Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL6 Gene

protein-coding   GIFtS: 73
GCID: GC07P022732

interleukin 6 (interferon, beta 2)


(Previous symbol: IFNB2)
 Explore 682 diseases affiliated with
IL6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IL6    

Aliases
for IL6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interleukin 6 (Interferon, Beta 2)1 2     BSF-22 3
IFNB21 2 3 5     CDF2 3
IL-61 2 3     IFN-Beta-21
BSF21 2 5     B-Cell Stimulatory Factor 22 3
HGF1 2 5     CTL Differentiation Factor2 3
HSF1 2 5     B-Cell Differentiation Factor2
Hybridoma Growth Factor2 3     Interleukin BSF-22
Interferon Beta-22 3     Interleukin-61

External Ids:    HGNC: 60181   Entrez Gene: 35692   Ensembl: ENSG000001362447   OMIM: 1476205   UniProtKB: P052313   

Export aliases for IL6 gene to outside databases

Previous GC identifers: GC07P022409 GC07P022509 GC07P022540


Summaries
for IL6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IL6:
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded
protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or
infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into
the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning
of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to
diabetes mellitus and systemic juvenile rheumatoid arthritis. (provided by RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: IL6_HUMAN, P05231
Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response.
Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and
monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on
B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is
discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve
insulin resistance

summary for IL6:
MET (Mesenchymal epithelial transition factor), also known as hepatocyte growth factor receptor (HGFR) is a
proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter
factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the
adult, MET expression is limited to stem and progenitor cells and is necessary for wound healing and
hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are
essential for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abberant activation of
the HGF/MET pathway leads to a variety of cancers. MET mutation is associated with a poor prognosis as it
can trigger tumor growth, angiogenesis and metastasis.

Gene Wiki entry for IL6 (Interleukin 6)


Genomic Views
for IL6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL6 gene promoter:
         GR   C/EBPbeta   Nkx2-2   GR-beta   YY1   IRF-2   FOXJ2 (long isoform)   STAT3   FOXJ2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL6 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p21-p15

IL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P022732:  view genomic region     (about GC identifiers)

Start:
 22,765,503 bp from pter      End:
 22,771,621 bp from pter
Size:
 6,119 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 22,817,875-22,822,730     

Proteins
for IL6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IL6_HUMAN, P05231 (See protein sequence)
Recommended Name: Interleukin-6 precursor  
Size: 212 amino acids; 23718 Da
Subcellular location: Secreted
5 PDB 3D structures from and Proteopedia for IL6:
1ALU (3D)        1IL6 (3D)        1N2Q (3D)        1P9M (3D)        2IL6 (3D)    
Secondary accessions: Q9UCU2 Q9UCU3 Q9UCU4

Explore the universe of human proteins at neXtProt for IL6: NX_P05231

Post-translational modifications:

  • N- and O-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P05231

    • IL6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000591.1  
    ENSEMBL proteins: 
     ENSP00000385675   ENSP00000405150   ENSP00000385718   ENSP00000385043   ENSP00000384928  
     ENSP00000385227   ENSP00000258743   ENSP00000405994  
    Reactome Protein details: P05231
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant IL6 Protein
    R&D Systems Recombinant & Natural Proteins for IL6 (IL-6)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): IL6
    OriGene Protein Over-expression Lysate: IL6
    OriGene Custom Protein Services for IL6 
    GenScript Purified and Recombinant Proteins for IL6
    Novus Biologicals IL6 Proteins
    Novus Biologicals IL6 Lysates
    Sino Biological Recombinant Protein for IL6
    ProSpec Recombinant Protein for IL6
    Uscn Proteins for IL6

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA3023045
    GO:0005896interleukin-6 receptor complex IDA2261637
    GO:0009897external side of plasma membrane IEA--


    IL6 for ontologies           About GeneDecksing



    IL6 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL6
    R&D Systems Antibodies for IL6 (IL-6)
    OriGene Antibodies (see all 8): IL6
    OriGene Custom Antibody Services for IL6 
    GenScript Custom Superior Antibodies Services for IL6
    Novus Biologicals IL6 Antibodies
    Abcam antibodies for IL6 
    Uscn Antibodies for IL6
    ThermoFisher Antibody for IL6

