IL5 Gene
protein-coding GIFtS: 61
GCID: GC05M131881
|
|
interleukin 5 (colony-stimulating factor, eosinophil)
| |
Aliases
for IL5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interleukin 5 (Colony-Stimulating Factor, Eosinophil)1 2 | | Eosinophil Differentiation Factor2 3 | | IL-51 2 3 | | B-Cell Differentiation Factor I2 3 | | TRF1 2 3 | | T-Cell Replacing Factor2 3 | | EDF1 2 | | Interleukin-51 |
Export aliases for IL5 gene to outside databasesPrevious GC identifers: GC05M131399 GC05M132324 GC05M131907 GC05M131953 GC05M131905 GC05M127069 |
Summaries
for IL5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IL5:
The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells andeosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevatedproduction of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of thiscytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colonystimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), andCSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulatedcoordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: IL5_HUMAN, P05113Function: Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells
 summary
for IL5: Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.
Gene Wiki entry for IL5 (Interleukin 5)
|
Genomic Views
for IL5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IL5 gene promoter:
GR GATA-3 GR-beta POU3F2 (N-Oct-5b) GR-alpha C/EBPalpha GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IL5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q23-q31IL5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M131881: view genomic region
(about GC identifiers)
Start:
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131,877,136 bp from pter |
End:
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131,892,530 bp from pter |
Size:
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15,395 bases |
Orientation:
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minus strand |
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Proteins
for IL5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IL5_HUMAN, P05113 (See
protein sequence)Recommended Name: Interleukin-5 precursor Size: 134 amino acids; 15238 Da
Subunit: Homodimer; disulfide-linked
Subcellular location: Secreted
3 PDB 3D structures from  and Proteopedia  for IL5:1HUL (3D)
3QT2 (3D)
3VA2 (3D)
Secondary accessions: Q13840Explore the universe of human proteins at neXtProt for IL5: NX_P05113
IL5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000870.1
ENSEMBL proteins: ENSP00000231454 ENSP00000409825 Reactome Protein details: P05113
Human Recombinant Protein Products for IL5:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
IL5 for ontologies About GeneDecksing
IL5 Antibody Products:
Assay Products for IL5: |
Protein
Domains /
Families
for IL5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IL5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P05113ProtoNet protein and cluster: P05113 1 Blocks protein family: IPB000186 Interleukin-5 signature
UniProtKB/Swiss-Prot: IL5_HUMAN, P05113Similarity: Belongs to the IL-5 family |
Function
for IL5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: IL5_HUMAN, P05113Function: Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells Genatlas biochemistry entry for IL5:interleukin 5,colony-stimulating factor (eosinophil),homodimerizing,inducing terminal differentiation of B cells toimmunoglobulin secreting cells
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
IL5 for ontologies About GeneDecksing
Phenotypes:
11 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Il5):
IL5 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for IL5: Il5tm1Kopf Il5tm1Anjm Il5tm3Anjm Il5tm2Anjm
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IL5 (NM_000879) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL5 |
|
Pathways & Interactions
for IL5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/26 super-pathways (see all 26) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | PEDF Induced Signaling | | | 2 | Interleukin receptor SHC signaling | | | 3 | TGF-Beta Pathway | | | 4 | Allograft rejection | | | 5 | Akt Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for IL5
1  R&D Systems Pathway for IL5
5/26 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL5 (see all 26)
3 Tocris Bioscience Pathways for IL5
5/7  BioSystems Pathways for IL5 (see all 7)
5/9 
Reactome Pathways for IL5 (see all 9)
5/9 
Kegg Pathways (Kegg details for IL5) (see all 9):
