Aliases for IL3RA Gene
External Ids for IL3RA Gene
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]
GeneCards Summary for IL3RA Gene
IL3RA (Interleukin 3 Receptor, Alpha (Low Affinity)) is a Protein Coding gene. Diseases associated with IL3RA include cd4+/cd56+ hematodermic neoplasm and acute leukemia. Among its related pathways are PI3K-Akt signaling pathway and Akt Signaling. GO annotations related to this gene include interleukin-3 receptor activity. An important paralog of this gene is CSF2RA.
UniProtKB/Swiss-Prot for IL3RA Gene
This is a receptor for interleukin-3