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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL4 Gene

protein-coding   GIFtS: 69
GCID: GC05P132009

Interleukin 4

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 41 2     BSF12
Lymphocyte Stimulatory Factor 11 2 3     binetrakin2
B Cell Growth Factor 11 2     interleukin-42
B_cell Stimulatory Factor 11 2     pitrakinra2
BSF-12 3     Binetrakin3
IL-42 3     Pitrakinra3
BCGF-12     B-Cell Stimulatory Factor 13
BCGF12     

External Ids:    HGNC: 60141   Entrez Gene: 35652   Ensembl: ENSG000001135207   OMIM: 1477805   UniProtKB: P051123   

Export aliases for IL4 gene to outside databases

Previous GC identifers: GC05P131531 GC05P132456 GC05P132041 GC05P132085 GC05P132037 GC05P127201


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL4 Gene:
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a
ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many
overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has
been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3,
IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13.
This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an
over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding
distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL4 Gene: 
IL4 (interleukin 4) is a protein-coding gene. Diseases associated with IL4 include vernal conjunctivitis, and transient acantholytic dermatosis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Allograft rejection. GO annotations related to this gene include growth factor activity and interleukin-4 receptor binding.

UniProtKB/Swiss-Prot: IL4_HUMAN, P05112
Function: Participates in at least several B-cell activation processes as well as of other cell types. It is a
costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It
enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low
affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes

Gene Wiki entry for IL4 (Interleukin 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL4 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q23-q31

IL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P132009:  view genomic region     (about GC identifiers)

Start:
132,009,373 bp from pter      End:
132,018,368 bp from pter
Size:
8,996 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL4_HUMAN, P05112 (See protein sequence)
Recommended Name: Interleukin-4 precursor  
Size: 153 amino acids; 17492 Da
Subcellular location: Secreted
6/25 PDB 3D structures from and Proteopedia for IL4 (see all 25):
1BBN (3D)        1BCN (3D)        1CYL (3D)        1HIJ (3D)        1HIK (3D)        1HZI (3D)    
Secondary accessions: Q14630
Alternative splicing: 2 isoforms:  P05112-1   P05112-2   

Explore the universe of human proteins at neXtProt for IL4: NX_P05112

Explore proteomics data for IL4 at MOPED 

IL4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IL4 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_000580.1  NP_758858.1  

ENSEMBL proteins: 
 ENSP00000231449   ENSP00000325190  

Human Recombinant Protein Products for IL4: 
EMD Millipore Purified and/or Recombinant IL4 Protein
R&D Systems Recombinant & Natural Proteins for IL4 (IL-4)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for IL4
OriGene Protein Over-expression Lysate for IL4
OriGene MassSpec for IL4 
OriGene Custom Protein Services for IL4
GenScript Purified and Recombinant Proteins for IL4
Novus Biologicals IL4 Proteins
Novus Biologicals IL4 Lysate
Sino Biological Recombinant Protein for IL4
Sino Biological Cell Lysate for IL4 
ProSpec Recombinant Protein for IL4
Cloud-Clone Corp. Proteins for IL4 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space TAS11418631
GO:0009897external side of plasma membrane IEA--

IL4 for ontologies           About GeneDecksing



IL4 Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of IL4
R&D Systems Antibodies for IL4 (IL-4)
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ThermoFisher Antibody for IL4
LSBio Antibodies in human, mouse, rat for IL4 

Assay Products for IL4: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IL4
R&D Systems Flow Cytometry Kits for IL4 (IL-4)         (see all)
GenScript Custom Assay Services for IL4
Enzo Life Sciences assays for IL4
Cloud-Clone Corp. ELISAs for IL4 
Cloud-Clone Corp. CLIAs for IL4


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IL: Interleukins and interleukin receptors

5 InterPro protein domains:
 IPR012351 4_helix_cytokine_core
 IPR002354 Interleukin-4
 IPR009079 4_helix_cytokine-like_core
 IPR001325 Interleukin-4/13
 IPR018096 Interleukin-4/-13_CS

Graphical View of Domain Structure for InterPro Entry P05112

ProtoNet protein and cluster: P05112

1 Blocks protein domain: IPB001325 Interleukin-4/interleukin-13

UniProtKB/Swiss-Prot: IL4_HUMAN, P05112
Similarity: Belongs to the IL-4/IL-13 family


IL4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL4_HUMAN, P05112
Function: Participates in at least several B-cell activation processes as well as of other cell types. It is a
costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It
enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low
affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes

     Genatlas biochemistry entry for IL4:
interleukin 4,15kDa,B-cell stimulating factor 1,important switch factor directing Ig-E synthesis

     Summary:
During embryonic development, IL4 as signaling molecule is secreted from the following cells: Multinuclear Myocytes in Lumbar Back Muscles, Multinuclear Myocytes in Cervical Back Muscles (see all 14).

