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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL6 Gene

protein-coding   GIFtS: 72
GCID: GC07P022732

Interleukin 6 (Interferon, Beta 2)


(Previous symbol: IFNB2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 6 (Interferon, Beta 2)1 2     B-Cell Stimulatory Factor 22 3
IFNB21 2 3 5     CTL Differentiation Factor2 3
Hybridoma Growth Factor2 3     BSF22 5
Interferon Beta-22 3     HGF2 5
BSF-22 3     HSF2 5
CDF2 3     B-Cell Differentiation Factor2
IFN-beta-22 3     Interleukin BSF-22
IL-62 3     interleukin-62

External Ids:    HGNC: 60181   Entrez Gene: 35692   Ensembl: ENSG000001362447   OMIM: 1476205   UniProtKB: P052313   

Export aliases for IL6 gene to outside databases

Previous GC identifers: GC07P022409 GC07P022509 GC07P022540


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL6 Gene:
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the
encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune
diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is
secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor,
alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states,
including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. (provided by RefSeq,
Jun 2011)

GeneCards Summary for IL6 Gene: 
IL6 (interleukin 6 (interferon, beta 2)) is a protein-coding gene. Diseases associated with IL6 include castleman's disease, and multicentric castleman disease, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Toll-like receptor signaling pathway. GO annotations related to this gene include growth factor activity and interleukin-6 receptor binding.

UniProtKB/Swiss-Prot: IL6_HUMAN, P05231
Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase
response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in
lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells
differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also
acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the
breakdown of fats and to improve insulin resistance

summary for IL6 Gene:
MET (Mesenchymal epithelial transition factor), also known as hepatocyte growth factor receptor (HGFR) is a
proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter
factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the
adult, MET expression is limited to stem and progenitor cells and is necessary for wound healing and
hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are
essential for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abberant activation of
the HGF/MET pathway leads to a variety of cancers. MET mutation is associated with a poor prognosis as it
can trigger tumor growth, angiogenesis and metastasis.

Gene Wiki entry for IL6 (Interleukin 6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL6 gene promoter:
         GR   C/EBPbeta   Nkx2-2   GR-beta   YY1   IRF-2   FOXJ2 (long isoform)   STAT3   FOXJ2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL6 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p21-p15

IL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P022732:  view genomic region     (about GC identifiers)

Start:
22,765,503 bp from pter      End:
22,771,621 bp from pter
Size:
6,119 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 22,817,875-22,822,730     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL6_HUMAN, P05231 (See protein sequence)
Recommended Name: Interleukin-6 precursor  
Size: 212 amino acids; 23718 Da
Subcellular location: Secreted
5 PDB 3D structures from and Proteopedia for IL6:
1ALU (3D)        1IL6 (3D)        1N2Q (3D)        1P9M (3D)        2IL6 (3D)    
Secondary accessions: Q9UCU2 Q9UCU3 Q9UCU4

Explore the universe of human proteins at neXtProt for IL6: NX_P05231

Explore proteomics data for IL6 at MOPED 

Post-translational modifications:

  • UniProtKB: N- and O-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P05231

  • IL6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL6 Protein Expression
    REFSEQ proteins: NP_000591.1  
    ENSEMBL proteins: 
     ENSP00000385675   ENSP00000405150   ENSP00000385718   ENSP00000385043   ENSP00000384928  
     ENSP00000385227   ENSP00000258743   ENSP00000405994  
    Reactome Protein details: P05231
    Human Recombinant Protein Products for IL6: 
    EMD Millipore Purified and/or Recombinant IL6 Protein
    R&D Systems Recombinant & Natural Proteins for IL6 (IL-6)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IL6
    OriGene Protein Over-expression Lysate for IL6
    OriGene MassSpec for IL6 
    OriGene Custom Protein Services for IL6
    GenScript Purified and Recombinant Proteins for IL6
    Novus Biologicals IL6 Proteins
    Novus Biologicals IL6 Lysates
    Sino Biological Recombinant Protein for IL6
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for IL6
    Cloud-Clone Corp. Proteins for IL6 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA10443688
    GO:0005896interleukin-6 receptor complex IDA12829785
    GO:0009897external side of plasma membrane IEA--

    IL6 for ontologies           About GeneDecksing



    IL6 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL6
    R&D Systems Antibodies for IL6 (IL-6)
    OriGene Antibodies for IL6
    OriGene Custom Antibody Services for IL6
    GenScript Custom Superior Antibodies Services for IL6
    Novus Biologicals IL6 Antibodies
    Abcam antibodies for IL6
    Cloud-Clone Corp. Antibodies for IL6 
    ThermoFisher Antibody for IL6
    LSBio Antibodies in human, mouse, rat for IL6 

