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IL36G Gene

protein-coding   GIFtS: 48
GCID: GC02P113731

Interleukin 36, Gamma

(Previous names: interleukin 1 family, member 9)
(Previous symbol: IL1F9)
  See IL36G-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 36, Gamma1 2     IL-1H12 3
IL1F91 2 3 5     IL-1RP22 3
Interleukin-1 Epsilon1 2 3     IL1E2 3
Interleukin-1 Homolog 11 2 3     IL-1 Epsilon2 3
IL1H12 3 5     IL-1-Related Protein 22 3
IL1RP22 3 5     IL-1(EPSILON)2
Interleukin 1 Family, Member 91 2     IL-1-epsilon2
Interleukin 1-Related Protein 21 2     IL-1 Related Protein 22
Interleukin-1 Family Member 92 3     Interleukin-36 Gamma2
IL-1F92 3     

External Ids:    HGNC: 157411   Entrez Gene: 563002   Ensembl: ENSG000001366887   OMIM: 6055425   UniProtKB: Q9NZH83   

Export aliases for IL36G gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL36G Gene:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine
is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1
family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B)
are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in
keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This
gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively
spliced transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jun
2013)

GeneCards Summary for IL36G Gene:
IL36G (interleukin 36, gamma) is a protein-coding gene. Diseases associated with IL36G include herpes simplex. GO annotations related to this gene include interleukin-1 receptor binding and cytokine activity. An important paralog of this gene is IL36A.

UniProtKB/Swiss-Prot: IL36G_HUMAN, Q9NZH8
Function: Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein
2/IL1RL2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta
(IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and
takes part in local inflammatory response

Gene Wiki entry for IL36G (IL1F9) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IL36G
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL36G promoter sequence
   Search Chromatin IP Primers for IL36G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL36G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12-q21   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q12-q21

IL36G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL36G gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P113731:  view genomic region     (about GC identifiers)

Start:
113,730,780 bp from pter      End:
113,743,242 bp from pter
Size:
12,463 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL36G_HUMAN, Q9NZH8 (See protein sequence)
Recommended Name: Interleukin-36 gamma  
Size: 169 amino acids; 18721 Da
Secondary accessions: Q56B91 Q6UVX7 Q7RTZ9
Alternative splicing: 2 isoforms:  Q9NZH8-1   Q9NZH8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL36G: NX_Q9NZH8

Explore proteomics data for IL36G at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IL36G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265497.1  NP_062564.1  

    ENSEMBL proteins: 
     ENSP00000411639   ENSP00000365672   ENSP00000259205  

    IL36G Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    4 InterPro protein domains:
     IPR003297 IL-1RA/IL-36
     IPR000975 IL-1
     IPR027162 IL-36_gamma
     IPR008996 Cytokine_IL1-like

    Graphical View of Domain Structure for InterPro Entry Q9NZH8

    ProtoNet protein and cluster: Q9NZH8

    1 Blocks protein domain: IPB000975 Interleukin-1 precursor family signature

    UniProtKB/Swiss-Prot: IL36G_HUMAN, Q9NZH8
    Similarity: Belongs to the IL-1 family


    Find genes that share domains with IL36G           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL36G_HUMAN, Q9NZH8
    Function: Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein
    2/IL1RL2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta
    (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and
    takes part in local inflammatory response
    Induction: By TNF and by IFNG/IFN-gamma in keratinocytes

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005149interleukin-1 receptor binding IEA--
         
    Find genes that share ontologies with IL36G           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Il1f9 (no phenotypes)

    Find genes that share phenotypes with IL36G           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il1f9tm1Lex for IL36G

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL36G
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL36G
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL36G

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate IL36G:
    hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidIL36G 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL36G_HUMAN, Q9NZH8: Secreted

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IL36G           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL36G About    
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    IL-1 Family Signaling Pathways0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL36G
        IL-1 Family Signaling Pathways




        Pathway & Disease-focused RT2 Profiler PCR Array including IL36G: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IL36G

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001819positive regulation of cytokine production ----
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007267cell-cell signaling TAS10744718
    GO:0032755positive regulation of interleukin-6 production IEA--

    Find genes that share ontologies with IL36G           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL36G



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL36G gene (2 alternative transcripts): 
    NM_001278568.1  NM_019618.3  

    Unigene Cluster for IL36G:

    Interleukin 36, gamma
    Hs.211238  [show with all ESTs]
    Unigene Representative Sequence: AY359111
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447128 ENST00000376489 ENST00000259205(uc002tio.1 uc010fkr.1)

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate IL36G:
    hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidIL36G 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat IL36G

    Additional mRNA sequence: 

