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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL4 Gene

protein-coding GIFtS: 68
GCID: GC05P132009

interleukin 4

Explore 392 diseases affiliated with
IL4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 4¹ ²		B Cell Growth Factor 1²
IL-4¹ ² ³		B_cell Stimulatory Factor 1²
BCGF-1¹ ²		Binetrakin³
BCGF1¹ ²		Interleukin-4¹
BSF1¹ ²		Pitrakinra³
Lymphocyte Stimulatory Factor 1² ³		Binetrakin³
BSF-1² ³		Pitrakinra³
MGC79402¹		B-Cell Stimulatory Factor 1³

External Ids:	HGNC: 6014¹	Entrez Gene: 3565²	Ensembl: ENSG00000113520⁷	OMIM: 147780⁵	UniProtKB: P05112³

Export aliases for IL4 gene to outside databases

Previous GC identifers: GC05P131531 GC05P132456 GC05P132041 GC05P132085 GC05P132037 GC05P127201

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL4:

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for

interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping

functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play

a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a

cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found

to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the

chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL4_HUMAN, P05112

Function: Participates in at least several B-cell activation processes as well as of other cell types. It is a

costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances

both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc

receptor for IgE (CD23) on both lymphocytes and monocytes

Gene Wiki entry for IL4 (Interleukin 4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL4 gene promoter:
AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL4 promoter sequence

Search SABiosciences Chromatin IP Primers for IL4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q23-q31

IL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL4 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P132009: view genomic region (about GC identifiers)

Start:	132,009,373 bp from pter	End:	132,018,368 bp from pter
Size:	8,996 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL4_HUMAN, P05112 (See protein sequence)

Recommended Name: Interleukin-4 precursor

Size: 153 amino acids; 17492 Da

Subcellular location: Secreted

6/25 PDB 3D structures from and Proteopedia for IL4 (see all 25):

1BBN (3D)

1BCN (3D)

1CYL (3D)

1HIJ (3D)

1HIK (3D)

1HZI (3D)

Secondary accessions: Q14630

Alternative splicing: 2 isoforms: P05112-1 P05112-2

Explore the universe of human proteins at neXtProt for IL4: NX_P05112

IL4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000580.1 NP_758858.1

ENSEMBL proteins:

ENSP00000231449 ENSP00000325190

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant IL4 Protein
	R&D Systems Recombinant & Natural Proteins for IL4 (IL-4)
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	OriGene Purified Protein: IL4 OriGene Protein Over-expression Lysate (see all 2): IL4 OriGene Custom Protein Services for IL4
	GenScript Purified and Recombinant Proteins for IL4
	Novus Biologicals IL4 Proteins Novus Biologicals IL4 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IL4
	Uscn Proteins for IL4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	TAS	11418631
GO:0009897	external side of plasma membrane	IEA	--

IL4 for ontologies About GeneDecksing

IL4 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL4
	R&D Systems Antibodies for IL4 (IL-4)
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	OriGene Antibodies (see all 3): IL4 OriGene Custom Antibody Services for IL4
	GenScript Superior Antibodies for IL4
	Novus Biologicals IL4 Antibodies
	Abcam antibodies for IL4
	Uscn Antibodies for IL4
	ThermoFisher Antibody for IL4

Assay Products for IL4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for IL4 (IL-4) (see all)
	GenScript Custom Assay Services for IL4
	Cell Signaling Technology (CST) Sandwich ELISA Kits for IL4
	Enzo Life Sciences assays for IL4
	Uscn ELISAs and CLIAs for IL4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL4 for domains About GeneDecksing

5 InterPro domains/families:

IPR002354 Interleukin-4

IPR009079 4_helix_cytokine-like_core

IPR001325 Interleukin-4/13

IPR012351 4_helix_cytokine_core

IPR018096 Interleukin-4/-13_CS

Graphical View of Domain Structure for InterPro Entry P05112

ProtoNet protein and cluster: P05112

1 Blocks protein family: IPB001325 Interleukin-4/interleukin-13

UniProtKB/Swiss-Prot: IL4_HUMAN, P05112

Similarity: Belongs to the IL-4/IL-13 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IL4_HUMAN, P05112

Function: Participates in at least several B-cell activation processes as well as of other cell types. It is a

costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances

both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc

receptor for IgE (CD23) on both lymphocytes and monocytes

Genatlas biochemistry entry for IL4:

interleukin 4,15kDa,B-cell stimulating factor 1,important switch factor directing Ig-E synthesis

Summary:

During embryonic development, IL4 as signaling molecule is secreted from the following cells: Multinuclear Myocytes in Hindlimb Dorsal Muscle, Multinuclear Myocytes in Sacral Back Muscles (see all 14).