    Assay Products for IL6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL6
    R&D Systems Flow Cytometry Kits for IL6 (IL-6)         (see all)
    GenScript Custom Assay Services for IL6
    Enzo Life Sciences assays for IL6
    Cloud-Clone Corp. ELISAs for IL6 
    Cloud-Clone Corp. CLIAs for IL6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFN: Interferons
    IL: Interleukins and interleukin receptors

    4 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core
     IPR003574 Interleukin_6
     IPR003573 IL6_MGF_GCSF

    Graphical View of Domain Structure for InterPro Entry P05231

    ProtoNet protein and cluster: P05231

    1 Blocks protein domain: IPB003574 Interleukin-6 signature

    UniProtKB/Swiss-Prot: IL6_HUMAN, P05231
    Similarity: Belongs to the IL-6 superfamily


    IL6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL6_HUMAN, P05231
    Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase
    response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in
    lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells
    differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also
    acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the
    breakdown of fats and to improve insulin resistance

         Genatlas biochemistry entry for IL6:
    interleukin 6,23.7kDa,involved in the regulation of immune response,hematopoiesis,platelet production,acute phase
    reaction and bone resorption (susceptibility factor for osteopenia),playing a role in the aggressiveness of non
    hodgkin lymphoma by stimulating MMP2 and MMP9

         Summary:
    During embryonic development, IL6 as signaling molecule is secreted from the following cells: Sinusoidal Endothelial Cells in Sinusoids, Visceral White Adipocytes in Visceral White Adipose

    It affects the following cells: Hepatocytes in Liver Lobule

    IL6 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Mast-like cells from Blood, Erythroid-like cells from Blood (see all).

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005125cytokine activity NAS10443688
    GO:0005138interleukin-6 receptor binding NAS1883960
    GO:0005515protein binding ----
    GO:0008083growth factor activity IDA12643274
         
    IL6 for ontologies           About GeneDecksing


    Phenotypes:
         15/20 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il6) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  muscle  nervous system 

    IL6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL6: Il6tm1Poli Il6tm1Mur Il6tm1Kopf

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL6 

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL6:
    hsa-let-7a (MIRT005420)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL6
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate IL6 (see all 14):
    hsa-miR-98 hsa-miR-676 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-548o hsa-let-7i hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidIL6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL6
    Sirion Biotech Customized adenovirus for overexpression of IL6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IL6 (see all 7)
    OriGene ORF clones in mouse, rat for IL6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL6 (NM_000600)
    Sino Biological Human cDNA Clone for IL6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6
    Sirion Biotech Customized lentivirus for stable overexpression of IL6 
                         Customized lentivirus expression plasmids for stable overexpression of IL6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL6
    Search LifeMap BioReagents cell lines for IL6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL6 About   (see all 82)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Chagas disease (American trypanosomiasis)0.33
    Toll-like receptor signaling pathway0.93
    Hepatitis B0.31
    3Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    4Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    5GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 EMD Millipore Pathways for IL6 (see all 9)
        Transcription Androgen Receptor nuclear signaling
    Selected targets of GCR-alpha
    Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response
    Immune response IL-1 signaling pathway

    5/6 R&D Systems Pathways for IL6 (see all 6)
        NOD-like Receptor Signaling Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Adipocytokines & Insulin Signaling
    IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Toll-Like receptor Signaling Pathways

    5/74 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL6 (see all 74)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    5/14 GeneGo (Thomson Reuters) Pathways for IL6 (see all 14)
        Immune response IL-6 signaling pathway
    Immune response MIF-mediated glucocorticoid regulation
    Transcription Androgen Receptor nuclear signaling
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response

    5/20 BioSystems Pathways for IL6 (see all 20)
        Myometrial Relaxation and Contraction Pathways
    Cytokines and Inflammatory Response
    Senescence and Autophagy
    Adipogenesis
    SIDS Susceptibility Pathways


    4        Reactome Pathways for IL6
        Interleukin-6 signaling
    Cytokine Signaling in Immune system
    Signaling by Interleukins
    Immune System


    5/31         Kegg Pathways  (Kegg details for IL6) (see all 31):
        Cytokine-cytokine receptor interaction
    HIF-1 signaling pathway
    PI3K-Akt signaling pathway
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway


    IL6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for IL6 (P052312, 3 ENSP000002587434) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GL2Q999622, 3, ENSP000003699814MINT-63404 I2D: score=6 STRING: ENSP00000369981
    ZBTB16Q055162, 3, ENSP000003381574MINT-63403 I2D: score=4 STRING: ENSP00000338157
    IL6RP088873, ENSP000003574704I2D: score=5 STRING: ENSP00000357470
    IL6STP401893, ENSP000003387994I2D: score=5 STRING: ENSP00000338799
    PTHLHP122723, ENSP000003792134I2D: score=1 STRING: ENSP00000379213
    About this table

    Gene Ontology (GO): 5/97 biological process terms (GO ID links to tree view) (see all 97):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001781neutrophil apoptotic process IDA7595060
    GO:0002384hepatic immune response TAS12832423
    GO:0002446neutrophil mediated immunity IC16034137
    GO:0002548monocyte chemotaxis IC10510402
    GO:0002675positive regulation of acute inflammatory response IDA2444978

    IL6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for IL6

    Compounds for IL6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CrizotinibPotent c-MET/ALK inhibitor[877399-52-5]
    PF 04217903 mesylateHighly selective c-Met inhibitor[956906-93-7]
    PHA 665752Potent and selective MET inhibitor[477575-56-7]
    SU 11274Selective inhibitor of MET kinase activity[658084-23-2]

    1 HMDB Compound for IL6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    1 DrugBank Compound for IL6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ginseng-- 50647-08-0targetantagonist14642426 17436372

    10/136 Novoseek inferred chemical compound relationships for IL6 gene (see all 136)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 92 1249 7812050 (6), 9126968 (5), 1602143 (5), 8467812 (5) (see all 99)
    endotoxin 81.9 867 8243265 (7), 19669960 (7), 11990931 (6), 10499730 (6) (see all 99)
    rantes 81.3 612 16413378 (6), 16466762 (6), 19932032 (6), 12509950 (6) (see all 99)
    tocilizumab 78.8 109 18784373 (7), 16102523 (4), 17214583 (3), 18664393 (3) (see all 58)
    il 10 78.4 260 19084425 (6), 12394188 (5), 12719394 (5), 19199277 (4) (see all 99)
    pge2 76.3 1475 9556135 (9), 8520508 (8), 16145911 (6), 9160463 (6) (see all 99)
    vegf 74.3 1899 15840215 (11), 11753617 (10), 12147798 (9), 13129863 (9) (see all 99)
    neopterin 73.6 312 1933885 (6), 9243197 (6), 10211419 (5), 8844226 (4) (see all 99)
    fibrinogen 73.3 1127 16703188 (8), 10959691 (6), 16159604 (5), 20059469 (5) (see all 99)
    dexamethasone 67.9 779 9207463 (8), 11713366 (6), 8550757 (6), 10880513 (5) (see all 99)

    Search CenterWatch for drugs/clinical trials and news about IL6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL6 gene: 
    NM_000600.3  

    Unigene Cluster for IL6:

    Interleukin 6 (interferon, beta 2)
    Hs.654458  [show with all ESTs]
    Unigene Representative Sequence: BM906445
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404625 ENST00000426291 ENST00000401651 ENST00000485300 ENST00000407492
    ENST00000401630 ENST00000406575 ENST00000464710 ENST00000258743(uc003svj.4)
    ENST00000420258(uc011jyo.1 uc011jyp.1 uc011jyq.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL6
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate IL6 (see all 14):
    hsa-miR-98 hsa-miR-676 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-548o hsa-let-7i hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidIL6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL6
    Clone
    Products:
         
    OriGene clones in human, mouse for IL6 (see all 7)
    OriGene ORF clones in mouse, rat for IL6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL6 (NM_000600)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6
    Sirion Biotech Customized lentivirus for stable overexpression of IL6 
                         Customized lentivirus expression plasmids for stable overexpression of IL6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL6
    OriGene qSTAR qPCR primer pairs in human, mouse for IL6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL6

    Additional mRNA sequence: 

    AK298013.1 AK298077.1 AK301141.1 BC015511.1 BT019748.1 BT019749.1 CR450296.1 M14584.1 
    M18403.1 M29150.1 M54894.1 S56892.1 X04403.1 X04430.1 X04602.1 

    7 DOTS entries:

    DT.212868  DT.91771152  DT.40189406  DT.85101821  DT.121119373  DT.40128177  DT.95261924 

    24/141 AceView cDNA sequences (see all 141):

