Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IL3RA Gene

protein-coding   GIFtS: 65
GCID: GC0XP001455

Interleukin 3 Receptor, Alpha (Low Affinity)

  See IL3RA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Interleukin 3 Receptor, Alpha (Low Affinity)1 2     CD1232
IL-3R-alpha2 3     IL3RAY2
IL-3RA2 3     IL3RX2
IL3R2 3     IL3RY2
CD123 Antigen2 3     hIL-3Ra2
IL-3 Receptor Subunit Alpha2 3     IL-3 Receptor Alpha SP2 Isoform2
IL-3R Subunit Alpha2 3     Interleukin-3 Receptor Subunit Alpha2

External Ids:    HGNC: 60121   Entrez Gene: 35632   Ensembl: ENSG000001852917   OMIM: 308385,4300005   UniProtKB: P269513   

Export aliases for IL3RA gene to outside databases

Previous GC identifers: GC00U990171 GC0YU900011 GC0XP9H0000 GC0YP001499 GC0XP001499 GC0XP001415


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for IL3RA Gene:
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The
receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the
receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The
binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding,
and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating
factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on
chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.
(provided by RefSeq, Jun 2012)

GeneCards Summary for IL3RA Gene:
IL3RA (interleukin 3 receptor, alpha (low affinity)) is a protein-coding gene. Diseases associated with IL3RA include cd4+/cd56+ hematodermic neoplasm, and acute basophilic leukemia. GO annotations related to this gene include interleukin-3 receptor activity. An important paralog of this gene is CSF2RA.

UniProtKB/Swiss-Prot: IL3RA_HUMAN, P26951
Function: This is a receptor for interleukin-3

Gene Wiki entry for IL3RA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000023.11  NT_187358.1  NC_000024.10  NT_167201.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL3RA gene promoter:
         STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL3RA promoter sequence
   Search Chromatin IP Primers for IL3RA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL3RA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.3 or Yp11.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.3 and Yp13.3

IL3RA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL3RA gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP001455:  view genomic region     (about GC identifiers)

Start:
1,455,509 bp from pter      End:
1,501,582 bp from pter
Size:
46,074 bases      Orientation:
plus strand

1 alternative location:
ChrY+ 1,405,509-1,451,582     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IL3RA_HUMAN, P26951 (See protein sequence)
Recommended Name: Interleukin-3 receptor subunit alpha precursor  
Size: 378 amino acids; 43330 Da
Subunit: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF
receptors
Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes
Secondary accessions: A8K3F3 B9VI81 Q5HYQ7
Alternative splicing: 2 isoforms:  P26951-1   P26951-2   

Explore the universe of human proteins at neXtProt for IL3RA: NX_P26951

Explore proteomics data for IL3RA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn46, Asn64, Asn80, Asn109, Asn212, Asn218
  • Modification sites at PhosphoSitePlus

  • See IL3RA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001254642.1  NP_002174.1  

    ENSEMBL proteins: 
     ENSP00000327890   ENSP00000414867   ENSP00000370878  
    Reactome Protein details: P26951

    IL3RA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL3RA (IL-3 R alpha/CD123)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IL3RA
    OriGene Protein Over-expression Lysate for IL3RA
    OriGene MassSpec for IL3RA
    OriGene Custom Protein Services for IL3RA
    GenScript Custom Purified and Recombinant Proteins Services for IL3RA
    Novus Biologicals IL3RA Proteins
    Novus Biologicals IL3RA Lysates
    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for IL3RA
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IL3RA 

    IL3RA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL3RA
    R&D Systems Antibodies for IL3RA (IL-3 R alpha/CD123)
    OriGene Antibodies for IL3RA
    OriGene Custom Antibody Services for IL3RA
    Novus Biologicals IL3RA Antibodies
    Abcam antibodies for IL3RA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for IL3RA
    LSBio Antibodies in human, mouse, rat for IL3RA

    IL3RA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL3RA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IL3RA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for IL3RA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    PAR1: Pseudoautosomal regions / PAR1
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 3 receptor, alpha subunit
    IL-3 receptor family

    4 InterPro protein domains:
     IPR015321 IL-6_rcpt_alpha-bd
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR003532 Short_hematopoietin_rcpt_2_CS

