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IL5 Gene

protein-coding   GIFtS: 64
GCID: GC05M131881

Interleukin 5 (Colony-Stimulating Factor, Eosinophil)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 5 (Colony-Stimulating Factor, Eosinophil)1 2     TRF2 3
T-Cell Replacing Factor1 2 3     B-Cell Differentiation Factor I2 3
Eosinophil Differentiation Factor1 2 3     B Cell Differentiation Factor I1
interleukin-51 2     EDF2
IL-52 3     

External Ids:    HGNC: 60161   Entrez Gene: 35672   Ensembl: ENSG000001135257   OMIM: 1478505   UniProtKB: P051133   

Export aliases for IL5 gene to outside databases

Previous GC identifers: GC05M131399 GC05M132324 GC05M131907 GC05M131953 GC05M131905 GC05M127069


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL5 Gene:
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils.
The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and
survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent
inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta
subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This
gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13
(IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements
spread over 120 kilobases on chromosome 5q31. (provided by RefSeq, Jul 2013)

GeneCards Summary for IL5 Gene:
IL5 (interleukin 5 (colony-stimulating factor, eosinophil)) is a protein-coding gene. Diseases associated with IL5 include pulmonary eosinophilia, and eosinophilia-myalgia syndrome. GO annotations related to this gene include interleukin-5 receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IL5_HUMAN, P05113
Function: Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting
cells

summary for IL5 Gene:
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL5 (Interleukin 5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL5 gene promoter:
         GR   GATA-3   GR-beta   POU3F2 (N-Oct-5b)   GR-alpha   C/EBPalpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL5 promoter sequence
   Search Chromatin IP Primers for IL5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q23-q31

IL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL5 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M131881:  view genomic region     (about GC identifiers)

Start:
131,877,136 bp from pter      End:
131,892,530 bp from pter
Size:
15,395 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL5_HUMAN, P05113 (See protein sequence)
Recommended Name: Interleukin-5 precursor  
Size: 134 amino acids; 15238 Da
Subunit: Homodimer; disulfide-linked
3 PDB 3D structures from and Proteopedia for IL5:
1HUL (3D)        3QT2 (3D)        3VA2 (3D)    
Secondary accessions: Q13840

Explore the universe of human proteins at neXtProt for IL5: NX_P05113

Explore proteomics data for IL5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr22, Asn47

  • See IL5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000870.1  
    ENSEMBL proteins: 
     ENSP00000231454   ENSP00000409825  
    Reactome Protein details: P05113

    IL5 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IL5 Protein
    R&D Systems Recombinant & Natural Proteins for IL5 (IL-5)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IL5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IL5
    GenScript Purified and Recombinant Proteins for IL5
    Novus Biologicals IL5 Proteins
    Sino Biological Recombinant Protein for IL5
    Sino Biological Cell Lysate for IL5
    ProSpec Recombinant Protein for IL5
    Cloud-Clone Corp. Proteins for IL5

    IL5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL5
    R&D Systems Antibodies for IL5 (IL-5)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IL5
    Novus Biologicals IL5 Antibodies
    Abcam antibodies for IL5
    Cloud-Clone Corp. Antibodies for IL5
    ThermoFisher Antibody for IL5
    LSBio Antibodies in human, mouse, rat for IL5

    IL5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL5
    R&D Systems ELISAs for IL5 (IL-5)         (see all)
    GenScript Custom Assay Services for IL5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL5
    Cloud-Clone Corp. CLIAs for IL5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    3 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR000186 IL-5
     IPR009079 4_helix_cytokine-like_core

    Graphical View of Domain Structure for InterPro Entry P05113

    ProtoNet protein and cluster: P05113

    1 Blocks protein domain: IPB000186 Interleukin-5 signature

    UniProtKB/Swiss-Prot: IL5_HUMAN, P05113
    Similarity: Belongs to the IL-5 family


    IL5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL5_HUMAN, P05113
    Function: Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting
    cells

         Genatlas biochemistry entry for IL5:
    interleukin 5,colony-stimulating factor (eosinophil),homodimerizing,inducing terminal differentiation of B cells
    to immunoglobulin secreting cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005137interleukin-5 receptor binding IEA--
    GO:0005515protein binding IPI1495999
    GO:0008083growth factor activity IEA--
         
