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IL6R Gene

protein-coding   GIFtS: 70
GCID: GC01P154377

Interleukin 6 Receptor

  See IL6R-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 6 Receptor1 2     IL6RQ2 5
Membrane Glycoprotein 802 3     CD1262
IL-6RA2 3     IL-6R-12
CD126 Antigen2 3     IL6RA2
gp802 3     Interleukin-6 Receptor Subunit Alpha2
IL-6 Receptor Subunit Alpha2 3     IL-6R-alpha3
IL-6R 12 3     IL-6R Subunit Alpha3
IL6Q2 5     

External Ids:    HGNC: 60191   Entrez Gene: 35702   Ensembl: ENSG000001607127   OMIM: 1478805   UniProtKB: P088873   

Export aliases for IL6R gene to outside databases

Previous GC identifers: GC01P152194 GC01P150108 GC01P151152 GC01P151594 GC01P151190 GC01P152644 GC01P125740


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL6R Gene:
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic
cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The
IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer
(IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6
and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune
diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been
reported. A pseudogene of this gene is found on chromosome 9.(provided by RefSeq, May 2011)

GeneCards Summary for IL6R Gene:
IL6R (interleukin 6 receptor) is a protein-coding gene. Diseases associated with IL6R include nodular goiter, and pleomorphic malignant fibrous histiocytoma. GO annotations related to this gene include interleukin-6 receptor binding and protein homodimerization activity. An important paralog of this gene is IL11RA.

UniProtKB/Swiss-Prot: IL6RA_HUMAN, P08887
Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal.
Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune
response, acute-phase reactions and hematopoiesis
Function: Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity

Gene Wiki entry for IL6R (Interleukin-6 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL6R gene promoter:
         GATA-3   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL6R promoter sequence
   Search Chromatin IP Primers for IL6R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL6R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

IL6R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL6R gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P154377:  view genomic region     (about GC identifiers)

Start:
154,377,669 bp from pter      End:
154,441,926 bp from pter
Size:
64,258 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IL6RA_HUMAN, P08887 (See protein sequence)
Recommended Name: Interleukin-6 receptor subunit alpha precursor  
Size: 468 amino acids; 51548 Da
Subunit: Hexamer of two molecules each of IL6, IL6R and IL6ST
4 PDB 3D structures from and Proteopedia for IL6R:
1N26 (3D)        1N2Q (3D)        1P9M (3D)        2ARW (3D)    
Secondary accessions: A8KAE8 B2R6V4 Q16202 Q53EQ7 Q5FWG2 Q5VZ23
Alternative splicing: 2 isoforms:  P08887-1   P08887-2   

Explore the universe of human proteins at neXtProt for IL6R: NX_P08887

Explore proteomics data for IL6R at MOPED

Post-translational modifications: 

  • A short soluble form may also be released from the membrane by proteolysis1
  • Glycosylation2 at Asn55, Asn93, Asn221
  • Modification sites at PhosphoSitePlus

  • See IL6R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000556.1  NP_001193795.1  NP_852004.1  

    ENSEMBL proteins: 
     ENSP00000357470   ENSP00000340589   ENSP00000423184   ENSP00000423668   ENSP00000423036  
    Reactome Protein details: P08887

    IL6R Human Recombinant Protein Products:

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    OriGene Purified Proteins for IL6R
    OriGene Protein Over-expression Lysate for IL6R
    OriGene MassSpec for IL6R
    OriGene Custom Protein Services for IL6R
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    Novus Biologicals IL6R Proteins
    Novus Biologicals IL6R Lysates
    Sino Biological Recombinant Protein for IL6R
    Sino Biological Cell Lysate for IL6R
    ProSpec Recombinant Protein for IL6R
    Cloud-Clone Corp. Proteins for IL6R

