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Aliases for IL36G Gene

Aliases for IL36G Gene

  • Interleukin 36, Gamma 2 3 5
  • Interleukin-1 Homolog 1 2 3 4
  • Interleukin-1 Epsilon 2 3 4
  • Interleukin 1-Related Protein 2 2 3
  • Interleukin-1 Family Member 9 3 4
  • IL-1RP2 3 4
  • IL-1F9 3 4
  • IL-1H1 3 4
  • IL1RP2 3 4
  • IL1F9 3 4
  • IL1H1 3 4
  • IL1E 3 4
  • Interleukin 1 Family, Member 9 2
  • IL-1 Related Protein 2 3
  • IL-1-Related Protein 2 4
  • Interleukin-36 Gamma 3
  • IL-1(EPSILON) 3
  • IL-1 Epsilon 4
  • IL-1-Epsilon 3

External Ids for IL36G Gene

Previous HGNC Symbols for IL36G Gene

  • IL1F9

Previous GeneCards Identifiers for IL36G Gene

  • GC02P113731
  • GC02P112973
  • GC02P113106

Summaries for IL36G Gene

Entrez Gene Summary for IL36G Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for IL36G Gene

IL36G (Interleukin 36, Gamma) is a Protein Coding gene. Among its related pathways are Toll-Like receptor Signaling Pathways and Cytokine Signaling in Immune system. GO annotations related to this gene include cytokine activity and interleukin-1 receptor binding. An important paralog of this gene is IL36A.

UniProtKB/Swiss-Prot for IL36G Gene

  • Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.

Gene Wiki entry for IL36G Gene

Additional gene information for IL36G Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL36G Gene

Genomics for IL36G Gene

Regulatory Elements for IL36G Gene

Enhancers for IL36G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H112936 1.2 FANTOM5 ENCODE 19.8 -35.9 -35861 0 TBP CTCF ATF1 GTF2E2 JUN BACH1 ZNF175 CEBPG ZNF644 FOSL1 IL1B IL1RN IL36G IL36B IL37 HMGN2P23 IL1A CDK8P2 IL36RN GC02P113410
GH02H112875 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -93.3 -93313 7 FOXA2 RAD21 BATF RARA TCF12 GATA2 EGR1 FOS ETV6 RUNX3 IL1B IL1RN IL1A IL36B IL37 IL36G CKAP2L IL36RN PIR40727 XIAPP3
GH02H112792 2 FANTOM5 Ensembl ENCODE dbSUPER 11 -177.6 -177562 4 HDGF PKNOX1 ARNT ZNF766 CBX5 JUNB REST ZNF592 MEF2D SMARCA4 IL1B IL1RN ANAPC1 IL1A CKAP2L CBWD2 RGPD8 IL36G ZC3H6 TMEM87B
GH02H112811 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -159.0 -159024 4 ELF3 ATF1 BMI1 BATF RAD21 RARA EGR1 FOS ETV6 ATF7 IL1B IL1RN IL1A IL37 IL36B IL36G CKAP2L IL36RN GC02M112788
GH02H112884 1.6 FANTOM5 ENCODE dbSUPER 12.6 -87.0 -86983 1 TBL1XR1 RB1 ARID4B THRB RAD21 RARA ZSCAN5C ZNF143 ZNF207 ATF7 IL1B IL1RN IL1A IL37 IL36G CKAP2L IL36B IL36RN PIR39579 PIR40727
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL36G on UCSC Golden Path with GeneCards custom track

Genomic Location for IL36G Gene

Chromosome:
2
Start:
112,972,329 bp from pter
End:
112,985,672 bp from pter
Size:
13,344 bases
Orientation:
Plus strand

Genomic View for IL36G Gene

Genes around IL36G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL36G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL36G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL36G Gene

Proteins for IL36G Gene

  • Protein details for IL36G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZH8-IL36G_HUMAN
    Recommended name:
    Interleukin-36 gamma
    Protein Accession:
    Q9NZH8
    Secondary Accessions:
    • Q56B91
    • Q6UVX7
    • Q7RTZ9

    Protein attributes for IL36G Gene

    Size:
    169 amino acids
    Molecular mass:
    18721 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL36G Gene

    Alternative splice isoforms for IL36G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL36G Gene

Post-translational modifications for IL36G Gene

  • N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL36G Gene

Antibody Products

  • R&D Systems Antibodies for IL36G (IL-36 gamma/IL-1F9)
  • Santa Cruz Biotechnology (SCBT) Antibodies for IL36G

Protein Products

Assay Products

No data available for DME Specific Peptides for IL36G Gene

Domains & Families for IL36G Gene

Gene Families for IL36G Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IL36G Gene

Suggested Antigen Peptide Sequences for IL36G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZH8

UniProtKB/Swiss-Prot:

IL36G_HUMAN :
  • Belongs to the IL-1 family.
Family:
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL36G: view

Function for IL36G Gene

Molecular function for IL36G Gene

UniProtKB/Swiss-Prot Function:
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.
UniProtKB/Swiss-Prot Induction:
By TNF and by IFNG/IFN-gamma in keratinocytes. By Aspergillus fumigatus conidia in peripheral blood mnonocytes; involves CLEC7A and SYK.

