IL6R Gene
protein-coding GIFtS: 67
GCID: GC01P154377
|
|
interleukin 6 receptor
| |
Aliases
for IL6R gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interleukin 6 Receptor1 2 | | IL-6R-12 | | CD1261 2 | | IL6Q2 | | Membrane Glycoprotein 802 3 | | IL6RA2 | | IL-6RA2 3 | | IL6RQ2 | | CD126 Antigen2 3 | | Interleukin-6 Receptor Subunit Alpha2 | | Gp801 | | IL-6R-Alpha1 | | IL-6 Receptor Subunit Alpha2 3 | | IL-6R Subunit Alpha3 | | IL-6R 12 3 | | |
Export aliases for IL6R gene to outside databasesPrevious GC identifers: GC01P152194 GC01P150108 GC01P151152 GC01P151594 GC01P151190 GC01P152644 GC01P125740 |
Summaries
for IL6R gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IL6R:
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokinethat regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor isa protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptorsubunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in thepathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternativelyspliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found onchromosome 9.(provided by RefSeq, May 2011)
UniProtKB/Swiss-Prot: IL6RA_HUMAN, P08887Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal.Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response,acute-phase reactions and hematopoiesisFunction: Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity
Gene Wiki entry for IL6R (Interleukin-6 receptor)
|
Genomic Views
for IL6R gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IL6R gene promoter:
GATA-3 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for IL6R
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL6R |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21IL6R Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P154377: view genomic region
(about GC identifiers)
Start:
|
154,377,669 bp from pter |
End:
|
154,441,926 bp from pter |
Size:
|
64,258 bases |
Orientation:
|
plus strand |
|
Proteins
for IL6R gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IL6RA_HUMAN, P08887 (See
protein sequence)Recommended Name: Interleukin-6 receptor subunit alpha precursor Size: 468 amino acids; 51548 Da
Subunit: Hexamer of two molecules each of IL6, IL6R and IL6ST
Subcellular location: Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
4 PDB 3D structures from  and Proteopedia  for IL6R:1N26 (3D)
1N2Q (3D)
1P9M (3D)
2ARW (3D)
Secondary accessions: A8KAE8 B2R6V4 Q16202 Q53EQ7 Q5FWG2 Q5VZ23Alternative splicing: 2 isoforms: P08887-1 P08887-2 Explore the universe of human proteins at neXtProt for IL6R: NX_P08887
Post-translational modifications:
A short soluble form may also be released from the membrane by proteolysis1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P08887
IL6R Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_000556.1 NP_001193795.1 NP_852004.1
ENSEMBL proteins: ENSP00000357470 ENSP00000340589 ENSP00000423184 ENSP00000423668 ENSP00000423036 Reactome Protein details: P08887
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
IL6R for ontologies About GeneDecksing
IL6R Antibody Products:
Assay Products for IL6R: |
Protein
Domains /
Families
for IL6R gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IL6R for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P08887ProtoNet protein and cluster: P08887 2 Blocks protein families: IPB003530 Long hematopoietin receptor IPB003598 Immunoglobulin C-2 type
UniProtKB/Swiss-Prot: IL6RA_HUMAN, P08887Domain: The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-bindingdomainDomain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellulartransport and cell-surface receptor bindingSimilarity: Belongs to the type I cytokine receptor family. Type 3 subfamilySimilarity: Contains 1 fibronectin type-III domainSimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain |
Function
for IL6R gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IL6RA_HUMAN, P08887Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal.Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response,acute-phase reactions and hematopoiesisFunction: Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity Genatlas biochemistry entry for IL6R:interleukin 6,receptor,alpha subunit,low activity receptor,heterodimerizing with IL6ST
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL6R (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL6R (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for IL6R | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6R |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6R |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
IL6R for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Il6ratm1.2Drew for IL6R
8 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Il6ra):
IL6R for phenotypes About GeneDecksing
|
Pathways & Interactions
for IL6R gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | PEDF Induced Signaling | | | 2 | Serine phosphorylation of STATs | | | 3 | TGF-Beta Pathway | | | 4 | Mucin expression in CF via IL-6, IL-17 signaling pathways | | | 5 | Akt Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for IL6R
2  R&D Systems Pathways for IL6R
