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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL6ST Gene

protein-coding   GIFtS: 67
GCID: GC05M055230

Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)1 2     GP1302
Membrane Glycoprotein 1302 3     Gp130 Of The Rheumatoid Arthritis Antigenic Peptide-Bearing Soluble Form2
Oncostatin-M Receptor Subunit Alpha2 3     Interleukin Receptor Beta Chain2
IL-6RB2 3     Interleukin-6 Receptor Subunit Beta2
CD130 Antigen2 3     Membrane Glycoprotein Gp1302
IL-6 Receptor Subunit Beta2 3     CDw1303
IL-6R Subunit Beta2 3     IL-6R-beta3
CD1302     gp1303
CDW1302     Interleukin-6 Signal Transducer3

External Ids:    HGNC: 60211   Entrez Gene: 35722   Ensembl: ENSG000001343527   OMIM: 6006945   UniProtKB: P401893   

Export aliases for IL6ST gene to outside databases

Previous GC identifers: GC05M055398 GC05M056665 GC05M055207 GC05M055252 GC05M055272 GC05M052204


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL6ST Gene:
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6),
ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein
functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the
binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi
sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein.
Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis.
Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene
has been identified on chromosome 17. (provided by RefSeq, Jul 2010)

GeneCards Summary for IL6ST Gene: 
IL6ST (interleukin 6 signal transducer (gp130, oncostatin M receptor)) is a protein-coding gene. Diseases associated with IL6ST include conjunctival disease, and cold-induced sweating syndrome, and among its related super-pathways are STAT3 Pathway and G-protein signaling Ras family GTPases in kinase cascades (scheme). GO annotations related to this gene include interleukin-6 receptor binding and protein homodimerization activity. An important paralog of this gene is OSMR.

UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189
Function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can
utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the
formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in
embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling
events

Gene Wiki entry for IL6ST (Glycoprotein 130) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL6ST gene promoter:
         STAT1   FOXF2   MEF-2   E4BP4   LCR-F1   GATA-1   STAT3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL6ST promoter sequence
   Search SABiosciences Chromatin IP Primers for IL6ST

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL6ST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

IL6ST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL6ST gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M055230:  view genomic region     (about GC identifiers)

Start:
55,230,923 bp from pter      End:
55,290,821 bp from pter
Size:
59,899 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189 (See protein sequence)
Recommended Name: Interleukin-6 receptor subunit beta precursor  
Size: 918 amino acids; 103537 Da
Subunit: Interacts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM
receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer
binds two molecules of herpes virus IL6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST.
Interacts with HCK
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
6/9 PDB 3D structures from and Proteopedia for IL6ST (see all 9):
1BJ8 (3D)        1BQU (3D)        1I1R (3D)        1N2Q (3D)        1P9M (3D)        1PVH (3D)    
Secondary accessions: A0N0L4 Q5FC04 Q9UQ41
Alternative splicing: 3 isoforms:  P40189-1   P40189-2   P40189-3   

Explore the universe of human proteins at neXtProt for IL6ST: NX_P40189

Explore proteomics data for IL6ST at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation of Ser-782 down-regulates cell surface expression
  • UniProtKB: Heavily N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P40189

  • IL6ST Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL6ST Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001177910.1  NP_002175.2  NP_786943.1  

    ENSEMBL proteins: 
     ENSP00000370698   ENSP00000426224   ENSP00000462158   ENSP00000370694   ENSP00000370693  
     ENSP00000370686   ENSP00000435399   ENSP00000338799   ENSP00000370687   ENSP00000444456  
     ENSP00000463896  
    Reactome Protein details: P40189
    Human Recombinant Protein Products for IL6ST: 
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    R&D Systems Recombinant & Natural Proteins for IL6ST (gp130)
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    Novus Biologicals IL6ST Proteins
    Novus Biologicals IL6ST Lysate
    Sino Biological Recombinant Protein for IL6ST
    Sino Biological Cell Lysate for IL6ST 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA8353278
    GO:0005886plasma membrane TAS--
    GO:0005896interleukin-6 receptor complex IDA12829785
    GO:0005900oncostatin-M receptor complex IDA8999038

