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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL37 Gene

protein-coding   GIFtS: 47
GCID: GC02P113672

interleukin 37

(Previous names: interleukin 1 family, member 7 (zeta) )
(Previous symbol: IL1F7)
 Explore 11 diseases affiliated with
IL37 via
MalaCards
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 Human Malady Compendium 
Biological research products
for IL37    

Aliases
for IL37 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interleukin 371 2     IL-1 Zeta2 3
FIL1Z1 2 3 5     Interleukin 1 Family, Member 7 (Zeta)1
IL1F71 2 3 5     IL-1F7b (IL-1H4, IL-1H, IL-1RP1)2
IL-1F71 2 3     IL-1X Protein2
IL-1H41 2 3     IL1F7 (Canonical Product IL-1F7b)2
IL-1RP11 2 3     Interleukin 1 Family Member 72
IL1H42 3 5     Interleukin 1, Zeta2
IL1RP12 3 5     Interleukin-1 Superfamily Z2
FIL11 2     Interleukin-233
FIL1(ZETA)1 2     Interleukin-371
Interleukin-1 Homolog 42 3     IL-1X3
Interleukin-1-Related Protein2 3     Interleukin-233
IL-1H2 3     Interleukin-1 Family Member 73
IL-372 3     Interleukin-1 Zeta3
FIL1 Zeta2 3     

External Ids:    HGNC: 155631   Entrez Gene: 271782   Ensembl: ENSG000001255717   OMIM: 6055105   UniProtKB: Q9NZH63   

Export aliases for IL37 gene to outside databases


Summaries
for IL37 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IL37:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may
be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein
(IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor
beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1
family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding
distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL37_HUMAN, Q9NZH6
Function: Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This
function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well
as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell
activation

Gene Wiki entry for IL37 (IL1F7)


Genomic Views
for IL37 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022135.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IL37
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL37 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL37

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12-q14.1   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q12-q14.1

IL37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL37 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P113672:  view genomic region     (about GC identifiers)

Start:
 113,670,548 bp from pter      End:
 113,676,459 bp from pter
Size:
 5,912 bases      Orientation:
 plus strand

Proteins
for IL37 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IL37_HUMAN, Q9NZH6 (See protein sequence)
Recommended Name: Interleukin-37 precursor  
Size: 218 amino acids; 24126 Da
Subunit: Interacts with SMAD3. Binds IL18R1, but not to IL1R1, with lower affinity than IL18, and does not seem to act
as a receptor antagonist for IL18
Subcellular location: Cytoplasm, cytosol. Nucleus. Secreted. Note=Stimulation with IL1B leads to colocalization with
SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS
stimulation
Secondary accessions: B5BU97 Q56AP9 Q8TD04 Q8TD05 Q9HBF2 Q9HBF3 Q9UHA6
Alternative splicing: 5 isoforms:  Q9NZH6-1   Q9NZH6-2   Q9NZH6-3   Q9NZH6-4   Q9NZH6-5   (The name IL-HL refers to isoform B containing polymorphisms Val-31 and Ala-42 (PubMed:11145836))

Explore the universe of human proteins at neXtProt for IL37: NX_Q9NZH6

Post-translational modifications:

  • Proteolytically converted to the mature form by CASP11
  • View neXtProt modification sites for NX_Q9NZH6

    • IL37 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_055254.2  NP_775294.1  NP_775295.1  NP_775296.1  NP_775297.1  

    ENSEMBL proteins: 
     ENSP00000263326   ENSP00000263327   ENSP00000263328   ENSP00000309208   ENSP00000309883  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: IL37
    OriGene Protein Over-expression Lysate (see all 2): IL37
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    Novus Biologicals IL37 Protein
    Novus Biologicals IL37 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for IL37
    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS10744718
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--
    GO:0005829cytosol IEA--


    IL37 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for IL37 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IL37 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR003297 IL-1RA/IL-36
     IPR008996 Cytokine_IL1-like
     IPR027169 Interleukin-37
     IPR000975 Interleukin_1

    Graphical View of Domain Structure for InterPro Entry Q9NZH6

    ProtoNet protein and cluster: Q9NZH6

    1 Blocks protein family: IPB000975 Interleukin-1 precursor family signature

    UniProtKB/Swiss-Prot: IL37_HUMAN, Q9NZH6
    Similarity: Belongs to the IL-1 family


