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IL5RA Gene

protein-coding   GIFtS: 64
GCID: GC03M003111

Interleukin 5 Receptor, Alpha


(Previous symbol: IL5R)
  See IL5RA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 5 Receptor, Alpha1 2     HSIL5R32
IL5R1 2 3     Interleukin 5 Receptor Type 32
CDw1252 3     Interleukin-5 Receptor Alpha Chain2
CD125 Antigen2 3     Interleukin-5 Receptor Subunit Alpha2
IL-5 Receptor Subunit Alpha2 3     IL-5R-alpha3
IL-5R Subunit Alpha2 3     IL-5RA3
CD1252     

External Ids:    HGNC: 60171   Entrez Gene: 35682   Ensembl: ENSG000000911817   OMIM: 1478515   UniProtKB: Q013443   

Export aliases for IL5RA gene to outside databases

Previous GC identifers: GC03M003040 GC03M003086 GC03M003045


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL5RA Gene:
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The
receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the
receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The
binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding,
and is required for the biological activities of IL5. This protein has been found to interact with syndecan
binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4.
Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. (provided
by RefSeq, Jul 2011)

GeneCards Summary for IL5RA Gene:
IL5RA (interleukin 5 receptor, alpha) is a protein-coding gene. Diseases associated with IL5RA include atopy. GO annotations related to this gene include interleukin-5 receptor activity. An important paralog of this gene is IL13RA2.

UniProtKB/Swiss-Prot: IL5RA_HUMAN, Q01344
Function: This is the receptor for interleukin-5. The alpha chain binds to IL5

summary for IL5RA Gene:
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL5RA (Interleukin 5 receptor alpha subunit) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL5RA gene promoter:
         AML1a   CUTL1   RelA   Meis-1b   FOXL1   AREB6   FOXO4   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL5RA promoter sequence
   Search Chromatin IP Primers for IL5RA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL5RA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p26-p24   Ensembl cytogenetic band:  3p26.2   HGNC cytogenetic band: 3p26-p24

IL5RA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL5RA gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M003111:  view genomic region     (about GC identifiers)

Start:
3,111,233 bp from pter      End:
3,168,297 bp from pter
Size:
57,065 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IL5RA_HUMAN, Q01344 (See protein sequence)
Recommended Name: Interleukin-5 receptor subunit alpha precursor  
Size: 420 amino acids; 47685 Da
Subunit: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF
receptors. Interacts with SDCBP
4 PDB 3D structures from and Proteopedia for IL5RA:
1OBX (3D)        1OBZ (3D)        3QT2 (3D)        3VA2 (3D)    
Secondary accessions: B3IU77 B4E2G0 Q14633 Q15469 Q6ISX9
Alternative splicing: 5 isoforms:  Q01344-1   Q01344-2   Q01344-3   Q01344-4   Q01344-5   

Explore the universe of human proteins at neXtProt for IL5RA: NX_Q01344

Explore proteomics data for IL5RA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn35, Asn131, Asn216, Asn244
  • Modification sites at PhosphoSitePlus

  • See IL5RA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_000555.2  NP_001230028.1  NP_783851.1  NP_783852.1  NP_783853.1  NP_783854.1  NP_783855.1  

    ENSEMBL proteins: 
     ENSP00000412209   ENSP00000390753   ENSP00000256452   ENSP00000373358   ENSP00000309196  
     ENSP00000400400   ENSP00000392059   ENSP00000398117   ENSP00000391274   ENSP00000388858  
     ENSP00000402598  
    Reactome Protein details: Q01344

    IL5RA Human Recombinant Protein Products:

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    antibodies-online proteins for IL5RA (5 products) 

     
    antibodies-online peptides for IL5RA

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    antibodies-online kits for IL5RA (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 5 receptor, alpha subunit
    IL-3 receptor family

    4 InterPro protein domains:
     IPR015321 IL-6_rcpt_alpha-bd
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR003532 Short_hematopoietin_rcpt_2_CS

