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IL4 Gene

protein-coding GIFtS: 71

GC05P132037

interleukin 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BCGF-1 ^¹, ²
BCGF1 ^¹, ²
BSF-1 ^³
BSF1 ^¹, ²
Binetrakin ^³
IL-4 ^¹, ², ³
MGC79402 ^²
Pitrakinra ^³

Descriptions
B cell growth factor 1 ^²
B-cell stimulatory factor 1 ^³
B_cell stimulatory factor 1 ^²
Lymphocyte stimulatory factor 1 ^², ³
interleukin 4 ^²

External Ids
HGNC: 6014¹
Entrez Gene: 3565²
UniProtKB: P05112³
Ensembl: ENSG00000113520⁷

Search outside databases for aliases for IL4 gene

Previous GC identifers: GC05P131531 GC05P132456 GC05P132041 GC05P132085

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IL4:

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This

cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13,

which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal

transducer and activator of transcription, has been shown to play a central role in mediating the

immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine

gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5

are found to be regulated coordinately by several long-range regulatory elements in an over 120

kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene

encoding distinct isoforms have been reported. [provided by RefSeq]

UniProtKB/Swiss-Prot: IL4_HUMAN, P05112

Function: Participates in at least several B-cell activation processes as well as of other cell

types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules

on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It

also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes

and monocytes

Gene Wiki entry for IL4 (Interleukin_4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IL4 gene

Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q23-q31

IL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P132037: (about GC identifiers)

Start:	132,037,272 bp from pter
End:	132,046,267 bp from pter
Size:	8,996 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_034772.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: IL4_HUMAN, P05112 (See protein sequence)

Recommended Name: Interleukin-4 precursor

Size: 153 amino acids; 17492 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

1BBN (3D)

1BCN (3D)

1CYL (3D)

1HIJ (3D)

1HIK (3D)

1HZI (3D)

1IAR (3D)

1ILL (3D)

1ITE (3D)

1ITI (3D)

1ITL (3D)

1ITM (3D)

1RCB (3D)

2B8U (3D)

2B8X (3D)

2B8Y (3D)

2B8Z (3D)

2B90 (3D)

2B91 (3D)

2CYK (3D)

2D48 (3D)

2INT (3D)

3BPL (3D)

3BPN (3D)

Secondary accessions: Q14630

Alternative splicing: 2 isoforms: P05112-1 P05112-2

REFSEQ proteins (2 alternative transcripts):

NP_000580.1 NP_758858.1

ENSEMBL proteins:

ENSP00000231449 ENSP00000325190

Human Recombinant Proteins

	Invitrogen human recombinant proteins for IL4
	Millipore Purified and/or Recombinant IL4 Protein
	Sigma-Aldrich Proteins for IL4
	R&D Systems Recombinant & Natural Proteins for IL4 (IL-4)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IL4, IL10 + IL4, Interferon gamma + IL4)
	Human Recombinant Proteins from Abnova (IL4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	11418631

About this table

Antibodies for IL4:

	Invitrogen Antibodies for IL4
	Millipore Mono- and Polyclonal Antibodies for the study of IL4
	Sigma-Aldrich Antibodies for IL4
	R&D Systems Antibodies for IL4 (IL-4)
	Antibodies from Abcam (IL4, IL10 + IL4, Interferon gamma + IL4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IL4)
	Novus Biologicals Antibodies for IL4

Assays for IL4:

	Invitrogen Assays for IL4
	Millipore Kits and Assays for the Analysis of IL4
	R&D Systems Flow Cytometry Kits for IL4 (IL-4) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P05112

ProtoNet protein and cluster: P05112

1 Blocks protein family: IPB001325 Interleukin-4/interleukin-13

UniProtKB/Swiss-Prot: IL4_HUMAN, P05112

Similarity: Belongs to the IL-4/IL-13 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IL4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IL4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000589

Applied Biosystems Silencer® siRNAs for IL4

Sigma-Aldrich siRNA and siRNA Panels for IL4

Sigma-Aldrich shRNA Panels and shRNA for IL4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IL4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000589
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000589
untagged cDNA clones in CMV expression vector (see all 2): NM_000589

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000589

UniProtKB/Swiss-Prot: IL4_HUMAN, P05112

Function: Participates in at least several B-cell activation processes as well as of other cell

types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules

on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It

also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes

and monocytes

Genatlas biochemistry entry for IL4:

interleukin 4,15kDa,B-cell stimulating factor 1,important switch factor directing Ig-E synthesis

13 MGI mutant phenotypes (inferred from 14 alleles) (MGI details for Il4):

cellular	digestive/alimentary	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism
immune system	lethality-postnatal	liver/biliary system	nervous system	no phenotypic analysis
normal	renal/urinary system	vision/eye

