Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL6R Gene

protein-coding   GIFtS: 70
GCID: GC01P154377

Interleukin 6 Receptor

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 6 Receptor1 2     IL-6R-12
Membrane Glycoprotein 802 3     IL6Q2
IL-6RA2 3     IL6RA2
CD126 Antigen2 3     IL6RQ2
gp802 3     Interleukin-6 Receptor Subunit Alpha2
IL-6 Receptor Subunit Alpha2 3     IL-6R-alpha3
IL-6R 12 3     IL-6R Subunit Alpha3
CD1262     

External Ids:    HGNC: 60191   Entrez Gene: 35702   Ensembl: ENSG000001607127   OMIM: 1478805   UniProtKB: P088873   

Export aliases for IL6R gene to outside databases

Previous GC identifers: GC01P152194 GC01P150108 GC01P151152 GC01P151594 GC01P151190 GC01P152644 GC01P125740


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL6R Gene:
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic
cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The
IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer
(IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6
and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune
diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been
reported. A pseudogene of this gene is found on chromosome 9.(provided by RefSeq, May 2011)

GeneCards Summary for IL6R Gene: 
IL6R (interleukin 6 receptor) is a protein-coding gene. Diseases associated with IL6R include nodular goiter, and pleomorphic malignant fibrous histiocytoma, and among its related super-pathways are STAT3 Pathway and MAPK Family Pathway. GO annotations related to this gene include interleukin-6 receptor binding and protein homodimerization activity. An important paralog of this gene is IL11RA.

UniProtKB/Swiss-Prot: IL6RA_HUMAN, P08887
Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal.
Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune
response, acute-phase reactions and hematopoiesis
Function: Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity

Gene Wiki entry for IL6R (Interleukin-6 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL6R gene promoter:
         GATA-3   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL6R promoter sequence
   Search SABiosciences Chromatin IP Primers for IL6R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL6R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

IL6R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL6R gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P154377:  view genomic region     (about GC identifiers)

Start:
154,377,669 bp from pter      End:
154,441,926 bp from pter
Size:
64,258 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL6RA_HUMAN, P08887 (See protein sequence)
Recommended Name: Interleukin-6 receptor subunit alpha precursor  
Size: 468 amino acids; 51548 Da
Subunit: Hexamer of two molecules each of IL6, IL6R and IL6ST
Subcellular location: Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
4 PDB 3D structures from and Proteopedia for IL6R:
1N26 (3D)        1N2Q (3D)        1P9M (3D)        2ARW (3D)    
Secondary accessions: A8KAE8 B2R6V4 Q16202 Q53EQ7 Q5FWG2 Q5VZ23
Alternative splicing: 2 isoforms:  P08887-1   P08887-2   

Explore the universe of human proteins at neXtProt for IL6R: NX_P08887

Explore proteomics data for IL6R at MOPED 

Post-translational modifications:

  • UniProtKB: A short soluble form may also be released from the membrane by proteolysis
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08887

  • IL6R Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL6R Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_000556.1  NP_001193795.1  NP_852004.1  

    ENSEMBL proteins: 
     ENSP00000357470   ENSP00000340589   ENSP00000423184   ENSP00000423668   ENSP00000423036  
    Reactome Protein details: P08887
    Human Recombinant Protein Products for IL6R: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL6R (IL-6 R alpha)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IL6R
    OriGene Protein Over-expression Lysate for IL6R
    OriGene MassSpec for IL6R 
    OriGene Custom Protein Services for IL6R
    GenScript Custom Purified and Recombinant Proteins Services for IL6R
    Novus Biologicals IL6R Proteins
    Novus Biologicals IL6R Lysates
    Sino Biological Recombinant Protein for IL6R
    Sino Biological Cell Lysate for IL6R 
    ProSpec Recombinant Protein for IL6R
    Cloud-Clone Corp. Proteins for IL6R 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA12419823
    GO:0005886plasma membrane TAS--
    GO:0005896interleukin-6 receptor complex IDA12829785
    GO:0009986cell surface IEA--

    IL6R for ontologies           About GeneDecksing



    IL6R Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL6R
    R&D Systems Antibodies for IL6R (IL-6 R alpha)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IL6R
    GenScript Custom Superior Antibodies Services for IL6R
    Novus Biologicals IL6R Antibodies
    Abcam antibodies for IL6R
    Cloud-Clone Corp. Antibodies for IL6R 
    ThermoFisher Antibodies for IL6R
    LSBio Antibodies in human, mouse, rat for IL6R 

    Assay Products for IL6R: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL6R
    R&D Systems ELISAs for IL6R (IL-6 R alpha)         (see all)
    GenScript Custom Assay Services for IL6R
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL6R 
    Cloud-Clone Corp. CLIAs for IL6R