    Graphical View of Domain Structure for InterPro Entry Q01344

    ProtoNet protein and cluster: Q01344

    1 Blocks protein domain: IPB003532 Short hematopoietin receptor

    UniProtKB/Swiss-Prot: IL5RA_HUMAN, Q01344
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Domain: The box 1 motif is required for JAK interaction and/or activation
    Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily
    Similarity: Contains 2 fibronectin type-III domains


    Find genes that share domains with IL5RA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL5RA_HUMAN, Q01344
    Function: This is the receptor for interleukin-5. The alpha chain binds to IL5

         Genatlas biochemistry entry for IL5RA:
    interleukin 5,receptor,alpha subunit,with a membrane anchored and an alternatively spliced secreted form
    heterodimerizing with CSF2RB

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004896cytokine receptor activity ----
    GO:0004914interleukin-5 receptor activity TAS1495999
    GO:0005515protein binding IPI1495999
         
    Find genes that share ontologies with IL5RA           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IL5RA:
     Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il5ra):
     hematopoietic system  immune system  renal/urinary system  tumorigenesis 

    Find genes that share phenotypes with IL5RA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il5ratm1Ktk for IL5RA

       genOway: Develop your customized and physiologically relevant rodent model for IL5RA

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL5RA_HUMAN, Q01344: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane4
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS1495999
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with IL5RA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL5RA About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    2Signaling by Interleukins
    Interleukin receptor SHC signaling0.67
    Interleukin-3, 5 and GM-CSF signaling0.59
    Interleukin-2 signaling0.67
    Signaling by Interleukins0.42
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4MAPK Pathway
    Toll-like Receptor Pathway0.36
    MAPK Pathway0.36
    5Interferon Signaling
    Cytokine Signaling in Immune system0.59


    Find genes that share SuperPaths with IL5RA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL5RA (see all 6)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling

    3 Tocris Bioscience Pathways for IL5RA
        Akt Pathway
    Toll-like Receptor Pathway
    MAPK Pathway

    2 BioSystems Pathways for IL5RA
        IL-5 Signaling Pathway
    Inflammatory Response Pathway


    2 Reactome Pathways for IL5RA
        Interleukin receptor SHC signaling
    Interleukin-3, 5 and GM-CSF signaling


    3 Kegg Pathways  (Kegg details for IL5RA):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Hematopoietic cell lineage

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL5RA: 
              Interferons & Receptors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL5RA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for IL5RA (Q013441, 3 ENSP000002564524) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL5P051131, 3, ENSP000002314544EBI-1759442,EBI-2435811 I2D: score=4 STRING: ENSP00000231454
    CSF2RBP329273, ENSP000003840534I2D: score=3 STRING: ENSP00000384053
    SDCBPO005603, ENSP000002601304I2D: score=2 STRING: ENSP00000260130
    UNC119Q134323, ENSP000003370404I2D: score=2 STRING: ENSP00000337040
    JAK1P234583, ENSP000003432044I2D: score=2 STRING: ENSP00000343204
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002437inflammatory response to antigenic stimulus IEA--
    GO:0007165signal transduction TAS1732409
    GO:0008283cell proliferation TAS1732409
    GO:0032674regulation of interleukin-5 production IEA--
    GO:0038043interleukin-5-mediated signaling pathway TAS1495999

    Find genes that share ontologies with IL5RA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for IL5RA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
    PirfenidoneAntifibrotic agent; regulates cytokine levels in vivo[53179-13-8]
    GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines[6501-72-0]
    4-IPPInhibitor of macrophage migration inhibitory factor (MIF); suicide substrate[41270-96-6]
    ThalidomideTNF-alpha synthesis inhibitor[50-35-1]

    1 IUPHAR Ligand for IL5RA (Interleukin 5 receptor, alpha subunit)    About this table
    LigandTypeActionAffinityPubmed IDs
    IL-5
    AgonistAgonist--

