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IL6 Gene

protein-coding GIFtS: 71

GC07P022732

interleukin 6 (interferon, beta 2)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: IFNB2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
BSF-2 ^³
BSF2 ^¹, ², ⁵
CDF ^³
HGF ^¹, ², ⁵
HSF ^¹, ², ⁵
IFNB2 ^², ³, ⁵
IL-6 ^¹, ², ³

Descriptions
B cell stimulatory factor-2 ^²
B-cell differentiation factor ^²
B-cell stimulatory factor 2 ^³
CTL differentiation factor ^², ³
Hybridoma growth factor ^², ³
Interferon beta-2 ^³
interleukin 6 ^²
interleukin 6 (interferon, beta 2) ^²
interleukin BSF-2 ^²

External Ids
HGNC: 6018¹
Entrez Gene: 3569²
UniProtKB: P05231³
Ensembl: ENSG00000136244⁷

Search outside databases for aliases for IL6 gene

Previous GC identifers: GC07P022409 GC07P022509 GC07P022540

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IL6:

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. The

protein is primarily produced at sites of acute and chronic inflammation, where it is secreted

into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor,

alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated

disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid

arthritis. [provided by RefSeq]

UniProtKB/Swiss-Prot: IL6_HUMAN, P05231

Function: IL-6 is a cytokine with a wide variety of biological functions: it plays an essential

role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and

plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase

reactants

Gene Wiki entry for IL6 (Interleukin_6)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IL6 gene

Entrez Gene cytogenetic band: 7p21 Ensembl cytogenetic band: 7p15.3 HGNC cytogenetic band: 7p21-p15

IL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P022732: (about GC identifiers)

Start:	22,732,028 bp from pter
End:	22,738,146 bp from pter
Size:	6,119 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 22,817,927-22,822,729

RefSeq DNA sequence:

NC_000007.12 NT_007819.16 NT_079592.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IL6_HUMAN, P05231 (See protein sequence)

Recommended Name: Interleukin-6 precursor

Size: 212 amino acids; 23718 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

1ALU (3D)

1IL6 (3D)

1N2Q (3D)

1P9M (3D)

2IL6 (3D)

Secondary accessions: Q9UCU2 Q9UCU3 Q9UCU4

Post-translational modifications:

N- and O-glycosylated¹

REFSEQ proteins: NP_000591.1

ENSEMBL proteins:

ENSP00000258743 ENSP00000385675 ENSP00000385718 ENSP00000385043 ENSP00000385227 ENSP00000384928

Human Recombinant Proteins

	Invitrogen human recombinant proteins for IL6
	Millipore Purified and/or Recombinant IL6 Protein
	Sigma-Aldrich Proteins and AQUA Peptides for IL6
	R&D Systems Recombinant & Natural Proteins for IL6 (IL-6)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IL6)
	Human Recombinant Proteins from Abnova (IL6)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--
GO:0005896	interleukin-6 receptor complex	IDA	2261637 12829785

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Antibodies for IL6:

	Invitrogen Antibodies for IL6
	Millipore Mono- and Polyclonal Antibodies for the study of IL6
	Sigma-Aldrich Antibodies for IL6
	R&D Systems Antibodies for IL6 (IL-6)
	Antibodies from Abcam (IL6), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for IL6

Assays for IL6:

	Invitrogen Assays for IL6
	Millipore Kits and Assays for the Analysis of IL6
	R&D Systems Flow Cytometry Kits for IL6 (IL-6) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P05231

ProtoNet protein and cluster: P05231

1 Blocks protein family: IPB003574 Interleukin-6 signature

UniProtKB/Swiss-Prot: IL6_HUMAN, P05231

Similarity: Belongs to the IL-6 superfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IL6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IL6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC015511

Applied Biosystems Silencer® siRNAs for IL6

Sigma-Aldrich siRNA and siRNA Panels for IL6

Sigma-Aldrich shRNA Panels and shRNA for IL6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IL6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000600
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000600
untagged cDNA clones in CMV expression vector (see all 2): BC015511