    IL6ST for ontologies           About GeneDecksing



    IL6ST Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL6ST
    R&D Systems Antibodies for IL6ST (gp130)
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    Novus Biologicals IL6ST Antibodies
    Abcam antibodies for IL6ST
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    ThermoFisher Antibodies for IL6ST
    LSBio Antibodies in human, mouse, rat for IL6ST 

    Assay Products for IL6ST: 
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    R&D Systems ELISAs for IL6ST (gp130)         (see all)
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing
    CD: CD molecules
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin-6 receptor, β subunit 
    IL-6 receptor family

    5 InterPro protein domains:
     IPR015321 IL6_recept-bd
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR010457 IgC2-like_lig-bd
     IPR003529 Hematopoietin_rcpt_Gp130_CS

    Graphical View of Domain Structure for InterPro Entry P40189

    ProtoNet protein and cluster: P40189

    3 Blocks protein domains:
    IPB003529 Long hematopoietin receptor
    IPB003962 Fibronectin type III repeat signature
    IPB010457 Ig-like C2-type


    UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Domain: The box 1 motif is required for JAK interaction and/or activation
    Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily
    Similarity: Contains 5 fibronectin type-III domains
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    IL6ST for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL6RB_HUMAN, P40189
    Function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can
    utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the
    formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in
    embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling
    events
    Induction: LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor

         Genatlas biochemistry entry for IL6ST:
    interleukin 6,signal transducer (GP130),needed for IL6R activity and signal transduction of the IL-6 related
    cytokines,mediated by JAK kinases,ubiquitously expressed,with a membrane bound and an alternatively spliced
    secreted form

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004897ciliary neurotrophic factor receptor activity IDA12643274
    GO:0004915contributes to interleukin-6 receptor activity IGI12643274
    GO:0004921interleukin-11 receptor activity IEA--
    GO:0004923contributes to leukemia inhibitory factor receptor activity IGI12643274
    GO:0004924contributes to oncostatin-M receptor activity IDA8999038
         
    IL6ST for ontologies           About GeneDecksing


    Phenotypes:
         15/19 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Il6st) (see all 19):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  liver/biliary system  mortality/aging  nervous system  normal 

    IL6ST for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL6ST: Il6sttm1.1Wme Il6sttm1Kish Il6sttm1Ern Il6sttm3Thir

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL6ST 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL6ST

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL6ST 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL6ST 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL6ST
    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate IL6ST (see all 88):
    hsa-miR-548j hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-188-5p hsa-miR-4272 hsa-miR-106a hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL6ST 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL6ST
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL6ST

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of IL6ST

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for IL6ST
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IL6ST (NM_002184)
    Sino Biological Human cDNA Clone for IL6ST
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6ST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6ST
    Sirion Biotech Customized lentivirus for stable overexpression of IL6ST 
                         Customized lentivirus expression plasmids for stable overexpression of IL6ST 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6ST


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL6ST About   (see all 25)                                                                                              See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    IL-6 Pathway0.61
    Cytokine-cytokine receptor interaction0.43
    2G-protein signaling Ras family GTPases in kinase cascades (scheme)
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Oncostatin M Signaling Pathway0.37
    3IL27-mediated signaling events
    IL27-mediated signaling events0.38
    Th1 Differentiation0.38
    4Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response Oncostatin M signaling via JAK-Stat in human cells0.30
    Interleukin-6 signaling0.30
    5Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF0.72
    Cytokine production by Th17 cells in CF (Mouse model)0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for IL6ST (see all 6)
        Transcription Androgen Receptor nuclear signaling
    Cell adhesion PLAU signaling
    Immune response IL-6 signaling pathway
    Immune response Oncostatin M signaling via MAPK in human cells
    Development CNTF receptor signaling

    3 R&D Systems Pathways for IL6ST
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Th17 Differentiation

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL6ST (see all 6)
        OSM Pathway
    CNTF Signaling
    ERK5 Signaling
    NFAT and Cardiac Hypertrophy
    Signaling Involved in Cardiac Hypertrophy