     
    Search eBioscience for Proteins for IL6R 

     
    antibodies-online proteins for IL6R (42 products) 

     
    antibodies-online peptides for IL6R

    IL6R Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL6R
    R&D Systems Antibodies for IL6R (IL-6 R alpha)
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    Novus Biologicals IL6R Antibodies
    Abcam antibodies for IL6R
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    antibodies-online antibodies for IL6R (14 products) 

    IL6R Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for IL6R (IL-6 R alpha)         (see all)
    GenScript Custom Assay Services for IL6R
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL6R
    Cloud-Clone Corp. CLIAs for IL6R
    eBioscience ELISAs for IL6R: (see all 3
                        Human sIL-6R Instant ELISA 128 tests
    antibodies-online kits for IL6R (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin-6 receptor, alpha subunit
    IL-6 receptor family

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR015321 IL-6_rcpt_alpha-bd
     IPR003961 Fibronectin_type3
     IPR003530 Hematopoietin_rcpt_L_F3_CS
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P08887

    ProtoNet protein and cluster: P08887

    2 Blocks protein domains:
    IPB003530 Long hematopoietin receptor
    IPB003598 Immunoglobulin C-2 type


    UniProtKB/Swiss-Prot: IL6RA_HUMAN, P08887
    Domain: The two fibronectin type-III-like domains, contained in the N-terminal part, form together a
    cytokine-binding domain
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Similarity: Belongs to the type I cytokine receptor family. Type 3 subfamily
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    Find genes that share domains with IL6R           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL6RA_HUMAN, P08887
    Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal.
    Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune
    response, acute-phase reactions and hematopoiesis
    Function: Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity

         Genatlas biochemistry entry for IL6R:
    interleukin 6,receptor,alpha subunit,low activity receptor,heterodimerizing with IL6ST

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004897contributes to ciliary neurotrophic factor receptor activity IMP12643274
    GO:0004915contributes to interleukin-6 receptor activity IDA2261637
    GO:0005138contributes to interleukin-6 receptor binding IPI12829785
    GO:0005515protein binding IPI11238858
    GO:0019899enzyme binding IPI12748171
         
    Find genes that share ontologies with IL6R           About GenesLikeMe


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Il6ra):
     adipose tissue  behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     normal  tumorigenesis 

    Find genes that share phenotypes with IL6R           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL6R: Il6ratm1.2Jcbr Il6ratm1.2Drew

       genOway: Develop your customized and physiologically relevant rodent model for IL6R

    miRNA
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    miRTarBase miRNAs that target IL6R:
    hsa-mir-124-3p (MIRT006541), hsa-mir-98-5p (MIRT027423), hsa-mir-23a-3p (MIRT005528)

    Block miRNA regulation of human, mouse, rat IL6R using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL6R (see all 66):
    hsa-miR-3916 hsa-miR-629* hsa-miR-4324 hsa-miR-34c-5p hsa-miR-130a* hsa-miR-23c hsa-let-7i hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidIL6R 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL6R

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): IL6R (NM_000565)
    Sino Biological Human cDNA Clone for IL6R
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6R

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6R

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-11611 VA6-12558) for IL6R 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL6RA_HUMAN, P08887: Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein
    IL6RA_HUMAN, P08887: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA12419823
    GO:0005886plasma membrane TAS--
    GO:0005896interleukin-6 receptor complex IDA12829785
    GO:0009986cell surface IEA--

    Find genes that share ontologies with IL6R           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL6R About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    IL-6 Pathway0.61
    Glucocorticoid Receptor Signaling0.43
    PGC1Alpha Pathway0.51
    Cytokine-cytokine receptor interaction0.43
    STAT3 Pathway0.47
    2TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4Cytokine production by Th17 cells in CF
    Cytokine production by Th17 cells in CF0.72
    Cytokine production by Th17 cells in CF Mouse model 0.72
    5Th17 Differentiation
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47
    Th17 Differentiation0.47


    Find genes that share SuperPaths with IL6R           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IL6R
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th17 Differentiation

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL6R (see all 14)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Glucocorticoid Receptor Signaling
    JAK-STAT Pathway

