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Aliases for IL3RA Gene

Aliases for IL3RA Gene

  • Interleukin 3 Receptor Subunit Alpha 2 3 5
  • Interleukin 3 Receptor, Alpha (Low Affinity) 2 3
  • IL-3 Receptor Subunit Alpha 3 4
  • IL-3R Subunit Alpha 3 4
  • CD123 Antigen 3 4
  • IL-3R-Alpha 3 4
  • IL-3RA 3 4
  • IL3R 3 4
  • IL-3 Receptor Alpha SP2 Isoform 3
  • HIL-3Ra 3
  • IL3RAY 3
  • CD123 3
  • IL3RX 3
  • IL3RY 3

External Ids for IL3RA Gene

Previous GeneCards Identifiers for IL3RA Gene

  • GC00U990171
  • GC0YU900011
  • GC0XP9H0000
  • GC0YP001499
  • GC0XP001499
  • GC0XP001415
  • GC0XP001455

Summaries for IL3RA Gene

Entrez Gene Summary for IL3RA Gene

  • The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

GeneCards Summary for IL3RA Gene

IL3RA (Interleukin 3 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL3RA include Diphtheria and Acute Basophilic Leukemia. Among its related pathways are p70S6K Signaling and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include cytokine receptor activity and interleukin-3 receptor activity. An important paralog of this gene is CSF2RA.

UniProtKB/Swiss-Prot for IL3RA Gene

  • This is a receptor for interleukin-3.

Gene Wiki entry for IL3RA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL3RA Gene

Genomics for IL3RA Gene

Regulatory Elements for IL3RA Gene

Enhancers for IL3RA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL3RA on UCSC Golden Path with GeneCards custom track

Promoters for IL3RA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL3RA on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IL3RA gene promoter:

Genomic Location for IL3RA Gene

Chromosome:
X
Start:
1,336,587 bp from pter
End:
1,382,689 bp from pter
Size:
46,103 bases
Orientation:
Plus strand

Genomic View for IL3RA Gene

Genes around IL3RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL3RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL3RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL3RA Gene

Proteins for IL3RA Gene

  • Protein details for IL3RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26951-IL3RA_HUMAN
    Recommended name:
    Interleukin-3 receptor subunit alpha
    Protein Accession:
    P26951
    Secondary Accessions:
    • A8K3F3
    • B9VI81
    • Q5HYQ7
    • Q5HYQ8
    • Q9UEH7

    Protein attributes for IL3RA Gene

    Size:
    378 amino acids
    Molecular mass:
    43330 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
    SequenceCaution:
    • Sequence=BAA08393.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL3RA Gene

    Alternative splice isoforms for IL3RA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL3RA Gene

Proteomics data for IL3RA Gene at MOPED

Post-translational modifications for IL3RA Gene

  • Glycosylation at Asn 46, Asn 64, Asn 80, Asn 109, Asn 212, and Asn 218
  • Modification sites at PhosphoSitePlus

Other Protein References for IL3RA Gene

Antibody Products

  • R&D Systems Antibodies for IL3RA (IL-3 R alpha/CD123)

No data available for DME Specific Peptides for IL3RA Gene

Domains & Families for IL3RA Gene

Suggested Antigen Peptide Sequences for IL3RA Gene

Graphical View of Domain Structure for InterPro Entry

P26951

UniProtKB/Swiss-Prot:

IL3RA_HUMAN :
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
Family:
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
genes like me logo Genes that share domains with IL3RA: view

Function for IL3RA Gene

Molecular function for IL3RA Gene

UniProtKB/Swiss-Prot Function:
This is a receptor for interleukin-3.

Gene Ontology (GO) - Molecular Function for IL3RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
genes like me logo Genes that share ontologies with IL3RA: view
genes like me logo Genes that share phenotypes with IL3RA: view

Human Phenotype Ontology for IL3RA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IL3RA Gene

Localization for IL3RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL3RA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL3RA Gene COMPARTMENTS Subcellular localization image for IL3RA gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IL3RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL3RA: view

Pathways & Interactions for IL3RA Gene

SuperPathways for IL3RA Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 PEDF Induced Signaling
3 TGF-Beta Pathway
4 Akt Signaling
5 G beta-gamma signalling through PI3Kgamma
genes like me logo Genes that share pathways with IL3RA: view

SIGNOR curated interactions for IL3RA Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL3RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007411 axon guidance TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with IL3RA: view

Drugs & Compounds for IL3RA Gene

(8) Drugs for IL3RA Gene - From: DrugBank, DGIdb, FDA Approved Drugs, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sargramostim Approved, Investigational Pharma Target, agonist 0
Leukine Approved on November 24, 1995/ Approved November 1996 Pharma 0
IL-3 Pharma Agonist 0
CSL 360 Pharma 0