    1 Cell Signaling Technology (CST) Pathway for IL6ST
        Jak/Stat Pathway

    5/9 GeneGo (Thomson Reuters) Pathways for IL6ST (see all 9)
        Immune response IL-6 signaling pathway
    Transcription Androgen Receptor nuclear signaling
    Development CNTF receptor signaling
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Mucin expression in CF via IL-6, IL-17 signaling pathways

    5/8 BioSystems Pathways for IL6ST (see all 8)
        MicroRNAs in cardiomyocyte hypertrophy
    Senescence and Autophagy
    Adipogenesis
    Oncostatin M Signaling Pathway
    IL-6 Signaling Pathway


    4        Reactome Pathways for IL6ST
        Interleukin-6 signaling
    Cytokine Signaling in Immune system
    Signaling by Interleukins
    Immune System


    3         Kegg Pathways  (Kegg details for IL6ST):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Viral carcinogenesis


    IL6ST for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL6ST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/76 Interacting proteins for IL6ST (P401891, 2, 3 ENSP000003387994) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT1P422242, 3, ENSP000003543944MINT-8030726 MINT-8028344 MINT-8028329 I2D: score=1 STRING: ENSP00000354394
    CNTFP264412, 3, ENSP000003553704MINT-62479 MINT-62480 I2D: score=2 STRING: ENSP00000355370
    OSMP137252, 3, ENSP000002157814MINT-62481 MINT-62482 I2D: score=2 STRING: ENSP00000215781
    LIFP150182, 3, ENSP000002490754MINT-62483 I2D: score=5 STRING: ENSP00000249075
    IL6RP088873, ENSP000003574704I2D: score=5 STRING: ENSP00000357470
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002675positive regulation of acute inflammatory response IC8999038
    GO:0002821positive regulation of adaptive immune response IC14764690
    GO:0005977glycogen metabolic process IEA--
    GO:0007165signal transduction ----
    GO:0008284positive regulation of cell proliferation IGI8999038

    IL6ST for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL6ST for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL6ST (IL6RB)

    10/30 Novoseek inferred chemical compound relationships for IL6ST gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 99.3 2328 19330911 (10), 18519587 (10), 12691915 (10), 7812050 (9) (see all 99)
    tyrosine 64.4 106 7538109 (5), 10623831 (4), 10068651 (3), 8174677 (2) (see all 68)
    phosphotyrosine 30.4 2 10946280 (1), 7812050 (1)
    dexamethasone 17.4 6 8547658 (1), 8977259 (1), 7861551 (1), 1337986 (1) (see all 5)
    ifn-alpha 15.7 3 12482347 (3)
    retinoic acid 11.8 12 10695998 (3), 10381520 (2), 7949175 (2), 8547658 (1) (see all 6)
    serine 10.1 5 10811661 (2), 8621406 (1), 8511589 (1), 7624343 (1)
    ang ii 10 1 10720495 (1)
    oligonucleotide 7.68 4 12513832 (2), 11482910 (1), 12695539 (1)
    threonine 4.72 2 7624343 (1), 10811661 (1)

    Search CenterWatch for drugs/clinical trials and news about IL6ST / IL6RB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL6ST gene (3 alternative transcripts): 
    NM_001190981.1  NM_002184.3  NM_175767.2  

    Unigene Clusters for IL6ST:

    Interleukin 6 signal transducer (gp130, oncostatin M receptor)
    Hs.532082  [show with all ESTs], Hs.706627
    Unigene Representative Sequences: NM_002184, AB102803
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381298(uc003jqp.3 uc010iwd.3 uc011cqk.2 uc003jqq.3 uc003jqr.3 uc010iwb.3)
    ENST00000503773 ENST00000502326 ENST00000381294 ENST00000523039 ENST00000583149(uc010iwe.1)
    ENST00000381293 ENST00000381286 ENST00000522633(uc010iwf.1) ENST00000423954
    ENST00000506241 ENST00000577363 ENST00000336909 ENST00000381287 ENST00000536319
    ENST00000396816
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): IL6ST (NM_002184)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6ST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6ST
    Sirion Biotech Customized lentivirus for stable overexpression of IL6ST 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL6ST