    Graphical View of Domain Structure for InterPro Entry P26951

    ProtoNet protein and cluster: P26951

    1 Blocks protein domain: IPB003532 Short hematopoietin receptor

    UniProtKB/Swiss-Prot: IL3RA_HUMAN, P26951
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Domain: The box 1 motif is required for JAK interaction and/or activation
    Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily


    Find genes that share domains with IL3RA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL3RA_HUMAN, P26951
    Function: This is a receptor for interleukin-3

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004896cytokine receptor activity ----
    GO:0004912interleukin-3 receptor activity TAS1833064
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IL3RA           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IL3RA:
     Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL3RA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL3RA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL3RA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL3RA

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat IL3RA using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IL3RA
    SwitchGear 3'UTR luciferase reporter plasmidIL3RA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL3RA
    Predesigned siRNA for gene silencing in human, mouse, rat IL3RA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL3RA

    Clone
    Products:
         
    OriGene clones in human, mouse for IL3RA (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL3RA (NM_002183)
    Sino Biological Human cDNA Clone for IL3RA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL3RA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL3RA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL3RA
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL3RA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL3RA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IL3RA_HUMAN, P26951: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with IL3RA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for IL3RA About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    PGC1Alpha Pathway0.51
    Glucocorticoid Receptor Signaling0.43
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    2TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51
    3Signaling by Interleukins
    Interleukin receptor SHC signaling0.67
    Interleukin-3, 5 and GM-CSF signaling0.59
    Interleukin-2 signaling0.67
    Signaling by Interleukins0.42
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5p70S6K Signaling
    p70S6K Signaling0.60


    Find genes that share SuperPaths with IL3RA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL3RA (see all 15)
        MSP-RON Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Glucocorticoid Receptor Signaling

    1 GeneGo (Thomson Reuters) Pathway for IL3RA
        Immune response IL-3 activation and signaling pathway

    1 BioSystems Pathway for IL3RA
        IL-3 Signaling Pathway


    2 Reactome Pathways for IL3RA
        Interleukin receptor SHC signaling
    Interleukin-3, 5 and GM-CSF signaling


    5 Kegg Pathways  (Kegg details for IL3RA):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Apoptosis
    Jak-STAT signaling pathway
    Hematopoietic cell lineage

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL3RA: 
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL3RA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL3RA (P269512, 3 ENSP000003278904) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062412, 3, ENSP000003576564MINT-8111307 I2D: score=3 STRING: ENSP00000357656
    PLCG1P191742, 3, ENSP000002440074MINT-8112603 I2D: score=3 STRING: ENSP00000244007
    IL3P087003, ENSP000002968704I2D: score=4 STRING: ENSP00000296870
    CSF2RBP329273, ENSP000003840534I2D: score=3 STRING: ENSP00000384053
    CISHQ9NSE23, ENSP000004093464I2D: score=2 STRING: ENSP00000409346
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0036016cellular response to interleukin-3 TAS1833064
    GO:0038156interleukin-3-mediated signaling pathway TAS1833064

    Find genes that share ontologies with IL3RA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL3RA

    1 DrugBank Compound for IL3RA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    SargramostimColony-stimulating factor (see all 5)83869-56-1targetagonist17562355 17500228 16698686 17522711

    1 IUPHAR Ligand for IL3RA (Interleukin 3 receptor, alpha subunit)    About this table
    LigandTypeActionAffinityPubmed IDs
    IL-3
    AgonistAgonist--

    9 Novoseek inferred chemical compound relationships for IL3RA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 60.2 10 10068651 (3), 9389693 (3), 9890661 (1), 10414448 (1)
    tyrosine 43.5 16 10068651 (3), 7836750 (2), 2166606 (1), 15370201 (1) (see all 9)
    12-o-tetradecanoylphorbol 13-acetate 10.2 2 1290964 (1)
    glyceraldehyde 3-phosphate 10.1 1 7521187 (1)
    phosphatidylinositol 3.42 1 8939907 (1)
    thymidine 0 2 10764142 (1)
    threonine 0 1 8939907 (1)
    zinc 0 1 14527952 (1)
    phosphatidylcholine 0 2 7836750 (2)



    Find genes that share compounds with IL3RA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IL3RA gene (2 alternative transcripts): 
    NM_001267713.1  NM_002183.3  

    Unigene Cluster for IL3RA:

    Interleukin 3 receptor, alpha (low affinity)
    Hs.632790  [show with all ESTs]
    Unigene Representative Sequence: BC035407
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331035(uc004cps.3 uc011mhd.2) ENST00000432757 ENST00000381469

