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Aliases for IL4I1 Gene

Aliases for IL4I1 Gene

  • Interleukin 4 Induced 1 2 3
  • IL4-Induced Protein 1 3 4
  • FIG1 3 4
  • LAAO 3 4
  • LAO 3 4
  • Interleukin-4-Induced Protein 1 4
  • Interleukin Four Induced 1 3
  • Fig-1 Protein 3
  • Protein Fig-1 4
  • EC 1.4.3.2 4
  • HFIG1 4

External Ids for IL4I1 Gene

Previous GeneCards Identifiers for IL4I1 Gene

  • GC19U990319
  • GC19M050741
  • GC19M055069
  • GC19M055065
  • GC19M055085
  • GC19M055070
  • GC19M055090
  • GC19M055092
  • GC19M055094
  • GC19M055096
  • GC19M055098
  • GC19M055099
  • GC19M055100
  • GC19M055106
  • GC19M055108
  • GC19M050392
  • GC19M046769

Summaries for IL4I1 Gene

Entrez Gene Summary for IL4I1 Gene

  • This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The expression of this gene can be induced by interleukin 4 in B cells, however, expression of transcripts containing the first two exons of the upstream gene is found in other cell types. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for IL4I1 Gene

IL4I1 (Interleukin 4 Induced 1) is a Protein Coding gene. Diseases associated with IL4I1 include posterior myocardial infarction and tricuspid valve insufficiency. Among its related pathways are Metabolism and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include oxidoreductase activity and L-amino-acid oxidase activity.

UniProtKB/Swiss-Prot for IL4I1 Gene

  • Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL4I1 Gene

Genomics for IL4I1 Gene

Regulatory Elements for IL4I1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IL4I1 Gene

Chromosome:
19
Start:
49,889,654 bp from pter
End:
49,929,539 bp from pter
Size:
39,886 bases
Orientation:
Minus strand

Genomic View for IL4I1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL4I1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL4I1 Gene

Proteins for IL4I1 Gene

  • Protein details for IL4I1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RQ9-OXLA_HUMAN
    Recommended name:
    L-amino-acid oxidase
    Protein Accession:
    Q96RQ9
    Secondary Accessions:
    • Q1WMJ3
    • Q4GZN1
    • Q4GZN2
    • Q6P2Q3
    • Q8TEM5
    • Q96RQ8

    Protein attributes for IL4I1 Gene

    Size:
    567 amino acids
    Molecular mass:
    62881 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84923.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI54291.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI54292.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI54293.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL4I1 Gene

    Alternative splice isoforms for IL4I1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL4I1 Gene

Proteomics data for IL4I1 Gene at MOPED

Post-translational modifications for IL4I1 Gene

  • Glycosylation at Asn 54, Asn 134, Asn 220, and Asn 559
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for IL4I1 Gene

Domains & Families for IL4I1 Gene

Protein Domains for IL4I1 Gene

Suggested Antigen Peptide Sequences for IL4I1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96RQ9

UniProtKB/Swiss-Prot:

OXLA_HUMAN :
  • Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
Family:
  • Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
genes like me logo Genes that share domains with IL4I1: view

No data available for Gene Families for IL4I1 Gene

Function for IL4I1 Gene

Molecular function for IL4I1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
An L-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2)
UniProtKB/Swiss-Prot Function:
Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity).
UniProtKB/Swiss-Prot Induction:
By IL4/interleukin-4

Enzyme Numbers (IUBMB) for IL4I1 Gene

Gene Ontology (GO) - Molecular Function for IL4I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001716 L-amino-acid oxidase activity EXP --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with IL4I1: view
genes like me logo Genes that share phenotypes with IL4I1: view

Animal Models for IL4I1 Gene

MGI Knock Outs for IL4I1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL4I1

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for IL4I1 Gene

Localization for IL4I1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL4I1 Gene

Isoform 1: Lysosome.
Isoform 2: Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL4I1 Gene COMPARTMENTS Subcellular localization image for IL4I1 gene
Compartment Confidence
extracellular 4
lysosome 3
vacuole 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IL4I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005764 lysosome IEA --
genes like me logo Genes that share ontologies with IL4I1: view

Pathways & Interactions for IL4I1 Gene

genes like me logo Genes that share pathways with IL4I1: view

Interacting Proteins for IL4I1 Gene

Gene Ontology (GO) - Biological Process for IL4I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006559 L-phenylalanine catabolic process TAS --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with IL4I1: view

No data available for SIGNOR curated interactions for IL4I1 Gene

Drugs & Compounds for IL4I1 Gene

(20) Drugs for IL4I1 Gene - From: HMDB, DrugBank, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma Target 0
L-Aspartic acid Approved Nutra 0
L-Isoleucine Approved Nutra 0
L-Methionine Approved Nutra 0
L-Phenylalanine Approved Nutra 0

(22) Additional Compounds for IL4I1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
2-Oxo-4-methylthiobutanoic acid
  • 2-Keto-4-methylthiobutyrate
  • 2-Keto-4-methylthiobutyric acid
  • 2-Ketomethiobutyrate
  • 2-Oxo-4-methylthiobutanoate
  • 2-Oxo-4-methylthiobutanoic acid
583-92-6
3-Methyl-2-oxovaleric acid
  • (3R)-3-Methyl-2-oxopentanoate
  • (3R)-3-Methyl-2-oxopentanoic acid
  • (R)-3-methyl-2-oxopentanoate
  • (R)-3-methyl-2-oxopentanoic acid
  • (S)-3-methyl-2-oxopentanoate
1460-34-0
4-Hydroxyphenylpyruvic acid
  • (p-hydroxyphenyl)-Pyruvate
  • (p-hydroxyphenyl)-Pyruvic acid
  • (p-Hydroxyphenyl)pyruvate
  • (p-Hydroxyphenyl)pyruvic acid
  • 3-(4-Hydroxyphenyl)-2-oxo-propanoate
156-39-8
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
genes like me logo Genes that share compounds with IL4I1: view

