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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL5RA Gene

protein-coding GIFtS: 64
GCID: GC03M003111

interleukin 5 receptor, alpha

(Previous symbol: IL5R)

Explore 34 diseases affiliated with
IL5RA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 5 Receptor, Alpha¹ ²		HSIL5R3²
CDw125¹ ² ³		Interleukin 5 Receptor Type 3²
IL5R¹ ² ³		Interleukin-5 Receptor Alpha Chain²
CD125¹ ²		Interleukin-5 Receptor Subunit Alpha²
CD125 Antigen² ³		IL-5R-Alpha¹
IL-5 Receptor Subunit Alpha² ³		IL-5RA³
IL-5R Subunit Alpha² ³

External Ids:	HGNC: 6017¹	Entrez Gene: 3568²	Ensembl: ENSG00000091181⁷	OMIM: 147851⁵	UniProtKB: Q01344³

Export aliases for IL5RA gene to outside databases

Previous GC identifers: GC03M003040 GC03M003086 GC03M003045

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL5RA:

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The

receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors

for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this

protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for

the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin),

which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced

transcript variants encoding four distinct isoforms have been reported. (provided by RefSeq, Jul 2011)

UniProtKB/Swiss-Prot: IL5RA_HUMAN, Q01344

Function: This is the receptor for interleukin-5. The alpha chain binds to IL5

summary for IL5RA:

Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They

control many different cellular functions including proliferation, differentiation and cell

survival/apoptosis but are also involved in several pathophysiological processes including viral infections

and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the

innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can

be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,

IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.

Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL5RA (Interleukin 5 receptor alpha subunit)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL5RA gene promoter:
AML1a CUTL1 RelA Meis-1b FOXL1 AREB6 FOXO4 Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL5RA promoter sequence

Search SABiosciences Chromatin IP Primers for IL5RA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL5RA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p26-p24 Ensembl cytogenetic band: 3p26.2 HGNC cytogenetic band: 3p26-p24

IL5RA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL5RA gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M003111: view genomic region (about GC identifiers)

Start:	3,111,233 bp from pter	End:	3,168,297 bp from pter
Size:	57,065 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL5RA_HUMAN, Q01344 (See protein sequence)

Recommended Name: Interleukin-5 receptor subunit alpha precursor

Size: 420 amino acids; 47685 Da

Subunit: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.

Interacts with SDCBP

Subcellular location: Membrane; Single-pass type I membrane protein

4 PDB 3D structures from and Proteopedia for IL5RA:

1OBX (3D)

1OBZ (3D)

3QT2 (3D)

3VA2 (3D)

Secondary accessions: Q14633 Q15469 Q6ISX9

Alternative splicing: 3 isoforms: Q01344-1 Q01344-2 Q01344-3

Explore the universe of human proteins at neXtProt for IL5RA: NX_Q01344

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q01344

IL5RA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_000555.2 NP_001230028.1 NP_783851.1 NP_783852.1 NP_783853.1 NP_783854.1 NP_783855.1

ENSEMBL proteins:

ENSP00000412209 ENSP00000390753 ENSP00000256452 ENSP00000373358 ENSP00000309196

ENSP00000400400 ENSP00000392059 ENSP00000398117 ENSP00000391274 ENSP00000388858

ENSP00000402598

Reactome Protein details: Q01344
Human Recombinant Protein Products for IL5RA:

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	Novus Biologicals IL5RA Proteins Novus Biologicals IL5RA Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	TAS	1495999
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--

IL5RA for ontologies About GeneDecksing

IL5RA Antibody Products:

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	Browse Antibodies at Uscn
	ThermoFisher Antibody for IL5RA

Assay Products for IL5RA:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IL5RA
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL5RA for domains About GeneDecksing

4 InterPro domains/families:

IPR015321 IL6_recept-bd

IPR003961 Fibronectin_type3

IPR013783 Ig-like_fold

IPR003532 Short_hematopoietin_rcpt_2_CS

Graphical View of Domain Structure for InterPro Entry Q01344

ProtoNet protein and cluster: Q01344

1 Blocks protein family: IPB003532 Short hematopoietin receptor

UniProtKB/Swiss-Prot: IL5RA_HUMAN, Q01344

Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular

transport and cell-surface receptor binding

Domain: The box 1 motif is required for JAK interaction and/or activation

Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IL5RA_HUMAN, Q01344

Function: This is the receptor for interleukin-5. The alpha chain binds to IL5

Genatlas biochemistry entry for IL5RA:

interleukin 5,receptor,alpha subunit,with a membrane anchored and an alternatively spliced secreted form

heterodimerizing with CSF2RB

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0004896	cytokine receptor activity	--	--
GO:0004914	interleukin-5 receptor activity	TAS	1495999
GO:0005515	protein binding	IPI	1495999