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IL3RA using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IL3RA
    SwitchGear 3'UTR luciferase reporter plasmidIL3RA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IL3RA
    Predesigned siRNA for gene silencing in human, mouse, rat IL3RA
    Clone
    Products:
         
    OriGene clones in human, mouse for IL3RA (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL3RA (NM_002183)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL3RA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL3RA
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IL3RA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL3RA
      QuantiTect SYBR Green Assays in human, mouse, rat IL3RA
      QuantiFast Probe-based Assays in human, mouse, rat IL3RA

    Additional mRNA sequence: 

    AK290568.1 BC035407.1 FJ550347.1 M74782.1 

    16 DOTS entries:

    DT.106458  DT.92423313  DT.92423314  DT.75184774  DT.100714210  DT.120652906  DT.120652854  DT.121315092 
    DT.121315254  DT.91696537  DT.97773494  DT.97817809  DT.102822929  DT.121315257  DT.91753594  DT.95247724 

    Selected AceView cDNA sequences (see all 50):

    AW452270 CD368847 BF856898 AI379750 BX507032 BC035407 BM921786 AI379730 
    BQ711484 BQ005358 BI910175 M74782 NM_002183 CB528608 BI772564 BM704769 
    BM693915 BU739504 CD364754 BM906431 BM921361 AI806887 AA722359 BV178340 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IL3RA    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                    -     -                                                         


    ECgene alternative splicing isoforms for IL3RA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IL3RA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAAGTGAT
    IL3RA Expression
    About this image


    IL3RA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Plasmacytoid Dendritic cells Peripheral Blood
             Facilitating cells
             cd31+ cells   
     
     Endothelium (Cardiovascular System)
             cd31+ cells   
    IL3RA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL3RA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632790
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL3RA: 
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IL3RA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL3RA
    QuantiTect SYBR Green Assays in human, mouse, rat IL3RA
    QuantiFast Probe-based Assays in human, mouse, rat IL3RA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL3RA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for IL3RA gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il3ra1 interleukin 3 receptor, alpha chain 48.29(n)
    33.73(a)
      16188  NM_008369.1  NP_032395.1 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    23(a)
    21(a)
    many ↔ many
    many ↔ many
    1(128513719-128552404)
    1(128555844-128567011)


    ENSEMBL Gene Tree for IL3RA (if available)
    TreeFam Gene Tree for IL3RA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IL3RA gene
    CSF2RA2  
    1 SIMAP similar gene for IL3RA using alignment to 3 protein entries:     IL3RA_HUMAN (see all proteins):
    CSF2RA

    Find genes that share paralogs with IL3RA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    4 SNPs for IL3RA    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs178833661,2,4
    ----see VAR_0211162 mis40--------
    rs178867561,2,4
    ----see VAR_0211142 mis40--------
    rs66470041,2,4
    ----see VAR_0211132 mis40--------
    rs178835721,2,4
    ----see VAR_0211152 mis40--------

    HapMap Linkage Disequilibrium report for IL3RA (1455509 - 1501582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IL3RA (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670115CNV Deletion23128226
    esv2739693CNV Deletion23290073
    esv2656955CNV Deletion23128226
    esv2739683CNV Deletion23290073
    esv2663551CNV Deletion23128226
    dgv1358e201CNV Deletion23290073
    esv2166277CNV Deletion18987734
    esv2739694CNV Deletion23290073
    esv2739681CNV Deletion23290073
    esv2739682CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL3RA
    DNA2.0 Custom Variant and Variant Library Synthesis for IL3RA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 308385,430000    OMIM disorders: --

    6 diseases for IL3RA:    
    About MalaCards
    cd4+/cd56+ hematodermic neoplasm    acute basophilic leukemia    blastic plasmacytoid dendritic cell    burns
    acute leukemia    acute myeloid leukemia


