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Aliases for IL36B Gene

Aliases for IL36B Gene

  • Interleukin 36, Beta 2 3 5
  • Interleukin 1 Family, Member 8 (Eta) 2 3
  • Interleukin-1 Family Member 8 3 4
  • Interleukin-1 Homolog 2 3 4
  • Interleukin-1 Eta 3 4
  • FIL1 Eta 3 4
  • IL-1 Eta 3 4
  • IL-1F8 3 4
  • IL-1H2 3 4
  • IL1F8 3 4
  • IL1H2 3 4
  • IL1F8 (Canonical Product IL-1F8a) 3
  • Interleukin-1 Superfamily E 3
  • Family Of Interleukin 1-Eta 3
  • Interleukin 1, Eta 3
  • IL-1F8 (FIL1-Eta) 3
  • FIL1-(ETA) 3
  • FILI-(ETA) 3
  • IL1-ETA 3
  • FIL1H 3
  • FIL1 3

External Ids for IL36B Gene

Previous HGNC Symbols for IL36B Gene

  • IL1F8

Previous GeneCards Identifiers for IL36B Gene

  • GC02M113779

Summaries for IL36B Gene

Entrez Gene Summary for IL36B Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL36B Gene

IL36B (Interleukin 36, Beta) is a Protein Coding gene. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include cytokine activity and interleukin-1 receptor binding. An important paralog of this gene is IL1RN.

UniProtKB/Swiss-Prot for IL36B Gene

  • Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.

Gene Wiki entry for IL36B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL36B Gene

Genomics for IL36B Gene

Genomic Location for IL36B Gene

Chromosome:
2
Start:
113,022,091 bp from pter
End:
113,052,867 bp from pter
Size:
30,777 bases
Orientation:
Minus strand

Genomic View for IL36B Gene

Genes around IL36B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL36B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL36B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL36B Gene

No data available for Regulatory Elements for IL36B Gene

Proteins for IL36B Gene

  • Protein details for IL36B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZH7-IL36B_HUMAN
    Recommended name:
    Interleukin-36 beta
    Protein Accession:
    Q9NZH7
    Secondary Accessions:
    • Q3MIH0
    • Q53SR6
    • Q7RTZ7
    • Q9UHA5

    Protein attributes for IL36B Gene

    Size:
    164 amino acids
    Molecular mass:
    18522 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IL36B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL36B Gene

Proteomics data for IL36B Gene at MOPED

Post-translational modifications for IL36B Gene

  • N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL36B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL36B (IL-36 beta/IL-1F8)
  • Santa Cruz Biotechnology (SCBT) Antibodies for IL36B

No data available for DME Specific Peptides for IL36B Gene

Domains & Families for IL36B Gene

Gene Families for IL36B Gene

Protein Domains for IL36B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL36B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZH7

UniProtKB/Swiss-Prot:

IL36B_HUMAN :
  • Belongs to the IL-1 family.
Family:
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL36B: view

Function for IL36B Gene

Molecular function for IL36B Gene

UniProtKB/Swiss-Prot Function:
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.
UniProtKB/Swiss-Prot Induction:
By proinflammatory cytokines IL1A, IL1B and TNF in synovial fibroblasts. By IL1A and TNF in keratinocytes. Constitutive in articular chondrocytes.
genes like me logo Genes that share phenotypes with IL36B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IL36B

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL36B Gene

Localization for IL36B Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL36B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL36B Gene COMPARTMENTS Subcellular localization image for IL36B gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for IL36B Gene

Pathways & Interactions for IL36B Gene

genes like me logo Genes that share pathways with IL36B: view

Pathways by source for IL36B Gene

1 R&D Systems pathway for IL36B Gene

Interacting Proteins for IL36B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000259213%0d%0a9606.ENSP00000358081%0d%0a
Selected Interacting proteins: ENSP00000259213 for IL36B Gene via STRING

Symbol External ID(s) Details
BAG3

Gene Ontology (GO) - Biological Process for IL36B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 10744718
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0045582 positive regulation of T cell differentiation IEA --
genes like me logo Genes that share ontologies with IL36B: view