It affects the following cells: Mononuclear Myocytes in Hindlimb Ventral Muscle, Mononuclear Myocytes in Thoracic Primary Hypaxial Myotome (see all 20).

IL4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Immature dendritic-like cells, Dendritic-like cells (see all 20).

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL4
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate IL4:
		hsa-miR-340 hsa-miR-410
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL4 (see all 7) OriGene shRNA RFP: IL4 OriGene siRNA: IL4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): IL4 (NM_000589)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL4
		Search LifeMap BioReagents cell lines for IL4

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IL4

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005136	interleukin-4 receptor binding	TAS	11418631
GO:0005515	protein binding	IPI	18243101
GO:0008083	growth factor activity	NAS	11418631

IL4 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for IL4:

Synthetic lethal with imatinib

Animal Models:
     Mouse knock-outs for IL4: Il4^tm1Rao Il4^tm1Nnt Il4^tm2Nnt Il4/Il13^Il4/tm3Anjm Il4^tm1Kopf Il4^tm2Rao
                                               Il4^tm1Cgn
     15/19 MGI mutant phenotypes (inferred from 16 alleles) (MGI details for Il4) (see all 19):

cellular	craniofacial	digestive/alimentary	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	liver/biliary system
mortality/aging	nervous system	no phenotypic analysis	normal	renal/urinary system

IL4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/35 super-pathways (see all 35) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	Regulation of eIF4 and p70S6K	0.43
MAPK Family Pathway	0.60	SOCS Pathway	0.29
JAK-STAT Pathway	0.57

Allograft rejection

Allograft rejection	1.00	THC Differentiation Pathway	0.39
Autoimmune thyroid disease	0.60	Intestinal immune network for IgA production	0.38
Asthma	0.44

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for IL4

	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
	Immune response CD16 signaling in NK cells
	Selected targets of GCR-alpha
	Immune response IL-4 signaling pathway

4 R&D Systems Pathways for IL4

	IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types
	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
	IL-4 Signaling Pathways
	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/30 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL4 (see all 30)

	THC Differentiation Pathway
	Endothelin-1 Signaling Pathway
	IL-4 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C

1 Cell Signaling Technology (CST) Pathway for IL4

Lymphocyte Signaling

3 GeneGo (Thomson Reuters) Pathways for IL4

	Immune response IL-4 signaling pathway
	Immune response CD16 signaling in NK cells
	Immune response TLR signaling pathways

5/11 BioSystems Pathways for IL4 (see all 11)

	Cytokines and Inflammatory Response
	IL-4 signaling Pathway
	Calcium signaling in the CD4+ TCR pathway
	CD40/CD40L signaling
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes

5/11 Kegg Pathways (Kegg details for IL4) (see all 11):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	Hematopoietic cell lineage
	T cell receptor signaling pathway
	Fc epsilon RI signaling pathway

IL4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/57 Interacting proteins for IL4 (P05112^{1, 2, 3} ENSP00000231449⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL13RA1	P78552¹^,³, ENSP00000360730⁴	EBI-367025,EBI-3918927 I2D: score=1 STRING: ENSP00000360730
IL4R	P24394¹^,²^,³, ENSP00000170630⁴	EBI-367025,EBI-367009 MINT-24865 I2D: score=6 STRING: ENSP00000170630
IL13RA2	Q14627³, ENSP00000243213⁴	I2D: score=1 STRING: ENSP00000243213
A2M	P01023³, ENSP00000323929⁴	I2D: score=2 STRING: ENSP00000323929
CD53	P19397³, ENSP00000271324⁴	I2D: score=1 STRING: ENSP00000271324

About this table

Gene Ontology (GO): 5/51 biological process terms (GO ID links to tree view) (see all 51): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002227	innate immune response in mucosa	IEA	--
GO:0002296	T-helper 1 cell lineage commitment	IEA	--
GO:0002674	negative regulation of acute inflammatory response	IEA	--
GO:0002677	negative regulation of chronic inflammatory response	IEA	--
GO:0006935	chemotaxis	TAS	10725748