    IL5 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Il5):
     behavior/neurological  digestive/alimentary  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  reproductive system  respiratory system 
     tumorigenesis 

    IL5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL5: Il5tm1Kopf Il5tm1Anjm Il5tm3Anjm Il5tm2Anjm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL5

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL5:
    hsa-mir-454-5p (MIRT039253), hsa-mir-335-5p (MIRT017691)

    Block miRNA regulation of human, mouse, rat IL5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IL5
    SwitchGear 3'UTR luciferase reporter plasmidIL5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL5
    Predesigned siRNA for gene silencing in human, mouse, rat IL5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL5

    Clone
    Products:
         
    OriGene clones in human, mouse for IL5 (see all 6)
    OriGene ORF clones in mouse, rat for IL5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL5 (NM_000879)
    Sino Biological Human cDNA Clone for IL5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL5

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IL5
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL5_HUMAN, P05113: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane2
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS3024129

    IL5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL5 About   (see all 26)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Allograft rejection
    Allograft rejection0.86
    Asthma0.46
    Allograft Rejection0.86
    Intestinal immune network for IgA production0.41
    Autoimmune thyroid disease0.61
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57
    4Signaling by Interleukins
    Interleukin receptor SHC signaling0.67
    Interleukin-3, 5 and GM-CSF signaling0.59
    Interleukin-2 signaling0.67
    Signaling by Interleukins0.42
    5Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL5
        IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL5 (see all 26)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling

    3 Tocris Bioscience Pathways for IL5
        Akt Pathway
    Toll-like Receptor Pathway
    MAPK Pathway

    Selected BioSystems Pathways for IL5 (see all 8)
        Cytokines and Inflammatory Response
    Allograft Rejection
    IL-5 Signaling Pathway
    IL4-mediated signaling events
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes


    2 Reactome Pathways for IL5
        Interleukin receptor SHC signaling
    Interleukin-3, 5 and GM-CSF signaling


    Selected Kegg Pathways  (Kegg details for IL5) (see all 10):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Hematopoietic cell lineage
    T cell receptor signaling pathway
    Fc epsilon RI signaling pathway


    IL5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL5 (see all 15): 
              Fibrosis in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL5 (P051131, 3 ENSP000002314544) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSF2RBP329271, 3, ENSP000003840534EBI-2435811,EBI-1809771 I2D: score=1 STRING: ENSP00000384053
    IL5RAQ013441, 3, ENSP000002564524EBI-2435811,EBI-1759442 I2D: score=4 STRING: ENSP00000256452
    ETS1ENSP000003764364STRING: ENSP00000376436
    FOSENSP000003062454STRING: ENSP00000306245
    GATA3ENSP000003686324STRING: ENSP00000368632
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0008284positive regulation of cell proliferation ----
    GO:0019221cytokine-mediated signaling pathway IEA--
    GO:0030890positive regulation of B cell proliferation IEA--

    IL5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for IL5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
    PirfenidoneAntifibrotic agent; regulates cytokine levels in vivo[53179-13-8]
    GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines[6501-72-0]
    4-IPPInhibitor of macrophage migration inhibitory factor (MIF); suicide substrate[41270-96-6]
    ThalidomideTNF-alpha synthesis inhibitor[50-35-1]

    1 DrugBank Compound for IL5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pranlukast-- 103177-37-3targetantagonist12692940 15650315 11972613 16892782 10773010

    Selected Novoseek inferred chemical compound relationships for IL5 gene (see all 129)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mepolizumab 85.3 32 11496242 (4), 18410960 (2), 19426126 (1), 12870444 (1) (see all 20)
    rantes 82.4 224 10378529 (6), 8998072 (5), 8626989 (5), 19522185 (5) (see all 99)
    sch 55700 75.5 5 12649124 (2), 17364206 (1), 15577851 (1), 17088140 (1)
    allergens 74.2 34 16433854 (2), 19058497 (2), 9554118 (1), 9590218 (1) (see all 31)
    il 10 67.2 35 8310699 (2), 16943231 (2), 17928005 (2), 12191514 (2) (see all 28)
    ionomycin 66.3 37 1493921 (2), 7664804 (1), 9095665 (1), 9503684 (1) (see all 35)
    tarc 64.5 21 17165591 (4), 18395252 (3), 11956056 (2), 10050676 (1) (see all 15)
    sophoricoside 62.7 2 11106000 (2)
    histamine 61.6 125 7879707 (7), 7522070 (6), 7543541 (4), 1701820 (4) (see all 68)
    methacholine 59.2 35 18217313 (2), 9445301 (2), 16642575 (2), 9399955 (1) (see all 19)