    Function
    for IL37 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IL37_HUMAN, Q9NZH6
    Function: Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This
    function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well
    as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell
    activation
    Induction: Highly induced by bacterial lipopolysaccharides (LPS) and TGFB1, more moderately by IFNG, IL18, IL1B, TNF
    and the dinucleotide CpG (at protein level). Constitutive expression in bone marrow macrophages is down-regulated in
    the presence of IL4 and CSF2. Induced by phorbol myristate acetate (PMA) in different cell lines

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL37
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    Inhib. RNA
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    OriGene shRNA RFP: IL37
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for IL37

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005149interleukin-1 receptor binding TAS10625660
    GO:0005152interleukin-1 receptor antagonist activity IEA--


    IL37 for ontologies           About GeneDecksing



    Pathways & Interactions
    for IL37 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL37

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for IL37 (Q9NZH62, 3 ENSP000002633264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3, ENSP000003329734MINT-51256 I2D: score=4 STRING: ENSP00000332973
    CASP4P496623, ENSP000003885664I2D: score=2 STRING: ENSP00000388566
    IL18BPO959983, ENSP000002600494I2D: score=1 STRING: ENSP00000260049
    CASP1P294663, ENSP000004100764I2D: score=2 STRING: ENSP00000410076
    IL18R1Q134783, ENSP000002339574I2D: score=3 STRING: ENSP00000233957
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS10744718


    IL37 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IL37 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL37
    Search CenterWatch for drugs/clinical trials and news about IL37 

    Transcripts
    for IL37 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IL37 gene (5 alternative transcripts): 
    NM_014439.3  NM_173202.1  NM_173203.1  NM_173204.1  NM_173205.1  

    Unigene Cluster for IL37:

    Interleukin 37
    Hs.166371  [show with all ESTs]
    Unigene Representative Sequence: AF200496
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263326(uc002tij.3) ENST00000352179(uc002tik.3) ENST00000349806(uc002tim.3)
    ENST00000353225(uc002til.3) ENST00000311328(uc002tin.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL37
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL37
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL37
    OriGene shRNA RFP: IL37
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL37

    Additional cDNA sequence: 

    AB451333.1 AB451478.1 AF167368.1 AF200496.1 AF201832.1 AF251119.1 AF251120.1 AY071840.1 
    AY071841.1 BC020637.1 

    5 DOTS entries:

    DT.40293707  DT.97835597  DT.92416674  DT.95157545  DT.97835596 

    18 AceView cDNA sequences:

    AF167368 AF201832 NM_014439 AI343258 AY071841 AF200496 NM_173203 AY071840 
    NM_173205 NM_173202 NM_173204 AF251120 BX283240 BC020637 AF251119 BG620449 
    AF251118 AI014548 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IL37    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                    -                           
    SP2:              -     -                           
    SP3:                                                
    SP4:              -     -     -                     
    SP5:                    -     -                     


    ECgene alternative splicing isoforms for IL37

    Expression
    for IL37 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL37 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IL37 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IL37 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL37

    SOURCE GeneReport for Unigene cluster: Hs.166371

    UniProtKB/Swiss-Prot: IL37_HUMAN, Q9NZH6
    Tissue specificity: In general, low constitutive expression, if any, in healthy tissues; high expression in
    inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A,
    isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were
    found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only
    isoform C in heart

        SABiosciences Expression via Pathway-Focused PCR Array including IL37: 
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    In Situ
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    Orthologs
    for IL37 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IL37 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 28(a)
    27(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 GL343238.1(843486-846613)
    GL343238.1(908975-910584)


    ENSEMBL Gene Tree for IL37 (if available)
    TreeFam Gene Tree for IL37 (if available) 

    Paralogs
    for IL37 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL37 gene
    IL36A2  IL1RN2  IL36RN2  IL36G2  IL1F102  
    2 SIMAP similar genes for IL37 using alignment to 1 protein entry:     IL37_HUMAN:
    IL36G    IL36A

