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Aliases for IL36B Gene

Aliases for IL36B Gene

  • Interleukin 36, Beta 2 3
  • IL1F8 3 4 6
  • IL1H2 3 4 6
  • Interleukin 1 Family, Member 8 (Eta) 2 3
  • Interleukin-1 Family Member 8 3 4
  • Interleukin-1 Homolog 2 3 4
  • Interleukin-1 Eta 3 4
  • FIL1 Eta 3 4
  • IL-1 Eta 3 4
  • IL-1F8 3 4
  • IL-1H2 3 4
  • FIL1H 3 6
  • IL1F8 (Canonical Product IL-1F8a) 3
  • Interleukin-1 Superfamily E 3
  • Family Of Interleukin 1-Eta 3
  • Interleukin-36 Beta 3
  • Interleukin 1, Eta 3
  • IL-1F8 (FIL1-Eta) 3
  • FIL1-(ETA) 3
  • FILI-(ETA) 3
  • IL1-ETA 3
  • FIL1 3

External Ids for IL36B Gene

Previous HGNC Symbols for IL36B Gene

  • IL1F8

Previous GeneCards Identifiers for IL36B Gene

  • GC02M113779

Summaries for IL36B Gene

Entrez Gene Summary for IL36B Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL36B Gene

IL36B (Interleukin 36, Beta) is a Protein Coding gene. Among its related pathways are NOD-like Receptor Signaling Pathways. GO annotations related to this gene include cytokine activity and interleukin-1 receptor binding. An important paralog of this gene is IL1RN.

UniProtKB/Swiss-Prot for IL36B Gene

  • Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.

Gene Wiki entry for IL36B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL36B Gene

Genomics for IL36B Gene

Genomic Location for IL36B Gene

Start:
113,022,091 bp from pter
End:
113,052,867 bp from pter
Size:
30,777 bases
Orientation:
Minus strand

Genomic View for IL36B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL36B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL36B Gene

No data available for Regulatory Elements for IL36B Gene

Proteins for IL36B Gene

  • Protein details for IL36B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZH7-IL36B_HUMAN
    Recommended name:
    Interleukin-36 beta
    Protein Accession:
    Q9NZH7
    Secondary Accessions:
    • Q3MIH0
    • Q53SR6
    • Q7RTZ7
    • Q9UHA5

    Protein attributes for IL36B Gene

    Size:
    164 amino acids
    Molecular mass:
    18522 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IL36B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL36B Gene

Proteomics data for IL36B Gene at MOPED

Post-translational modifications for IL36B Gene

  • N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL36B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL36B (IL-36 beta/IL-1F8)
  • Santa Cruz Biotechnology (SCBT) Antibodies for IL36B

No data available for DME Specific Peptides for IL36B Gene

Domains for IL36B Gene

Gene Families for IL36B Gene

HGNC:
  • IL :Interleukins and interleukin receptors

Protein Domains for IL36B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL36B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZH7

UniProtKB/Swiss-Prot:

IL36B_HUMAN :
  • Q9NZH7
Family:
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL36B: view

Function for IL36B Gene

Molecular function for IL36B Gene

UniProtKB/Swiss-Prot Function: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.
UniProtKB/Swiss-Prot Induction: By proinflammatory cytokines IL1A, IL1B and TNF in synovial fibroblasts. By IL1A and TNF in keratinocytes. Constitutive in articular chondrocytes.

Gene Ontology (GO) - Molecular Function for IL36B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005149 interleukin-1 receptor binding NAS 10744718
genes like me logo Genes that share ontologies with IL36B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL36B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IL36B Gene

Localization for IL36B Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL36B Gene

Secreted.

Gene Ontology (GO) - Cellular Components for IL36B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10744718
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IL36B: view

No data available for Subcellular locations from COMPARTMENTS for IL36B Gene

Pathways for IL36B Gene

genes like me logo Genes that share pathways with IL36B: view

Pathways by source for IL36B Gene

1 R&D Systems pathway for IL36B Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for IL36B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000259213%0d%0a9606.ENSP00000358081%0d%0a
Selected Interacting proteins: ENSP00000259213 for IL36B Gene via STRING

Symbol External ID(s) Details
BAG3

Gene Ontology (GO) - Biological Process for IL36B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response NAS 10744718
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0032755 positive regulation of interleukin-6 production IEA --
genes like me logo Genes that share ontologies with IL36B: view

