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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL36A Gene

protein-coding   GIFtS: 48
GCID: GC02P113764

Interleukin 36, Alpha

(Previous names: interleukin 1 family, member 6 (epsilon))
(Previous symbol: IL1F6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 36, Alpha1 2     IL-1 Epsilon2 3
IL1F61 2 3 5     FIL12
FIL1E2 3 5     FIL1(EPSILON)2
Interleukin 1 Family, Member 6 (Epsilon)1 2     IL1(EPSILON)2
Interleukin-1 Epsilon2 3     IL-1F6 (FIL-1-Epsilon)2
Interleukin-1 Family Member 62 3     Interleukin 1, Epsilon2
IL-1F62 3     Interleukin-36 Alpha2
FIL1 Epsilon2 3     IL1E3

External Ids:    HGNC: 155621   Entrez Gene: 271792   Ensembl: ENSG000001366947   OMIM: 6055095   UniProtKB: Q9UHA73   

Export aliases for IL36A gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IL36A Gene: 
IL36A (interleukin 36, alpha) is a protein-coding gene. Diseases associated with IL36A include ankylosing spondylitis, and spondylitis. GO annotations related to this gene include interleukin-1 receptor binding and cytokine activity. An important paralog of this gene is IL36B.

Gene Wiki entry for IL36A (IL1F6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  NC_018913.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IL36A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL36A promoter sequence
   Search SABiosciences Chromatin IP Primers for IL36A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL36A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12-q14.1   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q12-q14.1

IL36A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL36A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P113764:  view genomic region     (about GC identifiers)

Start:
113,763,038 bp from pter      End:
113,765,621 bp from pter
Size:
2,584 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL36A_HUMAN, Q9UHA7 (See protein sequence)
Recommended Name: Interleukin-36 alpha  
Size: 158 amino acids; 17684 Da
Subcellular location: Secreted (Potential)
Miscellaneous: Binding analysis failed to detect interaction with multiple IL1R family members
Secondary accessions: B2RAD9 Q53SR7 Q5BLR4 Q7RTZ8

Explore the universe of human proteins at neXtProt for IL36A: NX_Q9UHA7

Explore proteomics data for IL36A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UHA7

  • IL36A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL36A Protein Expression
    REFSEQ proteins: NP_055255.1  
    ENSEMBL proteins: 
     ENSP00000259211  

    Human Recombinant Protein Products for IL36A: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS10625660
    GO:0005615extracellular space IEA--

    IL36A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    5 InterPro protein domains:
     IPR027163 Interleukin-36_alpha
     IPR003296 InterleukinIL1B
     IPR000975 Interleukin_1
     IPR008996 Cytokine_IL1-like
     IPR003294 InterleukinIL1AB

    Graphical View of Domain Structure for InterPro Entry Q9UHA7

    ProtoNet protein and cluster: Q9UHA7

    1 Blocks protein domain: IPB000975 Interleukin-1 precursor family signature

    UniProtKB/Swiss-Prot: IL36A_HUMAN, Q9UHA7
    Similarity: Belongs to the IL-1 family


    IL36A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005149interleukin-1 receptor binding NAS10625660
         
    IL36A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL36A:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL36A 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL36A

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001819positive regulation of cytokine production ----
    GO:0006954inflammatory response IEA--
    GO:0006955immune response NAS10625660
    GO:0032755positive regulation of interleukin-6 production IEA--

    IL36A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL36A

    Search CenterWatch for drugs/clinical trials and news about IL36A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL36A gene: 
    NM_014440.1  

    Unigene Cluster for IL36A:

    Interleukin 36, alpha
    Hs.278910
    Unigene Representative Sequence: AK314149
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000259211(uc010yxr.2)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL36A

    Additional mRNA sequence: 

    AF201831.1 AK314149.1 BC107042.1 BC107043.1 

    1 DOTS entry:

    DT.91670531 

    2 AceView cDNA sequences:

    AF201831 NM_014440 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL36A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAGACCCT
    IL36A Expression
    About this image