It affects the following cells: Mononuclear Myocytes in Lumbar Primary Epaxial Myotome, Mononuclear Myocytes in Sacral Epaxial Myotome (see all 20).

IL4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Immature dendritic-like cells from Blood, Dendritic-like cells from Blood (see all 20).

     Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0005126cytokine receptor binding ----
GO:0005136interleukin-4 receptor binding TAS11418631
GO:0005515protein binding IPI10219247
GO:0008083growth factor activity NAS11418631
     
IL4 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for IL4:
 Synthetic lethal with imatinib 

     15/19 MGI mutant phenotypes (inferred from 16 alleles(MGI details for Il4) (see all 19):
 cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland  growth/size 
 hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
 mortality/aging  nervous system  no phenotypic analysis  normal  renal/urinary system 

IL4 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for IL4: Il4tm1Rao Il4tm1Nnt Il4tm2Nnt Il4/Il13Il4/tm3Anjm Il4tm1Kopf Il4tm2Rao
                                                     Il4tm1Cgn

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IL4 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL4 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL4 

miRNA
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hsa-miR-340 hsa-miR-410
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for IL4
Sirion Biotech Customized adenovirus for overexpression of IL4

Clone
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OriGene clones in human, mouse for IL4 (see all 9)
OriGene ORF clones in mouse, rat for IL4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): IL4 (NM_000589)
Sino Biological Human cDNA Clone for IL4
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL4
Sirion Biotech Customized lentivirus for stable overexpression of IL4 
                     Customized lentivirus expression plasmids for stable overexpression of IL4 

Cell Line
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GenScript Custom overexpressing Cell Line Services for IL4
Search LifeMap BioReagents cell lines for IL4
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL4


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IL4 About   (see all 36)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Regulation of Innate Immune Cells0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2Allograft rejection
Allograft rejection0.69
Intestinal immune network for IgA production0.42
Autoimmune thyroid disease0.62
THC Differentiation Pathway0.37
Asthma0.47
3Immune response Fc epsilon RI pathway
Fc epsilon RI signaling pathway0.40
Immune response CD16 signaling in NK cells0.32
Immune response IL-4 signaling pathway0.38
4Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
Immune response TLR signaling pathways0.94
5TGF-Beta Pathway
TGF-Beta Pathway0.60
Regulation of eIF4 and p70S6K0.43
MAPK Family Pathway0.60
SOCS Pathway0.40
JAK-STAT Pathway0.57

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

4 EMD Millipore Pathways for IL4
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
Immune response CD16 signaling in NK cells
Selected targets of GCR-alpha
Immune response IL-4 signaling pathway

4 R&D Systems Pathways for IL4
    IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types
IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
IL-4 Signaling Pathways
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/30 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL4 (see all 30)
    THC Differentiation Pathway
Endothelin-1 Signaling Pathway
IL-4 Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C

2 Cell Signaling Technology (CST) Pathways for IL4
    Lymphocyte Signaling
Jak/Stat Pathway

3 GeneGo (Thomson Reuters) Pathways for IL4
    Immune response IL-4 signaling pathway
Immune response CD16 signaling in NK cells
Immune response TLR signaling pathways

5/12 BioSystems Pathways for IL4 (see all 12)
    Cytokines and Inflammatory Response
Spinal Cord Injury
IL-4 signaling Pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Glucocorticoid receptor regulatory network



5/13         Kegg Pathways  (Kegg details for IL4) (see all 13):
    Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
T cell receptor signaling pathway


