Aliases for IL4 Gene
External Ids for IL4 Gene
Previous GeneCards Identifiers for IL4 Gene
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL4 Gene
IL4 (Interleukin 4) is a Protein Coding gene. Diseases associated with IL4 include Allergic Bronchopulmonary Aspergillosis and Food Allergy. Among its related pathways are p70S6K Signaling and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. GO annotations related to this gene include cytokine activity and cytokine receptor binding.
UniProtKB/Swiss-Prot for IL4 Gene
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.