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005136	interleukin-4 receptor binding	TAS	11418631
GO:0005515	protein binding	IPI	8266078

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/11 Sigma-Aldrich "Your Favorite Gene" Pathways for IL4 (Your Favorite Gene powered by Ingenuity) (see all 11 )

T Helper Cell Differentiation
Airway Inflammation in Asthma
IL-4 Signaling
IL-15 Signaling
Allograft Rejection Signaling

GeneDecks IL4 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for IL4

5/318 Interacting proteins for IL4 (ENSP00000231449³ P05112^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 318 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL4R	P24394¹^,²	STRING (score=.999) EBI-367025, EBI-367009 MINT-24865 EBI-367025, EBI-367009 MINT-24865
IL4R	P24394¹^,²	STRING (score=.999) EBI-367025, EBI-367009 MINT-24865 EBI-367025, EBI-367009 MINT-24865
IL13RA1	ENSP00000360730³	STRING (score=.999)
IL2	ENSP00000226730³	STRING (score=.999)
IL2RG	ENSP00000276110³	STRING (score=.999)

About this table

5/17 Gene Ontology (GO) biological process terms (links to tree view) (see all 17 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006935	chemotaxis	TAS	10725748
GO:0006968	cellular defense response	TAS	10725748
GO:0008203	cholesterol metabolic process	ISS	11971948
GO:0030183	B cell differentiation	TAS	11418631
GO:0030890	positive regulation of B cell proliferation	ISS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for IL4:

Antagonist

Browse Tocris compounds for IL4
10/18 Novoseek chemical compound relationships for IL4 gene (see all 18 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
il 10	79.75	135	11166831 (5), 9800291 (4), 12944981 (3), 9624608 (3) (see all 98)
ionomycin	79.11	186	7751024 (6), 8599837 (5), 9158101 (3), 9876227 (3) (see all 99)
rantes	78.66	221	9644628 (5), 11106947 (5), 11385231 (4), 10975998 (4) (see all 99)
alpha-galactosylceramide	72.35	28	16447760 (2), 16027139 (2), 12902477 (1), 14768039 (1) (see all 24)
allergens	71.98	71	9252871 (3), 8039807 (2), 8612204 (2), 9863362 (2) (see all 55)
tarc	71.39	77	12871855 (5), 12441140 (4), 16810739 (4), 16102259 (4) (see all 34)
il-12	63.42	25	14503949 (2), 18610832 (2), 15688366 (2), 17565376 (1) (see all 19)
thymidine	54.39	79	2013100 (2), 7949016 (2), 7490461 (2), 8464242 (2) (see all 66)
con a	48.20	28	15627644 (3), 1309751 (3), 12849703 (2), 7807282 (1) (see all 20)
tyrosine	46.39	253	7929391 (4), 7518439 (4), 10845915 (4), 8186375 (3) (see all 99)

About this table

1 PharmGKB drug compound relationship for IL4 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
glucocorticoids	FA	10623828

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IL4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IL4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000589

Sigma-Aldrich siRNA and siRNA Panels for IL4

Sigma-Aldrich shRNA Panels and shRNA for IL4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000589 NM_172348

REFSEQ mRNAs for IL4 gene (2 alternative transcripts):

NM_000589.2 NM_172348.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000589 NM_172348

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000589
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000589
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000589

Additional cDNA sequence:

AB102862.1 AF043336.1 AK310112.1 AM937235.1 BC066277.1 BC066278.1 BC067514.1 BC067515.1

BC070123.1 EF173851.1 M13982.1 X81851.1

2 DOTS entries:

DT.101971469 DT.406716

22 AceView cDNA sequences:

BC067514 NM_000589 CD559677 NM_172348 X81851 CD559676 CD640452 BC067515

BC066278 AF043336 BC066277 CD559527 BC070123 M13982 CD559523 CD559525

CD559526 CD559524 T29166 AW953230 CD521402 CK130262

highest scoring ESTs for IL4:

M13982 X81851 AF043336 AW953230 BC066277 BC066278 BC067514 BC067515 BC070123 CD521402

Unigene Cluster for IL4:

Interleukin 4

Hs.73917 [show with all ESTs]

Unigene Representative Sequence: AK310112

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for IL4

ExUns:	1a	·	1b	^	2	^	3	^	4
SP1:
SP2:					-

About this scheme

ECgene alternative splicing isoforms for IL4

2 Ensembl transcripts including schematic representations:

ENST00000231449 ENST00000350025

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IL4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IL4

¹ / ² / ³

6 probe-sets matching IL4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33981_at²^{, 3}	U95-A	1	1.00	1.00	0.32	0.19	X81851	1.00	1.00	1.00	1
1574_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M13982	1.00	1.00	1.00	1
207538_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000589	0.60	1.00	0.82	1
207539_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000589	0.60	1.00	0.82	1
207538_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207539_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGAGAGAAAT

SOURCE GeneReport for Unigene cluster: Hs.73917
Expression variation in blood from EXPOLDB for IL4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IL4 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IL4¹	--	interleukin 4	72.61(n) 57.36(a)	403785 NM_001003159.1 NP_001003159.1
chimpanzee (Pan troglodytes)	IL4¹	--	interleukin 4	99.78(n) 99.35(a)	449565 NM_001011714.1 NP_001011714.1
cow (Bos taurus)	IL4¹	--	interleukin 4	74.94(n) 65.41(a)	280824 NM_173921.2 NP_776346.1
rat (Rattus norvegicus)	Il4¹	--	interleukin 4	59.95(n) 46.53(a)	287287 NM_201270.1 NP_958427.1
mouse (Mus musculus)	Il4^{1, 5}	11 (29.00 cM)⁵	interleukin 4^{1, 5}	57.79(n)¹ 44.6(a)¹	16189¹ NM_021283.1¹ NP_067258.1¹ AA199406⁵ AB174765⁵ (see all 18)

About this table Species with no ortholog for IL4

ENSEMBL Gene Tree for IL4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/153 NCBI SNPs in IL4 are shown (see all 153 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 82)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2243250^1,2	A,C,F,H	132037053(+)	`ATTGTT/CCCCCA`	2	--	ng5¹		13	NS MN CSAM EA EU WA NA	1130
	rs2070874^1,2	A,C,F,H	132037609(+)	`AATTGC/TCTCAC`	2	--	ut5¹ ese³		24	EA NS MN CSAM NA EU WA	3602
	rs2243248^1,2	C,F,H,O	132036543(+)	`AAGACT/GGTAGC`	2	--	ng5¹		23	NS EU EA WA MN CSAM NA	1954
	rs4986963^1,2	C,F,H	132037122(+)	`ATCAGC/TTTTTC`	2	--	ng5¹		10	MN CSAM EA EU WA	990
	rs4986964^1,2	C,F,H	132037720(+)	`ACAAGT/CGCGAT`	2	R/C	mis¹ ese³		10	MN CSAM EA EU WA	988
	rs2243246^1,2	C,F,H	132036307(+)	`GGTTCT/CGGGAG`	2	--	ng5¹		12	NS EU EA WA	1094
--	rs2243249^1,2	C,F	132036596(+)	`AAAAGT/CGGGCA`	2	--	ng5¹		7	NS MN CSAM EA	476
	rs17772853^1,2	F,H	132037498(+)	`TGTAAC/TGAAAA`	2	--	ut5¹		7	NA EU EA WA	558
	rs2243240^1,2	F,H	132035915(+)	`AGCAAC/TACACA`	2	--	ng5¹		6	NS EU EA WA	482
	rs2243247^1,2	C,F	132036505(+)	`GTGGGG/ACACTG`	2	--	ng5¹		14	NS MN CSAM EA	1276

About this table

HapMap Linkage Disequilibrium images for IL4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147780

UniProtKB/Swiss-Prot: IL4_HUMAN, P05112

Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke

[MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute

neurologic event leading to death of neural tissue of the brain and resulting in loss of motor,

sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is

considered to be a highly complex disease consisting of a group of heterogeneous disorders with

multiple genetic and environmental risk factors

10/96 Novoseek disease relationships for IL4 gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	86.32	1948	2032220 (3), 9127126 (3), 10768979 (3), 7622234 (3) (see all 99)
dermatitis atopic	81.54	223	15014952 (6), 11678851 (5), 1685830 (4), 8082305 (4) (see all 99)
asthma	78.95	605	10336593 (5), 11991881 (5), 7648458 (5), 16215326 (5) (see all 99)
asthma allergic	78.82	124	10810222 (4), 8250351 (3), 8534490 (3), 8902881 (3) (see all 74)
inflammation	78.31	371	8809430 (4), 18576346 (3), 8376806 (2), 7673736 (2) (see all 99)
atopy	73.55	118	10753021 (3), 15087090 (3), 12911786 (3), 11990231 (2) (see all 82)
allergy	72.96	129	12363420 (3), 10460779 (2), 18031948 (2), 8908280 (2) (see all 96)
tumors	72.86	1879	9816099 (7), 8423237 (5), 8280717 (5), 1651157 (5) (see all 99)
severe combined immunodeficiency, x-linked	72.45	48	8557662 (3), 7937790 (2), 8026467 (1), 7803808 (1) (see all 32)
eosinophilia	70.44	101	11776778 (2), 12789240 (2), 12007717 (2), 17996260 (2) (see all 70)

About this table

Human Gene Mutation Database: IL4
Genetic Association Database: IL4
Human Genome Epidemiology Navigator: IL4 (352 documents)
Tumor Gene Database: IL4

