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Aliases for IL36A Gene

Aliases for IL36A Gene

  • Interleukin 36, Alpha 2 3 5
  • Interleukin 1 Family, Member 6 (Epsilon) 2 3
  • Interleukin-1 Family Member 6 3 4
  • Interleukin-1 Epsilon 3 4
  • FIL1 Epsilon 3 4
  • IL-1 Epsilon 3 4
  • IL-1F6 3 4
  • IL1F6 3 4
  • FIL1E 3 4
  • IL-1F6 (FIL-1-Epsilon) 3
  • Interleukin 1, Epsilon 3
  • FIL1(EPSILON) 3
  • IL1(EPSILON) 3
  • FIL1 3
  • IL1E 4

External Ids for IL36A Gene

Previous HGNC Symbols for IL36A Gene

  • IL1F6

Previous GeneCards Identifiers for IL36A Gene

  • GC02P113764

Summaries for IL36A Gene

Entrez Gene Summary for IL36A Gene

  • The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]

GeneCards Summary for IL36A Gene

IL36A (Interleukin 36, Alpha) is a Protein Coding gene. Diseases associated with IL36A include psoriasis. Among its related pathways are Toll-Like receptor Signaling Pathways and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include cytokine activity and interleukin-1 receptor binding. An important paralog of this gene is IL1RN.

UniProtKB/Swiss-Prot for IL36A Gene

  • Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T cell proliferation. May play a role in proinflammatory effects in the lung.

Gene Wiki entry for IL36A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL36A Gene

Genomics for IL36A Gene

Regulatory Elements for IL36A Gene

Enhancers for IL36A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL36A on UCSC Golden Path with GeneCards custom track

Genomic Location for IL36A Gene

Chromosome:
2
Start:
113,005,461 bp from pter
End:
113,011,071 bp from pter
Size:
5,611 bases
Orientation:
Plus strand

Genomic View for IL36A Gene

Genes around IL36A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL36A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL36A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL36A Gene

Proteins for IL36A Gene

  • Protein details for IL36A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHA7-IL36A_HUMAN
    Recommended name:
    Interleukin-36 alpha
    Protein Accession:
    Q9UHA7
    Secondary Accessions:
    • B2RAD9
    • Q53SR7
    • Q5BLR4
    • Q7RTZ8

    Protein attributes for IL36A Gene

    Size:
    158 amino acids
    Molecular mass:
    17684 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Initial experiments using non-processed full length protein found in vitro activity only in the ug range.

neXtProt entry for IL36A Gene

Proteomics data for IL36A Gene at MOPED

Post-translational modifications for IL36A Gene

  • N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL36A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL36A (IL-36 alpha/IL-1F6)

No data available for DME Specific Peptides for IL36A Gene

Domains & Families for IL36A Gene

Gene Families for IL36A Gene

Protein Domains for IL36A Gene

Suggested Antigen Peptide Sequences for IL36A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHA7

UniProtKB/Swiss-Prot:

IL36A_HUMAN :
  • Belongs to the IL-1 family.
Family:
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL36A: view

Function for IL36A Gene

Molecular function for IL36A Gene

UniProtKB/Swiss-Prot Function:
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T cell proliferation. May play a role in proinflammatory effects in the lung.
UniProtKB/Swiss-Prot Induction:
By Il-1 and TNF-alpha.
genes like me logo Genes that share phenotypes with IL36A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IL36A

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IL36A Gene

Localization for IL36A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL36A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL36A Gene COMPARTMENTS Subcellular localization image for IL36A gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for IL36A Gene

Pathways & Interactions for IL36A Gene

genes like me logo Genes that share pathways with IL36A: view

Pathways by source for IL36A Gene

1 R&D Systems pathway for IL36A Gene

Interacting Proteins for IL36A Gene

Gene Ontology (GO) - Biological Process for IL36A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 10625660
GO:0019221 cytokine-mediated signaling pathway IBA --
genes like me logo Genes that share ontologies with IL36A: view

No data available for SIGNOR curated interactions for IL36A Gene

Drugs & Compounds for IL36A Gene

No Compound Related Data Available

Transcripts for IL36A Gene

mRNA/cDNA for IL36A Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL36A Gene

Interleukin 36, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL36A Gene

No ASD Table

Relevant External Links for IL36A Gene

GeneLoc Exon Structure for
IL36A
ECgene alternative splicing isoforms for
IL36A

Expression for IL36A Gene

mRNA expression in normal human tissues for IL36A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL36A Gene

This gene is overexpressed in Esophagus - Mucosa (x44.3) and Minor Salivary Gland (x4.1).

Protein differential expression in normal tissues from HIPED for IL36A Gene

This gene is overexpressed in Cervix (47.1), Saliva (12.5), and Esophagus (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL36A Gene



SOURCE GeneReport for Unigene cluster for IL36A Gene Hs.278910

mRNA Expression by UniProt/SwissProt for IL36A Gene

Q9UHA7-IL36A_HUMAN
Tissue specificity: Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin.
genes like me logo Genes that share expression patterns with IL36A: view

Protein tissue co-expression partners for IL36A Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for IL36A Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL36A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL36A 35
  • 76.39 (n)
  • 70.83 (a)
IL36A 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il1f6 35
  • 68.8 (n)
  • 54.49 (a)
Il1f6 16
Il1f6 36
  • 53 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL1F6 35
  • 99.16 (n)
  • 99.37 (a)
IL36A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il36a 35
  • 68.38 (n)
  • 57.05 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
Species with no ortholog for IL36A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL36A Gene

ENSEMBL:
Gene Tree for IL36A (if available)
TreeFam:
Gene Tree for IL36A (if available)

Paralogs for IL36A Gene

Paralogs for IL36A Gene

(5) SIMAP similar genes for IL36A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL36A: view

Variants for IL36A Gene

Sequence variations from dbSNP and Humsavar for IL36A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs895497 - 113,005,998(-) TCCCC(C/G/T)GCTGA reference, missense
rs28938798 - 113,006,661(+) CCCCA(C/T)CTACC reference, missense
rs28947175 - 113,007,967(+) CTGAA(A/G)GAGGC reference, missense
rs725139 -- 113,009,977(+) GACTT(C/G)TTTTT intron-variant
rs725140 -- 113,010,010(+) TTCTT(C/T)TTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL36A Gene

Variant ID Type Subtype PubMed ID
nsv874878 CNV Gain 21882294
dgv4281n71 CNV Loss 21882294

Variation tolerance for IL36A Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL36A Gene

HapMap Linkage Disequilibrium report
IL36A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL36A Gene

Disorders for IL36A Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL36A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
psoriasis
- elite association - COSMIC cancer census association via MalaCards
Search IL36A in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL36A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL36A
genes like me logo Genes that share disorders with IL36A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL36A Gene

Publications for IL36A Gene

  1. Four new members expand the IL-1 superfamily. (PMID: 10625660) Smith D.E. … Sims J.E. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X. … Desiderio D.M. (Anal. Biochem. 2006) 3 23
  3. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. (PMID: 14734551) Towne J.E. … Sims J.E. (J. Biol. Chem. 2004) 3 23
  4. IL-36I+ induces maturation of Th1-inducing human MDDC and synergises with IFN-I^ to induce high surface expression of CD14 and CD11c. (PMID: 25700962) Higgins J. … Foster N. (Hum. Immunol. 2015) 3
  5. IL-36I+ axis is modulated in patients with primary Sjogren's Syndrome. (PMID: 25902739) Ciccia F. … Triolo G. (Clin. Exp. Immunol. 2015) 3

Products for IL36A Gene

Sources for IL36A Gene

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