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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL5 Gene

protein-coding   GIFtS: 63
GCID: GC05M131881

Interleukin 5 (Colony-Stimulating Factor, Eosinophil)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 5 (Colony-Stimulating Factor, Eosinophil)1 2     TRF2 3
T-Cell Replacing Factor1 2 3     B-Cell Differentiation Factor I2 3
Eosinophil Differentiation Factor1 2 3     B Cell Differentiation Factor I1
interleukin-51 2     EDF2
IL-52 3     

External Ids:    HGNC: 60161   Entrez Gene: 35672   Ensembl: ENSG000001135257   OMIM: 1478505   UniProtKB: P051133   

Export aliases for IL5 gene to outside databases

Previous GC identifers: GC05M131399 GC05M132324 GC05M131907 GC05M131953 GC05M131905 GC05M127069


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL5 Gene:
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils.
The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and
survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent
inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta
subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This
gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13
(IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements
spread over 120 kilobases on chromosome 5q31. (provided by RefSeq, Jul 2013)

GeneCards Summary for IL5 Gene: 
IL5 (interleukin 5 (colony-stimulating factor, eosinophil)) is a protein-coding gene. Diseases associated with IL5 include eosinophilia, and eosinophilic pneumonia, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Regulation of eIF4 and p70S6K. GO annotations related to this gene include growth factor activity and interleukin-5 receptor binding.

UniProtKB/Swiss-Prot: IL5_HUMAN, P05113
Function: Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting
cells

summary for IL5 Gene:
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL5 (Interleukin 5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL5 gene promoter:
         GR   GATA-3   GR-beta   POU3F2 (N-Oct-5b)   GR-alpha   C/EBPalpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL5 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q23-q31

IL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL5 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M131881:  view genomic region     (about GC identifiers)

Start:
131,877,136 bp from pter      End:
131,892,530 bp from pter
Size:
15,395 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL5_HUMAN, P05113 (See protein sequence)
Recommended Name: Interleukin-5 precursor  
Size: 134 amino acids; 15238 Da
Subunit: Homodimer; disulfide-linked
Subcellular location: Secreted
3 PDB 3D structures from and Proteopedia for IL5:
1HUL (3D)        3QT2 (3D)        3VA2 (3D)    
Secondary accessions: Q13840

Explore the universe of human proteins at neXtProt for IL5: NX_P05113

Explore proteomics data for IL5 at MOPED 

IL5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IL5 Protein Expression

REFSEQ proteins: NP_000870.1  
ENSEMBL proteins: 
 ENSP00000231454   ENSP00000409825  
Reactome Protein details: P05113
Human Recombinant Protein Products for IL5: 
EMD Millipore Purified and/or Recombinant IL5 Protein
R&D Systems Recombinant & Natural Proteins for IL5 (IL-5)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for IL5
OriGene Custom MassSpec 
OriGene Custom Protein Services for IL5
GenScript Purified and Recombinant Proteins for IL5
Novus Biologicals IL5 Proteins
Sino Biological Recombinant Protein for IL5
Sino Biological Cell Lysate for IL5 
ProSpec Recombinant Protein for IL5
Cloud-Clone Corp. Proteins for IL5 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space TAS3024129

IL5 for ontologies           About GeneDecksing



IL5 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for IL5 (IL-5)
Browse OriGene Antibodies
OriGene Custom Antibody Services for IL5
GenScript Custom Superior Antibodies Services for IL5
Novus Biologicals IL5 Antibodies
Abcam antibodies for IL5
Cloud-Clone Corp. Antibodies for IL5 
ThermoFisher Antibody for IL5
LSBio Antibodies in human, mouse, rat for IL5 

Assay Products for IL5: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IL5
R&D Systems ELISAs for IL5 (IL-5)         (see all)
GenScript Custom Assay Services for IL5
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for IL5 
Cloud-Clone Corp. CLIAs for IL5


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IL: Interleukins and interleukin receptors

3 InterPro protein domains:
 IPR012351 4_helix_cytokine_core
 IPR000186 Interleukin_5
 IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry P05113

ProtoNet protein and cluster: P05113

1 Blocks protein domain: IPB000186 Interleukin-5 signature

UniProtKB/Swiss-Prot: IL5_HUMAN, P05113
Similarity: Belongs to the IL-5 family


IL5 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL5_HUMAN, P05113
Function: Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting
cells

     Genatlas biochemistry entry for IL5:
interleukin 5,colony-stimulating factor (eosinophil),homodimerizing,inducing terminal differentiation of B cells
to immunoglobulin secreting cells

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0005137interleukin-5 receptor binding IEA--
GO:0005515protein binding IPI1495999
GO:0008083growth factor activity IEA--
     