5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL6R (see all 14)
5  GeneGo (Thomson Reuters) Pathways for IL6R
4  BioSystems Pathways for IL6R
5/7 
Reactome Pathways for IL6R (see all 7)
3 
Kegg Pathways (Kegg details for IL6R):
IL6R for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL6R
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/44 Interacting proteins for IL6R (P088872, 3 ENSP000003574704) via UniProtKB, MINT, STRING, and/or I2D (see all 44)About this table
Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35): About this table
IL6R for ontologies About GeneDecksing
|
Drugs & Compounds
for IL6R gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
IL6R for compounds About GeneDecksing
 Browse Tocris compounds for IL6R
1 DrugBank Compound for IL6R About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| Alpha-D-Mannose | -- | 3458-28-4 | target | -- | -- |
10/48 Novoseek chemical compound relationships for IL6R gene (see all 48) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gp 130 |
97 |
450 |
11238858 (6), 10813718 (6), 8720493 (5), 11884403 (5) (see all 99) |
| tocilizumab |
91.6 |
56 |
18653811 (5), 19365268 (2), 18358926 (2), 18664393 (2) (see all 32) |
| tapi |
64.4 |
4 |
7594530 (3) |
| af 10 |
42.8 |
6 |
7963520 (3), 2033252 (3) |
| dexamethasone |
37.7 |
29 |
9734662 (2), 7595216 (2), 8977259 (2), 15930364 (1) (see all 14) |
| retinoic acid |
29 |
27 |
2033252 (6), 10381520 (5), 7949175 (2), 9734662 (1) (see all 11) |
| rottlerin |
27.8 |
2 |
11485567 (1), 12832423 (1) |
| il 10 |
24.4 |
1 |
9083231 (1) |
| fibrinogen |
23.4 |
4 |
9722935 (1), 19739579 (1), 11282562 (1), 18496641 (1) |
| ifn-alpha |
23 |
3 |
11740974 (1), 12482347 (1) |
Search CenterWatch for drugs/clinical trials and news about IL6R / IL6RA
|
Transcripts
for IL6R gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IL6R gene (3 alternative transcripts): NM_000565.3 NM_001206866.1 NM_181359.2 Unigene Cluster for IL6R: Interleukin 6 receptor Hs.135087 [show with all ESTs]Unigene Representative Sequence: NM_0005657 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000368485(uc021paf.1 uc001fez.2 uc001ffa.2) ENST00000344086
ENST00000512471 ENST00000476006 ENST00000515190 ENST00000507256 ENST00000502679
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL6R (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL6R (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): IL6R (NM_000565) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL6R | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6R |
Additional cDNA sequence: AK223582.1 AK293013.1 AK312730.1 BC035327.1 BC089410.1 BC132684.1 BC132686.1 S72848.1 X12830.1 X58298.1 4 DOTS entries: DT.212938 DT.95267460 DT.121396157 DT.99934870 24/138 AceView cDNA sequences (see all 138): CB962465 NM_181359 AW468638 X58298 AA054385 S72848 AU185946 AI971631 BX509093 BQ223533 AI434387 AA811863 NM_000565 N66556 CD516644 AA360912 AW468643 BE221693 BM127832 CD366694 CK819171 AA411559 AA812014 CD515111
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for IL6R About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for IL6R
|
Expression
for IL6R gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IL6R expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGCCCACG
About this image
See IL6R Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL6R
SOURCE GeneReport for Unigene cluster: Hs.135087
UniProtKB/Swiss-Prot: IL6RA_HUMAN, P08887Tissue specificity: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum
SABiosciences Expression via Pathway-Focused PCR Arrays including IL6R (see all 10):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL6R
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL6R | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL6R | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL6R | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6R |
Orthologs
for IL6R gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IL6R gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
il6r1 |
interleukin 6 receptor |
43.69(n)
32.49(a) |
|
100135755 NM_001114318.1 NP_001107790.1 |
ENSEMBL Gene Tree for IL6R (if available)
TreeFam Gene Tree for IL6R (if available) |
Paralogs
for IL6R gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IL6R gene
- IL11RA2 ENSG000002587282 CRLF12 EBI32 CNTFR2
IL6R for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for IL6R
PGOHUM00000236254
|
Genomic Variants
for IL6R gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: IL6RA_HUMAN, P08887Polymorphism: Genetic variations in IL6R determine soluble IL6R serum levels [MIM:614689]Polymorphism: Genetic variations in IL6R define the IL6 serum level quantitative trait locus [MIM:614752]
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IL6R (154377669 - 154441926 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL6R: --
Human Gene Mutation Database (HGMD): IL6R
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL6R |
|
Disorders
/ Diseases
for IL6R gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IL6R for disorders About GeneDecksing
OMIM gene information: 147880
OMIM disorders: --
