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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL36A Gene

protein-coding   GIFtS: 47
GCID: GC02P113764

interleukin 36, alpha

(Previous names: interleukin 1 family, member 6 (epsilon) )
(Previous symbol: IL1F6)
 Explore 9 diseases affiliated with
IL36A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IL36A    

Aliases
for IL36A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interleukin 36, Alpha1 2     FIL1 Epsilon2 3
FIL1E1 2 3 5     IL-1 Epsilon2 3
IL1F61 2 3 5     MGC1295521
IL-1F61 2 3     MGC1295531
FIL11 2     FIL1(EPSILON)2
IL1(EPSILON)1 2     IL-1F6 (FIL-1-Epsilon)2
Interleukin 1 Family, Member 6 (Epsilon)1 2     Interleukin 1, Epsilon2
Interleukin-1 Epsilon2 3     Interleukin-36 Alpha2
Interleukin-1 Family Member 62 3     IL1E3

External Ids:    HGNC: 155621   Entrez Gene: 271792   Ensembl: ENSG000001366947   OMIM: 6055095   UniProtKB: Q9UHA73   

Export aliases for IL36A gene to outside databases


Summaries
for IL36A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for IL36A (IL1F6)


Genomic Views
for IL36A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022135.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IL36A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL36A promoter sequence
   Search SABiosciences Chromatin IP Primers for IL36A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL36A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12-q14.1   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q12-q14.1

IL36A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL36A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P113764:  view genomic region     (about GC identifiers)

Start:
 113,763,038 bp from pter      End:
 113,765,621 bp from pter
Size:
 2,584 bases      Orientation:
 plus strand

Proteins
for IL36A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IL36A_HUMAN, Q9UHA7 (See protein sequence)
Recommended Name: Interleukin-36 alpha  
Size: 158 amino acids; 17684 Da
Subcellular location: Secreted (Potential)
Miscellaneous: Binding analysis failed to detect interaction with multiple IL1R family members
Secondary accessions: B2RAD9 Q53SR7 Q5BLR4 Q7RTZ8

Explore the universe of human proteins at neXtProt for IL36A: NX_Q9UHA7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UHA7

    • IL36A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055255.1  
    ENSEMBL proteins: 
     ENSP00000259211  

    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for IL36A
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS10625660
    GO:0005615extracellular space IEA--


    IL36A for ontologies           About GeneDecksing



    IL36A Antibody Products: 
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    Protein Domains /
    Families
    for IL36A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IL36A for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR027163 Interleukin-36_alpha
     IPR008996 Cytokine_IL1-like
     IPR003296 InterleukinIL1B
     IPR000975 Interleukin_1
     IPR003294 InterleukinIL1AB

    Graphical View of Domain Structure for InterPro Entry Q9UHA7

    ProtoNet protein and cluster: Q9UHA7

    1 Blocks protein family: IPB000975 Interleukin-1 precursor family signature

    UniProtKB/Swiss-Prot: IL36A_HUMAN, Q9UHA7
    Similarity: Belongs to the IL-1 family


    Function
    for IL36A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: IL36A
    OriGene siRNA: IL36A
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IL36A

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005149interleukin-1 receptor binding NAS10625660


    IL36A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for IL36A:
     Increased HPV18 LCR reporter a 


    Pathways & Interactions
    for IL36A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL36A

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0006955immune response NAS10625660


    IL36A for ontologies           About GeneDecksing



    Drugs & Compounds
    for IL36A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL36A
    Search CenterWatch for drugs/clinical trials and news about IL36A 

    Transcripts
    for IL36A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IL36A gene: 
    NM_014440.1  

    Unigene Cluster for IL36A:

    Interleukin 36, alpha
    Hs.278910
    Unigene Representative Sequence: AK314149
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000259211(uc010yxr.2)

    miRNA
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL36A (see all 4)
    OriGene shRNA RFP: IL36A
    OriGene siRNA: IL36A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL36A
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL36A 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL36A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL36A

    Additional cDNA sequence: 

    AF201831.1 AK314149.1 BC107042.1 BC107043.1 

    1 DOTS entry:

    DT.91670531 

    2 AceView cDNA sequences:

    NM_014440 AF201831 

    GeneLoc Exon Structure


    Expression
    for IL36A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL36A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGAGACCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IL36A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSertoli cellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IL36A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL36A

    SOURCE GeneReport for Unigene cluster: Hs.278910

    UniProtKB/Swiss-Prot: IL36A_HUMAN, Q9UHA7
    Tissue specificity: Expressed in immune system and fetal brain, but not in other tissues tested or in multiple
    hematopoietic cell lines