IL5 for ontologies           About GeneDecksing


Phenotypes:
     11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Il5):
 behavior/neurological  digestive/alimentary  embryogenesis  growth/size  hematopoietic system 
 homeostasis/metabolism  immune system  liver/biliary system  reproductive system  respiratory system 
 tumorigenesis 

IL5 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for IL5: Il5tm1Kopf Il5tm1Anjm Il5tm3Anjm Il5tm2Anjm

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IL5 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL5

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL5 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL5 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL5
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL5
SwitchGear 3'UTR luciferase reporter plasmidIL5 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL5
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL5

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IL5
Sirion Biotech Customized adenovirus for overexpression of IL5

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for IL5 (see all 6)
OriGene ORF clones in mouse, rat for IL5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL5 (NM_000879)
Sino Biological Human cDNA Clone for IL5
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL5
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL5
Sirion Biotech Customized lentivirus for stable overexpression of IL5 
                     Customized lentivirus expression plasmids for stable overexpression of IL5 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IL5
Search LifeMap BioReagents cell lines for IL5
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL5


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IL5 About   (see all 27)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Regulation of Innate Immune Cells0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2TGF-Beta Pathway
TGF-Beta Pathway0.60
Regulation of eIF4 and p70S6K0.43
MAPK Family Pathway0.60
SOCS Pathway0.40
JAK-STAT Pathway0.57
3Allograft rejection
Allograft rejection0.69
Asthma0.47
Autoimmune thyroid disease0.62
Intestinal immune network for IgA production0.42
4Interleukin-3, 5 and GM-CSF signaling
Interleukin receptor SHC signaling0.67
Interleukin-3, 5 and GM-CSF signaling0.57
Interleukin-2 signaling0.67
Signaling by Interleukins0.45
5Akt Signaling
Akt Signaling0.60
Tec Kinases Signaling0.55
p38 Signaling0.60

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for IL5
    Selected targets of GCR-alpha

1 R&D Systems Pathway for IL5
    IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/26 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL5 (see all 26)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions
Tec Kinases Signaling

3 Tocris Bioscience Pathways for IL5
    Akt Pathway
Toll-like Receptor Pathway
MAPK Pathway

5/7 BioSystems Pathways for IL5 (see all 7)
    Cytokines and Inflammatory Response
IL-5 Signaling Pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Glucocorticoid receptor regulatory network
IL4-mediated signaling events


5/6        Reactome Pathways for IL5 (see all 6)
    Interleukin receptor SHC signaling
Interleukin-2 signaling
Cytokine Signaling in Immune system
Interleukin-3, 5 and GM-CSF signaling
Signaling by Interleukins


5/10         Kegg Pathways  (Kegg details for IL5) (see all 10):
    Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
T cell receptor signaling pathway
Fc epsilon RI signaling pathway


IL5 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/29 Interacting proteins for IL5 (P051131, 3 ENSP000002314544) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
InteractantInteraction Details
GeneCardExternal ID(s)
CSF2RBP329271, 3, ENSP000003840534EBI-2435811,EBI-1809771 I2D: score=1 STRING: ENSP00000384053
IL5RAQ013441, 3, ENSP000002564524EBI-2435811,EBI-1759442 I2D: score=4 STRING: ENSP00000256452
ETS1ENSP000003764364STRING: ENSP00000376436
FOSENSP000003062454STRING: ENSP00000306245
GATA3ENSP000003686324STRING: ENSP00000368632
About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006954inflammatory response IEA--
GO:0006955immune response IEA--
GO:0008284positive regulation of cell proliferation ----
GO:0019221cytokine-mediated signaling pathway IEA--
GO:0030890positive regulation of B cell proliferation IEA--

IL5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL5 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for IL5 available from Tocris Bioscience    About this table
CompoundAction CAS #
AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
PirfenidoneAntifibrotic agent; regulates cytokine levels in vivo[53179-13-8]
GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines[6501-72-0]
4-IPPInhibitor of macrophage migration inhibitory factor (MIF); suicide substrate[41270-96-6]
ThalidomideTNF-alpha synthesis inhibitor[50-35-1]

1 DrugBank Compound for IL5    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Pranlukast-- 103177-37-3targetantagonist12692940 15650315 11972613 16892782 10773010

10/129 Novoseek inferred chemical compound relationships for IL5 gene (see all 129)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
mepolizumab 85.3 32 11496242 (4), 18410960 (2), 19426126 (1), 12870444 (1) (see all 20)
rantes 82.4 224 10378529 (6), 8998072 (5), 8626989 (5), 19522185 (5) (see all 99)
sch 55700 75.5 5 12649124 (2), 17364206 (1), 15577851 (1), 17088140 (1)
allergens 74.2 34 16433854 (2), 19058497 (2), 9554118 (1), 9590218 (1) (see all 31)
il 10 67.2 35 8310699 (2), 16943231 (2), 17928005 (2), 12191514 (2) (see all 28)
ionomycin 66.3 37 1493921 (2), 7664804 (1), 9095665 (1), 9503684 (1) (see all 35)
tarc 64.5 21 17165591 (4), 18395252 (3), 11956056 (2), 10050676 (1) (see all 15)
sophoricoside 62.7 2 11106000 (2)
histamine 61.6 125 7879707 (7), 7522070 (6), 7543541 (4), 1701820 (4) (see all 68)
methacholine 59.2 35 18217313 (2), 9445301 (2), 16642575 (2), 9399955 (1) (see all 19)

