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IL36RN Gene

protein-coding   GIFtS: 50
GCID: GC02P113817

Interleukin 36 Receptor Antagonist

(Previous names: interleukin 1 family, member 5 (delta))
(Previous symbol: IL1F5)
  See IL36RN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 36 Receptor Antagonist1 2     FIL1(DELTA)2
IL1F51 2 3 5     IL36RA2
Interleukin-1 HY11 2 3     IL-1F5 (IL-1HY1, FIL1-Delta, IL-1RP3, IL-1L1, IL-1-Delta)2
Interleukin-1 Receptor Antagonist Homolog 11 2 3     IL1F5 (Canonical Product IL-1F5a)2
FIL1D2 3 5     Interleukin-36 Receptor Antagonist Protein2
IL1HY12 3 5     IL-1F53
IL1RP32 3 5     IL-1HY13
Interleukin 1 Family, Member 5 (Delta)1 2     IL-1L13
IL-1 Related Protein 31 2     IL-1RP33
Interleukin-1-Like Protein 12 3     FIL1 Delta3
IL1L12 3     IL-1 Delta3
IL-1ra Homolog 12 3     IL-1-Related Protein 33
PSORP2 5     Interleukin-1 Delta3
Family Of Interleukin 1-Delta1     Interleukin-1 Family Member 53
FIL12     

External Ids:    HGNC: 155611   Entrez Gene: 265252   Ensembl: ENSG000001366957   OMIM: 6055075   UniProtKB: Q9UBH03   

Export aliases for IL36RN gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL36RN Gene:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to
specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and
eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced
transcript variants encoding the same protein have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL36RN Gene:
IL36RN (interleukin 36 receptor antagonist) is a protein-coding gene. Diseases associated with IL36RN include ditra, and acute generalized exanthematous pustulosis. GO annotations related to this gene include cytokine activity and interleukin-1 receptor antagonist activity. An important paralog of this gene is IL36A.

UniProtKB/Swiss-Prot: I36RA_HUMAN, Q9UBH0
Function: Is a highly and a specific antagonist of the IL-1 receptor-related protein 2/IL1RL2-mediated response to
interleukin IL36G. Could constitute part of an independent signaling system analogous to interleukin-1 alpha
(IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial
barriers and takes part in local inflammatory response

Gene Wiki entry for IL36RN (IL1F5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IL36RN
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL36RN promoter sequence
   Search Chromatin IP Primers for IL36RN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL36RN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q14

IL36RN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL36RN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P113817:  view genomic region     (about GC identifiers)

Start:
113,816,215 bp from pter      End:
113,822,959 bp from pter
Size:
6,745 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: I36RA_HUMAN, Q9UBH0 (See protein sequence)
Recommended Name: Interleukin-36 receptor antagonist protein  
Size: 155 amino acids; 16962 Da
Secondary accessions: A8K2I4 Q56AT9 Q7RTZ6

Explore the universe of human proteins at neXtProt for IL36RN: NX_Q9UBH0

Explore proteomics data for IL36RN at MOPED


See IL36RN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_036407.1  NP_775262.1  

ENSEMBL proteins: 
 ENSP00000259212   ENSP00000376896   ENSP00000409262   ENSP00000475308  

IL36RN Human Recombinant Protein Products:

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Sino Biological Recombinant Protein for IL36RN
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Search eBioscience for Proteins for IL36RN 

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
IL: Interleukins and interleukin receptors

5 InterPro protein domains:
 IPR003297 IL-1RA/IL-36
 IPR000975 IL-1
 IPR020877 IL-1_CS
 IPR008996 Cytokine_IL1-like
 IPR027171 IL-36RA

Graphical View of Domain Structure for InterPro Entry Q9UBH0

ProtoNet protein and cluster: Q9UBH0

2 Blocks protein domains:
IPB000975 Interleukin-1 precursor family signature
IPB003297 Interleukin-1 receptor antagonist precursor IL-1RA signature


UniProtKB/Swiss-Prot: I36RA_HUMAN, Q9UBH0
Similarity: Belongs to the IL-1 family


Find genes that share domains with IL36RN           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: I36RA_HUMAN, Q9UBH0
Function: Is a highly and a specific antagonist of the IL-1 receptor-related protein 2/IL1RL2-mediated response to
interleukin IL36G. Could constitute part of an independent signaling system analogous to interleukin-1 alpha
(IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial
barriers and takes part in local inflammatory response
Induction: By phorbol ester (PMA) and bacterial lipopolysaccharides (LPS) treatment in macrophage cell line

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0005149interleukin-1 receptor binding IEA--
GO:0005152interleukin-1 receptor antagonist activity IEA--
     