    Find genes that share disorders with IL3RA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL3RA gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diphtheria 49.3 5 11368443 (1), 15003313 (1), 15928038 (1), 16882709 (1) (see all 5)
    acute leukemia 49 6 11726317 (2), 12950240 (1), 11021753 (1), 14671644 (1) (see all 5)
    myeloid leukemia 44 2 10764142 (1)
    leukemia 39.4 12 15003313 (2), 17667524 (2), 8547680 (1), 20064159 (1) (see all 5)
    leukemia hairy cell 31.3 7 11726317 (2), 15020268 (1)
    hematologic malignancies 24.7 3 11726317 (2)
    lymphoblastic leukemia acute 10.4 3 17205058 (1), 11726317 (1), 10720134 (1)
    necrosis 9.03 5 7687890 (1), 7545455 (1), 18552348 (1), 1825289 (1) (see all 5)
    hodgkin disease 8.87 1 12507919 (1)
    leukemia lymphocytic chronic 7.95 5 11726317 (1)

    Genetic Association Database (GAD): IL3RA
    Human Genome Epidemiology (HuGE) Navigator: IL3RA (6 documents)

    Export disorders for IL3RA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IL3RA gene, integrated from 10 sources (see all 193):
    (articles sorted by number of sources associating them with IL3RA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. (PubMed id 17522711)1, 4, 7, 9 Lencz T....Malhotra A.K. (Mol. Psychiatry 2007)
    2. Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors. (PubMed id 1833064)1, 2, 3 Kitamura T.... Miyajima A. (Cell 1991)
    3. A family-based study of the IL3RA gene on susceptibility to schizophrenia in a Chinese Han population. (PubMed id 19281803)1, 4, 9 Sun S....Zhang X.Y. (Brain Res. 2009)
    4. Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population. (PubMed id 18547720)1, 4, 9 Sun S....Zhang X.Y. (Neurosci. Lett. 2008)
    5. A new isoform of IL-3 receptor alpha with novel differentiation activity and high affinity binding mode. (PubMed id 19109256)1, 2, 9 Chen J....Young I.G. (J. Biol. Chem. 2009)
    6. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    7. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    8. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis. (PubMed id 12351411)1, 9 Testa U....Peschle C. (Blood 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3563 HGNC: 6012 AceView: IL3RA Ensembl:ENSG00000185291 euGenes: HUgn3563
    ECgene: IL3RA Kegg: 3563 H-InvDB: IL3RA

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IL3RA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL3RA Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/il3ra/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IL3RA gene:
    Search GeneIP for patents involving IL3RA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of IL3RA
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for IL3RA (IL-3 R alpha/CD123)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for IL3RA (IL-3 R alpha/CD123)   Browse Stem Cell Products  
     cDNA Clones for IL3RA (IL-3 R alpha/CD123)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for IL3RA   OriGene RNAi products in human, mouse, rat for IL3RA  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for IL3RA  
     OriGene MassSpec something-or-other for IL3RA   OriGene clones in human, mouse for IL3RA  
     OriGene qSTAR qPCR primer pairs in human, mouse for IL3RA   OriGene Purified Protein for IL3RA  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IL3RA   OriGene Custom Protein Services for IL3RA  

     
     
     Block miRNA regulation of human, mouse, rat IL3RA using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IL3RA
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL3RA Predesigned siRNA for gene silencing in human, mouse, rat IL3RA
     QuantiFast Probe-based Assays in human, mouse, rat IL3RA QuantiTect SYBR Green Assays in human, mouse, rat IL3RA
     PCR Arrays including human, mouse, rat IL3RA Search Chromatin IP Primers for IL3RA
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL3RA  GeneGlobe Interaction Network for IL3RA
     Regulatory tfbs in IL3RA promoter
     GenScript Custom Purified and Recombinant Proteins Services for IL3RA GenScript cDNA clones with any tag delivered in your preferred vector for IL3RA
     GenScript Custom Assay Services for IL3RA GenScript Custom overexpressing Cell Line Services for IL3RA
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IL3RA
     Browse Sino Biological Proteins
     Cell Lysates for IL3RA
     cDNA Clones for IL3RA
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IL3RA antibodies
     IL3RA proteins
     IL3RA lysates
     Antibodies for IL3RA
     See all of Abcam's Antibodies, Kits and Proteins for IL3RA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for IL3RA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL3RA
     SwitchGear 3'UTR luciferase reporter plasmids for IL3RA
     SwitchGear Promoter luciferase reporter plasmids for IL3RA
     ThermoFisher Antibodies for IL3RA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL3RA
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL3RA
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL3RA
     LSBio Antibodies in human, mouse, rat for IL3RA
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for IL3RA
      Search eBioscience for proteins for IL3RA
      Search eBioscience for elisas for IL3RA
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IL3RA gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4