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IL37 Gene

protein-coding   GIFtS: 49
GCID: GC02P113672

Interleukin 37

(Previous names: interleukin 1 family, member 7 (zeta))
(Previous symbol: IL1F7)
  See IL37-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 371 2     zeta1
IL1F71 2 3 5     FIL12
Interleukin-1 Homolog 41 2 3     FIL1(ZETA)2
Interleukin-1-Related Protein1 2 3     IL-1F7b (IL-1H4, IL-1H, IL-1RP1)2
FIL1Z2 3 5     IL-1X Protein2
IL1H42 3 5     IL1F7 (Canonical Product IL-1F7b)2
IL1RP12 3 5     Interleukin 1 Family Member 72
IL-1F72 3     Interleukin 1, Zeta2
IL-1H2 3     Interleukin-1 Superfamily Z2
IL-1H42 3     interleukin-232
IL-1RP12 3     interleukin-372
IL-372 3     IL-1X3
FIL1 Zeta2 3     Interleukin-233
IL-1 Zeta2 3     Interleukin-1 Family Member 73
Interleukin 11     Interleukin-1 Zeta3
Interleukin 1 Family, Member 7 (Zeta)1     

External Ids:    HGNC: 155631   Entrez Gene: 271782   Ensembl: ENSG000001255717   OMIM: 6055105   UniProtKB: Q9NZH63   

Export aliases for IL37 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL37 Gene:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and
may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding
protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with
IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other
interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript
variants encoding distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL37 Gene:
IL37 (interleukin 37) is a protein-coding gene. Diseases associated with IL37 include morbid obesity. GO annotations related to this gene include interleukin-1 receptor binding and cytokine activity. An important paralog of this gene is IL36A.

UniProtKB/Swiss-Prot: IL37_HUMAN, Q9NZH6
Function: Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This
function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as
well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits
dendritic cell activation

Gene Wiki entry for IL37 (IL1F7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IL37
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL37 promoter sequence
   Search Chromatin IP Primers for IL37

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12-q14.1   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q12-q14.1

IL37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL37 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P113672:  view genomic region     (about GC identifiers)

Start:
113,670,548 bp from pter      End:
113,676,459 bp from pter
Size:
5,912 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL37_HUMAN, Q9NZH6 (See protein sequence)
Recommended Name: Interleukin-37 precursor  
Size: 218 amino acids; 24126 Da
Subunit: Interacts with SMAD3. Binds IL18R1, but not to IL1R1, with lower affinity than IL18, and does not seem to
act as a receptor antagonist for IL18
Secondary accessions: B5BU97 Q56AP9 Q8TD04 Q8TD05 Q9HBF2 Q9HBF3 Q9UHA6
Alternative splicing: 5 isoforms:  Q9NZH6-1   Q9NZH6-2   Q9NZH6-3   Q9NZH6-4   Q9NZH6-5   (The name IL-HL refers to isoform B containing polymorphisms Val-31 and Ala-42 (PubMed:11145836))

Explore the universe of human proteins at neXtProt for IL37: NX_Q9NZH6

Explore proteomics data for IL37 at MOPED

Post-translational modifications: 

  • Proteolytically converted to the mature form by CASP11
  • Modification sites at neXtProt

  • See IL37 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_055254.2  NP_775294.1  NP_775295.1  NP_775296.1  NP_775297.1  

    ENSEMBL proteins: 
     ENSP00000263326   ENSP00000263327   ENSP00000263328   ENSP00000309208   ENSP00000309883  

    IL37 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for IL37
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    Novus Biologicals IL37 Protein
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    Sino Biological Recombinant Protein for IL37
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    Search eBioscience for ELISAs for IL37 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    4 InterPro protein domains:
     IPR003297 IL-1RA/IL-36
     IPR027169 IL-37
     IPR000975 IL-1
     IPR008996 Cytokine_IL1-like

    Graphical View of Domain Structure for InterPro Entry Q9NZH6

    ProtoNet protein and cluster: Q9NZH6

    1 Blocks protein domain: IPB000975 Interleukin-1 precursor family signature

    UniProtKB/Swiss-Prot: IL37_HUMAN, Q9NZH6
    Similarity: Belongs to the IL-1 family