    5 GeneGo (Thomson Reuters) Pathways for IL6R
        Immune response IL-6 signaling pathway
    Transcription Androgen Receptor nuclear signaling
    Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF
    Mucin expression in CF via IL-6, IL-17 signaling pathways

    4 BioSystems Pathways for IL6R
        Senescence and Autophagy
    SIDS Susceptibility Pathways
    IL-6 Signaling Pathway
    IL6-mediated signaling events


    1 Reactome Pathway for IL6R
        Interleukin-6 signaling


    Selected Kegg Pathways  (Kegg details for IL6R) (see all 6):
        Cytokine-cytokine receptor interaction
    HIF-1 signaling pathway
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway
    Hematopoietic cell lineage

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL6R (see all 10): 
              Interferons & Receptors in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th17 Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL6R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL6R (P088871, 2, 3 ENSP000003574704) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL6P052311, 3, ENSP000002587434EBI-299383,EBI-720533 I2D: score=5 STRING: ENSP00000258743
    JAK1P234582, 3, ENSP000003432044MINT-15143 I2D: score=1 STRING: ENSP00000343204
    WWP2O003083, ENSP000003482834I2D: score=1 STRING: ENSP00000348283
    IL6STP401893, ENSP000003387994I2D: score=5 STRING: ENSP00000338799
    CNTFP264413, ENSP000003553704I2D: score=2 STRING: ENSP00000355370
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002384hepatic immune response TAS12832423
    GO:0002446neutrophil mediated immunity IC16034137
    GO:0002548monocyte chemotaxis IC10510402
    GO:0002690positive regulation of leukocyte chemotaxis TAS15100312
    GO:0006953acute-phase response TAS12832423

    Find genes that share ontologies with IL6R           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL6R (IL6RA)

    2 DrugBank Compounds for IL6R    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TocilizumabAtlizumab (see all 4)375823-41-9targetantibody16899109
    Alpha-D-Mannose-- 3458-28-4target----

    Selected Novoseek inferred chemical compound relationships for IL6R gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 97 450 11238858 (6), 10813718 (6), 8720493 (5), 11884403 (5) (see all 99)
    tocilizumab 91.6 56 18653811 (5), 19365268 (2), 18358926 (2), 18664393 (2) (see all 32)
    tapi 64.4 4 7594530 (3)
    af 10 42.8 6 7963520 (3), 2033252 (3)
    dexamethasone 37.7 29 9734662 (2), 7595216 (2), 8977259 (2), 15930364 (1) (see all 14)
    retinoic acid 29 27 2033252 (6), 10381520 (5), 7949175 (2), 9734662 (1) (see all 11)
    rottlerin 27.8 2 11485567 (1), 12832423 (1)
    il 10 24.4 1 9083231 (1)
    fibrinogen 23.4 4 9722935 (1), 19739579 (1), 11282562 (1), 18496641 (1)
    ifn-alpha 23 3 11740974 (1), 12482347 (1)



    Find genes that share compounds with IL6R           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL6R gene (3 alternative transcripts): 
    NM_000565.3  NM_001206866.1  NM_181359.2  

    Unigene Cluster for IL6R:

    Interleukin 6 receptor
    Hs.135087  [show with all ESTs]
    Unigene Representative Sequence: NM_000565
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368485(uc021paf.1 uc001fez.2 uc001ffa.2) ENST00000344086
    ENST00000512471 ENST00000476006 ENST00000515190 ENST00000507256 ENST00000502679

    miRNA
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    hsa-miR-3916 hsa-miR-629* hsa-miR-4324 hsa-miR-34c-5p hsa-miR-130a* hsa-miR-23c hsa-let-7i hsa-let-7e
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    Additional mRNA sequence: 

    AK223582.1 AK293013.1 AK312730.1 BC035327.1 BC089410.1 BC132684.1 BC132686.1 S72848.1 
    X12830.1 X58298.1 

    4 DOTS entries:

    DT.212938  DT.95267460  DT.121396157  DT.99934870 

    Selected AceView cDNA sequences (see all 138):

