Aliases for IL4R Gene
Aliases for IL4R Gene
External Ids for IL4R Gene
- HGNC: 6015
- Entrez Gene: 3566
- Ensembl: ENSG00000077238
- OMIM: 147781
- UniProtKB: P24394
Previous GeneCards Identifiers for IL4R Gene
- GC16P026753
- GC16P027424
- GC16P027252
- GC16P027317
- GC16P027291
- GC16P027248
- GC16P025413
Summaries for IL4R Gene
-
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
GeneCards Summary for IL4R Gene
IL4R (Interleukin 4 Receptor) is a Protein Coding gene. Diseases associated with IL4R include Atopy and Hiv-1. Among its related pathways are PEDF Induced Signaling and Th2 Differentiation Pathway. GO annotations related to this gene include signal transducer activity, downstream of receptor and interleukin-4 receptor activity.
UniProtKB/Swiss-Prot for IL4R Gene
-
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
-
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL4R Gene
Genomics for IL4R Gene
Regulatory Elements for IL4R Gene
Enhancers for IL4R Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around IL4R on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the IL4R gene promoter:
Regulatory Element Products
Genomic Location for IL4R Gene
- Chromosome:
- 16
- Start:
- 27,313,668 bp from pter
- End:
- 27,364,778 bp from pter
- Size:
- 51,111 bases
- Orientation:
- Plus strand
Genomic View for IL4R Gene
Genes around IL4R on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p12.1 by Ensembl
- 16p12.1 by Entrez Gene
- 16p12.1 by HGNC
IL4R Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL4R Gene
Proteins for IL4R Gene
-
Protein details for IL4R Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P24394-IL4RA_HUMAN
- Recommended name:
- Interleukin-4 receptor subunit alpha
- Protein Accession:
- P24394
- B4E076
- B9EKU8
- H3BSY5
- Q96P01
- Q9H181
- Q9H182
- Q9H183
- Q9H184
- Q9H185
- Q9H186
- Q9H187
- Q9H188
Protein attributes for IL4R Gene
- Size:
- 825 amino acids
- Molecular mass:
- 89658 Da
- Quaternary structure:
-
- The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor (PubMed:7775445, PubMed:8804422). Interacts with PIK3C3 (By similarity). Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (PubMed:11714803). Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling (By similarity). Interacts with JAK3 (PubMed:7538655). Interacts with CLM1 (By similarity).
Three dimensional structures from OCA and Proteopedia for IL4R Gene
Protein Expression for IL4R Gene
Post-translational modifications for IL4R Gene
- On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.
- The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.
- Glycosylation at posLast=5353, isoforms=2, 398, posLast=128128, posLast=134134, posLast=176176, and isoforms=2, 3209
- Modification sites at PhosphoSitePlus
Other Protein References for IL4R Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for IL4R
- R&D Systems Antibodies for IL4R (IL-4 R alpha)
-
Custom Antibody ServicesOriGene Antibodies for IL4R
- Novus Biologicals Antibodies for IL4R
-
Abcam antibodies for IL4R
- Invitrogen Antibodies for IL4R
- antibodies-online Antibodies for IL4R: See all 115
- GeneTex IL4R antibody for IL4R
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL4R
Protein Products
- R&D Systems Proteins and Enzymes for IL4R (IL-4 R alpha)
-
OriGene Purified Proteins for IL4R
- Search Origene for MassSpec and Protein Over-expression Lysates for IL4R
- Origene Custom Protein Services for IL4R
- Sino Biological Recombinant Proteins for IL4R
- Sino Biological Cell Lysates for IL4R
- antibodies-online Proteins for IL4R: See all 29
- Search antibodies-online for peptides
- GeneTex Proteins for IL4R
-
ProSci Proteins for IL4R
-
Abcam proteins for IL4R
Assay Products
- R&D Systems Luminex Assays and other biochemical assays for IL4R (IL-4 R alpha)
- antibodies-online Kits for IL4R: See all 22
No data available for DME Specific Peptides for IL4R Gene
Domains & Families for IL4R Gene
Gene Families for IL4R Gene
- HGNC:
- IUPHAR :
Protein Domains for IL4R Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for IL4R Gene
Graphical View of Domain Structure for InterPro Entry
P24394UniProtKB/Swiss-Prot:
IL4RA_HUMAN :- The extracellular domain represents the IL4 binding protein (IL4BP).