IL5RA for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for IL5RA:

Synthetic lethal with Ras

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Il5ra):

cellular

hematopoietic system

immune system

renal/urinary system

tumorigenesis

IL5RA for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Il5ra^tm1Ktk for IL5RA

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IL5RA

miRNA Products:		OriGene 3'-UTR Clone (see all 6): IL5RA Browse MicroRNA Expression Plasmids
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		SwitchGear 3'UTR luciferase reporter plasmid: IL5RA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL5RA (see all 7) OriGene shRNA RFP: IL5RA OriGene siRNA: IL5RA
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		Sirion Biotech Custom design and validation of potent shRNA sequences against IL5RA

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IL5RA
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL5RA (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL5RA (see all 6) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): IL5RA (NM_175727)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL5RA

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Interleukin receptor SHC signaling

Interleukin receptor SHC signaling	1.00	Interleukin-3, 5 and GM-CSF signaling	0.57
Interleukin-2 signaling	0.67	The receptor is activated	0.29
Phosphorylated SHC1 recruits GRB2:GAB2	0.61	Signaling by Interleukins	0.25
SHC1 mediates cytokine-induced phosphorylation of GAB2	0.61

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Toll-like Receptor Pathway

Toll-like Receptor Pathway

1.00

MAPK Pathway

0.36

PEDF Induced Signaling

STAT3 Pathway

0.47

Cytokine-cytokine receptor interaction

0.26

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL5RA (see all 6)

	STAT3 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	p38 Signaling
	Akt Signaling

3 Tocris Bioscience Pathways for IL5RA

	Akt Pathway
	Toll-like Receptor Pathway
	MAPK Pathway

2 BioSystems Pathways for IL5RA

	IL-5 Signaling Pathway
	Inflammatory Response Pathway

5/9 Reactome Pathways for IL5RA (see all 9)

	SHC1 mediates cytokine-induced phosphorylation of GAB2
	Interleukin receptor SHC signaling
	Interleukin-2 signaling
	Phosphorylated SHC1 recruits GRB2:GAB2
	Cytokine Signaling in Immune system

3 Kegg Pathways (Kegg details for IL5RA):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	Hematopoietic cell lineage

IL5RA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL5RA

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/23 Interacting proteins for IL5RA (Q01344^{1, 3} ENSP00000256452⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL5	P05113¹^,³, ENSP00000231454⁴	EBI-1759442,EBI-2435811 I2D: score=4 STRING: ENSP00000231454
CSF2RB	P32927³, ENSP00000384053⁴	I2D: score=3 STRING: ENSP00000384053
SDCBP	O00560³, ENSP00000260130⁴	I2D: score=2 STRING: ENSP00000260130
UNC119	Q13432³, ENSP00000337040⁴	I2D: score=2 STRING: ENSP00000337040
JAK1	P23458³, ENSP00000343204⁴	I2D: score=2 STRING: ENSP00000343204

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002437	inflammatory response to antigenic stimulus	IEA	--
GO:0007165	signal transduction	TAS	1732409
GO:0008283	cell proliferation	TAS	1732409
GO:0032674	regulation of interleukin-5 production	IEA	--
GO:0038043	interleukin-5-mediated signaling pathway	TAS	1495999

IL5RA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL5RA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for IL5RA available from Tocris Bioscience About this table

Compound	Action	CAS #
Lyn peptide inhibitor	Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable	[222018-18-0]
YM 90709	Interleukin-5 receptor antagonist	[163769-88-8]

10 Novoseek chemical compound relationships for IL5RA gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gp 130	41.4	1	9030599 (1)
tyrosine	31.7	9	9257712 (1), 7935454 (1), 9254654 (1), 9558110 (1) (see all 6)
budesonide	22.5	3	11906363 (3)
retinoic acid	21.4	11	11306982 (3), 11842302 (2), 10224351 (1)
lysine	0	1	16430207 (1)
steroid	0	1	11906363 (1)
superoxide	0	1	18440651 (1)
alanine	0	2	16430207 (1), 15826943 (1)
arginine	0	2	9166423 (1), 15048779 (1)
dexamethasone	0	1	11724761 (1)