20/160  diseases for IL6R (see all 160): About MalaCardsinterleukin-7 receptor alpha deficiency multiple myeloma monoclonal gammopathy of undetermined significance malignant fibrous histiocytoma
prostate cancer myeloma fibrous histiocytoma adult-onset still's disease
pleomorphic malignant fibrous histiocytoma sudden infant death syndrome nodular regenerative hyperplasia prostatitis
nodular goiter non-small cell lung carcinoma ovarian hyperstimulation syndrome pre-eclampsia
interleukin receptor pycnodysostosis status epilepticus histiocytoma
1 disease from the University of Copenhagen DISEASES database for IL6R:Multiple myeloma 10/88 Novoseek disease relationships for IL6R gene (see all 88) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| myeloma |
75.8 |
84 |
9674743 (6), 8939386 (3), 12515619 (3), 11028445 (3) (see all 42) |
| castleman disease |
62.6 |
2 |
8890706 (1), 12633573 (1) |
| rheumatoid arthritis |
56.3 |
26 |
18358926 (2), 11783141 (1), 18821691 (1), 9300938 (1) (see all 23) |
| carcinoma giant cell |
54.8 |
1 |
10374431 (1) |
| leukemia |
54.3 |
32 |
1429553 (2), 18472849 (2), 9630704 (1), 10374431 (1) (see all 24) |
| necrosis |
54 |
76 |
9857110 (3), 8720493 (2), 7500319 (2), 9077612 (2) (see all 54) |
| response acute phase |
51.6 |
3 |
8759474 (1), 19438606 (1), 18653811 (1) |
| plasmacytoma |
44.6 |
3 |
11090073 (2), 2073791 (1) |
| kaposi sarcoma |
42 |
3 |
7657807 (1), 9164976 (1), 9215976 (1) |
| pycnodysostosis |
41.6 |
1 |
7663521 (1) |
Genetic Association Database (GAD): IL6R
Human Genome Epidemiology (HuGE) Navigator: IL6R (84 documents)
Export disorders for IL6R gene to outside databases
|
Publications
for IL6R gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IL6R gene, integrated from 9 sources (see all 741):
(articles sorted by number of sources associating them with IL6R) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced. (PubMed id 15306846)1, 4, 9 Galicia J.C....Yoshie H. (2004)
- Structure of the extracellular domains of the human interleukin-6 receptor alpha-chain. (PubMed id 12461182)1, 2, 9 Varghese J.N.... Simpson R.J. (2002)
- Molecular screening and association analyses of the interleukin 6 receptor gene variants with type 2 diabetes, diabetic nephropathy, and insulin sensitivity. (PubMed id 15562008)1, 4, 9 Wang H....Elbein S.C. (2005)
- The cytoplasmic domain of the interleukin-6 receptor gp80 mediates its basolateral sorting in polarized madin-darby canine kidney cells. (PubMed id 11017875)1, 2, 9 Martens A.S.... Graeve L. (2000)
- Hexameric structure and assembly of the interleukin-6/IL-6 alpha- receptor/gp130 complex. (PubMed id 12829785)1, 2, 9 Boulanger M.J.... Garcia K.C. (2003)
- Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130. (PubMed id 8467812)1, 2, 9 Yawata H.... Kishimoto T. (1993)
- Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites. (PubMed id 15561970)1, 4, 9 Hamid Y.H....Pedersen O. (2004)
- Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels. (PubMed id 17357077)1, 2 Reich D....Ziv E. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Increased association with detergent-resistant membranes/lipid rafts of apically targeted mutants of the interleukin-6 receptor gp80. (PubMed id 16270750)1, 2 Buk D.M.... Graeve L. (2005)
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External Searches for IL6R gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing IL6R gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing IL6R gene
(According to HUGE)
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Specialized Databases showing IL6R gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for IL6R gene:
Search GeneIP for patents involving IL6R
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for IL6R gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IL6R | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL6R | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL6R | | | OriGene Protein Over-expression Lysate for IL6R | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IL6R | | OriGene 3'-UTR Clone for IL6R | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL6R | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL6R | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IL6R | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IL6R | | OriGene Custom Protein Services for IL6R | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL6R | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL6R | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL6R | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL6R | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL6R | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL6R |
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| | | | Search Tocris compounds for IL6R |
| |  |  |  |  | | | | | | Recombinant Protein for IL6R |
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 | | | IL6R Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6R |
|  |  |  | | | | ThermoFisher Antibody for IL6R |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6R |
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