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000600

UniProtKB/Swiss-Prot: IL6_HUMAN, P05231

Function: IL-6 is a cytokine with a wide variety of biological functions: it plays an essential

role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and

plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase

reactants

Genatlas biochemistry entry for IL6:

interleukin 6,23.7kDa,involved in the regulation of immune response,hematopoiesis,platelet

production,acute phase reaction and bone resorption (susceptibility factor for osteopenia),playing

a role in the aggressiveness of non hodgkin lymphoma by stimulating MMP2 and MMP9

12 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Il6):

behavior/neurological	digestive/alimentary	growth/size	hematopoietic system	homeostasis/metabolism
immune system	life span-post-weaning/aging	liver/biliary system	nervous system	skeleton
touch/vibrissae	tumorigenesis

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005138	interleukin-6 receptor binding	NAS	1883960

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/21 Sigma-Aldrich "Your Favorite Gene" Pathways for IL6 (Your Favorite Gene powered by Ingenuity) (see all 21 )

Dendritic Cell Maturation
Aryl Hydrocarbon Receptor Signaling
Graft-versus-Host Disease Signaling
Glucocorticoid Receptor Signaling
IL-10 Signaling

GeneDecks IL6 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for IL6

5/436 Interacting proteins for IL6 (P05231² ENSP00000258743³) via UniProtKB, MINT, and/or STRING (see all 436 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SH3GL2	Q99962²	MINT-63404
IL17A	ENSP00000344192³	STRING (score=.999)
IL6R	ENSP00000357470³	STRING (score=.999)
IL6ST	ENSP00000338799³	STRING (score=.999)
OSM	ENSP00000215781³	STRING (score=.999)

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5/41 Gene Ontology (GO) biological process terms (links to tree view) (see all 41 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001781	neutrophil apoptosis	IDA	7595060
GO:0002384	hepatic immune response	TAS	12832423
GO:0002446	neutrophil mediated immunity	IC	16034137
GO:0002548	monocyte chemotaxis	IC	10510402
GO:0002675	positive regulation of acute inflammatory response	IDA	2444978

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for IL6:

Antagonist

Browse Tocris compounds for IL6
10/33 Novoseek chemical compound relationships for IL6 gene (see all 33 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gp 130	92.15	1216	7812050 (6), 9126968 (5), 1602143 (5), 8467812 (5) (see all 99)
endotoxin	81.62	813	8243265 (7), 11990931 (6), 10499730 (6), 8542650 (4) (see all 99)
rantes	80.50	536	16413378 (6), 16466762 (6), 12509950 (6), 8831850 (5) (see all 99)
il 10	77.14	219	19084425 (6), 12394188 (5), 12719394 (5), 15297015 (4) (see all 99)
tocilizumab	76.31	86	18784373 (7), 16102523 (4), 17214583 (3), 18664393 (3) (see all 43)
neopterin	74.01	304	1933885 (6), 9243197 (6), 10211419 (5), 8844226 (4) (see all 99)
fibrinogen	72.23	970	16703188 (8), 10959691 (6), 16159604 (5), 15155967 (5) (see all 99)
lipoteichoic acid	56.63	54	10858210 (4), 15379983 (3), 12906718 (2), 14638469 (2) (see all 26)
nitric oxide	55.51	981	9160463 (8), 14504722 (7), 11069732 (6), 15531955 (6) (see all 99)
il-12	55.48	36	11479428 (5), 15140777 (2), 16943231 (2), 17266151 (2) (see all 27)

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2 PharmGKB drug compound relationships for IL6 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
dexamethasone	FA	2233715
glucocorticoids	FA	2233715 1370208 8429822

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IL6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IL6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC015511

Sigma-Aldrich siRNA and siRNA Panels for IL6

Sigma-Aldrich shRNA Panels and shRNA for IL6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000600

REFSEQ mRNAs for IL6 gene:

NM_000600.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000600

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000600
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000600
                                 untagged cDNA clones in CMV expression vector (see all 2): BC015511

Additional cDNA sequence:

AK298013.1 AK298077.1 AK301141.1 BC015511.1 BT019748.1 BT019749.1 CR450296.1 CR590965.1

CR624632.1 CR626263.1 M14584.1 M18403.1 M29150.1 M54894.1 S56892.1 X04403.1

X04430.1 X04602.1

7 DOTS entries:

DT.212868 DT.91771152 DT.85101821 DT.40189406 DT.121119373 DT.40128177 DT.95261924

24/141 AceView cDNA sequences (see all 141 ):

CD367420 AI472218 CA308665 CD368463 AU102636 CA308172 AI632696 BM675188

BQ001320 CA306654 AA381892 NM_000600 CD743002 BQ008421 BM996808 C21585

CA306986 CD013918 AW966001 BM054692 M18403 BM994425 AI085963 AL544265

highest scoring ESTs for IL6:

X04430 AA911581 AA947476 AI074123 AI085963 AI095255 AI343270 AI632696 AI735329 AI751500

Unigene Cluster for IL6:

Interleukin 6 (interferon, beta 2)

Hs.654458 [show with all ESTs]

Unigene Representative Sequence: BM906445

GeneLoc Exon Structure

6 Ensembl transcripts including schematic representations:

ENST00000258743 ENST00000404625 ENST00000401651 ENST00000407492 ENST00000406575 ENST00000401630

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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IL6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IL6

¹ / ² / ³

3 probe-sets matching IL6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38299_at²^{, 3}	U95-A	2	1.00	0.97	1.00	1.00	X04430	1.00	1.00	1.00	1
205207_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000600	0.60	1.00	0.82	1
205207_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IL6 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCACCTCAG

SOURCE GeneReport for Unigene cluster: Hs.654458
Expression variation in blood from EXPOLDB for IL6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for IL6 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IL6¹	--	interleukin 6 (interferon, beta 2)	76.97(n) 60.87(a)	403985 XM_850499.1 XP_855592.1
chimpanzee (Pan troglodytes)	IL6¹	--	interleukin 6 (interferon, beta 2)	99.69(n) 99.53(a)	463288 XM_001154511.1 XP_001154511.1
cow (Bos taurus)	IL6¹	--	interleukin 6 (interferon, beta 2)	72.98(n) 54.85(a)	280826 NM_173923.2 NP_776348.1
rat (Rattus norvegicus)	Il6¹	--	interleukin 6	60.9(n) 41.83(a)	24498 NM_012589.1 NP_036721.1
mouse (Mus musculus)	Il6^{1, 5}	5 (17.00 cM)⁵	interleukin 6^{1, 5}	61.24(n)¹ 41.63(a)¹	16193¹ NM_031168.1¹ NP_112445.1¹ AK089780⁵ AK150440⁵ (see all 17)

About this table Species with no ortholog for IL6

ENSEMBL Gene Tree for IL6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: IL6_HUMAN, P05231

Polymorphism: Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD

is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral

density, disrutption of bone microarchitecture, and the alteration of the amount and variety of

non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture

10/111 NCBI SNPs in IL6 are shown (see all 111 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 79)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs1800795^1,2	A,C,F,H,O	22733170(+)	`CTTGCG/CATGCT`	1	--	ng5¹		26	NS MN CSAM EA NA EU WA	5977
	rs2069824^1,2	C,F,H,O	22731757(+)	`GAGTGT/CCTACG`	1	--	ng5¹		13	NS EU EA WA	2110
	rs2069827^1,2	C,F,H	22731981(+)	`TTATCG/TATCTT`	1	--	ng5¹ tfbs³		13	NS EU EA WA	2082
	rs1800796^1,2	C,F,H	22732771(+)	`CAGCCG/CCTCAC`	1	--	ng5¹		13	NS MN CSAM EA EU WA NA	990
	rs2069830^1,2	C,F,H	22733662(+)	`TACCCC/TCAGGA`	1	P/S	mis¹ ese³		7	NS EU EA WA NA	560
--	rs13306435^1,2	C,F,H	22737564(+)	`CTAGAT/AGCAAT`	1	E/D	mis¹		14	MN CSAM EA EU WA NA	1278
	rs2069861^1,2	C,F,H	22738179(+)	`ATAAAC/TAAGTT`	1	--	ng3¹		12	NS EU EA WA NA	1884
	rs2069860^1,2	C,F,H	22737563(+)	`TCTAGA/TWGCAA`	1	D/V	mis¹		19	NS NA MN CSAM EA EU WA	1663
	rs2069851^1,2	C,F,H	22737829(+)	`TGAGCG/ATTAGG`	1	--	ut3¹		9	NS NA EU EA WA	648
	rs1800797^1,2	C,F,H	22732746(+)	`TGAGGG/ATGGCC`	1	--	ng5¹		13	NS MN CSAM EA EU WA NA	1122