    Assay Products for IL6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Flow Cytometry Kits for IL6 (IL-6)         (see all)
    GenScript Custom Assay Services for IL6
    Enzo Life Sciences assays for IL6
    Uscn ELISAs and CLIAs for IL6

    Protein Domains /
    Families
    for IL6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IL6 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR009079 4_helix_cytokine-like_core
     IPR003574 Interleukin_6
     IPR012351 4_helix_cytokine_core
     IPR003573 IL6_MGF_GCSF

    Graphical View of Domain Structure for InterPro Entry P05231

    ProtoNet protein and cluster: P05231

    1 Blocks protein family: IPB003574 Interleukin-6 signature

    UniProtKB/Swiss-Prot: IL6_HUMAN, P05231
    Similarity: Belongs to the IL-6 superfamily


    Function
    for IL6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IL6_HUMAN, P05231
    Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response.
    Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and
    monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on
    B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is
    discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve
    insulin resistance

         Genatlas biochemistry entry for IL6:
    interleukin 6,23.7kDa,involved in the regulation of immune response,hematopoiesis,platelet production,acute phase
    reaction and bone resorption (susceptibility factor for osteopenia),playing a role in the aggressiveness of non
    hodgkin lymphoma by stimulating MMP2 and MMP9

         Summary:  
    During embryonic development, IL6 as signaling molecule is secreted from the following cells: Sinusoidal Endothelial Cells in Sinusoids, Visceral White Adipocytes in Visceral White Adipose

    It affects the following cells: Hepatocytes in Liver Lobule

    IL6 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Erythroid progenitors, Erythroid-like cells (see all 10).

    miRNA
    Products:            		miRTarBase miRNAs that target IL6:
    hsa-let-7a (MIRT005420)

    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL6
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate IL6 (see all 14):
    hsa-miR-98 hsa-miR-676 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-548o hsa-let-7i hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmid: IL6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL6 (see all 7)
    OriGene shRNA RFP: IL6
    OriGene siRNA: IL6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IL6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL6 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IL6 (NM_000600)
    Sino Biological Human cDNA Clone for IL6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IL6
    Search LifeMap BioReagents cell lines for IL6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005125cytokine activity NAS10443688
    GO:0005138interleukin-6 receptor binding NAS1883960
    GO:0005515protein binding ----
    GO:0008083growth factor activity IDA2261637


    IL6 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for IL6: Il6tm1Poli Il6tm1Mur Il6tm1Kopf
         15/20 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Il6) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  muscle  nervous system 

    IL6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IL6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/70 super-pathways (see all 70) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2PEDF Induced Signaling
    8/12 pathways (see all 12)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    3GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    4Mucin expression in CF via IL-6, IL-17 signaling pathways
    		Mucin expression in CF via IL-6, IL-17 signaling pathways1.00
    		Cytokine production by Th17 cells in CF (Mouse model)0.37
    		Cytokine production by Th17 cells in CF0.45
    		Immune response_MIF-mediated glucocorticoid regulation0.28
    		Mucin expression in CF via TLRs, EGFR signaling pathways0.41
    		Immune response MIF-mediated glucocorticoid regulation0.28
    5TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/9 EMD Millipore Pathways for IL6 (see all 9)
        Transcription Androgen Receptor nuclear signaling
    Selected targets of GCR-alpha
    Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response
    Immune response IL-1 signaling pathway

    5 R&D Systems Pathways for IL6
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Adipocytokines & Insulin Signaling
    IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Toll-Like receptor Signaling Pathways
    Th17 Differentiation

    5/74 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL6 (see all 74)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    5/14 GeneGo (Thomson Reuters) Pathways for IL6 (see all 14)
        Immune response IL-6 signaling pathway
    Immune response MIF-mediated glucocorticoid regulation
    Transcription Androgen Receptor nuclear signaling
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response

