Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL36G Gene

protein-coding   GIFtS: 48
GCID: GC02P113731

Interleukin 36, Gamma

(Previous names: interleukin 1 family, member 9)
(Previous symbol: IL1F9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 36, Gamma1 2     IL-1H12 3
IL1F91 2 3 5     IL-1RP22 3
Interleukin-1 Epsilon1 2 3     IL1E2 3
Interleukin-1 Homolog 11 2 3     IL-1 Epsilon2 3
IL1H12 3 5     IL-1-Related Protein 22 3
IL1RP22 3 5     IL-1(EPSILON)2
Interleukin 1 Family, Member 91 2     IL-1-epsilon2
Interleukin 1-Related Protein 21 2     IL-1 Related Protein 22
Interleukin-1 Family Member 92 3     Interleukin-36 Gamma2
IL-1F92 3     

External Ids:    HGNC: 157411   Entrez Gene: 563002   Ensembl: ENSG000001366887   OMIM: 6055425   UniProtKB: Q9NZH83   

Export aliases for IL36G gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL36G Gene:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine
is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1
family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B)
are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in
keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This
gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively
spliced transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jun
2013)

GeneCards Summary for IL36G Gene: 
IL36G (interleukin 36, gamma) is a protein-coding gene. Diseases associated with IL36G include herpes simplex, and ankylosing spondylitis. GO annotations related to this gene include cytokine activity and interleukin-1 receptor antagonist activity. An important paralog of this gene is IL36A.

UniProtKB/Swiss-Prot: IL36G_HUMAN, Q9NZH8
Function: Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein
2/IL1RL2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta
(IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and
takes part in local inflammatory response

Gene Wiki entry for IL36G (IL1F9) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022135.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IL36G
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL36G promoter sequence
   Search SABiosciences Chromatin IP Primers for IL36G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL36G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12-q21   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q12-q21

IL36G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL36G gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P113731:  view genomic region     (about GC identifiers)

Start:
113,730,780 bp from pter      End:
113,743,242 bp from pter
Size:
12,463 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL36G_HUMAN, Q9NZH8 (See protein sequence)
Recommended Name: Interleukin-36 gamma  
Size: 169 amino acids; 18721 Da
Subcellular location: Secreted
Secondary accessions: Q56B91 Q6UVX7 Q7RTZ9
Alternative splicing: 2 isoforms:  Q9NZH8-1   Q9NZH8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL36G: NX_Q9NZH8

Explore proteomics data for IL36G at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZH8

  • IL36G Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL36G Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001265497.1  NP_062564.1  

    ENSEMBL proteins: 
     ENSP00000411639   ENSP00000365672   ENSP00000259205  

    Human Recombinant Protein Products for IL36G: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL36G (IL-36 gamma/IL-1F9)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IL36G
    OriGene Protein Over-expression Lysate for IL36G
    OriGene MassSpec for IL36G 
    OriGene Custom Protein Services for IL36G
    GenScript Custom Purified and Recombinant Proteins Services for IL36G
    Novus Biologicals IL36G Proteins
    Novus Biologicals IL36G Lysate
    Sino Biological Recombinant Protein for IL36G
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for IL36G
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    IL36G for ontologies           About GeneDecksing



    IL36G Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IL36G (IL-36 gamma/IL-1F9)
    OriGene Antibodies for IL36G
    OriGene Custom Antibody Services for IL36G
    GenScript Custom Superior Antibodies Services for IL36G
    Novus Biologicals IL36G Antibodies
    Abcam antibodies for IL36G
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for IL36G
    LSBio Antibodies in human, mouse, rat for IL36G 

    Assay Products for IL36G: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL36G
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IL36G
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    4 InterPro protein domains:
     IPR003297 IL-1RA/IL-36
     IPR000975 Interleukin_1
     IPR027162 Interleukin-36_gamma
     IPR008996 Cytokine_IL1-like

    Graphical View of Domain Structure for InterPro Entry Q9NZH8

    ProtoNet protein and cluster: Q9NZH8

    1 Blocks protein domain: IPB000975 Interleukin-1 precursor family signature

    UniProtKB/Swiss-Prot: IL36G_HUMAN, Q9NZH8
    Similarity: Belongs to the IL-1 family


    IL36G for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL36G_HUMAN, Q9NZH8
    Function: Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein
    2/IL1RL2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta
    (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and
    takes part in local inflammatory response
    Induction: By TNF and by IFNG/IFN-gamma in keratinocytes

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005149interleukin-1 receptor binding IEA--
         