- Belongs to the type I cytokine receptor family. Type 4 subfamily.
- Domain:
-
- The extracellular domain represents the IL4 binding protein (IL4BP).
- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- The box 1 motif is required for JAK interaction and/or activation.
- Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
- Family:
-
- Belongs to the type I cytokine receptor family. Type 4 subfamily.
Function for IL4R Gene
Molecular function for IL4R Gene
- GENATLAS Biochemistry:
- interleukin 4,receptor (see IL2RG),expressed on T-cell,with a polymorphism associated with increased signaling and susceptibility to atopy asthma and hyper IgE syndrome
- UniProtKB/Swiss-Prot Function:
- Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
- UniProtKB/Swiss-Prot Function:
- Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004896 | cytokine receptor activity | IEA | -- |
| GO:0004913 | interleukin-4 receptor activity | TAS | 2307934 |
| GO:0005057 | signal transducer activity, downstream of receptor | TAS | 2307934 |
| GO:0005515 | protein binding | IPI | 8266078 |
Phenotypes for IL4R Gene
- MGI mutant phenotypes for IL4R:
-
inferred from 6 alleles
- mortality/aging
- cellular phenotype
- growth/size/body region phenotype
- immune system phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- integument phenotype
- hematopoietic system phenotype
- liver/biliary system phenotype
- GenomeRNAi human phenotypes for IL4R:
-
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased viability ratio
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Effect on mitosis
- Decreased IL-8 secretion
- Decreased shRNA abundance (Z-score < -2)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
Animal Model Products
-
Taconic Biosciences Mouse Models for IL4R
-
ViGene Biosciences lentiviral particle packaged cDNA for IL4R gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IL4R gene
- Search ViGene Biosciences for IL4R
CRISPR Products
-
OriGene CRISPR knockouts for IL4R
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL4R
- GenScript: Design CRISPR guide RNA sequences for IL4R
miRNA for IL4R Gene
- miRTarBase miRNAs that target IL4R
miRNA Products
- Search ViGene Biosciences for IL4R
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for IL4R
- Browse OriGene Inhibitory RNA Products For IL4R
-
ViGene Biosciences ready-to-package AAV shRNAs for IL4R gene
Clone Products
- Sino Biological Human cDNA Clone for IL4R
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for IL4R (IL-4 R alpha)
Cell Line Products
-
Horizon Cell Lines for IL4R
-
ViGene Biosciences adenoviral particle packaged cDNA for IL4R gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IL4R gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IL4R gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL4R Gene
Localization for IL4R Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL4R Gene
- Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 2 |
| peroxisome | 1 |
| nucleus | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 2307934 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for IL4R Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.47
|
|
| 2 | TGF-Beta Pathway |
.60
|
.57
.51
|
| 3 | Th17 cell differentiation | ||
| 4 | Akt Signaling |
.60
.60
|
|
| 5 | IL-2 Pathway |
.34
|
|
Pathways by source for IL4R Gene
2 Sino Biological pathways for IL4R Gene
3 BioSystems pathways for IL4R Gene
4 Reactome pathways for IL4R Gene
1 GeneGo (Thomson Reuters) pathway for IL4R Gene
6 R&D Systems pathways for IL4R Gene
- B Cell Development Pathways
- IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types
- IL-4 Signaling Pathways
- IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types
- IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types
16 Qiagen pathways for IL4R Gene
Interacting Proteins for IL4R Gene
Selected Interacting proteins:
P24394-IL4RA_HUMAN
ENSP00000170630
for IL4R Gene via
MINT
STRING
UniProtKB
IID
SIGNOR curated interactions for IL4R Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002532 | production of molecular mediator involved in inflammatory response | IEA | -- |
| GO:0002639 | positive regulation of immunoglobulin production | IEA | -- |
| GO:0006955 | immune response | TAS | 2307934 |
| GO:0007165 | signal transduction | TAS | 2307934 |
| GO:0016064 | immunoglobulin mediated immune response | IEA | -- |
Drugs & Compounds for IL4R Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for IL4R Gene
mRNA/cDNA for IL4R Gene
- (18) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (231) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IL4R Gene
- Interleukin 4 receptor:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for IL4R
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL4R
- GenScript: Design CRISPR guide RNA sequences for IL4R
miRNA Products
- Search ViGene Biosciences for IL4R
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for IL4R
- Browse OriGene Inhibitory RNA Products For IL4R
-
ViGene Biosciences ready-to-package AAV shRNAs for IL4R gene
Clone Products
- Sino Biological Human cDNA Clone for IL4R
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for IL4R (IL-4 R alpha)
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - |
Expression for IL4R Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
- Hematopoietic Bone Marrow
- Fibroblasts (Uncategorized)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Thymus (Hematopoietic System)
- Eye (Sensory Organs)
-
Spleen (Hematopoietic System)
-
Tonsil (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for IL4R Gene
This gene is overexpressed in Whole Blood (x10.5).
