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Aliases for IL36G Gene

Aliases for IL36G Gene

  • Interleukin 36, Gamma 2 3 5
  • Interleukin-1 Homolog 1 2 3 4
  • Interleukin-1 Epsilon 2 3 4
  • Interleukin 1-Related Protein 2 2 3
  • Interleukin 1 Family, Member 9 2 3
  • Interleukin-1 Family Member 9 3 4
  • IL-1-Related Protein 2 3 4
  • IL-1 Epsilon 3 4
  • IL-1RP2 3 4
  • IL-1F9 3 4
  • IL-1H1 3 4
  • IL1RP2 3 4
  • IL1F9 3 4
  • IL1H1 3 4
  • IL1E 3 4
  • IL-1 Related Protein 2 3
  • IL-1(EPSILON) 3
  • IL-1-Epsilon 3

External Ids for IL36G Gene

Previous HGNC Symbols for IL36G Gene

  • IL1F9

Previous GeneCards Identifiers for IL36G Gene

  • GC02P113731

Summaries for IL36G Gene

Entrez Gene Summary for IL36G Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for IL36G Gene

IL36G (Interleukin 36, Gamma) is a Protein Coding gene. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include cytokine activity and interleukin-1 receptor binding. An important paralog of this gene is IL1RN.

UniProtKB/Swiss-Prot for IL36G Gene

  • Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.

Gene Wiki entry for IL36G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL36G Gene

Genomics for IL36G Gene

Genomic Location for IL36G Gene

Chromosome:
2
Start:
112,972,329 bp from pter
End:
112,985,672 bp from pter
Size:
13,344 bases
Orientation:
Plus strand

Genomic View for IL36G Gene

Genes around IL36G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL36G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL36G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL36G Gene

No data available for Regulatory Elements for IL36G Gene

Proteins for IL36G Gene

  • Protein details for IL36G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZH8-IL36G_HUMAN
    Recommended name:
    Interleukin-36 gamma
    Protein Accession:
    Q9NZH8
    Secondary Accessions:
    • Q56B91
    • Q6UVX7
    • Q7RTZ9

    Protein attributes for IL36G Gene

    Size:
    169 amino acids
    Molecular mass:
    18721 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL36G Gene

    Alternative splice isoforms for IL36G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL36G Gene

Proteomics data for IL36G Gene at MOPED

Post-translational modifications for IL36G Gene

  • N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL36G Gene

Antibody Products

  • R&D Systems Antibodies for IL36G (IL-36 gamma/IL-1F9)

No data available for DME Specific Peptides for IL36G Gene

Domains & Families for IL36G Gene

Gene Families for IL36G Gene

Protein Domains for IL36G Gene

Suggested Antigen Peptide Sequences for IL36G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZH8

UniProtKB/Swiss-Prot:

IL36G_HUMAN :
  • Belongs to the IL-1 family.
Family:
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL36G: view

Function for IL36G Gene

Molecular function for IL36G Gene

UniProtKB/Swiss-Prot Function:
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.
UniProtKB/Swiss-Prot Induction:
By TNF and by IFNG/IFN-gamma in keratinocytes. By Aspergillus fumigatus conidia in peripheral blood mnonocytes; involves CLEC7A and SYK.
genes like me logo Genes that share phenotypes with IL36G: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IL36G

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IL36G Gene

Localization for IL36G Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL36G Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL36G Gene COMPARTMENTS Subcellular localization image for IL36G gene
Compartment Confidence
extracellular 4
cytosol 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for IL36G Gene

Pathways & Interactions for IL36G Gene

genes like me logo Genes that share pathways with IL36G: view

Pathways by source for IL36G Gene

1 R&D Systems pathway for IL36G Gene

Interacting Proteins for IL36G Gene

Gene Ontology (GO) - Biological Process for IL36G Gene

None

No data available for SIGNOR curated interactions for IL36G Gene

Drugs & Compounds for IL36G Gene

No Compound Related Data Available

Transcripts for IL36G Gene

mRNA/cDNA for IL36G Gene

Unigene Clusters for IL36G Gene

Interleukin 36, gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL36G Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for IL36G Gene