    IL36G for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Il1f9 (no phenotypes)

    IL36G for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il1f9tm1Lex for IL36G

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL36G 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL36G

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL36G 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL36G 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL36G
    1 QIAGEN miScript miRNA Assays for microRNA that regulate IL36G:
    hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidIL36G 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL36G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL36G

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL36G
    Sirion Biotech Customized adenovirus for overexpression of IL36G

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IL36G (see all 6)
    OriGene ORF clones in mouse, rat for IL36G
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IL36G
    Sino Biological Human cDNA Clone for IL36G
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL36G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL36G
    Sirion Biotech Customized lentivirus for stable overexpression of IL36G 
                         Customized lentivirus expression plasmids for stable overexpression of IL36G 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL36G
    Search LifeMap BioReagents cell lines for IL36G
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL36G


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL36G

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001819positive regulation of cytokine production ----
    GO:0006954inflammatory response IEA--
    GO:0007267cell-cell signaling TAS10744718
    GO:0032755positive regulation of interleukin-6 production IEA--

    IL36G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL36G

    Search CenterWatch for drugs/clinical trials and news about IL36G

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL36G gene (2 alternative transcripts): 
    NM_001278568.1  NM_019618.3  

    Unigene Cluster for IL36G:

    Interleukin 36, gamma
    Hs.211238  [show with all ESTs]
    Unigene Representative Sequence: AY359111
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447128 ENST00000376489 ENST00000259205(uc002tio.1 uc010fkr.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL36G
    1 QIAGEN miScript miRNA Assays for microRNA that regulate IL36G:
    hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidIL36G 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL36G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL36G
    Clone
    Products:
         
    OriGene clones in human, mouse for IL36G (see all 6)
    OriGene ORF clones in mouse, rat for IL36G
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IL36G
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL36G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL36G
    Sirion Biotech Customized lentivirus for stable overexpression of IL36G 
                         Customized lentivirus expression plasmids for stable overexpression of IL36G 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IL36G
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL36G
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL36G
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL36G

    Additional mRNA sequence: 

    AF200492.1 AF206696.1 AY359111.1 BC096721.1 BC098130.1 BC098155.1 BC098337.1 

    3 DOTS entries:

    DT.70102645  DT.101977731  DT.92012549 

    17 AceView cDNA sequences:

    AF206696 BX282030 NM_019618 AI828999 CD364781 AF200492 AW853610 CD369363 
    AW361172 AI814314 BE140462 AI819230 AW361245 AW937349 AY359111 AW937348 
    BE183197 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for IL36G    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:                    -                     


    ECgene alternative splicing isoforms for IL36G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL36G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTAGCACAG
    IL36G Expression
    About this image


    See IL36G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL36G

    SOURCE GeneReport for Unigene cluster: Hs.211238

    UniProtKB/Swiss-Prot: IL36G_HUMAN, Q9NZH8
    Tissue specificity: Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. In
    skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up-regulated in
    lesional psoriasis skin

        SABiosciences Expression via Pathway-Focused PCR Array including IL36G: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IL36G
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL36G
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL36G
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL36G
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL36G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL36G gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1f91 , 5 interleukin 1 family, member 91, 5 71.46(n)1
    60.27(a)1
      2 (16.24 cM)5
    2152571  NM_153511.31  NP_705731.21 
     241864765 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    31(a)
    30(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343238.1(908975-910584)
    GL343238.1(853473-859585)


    ENSEMBL Gene Tree for IL36G (if available)
    TreeFam Gene Tree for IL36G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL36G gene
    IL36A2  IL36B2  IL372  IL1RN2  IL36RN2  IL1F102  
    4 SIMAP similar genes for IL36G using alignment to 2 protein entries:     IL36G_HUMAN (see all proteins):
    IL36A    IL36B    IL36RN    IL37

    IL36G for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/194 SNPs in IL36G are shown (see all 194)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs170426761,2
    C,H--113733752(+) TGCTGG/CGAATT 1 -- us2k17Minor allele frequency- C:0.00NA NS EA 562
    rs755567471,2
    F--113733760(+) ATTCTA/CGGAAG 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1878596441,2
    --113733786(+) GTGCTC/TGGAAT 1 -- us2k10--------
    rs1420708971,2
    --113733793(+) GAATCC/TATTGA 1 -- us2k10--------
    rs1925867381,2
    --113733802(+) GAAGGA/GTCAGG 1 -- us2k10--------
    rs289472021,2
    C,F--113733825(+) GAGGGC/TGGAGG 1 -- us2k14Minor allele frequency- T:0.01NS NA WA 212
    rs1463289661,2
    --113733826(+) AGGGCA/GGAGGC 1 -- us2k10--------
    rs1843045081,2
    --113733877(+) CCTTCA/TTCTGG 1 -- us2k10--------
    rs1392893211,2
    --113733901(+) TAGCTA/GTACCC 1 -- us2k10--------
    rs1495684941,2
    --113734005(+) TGCTCC/TAAGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL36G (113730780 - 113743242 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL36G:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2880CNV Loss18451855
    nsv874878CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL36G
    DNA2.0 Custom Variant and Variant Library Synthesis for IL36G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605542    OMIM disorders: --

