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Aliases for IL5RA Gene

Aliases for IL5RA Gene

  • Interleukin 5 Receptor Subunit Alpha 2 3 5
  • Interleukin 5 Receptor, Alpha 2 3
  • IL-5 Receptor Subunit Alpha 3 4
  • IL-5R Subunit Alpha 3 4
  • CD125 Antigen 3 4
  • CDw125 3 4
  • IL5R 3 4
  • Interleukin-5 Receptor Alpha Chain 3
  • Interleukin 5 Receptor Type 3 3
  • IL-5R-Alpha 4
  • HSIL5R3 3
  • IL-5RA 4
  • CD125 3

External Ids for IL5RA Gene

Previous HGNC Symbols for IL5RA Gene

  • IL5R

Previous GeneCards Identifiers for IL5RA Gene

  • GC03M003040
  • GC03M003086
  • GC03M003045

Summaries for IL5RA Gene

Entrez Gene Summary for IL5RA Gene

  • The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]

GeneCards Summary for IL5RA Gene

IL5RA (Interleukin 5 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL5RA include Eosinophilia and Asthma. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and G beta-gamma signalling through PI3Kgamma. GO annotations related to this gene include cytokine receptor activity and interleukin-5 receptor activity. An important paralog of this gene is IL13RA1.

UniProtKB/Swiss-Prot for IL5RA Gene

  • This is the receptor for interleukin-5. The alpha chain binds to IL5.

Tocris Summary for IL5RA Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL5RA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL5RA Gene

Genomics for IL5RA Gene

Regulatory Elements for IL5RA Gene

Enhancers for IL5RA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL5RA on UCSC Golden Path with GeneCards custom track

Genomic Location for IL5RA Gene

Chromosome:
3
Start:
3,066,324 bp from pter
End:
3,126,613 bp from pter
Size:
60,290 bases
Orientation:
Minus strand

Genomic View for IL5RA Gene

Genes around IL5RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL5RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL5RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL5RA Gene

Proteins for IL5RA Gene

  • Protein details for IL5RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01344-IL5RA_HUMAN
    Recommended name:
    Interleukin-5 receptor subunit alpha
    Protein Accession:
    Q01344
    Secondary Accessions:
    • B3IU77
    • B4E2G0
    • Q14633
    • Q15469
    • Q6ISX9

    Protein attributes for IL5RA Gene

    Size:
    420 amino acids
    Molecular mass:
    47685 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Interacts with SDCBP.

    Three dimensional structures from OCA and Proteopedia for IL5RA Gene

    Alternative splice isoforms for IL5RA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL5RA Gene

Proteomics data for IL5RA Gene at MOPED

Post-translational modifications for IL5RA Gene

  • Glycosylation at Asn 35, Asn 131, Asn 216, and Asn 244
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for IL5RA (IL-5 R alpha/CD125)

No data available for DME Specific Peptides for IL5RA Gene

Domains & Families for IL5RA Gene

Graphical View of Domain Structure for InterPro Entry

Q01344

UniProtKB/Swiss-Prot:

IL5RA_HUMAN :
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
  • Contains 2 fibronectin type-III domains.
Family:
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
genes like me logo Genes that share domains with IL5RA: view

Function for IL5RA Gene

Molecular function for IL5RA Gene

GENATLAS Biochemistry:
interleukin 5,receptor,alpha subunit,with a membrane anchored and an alternatively spliced secreted form heterodimerizing with CSF2RB
UniProtKB/Swiss-Prot Function:
This is the receptor for interleukin-5. The alpha chain binds to IL5.

Gene Ontology (GO) - Molecular Function for IL5RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
genes like me logo Genes that share ontologies with IL5RA: view
genes like me logo Genes that share phenotypes with IL5RA: view

Animal Models for IL5RA Gene

MGI Knock Outs for IL5RA:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL5RA Gene

Localization for IL5RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL5RA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL5RA Gene COMPARTMENTS Subcellular localization image for IL5RA gene
Compartment Confidence
plasma membrane 5
extracellular 4

Gene Ontology (GO) - Cellular Components for IL5RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL5RA: view

Pathways & Interactions for IL5RA Gene

SuperPathways for IL5RA Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Akt Signaling
3 G beta-gamma signalling through PI3Kgamma
4 Signaling by GPCR
5 PEDF Induced Signaling
genes like me logo Genes that share pathways with IL5RA: view

SIGNOR curated interactions for IL5RA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL5RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0002437 inflammatory response to antigenic stimulus IEA --
GO:0007165 signal transduction TAS 1732409
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with IL5RA: view

Drugs & Compounds for IL5RA Gene

(8) Drugs for IL5RA Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
IL-5 Pharma Agonist 0
BENRALIZUMAB Pharma 0

(9) Additional Compounds for IL5RA Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AF 12198
185413-30-3
Lyn peptide inhibitor
222018-18-0
R 7050
303997-35-5
Ro 26-4550 trifluoroacetate
1217448-66-2
YM 90709
163769-88-8