        SABiosciences Expression via Pathway-Focused PCR Array including IL36A: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL36A
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IL36A

    Orthologs
    for IL36A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IL36A gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 32(a)
    31(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 GL343238.1(853473-858000)
    GL343238.1(908975-910584)


    ENSEMBL Gene Tree for IL36A (if available)
    TreeFam Gene Tree for IL36A (if available) 

    Paralogs
    for IL36A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL36A gene
    IL372  IL1RN2  IL36RN2  IL36G2  IL1F102  
    5 SIMAP similar genes for IL36A using alignment to 1 protein entry:     IL36A_HUMAN:
    IL36G    IL36B    IL36RN    IL37    IL1F10

    IL36A for paralogs           About GeneDecksing



    Genomic Variants
    for IL36A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/75 NCBI SNPs in IL36A are shown (see all 75)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1476998091,2
    		--113761452(+) TTAAGA/TTTTTT 1 -- us2k10--------
    rs10204041,2
    		C,F,A,--113761473(-) TCAGCC/TTACAC 1 -- us2k115Minor allele frequency- T:0.19NS NA WA CSA EA 455
    rs1491526761,2
    		--113761808(+) CAAACC/TGATGT 1 -- us2k10--------
    rs1422782591,2
    		--113761832(+) GTGCCA/TCAAAC 1 -- us2k10--------
    rs1838007351,2
    		--113761860(+) CCTTAA/TAACAA 1 -- us2k10--------
    rs1875775261,2
    		--113761882(+) TTTATG/TTTGGT 1 -- us2k10--------
    rs133828781,2
    		C,F,--113761931(+) atatgC/Tatttt 1 -- us2k14Minor allele frequency- T:0.14NA NS WA 210
    rs1920261451,2
    		--113762152(+) AGGGAA/GATGCT 1 -- us2k10--------
    rs289939691,2
    		C,F,--113762224(+) CCAGCT/CCCAGG 1 -- us2k19Minor allele frequency- C:0.12NS NA WA CSA 337
    rs126202931,2
    		C,F,H,--113762279(+) tgcccG/Ccggcc 1 -- us2k11Minor allele frequency- C:0.50NA 4

    HapMap Linkage Disequilibrium report for IL36A (113763038 - 113765621 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IL36A: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL36A
    DNA2.0 Custom Variant and Variant Library Synthesis for IL36A

    Disorders / Diseases
    for IL36A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IL36A for disorders           About GeneDecksing

    OMIM gene information: 605509    OMIM disorders: --

    9 diseases for IL36A:    About MalaCards
    ankylosing spondylitis    pituitary adenoma    spondylitis    rheumatoid arthritis
    hepatitis b    adenoma    arthritis    psoriasis
    hepatitis


    Export disorders for IL36A gene to outside databases

    Publications
    for IL36A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL36A gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with IL36A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Four new members expand the IL-1 superfamily. (PubMed id 10625660)1, 2, 3, 9 Smith D.E....Sims J.E. (2000)
    2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PubMed id 16777052)1, 2, 9 Zhan X. and Desiderio D.M. (2006)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A sequence-based map of the nine genes of the human interleukin-1 cluster. (PubMed id 11991722)1, 2 Nicklin M.J.H....Kornman K. (2002)
    6. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. (PubMed id 14734551)1, 9 Towne J.E....Sims J.E. (2004)
    7. Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36a, IL-36b, and IL-36g) or antagonist (IL-36Ra) activity. (PubMed id 21965679)1 Towne J.E....Sims J.E. (2011)
    8. IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression. (PubMed id 21242515)1 Johnston A.... Gudjonsson J.E. (2011)
    9. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    10. The interleukin-1 family gene polymorphisms in Korean patients with rheumatoid arthritis. (PubMed id 20141484)1 Jung M.Y....Chung J.H. (2010)

    External Searches for IL36A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IL36A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27179 HGNC: 15562 AceView: IL1F6 Ensembl:ENSG00000136694 euGenes: HUgn27179
    ECgene: IL36A H-InvDB: IL36A

    Other Databases showing IL36A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IL36A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL36A Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
    SeattleSNPshttp://pga.gs.washington.edu/data/il1f6/

    Intellectual Property
    for IL36A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IL36A gene:
    Search GeneIP for patents involving IL36A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IL36A gene

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    Advanced Cell Diagnostics
    About This Section

     
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