    Find genes that share domains with IL37           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL37_HUMAN, Q9NZH6
    Function: Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This
    function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as
    well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits
    dendritic cell activation
    Induction: Highly induced by bacterial lipopolysaccharides (LPS) and TGFB1, more moderately by IFNG, IL18, IL1B,
    TNF and the dinucleotide CpG (at protein level). Constitutive expression in bone marrow macrophages is
    down-regulated in the presence of IL4 and CSF2. Induced by phorbol myristate acetate (PMA) in different cell
    lines

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005149interleukin-1 receptor binding TAS10625660
         
    Find genes that share ontologies with IL37           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL37
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL37

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL37
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL37

    miRNA
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    miRTarBase miRNAs that target IL37:
    hsa-mir-335-5p (MIRT016962)

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL37
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL37

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    Browse ESI BIO Cell Lines and PureStem Progenitors for IL37 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL37


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL37_HUMAN, Q9NZH6: Cytoplasm, cytosol. Nucleus. Secreted. Note=Stimulation with IL1B leads to colocalization
    with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon
    LPS stimulation

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS10744718
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--
    GO:0005829cytosol IEA--

    Find genes that share ontologies with IL37           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL37 About    
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    IL-1 Family Signaling Pathways0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL37
        IL-1 Family Signaling Pathways




        Pathway & Disease-focused RT2 Profiler PCR Array including IL37: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IL37

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for IL37 (Q9NZH62, 3 ENSP000002633264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3, ENSP000003329734MINT-51256 I2D: score=4 STRING: ENSP00000332973
    CASP4P496623, ENSP000003885664I2D: score=2 STRING: ENSP00000388566
    IL18BPO959983, ENSP000002600494I2D: score=1 STRING: ENSP00000260049
    CASP1P294663, ENSP000004100764I2D: score=2 STRING: ENSP00000410076
    IL18R1Q134783, ENSP000002339574I2D: score=3 STRING: ENSP00000233957
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0006955immune response NAS10625660

    Find genes that share ontologies with IL37           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL37



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL37 gene (5 alternative transcripts): 
    NM_014439.3  NM_173202.1  NM_173203.1  NM_173204.1  NM_173205.1  

    Unigene Cluster for IL37:

    Interleukin 37
    Hs.166371  [show with all ESTs]
    Unigene Representative Sequence: AF200496
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263326(uc002tij.3) ENST00000352179(uc002tik.3) ENST00000349806(uc002tim.3)
    ENST00000353225(uc002til.3) ENST00000311328(uc002tin.3)
    miRNA
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    Primer
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    OriGene qPCR primer pairs and template standards for IL37
    OriGene qSTAR qPCR primer pairs in human, mouse for IL37
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IL37
      QuantiTect SYBR Green Assays in human, mouse, rat IL37
      QuantiFast Probe-based Assays in human, mouse, rat IL37

    Additional mRNA sequence: 

    AB451333.1 AB451478.1 AF167368.1 AF200496.1 AF201832.1 AF251119.1 AF251120.1 AY071840.1 
    AY071841.1 BC020637.1 

    5 DOTS entries:

    DT.40293707  DT.97835597  DT.92416674  DT.95157545  DT.97835596 

    18 AceView cDNA sequences:

    AF200496 NM_173205 AY071840 NM_014439 AF201832 AY071841 AF167368 NM_173202 
    NM_173203 NM_173204 AI343258 AF251119 AF251120 BX283240 BC020637 BG620449 
    AF251118 AI014548 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IL37    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                    -                           
    SP2:              -     -                           
    SP3:                                                
    SP4:              -     -     -                     
    SP5:                    -     -                     


    ECgene alternative splicing isoforms for IL37

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL37 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IL37 Expression
    About this image

    IL37 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL37 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.166371

    UniProtKB/Swiss-Prot: IL37_HUMAN, Q9NZH6
    Tissue specificity: In general, low constitutive expression, if any, in healthy tissues; high expression in
    inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis.
    Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and
    isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in
    kidney and only isoform C in heart

        Pathway & Disease-focused RT2 Profiler PCR Array including IL37: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat IL37
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL37