This gene is overexpressed in Blymphocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL4R Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of IL4R Gene:
IL4RSOURCE GeneReport for Unigene cluster for IL4R Gene:
Hs.513457mRNA Expression by UniProt/SwissProt for IL4R Gene:
P24394-IL4RA_HUMAN
Tissue specificity:
Isoform 1 and isoform 2 are highly expressed in activated T-cells.
Evidence on tissue expression from TISSUES for IL4R Gene
- Blood(4.5)
- Lymph node(2.5)
- Bone marrow(2.3)
- Intestine(2.3)
- Lung(2.3)
- Spleen(2.3)
Primer Products
-
OriGene qPCR primer pairs for IL4R
-
OriGene qPCR primer pairs and template standards for IL4R
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IL4R Gene
Orthologs for IL4R Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IL4R 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | IL4R 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | IL4R 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Il4r 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Il4ra 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | IL4R 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | IL4R 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | IL4RA 35 |
|
OneToOne |
- Species where no ortholog for IL4R was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for IL4R Gene
No data available for Paralogs for IL4R Gene
Variants for IL4R Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for IL4R Gene
- IL4RA_HUMAN-P24394
- Allelic variants in IL4RA are associated with a susceptibility to atopy, an immunological condition that can lead to clinical symptoms such as allergic rhinitis, sinusitis, asthma and eczema.
- IL4RA_HUMAN-P24394
- Allelic variants in IL4RA are associated with cedar pollen sensitization. Individuals develop Japanese cedar pollinosis with increased exposure to cedar pollen. Japanese cedar pollinosis is a type I allergic disease with ocular and nasal symptoms that develop paroxysmally on contact with Japanese cedar pollen. These symptoms, which occur seasonally each year, are typical features of allergic rhinitis, such as sneezing, excessive nasal secretion, nasal congestion, and conjunctival itching.