No data available for SIGNOR curated interactions for IL36B Gene

Drugs & Compounds for IL36B Gene

No Compound Related Data Available

Transcripts for IL36B Gene

mRNA/cDNA for IL36B Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL36B Gene

Interleukin 36, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL36B Gene

No ASD Table

Relevant External Links for IL36B Gene

GeneLoc Exon Structure for
IL36B
ECgene alternative splicing isoforms for
IL36B

Expression for IL36B Gene

mRNA expression in normal human tissues for IL36B Gene

mRNA differential expression in normal tissues according to GTEx for IL36B Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x25.3), Skin - Not Sun Exposed (Suprapubic) (x15.2), and Esophagus - Mucosa (x7.6).

SOURCE GeneReport for Unigene cluster for IL36B Gene Hs.278909

mRNA Expression by UniProt/SwissProt for IL36B Gene

Q9NZH7-IL36B_HUMAN
Tissue specificity: Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue.
genes like me logo Genes that share expression patterns with IL36B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IL36B Gene

Orthologs for IL36B Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL36B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100297786 35
  • 74.12 (n)
  • 63.82 (a)
IL36B 36
  • 31 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL36B 36
  • 38 (a)
OneToOne
LOC483068 35
  • 78.29 (n)
  • 68.42 (a)
mouse
(Mus musculus)
Mammalia Il1f8 36
  • 30 (a)
OneToOne
Il1f8 16
Il1f8 35
  • 73.42 (n)
  • 64.19 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 24 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Il36b 35
  • 78.21 (n)
  • 75 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 13 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
-- 36
  • 16 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
Species with no ortholog for IL36B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL36B Gene

ENSEMBL:
Gene Tree for IL36B (if available)
TreeFam:
Gene Tree for IL36B (if available)

Paralogs for IL36B Gene

Paralogs for IL36B Gene

(2) SIMAP similar genes for IL36B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL36B: view

Variants for IL36B Gene

Sequence variations from dbSNP and Humsavar for IL36B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs34754959 - 113,031,063(-) TTAGC(C/T)GCAGC reference, missense
rs968651 -- 113,038,309(+) CTGAC(C/T)GGGCT intron-variant
rs1562304 -- 113,028,150(+) GGAGG(A/G)TAGGA intron-variant
rs1992762 -- 113,052,836(+) GGAGA(A/G)GTGAG utr-variant-5-prime
rs1992763 -- 113,053,159(+) CAGGA(A/T)TCTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IL36B Gene

Variant ID Type Subtype PubMed ID
nsv874885 CNV Gain 21882294
nsv874886 CNV Loss 21882294
nsv874887 CNV Loss 21882294
dgv4282n71 CNV Loss 21882294
nsv874889 CNV Gain 21882294
nsv874891 CNV Loss 21882294
nsv2881 CNV Loss 18451855
nsv874892 CNV Loss 21882294
nsv874893 CNV Gain 21882294

Variation tolerance for IL36B Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL36B Gene

HapMap Linkage Disequilibrium report
IL36B
Human Gene Mutation Database (HGMD)
IL36B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL36B Gene

Disorders for IL36B Gene

Relevant External Links for IL36B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL36B

No disorders were found for IL36B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL36B Gene

Publications for IL36B Gene

  1. Four new members expand the IL-1 superfamily. (PMID: 10625660) Smith D.E. … Sims J.E. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. (PMID: 16646978) Magne D. … Gabay C. (Arthritis Res. Ther. 2006) 2 3
  3. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. (PMID: 14734551) Towne J.E. … Sims J.E. (J. Biol. Chem. 2004) 3 23
  4. IL1HY1: a novel interleukin-1 receptor antagonist gene. (PMID: 10512743) Mulero J.J. … Ford J.E. (Biochem. Biophys. Res. Commun. 1999) 2 3
  5. IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin. (PMID: 24829417) Foster A.M. … Johnston A. (J. Immunol. 2014) 3

Products for IL36B Gene

Sources for IL36B Gene

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