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Aliases for IL4 Gene

Aliases for IL4 Gene

  • Interleukin 4 2 3 5
  • Lymphocyte Stimulatory Factor 1 2 3 4
  • B_cell Stimulatory Factor 1 2 3
  • B Cell Growth Factor 1 2 3
  • Binetrakin 3 4
  • Pitrakinra 3 4
  • BSF-1 3 4
  • IL-4 3 4
  • B-Cell Stimulatory Factor 1 4
  • Interleukin 4 Variant 2 3
  • Interleukin-4 3
  • BCGF-1 3
  • BCGF1 3
  • BSF1 3

External Ids for IL4 Gene

Previous GeneCards Identifiers for IL4 Gene

  • GC05P131531
  • GC05P132456
  • GC05P132041
  • GC05P132085
  • GC05P132037
  • GC05P132009
  • GC05P127201

Summaries for IL4 Gene

Entrez Gene Summary for IL4 Gene

  • The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL4 Gene

IL4 (Interleukin 4) is a Protein Coding gene. Diseases associated with IL4 include Allergic Bronchopulmonary Aspergillosis and Schistosomiasis. Among its related pathways are Immune System and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include cytokine activity and cytokine receptor binding.

UniProtKB/Swiss-Prot for IL4 Gene

  • Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity).

Gene Wiki entry for IL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL4 Gene

Genomics for IL4 Gene

Regulatory Elements for IL4 Gene

Enhancers for IL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F132812 0.8 ENCODE 23.9 +141.6 141617 5.4 CBX3 YY1 GLIS2 EGR2 ZNF202 ZNF263 ZNF362 ZNF280D CEBPB ZEB2 IL4 GDF9 RAD50 AFF4 RNU7-15P RNA5SP192 CCNI2 UQCRQ KIF3A ZCCHC10
GH05F132292 1.3 FANTOM5 ENCODE 22.7 -379.0 -378967 5.2 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF548 LOC553103 AFF4 IL4 RAD50 SLC22A5 FNIP1 SLC22A4 ENSG00000202533 ZCCHC10 ENSG00000248648
GH05F133048 0.6 ENCODE 22.7 +377.1 377115 5.5 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 AFF4 IL4 RAD50 HSPA4 MIR3936 ENSG00000224431 ENSG00000202533 GC05M133049 GC05M133050
GH05F132362 1.1 Ensembl ENCODE 22.1 -309.3 -309257 4.6 SIN3A FEZF1 BRCA1 ZNF2 YY1 TSHZ1 ZNF518A ZNF264 MAFF PBX2 LOC553103 RAD50 AFF4 IL4 ENSG00000202533 P4HA2 SLC22A4 FNIP1 PDLIM4 IL5
GH05F132276 1.2 Ensembl ENCODE 12.6 -395.2 -395240 3.8 CTCF PKNOX1 CBX3 ZBTB40 CHAMP1 ZFHX2 ZNF316 ZNF366 POLR2A EGR1 ENSG00000202533 IL4 LOC105379175 P4HA2-AS1 LOC107987500 LOC553103 SLC22A5 RAPGEF6 MEIKIN IL5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL4 Gene

Chromosome:
5
Start:
132,673,986 bp from pter
End:
132,682,678 bp from pter
Size:
8,693 bases
Orientation:
Plus strand

Genomic View for IL4 Gene

Genes around IL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL4 Gene

Proteins for IL4 Gene

  • Protein details for IL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05112-IL4_HUMAN
    Recommended name:
    Interleukin-4
    Protein Accession:
    P05112
    Secondary Accessions:
    • Q14630
    • Q6NZ77

    Protein attributes for IL4 Gene

    Size:
    153 amino acids
    Molecular mass:
    17492 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL4 Gene

    Alternative splice isoforms for IL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL4 Gene

Post-translational modifications for IL4 Gene

  • Glycosylation at Asn 62
  • Modification sites at PhosphoSitePlus

Other Protein References for IL4 Gene

No data available for DME Specific Peptides for IL4 Gene

Domains & Families for IL4 Gene

Gene Families for IL4 Gene

Graphical View of Domain Structure for InterPro Entry

P05112

UniProtKB/Swiss-Prot:

IL4_HUMAN :
  • Belongs to the IL-4/IL-13 family.
Family:
  • Belongs to the IL-4/IL-13 family.
genes like me logo Genes that share domains with IL4: view

Function for IL4 Gene

Molecular function for IL4 Gene

GENATLAS Biochemistry:
interleukin 4,15kDa,B-cell stimulating factor 1,important switch factor directing Ig-E synthesis
UniProtKB/Swiss-Prot Function:
Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity).

LifeMap Function Summary for IL4 Gene

It affects the following cells:
IL4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for IL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding IEA --
GO:0005136 interleukin-4 receptor binding IEA,TAS 11418631
GO:0005515 protein binding IPI 8266078
GO:0008083 growth factor activity IEA,NAS 11418631
genes like me logo Genes that share ontologies with IL4: view
genes like me logo Genes that share phenotypes with IL4: view

Animal Models for IL4 Gene

MGI Knock Outs for IL4:

Animal Model Products

miRNA for IL4 Gene

miRTarBase miRNAs that target IL4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IL4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL4 Gene

Localization for IL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL4 Gene COMPARTMENTS Subcellular localization image for IL4 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3
nucleus 3
cytoskeleton 2
lysosome 2
mitochondrion 2
vacuole 2
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,TAS 11418631
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with IL4: view