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/4464 PubMed articles for IL4 gene (see all 4464 ):

Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B- cell- and T-cell-stimulating activities. (PubMed id 3016727)^{2, 3, 4} Yokota T.... Arai K. (1986)
[Correlation between polymorphism of IL-4 and IL-10 gene promoter and childhood asthma and their impact upon cytokine expression] (PubMed id 11953141)^{1, 3, 6} Zhang J....Chen Y. (2002)
Interleukin (IL)-4, IL-10, IL-18 and IFN-gamma cytokines pattern in patients with combined hepatitis C virus and Schistosoma mansoni infections. (PubMed id 15644127)^{1, 3, 6} El-Kady I.M....Waked I. (2005)
Relationships between specific serum IgE, cytokines and polymorphisms in the IL-4, IL-4Ralpha in patients with penicillins allergy. (PubMed id 15969687)^{1, 3, 6} Qiao H.L....Zhang Y.W. (2005)
Association and interaction of the IL4R, IL4, and IL13 loci with type 1 diabetes among Filipinos. (PubMed id 12748907)^{1, 3, 6} Bugawan T.L....Erlich H.A. (2003)
Lack of association between atopic eczema and the genetic variants of interleukin-4 and the interleukin-4 receptor alpha chain gene: heterogeneity of genetic backgrounds on immunoglobulin E production in atopic eczema patients. (PubMed id 11678851)^{1, 3, 6} Tanaka K....Montgomery D.S. (2001)
Lack of association of genetic polymorphisms in the interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4 and interleukin-10 genes with mitral valve prolapse in Taiwan Chinese. (PubMed id 12578333)^{1, 3, 6} Chou H.T....Tsai F.J. (2003)
Association of IL-1Ra gene polymorphism, but no association of IL-1beta and IL-4 gene polymorphisms, with Kawasaki disease. (PubMed id 15900570)^{1, 3, 6} Wu S.F....Tsai F.J. (2005)
Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study. (PubMed id 15007352)^{1, 3, 6} Liu X....Nickel R. (2004)
Genetic variants of FcepsilonRIbeta and Il-4 and atopy in a Polish population. (PubMed id 15087090)^{1, 3, 6} Korzycka-Zaborowska B....Gorski P. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3565	HGNC: 6014	AceView: IL4	Ensembl:ENSG00000113520	euGenes: HUgn3565
ECgene: IL4	H-InvDB: IL4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for IL4	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/il4/

Licensable Technologies for IL4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IL4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IL4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IL4		Antibodies for IL4
	Explore super-pooled esiRNAs		Proteins for IL4
	Lentivirus-delivered shRNAs for IL4		Small molecules for IL4
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IL4)
	Antibodies (IL4)
	Chimera RNAi (IL4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (IL4, IL10 + IL4, Interferon gamma + IL4)
	Antibodies (IL4, IL10 + IL4, Interferon gamma + IL4)

Search OriGene for IL4

Search Tocris compounds for IL4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IL4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
IL4 Gene at Home site.
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IL4 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for IL4

Summaries
for IL4

Genomic Location
for IL4

Proteins
for IL4

Protein Domains/
Families
for IL4

Gene Function
for IL4

Pathways & Interactions
for IL4

Drugs & Compounds
for IL4

Transcripts
for IL4

Expression
for IL4

Orthologs
for IL4

Paralogs
for IL4

SNPs/Variants
for IL4

Disorders & Mutations
for IL4

Medical News
for IL4

Publications
for IL4

Search for IL4

Genome Databases showing IL4

Other Databases showing IL4

Specialized Databases showing IL4

Licensable Technologies
for IL4

Services
for IL4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IL4 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor IL4

Summariesfor IL4

Genomic Locationfor IL4

Proteinsfor IL4

Protein Domains/Familiesfor IL4

Gene Functionfor IL4

Pathways & Interactionsfor IL4

Drugs & Compoundsfor IL4

Transcriptsfor IL4

Expression for IL4

Orthologsfor IL4

Paralogsfor IL4

SNPs/Variantsfor IL4

Disorders & Mutationsfor IL4

Medical Newsfor IL4

Publicationsfor IL4

Search for IL4

Genome Databases showing IL4

Other Databases showing IL4

Specialized Databases showing IL4

Licensable Technologiesfor IL4

Servicesfor IL4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IL4

Summaries
for IL4

Genomic Location
for IL4

Proteins
for IL4

Protein Domains/
Families
for IL4

Gene Function
for IL4

Pathways & Interactions
for IL4

Drugs & Compounds
for IL4

Transcripts
for IL4

Expression
for IL4

Orthologs
for IL4

Paralogs
for IL4

SNPs/Variants
for IL4

Disorders & Mutations
for IL4

Medical News
for IL4

Publications
for IL4

Licensable Technologies
for IL4

Services
for IL4