IL4 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/57 Interacting proteins for IL4 (P051121, 2, 3 ENSP000002314494) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
InteractantInteraction Details
GeneCardExternal ID(s)
IL13RA1P785521, 3, ENSP000003607304EBI-367025,EBI-1391535 I2D: score=1 STRING: ENSP00000360730
IL4RP243941, 2, 3, ENSP000001706304EBI-367025,EBI-367009 MINT-24865 I2D: score=6 STRING: ENSP00000170630
IL13RA2Q146273, ENSP000002432134I2D: score=1 STRING: ENSP00000243213
A2MP010233, ENSP000003239294I2D: score=2 STRING: ENSP00000323929
CD53P193973, ENSP000002713244I2D: score=1 STRING: ENSP00000271324
About this table

Gene Ontology (GO): 5/53 biological process terms (GO ID links to tree view) (see all 53):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002227innate immune response in mucosa IEA--
GO:0002296T-helper 1 cell lineage commitment IEA--
GO:0002674negative regulation of acute inflammatory response IEA--
GO:0002677negative regulation of chronic inflammatory response IEA--
GO:0006935chemotaxis TAS10725748

IL4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL4 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Enzo Life Sciences drugs & compounds for IL4

Browse Tocris compounds for IL4

10/119 Novoseek inferred chemical compound relationships for IL4 gene (see all 119)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
il 10 79.6 147 11166831 (5), 9800291 (4), 12944981 (3), 9624608 (3) (see all 99)
ionomycin 79.1 188 7751024 (6), 8599837 (5), 9158101 (3), 9876227 (3) (see all 99)
rantes 78.9 232 9644628 (5), 11106947 (5), 11385231 (4), 10975998 (4) (see all 99)
allergens 72.6 73 9252871 (3), 8039807 (2), 8612204 (2), 9863362 (2) (see all 57)
tarc 72.5 79 12871855 (5), 12441140 (4), 16810739 (4), 16102259 (4) (see all 35)
alpha-galactosylceramide 72.4 30 16447760 (2), 16027139 (2), 12902477 (1), 14768039 (1) (see all 26)
il-12 64.7 28 14503949 (2), 19398128 (2), 18610832 (2), 15688366 (2) (see all 21)
pge2 62.4 383 9870076 (6), 1845802 (5), 8385653 (5), 9683262 (5) (see all 99)
histamine 62.2 318 8670730 (7), 1372188 (5), 8859220 (5), 8644511 (5) (see all 99)
gm-csf 54.9 24 18166231 (3), 8431518 (2), 10785263 (2), 1751202 (2) (see all 15)

1 PharmGKB related drug/compound annotation for IL4 gene    About this table
Drug/compound PharmGKB Annotation
aspirinCA  

Search CenterWatch for drugs/clinical trials and news about IL4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL4 gene (2 alternative transcripts): 
NM_000589.3  NM_172348.2  

Unigene Cluster for IL4:

Interleukin 4
Hs.73917  [show with all ESTs]
Unigene Representative Sequence: AK310112
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000231449(uc003kxk.1 uc003kxl.1) ENST00000350025 ENST00000495905

Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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2 QIAGEN miScript miRNA Assays for microRNAs that regulate IL4:
hsa-miR-340 hsa-miR-410
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL4
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): IL4 (NM_000589)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL4
Sirion Biotech Customized lentivirus for stable overexpression of IL4 
                     Customized lentivirus expression plasmids for stable overexpression of IL4 
Primer
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OriGene qPCR primer pairs and template standards for IL4
OriGene qSTAR qPCR primer pairs in human, mouse for IL4
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL4
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL4

Additional mRNA sequence: 

AB102862.1 AF043336.1 AK310112.1 AM937235.1 BC066277.1 BC066278.1 BC067514.1 BC067515.1 
BC070123.1 EF173851.1 M13982.1 X81851.1 

2 DOTS entries:

DT.101971469  DT.406716 

22 AceView cDNA sequences:

X81851 NM_172348 BC067514 NM_000589 CD559677 CD559527 AF043336 BC070123 
BC066277 BC066278 CD559676 BC067515 CD640452 M13982 CD559523 CD559524 
T29166 CD559526 CD559525 AW953230 CD521402 CK130262 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for IL4    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:                              
SP2:              -               


ECgene alternative splicing isoforms for IL4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL4 expression in normal human tissues (normalized intensities)      IL4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGAGAGAAAT
IL4 Expression
About this image


IL4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/7 selected tissues (see all 7) fully expand
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 14 entries
         Multinuclear Myocytes Lumbar Back Muscles
 