Search CenterWatch for drugs/clinical trials and news about IL5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL5 gene: 
NM_000879.2  

Unigene Cluster for IL5:

Interleukin 5 (colony-stimulating factor, eosinophil)
Hs.2247  [show with all ESTs]
Unigene Representative Sequence: DQ655974
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000231454(uc003kxe.1) ENST00000462418 ENST00000450655
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL5
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL5
SwitchGear 3'UTR luciferase reporter plasmidIL5 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL5
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL5
Clone
Products:
     
OriGene clones in human, mouse for IL5 (see all 6)
OriGene ORF clones in mouse, rat for IL5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL5 (NM_000879)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL5
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL5
Sirion Biotech Customized lentivirus for stable overexpression of IL5 
                     Customized lentivirus expression plasmids for stable overexpression of IL5 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for IL5
OriGene qSTAR qPCR primer pairs in human, mouse for IL5
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL5
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL5
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL5

Additional mRNA sequence: 

BC066279.1 BC066280.1 BC066281.1 BC066282.1 BC069137.1 DQ655971.2 DQ655974.2 X04688.1 
X12705.1 

2 DOTS entries:

DT.100761466  DT.120846100 

15 AceView cDNA sequences:

CD559686 NM_000879 BC066281 BC069137 X04688 X12705 BC066280 BC066282 
BC066279 CD559532 CD559535 CD559534 CD559536 CD559533 CD559608 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL5 expression in normal human tissues (normalized intensities)      IL5 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGGATGCTTC
IL5 Expression
About this image


IL5 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/9 selected tissues (see all 9) fully expand
 
 Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
         rectum ; glandular cells   
 
 Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
         small intestine ; glandular cells   
 
 Epithelium (Uncategorized)    fully expand to see all 2 entries
         oral mucosa ; squamous epithelial cells   
 
 Nose (Sensory Organs)
         nasopharynx ; respiratory epithelial cells   
 
 Uterus (Reproductive System)
         uterus, post-menopause ; glandular cells   

See IL5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL5

SOURCE GeneReport for Unigene cluster: Hs.2247
    SABiosciences Expression via Pathway-Focused PCR Arrays including IL5 (see all 15): 
          Fibrosis in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat
          T-cell & B-cell Activation in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Innate & Adaptive Immune Responses in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for IL5
OriGene qSTAR qPCR primer pairs in human, mouse for IL5
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL5
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL5
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL5
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for IL5 gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il51 , 5 interleukin 51, 5 78.72(n)1
71.54(a)1
  11 (31.99 cM)5
161911  NM_010558.11  NP_034688.11 
 537207945 


ENSEMBL Gene Tree for IL5 (if available)
TreeFam Gene Tree for IL5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/147 SNPs in IL5 are shown (see all 147)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs100654761,2
C--132153435(+) CAGGGT/ACAGGT 1 -- ds50011Minor allele frequency- A:0.00EA 180
rs727973451,2
C--132153472(+) CAGAGA/GGGGTT 1 -- ds50010--------
rs1453890731,2
--132153490(+) TCCTCC/TCTATA 1 -- ds50010--------
rs1480070371,2
--132153555(+) TTACAA/GGTTCC 1 -- ds50010--------
rs1417375671,2
--132153582(+) CAGGGG/TACGCC 1 -- ds50010--------
rs1115621071,2
F--132153611(+) CTACAG/ATCAGT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
rs1177887141,2
F--132153698(+) GAAAAC/TCAGGT 1 -- ds50011Minor allele frequency- T:0.01EA 120
rs1386555371,2
C--132154131(+) GCAAAG/TTGTCA 1 -- ut310--------
rs567537281,2
C--132154180(+) TATACC/TGAAAA 1 -- ut311Minor allele frequency- T:0.50WA 2
rs20698181,2
C,F,O,H--132154298(-) AACACC/AGAGTG 2 /T syn1 ese328Minor allele frequency- A:0.04NS EA NA MN WA 7306

HapMap Linkage Disequilibrium report for IL5 (131877136 - 131892530 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for IL5: --

Human Gene Mutation Database (HGMD): IL5
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IL5
DNA2.0 Custom Variant and Variant Library Synthesis for IL5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 147850    OMIM disorders: --