Search CenterWatch for drugs/clinical trials and news about IL5RA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL5RA gene (7 alternative transcripts):

NM_000564.4 NM_001243099.1 NM_175724.2 NM_175725.2 NM_175726.3 NM_175727.2 NM_175728.2

Unigene Cluster for IL5RA:

Interleukin 5 receptor, alpha

Hs.68876 [show with all ESTs]

Unigene Representative Sequence: NM_000564

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000446632(uc010hbp.3 uc010hbq.3 uc010hbr.3 uc011ask.2 uc010hbs.3 uc011asl.2)

ENST00000438560 ENST00000256452 ENST00000383846(uc011asm.1 uc010hbt.2)

ENST00000311981 ENST00000430514(uc011asn.1 uc010hbu.2) ENST00000456302

ENST00000445701 ENST00000427088 ENST00000466722 ENST00000418488 ENST00000445864

miRNA Products:		OriGene 3'-UTR Clone (see all 6): IL5RA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL5RA
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against IL5RA

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL5RA

Additional cDNA sequence:

AB288089.1 AB288090.1 AK304256.1 BC027599.2 M75914.1 M96651.1 M96652.1 X61176.1

X61178.1 X62156.1

11 DOTS entries:

DT.100741333 DT.92417078 DT.40114986 DT.65285778 DT.211057 DT.40114987 DT.75198483 DT.100672739

DT.455996 DT.91652381 DT.91959075

20 AceView cDNA sequences:

NM_175727 AI381503 NM_175726 NM_175725 NM_000564 NM_175724 NM_175728 BI829953

X61178 X62156 BI520196 M75914 M96652 BI520834 M96651 BC027599

X61176 AW005961 BG718717 X61177

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for IL5RA (see all 9) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	·	11c	·	11d	^	12a	·	12b	^	13	^	14	^	15	^	16a	·	16b
SP1:							-																												-		-		-		-						-
SP2:															-																				-		-		-		-						-
SP3:							-																												-		-
SP4:							-								-																				-		-
SP5:							-

ECgene alternative splicing isoforms for IL5RA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL5RA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGTTTCCC

About this image

IL5RA expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IL5RA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL5RA

SOURCE GeneReport for Unigene cluster: Hs.68876

UniProtKB/Swiss-Prot: IL5RA_HUMAN, Q01344

Tissue specificity: Expressed on eosinophils and basophils

SABiosciences Expression via Pathway-Focused PCR Arrays including IL5RA:

Interferons & Receptors in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Allergy & Asthma in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL5RA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL5RA
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL5RA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL5RA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL5RA gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il5ra^{1 , 5}	interleukin 5 receptor, alpha^{1, 5}	76.94(n)¹ 69.17(a)¹		6 (49.19 cM)⁵ 16192¹ NM_008370.2¹ NP_032396.1¹ 106711975⁵
chicken (Gallus gallus)	Aves	IL5RA¹	interleukin 5 receptor, alpha	56.04(n) 44.04(a)		771801 XM_001235030.2 XP_001235031.2

ENSEMBL Gene Tree for IL5RA (if available)
TreeFam Gene Tree for IL5RA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for IL5RA gene

IL13RA2² IL13RA1²

2 SIMAP similar genes for IL5RA using alignment to 8 protein entries: IL5RA_HUMAN (see all proteins):

HSIL5R3 HSIL5R2

IL5RA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138314423^1,2		--	3107570(+)	`GAGCCA/GAGACT`	3	--	ds500¹		0	--	--	--	--
rs182689785^1,2		--	3107632(+)	`TTCCAA/CCAGAG`	3	--	ds500¹		0	--	--	--	--
rs149651995^1,2		--	3107645(+)	`AGTTTC/TGGCAG`	3	--	ds500¹		0	--	--	--	--
rs187972604^1,2		--	3107673(+)	`GTAGCA/GTGGAG`	3	--	ds500¹		0	--	--	--	--
rs6794523^1,2	C,F,A,H	--	3107691(+)	`GAAATC/AATCAG`	3	--	ds500¹		23		NA NS EA WA CSA	2482
rs340827^1,2	C,F,A,H	--	3107730(+)	`TTTGGG/ATATGT`	3	--	ds500¹		12		MN NA WA CSA EA	560
rs116007225^1,2	F	--	3107786(+)	`AAAAGG/AAGCTT`	3	--	ds500¹		1		WA	118
rs192053149^1,2		--	3107825(+)	`GGCAGA/TTGTGC`	3	--	ds500¹		0	--	--	--	--
rs147137127^1,2		--	3107854(+)	`AAAGGA/GAGGAA`	3	--	ds500¹		0	--	--	--	--
rs183373427^1,2		--	3107862(+)	`GAAATA/CCTGGA`	3	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IL5RA (3111233 - 3168297 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for IL5RA
3 CNVs: 8407 5211 59134

