IL36G Gene
protein-coding GIFtS: 47
GCID: GC02P113731
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interleukin 36, gamma(Previous names: interleukin 1 family, member 9 )
(Previous symbol: IL1F9)
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Aliases
for IL36G gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interleukin 36, Gamma1 2 | | Interleukin-1 Family Member 92 3 | | IL1F91 2 3 5 | | Interleukin-1 Homolog 12 3 | | IL1H11 2 3 5 | | IL-1 Epsilon2 3 | | IL-1F91 2 3 | | IL-1-Related Protein 22 3 | | IL-1H11 2 3 | | IL-1(EPSILON)2 | | IL-1RP21 2 3 | | IL-1-Epsilon1 | | IL1E1 2 3 | | IL-1 Related Protein 22 | | IL1RP22 3 5 | | Interleukin 1-Related Protein 22 | | Interleukin 1 Family, Member 91 2 | | Interleukin-36 Gamma2 | | Interleukin-1 Epsilon2 3 | | |
Export aliases for IL36G gene to outside databases |
Summaries
for IL36G gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IL36G:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine ismediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family,member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reportedto stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes canalso be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight otherinterleukin 1 family genes form a cytokine gene cluster on chromosome 2. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: IL36G_HUMAN, Q9NZH8Function: Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Couldconstitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptoragonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in localinflammatory response
Gene Wiki entry for IL36G (IL1F9)
|
Genomic Views
for IL36G gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for IL36G
Other transcription factors
Search SABiosciences Chromatin IP Primers for IL36G
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL36G |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q12-q21 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q12-q21IL36G Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P113731: view genomic region
(about GC identifiers)
Start:
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113,730,780 bp from pter |
End:
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113,743,227 bp from pter |
Size:
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12,448 bases |
Orientation:
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plus strand |
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Proteins
for IL36G gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IL36G_HUMAN, Q9NZH8 (See
protein sequence)Recommended Name: Interleukin-36 gamma Size: 169 amino acids; 18721 Da
Subcellular location: Secreted
Secondary accessions: Q56B91 Q6UVX7 Q7RTZ9Alternative splicing: 2 isoforms: Q9NZH8-1 Q9NZH8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for IL36G: NX_Q9NZH8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NZH8
IL36G Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_062564.1
ENSEMBL proteins: ENSP00000411639 ENSP00000365672 ENSP00000259205
Human Recombinant Protein Products for IL36G:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005615 | extracellular space |
IEA | -- |
IL36G for ontologies About GeneDecksing
IL36G Antibody Products:
Assay Products for IL36G: |
Protein
Domains /
Families
for IL36G gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IL36G for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NZH8ProtoNet protein and cluster: Q9NZH8 1 Blocks protein family: IPB000975 Interleukin-1 precursor family signature
UniProtKB/Swiss-Prot: IL36G_HUMAN, Q9NZH8Similarity: Belongs to the IL-1 family |
Function
for IL36G gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: IL36G_HUMAN, Q9NZH8Function: Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Couldconstitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptoragonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in localinflammatory responseInduction: By TNF and by IFNG/IFN-gamma in keratinocytes Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005125 | cytokine activity |
IEA | -- | | GO:0005152 | interleukin-1 receptor antagonist activity |
IEA | -- |
IL36G for ontologies About GeneDecksing
Phenotypes:
1 MGI phenotypic allele  for Il1f9 (no phenotypes)
IL36G for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Il1f9tm1Lex for IL36G
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL36G (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL36G
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL36G |
|
Pathways & Interactions
for IL36G gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL36G
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
IL36G for ontologies About GeneDecksing
|
Drugs & Compounds
for IL36G gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IL36G
Search CenterWatch for drugs/clinical trials and news about IL36G
|
Transcripts
for IL36G gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IL36G gene: NM_019618.2 Unigene Cluster for IL36G: Interleukin 36, gamma Hs.211238 [show with all ESTs]Unigene Representative Sequence: AY3591113 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000447128 ENST00000376489 ENST00000259205(uc002tio.1 uc010fkr.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL36G (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL36G