Find genes that share ontologies with IL36RN           About GenesLikeMe


Phenotypes:
     8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Il1f5):
 cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
 integument  mortality/aging  normal 

Find genes that share phenotypes with IL36RN           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Il1f5tm1Kopf for IL36RN

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL36RN
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL36RN

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL36RN
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL36RN

miRNA
Products:
    
miRTarBase miRNAs that target IL36RN:
hsa-mir-16-5p (MIRT051062), hsa-mir-26b-5p (MIRT029800), hsa-mir-335-5p (MIRT018357)

Block miRNA regulation of human, mouse, rat IL36RN using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate IL36RN (see all 15):
hsa-miR-4303 hsa-miR-15a hsa-miR-1260b hsa-miR-497 hsa-miR-1260 hsa-miR-3692 hsa-miR-511 hsa-miR-424
SwitchGear 3'UTR luciferase reporter plasmidIL36RN 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for IL36RN
Predesigned siRNA for gene silencing in human, mouse, rat IL36RN

Gene Editing
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DNA2.0 Custom Protein Engineering Service for IL36RN

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Sino Biological Human cDNA Clone for IL36RN
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL36RN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL36RN
Addgene plasmids for IL36RN 

Cell Line
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Browse ESI BIO Cell Lines and PureStem Progenitors for IL36RN 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL36RN


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
I36RA_HUMAN, Q9UBH0: Secreted

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--

Find genes that share ontologies with IL36RN           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IL36RN About    
See pathways by source

SuperPathContained pathways About
1NOD-like Receptor Signaling Pathways
IL-1 Family Signaling Pathways0.44

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for IL36RN
    IL-1 Family Signaling Pathways




    Pathway & Disease-focused RT2 Profiler PCR Array including IL36RN: 
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for IL36RN

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

Selected Interacting proteins for IL36RN (Q9UBH02, 3 ENSP000002592124) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
SKILP127572, 3MINT-61634 I2D: score=3 
ZNF512BQ96KM62, 3MINT-60814 I2D: score=2 
SSBP2P818772, 3, ENSP000003229774MINT-67709 I2D: score=5 STRING: ENSP00000322977
MCM6Q145662, 3, ENSP000002641564MINT-66564 I2D: score=5 STRING: ENSP00000264156
SSBP4Q9BWG43, ENSP000002700614I2D: score=3 STRING: ENSP00000270061
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001960negative regulation of cytokine-mediated signaling pathway TAS10512743
GO:0032715negative regulation of interleukin-6 production IEA--

Find genes that share ontologies with IL36RN           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IL36RN (I36RA)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for IL36RN gene (2 alternative transcripts): 
NM_012275.2  NM_173170.1  

Unigene Cluster for IL36RN:

Interleukin 36 receptor antagonist
Hs.516301  [show with all ESTs]
Unigene Representative Sequence: AF186094
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000346807(uc002tis.3) ENST00000393200(uc002tit.3) ENST00000437409
ENST00000514072
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat IL36RN using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate IL36RN (see all 15):
hsa-miR-4303 hsa-miR-15a hsa-miR-1260b hsa-miR-497 hsa-miR-1260 hsa-miR-3692 hsa-miR-511 hsa-miR-424
SwitchGear 3'UTR luciferase reporter plasmidIL36RN 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for IL36RN
Predesigned siRNA for gene silencing in human, mouse, rat IL36RN
Clone
Products:
     
OriGene clones in human, mouse for IL36RN (see all 14)
OriGene ORF clones in mouse, rat for IL36RN
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for IL36RN
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL36RN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL36RN
Addgene plasmids for IL36RN 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for IL36RN
OriGene qSTAR qPCR primer pairs in human, mouse for IL36RN
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL36RN
  QuantiTect SYBR Green Assays in human, mouse, rat IL36RN
  QuantiFast Probe-based Assays in human, mouse, rat IL36RN

Additional mRNA sequence: 

AF186094.1 AF201830.1 AF230377.1 AJ242737.1 AJ242738.1 AK002125.1 AK290249.1 AY359117.1 
BC000945.2 BC024747.1 

3 DOTS entries:

DT.40316781  DT.97775169  DT.100709380 

Selected AceView cDNA sequences (see all 39):

AF230377 NM_012275 AI469873 CA310393 CR613851 BI089828 BF509095 BX477358 
NM_173170 BX091500 AL545100 BC000945 AL570964 BF435174 AJ242738 CD368042 
AW014217 BI090567 AA722902 AK002125 AF186094 AY359117 BC024747 R70041 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IL36RN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IL36RN Expression
About this image

IL36RN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IL36RN Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.516301

UniProtKB/Swiss-Prot: I36RA_HUMAN, Q9UBH0
Tissue specificity: Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or
melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional
psoriasis skin