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL5RA for disorders           About GeneDecksing

OMIM gene information: 147851    OMIM disorders: --

20/34 diseases for IL5RA (see all 34):    About MalaCards

chronic obstructive pulmonary disease eosinophilic esophagitis allergic rhinitis adult t-cell leukemia

atopic dermatitis acute lymphoblastic leukemia chronic lymphocytic leukemia multiple sclerosis

lymphoblastic leukemia eosinophilia lymphocytic leukemia atopy

rhinitis bronchiolitis mastocytosis cblc

pulmonary disease t-cell leukemia leukemia eczema

10/11 Novoseek disease relationships for IL5RA gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
eosinophilia	59.1	3	17914408 (1), 7577627 (1), 12759409 (1)
asthma	50.9	6	12759409 (1), 16217591 (1), 15372320 (1), 19170670 (1) (see all 5)
airways disease	40.2	1	15286446 (1)
promyelocytic leukemia	38.6	1	2388031 (1)
inflammation	31.1	3	10224351 (1), 12759409 (1), 17041908 (1)
atopy	24	1	15372320 (1)
asthma allergic	16.1	1	15248851 (1)
tumors	1	2	17592361 (1)
skin lesion	0	3	9723668 (2), 17620072 (1)
necrosis	0	2	17592361 (1)

Genetic Association Database (GAD): IL5RA
Human Genome Epidemiology (HuGE) Navigator: IL5RA (36 documents)

Export disorders for IL5RA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for IL5RA gene, integrated from 9 sources (see all 173):
(articles sorted by number of sources associating them with IL5RA)

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world of online information

Molecular cloning and expression of the human interleukin 5 receptor. (PubMed id 1732409)^{1, 2, 3, 9} Murata Y.... Takatsu K. (1992)
A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. (PubMed id 1833065)^{1, 2, 9} Tavernier J.... Plaetinck G. (1991)
Association analysis of interleukin 5 receptor alpha subunit (IL5RA) polymorphisms and asthma. (PubMed id 16217591)^{1, 4, 9} Cheong H.S....Shin H.D. (2005)
Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit. (PubMed id 1495999)^{1, 2, 9} Tavernier J.... Devos R. (1992)
Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease. (PubMed id 12082592)^{1, 4} Zee R.Y....Lindpainter K. (2002)
Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. (PubMed id 1427903)^{1, 9} Isobe M....Ogita Z. (1992)
Asymmetric usage of antagonist charged residues drives interleukin-5 receptor recruitment but is insufficient for receptor activation. (PubMed id 16430207)^{1, 9} Ishino T....Chaiken I. (2006)
Interleukin-5 receptor subunit oligomerization and rearrangement revealed by fluorescence resonance energy transfer imaging. (PubMed id 18326494)^{1, 9} Zaks-Zilberman M....Chaiken I.M. (2008)
The severity of FIP1L1-PDGFRA-positive chronic eosinophilic leukaemia is associated with polymorphic variation at the IL5RA locus. (PubMed id 17914408)^{1, 9} Burgstaller S....Cross N.C. (2007)
Identification of regions within the third FnIII-like domain of the IL-5Ralpha involved in IL-5 interaction. (PubMed id 10880230)^{1, 9} Czabotar P.E....Sanderson C.J. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3568	HGNC: 6017	AceView: IL5RA	Ensembl:ENSG00000091181	euGenes: HUgn3568
ECgene: IL5RA	Kegg: 3568	H-InvDB: IL5RA

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for IL5RA	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL5RA	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/il5ra/

Intellectual Property for IL5RA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IL5RA gene:
Search GeneIP for patents involving IL5RA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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interleukin 5 receptor, alpha

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IL5RA Gene

interleukin 5 receptor, alpha

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