(5) Additional Compounds for IL3RA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL3RA: view

Transcripts for IL3RA Gene

Unigene Clusters for IL3RA Gene

Interleukin 3 receptor, alpha (low affinity):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL3RA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2:
SP3: - -

Relevant External Links for IL3RA Gene

GeneLoc Exon Structure for
IL3RA
ECgene alternative splicing isoforms for
IL3RA

Expression for IL3RA Gene

mRNA expression in normal human tissues for IL3RA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IL3RA Gene

This gene is overexpressed in Gallbladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL3RA Gene



SOURCE GeneReport for Unigene cluster for IL3RA Gene Hs.632790

genes like me logo Genes that share expression patterns with IL3RA: view

Protein tissue co-expression partners for IL3RA Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IL3RA Gene

Orthologs for IL3RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL3RA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL3RA 35
  • 58.95 (n)
  • 44 (a)
dog
(Canis familiaris)
Mammalia IL3RA 35
  • 63.8 (n)
  • 47.31 (a)
IL3RA 36
  • 38 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il3ra 35
  • 48.29 (n)
  • 33.73 (a)
Il3ra 16
Il3ra 36
  • 26 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL3RA 35
  • 84.22 (n)
  • 80.15 (a)
rat
(Rattus norvegicus)
Mammalia Il3ra 35
  • 47.93 (n)
  • 33.73 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 23 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 23 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
Species with no ortholog for IL3RA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL3RA Gene

ENSEMBL:
Gene Tree for IL3RA (if available)
TreeFam:
Gene Tree for IL3RA (if available)

Paralogs for IL3RA Gene

Paralogs for IL3RA Gene

(1) SIMAP similar genes for IL3RA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IL3RA: view

Variants for IL3RA Gene

Sequence variations from dbSNP and Humsavar for IL3RA Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_021113 -
VAR_021114 -
VAR_021115 -
VAR_021116 -

Structural Variations from Database of Genomic Variants (DGV) for IL3RA Gene

Variant ID Type Subtype PubMed ID
esv29996 CNV Loss 17803354
esv21933 CNV Gain+Loss 19812545
esv2670115 CNV Deletion 23128226
esv2663551 CNV Deletion 23128226
esv2739678 CNV Deletion 23290073
esv2739679 CNV Deletion 23290073
esv2739680 CNV Deletion 23290073
esv2661406 CNV Deletion 23128226
esv2656955 CNV Deletion 23128226
esv2739681 CNV Deletion 23290073
esv2739682 CNV Deletion 23290073
esv2166277 CNV Deletion 18987734
esv2739683 CNV Deletion 23290073
esv2739685 CNV Deletion 23290073
esv2673745 CNV Deletion 23128226
nsv820760 CNV Deletion 20802225
dgv1357e201 CNV Deletion 23290073
dgv1358e201 CNV Deletion 23290073
esv2666429 CNV Deletion 23128226
esv2739693 CNV Deletion 23290073
esv2739694 CNV Deletion 23290073
esv2739697 CNV Deletion 23290073

Variation tolerance for IL3RA Gene

Residual Variation Intolerance Score: 75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IL3RA Gene

Disorders for IL3RA Gene

MalaCards: The human disease database

(8) MalaCards diseases for IL3RA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diphtheria
  • corynebacterium infection
acute basophilic leukemia
blastic plasmacytoid dendritic cell
  • blastic nk-cell lymphoma
hematologic cancer
  • blood cancer
infiltrating lipoma
  • intramuscular lipoma
- elite association - COSMIC cancer census association via MalaCards
Search IL3RA in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL3RA

Genetic Association Database (GAD)
IL3RA
Human Genome Epidemiology (HuGE) Navigator
IL3RA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL3RA
genes like me logo Genes that share disorders with IL3RA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL3RA Gene

Publications for IL3RA Gene

  1. Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors. (PMID: 1833064) Kitamura T. … Miyajima A. (Cell 1991) 2 3 4 67
  2. Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. (PMID: 17522711) Lencz T. … Malhotra A.K. (Mol. Psychiatry 2007) 3 23 25
  3. A new isoform of IL-3 receptor alpha with novel differentiation activity and high affinity binding mode. (PMID: 19109256) Chen J. … Young I.G. (J. Biol. Chem. 2009) 3 23
  4. A family-based study of the IL3RA gene on susceptibility to schizophrenia in a Chinese Han population. (PMID: 19281803) Sun S. … Zhang X.Y. (Brain Res. 2009) 3 23
  5. Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population. (PMID: 18547720) Sun S. … Zhang X.Y. (Neurosci. Lett. 2008) 3 23

Products for IL3RA Gene

Sources for IL3RA Gene

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