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IL4 Gene

protein-coding   GIFtS: 70
GCID: GC05P132009

Interleukin 4

  See IL4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 41 2     BSF12
Lymphocyte Stimulatory Factor 11 2 3     binetrakin2
B Cell Growth Factor 11 2     Interleukin 4 Variant 22
B_cell Stimulatory Factor 11 2     interleukin-42
BSF-12 3     pitrakinra2
IL-42 3     Binetrakin3
BCGF-12     Pitrakinra3
BCGF12     B-Cell Stimulatory Factor 13

External Ids:    HGNC: 60141   Entrez Gene: 35652   Ensembl: ENSG000001135207   OMIM: 1477805   UniProtKB: P051123   

Export aliases for IL4 gene to outside databases

Previous GC identifers: GC05P131531 GC05P132456 GC05P132041 GC05P132085 GC05P132037 GC05P127201


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL4 Gene:
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a
ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many
overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has
been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3,
IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13.
This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an
over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding
distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL4 Gene:
IL4 (interleukin 4) is a protein-coding gene. Diseases associated with IL4 include transient acantholytic dermatosis, and vernal conjunctivitis. GO annotations related to this gene include interleukin-4 receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IL4_HUMAN, P05112
Function: Participates in at least several B-cell activation processes as well as of other cell types. It is a
costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It
enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low
affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes

Gene Wiki entry for IL4 (Interleukin 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL4 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL4 promoter sequence
   Search Chromatin IP Primers for IL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q23-q31

IL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P132009:  view genomic region     (about GC identifiers)

Start:
132,009,373 bp from pter      End:
132,018,368 bp from pter
Size:
8,996 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL4_HUMAN, P05112 (See protein sequence)
Recommended Name: Interleukin-4 precursor  
Size: 153 amino acids; 17492 Da
Selected PDB 3D structures from and Proteopedia for IL4 (see all 25):
1BBN (3D)        1BCN (3D)        1CYL (3D)        1HIJ (3D)        1HIK (3D)        1HZI (3D)    
Secondary accessions: Q14630 Q6NZ77
Alternative splicing: 2 isoforms:  P05112-1   P05112-2   

Explore the universe of human proteins at neXtProt for IL4: NX_P05112

Explore proteomics data for IL4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn62

  • See IL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000580.1  NP_758858.1  

    ENSEMBL proteins: 
     ENSP00000231449   ENSP00000325190  

    IL4 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IL4 Protein
    R&D Systems Recombinant & Natural Proteins for IL4 (IL-4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IL4
    OriGene Protein Over-expression Lysate for IL4
    OriGene MassSpec for IL4
    OriGene Custom Protein Services for IL4
    GenScript Purified and Recombinant Proteins for IL4
    Novus Biologicals IL4 Proteins
    Novus Biologicals IL4 Lysate
    Sino Biological Recombinant Protein for IL4
    Sino Biological Cell Lysate for IL4
    ProSpec Recombinant Protein for IL4
    Cloud-Clone Corp. Proteins for IL4

     
    eBioscience Proteins for IL4: (see all 4
                        Human IL-4 Single-Use ELISA RSG Standard 4 pack

    IL4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL4
    R&D Systems Antibodies for IL4 (IL-4)
    Cell Signaling Technology (CST) Antibodies for IL4 
    OriGene Antibodies for IL4
    OriGene Custom Antibody Services for IL4
    Novus Biologicals IL4 Antibodies
    Abcam antibodies for IL4
    Cloud-Clone Corp. Antibodies for IL4
    ThermoFisher Antibody for IL4
    LSBio Antibodies in human, mouse, rat for IL4

    IL4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL4
    R&D Systems Flow Cytometry Kits for IL4 (IL-4)         (see all)
    GenScript Custom Assay Services for IL4
    Enzo Life Sciences assays for IL4
    Cloud-Clone Corp. ELISAs for IL4
    Cloud-Clone Corp. CLIAs for IL4
    eBioscience ELISAs for IL4: (see all 7
                        Human IL-4 Instant ELISA 128 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    5 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR002354 IL-4
     IPR009079 4_helix_cytokine-like_core
     IPR001325 IL-4/IL-13
     IPR018096 IL-4/IL-13_CS