 Limb (Muscoskeletal System)    fully expand to see all 4 entries
         Multinuclear Myocytes Forelimb Dorsal Muscles
 
 Blood (Hematopoietic System)    fully expand to see all 2 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
         Bone marrow-derived hematopoietic stem cells
 
 Bone (Muscoskeletal System)
         Bone marrow-derived mesenchymal stem cells (Stempeucel)
 
 Adipose (Muscoskeletal System)
         Adipose-derived stromal vascular fraction and adipocytes (HiQCell)

See IL4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL4

SOURCE GeneReport for Unigene cluster: Hs.73917
    SABiosciences Expression via Pathway-Focused PCR Arrays including IL4 (see all 23): 
          Interferons & Receptors in human mouse rat
          Wound Healing in human mouse rat
          T-cell & B-cell Activation in human mouse rat
          Th17 Response in human mouse rat
          Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

Primer
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OriGene qPCR primer pairs and template standards for IL4
OriGene qSTAR qPCR primer pairs in human, mouse for IL4
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL4
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL4
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for IL4 gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il41 , 5 interleukin 41, 5 57.79(n)1
44.6(a)1
  11 (31.97 cM)5
161891  NM_021283.21  NP_067258.11 
 536029825 


ENSEMBL Gene Tree for IL4 (if available)
TreeFam Gene Tree for IL4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/383 SNPs in IL4 are shown (see all 383)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs341423201,2
C--132007975(+) GGGGG-/GCGGGG 2 -- us2k12Minor allele frequency- G:0.25NA CSA 4
rs341854421,2
C--132008994(+) AAAAA-/AGTCAT 2 -- us2k11Minor allele frequency- A:0.00NA 2
rs3694300531,2
C--132011244(+) ACACA-/TTTTTT 2 -- int10--------
rs1502335161,2
C--132011621(+) GTATA-/TGTG/TGTG
TGTGTGTGTGTG
TGTGT
2 -- int10--------
rs673380031,2
C--132011641(-) ACACA-/ACACA 
CAC
/CACA
CACAC
2 -- int11NA 2
rs22432691,2
C,F--132014012(+) TATGT-/AAAGAGT 2 -- int18Minor allele frequency- AA:0.14NS MN CSA 488
rs22432391,2
C,F--132284584(+) GGATCA/GTTTTG 2 -- us2k13Minor allele frequency- G:0.03NS WA 210
rs1918388991,2
--132284687(+) GGCATA/GTGCCT 2 -- us2k10--------
rs1829358091,2
--132284708(+) CTACTC/TGGGAA 2 -- us2k10--------
rs727973961,2
C,F--132284759(+) TACAGT/AAAGCT 2 -- us2k11Minor allele frequency- A:0.08NA 120

HapMap Linkage Disequilibrium report for IL4 (132009373 - 132018368 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/11 variations for IL4 (see all 11):    About this table     
Variant IDTypeSubtypePubMed ID
esv2730793CNV Deletion23290073
esv2348204CNV Deletion18987734
dgv28e197CNV Deletion19546169
esv2730791CNV Deletion23290073
esv2730792CNV Deletion23290073
dgv6334n71CNV Loss21882294
dgv6335n71CNV Loss21882294
dgv6333n71CNV Loss21882294
nsv529021CNV Loss19592680
nsv882918CNV Loss21882294


Human Gene Mutation Database (HGMD): IL4
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IL4
DNA2.0 Custom Variant and Variant Library Synthesis for IL4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 147780    OMIM disorders: --

UniProtKB/Swiss-Prot: IL4_HUMAN, P05112
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural
    tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes,
    resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of
    heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • 20/367 diseases for IL4 (see all 367):    About MalaCards
    vernal conjunctivitis    transient acantholytic dermatosis    conjunctival disease    leishmaniasis
    allergic conjunctivitis    cough variant asthma    multifocal motor neuropathy    chromoblastomycosis
    trichinosis    atopic keratoconjunctivitis    toxic oil syndrome    angiostrongyliasis
    egg allergy    eosinophilic meningitis    pleural tuberculosis    intrinsic asthma
    hyper ige syndrome    schistosomiasis    aspergillosis    keratoconjunctivitis