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for IL36G | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL36G | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL36G |
Additional cDNA sequence: AF200492.1 AF206696.1 AY359111.1 BC096721.1 BC098130.1 BC098155.1 BC098337.1 3 DOTS entries: DT.70102645 DT.101977731 DT.92012549 17 AceView cDNA sequences: BX282030 AI828999 AF206696 CD364781 NM_019618 AW361172 AF200492 AW853610 CD369363 AI814314 AI819230 BE140462 AW937349 AW361245 AY359111 AW937348 BE183197
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for IL36G About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
|---|
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| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for IL36G
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Expression
for IL36G gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IL36G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTAGCACAG
About this image
See IL36G Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL36G
SOURCE GeneReport for Unigene cluster: Hs.211238
UniProtKB/Swiss-Prot: IL36G_HUMAN, Q9NZH8Tissue specificity: Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. In skinis expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up-regulated in lesionalpsoriasis skin
SABiosciences Expression via Pathway-Focused PCR Array including IL36G:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL36G
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL36G | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL36G | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL36G | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL36G |
Orthologs
for IL36G gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IL36G gene from 1/8 species (see all 8) About this table
ENSEMBL Gene Tree for IL36G (if available)
TreeFam Gene Tree for IL36G (if available) |
Paralogs
for IL36G gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IL36G gene
- IL36A2 IL372 IL1RN2 IL36RN2 IL1F102
5 SIMAP similar genes for IL36G using alignment to 2 protein entries: IL36G_HUMAN (see all proteins):IL36A IL36B IL36RN IL37 IL1F10
IL36G for paralogs About GeneDecksing
|
Genomic Variants
for IL36G gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IL36G (113730780 - 113743227 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL36G: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL36G |
|
Disorders
/ Diseases
for IL36G gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IL36G for disorders About GeneDecksing
OMIM gene information: 605542
OMIM disorders: --
8  diseases for IL36G: About MalaCardsherpes simplex ankylosing spondylitis spondylitis rheumatoid arthritis
hepatitis b arthritis psoriasis hepatitis
Export disorders for IL36G gene to outside databases
|
Publications
for IL36G gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IL36G gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with IL36G) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and initial characterization of four novel members of the interleukin-1 family. (PubMed id 10744718)1, 2, 3, 9 Kumar S....Young P.R. (2000)
- A sequence-based map of the nine genes of the human interleukin-1 cluster. (PubMed id 11991722)1, 2, 3 Nicklin M.J.H....Kornman K. (2002)
- Identification and gene organization of three novel members of the IL-1 family on human chromosome 2. (PubMed id 10860666)1, 2, 3 Busfield S.J.... Pan Y. (2000)
- Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. (PubMed id 11466363)1, 2, 9 Debets R....Kastelein R.A. (2001)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Genomic organization of the interleukin-1 locus. (PubMed id 11991723)1, 3 Taylor S.L....Sims J.E. (2002)
- Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. (PubMed id 14734551)1, 9 Towne J.E....Sims J.E. (2004)
- IL-36g/IL-1F9, an innate T-bet target in myeloid cells . (PubMed id 23095752)1 Bachmann M....Muhl H. (2012)
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External Searches for IL36G gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IL36G gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IL36G gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IL36G gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IL36G | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/Interleukin_1 | | SeattleSNPs | http://pga.gs.washington.edu/data/il1f9/ |
|
| | |
About This Section
| Patent Information for IL36G gene:
Search GeneIP for patents involving IL36G
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IL36G gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for IL36G | | OriGene shRNA RFP for IL36G | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL36G | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL36G | | | OriGene Protein Over-expression Lysate for IL36G | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IL36G | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL36G | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL36G | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IL36G | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL36G |
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