    Graphical View of Domain Structure for InterPro Entry P05112

    ProtoNet protein and cluster: P05112

    1 Blocks protein domain: IPB001325 Interleukin-4/interleukin-13

    UniProtKB/Swiss-Prot: IL4_HUMAN, P05112
    Similarity: Belongs to the IL-4/IL-13 family


    Find genes that share domains with IL4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL4_HUMAN, P05112
    Function: Participates in at least several B-cell activation processes as well as of other cell types. It is a
    costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It
    enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low
    affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes

         Genatlas biochemistry entry for IL4:
    interleukin 4,15kDa,B-cell stimulating factor 1,important switch factor directing Ig-E synthesis

         Summary: 
    During embryonic development, IL4 as signaling molecule is secreted from the following cells:
                fully expand
    Skeletal Muscle: Multinuclear Myocytes (Sacral Back Muscles), Multinuclear Myocytes (Thoracic Vertebral Colomn Muscles)      fully expand to see all 10 cells
    Limb: Multinuclear Myocytes (Hindlimb Ventral Muscle), Multinuclear Myocytes (Forelimb Ventral Muscles)      fully expand to see all 4 cells

    It affects the following cells:       fully expand
    Somite: Mononuclear Myocytes (Sacral Hypaxial Myotome), Mononuclear Myocytes (Cervical Primary Epaxial Myotome)      fully expand to see all 16 cells
    Limb: Mononuclear Myocytes (Hindlimb Ventral Muscle), Mononuclear Myocytes (Forelimb Dorsal Muscles)      fully expand to see all 4 cells

    IL4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                
    Blood: Dendritic-like cells, Immature dendritic-like cells       to see all 2 cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005126cytokine receptor binding ----
    GO:0005136interleukin-4 receptor binding TAS11418631
    GO:0005515protein binding IPI10219247
    GO:0008083growth factor activity NAS11418631
         
    Find genes that share ontologies with IL4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IL4:
     Synthetic lethal with imatinib 

         Selected MGI mutant phenotypes (inferred from 16 alleles(MGI details for Il4) (see all 19):
     cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  nervous system  no phenotypic analysis  normal  renal/urinary system 

    Find genes that share phenotypes with IL4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL4: Il4tm1Rao Il4tm1Nnt Il4tm2Nnt Il4/Il13Il4/tm3Anjm Il4tm2Rao Il4tm1Kopf
                                                         Il4tm1Cgn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL4

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL4:
    hsa-mir-335-5p (MIRT018167)

    Block miRNA regulation of human, mouse, rat IL4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate IL4:
    hsa-miR-340 hsa-miR-410
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL4
    Predesigned siRNA for gene silencing in human, mouse, rat IL4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL4

    Clone
    Products:
         
    OriGene clones in human, mouse for IL4 (see all 9)
    OriGene ORF clones in mouse, rat for IL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IL4 (NM_000589)
    Sino Biological Human cDNA Clone for IL4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL4
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL4

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11301 VF1-14269) for IL4 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL4_HUMAN, P05112: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane2
    cytoskeleton1
    cytosol1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space TAS11418631
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with IL4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL4 About   (see all 38)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Allograft rejection
    Allograft rejection0.86
    Asthma0.46
    Allograft Rejection0.86
    Intestinal immune network for IgA production0.41
    Autoimmune thyroid disease0.61
    THC Differentiation Pathway0.38
    2PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61


    Find genes that share SuperPaths with IL4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 R&D Systems Pathways for IL4
        IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-4 Signaling Pathways
    IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL4 (see all 30)
        THC Differentiation Pathway
    Endothelin-1 Signaling Pathway
    IL-4 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    2 Cell Signaling Technology (CST) Pathways for IL4
        Lymphocyte Signaling
    Jak/Stat Pathway

    3 GeneGo (Thomson Reuters) Pathways for IL4
        Immune response IL-4 signaling pathway
    Immune response CD16 signaling in NK cells
    Immune response TLR signaling pathways

    Selected BioSystems Pathways for IL4 (see all 13)
        Cytokines and Inflammatory Response
    Spinal Cord Injury
    Allograft Rejection
    IL-4 signaling Pathway
    IL4-mediated signaling events