Pathways & Interactions for IL4 Gene

genes like me logo Genes that share pathways with IL4: view

SIGNOR curated interactions for IL4 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002227 innate immune response in mucosa IEA --
GO:0002230 positive regulation of defense response to virus by host IEA --
GO:0002296 T-helper 1 cell lineage commitment IEA --
genes like me logo Genes that share ontologies with IL4: view

Drugs & Compounds for IL4 Gene

(90) Drugs for IL4 Gene - From: PharmGKB, ClinicalTrials, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Histamine Approved Pharma Full agonist, Agonist 1034
Montelukast Approved Pharma Antagonist 266
Calcitriol Approved Nutra TNF-α and IL-1β production inhibitor, Vitamin D receptor (VDR) agonist 201
Aspirin Approved, Vet_approved Pharma Channel blocker 1112
Coal tar Approved Pharma 191

(41) Additional Compounds for IL4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for IL4 Gene

Compound Action Cas Number
Calcitriol TNF-α and IL-1β production inhibitor 32222-06-3
Suplatast Tosylate 94055-76-2
genes like me logo Genes that share compounds with IL4: view

Transcripts for IL4 Gene

mRNA/cDNA for IL4 Gene

Unigene Clusters for IL4 Gene

Interleukin 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IL4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for IL4 Gene

GeneLoc Exon Structure for
IL4
ECgene alternative splicing isoforms for
IL4

Expression for IL4 Gene

mRNA expression in normal human tissues for IL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL4 Gene

This gene is overexpressed in Pituitary (x4.7).

Protein differential expression in normal tissues from HIPED for IL4 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL4 Gene



Protein tissue co-expression partners for IL4 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL4 Gene:

IL4

SOURCE GeneReport for Unigene cluster for IL4 Gene:

Hs.73917
genes like me logo Genes that share expression patterns with IL4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IL4 Gene

Orthologs for IL4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL4 34 35
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia IL4 34 35
  • 75.19 (n)
dog
(Canis familiaris)
Mammalia IL4 34 35
  • 72.26 (n)
rat
(Rattus norvegicus)
Mammalia Il4 34
  • 60.91 (n)
mouse
(Mus musculus)
Mammalia Il4 34 16 35
  • 57.79 (n)
Species where no ortholog for IL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL4 Gene

ENSEMBL:
Gene Tree for IL4 (if available)
TreeFam:
Gene Tree for IL4 (if available)

Paralogs for IL4 Gene

No data available for Paralogs for IL4 Gene

Variants for IL4 Gene

Sequence variations from dbSNP and Humsavar for IL4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10058157 -- 132,672,519(+) gcagg(A/C/T)gcctg upstream-variant-2KB
rs10065221 -- 132,672,516(+) gtggc(A/G)ggtgc upstream-variant-2KB
rs10080170 -- 132,672,443(+) gagat(G/T)gagac upstream-variant-2KB
rs111434357 -- 132,675,850(+) GTTTA(-/TGTGTGTG)TGTGT intron-variant
rs111838390 -- 132,675,895(+) TGTGT(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL4 Gene

Variant ID Type Subtype PubMed ID
dgv28e197 CNV deletion 19546169
esv2348204 CNV deletion 18987734
esv2730791 CNV deletion 23290073
esv2730792 CNV deletion 23290073
esv2730793 CNV deletion 23290073
nsv528281 CNV gain 19592680
nsv529021 CNV loss 19592680

Variation tolerance for IL4 Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL4 Gene

Human Gene Mutation Database (HGMD)
IL4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL4 Gene

Disorders for IL4 Gene

MalaCards: The human disease database

(166) MalaCards diseases for IL4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
allergic bronchopulmonary aspergillosis
  • pulmonary aspergillus disease
schistosomiasis
  • katayama fever
vernal conjunctivitis
  • conjunctivitis vernal
allergic hypersensitivity disease
  • allergic disease
leishmaniasis
  • cutaneous leishmaniasis
- elite association - COSMIC cancer census association via MalaCards
Search IL4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IL4_HUMAN
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269 PubMed:14681304}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for IL4

Genetic Association Database (GAD)
IL4
Human Genome Epidemiology (HuGE) Navigator
IL4
Tumor Gene Database (TGDB):
IL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL4
genes like me logo Genes that share disorders with IL4: view

No data available for Genatlas for IL4 Gene

Publications for IL4 Gene

  1. Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion. (PMID: 19347053) Steinbrugger I. … Weger M. (Mol. Vis. 2009) 3 22 46 64
  2. Common polymorphisms in interleukin genes (IL4, IL6, IL8 and IL12) are not associated with alcoholic liver disease or alcoholism in Spanish men. (PMID: 19185507) Marcos M. … Laso F.J. (Cytokine 2009) 3 22 46 64
  3. Polymorphisms of RANTES and IL-4 genes in cerebral infarction. (PMID: 18696265) Um J.Y. … Kim H.M. (J. Mol. Neurosci. 2009) 3 22 46 64
  4. Genetic variants in immunoregulatory genes and risk for childhood lymphomas. (PMID: 19508433) Andrie E. … Petridou E.T. (Eur. J. Haematol. 2009) 3 22 46 64
  5. [Association of immune system gene polymorphisms with quantitative features which are pathogenetically important in chronic viral hepatitis]. (PMID: 18610832) Goncharova I.A. … pyzurev V.P. (Mol. Biol. (Mosk.) 2008) 3 22 46 64

Products for IL4 Gene

Sources for IL4 Gene

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