    S72848 AW468638 CB962465 AI434387 NM_181359 AA360912 AU185946 NM_000565 
    CD516644 AW468643 BX509093 N66556 AI971631 BQ223533 X58298 AA811863 
    AA054385 CD366694 BQ776866 H12031 CD609025 BG575786 BG032730 CD366551 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IL6R    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                                                                    -                                       
    SP2:                                                                    -                 -                     
    SP3:                                                                                                            
    SP4:                                                              -     -                                       
    SP5:                                -                                                                           


    ECgene alternative splicing isoforms for IL6R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL6R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCCCACG
    IL6R Expression
    About this image


    IL6R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Larynx (Respiratory System)
    IL6R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL6R Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.135087

    UniProtKB/Swiss-Prot: IL6RA_HUMAN, P08887
    Tissue specificity: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and
    serum

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL6R (see all 10): 
              Interferons & Receptors in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th17 Response in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL6R gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il6ra1 , 5 interleukin 6 receptor, alpha1, 5 68.37(n)1
    55.35(a)1
      3 (39.19 cM)5
    161941  NM_010559.21  NP_034689.21 
     898693245 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia il6r1 interleukin 6 receptor 45.02(n)
    35.57(a)
      100491081  XM_002943361.2  XP_002943407.2 
    zebrafish
    (Danio rerio)
    Actinopterygii il6r1 interleukin 6 receptor 43.38(n)
    32.6(a)
      100135755  NM_001114318.1  NP_001107790.1 


    ENSEMBL Gene Tree for IL6R (if available)
    TreeFam Gene Tree for IL6R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL6R gene
    IL11RA2  ENSG000002587282  EBI32  CNTFR2  

    Find genes that share paralogs with IL6R           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IL6R
    PGOHUM00000236254


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    IL6RA_HUMAN, P08887: Genetic variations in IL6R determine soluble IL6R serum levels [MIM:614689]
    IL6RA_HUMAN, P08887: Genetic variations in IL6R define the IL6 serum level quantitative trait locus [MIM:614752]


    Selected SNPs for IL6R (see all 1364)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22281451,2,,4
    C,F,Hother1160928971(+) GCAAGA/C/TTTCTT 3 D A mis1 int136EA MN NA NS WA CSA EU 9423
    rs57779111,2
    C,F--154376753(+) TTTTCT/-TTTTT 3 -- us2k1 trp33Minor allele frequency- -:0.33NA 6
    rs1118369511,2
    F--154384736(+) TTTTTC/TGTTTT 3 -- int11Minor allele frequency- T:0.50CSA 2
    rs344783411,2
    C--154390213(+) TTTTT-/T/TT  
            
    GAGAT
    3 -- int11NA 2
    rs758690351,2
    C,F--154397439(+) AGAGGG/TTTGTG 3 -- int11Minor allele frequency- T:0.50WA 2
    rs57779131,2
    C--154398997(+) GTCTCA/-AAAAA 3 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs341724801,2
    C--154399396(+) TTTTGT/-AGACG 3 -- int11Minor allele frequency- -:0.00NA 2
    rs349263461,2
    C--154406210(+) TTTTT-/TGAGAT 3 -- int10--------
    rs347228521,2
    C--154410357(+) TTTTT-/TAGTAG 3 -- int1 ut310--------
    rs2013353221,2
    C--154415264(+) TTCTTC/TTTTTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for IL6R (154377669 - 154441926 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL6R:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521887CNV Gain19592680

    Human Gene Mutation Database (HGMD): IL6R
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL6R
    DNA2.0 Custom Variant and Variant Library Synthesis for IL6R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147880   
    OMIM disorders: 614689  614752  
    14 diseases for IL6R:    
    About MalaCards
    nodular goiter    pleomorphic malignant fibrous histiocytoma    pycnodysostosis    castleman's disease
    preterm premature rupture of the membranes    myeloma    nodular regenerative hyperplasia    fibrous histiocytoma
    multiple myeloma    arteriovenous fistula    kaposi's sarcoma    histiocytoma
    prostate cancer    rheumatoid arthritis