    10 Novoseek inferred chemical compound relationships for IL5RA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 41.4 1 9030599 (1)
    tyrosine 31.7 9 9257712 (1), 7935454 (1), 9254654 (1), 9558110 (1) (see all 6)
    budesonide 22.5 3 11906363 (3)
    retinoic acid 21.4 11 11306982 (3), 11842302 (2), 10224351 (1)
    lysine 0 1 16430207 (1)
    steroid 0 1 11906363 (1)
    superoxide 0 1 18440651 (1)
    alanine 0 2 16430207 (1), 15826943 (1)
    arginine 0 2 9166423 (1), 15048779 (1)
    dexamethasone 0 1 11724761 (1)



    Find genes that share compounds with IL5RA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL5RA gene (7 alternative transcripts): 
    NM_000564.4  NM_001243099.1  NM_175724.2  NM_175725.2  NM_175726.3  NM_175727.2  NM_175728.2  

    Unigene Cluster for IL5RA:

    Interleukin 5 receptor, alpha
    Hs.68876  [show with all ESTs]
    Unigene Representative Sequence: NM_000564
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446632(uc010hbp.3 uc010hbq.3 uc010hbr.3 uc011ask.2 uc010hbs.3 uc011asl.2)
    ENST00000438560 ENST00000256452 ENST00000383846(uc011asm.1 uc010hbt.2)
    ENST00000311981 ENST00000430514(uc011asn.1 uc010hbu.2) ENST00000456302
    ENST00000445701 ENST00000427088 ENST00000466722 ENST00000418488 ENST00000445864

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    Additional mRNA sequence: 

    AB288089.1 AB288090.1 AK304256.1 BC027599.2 M75914.1 M96651.1 M96652.1 X61176.1 
    X61178.1 X62156.1 

    11 DOTS entries:

    DT.100741333  DT.92417078  DT.40114986  DT.65285778  DT.211057  DT.40114987  DT.75198483  DT.100672739 
    DT.455996  DT.91652381  DT.91959075 

    20 AceView cDNA sequences:

    NM_175725 NM_175726 NM_000564 NM_175728 NM_175727 NM_175724 AI381503 X62156 
    M96651 BI829953 M75914 BI520196 X61178 BI520834 X61176 BC027599 
    M96652 AW005961 BG718717 X61177 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IL5RA (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                    -                                                                                   -     -     -     -                 -               
    SP2:                                            -                                                           -     -     -     -                 -               
    SP3:                    -                                                                                   -     -                                             
    SP4:                    -                       -                                                           -     -                                             
    SP5:                    -                                                                                                                                       


    ECgene alternative splicing isoforms for IL5RA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL5RA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGTTTCCC
    IL5RA Expression
    About this image


    IL5RA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    IL5RA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL5RA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.68876

    UniProtKB/Swiss-Prot: IL5RA_HUMAN, Q01344
    Tissue specificity: Expressed on eosinophils and basophils

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL5RA: 
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              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL5RA gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il5ra1 , 5 interleukin 5 receptor, alpha1, 5 76.94(n)1
    69.17(a)1
      6 (49.19 cM)5
    161921  NM_008370.21  NP_032396.11 
     1067119755 
    chicken
    (Gallus gallus)
    Aves IL5RA1 interleukin 5 receptor, alpha 55.96(n)
    44.04(a)
      771801  NM_001256152.1  NP_001243081.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia il5ra1 interleukin 5 receptor, alpha 46.36(n)
    34.43(a)
      100144707  NM_001123462.1  NP_001116934.1 


    ENSEMBL Gene Tree for IL5RA (if available)
    TreeFam Gene Tree for IL5RA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL5RA gene
    IL13RA22  IL13RA12  
    2 SIMAP similar genes for IL5RA using alignment to 6 protein entries:     IL5RA_HUMAN (see all proteins):
    HSIL5R2    HSIL5R3