IL4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for IL4

Browse Tocris compounds for IL4
10/119 Novoseek chemical compound relationships for IL4 gene (see all 119) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
il 10	79.6	147	11166831 (5), 9800291 (4), 12944981 (3), 9624608 (3) (see all 99)
ionomycin	79.1	188	7751024 (6), 8599837 (5), 9158101 (3), 9876227 (3) (see all 99)
rantes	78.9	232	9644628 (5), 11106947 (5), 11385231 (4), 10975998 (4) (see all 99)
allergens	72.6	73	9252871 (3), 8039807 (2), 8612204 (2), 9863362 (2) (see all 57)
tarc	72.5	79	12871855 (5), 12441140 (4), 16810739 (4), 16102259 (4) (see all 35)
alpha-galactosylceramide	72.4	30	16447760 (2), 16027139 (2), 12902477 (1), 14768039 (1) (see all 26)
il-12	64.7	28	14503949 (2), 19398128 (2), 18610832 (2), 15688366 (2) (see all 21)
pge2	62.4	383	9870076 (6), 1845802 (5), 8385653 (5), 9683262 (5) (see all 99)
histamine	62.2	318	8670730 (7), 1372188 (5), 8859220 (5), 8644511 (5) (see all 99)
gm-csf	54.9	24	18166231 (3), 8431518 (2), 10785263 (2), 1751202 (2) (see all 15)

Search CenterWatch for drugs/clinical trials and news about IL4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL4 gene (2 alternative transcripts):

NM_000589.3 NM_172348.2

Unigene Cluster for IL4:

Interleukin 4

Hs.73917 [show with all ESTs]

Unigene Representative Sequence: AK310112

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000231449(uc003kxk.1 uc003kxl.1) ENST00000350025 ENST00000495905

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL4
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate IL4:
		hsa-miR-340 hsa-miR-410
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL4 (see all 7) OriGene shRNA RFP: IL4 OriGene siRNA: IL4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): IL4 (NM_000589)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL4

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL4

Additional cDNA sequence:

AB102862.1 AF043336.1 AK310112.1 AM937235.1 BC066277.1 BC066278.1 BC067514.1 BC067515.1

BC070123.1 EF173851.1 M13982.1 X81851.1

2 DOTS entries:

DT.101971469 DT.406716

22 AceView cDNA sequences:

NM_172348 BC067514 X81851 CD559677 NM_000589 CD640452 CD559676 BC070123

BC066278 BC067515 M13982 AF043336 BC066277 CD559527 CD559523 CD559526

CD559525 CD559524 T29166 AW953230 CD521402 CK130262

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for IL4 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4
SP1:
SP2:					-

ECgene alternative splicing isoforms for IL4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGAGAAAT

About this image

IL4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/14 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 14)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Forelimb Dorsal Muscles

Multinuclear Myocytes

Skeletal Muscle

Limb

Forelimb Ventral Muscles

Multinuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Dorsal Muscle

Multinuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Ventral Muscle

Multinuclear Myocytes

Skeletal Muscle

Anterior Neck Muscles

Multinuclear Myocytes

Skeletal Muscle

Cervical Back Muscles

Multinuclear Myocytes

Skeletal Muscle

Lumbar Back Muscles

Multinuclear Myocytes

Skeletal Muscle

Lumbar Vertebrae Column Muscles

Multinuclear Myocytes

Skeletal Muscle

Pelvic Muscles

Multinuclear Myocytes

Skeletal Muscle

Posterior Neck Muscles

Multinuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Bone marrow-derived mesenchymal stem cells (Stempeucel) (Adult Stem / Progenitor Cell)

Bone

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

See IL4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL4

SOURCE GeneReport for Unigene cluster: Hs.73917

SABiosciences Expression via Pathway-Focused PCR Arrays including IL4 (see all 23):

Interferons & Receptors in human mouse rat

Wound Healing in human mouse rat

T-cell & B-cell Activation in human mouse rat

Th17 Response in human mouse rat

Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL4

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IL4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for IL4 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il4^{1 , 5}	interleukin 4^{1, 5}	57.79(n)¹ 44.6(a)¹		11 (31.97 cM)⁵ 16189¹ NM_021283.2¹ NP_067258.1¹ 53602982⁵

