transducer, gp130. (PMID: 2261637) Hibi M. … Kishimoto T. (Cell 1990) 2 3 4 22 64
  2. N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130. (PMID: 19915009) Waetzig G.H. … Seegert D. (J. Biol. Chem. 2010) 3 4 22 64
  3. Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling. (PMID: 11238858) Li H. … Nicholas J. (J. Virol. 2001) 3 4 22 64
  4. Structure of an extracellular gp130 cytokine receptor signaling complex. (PMID: 11251120) Chow D.-C. … Garcia K.C. (Science 2001) 3 4 22 64
  5. Phosphorylation of human gp130 at Ser-782 adjacent to the di-leucine internalization motif. Effects on expression and signaling. (PMID: 10811661) Gibson R.M. … Nathanson N.M. (J. Biol. Chem. 2000) 3 4 22 64

Products for IL6ST Gene

Sources for IL6ST Gene

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