    BQ086151 AW134707 CA431676 CR590965 BU627371 AW966001 CR450296 AI085963 
    X04403 AI472218 CA308665 CA308013 BE786701 BU196113 AL544153 AU098441 
    CD743002 M18403 CD368463 CA306629 BM675188 CA306986 CD367420 CA306654 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL6 expression in normal human tissues (normalized intensities)      IL6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCACCTCAG
    IL6 Expression
    About this image


    IL6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 11 entries
             Endochondral Osteoblasts Autopod Periosteum
             GLP-transfected mesenchymal stem cells
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Mature Cardiac Fibroblasts Myocardium
             Coronary Artery Smooth Muscle Cells (CASMC)   
             Cardiac Myocytes   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 4 entries
             Mesenchymal Stem Cells Wharton's Jelly
             Wharton's jelly-derived stem cells
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Mesenchymal Stem Cells
             Decidua-derived mesenchymal stem cells
             Human Mesenchymal Stem Cell-hepatic (HMSC-he)   
     
     Uncategorized (Uncategorized)    fully expand to see all 3 entries
             PureStem progenitor F15

    See IL6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL6

    SOURCE GeneReport for Unigene cluster: Hs.654458
        SABiosciences Expression via Pathway-Focused PCR Arrays including IL6 (see all 45): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              Lymphoma in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL6
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL6 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il61 , 5 interleukin 61, 5 61.24(n)1
    41.63(a)1
      5 (15.70 cM)5
    161931  NM_031168.11  NP_112445.11 
     300131615 
    chicken
    (Gallus gallus)
    Aves IL61 interleukin 6 (interferon, beta 2) 54.33(n)
    40(a)
      395337  NM_204628.1  NP_989959.1 
    lizard
    (Anolis carolinensis)
    Reptilia IL66
    interleukin 6 (interferon, beta 2)
    29(a)
    1 ↔ 1
    6(30304240-30310770)


    ENSEMBL Gene Tree for IL6 (if available)
    TreeFam Gene Tree for IL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: IL6_HUMAN, P05231
    Polymorphism: Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk
    factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of
    bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone.
    Osteoporotic bones are more at risk of fracture


    10/107 SNPs in IL6 are shown (see all 107)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0130754
    ----see VAR_0130752 P S mis40--------
    rs1828128601,2
    C--22743305(+) ATCCAC/GTTCCT 2 H Q mis10--------
    rs2010240111,2
    --22743338(+) TCATTC/TCCTCA 1 -- int10--------
    rs2007172931,2
    --22743342(+) TCCCTC/TAACTT 1 -- int10--------
    rs20698421,2
    C,F,A,H--22743351(+) TTGGTG/ATGGGG 1 -- int127Minor allele frequency- A:0.04NS MN EA NA WA CSA 3352
    rs1438081441,2
    --22743405(+) AATGCC/TACTTC 1 -- int10--------
    rs1166939671,2
    F--22743428(+) CTACAC/TGTAAA 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1472392501,2
    --22743558(+) GAGGTA/GGATTT 1 -- int10--------
    rs1995006901,2
    --22743606(+) AAGGC-/GGGGGG 1 -- int10--------
    rs1856813771,2
    --22743616(+) GGGCGA/GGCAGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for IL6 (22765503 - 22771621 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL6:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2070e1CNV Complex17122850
    nsv7393OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): IL6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL6
    DNA2.0 Custom Variant and Variant Library Synthesis for IL6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147620   
    OMIM disorders: 604302  148000  125853  108010  266600  
    UniProtKB/Swiss-Prot: IL6_HUMAN, P05231
  • Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with
    systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with
    severe extraarticular features and occasionally fatal complications. During active phases of the disorder,
    patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly,
    serositis, myalgia and arthritis. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry
  • Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in
    HIV-infected men

  • 20/636 diseases for IL6 (see all 636):    About MalaCards
    castleman's disease    multicentric castleman disease    plasmacytoma    localized castleman disease
    polyclonal hypergammaglobulinemia    acute cystitis    intracranial hemorrhage in brain cerebrovascular malformations    crohn disease-associated growth failure
    kaposi's sarcoma    juvenile rheumatoid arthritis    amyloidosis aa    vibrio vulnificus infection
    cyclic vomiting syndrome    benign migratory glossitis    acute adrenal insufficiency    rheumatoid arthritis
    peritonitis    poems syndrome    euthyroid sick syndrome    complex regional pain syndrome type 1