ENSEMBL Gene Tree for IL4 (if available)
TreeFam Gene Tree for IL4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2243239^1,2	C,	--	127200041(+)	`GGATCA/GTTTTG`	2	--	us2k¹		3		NS WA	210
rs72797396^1,2	C,F,	--	127200216(+)	`TACAGT/AAAGCT`	2	--	us2k¹		1		NA	120
rs2243240^1,2	C,F,H,	--	127200318(+)	`AGCAAC/TACACA`	2	--	us2k¹		11		NS EA NA CSA WA	964
rs10080170^1,2	C,A,	--	127200437(+)	`gagatG/Tgagac`	2	--	us2k¹		0	--	--	--	--
rs10065221^1,2	C,	--	127200510(+)	`gtggcA/Gggtgc`	2	--	us2k¹		0	--	--	--	--
rs10058157^1,2	C,	--	127200513(+)	`gcaggT/Cgcctg`	2	--	us2k¹		1		NA	2
rs2243306^1,2		--	127200555(+)	`gagaaC/Tggcat`	2	--	us2k¹		2		NS	82
rs2243243^1,2	F,	--	127200559(+)	`acggcA/Gtgaac`	2	--	us2k¹		2		NS	82
rs2243244^1,2	F	--	127200568(+)	`acccaA/G/Tggagg`	2	--	us2k¹		2		NS	82
rs2243307^1,2	F	--	127200574(+)	`gaggcG/Agagct`	2	--	us2k¹		2		NS	80

HapMap Linkage Disequilibrium report for IL4 (132009373 - 132018368 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IL4
1 Indel: 46773
Human Gene Mutation Database (HGMD): IL4

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL4

DNA2.0 Custom Variant and Variant Library Synthesis for IL4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL4 for disorders About GeneDecksing

OMIM gene information: 147780 OMIM disorders: --

UniProtKB/Swiss-Prot: IL4_HUMAN, P05112

Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also

known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of

neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes,

resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous

disorders with multiple genetic and environmental risk factors

20/392 diseases for IL4 (see all 392): About MalaCards

hyper-ige syndrome transient acantholytic dermatosis graft versus host disease spinal cord injury

relapsing-remitting multiple sclerosis b-cell non-hodgkin lymphoma periapical granuloma severe combined immunodeficiency

churg-strauss syndrome cough variant asthma common variable immunodeficiency stevens-johnson syndrome

mitral valve prolapse gamma chain deficiency diffuse large b-cell lymphoma subacute sclerosing panencephalitis

langerhans-cell histiocytosis ocular cicatricial pemphigoid cicatricial pemphigoid sudden infant death syndrome

15 diseases from the University of Copenhagen DISEASES database for IL4:

Asthma Atopic dermatitis Hypersensitivity reaction type I disease Eosinophilia

Allergic rhinitis Hypersensitivity reaction type II disease Leishmaniasis Arthritis

Leukemia Lymphoma Schistosomiasis Connective tissue disease

Tuberculosis Tetanus Multiple sclerosis

10/97 Novoseek disease relationships for IL4 gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	86.4	2094	2032220 (3), 9127126 (3), 10768979 (3), 7622234 (3) (see all 99)
dermatitis atopic	81.8	229	15014952 (6), 11678851 (5), 1685830 (4), 8082305 (4) (see all 99)
asthma allergic	79.5	127	10810222 (4), 8250351 (3), 8534490 (3), 8902881 (3) (see all 77)
asthma	79.5	651	10336593 (5), 11991881 (5), 7648458 (5), 19910025 (5) (see all 99)
inflammation	78.7	397	8809430 (4), 18576346 (3), 8376806 (2), 7673736 (2) (see all 99)
allergy	73.7	145	12363420 (3), 10460779 (2), 18031948 (2), 8908280 (2) (see all 99)
tumors	73.5	2022	9816099 (7), 20003817 (6), 8423237 (5), 8280717 (5) (see all 99)
atopy	73.4	122	10753021 (3), 15087090 (3), 12911786 (3), 11990231 (2) (see all 85)
severe combined immunodeficiency, x-linked	71.7	48	8557662 (3), 7937790 (2), 8026467 (1), 7803808 (1) (see all 32)
eosinophilia	70.7	114	11776778 (2), 12789240 (2), 14768039 (2), 10592468 (2) (see all 77)

Genetic Association Database (GAD): IL4
Human Genome Epidemiology (HuGE) Navigator: IL4 (493 documents)
Tumor Gene Database (TGDB): IL4

Export disorders for IL4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL4 gene, integrated from 9 sources (see all 5360):
(articles sorted by number of sources associating them with IL4)