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin-6 receptor, α subunit 
    IL-6 receptor family

    5/6 InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR015321 IL6_recept-bd
     IPR003961 Fibronectin_type3
     IPR003530 Hematopoietin_rcpt_L_F3_CS
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P08887

    ProtoNet protein and cluster: P08887

    2 Blocks protein domains:
    IPB003530 Long hematopoietin receptor
    IPB003598 Immunoglobulin C-2 type


    UniProtKB/Swiss-Prot: IL6RA_HUMAN, P08887
    Domain: The two fibronectin type-III-like domains, contained in the N-terminal part, form together a
    cytokine-binding domain
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Similarity: Belongs to the type I cytokine receptor family. Type 3 subfamily
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    IL6R for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL6RA_HUMAN, P08887
    Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal.
    Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune
    response, acute-phase reactions and hematopoiesis
    Function: Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity

         Genatlas biochemistry entry for IL6R:
    interleukin 6,receptor,alpha subunit,low activity receptor,heterodimerizing with IL6ST

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004897contributes to ciliary neurotrophic factor receptor activity IMP12643274
    GO:0004915contributes to interleukin-6 receptor activity IDA2261637
    GO:0005138contributes to interleukin-6 receptor binding IPI12829785
    GO:0005515protein binding IPI16034137
    GO:0019899enzyme binding IPI12748171
         
    IL6R for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Il6ra):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     immune system  liver/biliary system  normal 

    IL6R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il6ratm1.2Drew for IL6R

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL6R 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL6R

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL6R 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL6R 

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL6R:
    hsa-mir-23a (MIRT005528)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL6R
    8/66 QIAGEN miScript miRNA Assays for microRNAs that regulate IL6R (see all 66):
    hsa-miR-3916 hsa-miR-629* hsa-miR-4324 hsa-miR-34c-5p hsa-miR-130a* hsa-miR-23c hsa-let-7i hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidIL6R 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL6R
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL6R

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL6R
    Sirion Biotech Customized adenovirus for overexpression of IL6R

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IL6R (see all 13)
    OriGene ORF clones in mouse, rat for IL6R
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IL6R (NM_000565)
    Sino Biological Human cDNA Clone for IL6R
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6R
    Sirion Biotech Customized lentivirus for stable overexpression of IL6R 
                         Customized lentivirus expression plasmids for stable overexpression of IL6R 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL6R
    Search LifeMap BioReagents cell lines for IL6R
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6R


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL6R About   (see all 24)                                                                                              See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    IL-6 Pathway0.61
    Glucocorticoid Receptor Signaling0.43
    PGC1Alpha Pathway0.51
    Cytokine-cytokine receptor interaction0.43
    STAT3 Pathway0.47
    2TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF0.72
    Cytokine production by Th17 cells in CF (Mouse model)0.72
    5Th17 Differentiation
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47
    Th17 Differentiation0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for IL6R
        Transcription Androgen Receptor nuclear signaling
    Immune response IL-6 signaling pathway

    2 R&D Systems Pathways for IL6R
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th17 Differentiation

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL6R (see all 14)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Glucocorticoid Receptor Signaling
    JAK-STAT Pathway

    5 GeneGo (Thomson Reuters) Pathways for IL6R
        Immune response IL-6 signaling pathway
    Transcription Androgen Receptor nuclear signaling
    Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF
    Mucin expression in CF via IL-6, IL-17 signaling pathways

    4 BioSystems Pathways for IL6R
        Senescence and Autophagy
    SIDS Susceptibility Pathways
    IL-6 Signaling Pathway
    IL6-mediated signaling events


    4        Reactome Pathways for IL6R
        Interleukin-6 signaling
    Cytokine Signaling in Immune system
    Signaling by Interleukins
    Immune System


    5/6         Kegg Pathways  (Kegg details for IL6R) (see all 6):
        Cytokine-cytokine receptor interaction
    HIF-1 signaling pathway
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway
    Hematopoietic cell lineage


    IL6R for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL6R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for IL6R (P088872, 3 ENSP000003574704) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JAK1P234582, 3, ENSP000003432044MINT-15143 I2D: score=1 STRING: ENSP00000343204
    WWP2O003083, ENSP000003482834I2D: score=1 STRING: ENSP00000348283
    IL6P052313, ENSP000002587434I2D: score=5 STRING: ENSP00000258743
    IL6STP401893, ENSP000003387994I2D: score=5 STRING: ENSP00000338799
    CNTFP264413, ENSP000003553704I2D: score=2 STRING: ENSP00000355370
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002384hepatic immune response TAS12832423
    GO:0002446neutrophil mediated immunity IC16034137
    GO:0002548monocyte chemotaxis IC10510402
    GO:0002690positive regulation of leukocyte chemotaxis TAS15100312
    GO:0006953acute-phase response TAS12832423