    9 diseases for IL36G:    About MalaCards
    herpes simplex    ankylosing spondylitis    spondylitis    psoriasis
    hepatitis b    rheumatoid arthritis    arthritis    hepatitis
    endotheliitis


    IL36G for disorders           About GeneDecksing


    Export disorders for IL36G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL36G gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with IL36G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and initial characterization of four novel members of the interleukin-1 family. (PubMed id 10744718)1, 2, 3, 9 Kumar S....Young P.R. (2000)
    2. A sequence-based map of the nine genes of the human interleukin-1 cluster. (PubMed id 11991722)1, 2, 3 Nicklin M.J.H....Kornman K. (2002)
    3. Identification and gene organization of three novel members of the IL-1 family on human chromosome 2. (PubMed id 10860666)1, 2, 3 Busfield S.J.... Pan Y. (2000)
    4. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. (PubMed id 11466363)1, 2, 9 Debets R....Kastelein R.A. (2001)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Genomic organization of the interleukin-1 locus. (PubMed id 11991723)1, 3 Taylor S.L....Sims J.E. (2002)
    9. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. (PubMed id 14734551)1, 9 Towne J.E....Sims J.E. (2004)
    10. IL-36g/IL-1F9, an innate T-bet target in myeloid cells . (PubMed id 23095752)1 Bachmann M....Muhl H. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56300 HGNC: 15741 AceView: IL1F9 Ensembl:ENSG00000136688 euGenes: HUgn56300
    ECgene: IL36G H-InvDB: IL36G

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL36G Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
    SeattleSNPshttp://pga.gs.washington.edu/data/il1f9/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL36G gene:
    Search GeneIP for patents involving IL36G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for IL36G (IL-36 gamma/IL-1F9)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for IL36G (IL-36 gamma/IL-1F9)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for IL36G   OriGene RNAi products in human, mouse, rat for IL36G  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for IL36G  
     OriGene MassSpec something-or-other for IL36G   OriGene clones in human, mouse for IL36G  
     OriGene qSTAR qPCR primer pairs in human, mouse for IL36G   OriGene Purified Protein for IL36G  
     OriGene ORF clones in mouse, rat for IL36G   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IL36G   OriGene Custom Protein Services for IL36G  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL36G
     QIAGEN SeqTarget long-range PCR primers for resequencing IL36G
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL36G
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL36G
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL36G
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL36G
     GenScript Custom Purified and Recombinant Proteins Services for IL36G GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for IL36G
     GenScript Custom Assay Services for IL36G GenScript Custom Superior Antibodies Services for IL36G
     GenScript Custom overexpressing Cell Line Services for IL36G CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for IL36G
     Search Chromatin IP Primers for IL36G
     RT2 qPCR Primer Assay in human, mouse, rat IL36G
     Search GNC Networks for IL36G
     SABiosciences PCR Arrays including human, mouse, rat IL36G
     Search Tocris compounds for IL36G
     Proteins and Antibodies for IL36G
     Browse Sino Biological Cell Lysates
     cDNA Clones for IL36G
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IL36G antibodies
     IL36G proteins
     IL36G lysates
     Antibodies for IL36G
     See all of Abcam's Antibodies, Kits and Proteins for IL36G
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for IL36G




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for IL36G
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL36G
     SwitchGear 3'UTR luciferase reporter plasmids for IL36G
     SwitchGear Promoter luciferase reporter plasmids for IL36G
     ThermoFisher Antibodies for IL36G
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL36G
     inGenious Targeting Laboratory - Custom generated mouse model solutions for IL36G
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL36G
    Customized:
     lentivirus for stable overexpression of IL36G
     lentivirus expression plasmids for stable overexpression of IL36G
     adenovirus for overexpression of IL36G
     LSBio Antibodies in human, mouse, rat for IL36G
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IL36G gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4