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IL6 Gene

protein-coding   GIFtS: 71
GCID: GC07P022765

Interleukin 6 (Interferon, Beta 2)


(Previous symbol: IFNB2)
  See IL6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 6 (Interferon, Beta 2)1 2     B-Cell Stimulatory Factor 22 3
IFNB21 2 3 5     CTL Differentiation Factor2 3
Hybridoma Growth Factor2 3     BSF22 5
Interferon Beta-22 3     HGF2 5
BSF-22 3     HSF2 5
CDF2 3     B-Cell Differentiation Factor2
IFN-beta-22 3     Interleukin BSF-22
IL-62 3     interleukin-62

External Ids:    HGNC: 60181   Entrez Gene: 35692   Ensembl: ENSG000001362447   OMIM: 1476205   UniProtKB: P052313   

Export aliases for IL6 gene to outside databases

Previous GC identifers: GC07P022409 GC07P022509 GC07P022540 GC07P022732


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL6 Gene:
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the
encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune
diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is
secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor,
alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states,
including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. (provided by RefSeq,
Jun 2011)

GeneCards Summary for IL6 Gene:
IL6 (interleukin 6 (interferon, beta 2)) is a protein-coding gene. Diseases associated with IL6 include diabetes mellitus, and castleman's disease. GO annotations related to this gene include interleukin-6 receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IL6_HUMAN, P05231
Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase
response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in
lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells
differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also
acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the
breakdown of fats and to improve insulin resistance

summary for IL6 Gene:
MET (Mesenchymal epithelial transition factor), also known as hepatocyte growth factor receptor (HGFR) is a
proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter
factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the
adult, MET expression is limited to stem and progenitor cells and is necessary for wound healing and
hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are
essential for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abberant activation of
the HGF/MET pathway leads to a variety of cancers. MET mutation is associated with a poor prognosis as it
can trigger tumor growth, angiogenesis and metastasis.

Gene Wiki entry for IL6 (Interleukin 6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL6 gene promoter:
         GR   C/EBPbeta   Nkx2-2   GR-beta   YY1   IRF-2   FOXJ2 (long isoform)   STAT3   FOXJ2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL6 promoter sequence
   Search Chromatin IP Primers for IL6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p21-p15

IL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P022765:  view genomic region     (about GC identifiers)

Start:
22,765,503 bp from pter      End:
22,771,621 bp from pter
Size:
6,119 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 22,817,875-22,822,730     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IL6_HUMAN, P05231 (See protein sequence)
Recommended Name: Interleukin-6 precursor  
Size: 212 amino acids; 23718 Da
Selected PDB 3D structures from and Proteopedia for IL6 (see all 7):
1ALU (3D)        1IL6 (3D)        1N2Q (3D)        1P9M (3D)        2IL6 (3D)        4NI7 (3D)    
Secondary accessions: Q9UCU2 Q9UCU3 Q9UCU4

Explore the universe of human proteins at neXtProt for IL6: NX_P05231

Explore proteomics data for IL6 at MOPED

Post-translational modifications: 

  • N- and O-glycosylated1
  • Glycosylation2 at Asn73

  • See IL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000591.1  
    ENSEMBL proteins: 
     ENSP00000385675   ENSP00000405150   ENSP00000385718   ENSP00000385043   ENSP00000384928  
     ENSP00000385227   ENSP00000258743   ENSP00000405994  
    Reactome Protein details: P05231

    IL6 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IL6 Protein
    R&D Systems Recombinant & Natural Proteins for IL6 (IL-6)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IL6
    OriGene Protein Over-expression Lysate for IL6
    OriGene MassSpec for IL6
    OriGene Custom Protein Services for IL6
    GenScript Purified and Recombinant Proteins for IL6
    Novus Biologicals IL6 Proteins
    Novus Biologicals IL6 Lysates
    Sino Biological Recombinant Protein for IL6
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IL6
    Cloud-Clone Corp. Proteins for IL6

     
    eBioscience Proteins for IL6: (see all 4
                        Recombinant Human IL-6 20 ug

     
    antibodies-online proteins for IL6 (218 products) 

     
    antibodies-online peptides for IL6

    IL6 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL6
    R&D Systems Antibodies for IL6 (IL-6)
    OriGene Antibodies for IL6
    OriGene Custom Antibody Services for IL6
    Novus Biologicals IL6 Antibodies
    Abcam antibodies for IL6
    Cloud-Clone Corp. Antibodies for IL6
    ThermoFisher Antibody for IL6
    antibodies-online antibodies for IL6 