    Additional mRNA sequence: AB102803.1 

    14 DOTS entries:

    DT.95072775  DT.118660  DT.101977480  DT.95072808  DT.99957684  DT.100779983  DT.100779982  DT.120797204 
    DT.92422787  DT.75126328  DT.95072782  DT.120797188  DT.121007629  DT.97768242 

    24/410 AceView cDNA sequences (see all 410):

    AA033718 BF590236 H85457 AA043274 AI288595 AW237619 AA909654 BE502242 
    BQ005125 BU751810 AA406546 AI769984 CA442319 T40054 BM508172 AL598252 
    BU620372 BX503730 AA890646 BM969205 AA099279 CF529976 NM_002184 BM985051 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IL6ST    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                                                                
    SP2:                                                        -                                       
    SP3:                                            -                                                   


    ECgene alternative splicing isoforms for IL6ST

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL6ST expression in normal human tissues (normalized intensities)      IL6ST embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATGCTAA
    IL6ST Expression
    About this image


    IL6ST expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             T Helper Cells Thymus
             cd4+ t cell   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow Stromal Cells Bone Marrow
             Bone marrow-derived mesenchymal stem cells
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatoblasts Liver Bud
     
     Uterus (Reproductive System)
             endometrium   

    See IL6ST Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL6ST

    SOURCE GeneReport for Unigene clusters: Hs.532082 Hs.706627

    UniProtKB/Swiss-Prot: IL6RB_HUMAN, P40189
    Tissue specificity: Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive
    cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL6ST (see all 12): 
              Multiple Sclerosis in human mouse rat
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL6ST
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6ST

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL6ST gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il6st1 , 5 interleukin 6 signal transducer1, 5 78.68(n)1
    77.69(a)1
      13 (63.73 cM)5
    161951  NM_010560.31  NP_034690.31 
     1124750085 
    chicken
    (Gallus gallus)
    Aves IL6ST1 interleukin 6 signal transducer (gp130, oncostatin more 67.59(n)
    60.89(a)
      395684  NM_204871.1  NP_990202.1 
    lizard
    (Anolis carolinensis)
    Reptilia IL6ST6
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    55(a)
    25(a)
    (see all 3)
    1 ↔ 1
    possible ortholog
    (see all 3)
    2(2259922-2288478)
    AAWZ02039210(3284-8959)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF041846.12   -- 72.95(n)    AF041846.1 
    zebrafish
    (Danio rerio)
    Actinopterygii il6st1 interleukin 6 signal transducer 50.02(n)
    39.97(a)
      100006778  NM_001113504.1  NP_001106976.1 


    ENSEMBL Gene Tree for IL6ST (if available)
    TreeFam Gene Tree for IL6ST (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL6ST gene
    OSMR2  CSF3R2  IL31RA2  LIFR2  IL12RB22  
    2 SIMAP similar genes for IL6ST using alignment to 8 protein entries:     IL6RB_HUMAN (see all proteins):
    gp130    IL23R

    IL6ST for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IL6ST
    PGOHUM00000237232


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1226 SNPs in IL6ST are shown (see all 1226)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361654
    A colorectal cancer sample4--see VAR_0361652 T I mis40--------
    rs1860992521,2
    C--55230635(+) CTACAA/GGCAAG 3 -- ds50010--------
    rs1922562021,2
    --55230664(+) TCCTAC/GGGGGA 3 -- ds50010--------
    rs731204711,2
    C,F--55230800(+) TGAACC/TAGCAC 3 -- ds50011Minor allele frequency- T:0.50WA 2
    rs623638651,2
    C,F--55230880(+) CCAGGG/CCTAAT 3 -- ds50019Minor allele frequency- C:0.10NA WA CSA EA 370
    rs759769881,2
    C--55230929(+) TTTGGG/TTTTTT 3 -- ut310--------
    rs64503561,2
    C,A--55231202(+) GCTTCG/TTATCT 3 -- ut31 ese32Minor allele frequency- T:0.07CSA WA 120
    rs716222021,2
    C--55231266(+) AATTTG/TGAGTT 3 -- ut312Minor allele frequency- T:0.25NA 4
    rs106280131,2
    C--55231311(+) CTTTT-/AG    
       C
    /CAG
    CTATG
    6 -- cds11CSA 2
    rs1827638281,2
    --55231311(+) ACTTTG/TCTATG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for IL6ST (55230923 - 55290821 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IL6ST:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv270483CNV Insertion20981092
    esv273490CNV Insertion20981092
    nsv830307CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600694    OMIM disorders: --

