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Aliases for IL36A Gene

Aliases for IL36A Gene

  • Interleukin 36, Alpha 2 3
  • IL1F6 3 4 6
  • FIL1E 3 4 6
  • Interleukin 1 Family, Member 6 (Epsilon) 2 3
  • Interleukin-1 Family Member 6 3 4
  • Interleukin-1 Epsilon 3 4
  • FIL1 Epsilon 3 4
  • IL-1 Epsilon 3 4
  • IL-1F6 3 4
  • IL-1F6 (FIL-1-Epsilon) 3
  • Interleukin 1, Epsilon 3
  • Interleukin-36 Alpha 3
  • FIL1(EPSILON) 3
  • IL1(EPSILON) 3
  • FIL1 3
  • IL1E 4

External Ids for IL36A Gene

Previous Symbols for IL36A Gene

  • IL1F6

Summaries for IL36A Gene

GeneCards Summary for IL36A Gene

IL36A (Interleukin 36, Alpha) is a Protein Coding gene. Among its related pathways are NOD-like Receptor Signaling Pathways. GO annotations related to this gene include cytokine activity and interleukin-1 receptor binding. An important paralog of this gene is IL1RN.

UniProtKB/Swiss-Prot for IL36A Gene

  • Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T cell proliferation. May play a role in proinflammatory effects in the lung.

Gene Wiki entry for IL36A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL36A Gene

Genomics for IL36A Gene

Genomic Location for IL36A Gene

Start:
113,005,461 bp from pter
End:
113,008,644 bp from pter
Size:
3,184 bases
Orientation:
Plus strand

Genomic View for IL36A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL36A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL36A Gene

No data available for Regulatory Elements for IL36A Gene

Proteins for IL36A Gene

  • Protein details for IL36A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHA7-IL36A_HUMAN
    Recommended name:
    Interleukin-36 alpha
    Protein Accession:
    Q9UHA7
    Secondary Accessions:
    • B2RAD9
    • Q53SR7
    • Q5BLR4
    • Q7RTZ8

    Protein attributes for IL36A Gene

    Size:
    158 amino acids
    Molecular mass:
    17684 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Initial experiments using non-processed full length protein found in vitro activity only in the ug range.

neXtProt entry for IL36A Gene

Proteomics data for IL36A Gene at MOPED

Post-translational modifications for IL36A Gene

  • N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL36A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL36A Gene

Domains for IL36A Gene

Gene Families for IL36A Gene

HGNC:
  • IL :Interleukins and interleukin receptors

UniProtKB/Swiss-Prot:

IL36A_HUMAN
Family:
  • Belongs to the IL-1 family.:
    • Q9UHA7
genes like me logo Genes that share domains with IL36A: view

Function for IL36A Gene

Molecular function for IL36A Gene

UniProtKB/Swiss-Prot Function: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T cell proliferation. May play a role in proinflammatory effects in the lung.
UniProtKB/Swiss-Prot Induction: By Il-1 and TNF-alpha.

Gene Ontology (GO) - Molecular Function for IL36A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005149 interleukin-1 receptor binding NAS 10625660
genes like me logo Genes that share ontologies with IL36A: view

Phenotypes for IL36A Gene

GenomeRNAi human phenotypes for IL36A:
genes like me logo Genes that share phenotypes with IL36A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IL36A Gene

Localization for IL36A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL36A Gene

Secreted.

Gene Ontology (GO) - Cellular Components for IL36A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 10625660
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IL36A: view

Pathways for IL36A Gene

genes like me logo Genes that share pathways with IL36A: view

Pathways by source for IL36A Gene

1 R&D Systems pathway for IL36A Gene

Interacting Proteins for IL36A Gene

Gene Ontology (GO) - Biological Process for IL36A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response NAS 10625660
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0032755 positive regulation of interleukin-6 production IEA --
genes like me logo Genes that share ontologies with IL36A: view

Transcripts for IL36A Gene

mRNA/cDNA for IL36A Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL36A Gene

Interleukin 36, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL36A Gene

No ASD Table

Relevant External Links for IL36A Gene

GeneLoc Exon Structure for
IL36A
ECgene alternative splicing isoforms for
IL36A

Expression for IL36A Gene

mRNA expression in normal human tissues for IL36A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL36A Gene

This gene is overexpressed in Esophagus - Mucosa (44.3) and Minor Salivary Gland (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IL36A Gene

SOURCE GeneReport for Unigene cluster for IL36A Gene Hs.278910

mRNA Expression by UniProt/SwissProt for IL36A Gene

Q9UHA7-IL36A_HUMAN
Tissue specificity: Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin.
genes like me logo Genes that share expressions with IL36A: view

Orthologs for IL36A Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL36A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL1F6 36
  • 99.16 (n)
  • 99.37 (a)
IL36A 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL36A 36
  • 76.39 (n)
  • 70.83 (a)
IL36A 37
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il1f6 36
  • 68.8 (n)
  • 54.49 (a)
Il1f6 16
Il1f6 37
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 40 (a)
ManyToMany
-- 37
  • 44 (a)
ManyToMany
-- 37
  • 40 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 41 (a)
ManyToMany
-- 37
  • 37 (a)
ManyToMany
-- 37
  • 34 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Il36a 36
  • 68.38 (n)
  • 57.05 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 26 (a)
ManyToMany
-- 37
  • 31 (a)
ManyToMany
-- 37
  • 25 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
Species with no ortholog for IL36A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL36A Gene

ENSEMBL:
Gene Tree for IL36A (if available)
TreeFam:
Gene Tree for IL36A (if available)

Paralogs for IL36A Gene

Paralogs for IL36A Gene

Selected SIMAP similar genes for IL36A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL36A: view

Variants for IL36A Gene

Sequence variations from dbSNP and Humsavar for IL36A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs895497 - 113,005,998(-) TCCCC(C/T)GCTGA reference, missense
rs1020404 -- 113,003,896(-) tcagc(C/T)tacac upstream-variant-2KB
rs1026022 -- 113,003,527(-) CCAGA(G/T)GCCCC upstream-variant-2KB
rs1026023 -- 113,003,508(-) GAGCT(C/T)GCAGT upstream-variant-2KB
rs1446511 -- 113,004,966(-) CATGG(A/G)AGAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IL36A Gene

Variant ID Type Subtype PubMed ID
nsv874878 CNV Gain 21882294
dgv4281n71 CNV Loss 21882294

Relevant External Links for IL36A Gene

HapMap Linkage Disequilibrium report
IL36A

Disorders for IL36A Gene

No disorders were found for IL36A Gene.

No data available for UniProtKB/Swiss-Prot for IL36A Gene

Publications for IL36A Gene

  1. Four new members expand the IL-1 superfamily. (PMID: 10625660) Smith D.E. … Sims J.E. (J. Biol. Chem. 2000) 2 3 4 23
  2. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. (PMID: 14734551) Towne J.E. … Sims J.E. (J. Biol. Chem. 2004) 3 4 23
  3. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X. … Desiderio D.M. (Anal. Biochem. 2006) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for IL36A Gene

Sources for IL36A Gene

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