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IL36A Gene

protein-coding   GIFtS: 48
GCID: GC02P113764

Interleukin 36, Alpha

(Previous names: interleukin 1 family, member 6 (epsilon))
(Previous symbol: IL1F6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 36, Alpha1 2     IL-1 Epsilon2 3
IL1F61 2 3 5     FIL12
FIL1E2 3 5     FIL1(EPSILON)2
Interleukin 1 Family, Member 6 (Epsilon)1 2     IL1(EPSILON)2
Interleukin-1 Epsilon2 3     IL-1F6 (FIL-1-Epsilon)2
Interleukin-1 Family Member 62 3     Interleukin 1, Epsilon2
IL-1F62 3     Interleukin-36 Alpha2
FIL1 Epsilon2 3     IL1E3

External Ids:    HGNC: 155621   Entrez Gene: 271792   Ensembl: ENSG000001366947   OMIM: 6055095   UniProtKB: Q9UHA73   

Export aliases for IL36A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IL36A Gene:
IL36A (interleukin 36, alpha) is a protein-coding gene. GO annotations related to this gene include interleukin-1 receptor binding and cytokine activity. An important paralog of this gene is IL36B.

Gene Wiki entry for IL36A (IL1F6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IL36A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL36A promoter sequence
   Search Chromatin IP Primers for IL36A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL36A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12-q14.1   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q12-q14.1

IL36A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL36A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P113764:  view genomic region     (about GC identifiers)

Start:
113,763,038 bp from pter      End:
113,765,621 bp from pter
Size:
2,584 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IL36A_HUMAN, Q9UHA7 (See protein sequence)
Recommended Name: Interleukin-36 alpha  
Size: 158 amino acids; 17684 Da
Miscellaneous: Binding analysis failed to detect interaction with multiple IL1R family members
Secondary accessions: B2RAD9 Q53SR7 Q5BLR4 Q7RTZ8

Explore the universe of human proteins at neXtProt for IL36A: NX_Q9UHA7

Explore proteomics data for IL36A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IL36A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055255.1  
    ENSEMBL proteins: 
     ENSP00000259211  

    IL36A Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    5 InterPro protein domains:
     IPR027163 IL-36_alpha
     IPR003296 IL-1_beta
     IPR000975 IL-1
     IPR008996 Cytokine_IL1-like
     IPR003294 IL-1_alpha/beta

    Graphical View of Domain Structure for InterPro Entry Q9UHA7

    ProtoNet protein and cluster: Q9UHA7

    1 Blocks protein domain: IPB000975 Interleukin-1 precursor family signature

    UniProtKB/Swiss-Prot: IL36A_HUMAN, Q9UHA7
    Similarity: Belongs to the IL-1 family


    Find genes that share domains with IL36A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005149interleukin-1 receptor binding NAS10625660
         
    Find genes that share ontologies with IL36A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IL36A:
     Increased HPV18 LCR reporter a 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IL36A

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL36A_HUMAN, Q9UHA7: Secreted (Potential)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS10625660
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IL36A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL36A About    
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    IL-1 Family Signaling Pathways0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL36A
        IL-1 Family Signaling Pathways




        Pathway & Disease-focused RT2 Profiler PCR Array including IL36A: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IL36A

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001819positive regulation of cytokine production ----
    GO:0006954inflammatory response IEA--
    GO:0006955immune response NAS10625660
    GO:0032755positive regulation of interleukin-6 production IEA--

    Find genes that share ontologies with IL36A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL36A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL36A gene: 
    NM_014440.1  

    Unigene Cluster for IL36A:

    Interleukin 36, alpha
    Hs.278910
    Unigene Representative Sequence: AK314149
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000259211(uc010yxr.2)
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    Additional mRNA sequence: 

    AF201831.1 AK314149.1 BC107042.1 BC107043.1 

    1 DOTS entry:

    DT.91670531 

    2 AceView cDNA sequences:

    AF201831 NM_014440 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL36A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAGACCCT
    IL36A Expression
    About this image


    IL36A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
    IL36A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL36A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.278910

    UniProtKB/Swiss-Prot: IL36A_HUMAN, Q9UHA7
    Tissue specificity: Expressed in immune system and fetal brain, but not in other tissues tested or in multiple
    hematopoietic cell lines

        Pathway & Disease-focused RT2 Profiler PCR Array including IL36A: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL36A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL36A gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1f61 , 5 interleukin 1 family, member 61, 5 68.8(n)1
    54.49(a)1
      2 (16.26 cM)5
    544481  NM_019450.31  NP_062323.11 
     242154185 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    33(a)
    31(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343238.1(908975-910584)
    GL343238.1(853473-859585)


