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Aliases for IL4 Gene

Aliases for IL4 Gene

  • Interleukin 4 2 3
  • Lymphocyte Stimulatory Factor 1 2 3 4
  • B_cell Stimulatory Factor 1 2 3
  • B Cell Growth Factor 1 2 3
  • Binetrakin 3 4
  • Pitrakinra 3 4
  • BSF-1 3 4
  • IL-4 3 4
  • B-Cell Stimulatory Factor 1 4
  • Interleukin 4 Variant 2 3
  • Interleukin-4 3
  • BCGF-1 3
  • BCGF1 3
  • BSF1 3

External Ids for IL4 Gene

Summaries for IL4 Gene

Entrez Gene Summary for IL4 Gene

  • The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL4 Gene

IL4 (Interleukin 4) is a Protein Coding gene. Diseases associated with IL4 include transient acantholytic dermatosis and vernal conjunctivitis. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and interleukin-4 receptor binding.

UniProtKB/Swiss-Prot for IL4 Gene

  • Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes

Gene Wiki entry for IL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL4 Gene

Genomics for IL4 Gene

Genomic Location for IL4 Gene

Start:
132,673,986 bp from pter
End:
132,682,678 bp from pter
Size:
8,693 bases
Orientation:
Plus strand

Genomic View for IL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL4 Gene

Regulatory Elements for IL4 Gene

Transcription factor binding sites by QIAGEN in the IL4 gene promoter:

Proteins for IL4 Gene

  • Protein details for IL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05112-IL4_HUMAN
    Recommended name:
    Interleukin-4
    Protein Accession:
    P05112
    Secondary Accessions:
    • Q14630
    • Q6NZ77

    Protein attributes for IL4 Gene

    Size:
    153 amino acids
    Molecular mass:
    17492 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL4 Gene

    Alternative splice isoforms for IL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL4 Gene

Proteomics data for IL4 Gene at MOPED

Post-translational modifications for IL4 Gene

Other Protein References for IL4 Gene

No data available for DME Specific Peptides for IL4 Gene

Domains for IL4 Gene

Gene Families for IL4 Gene

HGNC:
  • IL :Interleukins and interleukin receptors

UniProtKB/Swiss-Prot:

IL4_HUMAN
Family:
  • Belongs to the IL-4/IL-13 family.:
    • P05112
genes like me logo Genes that share domains with IL4: view

Function for IL4 Gene

Molecular function for IL4 Gene

GENATLAS Biochemistry: interleukin 4,15kDa,B-cell stimulating factor 1,important switch factor directing Ig-E synthesis
UniProtKB/Swiss-Prot Function: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes

LifeMap Function Summary for IL4 Gene

It affects the following cells:
IL4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for IL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding --
GO:0005136 interleukin-4 receptor binding TAS 11418631
GO:0005515 protein binding IPI 10219247
GO:0008083 growth factor activity NAS 11418631
genes like me logo Genes that share ontologies with IL4: view
genes like me logo Genes that share phenotypes with IL4: view

Animal Models for IL4 Gene

MGI Knock Outs for IL4:

miRNA for IL4 Gene

miRTarBase miRNAs that target IL4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL4 Gene

Localization for IL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL4 Gene COMPARTMENTS Subcellular localization image for IL4 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
cytoskeleton 1
cytosol 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space TAS 11418631
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with IL4: view

Pathways for IL4 Gene

genes like me logo Genes that share pathways with IL4: view

Gene Ontology (GO) - Biological Process for IL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEA --
GO:0001934 positive regulation of protein phosphorylation --
GO:0002227 innate immune response in mucosa IEA --
GO:0002230 positive regulation of defense response to virus by host IEA --
GO:0002296 T-helper 1 cell lineage commitment IEA --
genes like me logo Genes that share ontologies with IL4: view

Compounds for IL4 Gene

(119) Novoseek inferred chemical compound relationships for IL4 Gene

Compound -log(P) Hits PubMed IDs
il 10 79.6 130
ionomycin 79.1 129
rantes 78.9 143
allergens 72.6 67
tarc 72.5 68

(1) PharmGKB related drug/compound annotations for IL4 Gene

Drug/compound Annotation
aspirin CA
genes like me logo Genes that share compounds with IL4: view