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Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B- cell- and T-cell-stimulating activities. (PubMed id 3016727)^{1, 2, 3} Yokota T.... Arai K. (1986)
[Correlation between polymorphism of IL-4 and IL-10 gene promoter and childhood asthma and their impact upon cytokine expression] (PubMed id 11953141)^{1, 4, 9} Zhang J....Chen Y. (2002)
Epistatic effect of TLR4 and IL4 genes on the risk of asthma in females. (PubMed id 16215326)^{1, 4, 9} Adjers K....Hurme M. (2005)
Interleukin (IL)-4, IL-10, IL-18 and IFN-gamma cytokines pattern in patients with combined hepatitis C virus and Schistosoma mansoni infections. (PubMed id 15644127)^{1, 4, 9} El-Kady I.M....Waked I. (2005)
Relationships between specific serum IgE, cytokines and polymorphisms in the IL-4, IL-4Ralpha in patients with penicillins allergy. (PubMed id 15969687)^{1, 4, 9} Qiao H.L....Zhang Y.W. (2005)
Association and interaction of the IL4R, IL4, and IL13 loci with type 1 diabetes among Filipinos. (PubMed id 12748907)^{1, 4, 9} Bugawan T.L....Erlich H.A. (2003)
Lack of association between atopic eczema and the genetic variants of interleukin-4 and the interleukin-4 receptor alpha chain gene: heterogeneity of genetic backgrounds on immunoglobulin E production in atopic eczema patients. (PubMed id 11678851)^{1, 4, 9} Tanaka K....Montgomery D.S. (2001)
Lack of association of genetic polymorphisms in the interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4 and interleukin-10 genes with mitral valve prolapse in Taiwan Chinese. (PubMed id 12578333)^{1, 4, 9} Chou H.T....Tsai F.J. (2003)
Association of IL-1Ra gene polymorphism, but no association of IL-1beta and IL-4 gene polymorphisms, with Kawasaki disease. (PubMed id 15900570)^{1, 4, 9} Wu S.F....Tsai F.J. (2005)
Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study. (PubMed id 15007352)^{1, 4, 9} Liu X....Nickel R. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3565	HGNC: 6014	AceView: IL4	Ensembl:ENSG00000113520	euGenes: HUgn3565
ECgene: IL4	Kegg: 3565	H-InvDB: IL4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for IL4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL4	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/il4/

Intellectual Property for IL4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IL4 gene:
Search GeneIP for patents involving IL4

GeneCards and IP:
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Leukemia B-Cell
Chronic sinusitis
HYPER-IgM SYNDROME
Leprosy Lepromatous
Genetic Susceptibility
IMMUNE DISORDER
Conjunctival Diseases
immunopathology
Dermatitis Atopic
Allergic Reaction
Colitis Ulcerative
Hypersensitivity Contact
AIRWAYS DISEASE
Keratoconjunctivitis Vernal
allergy
Skin Diseases
Eczema
Rhinitis Allergic Seasonal
Pulmonary Eosinophilia
Asthma
Allergic rhinitis
OMENN SYNDROME
Uveitis
Lymphoma
Bronchoalveolar Lavage Fluid
Nasal Polyps
Leishmaniasis Cutaneous
Multiple Sclerosis
Burkitt Lymphoma
Inflammation
Anaphylaxis
Tuberculosis
immunodeficiency
Psoriasis
MYELOMA
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Rheumatoid Arthritis
Conjunctivitis Vernal
Aspergillosis Allergic Bronchopulmonary
Allergies Egg
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Necrosis
Rhinitis
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virus infection
Lymphoma T-Cell Cutaneous
Hypersensitivity Immediate
Hypogammaglobulinemia
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atopy
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mycobacterial infection
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Common Variable Immunodeficiency
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Severe Combined Immunodeficiency
Myasthenia Gravis
Allergy Food
Bronchial Hyperreactivity
SEVERE COMBINED IMMUNODEFICIENCY, X-LINKED
Asthma childhood
Intrinsic asthma
metastatic melanoma
Lymphopenia
Carcinoma Renal Cell
Acute graft-versus-host disease
Hypersensitivity Delayed
Inflammatory Bowel Diseases
Schistosomiasis
Sezary Syndrome
HIV Infections
Eosinophilia
Lymphocytic Leukemia Chronic B-Cell
Rhinitis Allergic Perennial
SKIN LESION
Hepatitis C Chronic
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Graves Disease
IGA DEFICIENCY SELECTIVE
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Hashimotos Thyroiditis
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LEUKAEMIA LYMPHOCYTIC
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IL4 Gene

interleukin 4

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