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Aliases for IL6R Gene

Aliases for IL6R Gene

  • Interleukin 6 Receptor 2 3
  • IL-6 Receptor Subunit Alpha 3 4
  • Membrane Glycoprotein 80 3 4
  • CD126 Antigen 3 4
  • IL-6R 1 3 4
  • IL-6RA 3 4
  • Gp80 3 4
  • IL-6R Subunit Alpha 4
  • IL-6R-Alpha 4
  • IL-6R-1 3
  • CD126 3
  • IL6RA 3
  • IL6RQ 3
  • IL6Q 3

External Ids for IL6R Gene

Previous GeneCards Identifiers for IL6R Gene

  • GC01P152194
  • GC01P150108
  • GC01P151152
  • GC01P151594
  • GC01P151190
  • GC01P152644
  • GC01P125740

Summaries for IL6R Gene

Entrez Gene Summary for IL6R Gene

  • This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]

GeneCards Summary for IL6R Gene

IL6R (Interleukin 6 Receptor) is a Protein Coding gene. Diseases associated with IL6R include multicentric castleman disease and castleman disease. Among its related pathways are PI3K-Akt signaling pathway and Immune System. GO annotations related to this gene include protein homodimerization activity and interleukin-6 receptor binding. An important paralog of this gene is IL11RA.

UniProtKB/Swiss-Prot for IL6R Gene

  • Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis

  • Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity

Gene Wiki entry for IL6R Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL6R Gene

Genomics for IL6R Gene

Regulatory Elements for IL6R Gene

Transcription factor binding sites by QIAGEN in the IL6R gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IL6R Gene

Chromosome:
1
Start:
154,405,193 bp from pter
End:
154,469,450 bp from pter
Size:
64,258 bases
Orientation:
Plus strand

Genomic View for IL6R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL6R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL6R Gene

Proteins for IL6R Gene

  • Protein details for IL6R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08887-IL6RA_HUMAN
    Recommended name:
    Interleukin-6 receptor subunit alpha
    Protein Accession:
    P08887
    Secondary Accessions:
    • A8KAE8
    • B2R6V4
    • Q16202
    • Q53EQ7
    • Q5FWG2
    • Q5VZ23

    Protein attributes for IL6R Gene

    Size:
    468 amino acids
    Molecular mass:
    51548 Da
    Quaternary structure:
    • Hexamer of two molecules each of IL6, IL6R and IL6ST

    Three dimensional structures from OCA and Proteopedia for IL6R Gene

    Alternative splice isoforms for IL6R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL6R Gene

Proteomics data for IL6R Gene at MOPED

Post-translational modifications for IL6R Gene

  • A short soluble form may also be released from the membrane by proteolysis
  • Glycosylation at Asn 55, Asn 93, and Asn 221
  • Modification sites at PhosphoSitePlus

Other Protein References for IL6R Gene

Antibody Products

No data available for DME Specific Peptides for IL6R Gene

Domains & Families for IL6R Gene

Suggested Antigen Peptide Sequences for IL6R Gene

Graphical View of Domain Structure for InterPro Entry

P08887

UniProtKB/Swiss-Prot:

IL6RA_HUMAN :
  • The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain
  • Belongs to the type I cytokine receptor family. Type 3 subfamily.
Domain:
  • The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding
  • Contains 2 fibronectin type-III domains.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Family:
  • Belongs to the type I cytokine receptor family. Type 3 subfamily.
genes like me logo Genes that share domains with IL6R: view

Function for IL6R Gene

Molecular function for IL6R Gene

GENATLAS Biochemistry:
interleukin 6,receptor,alpha subunit,low activity receptor,heterodimerizing with IL6ST
UniProtKB/Swiss-Prot Function:
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis
UniProtKB/Swiss-Prot Function:
Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity

Gene Ontology (GO) - Molecular Function for IL6R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity --
GO:0004897 contributes_to ciliary neurotrophic factor receptor activity IMP 12643274
GO:0004915 contributes_to interleukin-6 receptor activity IDA 2261637
GO:0005138 contributes_to interleukin-6 receptor binding IPI 12829785
GO:0005515 protein binding IPI 11238858
genes like me logo Genes that share ontologies with IL6R: view
genes like me logo Genes that share phenotypes with IL6R: view

Animal Models for IL6R Gene

MGI Knock Outs for IL6R:

Animal Model Products

miRNA for IL6R Gene

miRTarBase miRNAs that target IL6R

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL6R

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL6R Gene

Localization for IL6R Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL6R Gene

Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL6R Gene COMPARTMENTS Subcellular localization image for IL6R gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IL6R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0005896 interleukin-6 receptor complex IDA 2261637
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with IL6R: view

Pathways & Interactions for IL6R Gene

genes like me logo Genes that share pathways with IL6R: view

PCR Array Products

SIGNOR curated interactions for IL6R Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL6R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002384 hepatic immune response TAS 12832423
GO:0002446 neutrophil mediated immunity TAS 16034137
GO:0002548 monocyte chemotaxis IC 10510402
GO:0002690 positive regulation of leukocyte chemotaxis TAS 15100312
GO:0006953 acute-phase response TAS 12832423
genes like me logo Genes that share ontologies with IL6R: view

Drugs & Compounds for IL6R Gene

(25) Drugs for IL6R Gene - From: NovoSeek, DGIdb, PharmGKB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tocilizumab Approved Pharma immunotherapy, antibody, Target Immunotherapies 0
Dexamethasone Approved, Investigational Pharma Agonist 1806
Estradiol Approved, Investigational Pharma Sex hormone 1057
Ethanol Approved Pharma 1708
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1387