    IL6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL6
    R&D Systems Flow Cytometry Kits for IL6 (IL-6)         (see all)
    GenScript Custom Assay Services for IL6
    Enzo Life Sciences assays for IL6
    Cloud-Clone Corp. ELISAs for IL6
    Cloud-Clone Corp. CLIAs for IL6
    eBioscience ELISAs for IL6: (see all 8
                        Human IL-6 High Sensitivity ELISA 96 tests
    antibodies-online kits for IL6 (176 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFN: Interferons
    IL: Interleukins and interleukin receptors

    4 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core
     IPR003574 IL-6
     IPR003573 IL-6/IL-23/GCSF/MGF

    Graphical View of Domain Structure for InterPro Entry P05231

    ProtoNet protein and cluster: P05231

    1 Blocks protein domain: IPB003574 Interleukin-6 signature

    UniProtKB/Swiss-Prot: IL6_HUMAN, P05231
    Similarity: Belongs to the IL-6 superfamily


    Find genes that share domains with IL6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL6_HUMAN, P05231
    Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase
    response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in
    lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells
    differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also
    acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the
    breakdown of fats and to improve insulin resistance

         Genatlas biochemistry entry for IL6:
    interleukin 6,23.7kDa,involved in the regulation of immune response,hematopoiesis,platelet production,acute phase
    reaction and bone resorption (susceptibility factor for osteopenia),playing a role in the aggressiveness of non
    hodgkin lymphoma by stimulating MMP2 and MMP9

         Summary: 
    During embryonic development, IL6 as signaling molecule is secreted from the following cells:
                
    Adipose: Visceral White Adipocytes (Visceral White Adipose)
    Liver: Sinusoidal Endothelial Cells (Sinusoids)

    It affects the following cells:
    Liver: Hepatocytes (Liver Lobule)

    IL6 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 3)      fully expand
    Blood: Megakaryocytes-like cells, Hematopoietic progenitor cells      fully expand to see all 5 cells
    Adipose: Brown adipocyte-like cells, Spheres      fully expand to see all 2 cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005125cytokine activity NAS10443688
    GO:0005138interleukin-6 receptor binding NAS1883960
    GO:0005515protein binding IPI11238858
    GO:0008083growth factor activity IDA12643274
         
    Find genes that share ontologies with IL6           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il6) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  muscle  nervous system 

    Find genes that share phenotypes with IL6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL6: Il6tm1Poli Il6tm1Mur Il6tm1Kopf

       genOway: Develop your customized and physiologically relevant rodent model for IL6

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL6:
    hsa-mir-124-3p (MIRT022183), hsa-mir-1 (MIRT023501), hsa-mir-155-5p (MIRT021049), hsa-mir-365a-3p (MIRT020073), hsa-mir-26a-5p (MIRT007374), hsa-mir-98-5p (MIRT027449), hsa-mir-335-5p (MIRT016949), hsa-let-7a-5p (MIRT005420)

    Block miRNA regulation of human, mouse, rat IL6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL6 (see all 14):
    hsa-miR-98 hsa-miR-676 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-548o hsa-let-7i hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidIL6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL6
    Predesigned siRNA for gene silencing in human, mouse, rat IL6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL6

    Clone
    Products:
         
    OriGene clones in human, mouse for IL6 (see all 7)
    OriGene ORF clones in mouse, rat for IL6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL6 (NM_000600)
    Sino Biological Human cDNA Clone for IL6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL6
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-13526 VA6-12712 VF1-12797) for IL6 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL6_HUMAN, P05231: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    nucleus3
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    mitochondrion2
    peroxisome2
    lysosome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA10443688
    GO:0005896interleukin-6 receptor complex IDA12829785
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with IL6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL6 About   (see all 81)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    2PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    Regulation of toll-like receptor signaling pathway0.93
    4Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    Bacterial infections in CF airways0.78
    5Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61


    Find genes that share SuperPaths with IL6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for IL6 (see all 6)
        NOD-like Receptor Signaling Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Adipocytokines & Insulin Signaling
    IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL6 (see all 74)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for IL6 (see all 14)
        Immune response IL-6 signaling pathway
    Immune response MIF-mediated glucocorticoid regulation
    Transcription Androgen Receptor nuclear signaling
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response

    Selected BioSystems Pathways for IL6 (see all 21)
        Myometrial Relaxation and Contraction Pathways
    Cytokines and Inflammatory Response
    Senescence and Autophagy
    Adipogenesis
    SIDS Susceptibility Pathways