    15 diseases from the University of Copenhagen DISEASES database for IL4:
    Asthma     Atopic dermatitis     Hypersensitivity reaction type I disease     Eosinophilia
    Allergic rhinitis     Leishmaniasis     Hypersensitivity reaction type II disease     Arthritis
    Leukemia     Lymphoma     Connective tissue disease     Tuberculosis
    Schistosomiasis     Tetanus     Multiple sclerosis

    IL4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/97 Novoseek inferred disease relationships for IL4 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 86.4 2094 2032220 (3), 9127126 (3), 10768979 (3), 7622234 (3) (see all 99)
    dermatitis atopic 81.8 229 15014952 (6), 11678851 (5), 1685830 (4), 8082305 (4) (see all 99)
    asthma allergic 79.5 127 10810222 (4), 8250351 (3), 8534490 (3), 8902881 (3) (see all 77)
    asthma 79.5 651 10336593 (5), 11991881 (5), 7648458 (5), 19910025 (5) (see all 99)
    inflammation 78.7 397 8809430 (4), 18576346 (3), 8376806 (2), 7673736 (2) (see all 99)
    allergy 73.7 145 12363420 (3), 10460779 (2), 18031948 (2), 8908280 (2) (see all 99)
    tumors 73.5 2022 9816099 (7), 20003817 (6), 8423237 (5), 8280717 (5) (see all 99)
    atopy 73.4 122 10753021 (3), 15087090 (3), 12911786 (3), 11990231 (2) (see all 85)
    severe combined immunodeficiency, x-linked 71.7 48 8557662 (3), 7937790 (2), 8026467 (1), 7803808 (1) (see all 32)
    eosinophilia 70.7 114 11776778 (2), 12789240 (2), 14768039 (2), 10592468 (2) (see all 77)

    Genetic Association Database (GAD): IL4
    Human Genome Epidemiology (HuGE) Navigator: IL4 (493 documents)
    Tumor Gene Database (TGDB): IL4

    Export disorders for IL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL4 gene, integrated from 9 sources (see all 5404):
    (articles sorted by number of sources associating them with IL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis. (PubMed id 14681304)1, 2, 4 Zee R.Y.L.... Ridker P.M. (2004)
    2. Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B- cell- and T-cell-stimulating activities. (PubMed id 3016727)1, 2, 3 Yokota T.... Arai K. (1986)
    3. Relative levels of IL4 and IFN-gamma in complicated malaria: association with IL4 polymorphism and peripheral parasitemia. (PubMed id 17379175)1, 4, 9 Tangteerawatana P....Khusmith S. (2007)
    4. Association of interleukin (IL)-4 intron-3 and IL-6 -174 G/C gene polymorphism with susceptibility to end-stage renal disease. (PubMed id 17203290)1, 4, 9 Mittal R.D. and Manchanda P.K. (2007)
    5. Association between the polymorphisms of IL-4 gene promoter (-590C>T), IL-13 coding region (R130Q) and IL-16 gene promoter (-295T>C) and allergic asthma. (PubMed id 17303923)1, 4, 9 Hosseini-Farahabadi S....Khaje Daluei M. (2007)
    6. [Correlation between polymorphism of IL-4 and IL-10 gene promoter and childhood asthma and their impact upon cytokine expression] (PubMed id 11953141)1, 4, 9 Zhang J....Chen Y. (2002)
    7. Sequencing the IL4 locus in African Americans implica tes rare noncoding variants in asthma susceptibility. (PubMed id 19910025)1, 4, 9 Haller G....Thompson E.E. (2009)
    8. Interleukin-4 (C-590T) and interferon-gamma (G5644A) gene polymorphisms in patients with periodontitis. (PubMed id 18230112)1, 4, 9 Hooshmand B....Ghasemi R. (2008)
    9. Interleukin-4 C-590T polymorphism is associated with protection against nasal polyps in a Korean population. (PubMed id 17063753)1, 4, 9 Yea S.S....Chun J.H. (2006)
    10. Epistatic effect of TLR4 and IL4 genes on the risk of asthma in females. (PubMed id 16215326)1, 4, 9 Adjers K....Hurme M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3565 HGNC: 6014 AceView: IL4 Ensembl:ENSG00000113520 euGenes: HUgn3565
    ECgene: IL4 Kegg: 3565 H-InvDB: IL4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL4 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/il4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL4 gene:
    Search GeneIP for patents involving IL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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