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1805010 | Pathogenic | 27,344,882(+) | CGTGT(A/C/G/T)TCCCT | reference, synonymous-codon, missense, utr-variant-5-prime | |
| rs1801275 | other | 27,363,079(+) | CTATC(A/G)GGAGT | downstream-variant-500B, reference, missense | |
| rs1805015 | other | 27,362,859(+) | GCAAC(C/T)CCCTG | downstream-variant-500B, reference, missense | |
| rs1000044741 | -- | 27,354,016(+) | CTTCT(G/T)GAAAG | intron-variant, upstream-variant-2KB | |
| rs1000058651 | -- | 27,356,886(+) | AAAGG(C/T)TGAGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1333n106 | CNV | deletion | 24896259 |
| dgv4962n54 | CNV | loss | 21841781 |
| dgv4963n54 | CNV | loss | 21841781 |
| dgv811e212 | CNV | loss | 25503493 |
| dgv812e212 | CNV | loss | 25503493 |
| esv24900 | CNV | loss | 19812545 |
| esv2664327 | CNV | deletion | 23128226 |
| esv2762344 | CNV | loss | 21179565 |
| esv3553287 | CNV | deletion | 23714750 |
| esv3638324 | CNV | loss | 21293372 |
| nsv1059454 | CNV | gain | 25217958 |
| nsv516053 | CNV | gain+loss | 19592680 |
| nsv571721 | CNV | loss | 21841781 |
| nsv833179 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
14.76;
96.66% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for IL4R Gene
Disorders for IL4R Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| atopy |
|
|
| hiv-1 |
|
|
| allergic rhinitis |
|
|
| beta-lactam allergy |
|
|
| rhinitis |
|
|
Search IL4R in MalaCards
View complete list of genes associated with diseases
Relevant External Links for IL4R
No data available for UniProtKB/Swiss-Prot and Genatlas for IL4R Gene
Publications for IL4R Gene
- The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. (PMID: 9392697) Hershey G.K.K. … Chatila T.A. (N. Engl. J. Med. 1997) 3 4 22 46 64
- Analysis of polymorphisms in olive pollen allergy: IL13, IL4RA, IL5 and ADRB2 genes. (PMID: 18849614) Llanes E. … CA!rdaba B. (Int. Arch. Allergy Immunol. 2009) 3 22 46 64
- Genetic variants in immunoregulatory genes and risk for childhood lymphomas. (PMID: 19508433) Andrie E. … Petridou E.T. (Eur. J. Haematol. 2009) 3 22 46 64
- Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial. (PMID: 19515749) Schoof N. … Kube D. (Ann. Oncol. 2009) 3 22 46 64
- Interleukin promoter polymorphisms and prognosis in colorectal cancer. (PMID: 18448485) Wilkening S. … FAPrsti A. (Carcinogenesis 2008) 3 22 46 64
Products for IL4R Gene
- R&D Systems Antibodies for IL4R (IL-4 R alpha)
- R&D Systems Proteins and Enzymes for IL4R (IL-4 R alpha)
- R&D Systems Luminex Assays and other biochemical assays for IL4R (IL-4 R alpha)
- R&D Systems cDNA Clones for IL4R (IL-4 R alpha)
- Browse Primary Antibodies
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for IL4R
- Custom Assay Services
- OriGene Purified Proteins for IL4R
- Search Origene for MassSpec and Protein Over-expression Lysates for IL4R
- Origene Custom Protein Services for IL4R
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for IL4R
- Browse OriGene Inhibitory RNA Products For IL4R
- OriGene qPCR primer pairs and template standards for IL4R
- OriGene qPCR primer pairs for IL4R
- OriGene CRISPR knockouts for IL4R
- OriGene ORF clones in human for IL4R
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for IL4R in any vector
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- GenScript: Design CRISPR guide RNA sequences for IL4R
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for IL4R
- Sino Biological Human cDNA Clone for IL4R
- Sino Biological Recombinant Proteins for IL4R
- Sino Biological Cell Lysates for IL4R
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for IL4R
- Novus Biologicals proteins and lysates for IL4R
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for IL4R
- Abcam proteins for IL4R
- Search for Assays for IL4R at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Taconic Biosciences Mouse Models for IL4R
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for IL4R: See all 115
- antibodies-online Kits for IL4R: See all 22
- antibodies-online Proteins for IL4R: See all 29
- Search antibodies-online for peptides
- GeneTex IL4R antibody for IL4R
- GeneTex Proteins for IL4R
- ViGene Biosciences adenoviral particle packaged cDNA for IL4R gene
- ViGene Biosciences lentiviral particle packaged cDNA for IL4R gene
- ViGene Biosciences ready-to-package AAV shRNAs for IL4R gene
- Search ViGene Biosciences for IL4R
- Santa Cruz Biotechnology (SCBT) Antibodies for IL4R
- Search Santa Cruz Biotechnology (SCBT) for IL4R siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IL4R
- Search for IL4R Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for IL4R
- Horizon Cell Lines for IL4R
- Cyagen custom Knockout/knockin (KOKI) mouse models for IL4R
- VectorBuilder custom plasmid, inducible vectors for IL4R
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL4R
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for IL4R Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer