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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL4I1 Gene

protein-coding GIFtS: 51
GCID: GC19M050392

interleukin 4 induced 1

Explore 6 diseases affiliated with
IL4I1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 4 Induced 1¹ ²		Interleukin Four Induced 1²
FIG1¹ ² ³ ⁵		L-Amino-Acid Oxidase²
LAAO² ³		EC 1.4.3.2³
LAO² ³		HFIG1¹
IL4-Induced Protein 1² ³		Interleukin-4-Induced Protein 1³
Fig-1 Protein²		Protein Fig-1³

External Ids:	HGNC: 19094¹	Entrez Gene: 259307²	Ensembl: ENSG00000104951⁷	OMIM: 609742⁵	UniProtKB: Q96RQ9³

Export aliases for IL4I1 gene to outside databases

Previous GC identifers: GC19U990319 GC19M050741 GC19M055069 GC19M055065 GC19M055085 GC19M055070 GC19M055090 GC19M055092 GC19M055094 GC19M055096 GC19M055098 GC19M055099 GC19M055100 GC19M055106 GC19M055108 GC19M046769

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL4I1:

This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids

thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The expression of this

gene can be induced by interleukin 4 in B cells, however, expression of transcripts containing the first two exons of

the upstream gene is found in other cell types. Multiple transcript variants encoding different isoforms have been

found for this gene. (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: OXLA_HUMAN, Q96RQ9

Function: Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in

lysosomal antigen processing and presentation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL4I1 gene promoter:
SRY Sp1 AP-1 ATF-2 p300 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL4I1 promoter sequence

Search SABiosciences Chromatin IP Primers for IL4I1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL4I1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3-q13.4 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3-q13.4

IL4I1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL4I1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M050392: view genomic region (about GC identifiers)

Start:	50,392,911 bp from pter	End:	50,432,796 bp from pter
Size:	39,886 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OXLA_HUMAN, Q96RQ9 (See protein sequence)

Recommended Name: L-amino-acid oxidase precursor

Size: 567 amino acids; 62881 Da

Cofactor: FAD (By similarity)

Subcellular location: Isoform 1: Lysosome (By similarity)

Subcellular location: Isoform 2: Lysosome (By similarity)

Sequence caution: Sequence=BAB84923.1; Type=Erroneous initiation; Sequence=CAI54291.1; Type=Erroneous initiation;

Sequence=CAI54292.1; Type=Erroneous initiation; Sequence=CAI54293.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for IL4I1:

2I8H (3D)

Secondary accessions: Q1WMJ3 Q4GZN1 Q4GZN2 Q6P2Q3 Q8TEM5 Q96RQ8

Alternative promoter usage, Alternative splicing: 2 isoforms: Q96RQ9-1 Q96RQ9-2 (Uses the promoter of the upstream NUP62 gene and shares the first 2 non-coding exons with NUP62)

Explore the universe of human proteins at neXtProt for IL4I1: NX_Q96RQ9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96RQ9

IL4I1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001244946.1 NP_001244947.1 NP_690863.1 NP_758962.1

ENSEMBL proteins:

ENSP00000342557 ENSP00000375702

Reactome Protein details: Q96RQ9
Human Recombinant Protein Products for IL4I1:

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	Uscn Proteins for IL4I1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005764	lysosome	IEA	--
GO:0031965	nuclear membrane	IDA	--
GO:0043231	intracellular membrane-bounded organelle	IDA	--

IL4I1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for IL4I1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL4I1 for domains About GeneDecksing

2 InterPro domains/families:

IPR001613 Flavin_amine_oxidase

IPR002937 Amino_oxidase

Graphical View of Domain Structure for InterPro Entry Q96RQ9

ProtoNet protein and cluster: Q96RQ9

UniProtKB/Swiss-Prot: OXLA_HUMAN, Q96RQ9

Similarity: Belongs to the flavin monoamine oxidase family. FIG1 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: OXLA_HUMAN, Q96RQ9

Function: Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in

lysosomal antigen processing and presentation (By similarity)

Catalytic activity: An L-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2)

Induction: By IL4/interleukin-4

Enzyme Number (IUBMB): EC 1.4.3.2¹

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001716	L-amino-acid oxidase activity	EXP	--

IL4I1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for IL4I1:

Decreased Hepatitis C virus re

Small cells

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Il4i1):

behavior/neurological

IL4I1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Il4i1^tm1Lex for IL4I1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IL4I1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL4I1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Tyrosine metabolism

Tyrosine metabolism

1.00

Phenylalanine metabolism

0.35

Abnormal metabolism in phenylketonuria

Abnormal metabolism in phenylketonuria

1.00

Disease

Disease

1.00

Alanine, aspartate and glutamate metabolism

Alanine, aspartate and glutamate metabolism

1.00

Tryptophan metabolism

Tryptophan metabolism

0.47

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for IL4I1

	Abnormal metabolism in phenylketonuria
	Disease

5/8 Kegg Pathways (Kegg details for IL4I1) (see all 8):

	Alanine, aspartate and glutamate metabolism
	Cysteine and methionine metabolism
	Valine, leucine and isoleucine degradation
	Tyrosine metabolism
	Phenylalanine metabolism

IL4I1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IL4I1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/69 Interacting proteins for IL4I1 (ENSP00000342557⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 69)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADI1	ENSP00000333666⁴	STRING: ENSP00000333666
DDC	ENSP00000350616⁴	STRING: ENSP00000350616
DDO	ENSP00000357920⁴	STRING: ENSP00000357920
IDO1	ENSP00000253513⁴	STRING: ENSP00000253513
PAH	ENSP00000303500⁴	STRING: ENSP00000303500

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009072	aromatic amino acid family metabolic process	--	--

IL4I1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL4I1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL4I1

1 HMDB Compound for IL4I1 About this table

Compound	Synonyms	CAS #	PubMed Ids
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--

4 DrugBank Compounds for IL4I1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
2-Aminobenzoic Acid	--	--	target	--	17139284 17016423 10592235
Citric Acid	--	77-92-9	target	--	17139284 17016423 10592235
Flavin-Adenine Dinucleotide	--	146-14-5	target	--	17139284 17016423 10592235
Vinylglycine	(2s)-2-Amino-3-Butenoic Acid (see all 3)	52773-87-2	target	--	10592235

10/23 Novoseek chemical compound relationships for IL4I1 gene (see all 23) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
l-amino acid	97.5	119	7886693 (7), 12175601 (4), 10727211 (3), 14636050 (3) (see all 75)
achacin	88.8	3	14725862 (2), 10651042 (1)
deae-sephadex a-50	75.6	2	7886693 (1), 20100538 (1)
h2o2	54.9	7	9990127 (2), 11319613 (1), 7886693 (1), 16102046 (1) (see all 6)
sephadex	49.4	3	1799979 (1), 7886693 (1), 20100538 (1)
phenylalanine	47.4	5	17356132 (2), 8373154 (1), 7634379 (1)
leucine	41.9	6	7917182 (2), 11738231 (1), 7634379 (1)
agcl	40.5	1	8373154 (1)
thromboxane a2	32.5	1	7886693 (1)
adp	30.7	1	7886693 (1)

Search CenterWatch for drugs/clinical trials and news about IL4I1 / OXLA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL4I1 gene (4 alternative transcripts):

NM_001258017.1 NM_001258018.1 NM_152899.1 NM_172374.2

Unigene Cluster for IL4I1:

Interleukin 4 induced 1

Hs.741750 [show with all ESTs]

Unigene Representative Sequence: DQ079588

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000341114(uc021uxy.1 uc002pqu.2 uc010eno.2 uc002pqv.2)

ENST00000391826(uc002pqt.1)

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Additional cDNA sequence:

AF293462.1 AJ880386.1 AJ880387.1 AJ880388.1 AJ880389.1 AY358933.1 BC026103.1 BC064378.1

BC090852.1 BC131625.1 DQ079587.1 DQ079588.1 DQ079589.1 NR_047577.1

8 DOTS entries:

DT.100691261 DT.99930672 DT.121429419 DT.100878766 DT.121429366 DT.95157130 DT.121429370 DT.121429354

24/756 AceView cDNA sequences (see all 756):

BQ935203 AI203875 AI306584 CD251963 BU172886 BG763988 AI138952 AA731646

BF796391 AI869032 AI864949 AI215639 AI139287 CR604133 CA867288 NM_172374

AI621353 AI307671 BE790884 BU838108 BE266385 BE276236 AA435912 AA620777

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for IL4I1 (see all 9) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	·	8d	^	9	^	10	^	11a	·	11b	·	11c	^	12
SP1:
SP2:
SP3:															-		-		-
SP4:											-		-		-		-		-
SP5:													-		-		-		-

ECgene alternative splicing isoforms for IL4I1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL4I1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See IL4I1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL4I1

SOURCE GeneReport for Unigene cluster: Hs.741750

UniProtKB/Swiss-Prot: OXLA_HUMAN, Q96RQ9

Tissue specificity: Isoform 1 is primarily found in immune tissues

SABiosciences Custom PCR Arrays for IL4I1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL4I1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL4I1 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il4i1⁵	interleukin 4 induced 1	--		7 (28.93 cM) 44816370
chicken (Gallus gallus)	Aves	IL4I1⁶	Uncharacterized protein	38(a)	1 ↔ 1	16(163943-166969)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1078²	Nuclear pore complex glycoprotein p62 [Xenopus laevis, more	78.09(n)		S59344.1
zebrafish (Danio rerio)	Actinopterygii	wu:fa99f01⁶	wu:fa99f01	42(a)	1 ↔ 1	15(20656626-20663487)

ENSEMBL Gene Tree for IL4I1 (if available)
TreeFam Gene Tree for IL4I1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IL4I1 gene

MAOB² MAOA²

IL4I1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111751469^1,2		--	46770262(+)	`TTGCCA/CCACCC`	5	--	int¹		1		CSA	1
rs12460287^1,2	C,F,H	--	46771833(+)	`cacacC/Ttggct`	5	--	int¹		5		NS EA NA	424
rs59466564^1,2	C,F	--	46772599(+)	`AGGGTG/AATACA`	5	--	int¹		1		WA	118
rs78944644^1,2		--	46772660(+)	`TGAGGA/CCAAAA`	5	--	int¹		1		WA	118
rs73068085^1,2	C	--	46773149(+)	`AGATGC/TCTCCA`	5	--	int¹		0	--	--	--	--
rs35736295^1,2	C	--	46774918(+)	`GTATGG/-GAGGT`	5	--	int¹		2		NA CSA	4
rs73934061^1,2	C	--	46775260(+)	`GGCCTC/TACCCC`	5	--	int¹		1		WA	2
rs73068086^1,2		--	46775281(+)	`GGAAAC/GATAGC`	5	--	int¹		0	--	--	--	--
rs112638174^1,2	C,F	--	46775670(+)	`GTCAAC/TGGGGT`	5	--	int¹		2		WA CSA	4
rs113736680^1,2	F	--	46775673(+)	`AACGGG/AGTTGT`	5	--	int¹		2		CSA	4

HapMap Linkage Disequilibrium report for IL4I1 (50392911 - 50432796 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for IL4I1
2 CNVs: 5114 32261
2 Inversions: 37207 37208

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL4I1 for disorders           About GeneDecksing

OMIM gene information: 609742    OMIM disorders: --

6 diseases for IL4I1:    About MalaCards

gas gangrene acute kidney tubular necrosis perinephritis b-cell lymphomas

mediastinitis prostatitis

3 Novoseek disease relationships for IL4I1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glioma	13.4	2	8996517 (2)
lymphoma b-cell	13.1	3	17356132 (2), 12446450 (1)
bleeding	3.07	1	11368308 (1)

Export disorders for IL4I1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for IL4I1 gene, integrated from 9 sources (see all 90):
(articles sorted by number of sources associating them with IL4I1)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of the human homolog of the IL-4 induced gene-1 (Fig1). (PubMed id 12031486)^{1, 2, 3} Chavan S.S.... Chu C.C. (2002)
Alternative pre-mRNA processing regulates cell-type specific expression of the IL4l1 and NUP62 genes. (PubMed id 16029492)^{1, 2} Wiemann S.... Poustka A. (2005)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation. (PubMed id 17356132)^{1, 9} Boulland M.L....Castellano F. (2007)
Interleukin 4-induced gene 1 is activated in primary mediastinal large B-cell lymphoma. (PubMed id 12446450)^{1, 9} Copie-Bergman C....Leroy K. (2003)
Dichotomy between factors inducing the immunosuppress ive enzyme IL-4-induced gene 1 (IL4I1) in B lymphocytes and mononuclear phagocy tes. (PubMed id 20683900)¹ Marquet J....Castellano F. (2010)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)² Chen R.... Zou H. (2009)
The novel immunosuppressive enzyme IL4I1 is expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrop hages. (PubMed id 19436310)¹ Carbonnelle-Puscian A....Molinier-Frenkel V. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 259307	HGNC: 19094	AceView: NUP62	Ensembl:ENSG00000104951	euGenes: HUgn259307
ECgene: IL4I1	Kegg: 259307	H-InvDB: IL4I1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL4I1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IL4I1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IL4I1 gene:
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GeneCards and IP:
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