(25) Additional Compounds for IL6R Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-O-Tetradecanoylphorbol 13-acetate
AF 10
Agarose
butyrate
Creatinine
  • 1-Methylglycocyamidine
  • 1-Methylhydantoin-2-imide
  • 2-Amino-1-methyl-1,5-dihydroimidazol-4-one
  • 2-Amino-1-methylimidazolin-4-one
  • Creatine anhydride
60-27-5
genes like me logo Genes that share compounds with IL6R: view

Transcripts for IL6R Gene

Unigene Clusters for IL6R Gene

Interleukin 6 receptor:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL6R

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL6R Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: - -
SP3:
SP4: - -
SP5: -

Relevant External Links for IL6R Gene

GeneLoc Exon Structure for
IL6R
ECgene alternative splicing isoforms for
IL6R

Expression for IL6R Gene

mRNA expression in normal human tissues for IL6R Gene

mRNA differential expression in normal tissues according to GTEx for IL6R Gene

This gene is overexpressed in Whole Blood (x11.4) and Muscle - Skeletal (x9.3).

Protein differential expression in normal tissues from HIPED for IL6R Gene

This gene is overexpressed in Nasal epithelium (56.1) and Serum (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL6R Gene



SOURCE GeneReport for Unigene cluster for IL6R Gene Hs.135087

mRNA Expression by UniProt/SwissProt for IL6R Gene

P08887-IL6RA_HUMAN
Tissue specificity: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum
genes like me logo Genes that share expression patterns with IL6R: view

Protein tissue co-expression partners for IL6R Gene

Primer Products

In Situ Assay Products

Orthologs for IL6R Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL6R Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL6R 35
  • 81.54 (n)
  • 74.35 (a)
IL6R 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL6R 35
  • 79.79 (n)
  • 74.5 (a)
IL6R 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il6ra 35
  • 68.37 (n)
  • 55.35 (a)
Il6ra 16
Il6ra 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL6R 35
  • 99.36 (n)
  • 99.57 (a)
IL6R 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il6r 35
  • 69.2 (n)
  • 55.99 (a)
oppossum
(Monodelphis domestica)
Mammalia IL6R 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il6r 35
  • 45.02 (n)
  • 35.57 (a)
zebrafish
(Danio rerio)
Actinopterygii il6r 35
  • 43.38 (n)
  • 32.6 (a)
il6r 36
  • 20 (a)
OneToOne
Species with no ortholog for IL6R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL6R Gene

ENSEMBL:
Gene Tree for IL6R (if available)
TreeFam:
Gene Tree for IL6R (if available)

Paralogs for IL6R Gene

Paralogs for IL6R Gene

Pseudogenes.org Pseudogenes for IL6R Gene

genes like me logo Genes that share paralogs with IL6R: view

Variants for IL6R Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IL6R Gene

P08887-IL6RA_HUMAN
Genetic variations in IL6R define the IL6 serum level quantitative trait locus [MIM:614752]

Sequence variations from dbSNP and Humsavar for IL6R Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1138004 -- 154,465,962(+) CAGTT(C/G)AAAAA utr-variant-3-prime
rs1138006 -- 154,466,001(+) AGTAT(C/G)TCAGG utr-variant-3-prime
rs1138007 -- 154,466,591(+) catgg(A/T)ggccc utr-variant-3-prime
rs2228144 -- 154,429,203(+) GTGGC(A/G)AGAGG synonymous-codon, reference
rs2228145 other, - 154,454,494(+) GCAAG(A/C/T)TTCTT reference, missense, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL6R Gene

Variant ID Type Subtype PubMed ID
nsv521887 CNV Gain 19592680

Variation tolerance for IL6R Gene

Residual Variation Intolerance Score: 35.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.11; 80.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL6R Gene

HapMap Linkage Disequilibrium report
IL6R
Human Gene Mutation Database (HGMD)
IL6R

Disorders for IL6R Gene

MalaCards: The human disease database

(16) MalaCards diseases for IL6R Gene - From: Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
multicentric castleman disease
  • idiopathic multicentric castleman's disease
castleman disease
  • angiofollicular lymph hyperplasia
pycnodysostosis
  • pknd
cerebral meningioma
  • meningioma of cerebrum
myeloma
  • multiple myeloma
- elite association
Search IL6R in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL6R

Genetic Association Database (GAD)
IL6R
Human Genome Epidemiology (HuGE) Navigator
IL6R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL6R
genes like me logo Genes that share disorders with IL6R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL6R Gene

Publications for IL6R Gene

  1. ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase. (PMID: 20026129) Chalaris A. … Scheller J. (Biochim. Biophys. Acta 2010) 23 67
  2. Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study. (PMID: 20112381) Illei G.G. … Lipsky P.E. (Arthritis Rheum. 2010) 23 67
  3. Evidence for altered activity of the IL-6 pathway in chronic rhinosinusitis with nasal polyps. (PMID: 20159251) Peters A.T. … Schleimer R.P. (J. Allergy Clin. Immunol. 2010) 23 67
  4. Overproduced interleukin 6 decreases blood lipid levels via upregulation of very-low-density lipoprotein receptor. (PMID: 19433409) Hashizume M. … Mihara M. (Ann. Rheum. Dis. 2010) 23 67
  5. The addition of tocilizumab to DMARD therapy for rheumatoid arthritis: a meta-analysis of randomized controlled trials. (PMID: 19936725) An M.M. … Jiang Y.Y. (Eur. J. Clin. Pharmacol. 2010) 23 67

Products for IL6R Gene

Sources for IL6R Gene

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