Transcripts for IL36B Gene

mRNA/cDNA for IL36B Gene

(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL36B Gene

Interleukin 36, beta:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL36B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IL36B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL36B Gene

No ASD Table

Relevant External Links for IL36B Gene

GeneLoc Exon Structure for
IL36B
ECgene alternative splicing isoforms for
IL36B

Expression for IL36B Gene

mRNA expression in normal human tissues for IL36B Gene

mRNA differential expression in normal tissues according to GTEx for IL36B Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (25.3), Skin - Not Sun Exposed (Suprapubic) (15.2), and Esophagus - Mucosa (7.6).

SOURCE GeneReport for Unigene cluster for IL36B Gene Hs.278909

mRNA Expression by UniProt/SwissProt for IL36B Gene

Q9NZH7-IL36B_HUMAN
Tissue specificity: Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue.
genes like me logo Genes that share expressions with IL36B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for IL36B Gene

Orthologs for IL36B Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL36B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL36B 36
  • 31 (a)
OneToOne
LOC100297786 35
  • 74.12 (n)
  • 63.82 (a)
dog
(Canis familiaris)
Mammalia IL36B 36
  • 38 (a)
OneToOne
LOC483068 35
  • 78.29 (n)
  • 68.42 (a)
mouse
(Mus musculus)
Mammalia Il1f8 35
  • 73.42 (n)
  • 64.19 (a)
Il1f8 16
Il1f8 36
  • 30 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 24 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Il36b 35
  • 78.21 (n)
  • 75 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 13 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
-- 36
  • 16 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
Species with no ortholog for IL36B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL36B Gene

ENSEMBL:
Gene Tree for IL36B (if available)
TreeFam:
Gene Tree for IL36B (if available)

Paralogs for IL36B Gene

Paralogs for IL36B Gene

Selected SIMAP similar genes for IL36B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL36B: view

Variants for IL36B Gene

Sequence variations from dbSNP and Humsavar for IL36B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs721870 -- 113,048,229(-) tcacc(A/C)tgttg intron-variant
rs968651 -- 113,038,309(+) CTGAC(C/T)GGGCT intron-variant
rs1006122 -- 113,028,265(-) TAACA(C/G)TCTAA intron-variant
rs1374280 -- 113,039,089(+) CCAGC(C/T)TCCTC intron-variant
rs1446508 -- 113,039,684(+) AAAAT(G/T)AAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL36B Gene

Variant ID Type Subtype PubMed ID
nsv874885 CNV Gain 21882294
nsv874886 CNV Loss 21882294
nsv874887 CNV Loss 21882294
dgv4282n71 CNV Loss 21882294
nsv874889 CNV Gain 21882294
nsv874891 CNV Loss 21882294
nsv2881 CNV Loss 18451855
nsv874892 CNV Loss 21882294
nsv874893 CNV Gain 21882294

Relevant External Links for IL36B Gene

HapMap Linkage Disequilibrium report
IL36B
Human Gene Mutation Database (HGMD)
IL36B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL36B Gene

Disorders for IL36B Gene

(2) Novoseek inferred disease relationships for IL36B Gene

Disease -log(P) Hits PubMed IDs
necrosis 9.06 2
tumors 0 2
genes like me logo Genes that share disorders with IL36B: view

No data available for UniProtKB/Swiss-Prot for IL36B Gene

Publications for IL36B Gene

  1. Four new members expand the IL-1 superfamily. (PMID: 10625660) Smith D.E. … Sims J.E. (J. Biol. Chem. 2000) 2 3 4 23
  2. The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. (PMID: 16646978) Magne D. … Gabay C. (Arthritis Res. Ther. 2006) 2 3 4
  3. IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression. (PMID: 21242515) Johnston A. … Gudjonsson J.E. (J. Immunol. 2011) 3 4
  4. Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36I+, IL-36I^, and IL-36I^) or antagonist (IL-36Ra) activity. (PMID: 21965679) Towne J.E. … Sims J.E. (J. Biol. Chem. 2011) 3 4
  5. IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin. (PMID: 24829417) Foster A.M. … Johnston A. (J. Immunol. 2014) 3 4

Products for IL36B Gene

Sources for IL36B Gene

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