    20/36 diseases from the University of Copenhagen DISEASES database for IL6 (see all 36):
    Vascular disease     Multiple myeloma     Arthritis     Heart disease
    Diabetes mellitus     Chorioamnionitis     Kidney disease     Periodontal disease
    Brain disease     Connective tissue disease     Hypersensitivity reaction type II disease     Pancreatitis
    Pneumonia     Peritonitis     Lymphoma     Liver disease
    Kaposi's sarcoma     Respiratory failure     Inflammatory bowel disease     Skin disease

    IL6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/95 Novoseek inferred disease relationships for IL6 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 95.5 13028 9290459 (7), 15105666 (7), 8855783 (6), 17173645 (6) (see all 99)
    inflammation 91.5 2296 15935563 (5), 17374166 (5), 16518702 (5), 17130257 (4) (see all 99)
    tumors 88.6 12141 15185009 (8), 10375098 (7), 9290459 (7), 15105666 (7) (see all 99)
    response acute phase 88.5 588 10080883 (5), 7512810 (4), 1883959 (3), 17703320 (3) (see all 99)
    systemic inflammatory response syndrome 80 106 15641601 (3), 8379598 (3), 10521088 (2), 10966252 (2) (see all 69)
    myeloma 79.8 1104 10691869 (9), 1954351 (6), 15809207 (6), 15570293 (5) (see all 99)
    rheumatoid arthritis 79.5 588 7944637 (6), 16582692 (5), 9410434 (4), 18419107 (3) (see all 99)
    sepsis 76.9 740 16635168 (7), 8797615 (6), 11975924 (6), 11421413 (5) (see all 99)
    insulin resistance 72.3 423 19188739 (5), 12952969 (4), 18991689 (3), 17322479 (3) (see all 99)
    castleman disease 71.9 137 18784373 (4), 9462253 (3), 17075601 (2), 19270642 (2) (see all 86)

    Genetic Association Database (GAD): IL6
    Human Genome Epidemiology (HuGE) Navigator: IL6 (1228 documents)

    Export disorders for IL6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL6 gene, integrated from 9 sources (see all 12173):
    (articles sorted by number of sources associating them with IL6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density. (PubMed id 11355017)1, 2, 4, 9 Ota N.... Emi M. (2001)
    2. Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women. (PubMed id 12768442)1, 2, 4 Chung H.W.... Shin H.D. (2003)
    3. The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults. (PubMed id 11282548)1, 4, 9 Kilpinen S....Hurme M. (2001)
    4. Long term exercise training decreases IL-6 serum levels in subjects with impaired glucose tolerance: effect of the -174G/C variant in interleukin-6 gene. (PubMed id 18469018)1, 4, 9 Oberbach A....Kovacs P. (2008)
    5. Relationship between interleukin 6 promoter polymorphism at position -174, IL-6 serum levels, and the risk of relapse/recurrence in polymyalgia rheumatica. (PubMed id 16583473)1, 4, 9 Boiardi L....Salvarani C. (2006)
    6. IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study. (PubMed id 19272152)1, 4, 9 Yanbaeva D.G....Wouters E.F. (2009)
    7. [The study of the relationship between interleukin gene polymorphism and the morbidity of patients with acute pancreatitis.] (PubMed id 19220961)1, 4, 9 Chen X.Q....Chen Y.C. (2009)
    8. Association of interleukin (IL)-4 intron-3 and IL-6 -174 G/C gene polymorphism with susceptibility to end-stage renal disease. (PubMed id 17203290)1, 4, 9 Mittal R.D. and Manchanda P.K. (2007)
    9. Lack of association of interleukin-6 and interleukin-8 gene polymorphisms in Chinese patients with systemic lupus erythematosus. (PubMed id 17115422)1, 4, 9 Huang C.M....Tsai F.J. (2006)
    10. Polymorphisms of IL-6 174 G/C, IL-10 -592 C/A and ris k of HIV/AIDS among North Indian population. (PubMed id 19936625)1, 4, 9 Sobti R.C....Wanchu A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3569 HGNC: 6018 AceView: IL6 Ensembl:ENSG00000136244 euGenes: HUgn3569
    ECgene: IL6 Kegg: 3569 H-InvDB: IL6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL6 Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine mini-reviews: IL-6http://www.rndsystems.com/molecule_detail.aspx?m=1648
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_6
    SeattleSNPshttp://pga.gs.washington.edu/data/il6/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL6

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL6 gene:
    Search GeneIP for patents involving IL6

    Licensable Technologies for IL6 gene:
    Weizmann Institute:Enrichment of Repopulating Stem Cells For Clinical Protocols
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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