    5/19 BioSystems Pathways for IL6 (see all 19) 
        SIDS Susceptibility Pathways
    Senescence and Autophagy
    Adipogenesis
    Cytokines and Inflammatory Response
    Myometrial Relaxation and Contraction Pathways

    5/7        Reactome Pathways for IL6 (see all 7)
        Interleukin-6 signaling
    Cytokine Signaling in Immune system
    Serine phosphorylation of STATs
    Signaling by Interleukins
    Phosphorylation of gp130


    5/20         Kegg Pathways  (Kegg details for IL6) (see all 20):
        Cytokine-cytokine receptor interaction
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway
    Cytosolic DNA-sensing pathway
    Jak-STAT signaling pathway


    IL6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for IL6 (P052312, 3 ENSP000002587434) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GL2Q999622, 3, ENSP000003699814MINT-63404 I2D: score=6 STRING: ENSP00000369981
    ZBTB16Q055162, 3, ENSP000003381574MINT-63403 I2D: score=4 STRING: ENSP00000338157
    IL6RP088873, ENSP000003574704I2D: score=5 STRING: ENSP00000357470
    IL6STP401893, ENSP000003387994I2D: score=5 STRING: ENSP00000338799
    PTHLHP122723, ENSP000003792134I2D: score=1 STRING: ENSP00000379213
    About this table

    Gene Ontology (GO): 5/98 biological process terms (GO ID links to tree view) (see all 98):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001781neutrophil apoptotic process IDA7595060
    GO:0002384hepatic immune response TAS12832423
    GO:0002446neutrophil mediated immunity IC16034137
    GO:0002548monocyte chemotaxis IC10510402
    GO:0002675positive regulation of acute inflammatory response IDA2444978


    IL6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IL6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for IL6

    Compounds for IL6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PHA 665752Potent and selective MET inhibitor[477575-56-7]
    K 252aProtein kinase inhibitor[99533-80-9]

    1 HMDB Compound for IL6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    1 DrugBank Compound for IL6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ginseng-- 50647-08-0targetantagonist14642426 17436372

    10/136 Novoseek chemical compound relationships for IL6 gene (see all 136)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 92 1249 7812050 (6), 9126968 (5), 1602143 (5), 8467812 (5) (see all 99)
    endotoxin 81.9 867 8243265 (7), 19669960 (7), 11990931 (6), 10499730 (6) (see all 99)
    rantes 81.3 612 16413378 (6), 16466762 (6), 19932032 (6), 12509950 (6) (see all 99)
    tocilizumab 78.8 109 18784373 (7), 16102523 (4), 17214583 (3), 18664393 (3) (see all 58)
    il 10 78.4 260 19084425 (6), 12394188 (5), 12719394 (5), 19199277 (4) (see all 99)
    pge2 76.3 1475 9556135 (9), 8520508 (8), 16145911 (6), 9160463 (6) (see all 99)
    vegf 74.3 1899 15840215 (11), 11753617 (10), 12147798 (9), 13129863 (9) (see all 99)
    neopterin 73.6 312 1933885 (6), 9243197 (6), 10211419 (5), 8844226 (4) (see all 99)
    fibrinogen 73.3 1127 16703188 (8), 10959691 (6), 16159604 (5), 20059469 (5) (see all 99)
    dexamethasone 67.9 779 9207463 (8), 11713366 (6), 8550757 (6), 10880513 (5) (see all 99)

    Search CenterWatch for drugs/clinical trials and news about IL6 

    Transcripts
    for IL6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IL6 gene: 
    NM_000600.3  

    Unigene Cluster for IL6:

    Interleukin 6 (interferon, beta 2)
    Hs.654458  [show with all ESTs]
    Unigene Representative Sequence: BM906445
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404625 ENST00000426291 ENST00000401651 ENST00000485300 ENST00000407492
    ENST00000401630 ENST00000406575 ENST00000464710 ENST00000258743(uc003svj.4)
    ENST00000420258(uc011jyo.1 uc011jyp.1 uc011jyq.1)

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL6
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate IL6 (see all 14):
    hsa-miR-98 hsa-miR-676 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-548o hsa-let-7i hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmid: IL6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL6 (see all 7)
    OriGene shRNA RFP: IL6
    OriGene siRNA: IL6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL6
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL6 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IL6 (NM_000600)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL6