Transcripts for IL4I1 Gene

Unigene Clusters for IL4I1 Gene

Interleukin 4 induced 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL4I1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL4I1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12
SP1:
SP2:
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: - -
SP7: -
SP8:
SP9:

Relevant External Links for IL4I1 Gene

GeneLoc Exon Structure for
IL4I1
ECgene alternative splicing isoforms for
IL4I1

Expression for IL4I1 Gene

mRNA expression in normal human tissues for IL4I1 Gene

mRNA differential expression in normal tissues according to GTEx for IL4I1 Gene

This gene is overexpressed in Testis (x8.3).

Protein differential expression in normal tissues from HIPED for IL4I1 Gene

This gene is overexpressed in Lung (20.7), Lymph node (13.2), Peripheral blood mononuclear cells (9.9), and Testis (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL4I1 Gene



SOURCE GeneReport for Unigene cluster for IL4I1 Gene Hs.741750

mRNA Expression by UniProt/SwissProt for IL4I1 Gene

Q96RQ9-OXLA_HUMAN
Tissue specificity: Isoform 1 is primarily found in immune tissues.
genes like me logo Genes that share expression patterns with IL4I1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for IL4I1 Gene

Orthologs for IL4I1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IL4I1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia IL4I1 35
  • 81.79 (n)
  • 76.09 (a)
IL4I1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il4i1 35
  • 79.23 (n)
  • 79.96 (a)
Il4i1 16
Il4i1 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL4I1 35
  • 98.51 (n)
  • 98.03 (a)
IL4I1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100360621 35
  • 77.97 (n)
  • 77.33 (a)
cow
(Bos Taurus)
Mammalia IL4I1 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL4I1 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL4I1 36
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL4I1 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493881 35
  • 49.15 (n)
  • 45.34 (a)
LOC394934 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1078 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-40g16.6 35
  • 49.46 (n)
  • 43.32 (a)
IL4I1 36
  • 41 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11911 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2768 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01066 35
  • 45.52 (n)
  • 30.66 (a)
Species with no ortholog for IL4I1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL4I1 Gene

ENSEMBL:
Gene Tree for IL4I1 (if available)
TreeFam:
Gene Tree for IL4I1 (if available)

Paralogs for IL4I1 Gene

No data available for Paralogs for IL4I1 Gene

Variants for IL4I1 Gene

Sequence variations from dbSNP and Humsavar for IL4I1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1290748 -- 49,904,858(+) gcgcc(C/T)gccac intron-variant
rs1290751 -- 49,895,682(+) ACTAC(A/G)GGGAA intron-variant
rs1290752 -- 49,897,779(+) AGGGG(C/G)TCCGT intron-variant, upstream-variant-2KB
rs1290753 -- 49,898,404(+) gaggc(C/T)gaggt intron-variant, upstream-variant-2KB
rs1290754 -- 49,901,682(-) ACCAT(A/C)AAGGC reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for IL4I1 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv912269 CNV Loss 21882294
dgv53n68 CNV Loss 17160897
dgv3974n71 CNV Loss 21882294
dgv54n68 CNV Loss 17160897
nsv524068 CNV Loss 19592680
nsv2519 CNV Loss 18451855
esv996372 CNV Deletion 20482838
nsv458720 CNV Gain 19166990
nsv7309 OTHER Inversion 18451855

Variation tolerance for IL4I1 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL4I1 Gene

HapMap Linkage Disequilibrium report
IL4I1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL4I1 Gene

Disorders for IL4I1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for IL4I1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
posterior myocardial infarction
  • posterior myocardial infarction nos
tricuspid valve insufficiency
  • tricuspid valve regurgitation
mitral valve insufficiency
  • congenital insufficiency of mitral valve
tricuspid valve stenosis
  • tricuspid stenosis
subvalvular aortic stenosis
  • aortic stenosis, subvalvular
- elite association
Search IL4I1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL4I1

Genetic Association Database (GAD)
IL4I1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL4I1
genes like me logo Genes that share disorders with IL4I1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL4I1 Gene

Publications for IL4I1 Gene

  1. Biochemical, functional and structural characterization of Akbu-LAAO: a novel snake venom L-amino acid oxidase from Agkistrodon blomhoffii ussurensis. (PMID: 20100538) Sun M.Z. … Liu S. (Biochimie 2010) 23 67
  2. Photoactive ligands probing the sweet taste receptor. Design and synthesis of highly potent diazirinyl D-phenylalanine derivatives. (PMID: 20031409) Masuda K. … Hashimoto M. (Bioorg. Med. Chem. Lett. 2010) 23 67
  3. Cytotoxic proteins of Amanita virosa Secr. mushroom: purification, characteristics and action towards mammalian cells. (PMID: 20153765) Antonyuk V.O. … Stoika R.S. (Toxicon 2010) 23 67
  4. A chiral ligand exchange CE essay with zinc(II)-L-valine complex for determining enzyme kinetic constant of L-amino acid oxidase. (PMID: 20441938) Qi L. … Qiao J. (Talanta 2010) 23 67
  5. Biochemistry and toxicology of toxins purified from the venom of the snake Bothrops asper. (PMID: 19111755) Angulo Y. … Lomonte B. (Toxicon 2009) 23 67

Products for IL4I1 Gene

Sources for IL4I1 Gene

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