    See IL36A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL36A

    SOURCE GeneReport for Unigene cluster: Hs.278910

    UniProtKB/Swiss-Prot: IL36A_HUMAN, Q9UHA7
    Tissue specificity: Expressed in immune system and fetal brain, but not in other tissues tested or in multiple
    hematopoietic cell lines

        SABiosciences Expression via Pathway-Focused PCR Array including IL36A: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL36A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL36A gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1f61 , 5 interleukin 1 family, member 61, 5 68.8(n)1
    54.49(a)1
      2 (16.26 cM)5
    544481  NM_019450.31  NP_062323.11 
     242154185 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    31(a)
    30(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343238.1(908975-910584)
    GL343238.1(853473-859585)


    ENSEMBL Gene Tree for IL36A (if available)
    TreeFam Gene Tree for IL36A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL36A gene
    IL36B2  IL372  IL1RN2  IL36RN2  IL1F102  IL36G2  
    5 SIMAP similar genes for IL36A using alignment to 1 protein entry:     IL36A_HUMAN:
    IL36G    IL36B    IL36RN    IL37    IL1F10

    IL36A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/110 SNPs in IL36A are shown (see all 110)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476998091,2
    --113761452(+) TTAAGA/TTTTTT 1 -- us2k10--------
    rs10204041,2
    C,F,A--113761473(-) tcagcC/Ttacac 1 -- us2k115Minor allele frequency- T:0.19NS NA WA CSA EA 455
    rs1491526761,2
    --113761808(+) CAAACC/TGATGT 1 -- us2k10--------
    rs1422782591,2
    --113761832(+) GTGCCA/TCAAAC 1 -- us2k10--------
    rs1838007351,2
    --113761860(+) CCTTAA/TAACAA 1 -- us2k10--------
    rs1875775261,2
    --113761882(+) TTTATG/TTTGGT 1 -- us2k10--------
    rs133828781,2
    C,F--113761931(+) atatgC/Tatttt 1 -- us2k14Minor allele frequency- T:0.14NA NS WA 210
    rs1920261451,2
    --113762152(+) AGGGAA/GATGCT 1 -- us2k10--------
    rs289939691,2
    C,F--113762224(+) CCAGCT/CCCAGG 1 -- us2k19Minor allele frequency- C:0.12NS NA WA CSA 337
    rs126202931,2
    C,F,H--113762279(+) tgcccG/Ccggcc 1 -- us2k11Minor allele frequency- C:0.50NA 4

    HapMap Linkage Disequilibrium report for IL36A (113763038 - 113765621 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL36A:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv4281n71CNV Loss21882294
    nsv874878CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605509    OMIM disorders: --

    9 diseases for IL36A:    About MalaCards
    ankylosing spondylitis    spondylitis    pituitary adenoma    psoriasis
    adenoma    hepatitis b    rheumatoid arthritis    arthritis
    hepatitis


    IL36A for disorders           About GeneDecksing


    Export disorders for IL36A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL36A gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with IL36A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Four new members expand the IL-1 superfamily. (PubMed id 10625660)1, 2, 3, 9 Smith D.E....Sims J.E. (2000)
    2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PubMed id 16777052)1, 2, 9 Zhan X. and Desiderio D.M. (2006)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A sequence-based map of the nine genes of the human interleukin-1 cluster. (PubMed id 11991722)1, 2 Nicklin M.J.H....Kornman K. (2002)
    6. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. (PubMed id 14734551)1, 9 Towne J.E....Sims J.E. (2004)
    7. Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36a, IL-36b, and IL-36g) or antagonist (IL-36Ra) activity. (PubMed id 21965679)1 Towne J.E....Sims J.E. (2011)
    8. IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression. (PubMed id 21242515)1 Johnston A.... Gudjonsson J.E. (2011)
    9. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    10. The interleukin-1 family gene polymorphisms in Korean patients with rheumatoid arthritis. (PubMed id 20141484)1 Jung M.Y....Chung J.H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27179 HGNC: 15562 AceView: IL1F6 Ensembl:ENSG00000136694 euGenes: HUgn27179
    ECgene: IL36A H-InvDB: IL36A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL36A Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
    SeattleSNPshttp://pga.gs.washington.edu/data/il1f6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL36A gene:
    Search GeneIP for patents involving IL36A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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