    Selected Kegg Pathways  (Kegg details for IL4) (see all 13):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway
    Hematopoietic cell lineage
    T cell receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL4 (see all 23): 
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Th17 Response in human mouse rat
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL4 (P051121, 2, 3 ENSP000002314494) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL13RA1P785521, 3, ENSP000003607304EBI-367025,EBI-1391535 I2D: score=1 STRING: ENSP00000360730
    IL4RP243941, 2, 3, ENSP000001706304EBI-367025,EBI-367009 MINT-24865 I2D: score=6 STRING: ENSP00000170630
    IL13RA2Q146273, ENSP000002432134I2D: score=1 STRING: ENSP00000243213
    A2MP010233, ENSP000003239294I2D: score=2 STRING: ENSP00000323929
    CD53P193973, ENSP000002713244I2D: score=1 STRING: ENSP00000271324
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 56):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0002227innate immune response in mucosa IEA--
    GO:0002296T-helper 1 cell lineage commitment IEA--
    GO:0002674negative regulation of acute inflammatory response IEA--
    GO:0002677negative regulation of chronic inflammatory response IEA--

    Find genes that share ontologies with IL4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for IL4
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL4

    Selected Novoseek inferred chemical compound relationships for IL4 gene (see all 119)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    il 10 79.6 147 11166831 (5), 9800291 (4), 12944981 (3), 9624608 (3) (see all 99)
    ionomycin 79.1 188 7751024 (6), 8599837 (5), 9158101 (3), 9876227 (3) (see all 99)
    rantes 78.9 232 9644628 (5), 11106947 (5), 11385231 (4), 10975998 (4) (see all 99)
    allergens 72.6 73 9252871 (3), 8039807 (2), 8612204 (2), 9863362 (2) (see all 57)
    tarc 72.5 79 12871855 (5), 12441140 (4), 16810739 (4), 16102259 (4) (see all 35)
    alpha-galactosylceramide 72.4 30 16447760 (2), 16027139 (2), 12902477 (1), 14768039 (1) (see all 26)
    il-12 64.7 28 14503949 (2), 19398128 (2), 18610832 (2), 15688366 (2) (see all 21)
    pge2 62.4 383 9870076 (6), 1845802 (5), 8385653 (5), 9683262 (5) (see all 99)
    histamine 62.2 318 8670730 (7), 1372188 (5), 8859220 (5), 8644511 (5) (see all 99)
    gm-csf 54.9 24 18166231 (3), 8431518 (2), 10785263 (2), 1751202 (2) (see all 15)

    1 PharmGKB related drug/compound annotation for IL4 gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  



    Find genes that share compounds with IL4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL4 gene (2 alternative transcripts): 
    NM_000589.3  NM_172348.2  

    Unigene Cluster for IL4:

    Interleukin 4
    Hs.73917  [show with all ESTs]
    Unigene Representative Sequence: AK310112
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000231449(uc003kxk.1 uc003kxl.1) ENST00000350025 ENST00000495905

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IL4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate IL4:
    hsa-miR-340 hsa-miR-410
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IL4
    Predesigned siRNA for gene silencing in human, mouse, rat IL4
    Clone
    Products:
         
    OriGene clones in human, mouse for IL4 (see all 9)
    OriGene ORF clones in mouse, rat for IL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IL4 (NM_000589)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL4
    OriGene qSTAR qPCR primer pairs in human, mouse for IL4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL4
      QuantiTect SYBR Green Assays in human, mouse, rat IL4
      QuantiFast Probe-based Assays in human, mouse, rat IL4
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11301 VF1-14269) for IL4 

    Additional mRNA sequence: 

    AB102862.1 AF043336.1 AK310112.1 AM937235.1 BC066277.1 BC066278.1 BC067514.1 BC067515.1 
    BC070123.1 EF173851.1 M13982.1 X81851.1 