    Additional cDNA sequence: 

    AK298013.1 AK298077.1 AK301141.1 BC015511.1 BT019748.1 BT019749.1 CR450296.1 M14584.1 
    M18403.1 M29150.1 M54894.1 S56892.1 X04403.1 X04430.1 X04602.1 

    7 DOTS entries:

    DT.212868  DT.91771152  DT.40189406  DT.85101821  DT.121119373  DT.40128177  DT.95261924 

    24/141 AceView cDNA sequences (see all 141):

    BM955891 CD743002 CA431676 BM996808 CA308013 AU102636 AI472218 CA307967 
    AI751501 BU196113 C21585 BU627371 CR626263 CA306986 AI632696 CA306629 
    CD013918 BX097268 AA362308 BQ102313 AI085963 AL544153 CD368463 M18403 

    GeneLoc Exon Structure


    Expression
    for IL6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCACCTCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IL6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeVisceral White AdipocytesAdipose
    BoneAutopod PeriosteumEndochondral OsteoblastsBone
    BoneCervical VertebraeEndochondral OsteoblastsBone
    BoneLumbar VertebraeEndochondral OsteoblastsBone
    BoneSacral VertebraeEndochondral OsteoblastsBone
    BoneStylopod PeriosteumEndochondral OsteoblastsBone
    BoneThoracic RibEndochondral OsteoblastsBone
    BoneThoracic VertebraeEndochondral OsteoblastsBone
    BoneZeugopod PeriosteumEndochondral OsteoblastsBone
    Early Embryo (Zygote)ZygoteZygoteEarly Embryo
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Mesenchymal Precursor Cells (STRO-3 selected) (Adult Stem / Progenitor Cell)Bone
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    Fetal cardiomyocytes (20 weeks) (Primary Cell)Heart, Myocardium

    See IL6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL6

    SOURCE GeneReport for Unigene cluster: Hs.654458
        SABiosciences Expression via Pathway-Focused PCR Arrays including IL6 (see all 45): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              Lymphoma in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6

    Orthologs
    for IL6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IL6 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Il61 , 5 interleukin 61, 5 61.24(n)1
    41.63(a)1    		   5 (15.70 cM)5
    161931  NM_031168.11  NP_112445.11 
     300131615 
    chicken
    (Gallus gallus)    		 Aves IL61 interleukin 6 (interferon, beta 2) 54.33(n)
    40(a)    		   395337  NM_204628.1  NP_989959.1 


    ENSEMBL Gene Tree for IL6 (if available)
    TreeFam Gene Tree for IL6 (if available) 

    Paralogs
    for IL6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for IL6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: IL6_HUMAN, P05231
    Polymorphism: Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for
    osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone
    microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic
    bones are more at risk of fracture


    10/282 NCBI SNPs in IL6 are shown (see all 282)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs751998311,2
    		C,F,--22764848(+) CAAACA/GGCTGG 2 -- ds5001 us2k11Minor allele frequency- G:0.03EA 120
    rs1429302531,2
    		--22764868(+) AAAACA/CTTTCC 2 -- ds5001 us2k10--------
    rs1859461441,2
    		--22764918(+) AATTAA/GGTGCT 2 -- ds5001 us2k10--------
    rs1140248711,2
    		--22764956(+) AAGGAG/AACACT 2 -- ds5001 us2k11Minor allele frequency- A:0.01WA 118
    rs1483604891,2
    		--22765001(+) TTTATC/TATGAA 2 -- us2k1 ds50010--------
    rs1903178821,2
    		--22765169(+) GTGCAC/TGGCTG 2 -- us2k1 nc-transcript-variant0--------
    rs1415719131,2
    		--22765237(+) TCTACA/GTTGCT 2 -- nc-transcript-variantus2k10--------
    rs1509174691,2
    		--22765243(+) TTGCTC/TAAGAC 2 -- nc-transcript-variantus2k10--------
    rs350817821,2
    		C,--22765336(+) CACCG-/TCTCTCT 2 -- nc-transcript-variantus2k10--------
    rs2011994361,2
    		C--22765796(+) CAAATA/CAAGAC 2 -- us2k1 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for IL6 (22765503 - 22771621 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IL6
         1 CNV: 3670
    Human Gene Mutation Database (HGMD): IL6