    2 Reactome Pathways for IL6
        Senescence-Associated Secretory Phenotype (SASP)
    Interleukin-6 signaling


    Selected Kegg Pathways  (Kegg details for IL6) (see all 32):
        Cytokine-cytokine receptor interaction
    HIF-1 signaling pathway
    FoxO signaling pathway
    PI3K-Akt signaling pathway
    Toll-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL6 (see all 45): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              Lymphoma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL6 (P052311, 2, 3 ENSP000002587434) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL6RP088871, 3, ENSP000003574704EBI-720533,EBI-299383 I2D: score=5 STRING: ENSP00000357470
    SH3GL2Q999622, 3, ENSP000003699814MINT-63404 I2D: score=6 STRING: ENSP00000369981
    ZBTB16Q055162, 3, ENSP000003381574MINT-63403 I2D: score=4 STRING: ENSP00000338157
    IL6STP401893, ENSP000003387994I2D: score=5 STRING: ENSP00000338799
    PCBP1Q153653, ENSP000003055564I2D: score=1 STRING: ENSP00000305556
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 98):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001781neutrophil apoptotic process IDA7595060
    GO:0002384hepatic immune response TAS12832423
    GO:0002446neutrophil mediated immunity IC16034137
    GO:0002548monocyte chemotaxis IC10510402
    GO:0002675positive regulation of acute inflammatory response IDA2444978

    Find genes that share ontologies with IL6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for IL6
      Browse compounds at ApexBio 

    Compounds for IL6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CrizotinibPotent c-MET/ALK inhibitor[877399-52-5]
    PF 04217903 mesylateHighly selective c-Met inhibitor[956906-93-7]
    PHA 665752Potent and selective MET inhibitor[477575-56-7]
    SU 11274Selective inhibitor of MET kinase activity[658084-23-2]

    1 HMDB Compound for IL6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    1 DrugBank Compound for IL6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ginseng-- 50647-08-0targetantagonist14642426 17436372

    Selected Novoseek inferred chemical compound relationships for IL6 gene (see all 136)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 92 1249 7812050 (6), 9126968 (5), 1602143 (5), 8467812 (5) (see all 99)
    endotoxin 81.9 867 8243265 (7), 19669960 (7), 11990931 (6), 10499730 (6) (see all 99)
    rantes 81.3 612 16413378 (6), 16466762 (6), 19932032 (6), 12509950 (6) (see all 99)
    tocilizumab 78.8 109 18784373 (7), 16102523 (4), 17214583 (3), 18664393 (3) (see all 58)
    il 10 78.4 260 19084425 (6), 12394188 (5), 12719394 (5), 19199277 (4) (see all 99)
    pge2 76.3 1475 9556135 (9), 8520508 (8), 16145911 (6), 9160463 (6) (see all 99)
    vegf 74.3 1899 15840215 (11), 11753617 (10), 12147798 (9), 13129863 (9) (see all 99)
    neopterin 73.6 312 1933885 (6), 9243197 (6), 10211419 (5), 8844226 (4) (see all 99)
    fibrinogen 73.3 1127 16703188 (8), 10959691 (6), 16159604 (5), 20059469 (5) (see all 99)
    dexamethasone 67.9 779 9207463 (8), 11713366 (6), 8550757 (6), 10880513 (5) (see all 99)

    2 PharmGKB related drug/compound annotations for IL6 gene    About this table
    Drug/compound PharmGKB Annotation
    fenofibrateCA  
    rituximab



    Find genes that share compounds with IL6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL6 gene: 
    NM_000600.3  

    Unigene Cluster for IL6:

    Interleukin 6 (interferon, beta 2)
    Hs.654458  [show with all ESTs]
    Unigene Representative Sequence: BM906445
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404625 ENST00000426291 ENST00000401651 ENST00000485300 ENST00000407492
    ENST00000401630 ENST00000406575 ENST00000464710 ENST00000258743(uc003svj.4)
    ENST00000420258(uc011jyo.1 uc011jyp.1 uc011jyq.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IL6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL6 (see all 14):
    hsa-miR-98 hsa-miR-676 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-548o hsa-let-7i hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidIL6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IL6
    Predesigned siRNA for gene silencing in human, mouse, rat IL6
    Clone
    Products:
         
    OriGene clones in human, mouse for IL6 (see all 7)
    OriGene ORF clones in mouse, rat for IL6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL6 (NM_000600)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL6
    Primer
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    OriGene qPCR primer pairs and template standards for IL6
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13526 VA6-12712 VF1-12797) for IL6 

    Additional mRNA sequence: 

    AK298013.1 AK298077.1 AK301141.1 BC015511.1 BT019748.1 BT019749.1 CR450296.1 M14584.1 
    M18403.1 M29150.1 M54894.1 S56892.1 X04403.1 X04430.1 X04602.1 

