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Aliases for IL6 Gene

Aliases for IL6 Gene

  • Interleukin 6 2 3
  • IFNB2 3 4 6
  • B-Cell Stimulatory Factor 2 3 4
  • CTL Differentiation Factor 3 4
  • Hybridoma Growth Factor 3 4
  • Interferon Beta-2 3 4
  • IFN-Beta-2 3 4
  • BSF-2 3 4
  • BSF2 3 6
  • IL-6 3 4
  • HGF 3 6
  • HSF 3 6
  • CDF 3 4
  • Interleukin 6 (Interferon, Beta 2) 2
  • B-Cell Differentiation Factor 3
  • Interferon, Beta 2 3
  • Interleukin BSF-2 3
  • Interleukin-6 3
  • Interferon 2
  • Beta 2 2

External Ids for IL6 Gene

Previous Symbols for IL6 Gene

  • IFNB2

Summaries for IL6 Gene

Entrez Gene Summary for IL6 Gene

  • This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]

GeneCards Summary for IL6 Gene

IL6 (Interleukin 6) is a Protein Coding gene. Diseases associated with IL6 include acute cystitis and rheumatoid arthritis, systemic juvenile. Among its related pathways are PI3K-Akt signaling pathway and Glioma. GO annotations related to this gene include cytokine activity and interleukin-6 receptor binding.

UniProtKB/Swiss-Prot for IL6 Gene

  • Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation

Gene Wiki entry for IL6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL6 Gene

Genomics for IL6 Gene

Genomic Location for IL6 Gene

Start:
22,725,884 bp from pter
End:
22,732,002 bp from pter
Size:
6,119 bases
Orientation:
Plus strand

Genomic View for IL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL6 Gene

Regulatory Elements for IL6 Gene

Proteins for IL6 Gene

  • Protein details for IL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05231-IL6_HUMAN
    Recommended name:
    Interleukin-6
    Protein Accession:
    P05231
    Secondary Accessions:
    • Q9UCU2
    • Q9UCU3
    • Q9UCU4

    Protein attributes for IL6 Gene

    Size:
    212 amino acids
    Molecular mass:
    23718 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL6 Gene

neXtProt entry for IL6 Gene

Proteomics data for IL6 Gene at MOPED

Post-translational modifications for IL6 Gene

Other Protein References for IL6 Gene

No data available for DME Specific Peptides for IL6 Gene

Domains for IL6 Gene

Gene Families for IL6 Gene

HGNC:
  • IL :Interleukins and interleukin receptors
  • IFN :Interferons

UniProtKB/Swiss-Prot:

IL6_HUMAN
Family:
  • Belongs to the IL-6 superfamily.:
    • P05231
genes like me logo Genes that share domains with IL6: view

Function for IL6 Gene

Molecular function for IL6 Gene

GENATLAS Biochemistry: interleukin 6,23.7kDa,involved in the regulation of immune response,hematopoiesis,platelet production,acute phase reaction and bone resorption (susceptibility factor for osteopenia),playing a role in the aggressiveness of non hodgkin lymphoma by stimulating MMP2 and MMP9
UniProtKB/Swiss-Prot Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation

LifeMap Function Summary for IL6 Gene

During embryonic development, IL6 as signaling molecule is secreted from the following cells
It affects the following cells:
IL6 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for IL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005125 cytokine activity NAS 10443688
GO:0005138 interleukin-6 receptor binding NAS 1883960
GO:0005515 protein binding IPI 11238858
GO:0008083 growth factor activity IDA 12643274
genes like me logo Genes that share ontologies with IL6: view
genes like me logo Genes that share phenotypes with IL6: view

Animal Models for IL6 Gene

MGI Knock Outs for IL6:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL6 Gene

Localization for IL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL6 Gene COMPARTMENTS Subcellular localization image for IL6 gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
mitochondrion 2
peroxisome 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 10443688
GO:0005737 cytoplasm IEA --
GO:0005896 interleukin-6 receptor complex IDA 12829785
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with IL6: view

Pathways for IL6 Gene

genes like me logo Genes that share pathways with IL6: view

Gene Ontology (GO) - Biological Process for IL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001781 neutrophil apoptotic process IDA 7595060
GO:0002262 myeloid cell homeostasis --
GO:0002384 hepatic immune response TAS 12832423
GO:0002446 neutrophil mediated immunity TAS 16034137
GO:0002548 monocyte chemotaxis IC 10510402
genes like me logo Genes that share ontologies with IL6: view

Compounds for IL6 Gene

(1) HMDB Compounds for IL6 Gene

Compound Synonyms Cas Number PubMed IDs
Simvastatin
  • (+)-Simvastatin
79902-63-9

(1) Drugbank Compounds for IL6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Ginseng
50647-08-0 target antagonist

(136) Novoseek inferred chemical compound relationships for IL6 Gene

Compound -log(P) Hits PubMed IDs
gp 130 92 318
endotoxin 81.9 272
rantes 81.3 236
tocilizumab 78.8 81
il 10 78.4 165

(2) PharmGKB related drug/compound annotations for IL6 Gene

Drug/compound Annotation
fenofibrate CA
rituximab
genes like me logo Genes that share compounds with IL6: view

Transcripts for IL6 Gene

Unigene Clusters for IL6 Gene

Interleukin 6 (interferon, beta 2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL6 Gene

No ASD Table

Relevant External Links for IL6 Gene

GeneLoc Exon Structure for
IL6
ECgene alternative splicing isoforms for
IL6

Expression for IL6 Gene

mRNA expression in normal human tissues for IL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL6 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (10.0), Heart - Atrial Appendage (6.6), and Lung (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL6 Gene

SOURCE GeneReport for Unigene cluster for IL6 Gene Hs.654458

genes like me logo Genes that share expressions with IL6: view

Orthologs for IL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL6 36
  • 99.69 (n)
  • 99.53 (a)
IL6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL6 37
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL6 36
  • 76.81 (n)
  • 60.39 (a)
IL6 37
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il6 36
  • 61.24 (n)
  • 41.63 (a)
Il6 16
Il6 37
  • 41 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL6 37
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL6 37
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il6 36
  • 59.01 (n)
  • 39.71 (a)
chicken
(Gallus gallus)
Aves IL6 36
  • 53.43 (n)
  • 39.2 (a)
IL6 37
  • 30 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL6 37
  • 29 (a)
OneToOne
Species with no ortholog for IL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL6 Gene

ENSEMBL:
Gene Tree for IL6 (if available)
TreeFam:
Gene Tree for IL6 (if available)

Paralogs for IL6 Gene

No data available for Paralogs for IL6 Gene

Variants for IL6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IL6 Gene

P05231-IL6_HUMAN
Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture

Sequence variations from dbSNP and Humsavar for IL6 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1474347 -- 22,728,505(-) CACCT(G/T)TGACT intron-variant
rs1474348 -- 22,728,289(-) TCCAC(C/G)CCCAA intron-variant
rs1524107 -- 22,728,600(+) AGAGA(C/T)TTTCC intron-variant
rs1548216 -- 22,730,154(+) CCAAA(C/G)GCTTT intron-variant, utr-variant-3-prime
rs1554606 -- 22,729,088(+) TACTC(G/T)CAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL6 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
dgv2070e1 CNV Complex 17122850

Relevant External Links for IL6 Gene

HapMap Linkage Disequilibrium report
IL6
Human Gene Mutation Database (HGMD)
IL6

Disorders for IL6 Gene

(5) OMIM Diseases for IL6 Gene (147620)

UniProtKB/Swiss-Prot

IL6_HUMAN
  • Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.

(95) Novoseek inferred disease relationships for IL6 Gene

Disease -log(P) Hits PubMed IDs
necrosis 95.5 363
inflammation 91.5 239
tumors 88.6 421
response acute phase 88.5 161
systemic inflammatory response syndrome 80 77

Relevant External Links for IL6

Genetic Association Database (GAD)
IL6
Human Genome Epidemiology (HuGE) Navigator
IL6
genes like me logo Genes that share disorders with IL6: view

Publications for IL6 Gene

  1. A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density. (PMID: 11355017) Ota N. … Emi M. (J. Hum. Genet. 2001) 3 4 23 49
  2. Interleukin-6 promoter polymorphism (--174 G/C) in Caucasian German patients with systemic lupus erythematosus. (PMID: 11312376) Schotte H. … Gaubitz M. (Rheumatology (Oxford) 2001) 3 23 49
  3. High-resolution analysis of IL-6 minisatellite polymorphism in Sardinian multiple sclerosis: effect on course and onset of disease. (PMID: 11196678) Vandenbroeck K. … Opdenakker G. (Genes Immun. 2000) 3 23 49
  4. The polymorphism at position -174 of the IL-6 gene is not associated with inflammatory bowel disease. (PMID: 11204808) Klein W. … Epplen J.T. (Eur J Gastroenterol Hepatol 2001) 3 23 49
  5. The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults. (PMID: 11282548) Kilpinen S. … Hurme M. (Eur. Cytokine Netw. 2001) 3 23 49

Products for IL6 Gene

Sources for IL6 Gene

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