Transcripts for IL4 Gene

mRNA/cDNA for IL4 Gene

Unigene Clusters for IL4 Gene

Interleukin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for IL4 Gene

GeneLoc Exon Structure for
IL4
ECgene alternative splicing isoforms for
IL4

Expression for IL4 Gene

mRNA expression in normal human tissues for IL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL4 Gene

This gene is overexpressed in Pituitary (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL4 Gene

SOURCE GeneReport for Unigene cluster for IL4 Gene Hs.73917

genes like me logo Genes that share expressions with IL4: view

Orthologs for IL4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL4 36
  • 99.78 (n)
  • 99.35 (a)
IL4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL4 36
  • 75.19 (n)
  • 65.41 (a)
IL4 37
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL4 36
  • 72.26 (n)
  • 56.49 (a)
IL4 37
  • 27 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il4 36
  • 57.79 (n)
  • 44.6 (a)
Il4 16
Il4 37
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il4 36
  • 60.91 (n)
  • 45.32 (a)
Species with no ortholog for IL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL4 Gene

ENSEMBL:
Gene Tree for IL4 (if available)
TreeFam:
Gene Tree for IL4 (if available)

Paralogs for IL4 Gene

No data available for Paralogs for IL4 Gene

Variants for IL4 Gene

Sequence variations from dbSNP and Humsavar for IL4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs734244 -- 132,675,034(-) AAGCT(A/G)AGGAG intron-variant
rs2070874 -- 132,674,018(+) AATTG(C/T)CTCAC utr-variant-5-prime, upstream-variant-2KB
rs2079102 -- 132,674,914(-) AATGA(A/C)AGCTC intron-variant
rs2227282 -- 132,677,487(-) TTTTA(C/G)TTGCT intron-variant
rs2227284 -- 132,677,033(-) GAAAT(A/C)GCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL4 Gene

Variant ID Type Subtype PubMed ID
nsv528281 CNV Gain 19592680
dgv6333n71 CNV Loss 21882294
dgv6334n71 CNV Loss 21882294
dgv6335n71 CNV Loss 21882294
dgv28e197 CNV Deletion 19546169
esv2730791 CNV Deletion 23290073
esv2348204 CNV Deletion 18987734
esv2730792 CNV Deletion 23290073
esv2730793 CNV Deletion 23290073
nsv529021 CNV Loss 19592680
nsv882918 CNV Loss 21882294

Relevant External Links for IL4 Gene

HapMap Linkage Disequilibrium report
IL4
Human Gene Mutation Database (HGMD)
IL4

Disorders for IL4 Gene

UniProtKB/Swiss-Prot

IL4_HUMAN
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269 PubMed:14681304}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(97) Novoseek inferred disease relationships for IL4 Gene

Disease -log(P) Hits PubMed IDs
necrosis 86.4 172
dermatitis atopic 81.8 152
asthma allergic 79.5 106
asthma 79.5 253
inflammation 78.7 126

Relevant External Links for IL4

Genetic Association Database (GAD)
IL4
Human Genome Epidemiology (HuGE) Navigator
IL4
Tumor Gene Database (TGDB):
IL4
genes like me logo Genes that share disorders with IL4: view

Publications for IL4 Gene

  1. Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface. (PMID: 10219247) Hage T. … Reinemer P. (Cell 1999) 3 4 23
  2. IL-4 VNTR gene polymorphism in chronic polyarthritis. The rare allele is associated with protection against destruction. (PMID: 11035134) Buchs N. … Miossec P. (Rheumatology (Oxford) 2000) 3 23 49
  3. Cytokine gene polymorphisms in psoriasis. (PMID: 11298547) Craven N.M. … Griffiths C.E. (Br. J. Dermatol. 2001) 3 23 49
  4. The -590C/T and -34C/T interleukin-4 promoter polymorphisms are not associated with atopic eczema in childhood. (PMID: 11496248) Elliott K. … Forrest S. (J. Allergy Clin. Immunol. 2001) 3 23 49
  5. Interleukin-4 and interleukin-4 receptor gene polymorphisms in inflammatory bowel diseases. (PMID: 11528525) Klein W. … Epplen J.T. (Genes Immun. 2001) 3 23 49

Products for IL4 Gene

Sources for IL4 Gene

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