Phenotypes From GWAS Catalog for IL36G Gene

Gene Ontology (GO) - Molecular Function for IL36G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005149 interleukin-1 receptor binding IBA --
genes like me logo Genes that share ontologies with IL36G: view
genes like me logo Genes that share phenotypes with IL36G: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IL36G

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IL36G
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IL36G Gene

Localization for IL36G Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL36G Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL36G gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for IL36G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IL36G: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL36G Gene

Pathways & Interactions for IL36G Gene

genes like me logo Genes that share pathways with IL36G: view

Pathways by source for IL36G Gene

1 R&D Systems pathway for IL36G Gene

Interacting Proteins for IL36G Gene

Gene Ontology (GO) - Biological Process for IL36G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0007267 cell-cell signaling TAS 10744718
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with IL36G: view

No data available for SIGNOR curated interactions for IL36G Gene

Drugs & Compounds for IL36G Gene

No Compound Related Data Available

Transcripts for IL36G Gene

mRNA/cDNA for IL36G Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL36G Gene

Interleukin 36, gamma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IL36G
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IL36G Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for IL36G Gene

GeneLoc Exon Structure for
IL36G
ECgene alternative splicing isoforms for
IL36G

Expression for IL36G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL36G Gene

mRNA differential expression in normal tissues according to GTEx for IL36G Gene

This gene is overexpressed in Minor Salivary Gland (x22.5), Skin - Sun Exposed (Lower leg) (x14.1), Esophagus - Mucosa (x8.1), and Skin - Not Sun Exposed (Suprapubic) (x6.8).

Protein differential expression in normal tissues from HIPED for IL36G Gene

This gene is overexpressed in Oral epithelium (36.3) and Saliva (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL36G Gene



NURSA nuclear receptor signaling pathways regulating expression of IL36G Gene:

IL36G

SOURCE GeneReport for Unigene cluster for IL36G Gene:

Hs.211238

mRNA Expression by UniProt/SwissProt for IL36G Gene:

Q9NZH8-IL36G_HUMAN
Tissue specificity: Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. Expressed in bronchial epithelial. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up-regulated in lesional psoriasis skin. Expressed in monocyte-derived dendritic cells and M1 macrophages.

Evidence on tissue expression from TISSUES for IL36G Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with IL36G: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL36G Gene

Orthologs for IL36G Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL36G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL36G 34
  • 99 (a)
OneToOne
IL1F9 33
  • 98.82 (n)
cow
(Bos Taurus)
Mammalia IL36G 33 34
  • 74.36 (n)
dog
(Canis familiaris)
Mammalia IL36G 33 34
  • 73.01 (n)
rat
(Rattus norvegicus)
Mammalia Il36g 33
  • 71.92 (n)
mouse
(Mus musculus)
Mammalia Il1f9 33 16 34
  • 71.46 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 32 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
Species where no ortholog for IL36G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL36G Gene

ENSEMBL:
Gene Tree for IL36G (if available)
TreeFam:
Gene Tree for IL36G (if available)

Paralogs for IL36G Gene

Paralogs for IL36G Gene

(4) SIMAP similar genes for IL36G Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IL36G: view

Variants for IL36G Gene

Sequence variations from dbSNP and Humsavar for IL36G Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000261689 -- 112,976,410(+) CCCTC(C/T)CCTCC upstream-variant-2KB
rs1001042152 -- 112,984,070(+) GGCCA(C/T)CCAAA intron-variant
rs1001075833 -- 112,977,800(+) TTGTG(C/T)GGATT upstream-variant-2KB
rs1001094081 -- 112,984,411(+) GCAAT(C/T)AGTCA intron-variant
rs1001375568 -- 112,985,617(+) CTTTG(C/T)GTATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IL36G Gene

Variant ID Type Subtype PubMed ID
nsv2880 CNV deletion 18451855
nsv961489 CNV duplication 23825009

Variation tolerance for IL36G Gene

Residual Variation Intolerance Score: 69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 35.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL36G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL36G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL36G Gene

Disorders for IL36G Gene

Relevant External Links for IL36G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL36G

No disorders were found for IL36G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL36G Gene

Publications for IL36G Gene

  1. Identification and initial characterization of four novel members of the interleukin-1 family. (PMID: 10744718) Kumar S … Young PR (The Journal of biological chemistry 2000) 2 3 4 22 60
  2. A sequence-based map of the nine genes of the human interleukin-1 cluster. (PMID: 11991722) Nicklin MJ … Kornman K (Genomics 2002) 2 3 4 60
  3. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. (PMID: 11466363) Debets R … Kastelein RA (Journal of immunology (Baltimore, Md. : 1950) 2001) 3 4 22 60
  4. Identification and gene organization of three novel members of the IL-1 family on human chromosome 2. (PMID: 10860666) Busfield SJ … Pan Y (Genomics 2000) 2 3 4 60
  5. IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin. (PMID: 24829417) Foster AM … Johnston A (Journal of immunology (Baltimore, Md. : 1950) 2014) 3 4 60

Products for IL36G Gene

Sources for IL36G Gene

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