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IL36B Gene

protein-coding   GIFtS: 44
GCID: GC02M113779

Interleukin 36, Beta

(Previous names: interleukin 1 family, member 8 (eta))
(Previous symbol: IL1F8)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 36, Beta1 2     FIL1H2 5
IL1F81 2 3 5     FIL12
IL1H22 3 5     FIL1-(ETA)2
Interleukin 1 Family, Member 8 (Eta)1 2     FILI-(ETA)2
Interleukin-1 Eta2 3     IL1-ETA2
Interleukin-1 Family Member 82 3     Family Of Interleukin 1-Eta2
Interleukin-1 Homolog 22 3     IL-1F8 (FIL1-Eta)2
IL-1F82 3     IL1F8 (Canonical Product IL-1F8a)2
IL-1H22 3     Interleukin 1, Eta2
FIL1 Eta2 3     Interleukin-1 Superfamily E2
IL-1 Eta2 3     Interleukin-36 Beta2

External Ids:    HGNC: 155641   Entrez Gene: 271772   Ensembl: ENSG000001366967   OMIM: 6055085   UniProtKB: Q9NZH73   

Export aliases for IL36B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL36B Gene:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling
indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A
(IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene
cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been
reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL36B Gene:
IL36B (interleukin 36, beta) is a protein-coding gene. GO annotations related to this gene include interleukin-1 receptor binding and cytokine activity. An important paralog of this gene is IL36A.

UniProtKB/Swiss-Prot: IL36B_HUMAN, Q9NZH7
Function: Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes
and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and
103 as well as a number of matrix metalloproteases

Gene Wiki entry for IL36B (IL1F8) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IL36B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL36B promoter sequence
   Search Chromatin IP Primers for IL36B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL36B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q14

IL36B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL36B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M113779:  view genomic region     (about GC identifiers)

Start:
113,779,668 bp from pter      End:
113,810,444 bp from pter
Size:
30,777 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IL36B_HUMAN, Q9NZH7 (See protein sequence)
Recommended Name: Interleukin-36 beta  
Size: 164 amino acids; 18522 Da
Secondary accessions: Q3MIH0 Q53SR6 Q7RTZ7 Q9UHA5
Alternative splicing: 2 isoforms:  Q9NZH7-1   Q9NZH7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL36B: NX_Q9NZH7

Explore proteomics data for IL36B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IL36B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_055253.2  NP_775270.1  

    ENSEMBL proteins: 
     ENSP00000259213   ENSP00000328420  

    IL36B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    3 InterPro protein domains:
     IPR000975 IL-1
     IPR027172 IL-36_beta
     IPR008996 Cytokine_IL1-like

    Graphical View of Domain Structure for InterPro Entry Q9NZH7

    ProtoNet protein and cluster: Q9NZH7

    UniProtKB/Swiss-Prot: IL36B_HUMAN, Q9NZH7
    Similarity: Belongs to the IL-1 family


    Find genes that share domains with IL36B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL36B_HUMAN, Q9NZH7
    Function: Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes
    and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and
    103 as well as a number of matrix metalloproteases
    Induction: By proinflammatory cytokines IL1A, IL1B and TNF in synovial fibroblasts. By IL1A and TNF in
    keratinocytes. Constitutive in articular chondrocytes

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005149interleukin-1 receptor binding NAS10744718
         
    Find genes that share ontologies with IL36B           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IL36B

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL36B_HUMAN, Q9NZH7: Secreted (Potential)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS10744718
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IL36B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL36B About    
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    IL-1 Family Signaling Pathways0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL36B
        IL-1 Family Signaling Pathways




        Pathway & Disease-focused RT2 Profiler PCR Array including IL36B: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IL36B

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001819positive regulation of cytokine production ----
    GO:0006954inflammatory response IEA--
    GO:0006955immune response NAS10744718
    GO:0032755positive regulation of interleukin-6 production IEA--
    GO:0045582positive regulation of T cell differentiation IEA--

    Find genes that share ontologies with IL36B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL36B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL36B gene (2 alternative transcripts): 
    NM_014438.4  NM_173178.2  

    Unigene Cluster for IL36B:

    Interleukin 36, beta
    Hs.278909  [show with all ESTs]
    Unigene Representative Sequence: AF200494
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259213(uc002tiq.1) ENST00000327407(uc002tir.1)
    miRNA
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    Additional mRNA sequence: 

    AF200494.1 AF201833.1 BC101831.1 BC101833.1 

    2 DOTS entries:

    DT.91750947  DT.100669905 

    7 AceView cDNA sequences:

    NM_014438 NM_173178 AF201833 AF200494 CA441070 BX283678 BF244205 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL36B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IL36B Expression
    About this image

    IL36B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL36B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.278909