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HapMap Linkage Disequilibrium images for IL6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147620 disorders: 604302 148000 125853 108010 266600

UniProtKB/Swiss-Prot: IL6_HUMAN, P05231

Genetic variations in IL6 are associated with susceptibility to systemic juvenile

rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic

arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal

complications. Despite medical treatment, many children still experience early joint destruction,

necessitating surgical replacement

At least 1 polymorphism in the IL6 gene renders HIV-infected men susceptible to Kaposi

sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue.

A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or

plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS

10/95 Novoseek disease relationships for IL6 gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	95.39	11879	9290459 (7), 15105666 (7), 8855783 (6), 17173645 (6) (see all 99)
inflammation	90.68	1983	15935563 (5), 17374166 (5), 16518702 (5), 17130257 (4) (see all 99)
response acute phase	88.79	575	10080883 (5), 7512810 (4), 1883959 (3), 17703320 (3) (see all 99)
tumors	88.42	11071	15185009 (8), 10375098 (7), 9290459 (7), 15105666 (7) (see all 99)
myeloma	80.42	1090	10691869 (9), 1954351 (6), 15809207 (6), 15570293 (5) (see all 99)
systemic inflammatory response syndrome	79.15	98	15641601 (3), 8379598 (3), 10521088 (2), 10966252 (2) (see all 64)
rheumatoid arthritis	78.56	535	7944637 (6), 16582692 (5), 9410434 (4), 18419107 (3) (see all 99)
sepsis	76.11	685	16635168 (7), 8797615 (6), 11975924 (6), 11421413 (5) (see all 99)
castleman disease	71.67	126	18784373 (4), 9462253 (3), 17075601 (2), 19270642 (2) (see all 77)
shock septic	71.12	212	9366763 (10), 8797615 (6), 12352031 (5), 1292890 (4) (see all 99)

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6 PharmGKB disease relationships for IL6 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Arthritis, Juvenile Rheumatoid	CO FA GN	9769329
Cardiovascular Diseases	CO GN	11472429
Coronary Arteriosclerosis	CO GN	11472429
Coronary Disease	CO GN	11472429
Heart Failure, Congestive	CO GN	11472429
Inflammation	CO GN	11472429 11404167

About this table

Human Gene Mutation Database: IL6
Genetic Association Database: IL6
Human Genome Epidemiology Navigator: IL6 (879 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/8983 PubMed articles for IL6 gene (see all 8983 ):