    IL6R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL6R for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL6R (IL6RA)

    2 DrugBank Compounds for IL6R    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TocilizumabAtlizumab (see all 4)375823-41-9targetantibody16899109
    Alpha-D-Mannose-- 3458-28-4target----

    10/48 Novoseek inferred chemical compound relationships for IL6R gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 97 450 11238858 (6), 10813718 (6), 8720493 (5), 11884403 (5) (see all 99)
    tocilizumab 91.6 56 18653811 (5), 19365268 (2), 18358926 (2), 18664393 (2) (see all 32)
    tapi 64.4 4 7594530 (3)
    af 10 42.8 6 7963520 (3), 2033252 (3)
    dexamethasone 37.7 29 9734662 (2), 7595216 (2), 8977259 (2), 15930364 (1) (see all 14)
    retinoic acid 29 27 2033252 (6), 10381520 (5), 7949175 (2), 9734662 (1) (see all 11)
    rottlerin 27.8 2 11485567 (1), 12832423 (1)
    il 10 24.4 1 9083231 (1)
    fibrinogen 23.4 4 9722935 (1), 19739579 (1), 11282562 (1), 18496641 (1)
    ifn-alpha 23 3 11740974 (1), 12482347 (1)

    Search CenterWatch for drugs/clinical trials and news about IL6R / IL6RA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL6R gene (3 alternative transcripts): 
    NM_000565.3  NM_001206866.1  NM_181359.2  

    Unigene Cluster for IL6R:

    Interleukin 6 receptor
    Hs.135087  [show with all ESTs]
    Unigene Representative Sequence: NM_000565
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368485(uc021paf.1 uc001fez.2 uc001ffa.2) ENST00000344086
    ENST00000512471 ENST00000476006 ENST00000515190 ENST00000507256 ENST00000502679

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL6R
    8/66 QIAGEN miScript miRNA Assays for microRNAs that regulate IL6R (see all 66):
    hsa-miR-3916 hsa-miR-629* hsa-miR-4324 hsa-miR-34c-5p hsa-miR-130a* hsa-miR-23c hsa-let-7i hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidIL6R 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL6R
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL6R
    Clone
    Products:
         
    OriGene clones in human, mouse for IL6R (see all 13)
    OriGene ORF clones in mouse, rat for IL6R
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IL6R (NM_000565)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6R
    Sirion Biotech Customized lentivirus for stable overexpression of IL6R 
                         Customized lentivirus expression plasmids for stable overexpression of IL6R 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL6R
    OriGene qSTAR qPCR primer pairs in human, mouse for IL6R
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL6R
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL6R
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL6R

    Additional mRNA sequence: 

    AK223582.1 AK293013.1 AK312730.1 BC035327.1 BC089410.1 BC132684.1 BC132686.1 S72848.1 
    X12830.1 X58298.1 

    4 DOTS entries:

    DT.212938  DT.95267460  DT.121396157  DT.99934870 

    24/138 AceView cDNA sequences (see all 138):

    AA811863 CD516644 BX509093 BQ223533 AU185946 CB962465 AI971631 AA360912 
    X58298 N66556 NM_000565 S72848 AA054385 AW468638 AW468643 AI434387 
    NM_181359 BG498550 BM015654 BF439066 BE221693 AA381253 BM128112 BQ937176 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IL6R    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                                                                    -                                       
    SP2:                                                                    -                 -                     
    SP3:                                                                                                            
    SP4:                                                              -     -                                       
    SP5:                                -                                                                           


    ECgene alternative splicing isoforms for IL6R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL6R expression in normal human tissues (normalized intensities)      IL6R embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCCCACG
    IL6R Expression
    About this image


    IL6R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             neutrophils   
     
     Bone (Muscoskeletal System)
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Larynx (Respiratory System)

    See IL6R Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL6R

    SOURCE GeneReport for Unigene cluster: Hs.135087

    UniProtKB/Swiss-Prot: IL6RA_HUMAN, P08887
    Tissue specificity: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and
    serum

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL6R (see all 10): 
              Interferons & Receptors in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th17 Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL6R
    OriGene qSTAR qPCR primer pairs in human, mouse for IL6R
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL6R
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL6R
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL6R
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6R