    IL5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL5 gene: 
    NM_000879.2  

    Unigene Cluster for IL5:

    Interleukin 5 (colony-stimulating factor, eosinophil)
    Hs.2247  [show with all ESTs]
    Unigene Representative Sequence: DQ655974
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000231454(uc003kxe.1) ENST00000462418 ENST00000450655
    miRNA
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    Block miRNA regulation of human, mouse, rat IL5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IL5
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL5
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL5 (NM_000879)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL5
    Primer
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    OriGene qPCR primer pairs and template standards for IL5
    OriGene qSTAR qPCR primer pairs in human, mouse for IL5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL5
      QuantiTect SYBR Green Assays in human, mouse, rat IL5
      QuantiFast Probe-based Assays in human, mouse, rat IL5

    Additional mRNA sequence: 

    BC066279.1 BC066280.1 BC066281.1 BC066282.1 BC069137.1 DQ655971.2 DQ655974.2 X04688.1 
    X12705.1 

    2 DOTS entries:

    DT.100761466  DT.120846100 

    15 AceView cDNA sequences:

    NM_000879 CD559686 BC069137 X12705 CD559532 X04688 BC066281 BC066282 
    BC066279 BC066280 CD559535 CD559536 CD559534 CD559533 CD559608 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGATGCTTC
    IL5 Expression
    About this image


    IL5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Bone marrow-derived hematopoietic stem cells
    IL5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2247
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL5 (see all 15): 
              Fibrosis in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL5
    OriGene qSTAR qPCR primer pairs in human, mouse for IL5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL5
    QuantiTect SYBR Green Assays in human, mouse, rat IL5
    QuantiFast Probe-based Assays in human, mouse, rat IL5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL5 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il51 , 5 interleukin 51, 5 79.2(n)1
    71.79(a)1
      11 (31.99 cM)5
    161911  NM_010558.11  NP_034688.11 
     537207945 


    ENSEMBL Gene Tree for IL5 (if available)
    TreeFam Gene Tree for IL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL5 (see all 147)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs100654761,2
    C--132153435(+) CAGGGT/ACAGGT 1 -- ds50011Minor allele frequency- A:0.00EA 180
    rs727973451,2
    C--132153472(+) CAGAGA/GGGGTT 1 -- ds50010--------
    rs1453890731,2
    --132153490(+) TCCTCC/TCTATA 1 -- ds50010--------
    rs1480070371,2
    --132153555(+) TTACAA/GGTTCC 1 -- ds50010--------
    rs1417375671,2
    --132153582(+) CAGGGG/TACGCC 1 -- ds50010--------
    rs1115621071,2
    F--132153611(+) CTACAG/ATCAGT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1177887141,2
    F--132153698(+) GAAAAC/TCAGGT 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs1386555371,2
    C--132154131(+) GCAAAG/TTGTCA 1 -- ut310--------
    rs567537281,2
    C--132154180(+) TATACC/TGAAAA 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs20698181,2
    C,F,O,H--132154298(-) AACACC/AGAGTG 2 /T syn1 ese328Minor allele frequency- A:0.04NS EA NA MN WA 7306

    HapMap Linkage Disequilibrium report for IL5 (131877136 - 131892530 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IL5: --
    Human Gene Mutation Database (HGMD): IL5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL5
    DNA2.0 Custom Variant and Variant Library Synthesis for IL5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147850    OMIM disorders: --

    Selected diseases for IL5 (see all 225):    
    About MalaCards
    pulmonary eosinophilia    eosinophilia-myalgia syndrome    necatoriasis    eosinophilic meningitis
    eosinophilic gastritis    eosinophilic fasciitis    bagassosis    strongyloidiasis
    eosinophilic pneumonia    gastroenteritis    scleritis    eosinophilic gastroenteritis
    allergic asthma    fasciitis    paragonimiasis    filariasis
    familial eosinophilia    cough variant asthma    kimura disease    granulomatous angiitis