    2 DOTS entries:

    DT.101971469  DT.406716 

    22 AceView cDNA sequences:

    NM_000589 BC067514 NM_172348 X81851 CD559677 M13982 BC066277 CD640452 
    CD559527 BC070123 BC066278 CD559676 AF043336 BC067515 CD559523 CD559525 
    T29166 CD559526 CD559524 AW953230 CD521402 CK130262 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for IL4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for IL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGAGAAAT
    IL4 Expression
    About this image


    IL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 14 entries
             Multinuclear Myocytes Lumbar Back Muscles
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Bone marrow-derived hematopoietic stem cells
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells (family)
    IL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73917
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL4 (see all 23): 
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Th17 Response in human mouse rat
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL4 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il41 , 5 interleukin 41, 5 57.79(n)1
    44.6(a)1
      11 (31.97 cM)5
    161891  NM_021283.21  NP_067258.11 
     536029825 


    ENSEMBL Gene Tree for IL4 (if available)
    TreeFam Gene Tree for IL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL4 (see all 383)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs341423201,2
    C--132007975(+) GGGGG-/GCGGGG 2 -- us2k12Minor allele frequency- G:0.25NA CSA 4
    rs341854421,2
    C--132008994(+) AAAAA-/AGTCAT 2 -- us2k11Minor allele frequency- A:0.00NA 2
    rs3694300531,2
    C--132011244(+) ACACA-/TTTTTT 2 -- int10--------
    rs1502335161,2
    C--132011621(+) GTATA-/TGTG/TGTG
    TGTGTGTGTGTG
    TGTGT
    2 -- int10--------
    rs673380031,2
    C--132011641(-) ACACA-/ACACA 
    CAC
    /CACA
    CACAC
    2 -- int11NA 2
    rs22432691,2
    C,F--132014012(+) TATGT-/AAAGAGT 2 -- int18Minor allele frequency- AA:0.14NS MN CSA 488
    rs22432391,2
    C,F--132284584(+) GGATCA/GTTTTG 2 -- us2k13Minor allele frequency- G:0.03NS WA 210
    rs1918388991,2
    --132284687(+) GGCATA/GTGCCT 2 -- us2k10--------
    rs1829358091,2
    --132284708(+) CTACTC/TGGGAA 2 -- us2k10--------
    rs727973961,2
    C,F--132284759(+) TACAGT/AAAGCT 2 -- us2k11Minor allele frequency- A:0.08NA 120

    HapMap Linkage Disequilibrium report for IL4 (132009373 - 132018368 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IL4 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730793CNV Deletion23290073
    esv2348204CNV Deletion18987734
    dgv28e197CNV Deletion19546169
    esv2730791CNV Deletion23290073
    esv2730792CNV Deletion23290073
    dgv6334n71CNV Loss21882294
    dgv6335n71CNV Loss21882294
    dgv6333n71CNV Loss21882294
    nsv529021CNV Loss19592680
    nsv882918CNV Loss21882294

    Human Gene Mutation Database (HGMD): IL4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL4
    DNA2.0 Custom Variant and Variant Library Synthesis for IL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147780    OMIM disorders: --

    UniProtKB/Swiss-Prot: IL4_HUMAN, P05112
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural
    tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes,
    resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of
    heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • Selected diseases for IL4 (see all 54):    
    About MalaCards
    transient acantholytic dermatosis    vernal conjunctivitis    blepharoconjunctivitis    conjunctival disease
    leishmaniasis    keratoconjunctivitis    kimura disease    conjunctivitis
    intrinsic asthma    toxic oil syndrome    cough variant asthma    pleural tuberculosis
    angiostrongyliasis    chromoblastomycosis    scleritis    multidrug-resistant tuberculosis
    hyper ige syndrome    eosinophilic meningitis    abacavir hypersensitivity    atopic keratoconjunctivitis

    15 diseases from the University of Copenhagen DISEASES database for IL4:
    Asthma     Atopic dermatitis     Hypersensitivity reaction type I disease     Eosinophilia
    Allergic rhinitis     Leishmaniasis     Hypersensitivity reaction type II disease     Arthritis
    Leukemia     Lymphoma     Connective tissue disease     Tuberculosis
    Schistosomiasis     Tetanus     Multiple sclerosis