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL6R gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il6ra1 , 5 interleukin 6 receptor, alpha1, 5 68.94(n)1
    55.73(a)1
      3 (39.19 cM)5
    161941  NM_010559.21  NP_034689.21 
     898693245 
    zebrafish
    (Danio rerio)
    Actinopterygii il6r1 interleukin 6 receptor 43.69(n)
    32.49(a)
      100135755  NM_001114318.1  NP_001107790.1 


    ENSEMBL Gene Tree for IL6R (if available)
    TreeFam Gene Tree for IL6R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL6R gene
    IL11RA2  ENSG000002587282  EBI32  CNTFR2  

    IL6R for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IL6R
    PGOHUM00000236254


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: IL6RA_HUMAN, P08887
    Polymorphism: Genetic variations in IL6R determine soluble IL6R serum levels [MIM:614689]
    Polymorphism: Genetic variations in IL6R define the IL6 serum level quantitative trait locus [MIM:614752]


    10/1364 SNPs in IL6R are shown (see all 1364)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22281451,2,4
    C,F,Hother1160928971(+) GCAAGA/C/TTTCTT 3 D A mis1 int136EA MN NA NS WA CSA EU 9423
    VAR_0491664
    ----see VAR_0491662 V I mis40--------
    rs57779111,2
    C,F--154376753(+) TTTTCT/-TTTTT 3 -- us2k1 trp33Minor allele frequency- -:0.33NA 6
    rs1118369511,2
    F--154384736(+) TTTTTC/TGTTTT 3 -- int11Minor allele frequency- T:0.50CSA 2
    rs344783411,2
    C--154390213(+) TTTTT-/T/TT  
            
    GAGAT
    3 -- int11NA 2
    rs758690351,2
    C,F--154397439(+) AGAGGG/TTTGTG 3 -- int11Minor allele frequency- T:0.50WA 2
    rs57779131,2
    C--154398997(+) GTCTCA/-AAAAA 3 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs341724801,2
    C--154399396(+) TTTTGT/-AGACG 3 -- int11Minor allele frequency- -:0.00NA 2
    rs349263461,2
    C--154406210(+) TTTTT-/TGAGAT 3 -- int10--------
    rs347228521,2
    C--154410357(+) TTTTT-/TAGTAG 3 -- int1 ut310--------

    HapMap Linkage Disequilibrium report for IL6R (154377669 - 154441926 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL6R:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv521887CNV Gain19592680


    Human Gene Mutation Database (HGMD): IL6R
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL6R
    DNA2.0 Custom Variant and Variant Library Synthesis for IL6R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147880    OMIM disorders: --

    20/139 diseases for IL6R (see all 139):    About MalaCards
    nodular goiter    pleomorphic malignant fibrous histiocytoma    castleman's disease    multicentric castleman disease
    follicular adenoma    pycnodysostosis    myeloma    multiple myeloma
    joint disorders    interleukin-7 receptor alpha deficiency    preterm premature rupture of the membranes    fibrous histiocytoma
    kaposi's sarcoma    nodular regenerative hyperplasia    ovarian hyperstimulation syndrome    histiocytoma
    goiter    takayasu's arteritis    megakaryocytic leukemia    plasmacytoma

    2 diseases from the University of Copenhagen DISEASES database for IL6R:
    Rheumatoid arthritis     Multiple myeloma

    IL6R for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/88 Novoseek inferred disease relationships for IL6R gene (see all 88)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloma 75.8 84 9674743 (6), 8939386 (3), 12515619 (3), 11028445 (3) (see all 42)
    castleman disease 62.6 2 8890706 (1), 12633573 (1)
    rheumatoid arthritis 56.3 26 18358926 (2), 11783141 (1), 18821691 (1), 9300938 (1) (see all 23)
    carcinoma giant cell 54.8 1 10374431 (1)
    leukemia 54.3 32 1429553 (2), 18472849 (2), 9630704 (1), 10374431 (1) (see all 24)
    necrosis 54 76 9857110 (3), 8720493 (2), 7500319 (2), 9077612 (2) (see all 54)
    response acute phase 51.6 3 8759474 (1), 19438606 (1), 18653811 (1)
    plasmacytoma 44.6 3 11090073 (2), 2073791 (1)
    kaposi sarcoma 42 3 7657807 (1), 9164976 (1), 9215976 (1)
    pycnodysostosis 41.6 1 7663521 (1)

    Genetic Association Database (GAD): IL6R
    Human Genome Epidemiology (HuGE) Navigator: IL6R (84 documents)