GeneLoc Exon Structure for
IL36G
ECgene alternative splicing isoforms for
IL36G

Expression for IL36G Gene

mRNA expression in normal human tissues for IL36G Gene

mRNA differential expression in normal tissues according to GTEx for IL36G Gene

This gene is overexpressed in Minor Salivary Gland (x22.5), Skin - Sun Exposed (Lower leg) (x14.1), Esophagus - Mucosa (x8.1), and Skin - Not Sun Exposed (Suprapubic) (x6.8).

Protein differential expression in normal tissues from HIPED for IL36G Gene

This gene is overexpressed in Oral epithelium (36.3) and Saliva (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL36G Gene



SOURCE GeneReport for Unigene cluster for IL36G Gene Hs.211238

mRNA Expression by UniProt/SwissProt for IL36G Gene

Q9NZH8-IL36G_HUMAN
Tissue specificity: Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. Expressed in bronchial epithelial. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up-regulated in lesional psoriasis skin. Expressed in monocyte-derived dendritic cells and M1 macrophages.
genes like me logo Genes that share expression patterns with IL36G: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for IL36G Gene

Orthologs for IL36G Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL36G Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL36G 35
  • 74.36 (n)
  • 67.95 (a)
IL36G 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL36G 35
  • 73.01 (n)
  • 64.42 (a)
IL36G 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il1f9 35
  • 71.46 (n)
  • 60.27 (a)
Il1f9 16
Il1f9 36
  • 46 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL1F9 35
  • 98.82 (n)
  • 98.82 (a)
IL36G 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il36g 35
  • 71.92 (n)
  • 61.64 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
Species with no ortholog for IL36G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL36G Gene

ENSEMBL:
Gene Tree for IL36G (if available)
TreeFam:
Gene Tree for IL36G (if available)

Paralogs for IL36G Gene

Paralogs for IL36G Gene

(4) SIMAP similar genes for IL36G Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IL36G: view

Variants for IL36G Gene

Sequence variations from dbSNP and Humsavar for IL36G Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6707930 - 112,980,053(+) TTGAG(A/C)AAGGC reference, missense
rs1446517 -- 112,972,608(-) TCTCA(C/T)AGGTG intron-variant
rs2121334 -- 112,979,962(-) AGTCA(C/G)AAAGA intron-variant
rs2121335 -- 112,978,485(-) AAGTT(C/T)TGAGC intron-variant
rs3075080 -- 112,979,862(+) TGAAT(-/GAATGAAT)ATGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL36G Gene

Variant ID Type Subtype PubMed ID
nsv2880 CNV Loss 18451855
nsv874878 CNV Gain 21882294

Variation tolerance for IL36G Gene

Residual Variation Intolerance Score: 69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 35.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL36G Gene

HapMap Linkage Disequilibrium report
IL36G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL36G Gene

Disorders for IL36G Gene

Relevant External Links for IL36G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL36G

No disorders were found for IL36G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL36G Gene

Publications for IL36G Gene

  1. Identification and initial characterization of four novel members of the interleukin-1 family. (PMID: 10744718) Kumar S. … Young P.R. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. (PMID: 14734551) Towne J.E. … Sims J.E. (J. Biol. Chem. 2004) 3 23
  3. A sequence-based map of the nine genes of the human interleukin-1 cluster. (PMID: 11991722) Nicklin M.J.H. … Kornman K. (Genomics 2002) 2 3
  4. Genomic organization of the interleukin-1 locus. (PMID: 11991723) Taylor S.L. … Sims J.E. (Genomics 2002) 2 3
  5. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. (PMID: 11466363) Debets R. … Kastelein R.A. (J. Immunol. 2001) 3 23

Products for IL36G Gene

Sources for IL36G Gene

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