    Find genes that share disorders with IL4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL4 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 86.4 2094 2032220 (3), 9127126 (3), 10768979 (3), 7622234 (3) (see all 99)
    dermatitis atopic 81.8 229 15014952 (6), 11678851 (5), 1685830 (4), 8082305 (4) (see all 99)
    asthma allergic 79.5 127 10810222 (4), 8250351 (3), 8534490 (3), 8902881 (3) (see all 77)
    asthma 79.5 651 10336593 (5), 11991881 (5), 7648458 (5), 19910025 (5) (see all 99)
    inflammation 78.7 397 8809430 (4), 18576346 (3), 8376806 (2), 7673736 (2) (see all 99)
    allergy 73.7 145 12363420 (3), 10460779 (2), 18031948 (2), 8908280 (2) (see all 99)
    tumors 73.5 2022 9816099 (7), 20003817 (6), 8423237 (5), 8280717 (5) (see all 99)
    atopy 73.4 122 10753021 (3), 15087090 (3), 12911786 (3), 11990231 (2) (see all 85)
    severe combined immunodeficiency, x-linked 71.7 48 8557662 (3), 7937790 (2), 8026467 (1), 7803808 (1) (see all 32)
    eosinophilia 70.7 114 11776778 (2), 12789240 (2), 14768039 (2), 10592468 (2) (see all 77)

    Genetic Association Database (GAD): IL4
    Human Genome Epidemiology (HuGE) Navigator: IL4 (493 documents)
    Tumor Gene Database (TGDB): IL4

    Export disorders for IL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL4 gene, integrated from 10 sources (see all 5427):
    (articles sorted by number of sources associating them with IL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis. (PubMed id 14681304)1, 2, 4 Zee R.Y.L.... Ridker P.M. (Hum. Mol. Genet. 2004)
    2. Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B- cell- and T-cell-stimulating activities. (PubMed id 3016727)1, 2, 3 Yokota T.... Arai K. (Proc. Natl. Acad. Sci. U.S.A. 1986)
    3. Relative levels of IL4 and IFN-gamma in complicated malaria: association with IL4 polymorphism and peripheral parasitemia. (PubMed id 17379175)1, 4, 9 Tangteerawatana P....Khusmith S. (Acta Trop. 2007)
    4. Association of interleukin (IL)-4 intron-3 and IL-6 -174 G/C gene polymorphism with susceptibility to end-stage renal disease. (PubMed id 17203290)1, 4, 9 Mittal R.D. and Manchanda P.K. (Immunogenetics 2007)
    5. Association between the polymorphisms of IL-4 gene promoter (-590C&gt;T), IL-13 coding region (R130Q) and IL-16 gene promoter (-295T&gt;C) and allergic asthma. (PubMed id 17303923)1, 4, 9 Hosseini-Farahabadi S....Khaje Daluei M. (Iran J Allergy Asthma Immunol 2007)
    6. [Correlation between polymorphism of IL-4 and IL-10 gene promoter and childhood asthma and their impact upon cytokine expression]. (PubMed id 11953141)1, 4, 9 Zhang J....Chen Y. (Zhonghua Yi Xue Za Zhi 2002)
    7. Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility. (PubMed id 19910025)1, 4, 9 Haller G....Thompson E.E. (J. Allergy Clin. Immunol. 2009)
    8. Interleukin-4 (C-590T) and interferon-gamma (G5644A) gene polymorphisms in patients with periodontitis. (PubMed id 18230112)1, 4, 9 Hooshmand B....Ghasemi R. (J. Periodont. Res. 2008)
    9. Interleukin-4 C-590T polymorphism is associated with protection against nasal polyps in a Korean population. (PubMed id 17063753)1, 4, 9 Yea S.S....Chun J.H. (Am J Rhinol 2006)
    10. Epistatic effect of TLR4 and IL4 genes on the risk of asthma in females. (PubMed id 16215326)1, 4, 9 Adjers K....Hurme M. (Int. Arch. Allergy Immunol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3565 HGNC: 6014 AceView: IL4 Ensembl:ENSG00000113520 euGenes: HUgn3565
    ECgene: IL4 Kegg: 3565 H-InvDB: IL4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL4 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/il4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL4 gene:
    Search GeneIP for patents involving IL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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