    AF200492.1 AF206696.1 AY359111.1 BC096721.1 BC098130.1 BC098155.1 BC098337.1 

    3 DOTS entries:

    DT.70102645  DT.101977731  DT.92012549 

    17 AceView cDNA sequences:

    AI828999 BX282030 NM_019618 AF206696 CD364781 AI814314 AW361172 AF200492 
    CD369363 AW853610 BE140462 AI819230 AW937349 AW361245 AY359111 AW937348 
    BE183197 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for IL36G    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:                    -                     


    ECgene alternative splicing isoforms for IL36G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL36G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTAGCACAG
    IL36G Expression
    About this image

    IL36G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL36G Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.211238

    UniProtKB/Swiss-Prot: IL36G_HUMAN, Q9NZH8
    Tissue specificity: Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. In
    skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up-regulated in
    lesional psoriasis skin

        Pathway & Disease-focused RT2 Profiler PCR Array including IL36G: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL36G gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1f91 , 5 interleukin 1 family, member 91, 5 71.46(n)1
    60.27(a)1
      2 (16.24 cM)5
    2152571  NM_153511.31  NP_705731.21 
     241864765 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    32(a)
    30(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343238.1(908975-910584)
    GL343238.1(853473-859585)


    ENSEMBL Gene Tree for IL36G (if available)
    TreeFam Gene Tree for IL36G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL36G gene
    IL36A2  IL36B2  IL372  IL1RN2  IL36RN2  IL1F102  
    4 SIMAP similar genes for IL36G using alignment to 2 protein entries:     IL36G_HUMAN (see all proteins):
    IL36A    IL36B    IL36RN    IL37

    Find genes that share paralogs with IL36G           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL36G (see all 194)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs170426761,2
    C,H--113733752(+) TGCTGG/CGAATT 1 -- us2k17Minor allele frequency- C:0.00NA NS EA 562
    rs755567471,2
    F--113733760(+) ATTCTA/CGGAAG 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1878596441,2
    --113733786(+) GTGCTC/TGGAAT 1 -- us2k10--------
    rs1420708971,2
    --113733793(+) GAATCC/TATTGA 1 -- us2k10--------
    rs1925867381,2
    --113733802(+) GAAGGA/GTCAGG 1 -- us2k10--------
    rs289472021,2
    C,F--113733825(+) GAGGGC/TGGAGG 1 -- us2k14Minor allele frequency- T:0.01NS NA WA 212
    rs1463289661,2
    --113733826(+) AGGGCA/GGAGGC 1 -- us2k10--------
    rs1843045081,2
    --113733877(+) CCTTCA/TTCTGG 1 -- us2k10--------
    rs1392893211,2
    --113733901(+) TAGCTA/GTACCC 1 -- us2k10--------
    rs1495684941,2
    --113734005(+) TGCTCC/TAAGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL36G (113730780 - 113743242 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL36G:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2880CNV Loss18451855
    nsv874878CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL36G
    DNA2.0 Custom Variant and Variant Library Synthesis for IL36G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605542    OMIM disorders: --

    1 disease for IL36G:    
    About MalaCards
    herpes simplex


    Find genes that share disorders with IL36G           About GenesLikeMe


    Export disorders for IL36G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL36G gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with IL36G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and initial characterization of four novel members of the interleukin-1 family. (PubMed id 10744718)1, 2, 3, 9 Kumar S....Young P.R. (J. Biol. Chem. 2000)
    2. A sequence-based map of the nine genes of the human interleukin-1 cluster. (PubMed id 11991722)1, 2, 3 Nicklin M.J.H....Kornman K. (Genomics 2002)
    3. Identification and gene organization of three novel members of the IL-1 family on human chromosome 2. (PubMed id 10860666)1, 2, 3 Busfield S.J.... Pan Y. (Genomics 2000)
    4. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. (PubMed id 11466363)1, 2, 9 Debets R....Kastelein R.A. (J. Immunol. 2001)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Genomic organization of the interleukin-1 locus. (PubMed id 11991723)1, 3 Taylor S.L.... Sims J.E. (Genomics 2002)
    9. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. (PubMed id 14734551)1, 9 Towne J.E....Sims J.E. (J. Biol. Chem. 2004)
    10. IL-36I^/IL-1F9, an innate T-bet target in myeloid cells. (PubMed id 23095752)1 Bachmann M....MA1hl H. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56300 HGNC: 15741 AceView: IL1F9 Ensembl:ENSG00000136688 euGenes: HUgn56300
    ECgene: IL36G H-InvDB: IL36G

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL36G Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
    SeattleSNPshttp://pga.gs.washington.edu/data/il1f9/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL36G gene:
    Search GeneIP for patents involving IL36G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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