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL37 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia IL371 interleukin 37 81.38(n)
    72.3(a)
      100686057  XM_005630448.1  XP_005630505.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    27(a)
    27(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343238.1(908975-910584)
    GL343238.1(840452-848403)


    ENSEMBL Gene Tree for IL37 (if available)
    TreeFam Gene Tree for IL37 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL37 gene
    IL36A2  IL36B2  IL1RN2  IL36RN2  IL1F102  IL36G2  
    2 SIMAP similar genes for IL37 using alignment to 1 protein entry:     IL37_HUMAN:
    IL36G    IL36A

    Find genes that share paralogs with IL37           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL37 (see all 268)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs27231721,2
    C,F,O,A,H--113182178(-) GCCAAA/CGGTAT 4 -- us2k125Minor allele frequency- C:0.11NS EA NA WA CSA 1872
    rs1813385821,2
    --113182301(+) AATGAA/GTACCA 4 -- us2k10--------
    rs27231711,2
    C,F,A--113182382(-) GTGGTC/GTGTGG 4 -- us2k16Minor allele frequency- G:0.16WA NA 246
    rs27089661,2
    C,F,A--113182422(-) GCCAGT/CGCAGG 4 -- us2k1 tfbs36Minor allele frequency- C:0.16WA NA 246
    rs1868200181,2
    C--113182483(+) AGACCC/TTTGCT 4 -- us2k10--------
    rs1507302711,2
    --113182522(+) TTTCTA/TAATAT 4 -- us2k10--------
    rs1915843871,2
    --113182534(+) ATCTCG/TGAGAC 4 -- us2k10--------
    rs1390242891,2
    --113182635(+) AGGCAA/GACACT 4 -- us2k10--------
    rs27089651,2
    C,F,O,A,H--113182657(-) GGGTTG/TGTGGA 4 -- us2k112Minor allele frequency- T:0.12NS EA NA WA 754
    rs289471841,2
    C--113182660(+) ACCAAC/TCCTGG 4 -- us2k13Minor allele frequency- T:0.01NS NA 92

    HapMap Linkage Disequilibrium report for IL37 (113670548 - 113676459 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL37:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2879CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL37
    DNA2.0 Custom Variant and Variant Library Synthesis for IL37

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605510    OMIM disorders: --

    1 disease for IL37:    
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    morbid obesity


    Find genes that share disorders with IL37           About GenesLikeMe


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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL37 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with IL37)
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    1. Four new members expand the IL-1 superfamily. (PubMed id 10625660)1, 2, 3, 9 Smith D.E....Sims J.E. (J. Biol. Chem. 2000)
    2. The IL-1 family member 7b translocates to the nucleus and down- regulates proinflammatory cytokines. (PubMed id 18390730)1, 2, 9 Sharma S.... Bufler P. (J. Immunol. 2008)
    3. IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL- 1Rrp. (PubMed id 11145836)1, 2, 9 Pan G.... Vandlen R. (Cytokine 2001)
    4. IL-37 is a fundamental inhibitor of innate immunity. (PubMed id 20935647)1, 2 Nold M.F....Dinarello C.A. (Nat. Immunol. 2010)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity. (PubMed id 12496389)1, 3 Gao W....Gambotto A. (J. Immunol. 2003)
    8. Genomic organization of the interleukin-1 locus. (PubMed id 11991723)1, 2 Taylor S.L.... Sims J.E. (Genomics 2002)
    9. Identification and initial characterization of four novel members of the interleukin-1 family. (PubMed id 10744718)1, 2 Kumar S....Young P.R. (J. Biol. Chem. 2000)
    10. IL1HY1: a novel interleukin-1 receptor antagonist gene. (PubMed id 10512743)1, 3 Mulero J.J.... Ford J.E. (Biochem. Biophys. Res. Commun. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27178 HGNC: 15563 AceView: IL1F7 Ensembl:ENSG00000125571 euGenes: HUgn27178
    ECgene: IL37 H-InvDB: IL37

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL37 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
    SeattleSNPshttp://pga.gs.washington.edu/data/il1f7/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL37 gene:
    Search GeneIP for patents involving IL37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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