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL6
    DNA2.0 Custom Variant and Variant Library Synthesis for IL6

    Disorders / Diseases
    for IL6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IL6 for disorders           About GeneDecksing

    OMIM gene information: 147620   
    OMIM disorders: 604302  148000  125853  108010  266600  
    UniProtKB/Swiss-Prot: IL6_HUMAN, P05231
  • Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ)
    • [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a
    subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications.
    During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash,
    lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis
  • Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in
    • HIV-infected men

    20/682 diseases for IL6 (see all 682):    About MalaCards
    charcot-marie-tooth neuropathy    charcot-marie-tooth neuropathy type 2    juvenile rheumatoid arthritis    rheumatoid arthritis
    charcot-marie-tooth neuropathy type 2a    diabetes mellitus    carotid intimal medial thickness    crimean-congo hemorrhagic fever
    hyper-ige syndrome    intracranial hemorrhage in brain cerebrovascular malformations    post-transplant lymphoproliferative disease    monoclonal gammopathy of uncertain significance
    polyclonal hypergammaglobulinemia    arthritis    monoclonal gammopathy of undetermined significance    perinatal necrotizing enterocolitis
    vibrio vulnificus infection    benign migratory glossitis    zollinger-ellison syndrome    rheumatoid arthritis, systemic juvenile

    20/54 diseases from the University of Copenhagen DISEASES database for IL6 (see all 54):
    Arthritis     Vascular disease     Lung disease     Multiple myeloma
    Heart disease     Diabetes mellitus     Hypersensitivity reaction type II disease     Kidney disease
    Connective tissue disease     Inflammatory bowel disease     Periodontitis     Brain disease
    Pancreatitis     Chorioamnionitis     Skin disease     Peritonitis
    Liver disease     Lymphoma     Osteoporosis     Anemia

    10/95 Novoseek disease relationships for IL6 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 95.5 13028 9290459 (7), 15105666 (7), 8855783 (6), 17173645 (6) (see all 99)
    inflammation 91.5 2296 15935563 (5), 17374166 (5), 16518702 (5), 17130257 (4) (see all 99)
    tumors 88.6 12141 15185009 (8), 10375098 (7), 9290459 (7), 15105666 (7) (see all 99)
    response acute phase 88.5 588 10080883 (5), 7512810 (4), 1883959 (3), 17703320 (3) (see all 99)
    systemic inflammatory response syndrome 80 106 15641601 (3), 8379598 (3), 10521088 (2), 10966252 (2) (see all 69)
    myeloma 79.8 1104 10691869 (9), 1954351 (6), 15809207 (6), 15570293 (5) (see all 99)
    rheumatoid arthritis 79.5 588 7944637 (6), 16582692 (5), 9410434 (4), 18419107 (3) (see all 99)
    sepsis 76.9 740 16635168 (7), 8797615 (6), 11975924 (6), 11421413 (5) (see all 99)
    insulin resistance 72.3 423 19188739 (5), 12952969 (4), 18991689 (3), 17322479 (3) (see all 99)
    castleman disease 71.9 137 18784373 (4), 9462253 (3), 17075601 (2), 19270642 (2) (see all 86)

    Genetic Association Database (GAD): IL6
    Human Genome Epidemiology (HuGE) Navigator: IL6 (1228 documents)