IL5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/29 Interacting proteins for IL5 (P051131, 3 ENSP000002314544) via UniProtKB, MINT, STRING, and/or I2D (see all 29)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006954 | inflammatory response |
IEA | -- | | GO:0006955 | immune response |
IEA | -- | | GO:0008284 | positive regulation of cell proliferation |
-- | -- | | GO:0019221 | cytokine-mediated signaling pathway |
IEA | -- | | GO:0030890 | positive regulation of B cell proliferation |
IEA | -- |
IL5 for ontologies About GeneDecksing
|
Drugs & Compounds
for IL5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
IL5 for compounds About GeneDecksing
Compounds for IL5 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Lyn peptide inhibitor | Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable | [222018-18-0] | | YM 90709 | Interleukin-5 receptor antagonist | [163769-88-8] |
1 DrugBank Compound for IL5 About this table
10/129 Novoseek chemical compound relationships for IL5 gene (see all 129) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| mepolizumab |
85.3 |
32 |
11496242 (4), 18410960 (2), 19426126 (1), 12870444 (1) (see all 20) |
| rantes |
82.4 |
224 |
10378529 (6), 8998072 (5), 8626989 (5), 19522185 (5) (see all 99) |
| sch 55700 |
75.5 |
5 |
12649124 (2), 17364206 (1), 15577851 (1), 17088140 (1) |
| allergens |
74.2 |
34 |
16433854 (2), 19058497 (2), 9554118 (1), 9590218 (1) (see all 31) |
| il 10 |
67.2 |
35 |
8310699 (2), 16943231 (2), 17928005 (2), 12191514 (2) (see all 28) |
| ionomycin |
66.3 |
37 |
1493921 (2), 7664804 (1), 9095665 (1), 9503684 (1) (see all 35) |
| tarc |
64.5 |
21 |
17165591 (4), 18395252 (3), 11956056 (2), 10050676 (1) (see all 15) |
| sophoricoside |
62.7 |
2 |
11106000 (2) |
| histamine |
61.6 |
125 |
7879707 (7), 7522070 (6), 7543541 (4), 1701820 (4) (see all 68) |
| methacholine |
59.2 |
35 |
18217313 (2), 9445301 (2), 16642575 (2), 9399955 (1) (see all 19) |
Search CenterWatch for drugs/clinical trials and news about IL5
|
Transcripts
for IL5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IL5 gene: NM_000879.2 Unigene Cluster for IL5: Interleukin 5 (colony-stimulating factor, eosinophil) Hs.2247 [show with all ESTs]Unigene Representative Sequence: DQ6559743 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000231454(uc003kxe.1) ENST00000462418 ENST00000450655
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IL5 (NM_000879) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL5 |
Additional cDNA sequence: BC066279.1 BC066280.1 BC066281.1 BC066282.1 BC069137.1 DQ655971.2 DQ655974.2 X04688.1 X12705.1 2 DOTS entries: DT.100761466 DT.120846100 15 AceView cDNA sequences: NM_000879 CD559686 BC069137 BC066282 BC066280 BC066281 CD559532 BC066279 X04688 X12705 CD559535 CD559534 CD559536 CD559533 CD559608
GeneLoc Exon Structure
|
Expression
for IL5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IL5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGATGCTTC
About this image
See IL5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL5
SOURCE GeneReport for Unigene cluster: Hs.2247
SABiosciences Expression via Pathway-Focused PCR Arrays including IL5 (see all 15):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL5 |
Orthologs
for IL5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for IL5 gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for IL5 (if available)
TreeFam Gene Tree for IL5 (if available) |
Paralogs
for IL5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IL5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IL5 (131877136 - 131892530 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL5: --
Human Gene Mutation Database (HGMD): IL5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL5 |
|
Disorders
/ Diseases
for IL5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IL5 for disorders About GeneDecksing
OMIM gene information: 147850
OMIM disorders: --
20/242  diseases for IL5 (see all 242): About MalaCardshypereosinophilic syndrome churg-strauss syndrome eosinophilia-myalgia syndrome asthma
cough variant asthma eosinophilic fasciitis diffuse large b-cell lymphoma ocular cicatricial pemphigoid
cicatricial pemphigoid hypersensitivity reaction type ii disease eosinophilic pneumonia eosinophilic gastroenteritis
granulomatous angiitis severe combined immunodeficiency intrinsic asthma allergic bronchopulmonary aspergillosis
patent ductus arteriosus otitis media eosinophilia mycosis fungoides
10 diseases from the University of Copenhagen DISEASES database for IL5:Eosinophilia Asthma Allergic rhinitis Eosinophilic esophagitis
Hypersensitivity reaction type I disease Dermatitis Churg-Strauss syndrome Kimura disease
