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Aliases for IL3RA Gene

Aliases for IL3RA Gene

  • Interleukin 3 Receptor Subunit Alpha 2 3 5
  • Interleukin 3 Receptor, Alpha (Low Affinity) 2 3
  • IL-3 Receptor Subunit Alpha 3 4
  • IL-3R Subunit Alpha 3 4
  • CD123 Antigen 3 4
  • IL-3R-Alpha 3 4
  • IL-3RA 3 4
  • IL3R 3 4
  • Interleukin-3 Receptor Subunit Alpha 3
  • IL-3 Receptor Alpha SP2 Isoform 3
  • HIL-3Ra 3
  • IL3RAY 3
  • CD123 3
  • IL3RX 3
  • IL3RY 3

External Ids for IL3RA Gene

Previous GeneCards Identifiers for IL3RA Gene

  • GC00U990171
  • GC0YU900011
  • GC0XP9H0000
  • GC0YP001499
  • GC0XP001499
  • GC0XP001415
  • GC0XP001455

Summaries for IL3RA Gene

Entrez Gene Summary for IL3RA Gene

  • The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

GeneCards Summary for IL3RA Gene

IL3RA (Interleukin 3 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL3RA include Hairy Cell Leukemia and Acute Basophilic Leukemia. Among its related pathways are RET signaling and Signaling by GPCR. GO annotations related to this gene include cytokine receptor activity and interleukin-3 receptor activity. An important paralog of this gene is CSF2RA.

UniProtKB/Swiss-Prot for IL3RA Gene

  • This is a receptor for interleukin-3.

Gene Wiki entry for IL3RA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL3RA Gene

Genomics for IL3RA Gene

Regulatory Elements for IL3RA Gene

Enhancers for IL3RA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF001246 1.3 FANTOM5 Ensembl 14.8 -88.1 -88086 3.8 ZNF121 GTF3C2 CBX5 ZNF143 FOS ZNF263 REST ZNF264 NBN KDM1A CSF2RA AKAP17A IL3RA ASMTL CRLF2 ASMT P2RY8 SLC25A6
GH0XF001316 0.9 FANTOM5 Ensembl 19.8 -19.8 -19787 1.2 SCRT1 CTCF POLR2A ZNF366 CSF2RA IL3RA ASMTL AKAP17A ASMT SLC25A6 P2RY8 CRLF2 GC0XM001318 RNA5SP498
GH0XF001222 1.1 FANTOM5 Ensembl 15.8 -113.6 -113561 1.1 ESRRA JUN MAX CEBPB ZIC2 EP300 JUND RCOR1 FOS ZNF600 CSF2RA IL3RA ASMTL AKAP17A ASMT P2RY8 SLC25A6 CRLF2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL3RA on UCSC Golden Path with GeneCards custom track

Promoters for IL3RA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001555697 413 1201 TBP ZNF146 ZNF280D CEBPB CHD4 ASH2L EBF1 MNT POLR2A IKZF1

Genomic Location for IL3RA Gene

1,336,587 bp from pter
1,382,689 bp from pter
46,103 bases
Plus strand

Genomic View for IL3RA Gene

Genes around IL3RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL3RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL3RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL3RA Gene

Proteins for IL3RA Gene

  • Protein details for IL3RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-3 receptor subunit alpha
    Protein Accession:
    Secondary Accessions:
    • A8K3F3
    • B9VI81
    • Q5HYQ7
    • Q5HYQ8
    • Q9UEH7

    Protein attributes for IL3RA Gene

    378 amino acids
    Molecular mass:
    43330 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
    • Sequence=BAA08393.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL3RA Gene

    Alternative splice isoforms for IL3RA Gene


neXtProt entry for IL3RA Gene

Post-translational modifications for IL3RA Gene

  • Glycosylation at Asn 46, Asn 64, Asn 80, Asn 109, Asn 212, and Asn 218
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for IL3RA (IL-3 R alpha/CD123)
  • Cloud-Clone Corp. Antibodies for IL3RA

No data available for DME Specific Peptides for IL3RA Gene

Domains & Families for IL3RA Gene

Suggested Antigen Peptide Sequences for IL3RA Gene

Graphical View of Domain Structure for InterPro Entry



  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
genes like me logo Genes that share domains with IL3RA: view

Function for IL3RA Gene

Molecular function for IL3RA Gene

UniProtKB/Swiss-Prot Function:
This is a receptor for interleukin-3.

Gene Ontology (GO) - Molecular Function for IL3RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004896 cytokine receptor activity IEA --
GO:0004912 interleukin-3 receptor activity TAS 1833064
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with IL3RA: view
genes like me logo Genes that share phenotypes with IL3RA: view

Human Phenotype Ontology for IL3RA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IL3RA Gene

Localization for IL3RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL3RA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL3RA gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
endoplasmic reticulum 1
cytosol 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for IL3RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL3RA: view

Pathways & Interactions for IL3RA Gene

SuperPathways for IL3RA Gene

SuperPathway Contained pathways
1 RET signaling
2 PEDF Induced Signaling
3 TGF-Beta Pathway
4 Akt Signaling
5 G beta-gamma signalling through PI3Kgamma
genes like me logo Genes that share pathways with IL3RA: view

SIGNOR curated interactions for IL3RA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL3RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0036016 cellular response to interleukin-3 IEA --
GO:0038156 interleukin-3-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with IL3RA: view

Drugs & Compounds for IL3RA Gene

(8) Drugs for IL3RA Gene - From: DrugBank, DGIdb, FDA Approved Drugs, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sargramostim Approved, Investigational Pharma Target, agonist 0
Leukine Approved on November 24, 1995/ Approved November 1996 Pharma 0
IL-3 Pharma Agonist 0
CSL 360 Pharma 0