(5) Tocris Compounds for IL5RA Gene

Compound Action Cas Number
AF 12198 Potent, selective human type I IL-1 receptor antagonist 185413-30-3
Lyn peptide inhibitor Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable 222018-18-0
R 7050 Inhibitor of TNF-alpha receptor 1 signaling 303997-35-5
Ro 26-4550 trifluoroacetate Competitive inhibitor of IL-2/ IL-2Ralpha receptor interaction 1217448-66-2
YM 90709 Interleukin-5 receptor antagonist 163769-88-8
genes like me logo Genes that share compounds with IL5RA: view

Transcripts for IL5RA Gene

Unigene Clusters for IL5RA Gene

Interleukin 5 receptor, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL5RA Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - - -
SP8: - - - -
SP9:

Relevant External Links for IL5RA Gene

GeneLoc Exon Structure for
IL5RA
ECgene alternative splicing isoforms for
IL5RA

Expression for IL5RA Gene

mRNA expression in normal human tissues for IL5RA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL5RA Gene

This gene is overexpressed in Whole Blood (x5.0) and Pituitary (x4.1).

Protein differential expression in normal tissues from HIPED for IL5RA Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL5RA Gene



SOURCE GeneReport for Unigene cluster for IL5RA Gene Hs.68876

mRNA Expression by UniProt/SwissProt for IL5RA Gene

Q01344-IL5RA_HUMAN
Tissue specificity: Expressed on eosinophils and basophils.
genes like me logo Genes that share expression patterns with IL5RA: view

Protein tissue co-expression partners for IL5RA Gene

Primer Products

Orthologs for IL5RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL5RA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL5RA 35
  • 81.98 (n)
  • 74.88 (a)
IL5RA 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL5RA 35
  • 80.9 (n)
  • 76.02 (a)
IL5RA 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il5ra 35
  • 76.94 (n)
  • 69.17 (a)
Il5ra 16
Il5ra 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL5RA 35
  • 98.89 (n)
  • 98.33 (a)
IL5RA 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il5ra 35
  • 76.72 (n)
  • 67.88 (a)
oppossum
(Monodelphis domestica)
Mammalia IL5RA 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL5RA 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL5RA 35
  • 55.96 (n)
  • 44.04 (a)
IL5RA 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il5ra 35
  • 46.36 (n)
  • 34.43 (a)
Species with no ortholog for IL5RA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL5RA Gene

ENSEMBL:
Gene Tree for IL5RA (if available)
TreeFam:
Gene Tree for IL5RA (if available)

Paralogs for IL5RA Gene

Paralogs for IL5RA Gene

(2) SIMAP similar genes for IL5RA Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IL5RA: view

Variants for IL5RA Gene

Sequence variations from dbSNP and Humsavar for IL5RA Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2290610 - 3,098,273(-) CCTCA(A/G)TTGTG reference, missense
rs17879690 - 3,095,369(-) ACCAG(C/T)GTCTG intron-variant, reference, missense
rs334782 -- 3,106,774(-) ATATT(A/G)TTTCA intron-variant
rs334783 -- 3,106,997(-) AAATA(G/T)TCAAT intron-variant
rs334784 -- 3,107,398(-) TGTTG(C/T)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL5RA Gene

Variant ID Type Subtype PubMed ID
esv2422274 CNV Duplication 17116639
esv2751994 CNV Gain 17911159
nsv521796 CNV Loss 19592680
nsv819643 CNV Loss 19587683
nsv518298 CNV Gain 19592680
nsv876405 CNV Gain 21882294

Variation tolerance for IL5RA Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL5RA Gene

Human Gene Mutation Database (HGMD)
IL5RA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL5RA Gene

Disorders for IL5RA Gene

MalaCards: The human disease database

(2) MalaCards diseases for IL5RA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
eosinophilia
  • eosinophil count raised
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards
Search IL5RA in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL5RA

Genetic Association Database (GAD)
IL5RA
Human Genome Epidemiology (HuGE) Navigator
IL5RA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL5RA
genes like me logo Genes that share disorders with IL5RA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL5RA Gene

Publications for IL5RA Gene

  1. Molecular cloning and expression of the human interleukin 5 receptor. (PMID: 1732409) Murata Y. … Takatsu K. (J. Exp. Med. 1992) 2 3 4 23 67
  2. Differential expression of the interleukin 5 receptor alpha isoforms in blood and tissue eosinophils of nasal polyp patients. (PMID: 19170670) Gevaert P. … Bachert C. (Allergy 2009) 3 23
  3. Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output. (PMID: 19654410) Beekman J.M. … Coffer P.J. (Blood 2009) 3 23
  4. Interleukin-5 receptor subunit oligomerization and rearrangement revealed by fluorescence resonance energy transfer imaging. (PMID: 18326494) Zaks-Zilberman M. … Chaiken I.M. (J. Biol. Chem. 2008) 3 23
  5. JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization. (PMID: 17227823) Martinez-Moczygemba M. … Lei J.T. (J. Leukoc. Biol. 2007) 3 23

Products for IL5RA Gene

Sources for IL5RA Gene

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