The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. (PubMed id 9769329)^{1, 4, 6, 7} Fishman D.... Woo P. (1998)
A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density. (PubMed id 11355017)^{1, 3, 4, 6} Ota N.... Emi M. (2001)
The effect of cytokine gene polymorphisms on pediatric heart allograft outcome. (PubMed id 11404167)^{3, 6, 7} Awad M.R....Zeevi A. (2001)
The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults. (PubMed id 11282548)^{1, 3, 6} Kilpinen S....Hurme M. (2001)
Interleukin-10, interleukin-6 and interferon-gamma gene polymorphisms in melanoma patients. (PubMed id 12394188)^{1, 3, 6} Martinez-Escribano J.A....Alvarez-Lopez M.R. (2002)
Polymorphism of cytokine genes (TGF-beta1, IFN-gamma, IL-6, IL-10, and TNF-alpha) in patients with chronic pancreatitis. (PubMed id 15841043)^{1, 3, 6} Bendicho M.T....Lemaire D.C. (2005)
The interleukin-6 G(-174)C polymorphism and the ex vivo interleukin-6 response to endotoxin in severely injured blunt trauma patients. (PubMed id 11956023)^{1, 3, 6} Heesen M....Majetschak M. (2002)
Profound bias in interferon-gamma and interleukin-6 allele frequencies in western Kenya, where severe malarial anemia is common in children. (PubMed id 12232842)^{1, 3, 6} Gourley I.S....Duffy P.E. (2002)
Interleukin-6 and interferon-gamma gene polymorphisms in the development of bronchiolitis obliterans syndrome after lung transplantation. (PubMed id 12451269)^{1, 3, 6} Lu K.C....Mohanakumar T. (2002)
TNF-alpha, IL-6, IFN-gamma, and IL-10 gene expression polymorphisms and the IL-4 receptor alpha-chain variant Q576R: effects on renal allograft outcome. (PubMed id 11544427)^{1, 3, 6} Hahn A.B....Conti D.J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3569	HGNC: 6018	AceView: IL6	Ensembl:ENSG00000136244	euGenes: HUgn3569
ECgene: IL6	H-InvDB: IL6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for IL6	Genetics and Cytogenetics in Oncology and Haematology
R&D Systems' cytokine mini-reviews: IL-6	http://www.rndsystems.com/molecule_detail.aspx?m=1648
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_6
SeattleSNPs	http://pga.gs.washington.edu/data/il6/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL6

Licensable Technologies for IL6
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for IL6 gene:

Weizmann Institute:

Enrichment of Repopulating Stem Cells For Clinical Protocols

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IL6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IL6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IL6		Antibodies for IL6
	Explore super-pooled esiRNAs		Proteins for IL6
	Lentivirus-delivered shRNAs for IL6		Small molecules for IL6
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IL6)
	Search for Antibodies
	Chimera RNAi (IL6)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (IL6)
	Antibodies (IL6)

Search OriGene for IL6

Search Tocris compounds for IL6

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IL6

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
IL6 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

IL6 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for IL6

Summaries
for IL6

Genomic Location
for IL6

Proteins
for IL6

Protein Domains/
Families
for IL6

Gene Function
for IL6

Pathways & Interactions
for IL6

Drugs & Compounds
for IL6

Transcripts
for IL6

Expression
for IL6

Orthologs
for IL6

Paralogs
for IL6

SNPs/Variants
for IL6

Disorders & Mutations
for IL6

Medical News
for IL6

Publications
for IL6

Search for IL6

Genome Databases showing IL6

Other Databases showing IL6

Specialized Databases showing IL6

Licensable Technologies
for IL6

Services
for IL6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IL6 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor IL6

Summariesfor IL6

Genomic Locationfor IL6

Proteinsfor IL6

Protein Domains/Familiesfor IL6

Gene Functionfor IL6

Pathways & Interactionsfor IL6

Drugs & Compoundsfor IL6

Transcriptsfor IL6

Expression for IL6

Orthologsfor IL6

Paralogsfor IL6

SNPs/Variantsfor IL6

Disorders & Mutationsfor IL6

Medical Newsfor IL6

Publicationsfor IL6

Search for IL6

Genome Databases showing IL6

Other Databases showing IL6

Specialized Databases showing IL6

Licensable Technologiesfor IL6

Servicesfor IL6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IL6

Summaries
for IL6

Genomic Location
for IL6

Proteins
for IL6

Protein Domains/
Families
for IL6

Gene Function
for IL6

Pathways & Interactions
for IL6

Drugs & Compounds
for IL6

Transcripts
for IL6

Expression
for IL6

Orthologs
for IL6

Paralogs
for IL6

SNPs/Variants
for IL6

Disorders & Mutations
for IL6

Medical News
for IL6

Publications
for IL6

Licensable Technologies
for IL6

Services
for IL6