    Export disorders for IL6R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL6R gene, integrated from 9 sources (see all 755):
    (articles sorted by number of sources associating them with IL6R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants of IL-6 and its receptor are not ass ociated with schizophrenia in Taiwan. (PubMed id 19914334)1, 4, 9 Liu Y.L....Hwu H.G. (2009)
    2. Genetic ancestry modifies pharmacogenetic gene-gene i nteraction for asthma. (PubMed id 19503017)1, 4, 9 Corvol H....Burchard E.G. (2009)
    3. Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth. (PubMed id 18276608)1, 4, 9 Velez D.R....Menon R. (2008)
    4. Multilocus interactions at maternal tumor necrosis factor-alpha, tumor necrosis factor receptors, interleukin-6 and interleukin-6 receptor genes predict spontaneous preterm labor in European-American women. (PubMed id 16731080)1, 4, 9 Menon R....Fortunato S.J. (2006)
    5. Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced. (PubMed id 15306846)1, 4, 9 Galicia J.C....Yoshie H. (2004)
    6. Structure of the extracellular domains of the human interleukin-6 receptor alpha-chain. (PubMed id 12461182)1, 2, 9 Varghese J.N.... Simpson R.J. (2002)
    7. Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women. (PubMed id 18852330)1, 4, 9 Qi L....Hu F.B. (2009)
    8. IL-6 receptor, IL-8 receptor and TNF-alpha238 (G/A) polymorphisms are not associated with Behcet's disease in patients of German or Turkish origin. (PubMed id 19026125)1, 4, 9 Storz K....Kotter I. (2008)
    9. Interleukin-6 receptor gene variations, plasma interleukin-6 levels, and type 2 diabetes in U.S. Women. (PubMed id 17898129)1, 4, 9 Qi L....Hu F.B. (2007)
    10. Molecular screening and association analyses of the interleukin 6 receptor gene variants with type 2 diabetes, diabetic nephropathy, and insulin sensitivity. (PubMed id 15562008)1, 4, 9 Wang H....Elbein S.C. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3570 HGNC: 6019 AceView: IL6R Ensembl:ENSG00000160712 euGenes: HUgn3570
    ECgene: IL6R Kegg: 3570 H-InvDB: IL6R

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL6R Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL6R Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL6R gene:
    Search GeneIP for patents involving IL6R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of IL6R
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for IL6R (IL-6 R alpha)   Browse Cell Culture Products  
     ELISAs for IL6R (IL-6 R alpha)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for IL6R (IL-6 R alpha)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for IL6R (IL-6 R alpha)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for IL6R (IL-6 R alpha)  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IL6R  
     OriGene qPCR primer pairs and template standards for IL6R   OriGene Protein Over-expression Lysate for IL6R  
     OriGene MassSpec something-or-other for IL6R   OriGene clones in human, mouse for IL6R  
     OriGene qSTAR qPCR primer pairs in human, mouse for IL6R   OriGene Purified Protein for IL6R  
     OriGene ORF clones in mouse, rat for IL6R   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IL6R   OriGene Custom Protein Services for IL6R  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL6R
     QIAGEN SeqTarget long-range PCR primers for resequencing IL6R
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL6R
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL6R
     Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL6R
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL6R
     GenScript Custom Purified and Recombinant Proteins Services for IL6R GenScript cDNA clones with any tag delivered in your preferred vector for IL6R
     GenScript Custom Assay Services for IL6R GenScript Custom Superior Antibodies Services for IL6R
     GenScript Custom overexpressing Cell Line Services for IL6R CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IL6R promoter
     Search Chromatin IP Primers for IL6R
     RT2 qPCR Primer Assay in human, mouse, rat IL6R
     GNC Network for IL6R
     SABiosciences PCR Arrays including human, mouse, rat IL6R
     Search Tocris compounds for IL6R (IL6RA)
     Proteins and Antibodies for IL6R
     Cell Lysates for IL6R
     cDNA Clones for IL6R
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IL6R antibodies
     IL6R proteins
     IL6R lysates
     Antibodies for IL6R
     See all of Abcam's Antibodies, Kits and Proteins for IL6R
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for IL6R




     Proteins for IL6R
     Antibodies for IL6R
     ELISAs for IL6R
     CLIAs for IL6R
     Search LifeMap BioReagents cell lines for IL6R
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6R
     SwitchGear 3'UTR luciferase reporter plasmids for IL6R
     SwitchGear Promoter luciferase reporter plasmids for IL6R
     ThermoFisher Antibodies for IL6R
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6R
     inGenious Targeting Laboratory - Custom generated mouse model solutions for IL6R
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL6R
    Customized:
     lentivirus for stable overexpression of IL6R
     lentivirus expression plasmids for stable overexpression of IL6R
     adenovirus for overexpression of IL6R
     LSBio Antibodies in human, mouse, rat for IL6R
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IL6R gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4