    10 diseases from the University of Copenhagen DISEASES database for IL5:
    Eosinophilia     Asthma     Allergic rhinitis     Eosinophilic esophagitis
    Hypersensitivity reaction type I disease     Dermatitis     Churg-Strauss syndrome     Kimura disease
    Filariasis     Eosinophilic gastroenteritis

    IL5 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for IL5 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    eosinophilia 91.9 508 9990366 (9), 10802841 (6), 17160990 (5), 2373861 (5) (see all 99)
    asthma 86.9 674 9493449 (9), 15805995 (7), 12915771 (6), 7499683 (5) (see all 99)
    asthma allergic 84.7 80 15805995 (4), 11842300 (3), 14521755 (2), 10069881 (2) (see all 56)
    hypereosinophilic syndrome 81.7 23 8608231 (2), 1753511 (1), 8906227 (1), 16418325 (1) (see all 20)
    inflammation 80.3 281 1401075 (3), 9284977 (2), 9751843 (2), 10939534 (2) (see all 99)
    dermatitis atopic 78.5 81 14581138 (4), 7523534 (3), 11886533 (3), 9164367 (3) (see all 56)
    nasal polyps 78.5 138 16929824 (6), 12916352 (5), 12563937 (4), 12768697 (4) (see all 54)
    allergic rhinitis 77.4 93 17438848 (5), 16722389 (4), 10852530 (4), 11884474 (3) (see all 47)
    allergy 76.4 69 7819742 (4), 8203203 (2), 17642139 (2), 9338549 (1) (see all 54)
    pulmonary eosinophilia 72.3 15 1475542 (1), 10030835 (1), 7613159 (1), 17996260 (1) (see all 13)

    Genetic Association Database (GAD): IL5
    Human Genome Epidemiology (HuGE) Navigator: IL5 (63 documents)

    Export disorders for IL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for IL5 gene, integrated from 10 sources (see all 2541):
    (articles sorted by number of sources associating them with IL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5). (PubMed id 3498940)1, 2, 3 Campbell H.D.... Young I.G. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    2. IL-5 and thromboxane A2 receptor gene polymorphisms are associated with decreased pulmonary function in Korean children with atopic asthma. (PubMed id 15805995)1, 4, 9 Hong S.J....Hong T.J. (J. Allergy Clin. Immunol. 2005)
    3. Analysis of polymorphisms in olive pollen allergy: IL13, IL4RA, IL5 and ADRB2 genes. (PubMed id 18849614)1, 4, 9 Llanes E....CA!rdaba B. (Int. Arch. Allergy Immunol. 2009)
    4. Heterogeneity of interleukin 5 genetic background in atopic dermatitis patients: significant difference between those with blood eosinophilia and normal eosinophil levels. (PubMed id 14581138)1, 4, 9 Yamamoto N....Uehara M. (J. Dermatol. Sci. 2003)
    5. Polymorphisms in eosinophil pathway genes, asthma and atopy. (PubMed id 17362254)1, 4, 9 Kabesch M....Nickel R. (Allergy 2007)
    6. Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum. (PubMed id 18056382)1, 4, 9 Ellis M.K....McManus D.P. (J. Immunol. 2007)
    7. IL-5 and IL-5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans. (PubMed id 17620072)1, 4, 9 Namkung J.H....Yang J.M. (Allergy 2007)
    8. Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma. (PubMed id 16449530)1, 4, 9 Lan Q....Chanock S. (Blood 2006)
    9. Risk of small-for-gestational age is associated with common anti-inflammatory cytokine polymorphisms. (PubMed id 15951665)1, 4, 9 Engel S.A....Chanock S.J. (Epidemiology 2005)
    10. Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. (PubMed id 15007355)1, 4, 9 Hoffjan S....Ober C. (J. Allergy Clin. Immunol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3567 HGNC: 6016 AceView: IL5 Ensembl:ENSG00000113525 euGenes: HUgn3567
    ECgene: IL5 Kegg: 3567 H-InvDB: IL5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IL5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL5 Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine mini-reviews: IL-5http://www.rndsystems.com/molecule_detail.aspx?m=1646
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_5
    SeattleSNPshttp://pga.gs.washington.edu/data/il5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL5 gene:
    Search GeneIP for patents involving IL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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