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Aliases for IL4I1 Gene

Aliases for IL4I1 Gene

  • Interleukin 4 Induced 1 2 3 5
  • IL4-Induced Protein 1 3 4
  • FIG1 3 4
  • LAAO 3 4
  • LAO 3 4
  • Interleukin-4-Induced Protein 1 4
  • Interleukin Four Induced 1 3
  • L-Amino-Acid Oxidase 3
  • Fig-1 Protein 3
  • Protein Fig-1 4
  • EC 4
  • HFIG1 4

External Ids for IL4I1 Gene

Previous GeneCards Identifiers for IL4I1 Gene

  • GC19U990319
  • GC19M050741
  • GC19M055069
  • GC19M055065
  • GC19M055085
  • GC19M055070
  • GC19M055090
  • GC19M055092
  • GC19M055094
  • GC19M055096
  • GC19M055098
  • GC19M055099
  • GC19M055100
  • GC19M055106
  • GC19M055108
  • GC19M050392
  • GC19M046769

Summaries for IL4I1 Gene

Entrez Gene Summary for IL4I1 Gene

  • This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The expression of this gene can be induced by interleukin 4 in B cells, however, expression of transcripts containing the first two exons of the upstream gene is found in other cell types. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for IL4I1 Gene

IL4I1 (Interleukin 4 Induced 1) is a Protein Coding gene. Diseases associated with IL4I1 include Posterior Myocardial Infarction and Mitral Valve Insufficiency. Among its related pathways are Tyrosine metabolism and Viral mRNA Translation. GO annotations related to this gene include oxidoreductase activity and L-amino-acid oxidase activity.

UniProtKB/Swiss-Prot for IL4I1 Gene

  • Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL4I1 Gene

Genomics for IL4I1 Gene

Regulatory Elements for IL4I1 Gene

Enhancers for IL4I1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G049910 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7.7 +17.6 17551 3.9 HDGF PKNOX1 ATF1 AGO1 WRNIP1 ARID4B GLI4 ZNF48 ZNF2 ZNF121 NUP62 AKT1S1 POLD1 SNORD35A TBC1D17 PTOV1 PRR12 PIH1D1 PTOV1-AS2 ENSG00000221125
GH19G050003 1.2 Ensembl ENCODE 10.9 -74.8 -74817 1.9 HDAC1 HDGF ATF1 AGO1 ZSCAN4 INSM2 SIN3A ZEB1 ZNF766 ZNF366 VRK3 ZNF473 DKKL1 IL4I1 NUP62 ATF5 SIGLEC16 SIGLEC11 ENSG00000276729
GH19G049921 1.6 FANTOM5 ENCODE dbSUPER 8.1 +6.5 6518 3.4 WRNIP1 YY1 ZNF121 ZNF766 ELK1 ZNF143 FOS KLF7 SP3 CAVIN1 FCGRT NUP62 FLT3LG IL4I1 NR1H2 PTOV1-AS1 ATF5 RPS11 PIR32099
GH19G049983 0.8 ENCODE 11.8 -54.3 -54280 0.2 HDGF CBX3 RB1 TBL1XR1 ARID4B RAD21 CBX5 SCRT2 ZNF143 ZNF207 SIGLEC16 ENSG00000221125 NUP62 IL4I1 ATF5 ENSG00000276729
GH19G049980 0.8 ENCODE 11.8 -52.7 -52677 2.6 CTCF CBX3 TAL1 ZNF266 ZMYM3 UBTF FOSL1 TCF12 FOXM1 GATA2 SIGLEC16 VRK3 SIGLEC11 ENSG00000221125 NUP62 IL4I1 ATF5 ZNF473 ENSG00000276729
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL4I1 on UCSC Golden Path with GeneCards custom track

Promoters for IL4I1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110984 139 2401 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for IL4I1 Gene

49,889,654 bp from pter
49,929,539 bp from pter
39,886 bases
Minus strand

Genomic View for IL4I1 Gene

Genes around IL4I1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL4I1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL4I1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL4I1 Gene

Proteins for IL4I1 Gene

  • Protein details for IL4I1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    L-amino-acid oxidase
    Protein Accession:
    Secondary Accessions:
    • Q1WMJ3
    • Q4GZN1
    • Q4GZN2
    • Q6P2Q3
    • Q8TEM5
    • Q96RQ8

    Protein attributes for IL4I1 Gene

    567 amino acids
    Molecular mass:
    62881 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    • Sequence=BAB84923.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI54291.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI54292.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI54293.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL4I1 Gene

    Alternative splice isoforms for IL4I1 Gene


neXtProt entry for IL4I1 Gene

Post-translational modifications for IL4I1 Gene

  • Glycosylation at posLast=5454, posLast=134134, posLast=220220, and posLast=559559
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IL4I1 Gene

Domains & Families for IL4I1 Gene

Protein Domains for IL4I1 Gene

Suggested Antigen Peptide Sequences for IL4I1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
  • Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
genes like me logo Genes that share domains with IL4I1: view

No data available for Gene Families for IL4I1 Gene

Function for IL4I1 Gene

Molecular function for IL4I1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
An L-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity).
UniProtKB/Swiss-Prot Induction:
By IL4/interleukin-4.

Enzyme Numbers (IUBMB) for IL4I1 Gene

Gene Ontology (GO) - Molecular Function for IL4I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001716 L-amino-acid oxidase activity EXP 17356132
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with IL4I1: view
genes like me logo Genes that share phenotypes with IL4I1: view

Animal Models for IL4I1 Gene

MGI Knock Outs for IL4I1:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL4I1

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IL4I1 Gene

Localization for IL4I1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL4I1 Gene

Isoform 1: Lysosome.
Isoform 2: Lysosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL4I1 gene
Compartment Confidence
extracellular 5
lysosome 4
plasma membrane 3
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL4I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005764 lysosome IEA --
genes like me logo Genes that share ontologies with IL4I1: view

Pathways & Interactions for IL4I1 Gene

genes like me logo Genes that share pathways with IL4I1: view

Gene Ontology (GO) - Biological Process for IL4I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006559 L-phenylalanine catabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with IL4I1: view

No data available for SIGNOR curated interactions for IL4I1 Gene

Drugs & Compounds for IL4I1 Gene

(22) Drugs for IL4I1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma Target 0
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
L-Aspartic acid Approved Nutra 0
L-Isoleucine Approved Nutra 0

(20) Additional Compounds for IL4I1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Oxo-4-methylthiobutanoic acid
  • 2-Keto-4-methylthiobutyrate
  • 2-Keto-4-methylthiobutyric acid
  • 2-Ketomethiobutyrate
  • 2-Oxo-4-methylthiobutanoate
  • 2-Oxo-4-methylthiobutanoic acid
3-Methyl-2-oxovaleric acid
  • (3R)-3-Methyl-2-oxopentanoate
  • (3R)-3-Methyl-2-oxopentanoic acid
  • (R)-3-methyl-2-oxopentanoate
  • (R)-3-methyl-2-oxopentanoic acid
  • (S)-3-methyl-2-oxopentanoate
4-Hydroxyphenylpyruvic acid
  • (p-hydroxyphenyl)-Pyruvate
  • (p-hydroxyphenyl)-Pyruvic acid
  • (p-Hydroxyphenyl)pyruvate
  • (p-Hydroxyphenyl)pyruvic acid
  • 3-(4-Hydroxyphenyl)-2-oxo-propanoate
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
  • (indol-3-yl)pyruvic acid
  • indole-3-pyruvic acid
  • Indolepyruvic acid
genes like me logo Genes that share compounds with IL4I1: view

Transcripts for IL4I1 Gene

Unigene Clusters for IL4I1 Gene

Interleukin 4 induced 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL4I1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: - -
SP7: -

Relevant External Links for IL4I1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL4I1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL4I1 Gene

mRNA differential expression in normal tissues according to GTEx for IL4I1 Gene

This gene is overexpressed in Testis (x8.3).

Protein differential expression in normal tissues from HIPED for IL4I1 Gene

This gene is overexpressed in Lung (20.7), Lymph node (13.2), Peripheral blood mononuclear cells (9.9), and Testis (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL4I1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL4I1 Gene:


SOURCE GeneReport for Unigene cluster for IL4I1 Gene:


mRNA Expression by UniProt/SwissProt for IL4I1 Gene:

Tissue specificity: Isoform 1 is primarily found in immune tissues.

Evidence on tissue expression from TISSUES for IL4I1 Gene

  • Spleen(4.3)
  • Liver(4)
  • Nervous system(4)
  • Blood(2.2)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with IL4I1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL4I1 Gene

Orthologs for IL4I1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IL4I1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL4I1 35 34
  • 98.51 (n)
(Canis familiaris)
Mammalia IL4I1 35 34
  • 81.79 (n)
(Mus musculus)
Mammalia Il4i1 34 16 35
  • 79.23 (n)
(Rattus norvegicus)
Mammalia LOC100360621 34
  • 77.97 (n)
(Bos Taurus)
Mammalia IL4I1 35
  • 74 (a)
(Monodelphis domestica)
Mammalia IL4I1 35
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia IL4I1 35
  • 44 (a)
(Gallus gallus)
Aves IL4I1 35
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493881 34
  • 49.15 (n)
LOC394934 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1078 34
(Danio rerio)
Actinopterygii si:dkey-40g16.6 34
  • 49.46 (n)
IL4I1 35
  • 41 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11911 34
bread mold
(Neurospora crassa)
Ascomycetes NCU01066 34
  • 45.52 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2768 34
Species where no ortholog for IL4I1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL4I1 Gene

Gene Tree for IL4I1 (if available)
Gene Tree for IL4I1 (if available)

Paralogs for IL4I1 Gene

No data available for Paralogs for IL4I1 Gene

Variants for IL4I1 Gene

Sequence variations from dbSNP and Humsavar for IL4I1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs121917865 Pathogenic 49,908,636(-) GGACC(A/C)GGAGC intron-variant, reference, missense
rs1062798 Likely benign 49,908,960(-) cacca(C/G)cagca intron-variant, reference, missense
rs1984656 Likely benign 49,909,259(+) GGTGC(C/G/T)GTGGG intron-variant, reference, synonymous-codon
rs892028 Likely benign 49,908,485(-) ATCGA(C/G/T)GCACA intron-variant, reference, synonymous-codon
rs999583 Likely benign 49,909,160(+) CCAGT(A/G)CTGGT intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IL4I1 Gene

Variant ID Type Subtype PubMed ID
dgv53n68 CNV loss 17160897
dgv54n68 CNV loss 17160897
esv3583457 CNV loss 25503493
esv3644628 CNV gain 21293372
esv3644630 CNV gain 21293372
esv996372 CNV deletion 20482838
nsv1058623 CNV gain 25217958
nsv1065648 CNV gain 25217958
nsv1131436 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv2519 CNV deletion 18451855
nsv458720 CNV gain 19166990
nsv524068 CNV loss 19592680
nsv579910 CNV gain 21841781
nsv7309 OTHER inversion 18451855
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for IL4I1 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL4I1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL4I1 Gene

Disorders for IL4I1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for IL4I1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
posterior myocardial infarction
  • posterior myocardial infarction nos
mitral valve insufficiency
  • congenital insufficiency of mitral valve
tricuspid valve stenosis
  • tricuspid stenosis
aortic valve disease 1
  • aortic valve disease
- elite association - COSMIC cancer census association via MalaCards
Search IL4I1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL4I1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IL4I1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL4I1 Gene

Publications for IL4I1 Gene

  1. Characterization of the human homolog of the IL-4 induced gene-1 (Fig1). (PMID: 12031486) Chavan S.S. … Chu C.C. (Biochim. Biophys. Acta 2002) 2 3 4 64
  2. Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation. (PMID: 17356132) Boulland M.L. … Castellano F. (Blood 2007) 3 22 64
  3. Alternative pre-mRNA processing regulates cell-type specific expression of the IL4l1 and NUP62 genes. (PMID: 16029492) Wiemann S. … Poustka A. (BMC Biol. 2005) 3 4 64
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for IL4I1 Gene

Sources for IL4I1 Gene

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