    Export disorders for IL6 gene to outside databases

    Publications
    for IL6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL6 gene, integrated from 9 sources (see all 11992):
    (articles sorted by number of sources associating them with IL6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density. (PubMed id 11355017)1, 2, 4, 9 Ota N.... Emi M. (2001)
    2. The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults. (PubMed id 11282548)1, 4, 9 Kilpinen S....Hurme M. (2001)
    3. Interleukin-10, interleukin-6 and interferon-gamma gene polymorphisms in melanoma patients. (PubMed id 12394188)1, 4, 9 Martinez-Escribano J.A....Alvarez-Lopez M.R. (2002)
    4. Polymorphism of cytokine genes (TGF-beta1, IFN-gamma, IL-6, IL-10, and TNF-alpha) in patients with chronic pancreatitis. (PubMed id 15841043)1, 4, 9 Bendicho M.T....Lemaire D.C. (2005)
    5. The interleukin-6 G(-174)C polymorphism and the ex vivo interleukin-6 response to endotoxin in severely injured blunt trauma patients. (PubMed id 11956023)1, 4, 9 Heesen M....Majetschak M. (2002)
    6. Profound bias in interferon-gamma and interleukin-6 allele frequencies in western Kenya, where severe malarial anemia is common in children. (PubMed id 12232842)1, 4, 9 Gourley I.S....Duffy P.E. (2002)
    7. Interleukin-6 and interferon-gamma gene polymorphisms in the development of bronchiolitis obliterans syndrome after lung transplantation. (PubMed id 12451269)1, 4, 9 Lu K.C....Mohanakumar T. (2002)
    8. TNF-alpha, IL-6, IFN-gamma, and IL-10 gene expression polymorphisms and the IL-4 receptor alpha-chain variant Q576R: effects on renal allograft outcome. (PubMed id 11544427)1, 4, 9 Hahn A.B....Conti D.J. (2001)
    9. Polymorphisms of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-10, and IL-18 and the risk of ovarian cancer. (PubMed id 15581980)1, 4, 9 Bushley A.W....Goodman M.T. (2004)
    10. The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing. (PubMed id 15050298)1, 4, 9 Giacconi R....Mocchegiani E. (2004)

    External Searches for IL6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IL6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3569 HGNC: 6018 AceView: IL6 Ensembl:ENSG00000136244 euGenes: HUgn3569
    ECgene: IL6 Kegg: 3569 H-InvDB: IL6

    Other Databases showing IL6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IL6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL6 Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine mini-reviews: IL-6http://www.rndsystems.com/molecule_detail.aspx?m=1648
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_6
    SeattleSNPshttp://pga.gs.washington.edu/data/il6/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL6

    Intellectual Property
    for IL6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IL6 gene:
    Search GeneIP for patents involving IL6

    Licensable Technologies for IL6 gene:
    Weizmann Institute:Enrichment of Repopulating Stem Cells For Clinical Protocols
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IL6 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of IL6
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Purified and/or Recombinant IL6 Protein
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for IL6 (IL-6)   Browse Cell Culture Products  
     ELISAs for IL6 (IL-6)   Flow Cytometry Kits for IL6 (IL-6)  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules for IL6 (IL-6)   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for IL6 (IL-6)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for IL6 (IL-6)  
     OriGene Antibodies for IL6   OriGene shRNA RFP for IL6  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL6   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL6  
     OriGene Protein Over-expression Lysate for IL6   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for IL6   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL6   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL6  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for IL6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IL6   OriGene Custom Protein Services for IL6  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL6
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL6
     GenScript Purified and Recombinant Proteins for IL6 GenScript cDNA clones with any tag delivered in your preferred vector for IL6
     GenScript Custom Assay Services for IL6 GenScript Custom Superior Antibodies Services for IL6
     GenScript Custom overexpressing Cell Line Services for IL6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IL6 promoter
     Search Chromatin IP Primers for IL6
     RT2 qPCR Primer Assay in human, mouse, rat IL6
     GNC Network for IL6
     SABiosciences PCR Arrays including human, mouse, rat IL6
     Tocris compounds for IL6
     Proteins and Antibodies for IL6
     cDNA Clones for IL6
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Assays/Drugs for IL6
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IL6 antibodies
     IL6 proteins
     IL6 lysates
     Antibodies for IL6
     See all of Abcam's Antibodies, Kits and Proteins for IL6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for IL6




     IL6 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for IL6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6
     SwitchGear 3'UTR luciferase reporter plasmids for IL6
     SwitchGear Promoter luciferase reporter plasmids for IL6
     ThermoFisher Antibody for IL6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      IL6 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4