    20/87 diseases for IL6ST (see all 87):    About MalaCards
    conjunctival disease    cold-induced sweating syndrome    kaposi's sarcoma    breast carcinoma in situ
    hepatocellular adenoma    preterm premature rupture of the membranes    plasmacytoma    prolactinoma
    sleep disorder    plasmodium falciparum malaria    rheumatoid arthritis    myeloma
    aggressive periodontitis    essential thrombocythemia    status epilepticus    congestive heart failure
    arthritis    chronic fatigue syndrome    hyperandrogenism    sarcoma


    IL6ST for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/45 Novoseek inferred disease relationships for IL6ST gene (see all 45)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 81 143 11721361 (3), 8145045 (2), 9630704 (2), 7919380 (2) (see all 99)
    myeloma 70.6 27 12646637 (3), 14637393 (3), 12515619 (3), 7713920 (2) (see all 15)
    response acute phase 49 3 8662795 (1), 12830005 (1), 9404669 (1)
    plasmacytoma 43.7 4 8145046 (2), 8137932 (1)
    choriocarcinoma 30.6 2 8583009 (1), 15373762 (1)
    inflammation 28.2 4 15837947 (1), 7538109 (1), 17664290 (1), 17903270 (1)
    necrosis 22.1 8 8720493 (2), 19631179 (1), 8547494 (1), 11171064 (1) (see all 7)
    rheumatoid arthritis 18.3 10 16646038 (2), 10880057 (1), 12510348 (1)
    herpes 16.1 1 10848977 (1)
    tumors 14.1 17 8720493 (2), 9951579 (2), 10480339 (1), 18317962 (1) (see all 15)

    Genetic Association Database (GAD): IL6ST
    Human Genome Epidemiology (HuGE) Navigator: IL6ST (23 documents)

    Export disorders for IL6ST gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL6ST gene, integrated from 9 sources (see all 616):
    (articles sorted by number of sources associating them with IL6ST)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of an IL-6 signal transducer, gp130. (PubMed id 2261637)1, 2, 3, 9 Hibi M.... Kishimoto T. (1990)
    2. Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis. (PubMed id 10880057)1, 2, 9 Tanaka M.... Nakao K. (2000)
    3. Phosphorylation of human gp130 at Ser-782 adjacent to the di-leucine internalization motif. Effects on expression and signaling. (PubMed id 10811661)1, 2, 9 Gibson R.M....Nathanson N.M. (2000)
    4. Structure of an extracellular gp130 cytokine receptor signaling complex. (PubMed id 11251120)1, 2, 9 Chow D.-C.... Garcia K.C. (2001)
    5. Crystal structure of a cytokine-binding region of gp130. (PubMed id 9501088)1, 2, 9 Bravo J.... Jones E.Y. (1998)
    6. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. (PubMed id 8999038)1, 2, 9 Mosley B....Cosman D. (1996)
    7. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    8. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    9. Genome-wide association study meta-analysis identifie s seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1, 4 Stahl E.A....Plenge R.M. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3572 HGNC: 6021 AceView: IL6ST Ensembl:ENSG00000134352 euGenes: HUgn3572
    ECgene: IL6ST Kegg: 3572 H-InvDB: IL6ST

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL6ST Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL6ST Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL6ST gene:
    Search GeneIP for patents involving IL6ST

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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