20/228 diseases for IL5 (see all 228):    About MalaCards
eosinophilia    eosinophilic pneumonia    gastroenteritis    eosinophilic gastroenteritis
strongyloidiasis    familial eosinophilia    eosinophilia-myalgia syndrome    eosinophilic fasciitis
necatoriasis    eosinophilic meningitis    eosinophilic gastritis    bagassosis
scleritis    eosinophilic esophagitis    kimura disease    pulmonary eosinophilia
chronic eosinophilic pneumonia    paragonimiasis    atopic keratoconjunctivitis    fasciitis

10 diseases from the University of Copenhagen DISEASES database for IL5:
Eosinophilia     Asthma     Allergic rhinitis     Eosinophilic esophagitis
Hypersensitivity reaction type I disease     Dermatitis     Churg-Strauss syndrome     Kimura disease
Filariasis     Eosinophilic gastroenteritis

IL5 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

10/97 Novoseek inferred disease relationships for IL5 gene (see all 97)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
eosinophilia 91.9 508 9990366 (9), 10802841 (6), 17160990 (5), 2373861 (5) (see all 99)
asthma 86.9 674 9493449 (9), 15805995 (7), 12915771 (6), 7499683 (5) (see all 99)
asthma allergic 84.7 80 15805995 (4), 11842300 (3), 14521755 (2), 10069881 (2) (see all 56)
hypereosinophilic syndrome 81.7 23 8608231 (2), 1753511 (1), 8906227 (1), 16418325 (1) (see all 20)
inflammation 80.3 281 1401075 (3), 9284977 (2), 9751843 (2), 10939534 (2) (see all 99)
dermatitis atopic 78.5 81 14581138 (4), 7523534 (3), 11886533 (3), 9164367 (3) (see all 56)
nasal polyps 78.5 138 16929824 (6), 12916352 (5), 12563937 (4), 12768697 (4) (see all 54)
allergic rhinitis 77.4 93 17438848 (5), 16722389 (4), 10852530 (4), 11884474 (3) (see all 47)
allergy 76.4 69 7819742 (4), 8203203 (2), 17642139 (2), 9338549 (1) (see all 54)
pulmonary eosinophilia 72.3 15 1475542 (1), 10030835 (1), 7613159 (1), 17996260 (1) (see all 13)

Genetic Association Database (GAD): IL5
Human Genome Epidemiology (HuGE) Navigator: IL5 (63 documents)

Export disorders for IL5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IL5 gene, integrated from 9 sources (see all 2538):
(articles sorted by number of sources associating them with IL5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5). (PubMed id 3498940)1, 2, 3 Campbell H.D.... Young I.G. (1987)
  2. IL-5 and thromboxane A2 receptor gene polymorphisms are associated with decreased pulmonary function in Korean children with atopic asthma. (PubMed id 15805995)1, 4, 9 Hong S.J....Hong T.J. (2005)
  3. Analysis of Polymorphisms in Olive Pollen Allergy: IL13, IL4RA, IL5 and ADRB2 Genes. (PubMed id 18849614)1, 4, 9 Llanes E....Cardaba B. (2008)
  4. Heterogeneity of interleukin 5 genetic background in atopic dermatitis patients: significant difference between those with blood eosinophilia and normal eosinophil levels. (PubMed id 14581138)1, 4, 9 Yamamoto N....Uehara M. (2003)
  5. Polymorphisms in eosinophil pathway genes, asthma and atopy. (PubMed id 17362254)1, 4, 9 Kabesch M....Nickel R. (2007)
  6. Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum. (PubMed id 18056382)1, 4, 9 Ellis M.K....McManus D.P. (2007)
  7. IL-5 and IL-5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans. (PubMed id 17620072)1, 4, 9 Namkung J.H....Yang J.M. (2007)
  8. Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma. (PubMed id 16449530)1, 4, 9 Lan Q....Chanock S. (2006)
  9. Risk of small-for-gestational age is associated with common anti-inflammatory cytokine polymorphisms. (PubMed id 15951665)1, 4, 9 Engel S.A....Chanock S.J. (2005)
  10. Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. (PubMed id 15007355)1, 4, 9 Hoffjan S....Ober C. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
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  Query String
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OMIM
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3567 HGNC: 6016 AceView: IL5 Ensembl:ENSG00000113525 euGenes: HUgn3567
ECgene: IL5 Kegg: 3567 H-InvDB: IL5

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IL5 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL5 Genetics and Cytogenetics in Oncology and Haematology
R&D Systems' cytokine mini-reviews: IL-5http://www.rndsystems.com/molecule_detail.aspx?m=1646
Wikipedia http://en.wikipedia.org/wiki/Interleukin_5
SeattleSNPshttp://pga.gs.washington.edu/data/il5/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IL5 gene:
Search GeneIP for patents involving IL5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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