    Pathway & Disease-focused RT2 Profiler PCR Array including IL36RN: 
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for IL36RN
OriGene qSTAR qPCR primer pairs in human, mouse for IL36RN
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL36RN
QuantiTect SYBR Green Assays in human, mouse, rat IL36RN
QuantiFast Probe-based Assays in human, mouse, rat IL36RN
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL36RN

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for IL36RN gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il1f51 , 5 interleukin 1 family, member 5 (delta)1, 5 84.3(n)1
90.97(a)1
  2 (16.31 cM)5
544501  NM_019451.21  NP_062324.21 
 242769545 


ENSEMBL Gene Tree for IL36RN (if available)
TreeFam Gene Tree for IL36RN (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IL36RN gene
IL36A2  IL36B2  IL372  IL1RN2  IL1F102  IL36G2  
4 SIMAP similar genes for IL36RN using alignment to 3 protein entries:     I36RA_HUMAN (see all proteins):
IL1F10    IL1RN    IL36A    IL36G

Find genes that share paralogs with IL36RN           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IL36RN (see all 265)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1444785191,2,,4
C,FPsoriasis generalized pustular (PSORP)4 --113333702(+) CGAGTC/TGGCTG 4 S L mis12Minor allele frequency- T:0.00NA EU 5873
VAR_0689724
Psoriasis generalized pustular (PSORP)4--see VAR_0689722 T R mis40--------
VAR_0666464
Psoriasis generalized pustular (PSORP)4--see VAR_0666462 L P mis40--------
VAR_0666474
Psoriasis generalized pustular (PSORP)4--see VAR_0666472 R W mis40--------
rs1998241361,2
Cuntested1113333697(+) AGCTTC/TGAGTC 4 F syn11Minor allele frequency- T:0.00EU 1323
rs1893837051,2
--113327817(+) AGGCAA/GGAGAG 1 -- us2k10--------
rs96774691,2
C,F--113327929(+) acctcC/Tcactg 1 -- us2k12Minor allele frequency- T:0.03CSA WA 119
rs1813525511,2
--113327981(+) CAAGAA/TGAAAT 1 -- us2k10--------
rs1858187111,2
--113328010(+) AAACCA/GTATCA 1 -- us2k10--------
rs1506475341,2
--113328113(+) GCCAAA/CGTTTA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for IL36RN (113816215 - 113822959 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for IL36RN:    About this table    
Variant IDTypeSubtypePubMed ID
nsv2881CNV Loss18451855

Human Gene Mutation Database (HGMD): IL36RN
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing IL36RN
DNA2.0 Custom Variant and Variant Library Synthesis for IL36RN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605507   
OMIM disorders: 614204  
UniProtKB/Swiss-Prot: I36RA_HUMAN, Q9UBH0
  • Psoriasis generalized pustular (PSORP) [MIM:614204]: A life-threatening disease defined by repeated
    flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with
    pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 7 diseases for IL36RN:    
    About MalaCards
    ditra    acute generalized exanthematous pustulosis    generalized pustular psoriasis    pustulosis palmaris et plantaris
    acrodermatitis continua suppurativa of hallopeau    acrodermatitis    alopecia areata


    Find genes that share disorders with IL36RN           About GenesLikeMe


    Export disorders for IL36RN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL36RN gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with IL36RN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IL1HY1: a novel interleukin-1 receptor antagonist gene. (PubMed id 10512743)1, 2, 3, 9 Mulero J.J.... Ford J.E. (Biochem. Biophys. Res. Commun. 1999)
    2. Four new members expand the IL-1 superfamily. (PubMed id 10625660)1, 2, 3, 9 Smith D.E....Sims J.E. (J. Biol. Chem. 2000)
    3. A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities. (PubMed id 11093146)1, 2, 9 Barton J.L.... Nicklin M.J.H. (Eur. J. Immunol. 2000)
    4. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. (PubMed id 11466363)1, 2, 9 Debets R....Kastelein R.A. (J. Immunol. 2001)
    5. Mutation analysis of the IL36RN gene in 14 Japanese patients with generalized pustular psoriasis. (PubMed id 22903787)1, 2 Farooq M.... Shimomura Y. (Hum. Mutat. 2013)
    6. Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis. (PubMed id 21839423)1, 2 Onoufriadis A.... Barker J.N. (Am. J. Hum. Genet. 2011)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26525 HGNC: 15561 AceView: IL1F5 Ensembl:ENSG00000136695 euGenes: HUgn26525
    ECgene: IL36RN H-InvDB: IL36RN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL36RN Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
    SeattleSNPshttp://pga.gs.washington.edu/data/il1f5/

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL36RN gene:
    Search GeneIP for patents involving IL36RN

    GeneCards and IP:
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