    2 diseases from the University of Copenhagen DISEASES database for IL6R:
    Rheumatoid arthritis     Multiple myeloma

    Find genes that share disorders with IL6R           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL6R gene (see all 88)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloma 75.8 84 9674743 (6), 8939386 (3), 12515619 (3), 11028445 (3) (see all 42)
    castleman disease 62.6 2 8890706 (1), 12633573 (1)
    rheumatoid arthritis 56.3 26 18358926 (2), 11783141 (1), 18821691 (1), 9300938 (1) (see all 23)
    carcinoma giant cell 54.8 1 10374431 (1)
    leukemia 54.3 32 1429553 (2), 18472849 (2), 9630704 (1), 10374431 (1) (see all 24)
    necrosis 54 76 9857110 (3), 8720493 (2), 7500319 (2), 9077612 (2) (see all 54)
    response acute phase 51.6 3 8759474 (1), 19438606 (1), 18653811 (1)
    plasmacytoma 44.6 3 11090073 (2), 2073791 (1)
    kaposi sarcoma 42 3 7657807 (1), 9164976 (1), 9215976 (1)
    pycnodysostosis 41.6 1 7663521 (1)

    Genetic Association Database (GAD): IL6R
    Human Genome Epidemiology (HuGE) Navigator: IL6R (84 documents)

    Export disorders for IL6R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL6R gene, integrated from 10 sources (see all 763):
    (articles sorted by number of sources associating them with IL6R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants of IL-6 and its receptor are not associated with schizophrenia in Taiwan. (PubMed id 19914334)1, 4, 9 Liu Y.L....Hwu H.G. (Neurosci. Lett. 2010)
    2. Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma. (PubMed id 19503017)1, 4, 9 Corvol H.... . (Pharmacogenet. Genomics 2009)
    3. Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth. (PubMed id 18276608)1, 4, 9 Velez D.R....Menon R. (Hum. Mol. Genet. 2008)
    4. Multilocus interactions at maternal tumor necrosis factor-alpha, tumor necrosis factor receptors, interleukin-6 and interleukin-6 receptor genes predict spontaneous preterm labor in European-American women. (PubMed id 16731080)1, 4, 9 Menon R....Fortunato S.J. (Am. J. Obstet. Gynecol. 2006)
    5. Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced. (PubMed id 15306846)1, 4, 9 Galicia J.C....Yoshie H. (Genes Immun. 2004)
    6. Structure of the extracellular domains of the human interleukin-6 receptor alpha-chain. (PubMed id 12461182)1, 2, 9 Varghese J.N.... Simpson R.J. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women. (PubMed id 18852330)1, 4, 9 Qi L....Hu F.B. (Diabetes 2009)
    8. IL-6 receptor, IL-8 receptor and TNF-alpha238 (G/A) polymorphisms are not associated with BehAset's disease in patients of German or Turkish origin. (PubMed id 19026125)1, 4, 9 Storz K....KAPtter I. (Clin. Exp. Rheumatol. 2008)
    9. Interleukin-6 receptor gene variations, plasma interleukin-6 levels, and type 2 diabetes in U.S. Women. (PubMed id 17898129)1, 4, 9 Qi L....Hu F.B. (Diabetes 2007)
    10. Molecular screening and association analyses of the interleukin 6 receptor gene variants with type 2 diabetes, diabetic nephropathy, and insulin sensitivity. (PubMed id 15562008)1, 4, 9 Wang H....Elbein S.C. (J. Clin. Endocrinol. Metab. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3570 HGNC: 6019 AceView: IL6R Ensembl:ENSG00000160712 euGenes: HUgn3570
    ECgene: IL6R Kegg: 3570 H-InvDB: IL6R

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL6R Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL6R Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL6R gene:
    Search GeneIP for patents involving IL6R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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