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IL4I1 Gene

protein-coding   GIFtS: 51
GCID: GC19M050392

Interleukin 4 Induced 1

  See IL4I1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 4 Induced 11 2     Interleukin Four Induced 12
FIG12 3 5     L-Amino-Acid Oxidase2
LAAO2 3     EC 1.4.3.23
LAO2 3     hFIG13
IL4-Induced Protein 12 3     Interleukin-4-Induced Protein 13
Fig-1 Protein2     Protein Fig-13

External Ids:    HGNC: 190941   Entrez Gene: 2593072   Ensembl: ENSG000001049517   OMIM: 6097425   UniProtKB: Q96RQ93   

Export aliases for IL4I1 gene to outside databases

Previous GC identifers: GC19U990319 GC19M050741 GC19M055069 GC19M055065 GC19M055085 GC19M055070 GC19M055090 GC19M055092 GC19M055094 GC19M055096 GC19M055098 GC19M055099 GC19M055100 GC19M055106 GC19M055108 GC19M046769


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL4I1 Gene:
This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino
acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The
expression of this gene can be induced by interleukin 4 in B cells, however, expression of transcripts containing
the first two exons of the upstream gene is found in other cell types. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for IL4I1 Gene:
IL4I1 (interleukin 4 induced 1) is a protein-coding gene. Diseases associated with IL4I1 include perinephritis, and primary mediastinal large b-cell lymphoma.

UniProtKB/Swiss-Prot: OXLA_HUMAN, Q96RQ9
Function: Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in
lysosomal antigen processing and presentation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the IL4I1 gene promoter:
         SRY   Sp1   AP-1   ATF-2   p300   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL4I1 promoter sequence
   Search Chromatin IP Primers for IL4I1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL4I1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3-q13.4   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3-q13.4

IL4I1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL4I1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M050392:  view genomic region     (about GC identifiers)

Start:
50,392,911 bp from pter      End:
50,432,796 bp from pter
Size:
39,886 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OXLA_HUMAN, Q96RQ9 (See protein sequence)
Recommended Name: L-amino-acid oxidase precursor  
Size: 567 amino acids; 62881 Da
Cofactor: FAD (By similarity)
Sequence caution: Sequence=BAB84923.1; Type=Erroneous initiation; Sequence=CAI54291.1; Type=Erroneous initiation;
Sequence=CAI54292.1; Type=Erroneous initiation; Sequence=CAI54293.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for IL4I1:
2I8H (3D)    
Secondary accessions: Q1WMJ3 Q4GZN1 Q4GZN2 Q6P2Q3 Q8TEM5 Q96RQ8
Alternative promoter usage, Alternative splicing: 2 isoforms:  Q96RQ9-1   Q96RQ9-2   (Uses the promoter of the upstream NUP62 gene and shares the first 2 non-coding exons with NUP62)

Explore the universe of human proteins at neXtProt for IL4I1: NX_Q96RQ9

Explore proteomics data for IL4I1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn54, Asn134, Asn220, Asn559
  • Modification sites at PhosphoSitePlus

  • See IL4I1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001244946.1  NP_001244947.1  NP_690863.1  NP_758962.1  

    ENSEMBL proteins: 
     ENSP00000375702   ENSP00000469467   ENSP00000342557   ENSP00000472474   ENSP00000470120  
     ENSP00000471950   ENSP00000469841   ENSP00000472786  
    Reactome Protein details: Q96RQ9

    IL4I1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001613 Flavin_amine_oxidase
     IPR002937 Amino_oxidase

    Graphical View of Domain Structure for InterPro Entry Q96RQ9

    ProtoNet protein and cluster: Q96RQ9

    UniProtKB/Swiss-Prot: OXLA_HUMAN, Q96RQ9
    Similarity: Belongs to the flavin monoamine oxidase family. FIG1 subfamily


    Find genes that share domains with IL4I1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OXLA_HUMAN, Q96RQ9
    Function: Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in
    lysosomal antigen processing and presentation (By similarity)
    Catalytic activity: An L-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2)
    Induction: By IL4/interleukin-4

         Enzyme Number (IUBMB): EC 1.4.3.21

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001716L-amino-acid oxidase activity EXP--
    GO:0016491oxidoreductase activity ----
    GO:0050660flavin adenine dinucleotide binding ----
         
    Find genes that share ontologies with IL4I1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for IL4I1:
     Decreased Hepatitis C virus re  Small cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Il4i1):
     behavior/neurological 

    Find genes that share phenotypes with IL4I1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il4i1tm1Lex for IL4I1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL4I1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL4I1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OXLA_HUMAN, Q96RQ9: Isoform 1: Lysosome (By similarity)
    OXLA_HUMAN, Q96RQ9: Isoform 2: Lysosome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    nucleus4
    lysosome2
    plasma membrane2
    vacuole2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005764lysosome IEA--
    GO:0031965nuclear membrane ----
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with IL4I1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL4I1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Phenylalanine metabolism
    Phenylalanine metabolism0.36
    Phenylalanine, tyrosine and tryptophan biosynthesis0.00
    Tyrosine metabolism0.36
    2Tryptophan metabolism
    Tryptophan metabolism0.46
    3Metabolism
    Metabolic pathways0.38
    4Sulfur amino acid metabolism
    Cysteine and methionine metabolism0.35
    5Valine, leucine and isoleucine degradation
    Valine, leucine and isoleucine degradation0.31


    Find genes that share SuperPaths with IL4I1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for IL4I1
        Abnormal metabolism in phenylketonuria


    Selected Kegg Pathways  (Kegg details for IL4I1) (see all 8):
        Alanine, aspartate and glutamate metabolism
    Cysteine and methionine metabolism
    Valine, leucine and isoleucine degradation
    Tyrosine metabolism
    Phenylalanine metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IL4I1
    Interactions:

        Search GeneGlobe Interaction Network for IL4I1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL4I1 (ENSP000003425574) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADI1ENSP000003336664STRING: ENSP00000333666
    DDCENSP000003506164STRING: ENSP00000350616
    DDOENSP000003579204STRING: ENSP00000357920
    HPDENSP000002890044STRING: ENSP00000289004
    IDO1ENSP000002535134STRING: ENSP00000253513
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with IL4I1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL4I1 (OXLA)

    1 HMDB Compound for IL4I1    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--

    4 DrugBank Compounds for IL4I1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-Aminobenzoic Acid-- --target--17139284 17016423 10592235
    Citric Acid-- 77-92-9target--17139284 17016423 10592235
    Flavin-Adenine Dinucleotide-- 146-14-5target--17139284 17016423 10592235
    Vinylglycine(2s)-2-Amino-3-Butenoic Acid (see all 3)52773-87-2target--10592235

    Selected Novoseek inferred chemical compound relationships for IL4I1 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    l-amino acid 97.5 119 7886693 (7), 12175601 (4), 10727211 (3), 14636050 (3) (see all 75)
    achacin 88.8 3 14725862 (2), 10651042 (1)
    deae-sephadex a-50 75.6 2 7886693 (1), 20100538 (1)
    h2o2 54.9 7 9990127 (2), 11319613 (1), 7886693 (1), 16102046 (1) (see all 6)
    sephadex 49.4 3 1799979 (1), 7886693 (1), 20100538 (1)
    phenylalanine 47.4 5 17356132 (2), 8373154 (1), 7634379 (1)
    leucine 41.9 6 7917182 (2), 11738231 (1), 7634379 (1)
    agcl 40.5 1 8373154 (1)
    thromboxane a2 32.5 1 7886693 (1)
    adp 30.7 1 7886693 (1)



    Find genes that share compounds with IL4I1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL4I1 gene (4 alternative transcripts): 
    NM_001258017.1  NM_001258018.1  NM_152899.1  NM_172374.2  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391826(uc002pqt.1) ENST00000601717 ENST00000341114(uc021uxy.1 uc002pqu.2 uc010eno.2 uc002pqv.2)
    ENST00000595948 ENST00000593956 ENST00000596022 ENST00000597295 ENST00000596011

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    Selected AceView cDNA sequences (see all 756):

    CR592016 BG748660 BC051844 BE276236 AI807145 BU956767 BE792302 BC015562 
    CR595556 AI306584 NM_172374 AW673775 BC016043 AI160518 BQ773973 BE790884 
    BI091794 BG747031 BM561943 AI291614 BC064378 BQ893943 BU557259 AI138952 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IL4I1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12
    SP1:                                                                                                                        
    SP2:                                                                                                                        
    SP3:                                            -     -     -                                                               
    SP4:                                -     -     -     -     -                                                               
    SP5:                                      -     -     -     -                                                               


    ECgene alternative splicing isoforms for IL4I1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL4I1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IL4I1 Expression
    About this image

    IL4I1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL4I1 Protein Expression

    UniProtKB/Swiss-Prot: OXLA_HUMAN, Q96RQ9
    Tissue specificity: Isoform 1 is primarily found in immune tissues

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL4I1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL4I1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il4i11 , 5 interleukin 4 induced 11, 5 79.23(n)1
    79.96(a)1
      7 (28.93 cM)5
    142041  NM_010215.31  NP_034345.21 
     448163705 
    chicken
    (Gallus gallus)
    Aves IL4I16
    Gallus gallus interleukin 4 induced 1 (IL4I1), mRN...
    37(a)
    1 ↔ 1
    16(191143-194187)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    39(a)
    1 → many
    2(188962366-188972757)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.10782 Nuclear pore complex glycoprotein p62 [Xenopus laevis, more 78.09(n)    S59344.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-40g16.61 si:dkey-40g16.6 49.46(n)
    43.32(a)
      337166  XM_003200032.2  XP_003200080.1 


    ENSEMBL Gene Tree for IL4I1 (if available)
    TreeFam Gene Tree for IL4I1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for IL4I1 (see all 1060)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402382571,2
    C,F--46770604(+) GCCTCG/AGCGAA 9 /A syn11Minor allele frequency- A:0.01NA 4170
    rs355656341,2
    C--46792597(+) GTCAA-/ATGTCAG 4 -- int12Minor allele frequency- AT:0.25NA CSA 4
    rs561294901,2
    C--46798413(+) GGGGG-/G/G   
       G
    /GGG
    CGGGG
    4 -- int11NA 2
    rs1864246451,2
    --46798492(+) CTCTAC/TAAAAA 4 -- int10--------
    rs570849481,2
    C--46806384(+) TTTTT-/T/TTT 
            
    GAGAC
    4 -- int11NA 2
    rs2017341901,2
    --46809980(+) TTTTT-/TTCTGTAT 4 -- us2k10--------
    rs1447770601,2
    C--46809981(+) TTTTT-/TCTGTAT 4 -- us2k10--------
    rs1507225661,2
    C--46809982(+) TTTTT-/C/TT  
            
    TGTAT
    4 -- us2k11NA 2
    rs665377331,2
    C--50394204(-) CGGGC-/AGGGGGG 5 -- int11Minor allele frequency- AG:0.00NA 2
    rs38409211,2
    C--50399384(+) GCCCCC/-TCCCC 5 -- int1 trp31Minor allele frequency- -:0.00CSA 2

    HapMap Linkage Disequilibrium report for IL4I1 (50392911 - 50432796 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for IL4I1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv996372CNV Deletion20482838
    nsv912269CNV Loss21882294
    dgv54n68CNV Loss17160897
    dgv53n68CNV Loss17160897
    dgv3974n71CNV Loss21882294
    nsv524068CNV Loss19592680
    nsv2519CNV Loss18451855
    nsv458720CNV Gain19166990
    nsv9739CNV Gain+Loss18304495
    nsv7309OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for IL4I1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609742    OMIM disorders: --

    2 diseases for IL4I1:    
    About MalaCards
    perinephritis    primary mediastinal large b-cell lymphoma

    1 disease from the University of Copenhagen DISEASES database for IL4I1:
    Perinephritis

    Find genes that share disorders with IL4I1           About GenesLikeMe

    3 Novoseek inferred disease relationships for IL4I1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 13.4 2 8996517 (2)
    lymphoma b-cell 13.1 3 17356132 (2), 12446450 (1)
    bleeding 3.07 1 11368308 (1)

    Genetic Association Database (GAD): IL4I1

    Export disorders for IL4I1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL4I1 gene, integrated from 10 sources (see all 92):
    (articles sorted by number of sources associating them with IL4I1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human homolog of the IL-4 induced gene-1 (Fig1). (PubMed id 12031486)1, 2, 3 Chavan S.S.... Chu C.C. (Biochim. Biophys. Acta 2002)
    2. Alternative pre-mRNA processing regulates cell-type specific expression of the IL4l1 and NUP62 genes. (PubMed id 16029492)1, 2 Wiemann S.... Poustka A. (BMC Biol. 2005)
    3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation. (PubMed id 17356132)1, 9 Boulland M.L....Castellano F. (Blood 2007)
    7. Interleukin 4-induced gene 1 is activated in primary mediastinal large B-cell lymphoma. (PubMed id 12446450)1, 9 Copie-Bergman C....Leroy K. (Blood 2003)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Antibacterial properties of the mammalian L-amino acid oxidase IL4I1. (PubMed id 23355881)1 Puiffe M.L....Castellano F. (PLoS ONE 2013)
    10. Dichotomy between factors inducing the immunosuppressive enzyme IL-4-induced gene 1 (IL4I1) in B lymphocytes and mononuclear phagocytes. (PubMed id 20683900)1 Marquet J....Castellano F. (Eur. J. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 259307 HGNC: 19094 AceView: NUP62 Ensembl:ENSG00000104951 euGenes: HUgn259307
    ECgene: IL4I1 Kegg: 259307 H-InvDB: IL4I1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL4I1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL4I1 gene:
    Search GeneIP for patents involving IL4I1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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