    7 DOTS entries:

    DT.212868  DT.91771152  DT.40189406  DT.85101821  DT.121119373  DT.40128177  DT.95261924 

    Selected AceView cDNA sequences (see all 141):

    AW966001 BM955891 CD367420 BQ102313 CD366448 CR626263 AL544153 AI751501 
    X04602 BU626816 C21585 AA381892 AA362308 AA381568 BX097268 M18403 
    AU098441 BU626761 CA444433 AW134706 BQ008421 CD370272 CA431676 BM694818 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCACCTCAG
    IL6 Expression
    About this image


    IL6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 10 entries
             Endochondral Osteoblasts Autopod Periosteum
             Bone Marrow
             GLP-transfected mesenchymal stem cells
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Mesenchymal Stem Cells Wharton's Jelly
             Umbilical tissue-derived cells (CNTO2476)
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Wharton's Jelly
             Placenta-derived mesenchymal stem cells (family)
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Inner Cell Mass (Early Embryo)    fully expand to see all 3 entries
             Zygote Zygote
             Line H9 (Naive)
    IL6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654458
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL6 (see all 45): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              Lymphoma in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL6 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il61 , 5 interleukin 61, 5 61.24(n)1
    41.63(a)1
      5 (15.70 cM)5
    161931  NM_031168.11  NP_112445.11 
     300131615 
    chicken
    (Gallus gallus)
    Aves IL61 interleukin 6 (interferon, beta 2) 53.43(n)
    39.2(a)
      395337  NM_204628.1  NP_989959.1 
    lizard
    (Anolis carolinensis)
    Reptilia IL66
    interleukin 6 (interferon, beta 2)
    29(a)
    1 ↔ 1
    6(30304240-30310770)


    ENSEMBL Gene Tree for IL6 (if available)
    TreeFam Gene Tree for IL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    IL6_HUMAN, P05231: Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk
    factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of
    bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone.
    Osteoporotic bones are more at risk of fracture


    Selected SNPs for IL6 (see all 107)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828128601,2
    C--22743305(+) ATCCAC/GTTCCT 2 H Q mis10--------
    rs2010240111,2
    --22743338(+) TCATTC/TCCTCA 1 -- int10--------
    rs2007172931,2
    --22743342(+) TCCCTC/TAACTT 1 -- int10--------
    rs20698421,2
    C,F,A,H--22743351(+) TTGGTG/ATGGGG 1 -- int127Minor allele frequency- A:0.04NS MN EA NA WA CSA 3352
    rs1438081441,2
    --22743405(+) AATGCC/TACTTC 1 -- int10--------
    rs1166939671,2
    F--22743428(+) CTACAC/TGTAAA 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1472392501,2
    --22743558(+) GAGGTA/GGATTT 1 -- int10--------
    rs1995006901,2
    --22743606(+) AAGGC-/GGGGGG 1 -- int10--------
    rs1856813771,2
    --22743616(+) GGGCGA/GGCAGA 1 -- int10--------
    rs1125388181,2
    C--22743805(+) AAAGAC/GGTACC 1 -- int12Minor allele frequency- G:0.33CSA 3

    HapMap Linkage Disequilibrium report for IL6 (22765503 - 22771621 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL6:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2070e1CNV Complex17122850
    nsv7393OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): IL6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL6
    DNA2.0 Custom Variant and Variant Library Synthesis for IL6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147620   
    OMIM disorders: 604302  148000  125853  108010  266600  
    UniProtKB/Swiss-Prot: IL6_HUMAN, P05231
  • Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with
    systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with
    severe extraarticular features and occasionally fatal complications. During active phases of the disorder,
    patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly,
    serositis, myalgia and arthritis. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry
  • Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in
    HIV-infected men

  • Selected diseases for IL6 (see all 99):    
    About MalaCards
    diabetes mellitus    castleman's disease    crohn disease-associated growth failure    acute cystitis
    polyclonal hypergammaglobulinemia    plasmacytoma    kaposi's sarcoma    cervical incompetence
    cyclic vomiting syndrome    vibrio vulnificus infection    intracranial hemorrhage in brain cerebrovascular malformations    crohn's disease
    juvenile rheumatoid arthritis    poems syndrome    ornithosis    spermatocele
    complex regional pain syndrome type 1    cyclic thrombocytopenia    complex regional pain syndrome    glossitis