Filariasis Eosinophilic gastroenteritis 10/97 Novoseek disease relationships for IL5 gene (see all 97) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| eosinophilia |
91.9 |
508 |
9990366 (9), 10802841 (6), 17160990 (5), 2373861 (5) (see all 99) |
| asthma |
86.9 |
674 |
9493449 (9), 15805995 (7), 12915771 (6), 7499683 (5) (see all 99) |
| asthma allergic |
84.7 |
80 |
15805995 (4), 11842300 (3), 14521755 (2), 10069881 (2) (see all 56) |
| hypereosinophilic syndrome |
81.7 |
23 |
8608231 (2), 1753511 (1), 8906227 (1), 16418325 (1) (see all 20) |
| inflammation |
80.3 |
281 |
1401075 (3), 9284977 (2), 9751843 (2), 10939534 (2) (see all 99) |
| dermatitis atopic |
78.5 |
81 |
14581138 (4), 7523534 (3), 11886533 (3), 9164367 (3) (see all 56) |
| nasal polyps |
78.5 |
138 |
16929824 (6), 12916352 (5), 12563937 (4), 12768697 (4) (see all 54) |
| allergic rhinitis |
77.4 |
93 |
17438848 (5), 16722389 (4), 10852530 (4), 11884474 (3) (see all 47) |
| allergy |
76.4 |
69 |
7819742 (4), 8203203 (2), 17642139 (2), 9338549 (1) (see all 54) |
| pulmonary eosinophilia |
72.3 |
15 |
1475542 (1), 10030835 (1), 7613159 (1), 17996260 (1) (see all 13) |
Genetic Association Database (GAD): IL5
Human Genome Epidemiology (HuGE) Navigator: IL5 (63 documents)
Export disorders for IL5 gene to outside databases
|
Publications
for IL5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IL5 gene, integrated from 9 sources (see all 2527):
(articles sorted by number of sources associating them with IL5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5). (PubMed id 3498940)1, 2, 3 Campbell H.D.... Young I.G. (1987)
- IL-5 and thromboxane A2 receptor gene polymorphisms are associated with decreased pulmonary function in Korean children with atopic asthma. (PubMed id 15805995)1, 4, 9 Hong S.J....Hong T.J. (2005)
- Heterogeneity of interleukin 5 genetic background in atopic dermatitis patients: significant difference between those with blood eosinophilia and normal eosinophil levels. (PubMed id 14581138)1, 4, 9 Yamamoto N....Uehara M. (2003)
- Risk of small-for-gestational age is associated with common anti-inflammatory cytokine polymorphisms. (PubMed id 15951665)1, 4, 9 Engel S.A....Chanock S.J. (2005)
- Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. (PubMed id 15007355)1, 4, 9 Hoffjan S....Ober C. (2004)
- Chromosome 5q candidate genes in coeliac disease: genetic variation at IL4, IL5, IL9, IL13, IL17B and NR3C1. (PubMed id 15713213)1, 4 Ryan A.W....McManus R. (2005)
- The role of cytokine gene polymorphisms in determining disease susceptibility and phenotype in inflammatory bowel disease. (PubMed id 15842590)1, 4 Cantor M.J....Bernstein C.N. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A novel dimer configuration revealed by the crystal structure at 2.4- A resolution of human interleukin-5. (PubMed id 8483502)1, 2 Milburn M.V.... Wells T.N.C. (1993)
- Human interleukin-5 expressed in Escherichia coli: assignment of the disulfide bridges of the purified unglycosylated protein. (PubMed id 2037074)1, 2 Proudfoot A.E.I.... Wingfield P.T. (1991)
|
External Searches for IL5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IL5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IL5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IL5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IL5 | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for IL5 | Genetics and Cytogenetics in Oncology and Haematology | | R&D Systems' cytokine mini-reviews: IL-5 | http://www.rndsystems.com/molecule_detail.aspx?m=1646 | | Wikipedia | http://en.wikipedia.org/wiki/Interleukin_5 | | SeattleSNPs | http://pga.gs.washington.edu/data/il5/ |
|
| | |
About This Section
| Patent Information for IL5 gene:
Search GeneIP for patents involving IL5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IL5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IL5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL5 | | | OriGene Protein Over-expression Lysate for IL5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IL5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IL5 | | OriGene Custom Protein Services for IL5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL5 |
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| | | | Tocris compounds for IL5 |
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 | | | IL5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibody for IL5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL5 |
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