    UniProtKB/Swiss-Prot: IL36B_HUMAN, Q9NZH7
    Tissue specificity: Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but
    not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic
    plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed
    joint tissue

        Pathway & Disease-focused RT2 Profiler PCR Array including IL36B: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL36B gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1f81 , 5 interleukin 1 family, member 81, 5 73.42(n)1
    64.19(a)1
      2 (16.21 cM)5
    696771  NM_027163.41  NP_081439.11 
     241531615 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    16(a)
    15(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343238.1(888698-895870)
    GL343238.1(908975-910584)


    ENSEMBL Gene Tree for IL36B (if available)
    TreeFam Gene Tree for IL36B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL36B gene
    IL36A2  IL372  IL1RN2  IL36RN2  IL1F102  IL36G2  
    2 SIMAP similar genes for IL36B using alignment to 1 protein entry:     IL36B_HUMAN:
    IL36A    IL36G

    Find genes that share paralogs with IL36B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL36B (see all 743)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1417955771,2
    Cuntested1113788731(+) GCCTCC/TCCTGC 4 R syn11Minor allele frequency- T:0.00NA 4548
    rs130335741,2
    C,F--113779206(+) TGTGTC/TGATGT 1 -- ds500111Minor allele frequency- T:0.42NS NA CSA WA EA 466
    rs357571741,2
    C,F--113779307(-) GGACCA/GCAGCA 1 -- ds50016Minor allele frequency- G:0.06NS NA WA CSA 218
    rs1907196371,2
    --113779486(+) GGCTAC/TAATCC 1 -- ds50010--------
    rs118949021,2
    C,F,A,H--113779533(+) ACTCAT/CTGGGA 1 -- ds500119Minor allele frequency- C:0.18NA EA NS WA CSA 830
    rs342503531,2
    C--113779578(-) TCTACC/TATAGG 1 -- ds50013Minor allele frequency- T:0.01NS NA 94
    rs1840984111,2
    --113779697(+) ACCAGC/TGTAAG 1 -- ut310--------
    rs1483775451,2
    --113779786(+) AGAGCA/GTTTCA 1 -- ut310--------
    rs1415540761,2
    --113779807(+) TCTAGC/TGAATA 1 -- ut310--------
    rs48491421,2
    C,F,A,H--113779875(+) CCCCTG/ATACAT 1 -- ut31 ese328Minor allele frequency- A:0.46NS EA NA CSA WA 2846

    HapMap Linkage Disequilibrium report for IL36B (113779668 - 113810444 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for IL36B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv874886CNV Loss21882294
    dgv4282n71CNV Loss21882294
    nsv874892CNV Loss21882294
    nsv2881CNV Loss18451855
    nsv874887CNV Loss21882294
    nsv874891CNV Loss21882294
    nsv874893CNV Gain21882294
    nsv874889CNV Gain21882294
    nsv874885CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605508    OMIM disorders: --


    Find genes that share disorders with IL36B           About GenesLikeMe

    2 Novoseek inferred disease relationships for IL36B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 9.06 2 2187465 (1), 14696431 (1)
    tumors 0 3 2187465 (1), 14696431 (1)


    Export disorders for IL36B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL36B gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with IL36B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Four new members expand the IL-1 superfamily. (PubMed id 10625660)1, 2, 3, 9 Smith D.E....Sims J.E. (J. Biol. Chem. 2000)
    2. The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. (PubMed id 16646978)1, 2, 3 Magne D.... Gabay C. (Arthritis Res. Ther. 2006)
    3. IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression. (PubMed id 21242515)1, 2 Johnston A.... Gudjonsson J.E. (J. Immunol. 2011)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. A sequence-based map of the nine genes of the human interleukin-1 cluster. (PubMed id 11991722)1, 2 Nicklin M.J.H....Kornman K. (Genomics 2002)
    6. Identification and initial characterization of four novel members of the interleukin-1 family. (PubMed id 10744718)1, 2 Kumar S....Young P.R. (J. Biol. Chem. 2000)
    7. IL1HY1: a novel interleukin-1 receptor antagonist gene. (PubMed id 10512743)1, 3 Mulero J.J.... Ford J.E. (Biochem. Biophys. Res. Commun. 1999)
    8. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. (PubMed id 14734551)1, 9 Towne J.E....Sims J.E. (J. Biol. Chem. 2004)
    9. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    10. Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36I+, IL-36I^, and IL-36I^) or antagonist (IL-36Ra) activity. (PubMed id 21965679)1 Towne J.E....Sims J.E. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27177 HGNC: 15564 AceView: IL1F8 Ensembl:ENSG00000136696 euGenes: HUgn27177
    ECgene: IL36B H-InvDB: IL36B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IL36B Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
    SeattleSNPshttp://pga.gs.washington.edu/data/il1f8/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL36B gene:
    Search GeneIP for patents involving IL36B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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