    ENSEMBL Gene Tree for IL36A (if available)
    TreeFam Gene Tree for IL36A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL36A gene
    IL36B2  IL372  IL1RN2  IL36RN2  IL1F102  IL36G2  
    5 SIMAP similar genes for IL36A using alignment to 1 protein entry:     IL36A_HUMAN:
    IL36G    IL36B    IL36RN    IL37    IL1F10

    Find genes that share paralogs with IL36A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL36A (see all 110)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476998091,2
    --113761452(+) TTAAGA/TTTTTT 1 -- us2k10--------
    rs10204041,2
    C,F,A--113761473(-) tcagcC/Ttacac 1 -- us2k115Minor allele frequency- T:0.19NS NA WA CSA EA 455
    rs1491526761,2
    --113761808(+) CAAACC/TGATGT 1 -- us2k10--------
    rs1422782591,2
    --113761832(+) GTGCCA/TCAAAC 1 -- us2k10--------
    rs1838007351,2
    --113761860(+) CCTTAA/TAACAA 1 -- us2k10--------
    rs1875775261,2
    --113761882(+) TTTATG/TTTGGT 1 -- us2k10--------
    rs133828781,2
    C,F--113761931(+) atatgC/Tatttt 1 -- us2k14Minor allele frequency- T:0.14NA NS WA 210
    rs1920261451,2
    --113762152(+) AGGGAA/GATGCT 1 -- us2k10--------
    rs289939691,2
    C,F--113762224(+) CCAGCT/CCCAGG 1 -- us2k19Minor allele frequency- C:0.12NS NA WA CSA 337
    rs126202931,2
    C,F,H--113762279(+) tgcccG/Ccggcc 1 -- us2k11Minor allele frequency- C:0.50NA 4

    HapMap Linkage Disequilibrium report for IL36A (113763038 - 113765621 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL36A:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4281n71CNV Loss21882294
    nsv874878CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL36A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605509    OMIM disorders: --


    Find genes that share disorders with IL36A           About GenesLikeMe


    Export disorders for IL36A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL36A gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with IL36A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Four new members expand the IL-1 superfamily. (PubMed id 10625660)1, 2, 3, 9 Smith D.E....Sims J.E. (J. Biol. Chem. 2000)
    2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PubMed id 16777052)1, 2, 9 Zhan X. and Desiderio D.M. (Anal. Biochem. 2006)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A sequence-based map of the nine genes of the human interleukin-1 cluster. (PubMed id 11991722)1, 2 Nicklin M.J.H....Kornman K. (Genomics 2002)
    6. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. (PubMed id 14734551)1, 9 Towne J.E....Sims J.E. (J. Biol. Chem. 2004)
    7. Decreased expression of interleukin-36I+ correlates with poor prognosis in hepatocellular carcinoma. (PubMed id 24061617)1 Pan Q.Z....Xia J.C. (Cancer Immunol. Immunother. 2013)
    8. The novel cytokine interleukin-36I+ is expressed in psoriatic and rheumatoid arthritis synovium. (PubMed id 23268368)1 Frey S....Hueber A.J. (Ann. Rheum. Dis. 2013)
    9. Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36I+, IL-36I^, and IL-36I^) or antagonist (IL-36Ra) activity. (PubMed id 21965679)1 Towne J.E....Sims J.E. (J. Biol. Chem. 2011)
    10. IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression. (PubMed id 21242515)1 Johnston A.... Gudjonsson J.E. (J. Immunol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27179 HGNC: 15562 AceView: IL1F6 Ensembl:ENSG00000136694 euGenes: HUgn27179
    ECgene: IL36A H-InvDB: IL36A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL36A Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
    SeattleSNPshttp://pga.gs.washington.edu/data/il1f6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL36A gene:
    Search GeneIP for patents involving IL36A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Block miRNA regulation of human, mouse, rat IL36A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IL36A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL36A Predesigned siRNA for gene silencing in human, mouse, rat IL36A
     QuantiFast Probe-based Assays in human, mouse, rat IL36A QuantiTect SYBR Green Assays in human, mouse, rat IL36A
     PCR Arrays including human, mouse, rat IL36A Search Chromatin IP Primers for IL36A
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     Browse ESI BIO Cell Lines and PureStem Progenitors for IL36A
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for IL36A
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     Browse compounds at ApexBio
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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