    Selected diseases from the University of Copenhagen DISEASES database for IL6 (see all 36):
    Vascular disease     Multiple myeloma     Arthritis     Heart disease
    Diabetes mellitus     Chorioamnionitis     Kidney disease     Periodontal disease
    Brain disease     Connective tissue disease     Hypersensitivity reaction type II disease     Pancreatitis
    Pneumonia     Peritonitis     Lymphoma     Liver disease
    Kaposi's sarcoma     Respiratory failure     Inflammatory bowel disease     Skin disease

    Find genes that share disorders with IL6           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL6 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 95.5 13028 9290459 (7), 15105666 (7), 8855783 (6), 17173645 (6) (see all 99)
    inflammation 91.5 2296 15935563 (5), 17374166 (5), 16518702 (5), 17130257 (4) (see all 99)
    tumors 88.6 12141 15185009 (8), 10375098 (7), 9290459 (7), 15105666 (7) (see all 99)
    response acute phase 88.5 588 10080883 (5), 7512810 (4), 1883959 (3), 17703320 (3) (see all 99)
    systemic inflammatory response syndrome 80 106 15641601 (3), 8379598 (3), 10521088 (2), 10966252 (2) (see all 69)
    myeloma 79.8 1104 10691869 (9), 1954351 (6), 15809207 (6), 15570293 (5) (see all 99)
    rheumatoid arthritis 79.5 588 7944637 (6), 16582692 (5), 9410434 (4), 18419107 (3) (see all 99)
    sepsis 76.9 740 16635168 (7), 8797615 (6), 11975924 (6), 11421413 (5) (see all 99)
    insulin resistance 72.3 423 19188739 (5), 12952969 (4), 18991689 (3), 17322479 (3) (see all 99)
    castleman disease 71.9 137 18784373 (4), 9462253 (3), 17075601 (2), 19270642 (2) (see all 86)

    Genetic Association Database (GAD): IL6
    Human Genome Epidemiology (HuGE) Navigator: IL6 (1228 documents)

    Export disorders for IL6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL6 gene, integrated from 10 sources (see all 12296):
    (articles sorted by number of sources associating them with IL6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density. (PubMed id 11355017)1, 2, 4, 9 Ota N.... Emi M. (J. Hum. Genet. 2001)
    2. Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women. (PubMed id 12768442)1, 2, 4 Chung H.W.... Shin H.D. (J. Hum. Genet. 2003)
    3. The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults. (PubMed id 11282548)1, 4, 9 Kilpinen S....Hurme M. (Eur. Cytokine Netw. 2001)
    4. Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the -174G/C variant in IL-6 gene. (PubMed id 18469018)1, 4, 9 Oberbach A....Kovacs P. (Eur. J. Endocrinol. 2008)
    5. Relationship between interleukin 6 promoter polymorphism at position -174, IL-6 serum levels, and the risk of relapse/recurrence in polymyalgia rheumatica. (PubMed id 16583473)1, 4, 9 Boiardi L....Salvarani C. (J. Rheumatol. 2006)
    6. IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study. (PubMed id 19272152)1, 4, 9 Yanbaeva D.G....Wouters E.F. (BMC Med. Genet. 2009)
    7. [The study of the relationship between interleukin gene polymorphism and the morbidity of patients with acute pancreatitis]. (PubMed id 19220961)1, 4, 9 Chen X.Q....Chen Y.C. (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2009)
    8. Association of interleukin (IL)-4 intron-3 and IL-6 -174 G/C gene polymorphism with susceptibility to end-stage renal disease. (PubMed id 17203290)1, 4, 9 Mittal R.D. and Manchanda P.K. (Immunogenetics 2007)
    9. Lack of association of interleukin-6 and interleukin-8 gene polymorphisms in Chinese patients with systemic lupus erythematosus. (PubMed id 17115422)1, 4, 9 Huang C.M....Tsai F.J. (J. Clin. Lab. Anal. 2006)
    10. Polymorphisms of IL-6 174 G/C, IL-10 -592 C/A and risk of HIV/AIDS among North Indian population. (PubMed id 19936625)1, 4, 9 Sobti R.C....Wanchu A. (Mol. Cell. Biochem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3569 HGNC: 6018 AceView: IL6 Ensembl:ENSG00000136244 euGenes: HUgn3569
    ECgene: IL6 Kegg: 3569 H-InvDB: IL6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IL6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL6 Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine mini-reviews: IL-6http://www.rndsystems.com/molecule_detail.aspx?m=1648
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_6
    SeattleSNPshttp://pga.gs.washington.edu/data/il6/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL6

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL6 gene:
    Search GeneIP for patents involving IL6

    Licensable Technologies for IL6 gene:
    Weizmann Institute:Enrichment of Repopulating Stem Cells For Clinical Protocols
    GeneCards and IP:
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