    Find genes that share paralogs with IL5RA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL5RA (see all 1404)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383144231,2
    C--3043695(+) GAGCCA/GAGACT 3 -- ds50010--------
    rs1826897851,2
    --3043757(+) TTCCAA/CCAGAG 3 -- ds50010--------
    rs1496519951,2
    --3043770(+) AGTTTC/TGGCAG 3 -- ds50010--------
    rs1879726041,2
    --3043798(+) GTAGCA/GTGGAG 3 -- ds50010--------
    rs67945231,2
    C,F,A,H--3043816(+) GAAATC/AATCAG 3 -- ds500123Minor allele frequency- A:0.37NA NS EA WA CSA 2482
    rs3408271,2
    C,F,A,H--3043855(+) TTTGGG/ATATGT 3 -- ds500112Minor allele frequency- A:0.41MN NA WA CSA EA 560
    rs1160072251,2
    C,F--3043911(+) AAAAGG/AAGCTT 3 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1920531491,2
    --3043950(+) GGCAGA/TTGTGC 3 -- ds50010--------
    rs1471371271,2
    --3043979(+) AAAGGA/GAGGAA 3 -- ds50010--------
    rs1833734271,2
    --3043987(+) GAAATA/CCTGGA 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for IL5RA (3111233 - 3168297 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for IL5RA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422274CNV Duplication17116639
    nsv521796CNV Loss19592680
    nsv819643CNV Loss19587683
    nsv876405CNV Gain21882294
    nsv518298CNV Gain19592680
    esv2751994CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147851    OMIM disorders: --

    1 disease for IL5RA:    
    About MalaCards
    atopy


    Find genes that share disorders with IL5RA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL5RA gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    eosinophilia 59.1 3 17914408 (1), 7577627 (1), 12759409 (1)
    asthma 50.9 6 12759409 (1), 16217591 (1), 15372320 (1), 19170670 (1) (see all 5)
    airways disease 40.2 1 15286446 (1)
    promyelocytic leukemia 38.6 1 2388031 (1)
    inflammation 31.1 3 10224351 (1), 12759409 (1), 17041908 (1)
    atopy 24 1 15372320 (1)
    asthma allergic 16.1 1 15248851 (1)
    tumors 1 2 17592361 (1)
    skin lesion 0 3 9723668 (2), 17620072 (1)
    necrosis 0 2 17592361 (1)

    Genetic Association Database (GAD): IL5RA
    Human Genome Epidemiology (HuGE) Navigator: IL5RA (36 documents)

    Export disorders for IL5RA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL5RA gene, integrated from 10 sources (see all 181):
    (articles sorted by number of sources associating them with IL5RA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of the human interleukin 5 receptor. (PubMed id 1732409)1, 2, 3, 9 Murata Y.... Takatsu K. (J. Exp. Med. 1992)
    2. The severity of FIP1L1-PDGFRA-positive chronic eosinophilic leukaemia is associated with polymorphic variation at the IL5RA locus. (PubMed id 17914408)1, 4, 9 Burgstaller S....Cross N.C. (Leukemia 2007)
    3. A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. (PubMed id 1833065)1, 2, 9 Tavernier J.... Plaetinck G. (Cell 1991)
    4. Association analysis of interleukin 5 receptor alpha subunit (IL5RA) polymorphisms and asthma. (PubMed id 16217591)1, 4, 9 Cheong H.S....Shin H.D. (J. Hum. Genet. 2005)
    5. Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit. (PubMed id 1495999)1, 2, 9 Tavernier J.... Devos R. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    6. IL-5 and IL-5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans. (PubMed id 17620072)1, 4, 9 Namkung J.H....Yang J.M. (Allergy 2007)
    7. Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5RI+. (PubMed id 22153509)1, 2 Patino E....Mueller T.D. (Structure 2011)
    8. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients. (PubMed id 20536507)1, 4 Wang Y....Chan J.C. (Diabet. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3568 HGNC: 6017 AceView: IL5RA Ensembl:ENSG00000091181 euGenes: HUgn3568
    ECgene: IL5RA Kegg: 3568 H-InvDB: IL5RA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL5RA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL5RA Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/il5ra/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL5RA gene:
    Search GeneIP for patents involving IL5RA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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