    IL37 for paralogs           About GeneDecksing



    Genomic Variants
    for IL37 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/206 NCBI SNPs in IL37 are shown (see all 206)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs27231711,2
    		C,F,A,--106123329(-) GTGGTC/GTGTGG 4 -- us2k16Minor allele frequency- G:0.16WA NA 246
    rs27089661,2
    		C,F,A,--106123369(-) GCCAGT/CGCAGG 4 -- us2k1 tfbs36Minor allele frequency- C:0.16WA NA 246
    rs27089651,2
    		C,F,O,A,H,--106123604(-) GGGTTG/TGTGGA 4 -- us2k112Minor allele frequency- T:0.12NS EA NA WA 754
    rs289471841,2
    		C--106123607(+) ACCAAC/TCCTGG 4 -- us2k13Minor allele frequency- T:0.01NS NA 92
    rs27089641,2
    		C,F,A,--106123845(-) TGAAGG/AACAGA 4 -- us2k18Minor allele frequency- A:0.16NS NA WA 336
    rs27089631,2
    		C,F,O,A,--106123889(-) GAAACG/ATAGGT 4 -- us2k18Minor allele frequency- A:0.16NS NA WA 338
    rs27089621,2
    		C,F,O,A,H,--106124106(-) AGGACG/AGTGAG 4 -- us2k119Minor allele frequency- A:0.11NS EA NA WA 2060
    rs289471861,2
    		C,F,--106124155(+) TTTTTG/ACATGA 4 -- us2k1 tfbs34Minor allele frequency- A:0.09NS NA WA 214
    rs27089611,2
    		C,F,A,H,--106124351(-) CTTTCA/GACATC 4 -- us2k119Minor allele frequency- G:0.10NS EA NA WA 2064
    rs289471871,2
    		C,--106124475(+) TTGAGC/TCTCCT 4 -- us2k13Minor allele frequency- T:0.01NS NA 96

    HapMap Linkage Disequilibrium report for IL37 (113670548 - 113676459 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IL37: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL37
    DNA2.0 Custom Variant and Variant Library Synthesis for IL37

    Disorders / Diseases
    for IL37 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IL37 for disorders           About GeneDecksing

    OMIM gene information: 605510    OMIM disorders: --

    11 diseases for IL37:    About MalaCards
    ankylosing spondylitis    morbid obesity    acute lymphoblastic leukemia    lymphoblastic leukemia
    spondylitis    rheumatoid arthritis    hepatitis b    obesity
    arthritis    leukemia    hepatitis


    Export disorders for IL37 gene to outside databases

    Publications
    for IL37 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL37 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with IL37)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Four new members expand the IL-1 superfamily. (PubMed id 10625660)1, 2, 3, 9 Smith D.E....Sims J.E. (2000)
    2. The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines. (PubMed id 18390730)1, 2, 9 Sharma S....Bufler P. (2008)
    3. IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL- 1Rrp. (PubMed id 11145836)1, 2, 9 Pan G.... Vandlen R. (2001)
    4. IL-37 is a fundamental inhibitor of innate immunity. (PubMed id 20935647)1, 2 Nold M.F....Dinarello C.A. (2010)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Innate immunity mediated by the cytokine IL-1 homolog ue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor im munity. (PubMed id 12496389)1, 3 Gao W....Gambotto A. (2003)
    8. Genomic organization of the interleukin-1 locus. (PubMed id 11991723)1, 2 Taylor S.L....Sims J.E. (2002)
    9. Identification and initial characterization of four novel members of the interleukin-1 family. (PubMed id 10744718)1, 2 Kumar S....Young P.R. (2000)
    10. IL1HY1: A novel interleukin-1 receptor antagonist gene. (PubMed id 10512743)1, 3 Mulero J.J....Ford J.E. (1999)

    External Searches for IL37 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing IL37 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27178 HGNC: 15563 AceView: IL1F7 Ensembl:ENSG00000125571 euGenes: HUgn27178
    ECgene: IL37 H-InvDB: IL37

    Other Databases showing IL37 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IL37 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL37 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
    SeattleSNPshttp://pga.gs.washington.edu/data/il1f7/

    Intellectual Property
    for IL37 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IL37 gene:
    Search GeneIP for patents involving IL37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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