(5) Additional Compounds for IL3RA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL3RA: view

Transcripts for IL3RA Gene

Unigene Clusters for IL3RA Gene

Interleukin 3 receptor, alpha (low affinity):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL3RA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP3: - -

Relevant External Links for IL3RA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL3RA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL3RA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IL3RA Gene

This gene is overexpressed in Gallbladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL3RA Gene

Protein tissue co-expression partners for IL3RA Gene

NURSA nuclear receptor signaling pathways regulating expression of IL3RA Gene:


SOURCE GeneReport for Unigene cluster for IL3RA Gene:

genes like me logo Genes that share expression patterns with IL3RA: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IL3RA Gene

Orthologs for IL3RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL3RA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL3RA 34
  • 84.22 (n)
(Canis familiaris)
Mammalia IL3RA 34 35
  • 63.8 (n)
(Bos Taurus)
Mammalia IL3RA 34
  • 58.95 (n)
(Mus musculus)
Mammalia Il3ra 34 16 35
  • 48.29 (n)
(Rattus norvegicus)
Mammalia Il3ra 34
  • 47.93 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 26 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 23 (a)
(Gallus gallus)
Aves -- 35
  • 23 (a)
-- 35
  • 21 (a)
Species where no ortholog for IL3RA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL3RA Gene

Gene Tree for IL3RA (if available)
Gene Tree for IL3RA (if available)

Paralogs for IL3RA Gene

Paralogs for IL3RA Gene

(1) SIMAP similar genes for IL3RA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IL3RA: view

Variants for IL3RA Gene

Sequence variations from dbSNP and Humsavar for IL3RA Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10624984 -- 1,353,664(+) TGGGA(-/C/CC)CCCCC intron-variant
rs111066021 -- 1,355,041(+) GGAAG(A/G)GGAGC intron-variant
rs111161737 -- 1,359,967(+) TCTGT(A/G)TCTCT intron-variant, upstream-variant-2KB
rs111161739 -- 1,360,240(+) TCTGT(A/G)TCTCT intron-variant, upstream-variant-2KB
rs111162406 -- 1,360,015(+) TCTCT(A/C)TCTTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IL3RA Gene

Variant ID Type Subtype PubMed ID
nsv820760 CNV deletion 20802225
nsv1153650 CNV duplication 26484159
nsv1145298 CNV deletion 24896259
nsv1144310 CNV deletion 24896259
nsv1137684 CNV deletion 24896259
nsv1115920 CNV duplication 24896259
nsv1115919 CNV duplication 24896259
nsv1110637 CNV duplication 24896259
nsv1077212 CNV deletion 25765185
nsv1076292 CNV deletion 25765185
nsv1076238 CNV deletion 25765185
esv3558483 CNV deletion 23714750
esv3558482 CNV deletion 23714750
esv3558481 CNV deletion 23714750
esv3558480 CNV deletion 23714750
esv29996 CNV loss 17803354
esv2739697 CNV deletion 23290073
esv2739694 CNV deletion 23290073
esv2739693 CNV deletion 23290073
esv2739685 CNV deletion 23290073
esv2739683 CNV deletion 23290073
esv2739682 CNV deletion 23290073
esv2739681 CNV deletion 23290073
esv2739680 CNV deletion 23290073
esv2739679 CNV deletion 23290073
esv2739678 CNV deletion 23290073
esv2673745 CNV deletion 23128226
esv2670115 CNV deletion 23128226
esv2666429 CNV deletion 23128226
esv2663551 CNV deletion 23128226
esv2661406 CNV deletion 23128226
esv2656955 CNV deletion 23128226
esv21933 CNV gain+loss 19812545
esv2166277 CNV deletion 18987734
dgv1300e201 CNV deletion 23290073
dgv1299e201 CNV deletion 23290073

Variation tolerance for IL3RA Gene

Residual Variation Intolerance Score: 75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL3RA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL3RA Gene

Disorders for IL3RA Gene

MalaCards: The human disease database

(8) MalaCards diseases for IL3RA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hairy cell leukemia
  • hcl-v
acute basophilic leukemia
blastic plasmacytoid dendritic cell
  • blastic nk-cell lymphoma
hematologic cancer
  • blood cancer
infiltrating lipoma
  • intramuscular lipoma
- elite association - COSMIC cancer census association via MalaCards
Search IL3RA in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL3RA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IL3RA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL3RA Gene

Publications for IL3RA Gene

  1. A new isoform of IL-3 receptor alpha with novel differentiation activity and high affinity binding mode. (PMID: 19109256) Chen J. … Young I.G. (J. Biol. Chem. 2009) 3 4 22 64
  2. A family-based study of the IL3RA gene on susceptibility to schizophrenia in a Chinese Han population. (PMID: 19281803) Sun S. … Zhang X.Y. (Brain Res. 2009) 3 22 46 64
  3. Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population. (PMID: 18547720) Sun S. … Zhang X.Y. (Neurosci. Lett. 2008) 3 22 46 64
  4. Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. (PMID: 17522711) Lencz T. … Malhotra A.K. (Mol. Psychiatry 2007) 3 22 46 64
  5. Structure of the gene encoding the alpha subunit of the human interleukin 3 receptor. (PMID: 7887951) Kosugi H. … Yokota T. (Biochem. Biophys. Res. Commun. 1995) 3 4 22 64

Products for IL3RA Gene

Sources for IL3RA Gene

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